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TFAP2B Gene

protein-coding GIFtS: 66

GC06P050894

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
(Previous name: transcription factor AP-2 beta (activating enhancer-binding protein 2 beta) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AP-2B ^²
AP2-B ^¹, ²
AP2-beta ^³
CHAR ^⁵
MGC21381 ^²
OTTHUMP00000039925 ^²

Descriptions
Activating enhancer-binding protein 2 beta ^³
activating enhancer binding protein 2 beta ^²
transcription factor AP-2 beta ^²
transcription factor AP-2 beta (activating enhancer binding protein 2 beta) ^²
transcription factor AP-2 beta (activating enhancer-binding protein 2 beta) ^¹

External Ids
HGNC: 11743¹
Entrez Gene: 7021²
UniProtKB: Q92481³
Ensembl: ENSG00000008196⁷

Search outside databases for aliases for TFAP2B gene

Previous GC identifers: GC06P050788 GC06P050833

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TFAP2B:

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or

hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to

stimulate cell proliferation and suppress terminal differentiation of specific cell types during

embryonic development. Specific AP-2 family members differ in their expression patterns and

binding affinity for different promoters. This protein functions as both a transcriptional

activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome,

suggesting that this gene functions in the differentiation of neural crest cell derivatives.

[provided by RefSeq]

UniProtKB/Swiss-Prot: AP2B_HUMAN, Q92481

Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular

enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus

sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological

functions including proper eye, face, body wall, limb and neural tube development. They also

suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 beta appears to be

required for normal face and limb development and for proper terminal differentiation and function

of renal tubular epithelia

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TFAP2B gene

Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12

TFAP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P050894: (about GC identifiers)

Start:	50,894,398 bp from pter
End:	50,923,285 bp from pter
Size:	28,888 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AP2B_HUMAN, Q92481 (See protein sequence)

Recommended Name: Transcription factor AP-2 beta

Size: 460 amino acids; 50474 Da

Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.

Interacts with CITED4. Interacts with UBE2I

Subcellular location: Nucleus (Probable)

Secondary accessions: Q5JYX6 Q9NQ63 Q9NU99 Q9UJI7 Q9Y214 Q9Y3K3

Alternative splicing: 2 isoforms: Q92481-1 Q92481-2

Post-translational modifications:

Sumoylated on Lys-21; which inhibits transcriptional activity (Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003212.2

ENSEMBL proteins:

ENSP00000377265 ENSP00000342252 ENSP00000263046

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AP2 alpha + beta, AP2 beta)
	Human Recombinant Proteins from Abnova (TFAP2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	12169688

About this table

Antibodies for TFAP2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TFAP2B
	R&D Systems Antibodies for TFAP2B (AP-2 beta)
	Cell Signaling Technology (CST) Antibodies for TFAP2B (AP-2-beta)
	Antibodies from Abcam (AP2 alpha + beta, AP2 beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TFAP2B)
	Novus Biologicals Antibodies for TFAP2B

Assays for TFAP2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92481

ProtoNet protein and cluster: Q92481

2 Blocks protein families:

IPB004979 Transcription factor AP-2 signature

IPB008122 Transcription factor AP-2 beta signature

UniProtKB/Swiss-Prot: AP2B_HUMAN, Q92481

Similarity: Belongs to the AP-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFAP2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFAP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003221

Applied Biosystems Silencer® siRNAs for TFAP2B

Sigma-Aldrich siRNA for TFAP2B

Sigma-Aldrich shRNA for TFAP2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TFAP2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003221
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003221
untagged cDNA clones in CMV expression vector (see all 4): NM_003221

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003221

UniProtKB/Swiss-Prot: AP2B_HUMAN, Q92481

Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular

enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus

sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological

functions including proper eye, face, body wall, limb and neural tube development. They also

suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 beta appears to be

required for normal face and limb development and for proper terminal differentiation and function

of renal tubular epithelia

Genatlas biochemistry entry for TFAP2B:

transcription factor 2,AP-2,beta regulating the expression of genes required for development of

ectodermal tissues

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tcfap2b):

behavior/neurological	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
limbs/digits/tail	muscle	renal/urinary system	skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	12169688
GO:0003713	transcription coactivator activity	TAS	7555706
GO:0043565	sequence-specific DNA binding	IDA	12169688
GO:0046983	protein dimerization activity	IDA	12072434

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TFAP2B

5/9 Interacting proteins for TFAP2B (Q92481^{1, 2} ENSP00000263046³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CITED2	Q99967¹, ENSP00000356623³	EBI-725275, EBI-937732 STRING (score=.954)
HIST1H2AC	Q93077²	MINT-65092
VPS11	Q9H270²	MINT-65489
CITED4	ENSP00000361721³	STRING (score=.822)
MCAM	ENSP00000264036³	STRING (score=.821)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	7555706
GO:0007399	nervous system development	TAS	7555706
GO:0045817	positive regulation of transcription from RNA polymerase II promoter, global	IDA	12169688

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TFAP2B
1 Novoseek chemical compound relationship for TFAP2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	0.00	5	16373417 (3), 19022887 (1), 16954217 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFAP2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFAP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003221

Sigma-Aldrich siRNA for TFAP2B

Sigma-Aldrich shRNA for TFAP2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003221

REFSEQ mRNAs for TFAP2B gene:

NM_003221.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003221

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003221
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003221
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_003221

Additional cDNA sequence:

AK291172.1 AK313749.1 BC037225.1 X95694.1

7 DOTS entries:

DT.113011 DT.113010 DT.92418765 DT.100686372 DT.100839448 DT.426709 DT.97823073

24/55 AceView cDNA sequences (see all 55 ):

NM_003221 BX112958 BM681122 AI275084 BM675692 AA019703 BC037225 X95694

AU108033 AU077117 AW300385 AU100276 BM687774 AI695268 AU116928 BP380475

BP380919 BE048362 BE075773 AA330860 BM699043 AI160950 AU141084 BM666316

highest scoring ESTs for TFAP2B:

X95694 AA018906 AI160950 AI275084 AI909045 AI951174 AU144832 AW772183 BC037225 BE048362

Unigene Cluster for TFAP2B:

Transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Hs.33102 [show with all ESTs]

Unigene Representative Sequence: NM_003221

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000393655 ENST00000344788 ENST00000263046

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TFAP2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TFAP2B

¹ / ² / ³

6 probe-sets matching TFAP2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39668_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X95694	1.00	1.00	1.00	1
214451_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003221	0.60	1.00	0.82	1
215686_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
214451_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553394_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215686_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAAGTTTGT

SOURCE GeneReport for Unigene cluster: Hs.33102
Expression variation in blood from EXPOLDB for TFAP2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TFAP2B gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TFAP2B¹	--	transcription factor AP-2 beta (activating enhancer more	96.07(n) 100(a)	403463 XM_850459.1 XP_855552.1
chimpanzee (Pan troglodytes)	TFAP2B¹	--	transcription factor AP-2 beta (activating enhancer more	99.93(n) 100(a)	462758 XM_001149948.1 XP_001149948.1
cow (Bos taurus)	TFAP2B¹	--	transcription factor AP-2 beta (activating enhancer more	95.36(n) 100(a)	540867 NM_001076247.1 NP_001069715.1
rat (Rattus norvegicus)	Tcfap2b¹	--	transcription factor AP-2 beta	91.83(n) 99.55(a)	301285 XM_217356.4 XP_217356.3
mouse (Mus musculus)	Tcfap2b^{1, 5}	1⁵	transcription factor AP-2 beta^{1, 5}	92.59(n)¹ 100(a)¹	21419¹ NM_009334.2¹ NP_033360.2¹ AI447759⁵ AI606113⁵ (see all 15)

About this table Species with no ortholog for TFAP2B

ENSEMBL Gene Tree for TFAP2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TFAP2B gene

TFAP2C² TFAP2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/263 NCBI SNPs in TFAP2B are shown (see all 263 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 153)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2817419^1,2	A,C,F,H	50920865(+)	`TAGACA/GAGATC`	1	--	ut3¹		12	EU EA WA NA	1026
	rs7743255^1,2	A,C,F,H	50893863(+)	`AGTTTC/TCAAAG`	1	--	ng5¹		4	EU EA WA	368
	rs7769978^1,2	A,C,F,H	50923188(+)	`TTTTCT/CGTTCT`	1	--	ut3¹		7	EU EA WA NA	520
	rs2206271^1,2	A,C,F,H	50893967(-)	`ACACAA/TCTTTT`	1	--	ng5¹		4	EA WA	1700
	rs2272903^1,2	C,F,H	50894530(-)	`CAGGAC/TTCCGC`	1	--	ut5¹ ese³		19	EA NS NA MN EU WA	2904
	rs9296643^1,2	C,F,H	50920854(+)	`ATTTAA/GCAAAG`	1	--	ut3¹		4	EU EA WA	394
	rs2817420^1,2	A,F,H	50921291(+)	`AGAGCC/TCGGCC`	1	--	ut3¹		4	EU EA WA	400
	rs2982621^1,2	A,C,F	50919200(+)	`AATTTA/TAAAAA`	1	--	ut3¹		3	NA	138
	rs10456638^1,2	A,F,H	50893132(+)	`CGCAGA/GGCTGC`	1	--	ng5¹		4	EU EA WA	388
--	rs2744475^1,2	C,F	50892839(-)	`TTTTCG/CTTCCT`	1	--	ng5¹		1	EA	744

About this table

HapMap Linkage Disequilibrium images for TFAP2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601601 disorders: 169100

UniProtKB/Swiss-Prot: AP2B_HUMAN, Q92481

Defects in TFAP2B are the cause of Char syndrome (CHAR) [MIM:169100]. CHAR is an autosomal

dominant disorder characterized by patent ductus arteriosus (PDA), facial dysmorphism and hand

anomalies

5 Novoseek disease relationships for TFAP2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
char syndrome	89.87	4	11505339 (3), 11137286 (1)
bipolar disorder	18.92	1	16787706 (1)
insulin resistance	15.72	2	19022887 (1), 16954217 (1)
cancer	0.00	3	17630431 (1)
tumors	0.00	6	19336370 (2), 17630431 (2)

About this table

GeneTests: TFAP2B

Char Syndrome

Human Gene Mutation Database: TFAP2B
Genetic Association Database: TFAP2B
Human Genome Epidemiology Navigator: TFAP2B (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/67 PubMed articles for TFAP2B gene (see all 67 ):

Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. (PubMed id 8661133)^{1, 2, 3, 4} Williamson J.A....Hurst H.C. (1996)
Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder. (PubMed id 15722186)^{1, 3, 6} Damberg M....Eriksson E. (2005)
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. (PubMed id 15940393)^{1, 3, 6} Maeda S....Nakamura Y. (2005)
Novel TFAP2B mutations that cause Char syndrome provide a genotype- phenotype correlation. (PubMed id 11505339)^{1, 3, 4} Zhao F.... Gelb B.D. (2001)
Transcription factor AP-2beta genotype associated with anxiety-related personality traits in women. A replication study. (PubMed id 14673213)^{1, 3, 6} Damberg M....Jonsson E.G. (2003)
Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. (PubMed id 9271117)^{1, 3, 4} Moser M. and Buettner R. (1997)
Transcription factor AP-2beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans. (PubMed id 15057523)^{3, 6} Damberg M....Jonsson E.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. (PubMed id 12072434)^{3, 4} Eloranta J.J. and Hurst H.C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7021	HGNC: 11743	AceView: TFAP2B	Ensembl:ENSG00000008196	euGenes: HUgn7021
ECgene: TFAP2B	H-InvDB: TFAP2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TFAP2B	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=TFAP2B
Wikipedia	http://en.wikipedia.org/wiki/Activating_protein_2

Licensable Technologies for TFAP2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TFAP2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TFAP2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TFAP2B		Antibodies for TFAP2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TFAP2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TFAP2B)
	Antibodies (TFAP2B)
	Chimera RNAi (TFAP2B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TFAP2B (AP-2-beta)

	Recombinant Proteins (AP2 alpha + beta, AP2 beta)
	Antibodies (AP2 alpha + beta, AP2 beta)

Search OriGene for TFAP2B

Search Tocris compounds for TFAP2B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TFAP2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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TFAP2B Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for TFAP2B

Summaries
for TFAP2B

Genomic Location
for TFAP2B

Proteins
for TFAP2B

Protein Domains/
Families
for TFAP2B

Gene Function
for TFAP2B

Pathways & Interactions
for TFAP2B

Drugs & Compounds
for TFAP2B

Transcripts
for TFAP2B

Expression
for TFAP2B

Orthologs
for TFAP2B

Paralogs
for TFAP2B

SNPs/Variants
for TFAP2B

Disorders & Mutations
for TFAP2B

Medical News
for TFAP2B

Publications
for TFAP2B

Search for TFAP2B

Genome Databases showing TFAP2B

Other Databases showing TFAP2B

Specialized Databases showing TFAP2B

Licensable Technologies
for TFAP2B

Services
for TFAP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TFAP2B Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor TFAP2B

Summariesfor TFAP2B

Genomic Locationfor TFAP2B

Proteinsfor TFAP2B

Protein Domains/Familiesfor TFAP2B

Gene Functionfor TFAP2B

Pathways & Interactionsfor TFAP2B

Drugs & Compoundsfor TFAP2B

Transcriptsfor TFAP2B

Expression for TFAP2B

Orthologsfor TFAP2B

Paralogsfor TFAP2B

SNPs/Variantsfor TFAP2B

Disorders & Mutationsfor TFAP2B

Medical Newsfor TFAP2B

Publicationsfor TFAP2B

Search for TFAP2B

Genome Databases showing TFAP2B

Other Databases showing TFAP2B

Specialized Databases showing TFAP2B

Licensable Technologiesfor TFAP2B

Servicesfor TFAP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TFAP2B

Summaries
for TFAP2B

Genomic Location
for TFAP2B

Proteins
for TFAP2B

Protein Domains/
Families
for TFAP2B

Gene Function
for TFAP2B

Pathways & Interactions
for TFAP2B

Drugs & Compounds
for TFAP2B

Transcripts
for TFAP2B

Expression
for TFAP2B

Orthologs
for TFAP2B

Paralogs
for TFAP2B

SNPs/Variants
for TFAP2B

Disorders & Mutations
for TFAP2B

Medical News
for TFAP2B

Publications
for TFAP2B

Licensable Technologies
for TFAP2B

Services
for TFAP2B