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TFAP2A Gene

protein-coding GIFtS: 63

GC06M010503

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
(Previous name: transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TFAP2, AP2TF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AP-2 ^¹, ², ³
AP-2alpha ^²
AP2-alpha ^³
AP2TF ^², ³, ⁵
BOFS ^², ⁵
FLJ51761 ^²
OTTHUMP00000016013 ^²
OTTHUMP00000016014 ^²
TFAP2 ^², ³

Descriptions
AP-2 transcription factor ^³
Activating enhancer-binding protein 2 alpha ^², ³
Activator protein 2 ^³
transcription factor AP-2 alpha ^²
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) ^²
transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha) ^¹, ²

External Ids
HGNC: 11742¹
Entrez Gene: 7020²
UniProtKB: P05549³
Ensembl: ENSG00000137203⁷

Search outside databases for aliases for TFAP2A gene

Previous GC identifers: GC06M010455 GC06M010506

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TFAP2A:

AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of

transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and

metallothionein (MIM 156350) promoters.[supplied by OMIM]

UniProtKB/Swiss-Prot: AP2A_HUMAN, P05549

Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular

enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus

sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological

functions including proper eye, face, body wall, limb and neural tube development. They also

suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2

protein required for early morphogenesis of the lens vesicle (By similarity)

Gene Wiki entry for TFAP2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TFAP2A gene

Entrez Gene cytogenetic band: 6p24 Ensembl cytogenetic band: 6p24.3 HGNC cytogenetic band: 6pter-p22.3

TFAP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M010503: (about GC identifiers)

Start:	10,504,902 bp from pter
End:	10,527,783 bp from pter
Size:	22,882 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AP2A_HUMAN, P05549 (See protein sequence)

Recommended Name: Transcription factor AP-2 alpha

Size: 437 amino acids; 48062 Da

Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.

Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a

complex also containing EPN1 and NUMB during interphase and mitosis

Subcellular location: Nucleus

Secondary accessions: Q13777

Alternative splicing: 4 isoforms: P05549-1 P05549-3 P05549-4 P05549-2 (Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

Sumoylated on Lys-10; which inhibits transcriptional activity (Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001027451.1 NP_001035890.1 NP_003211.1

ENSEMBL proteins:

ENSP00000368928 ENSP00000368924 ENSP00000368922 ENSP00000368933 ENSP00000316516

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AP2 alpha + beta, AP2 alpha)
	Human Recombinant Proteins from Abnova (TFAP2A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IMP	12586840

About this table

Antibodies for TFAP2A:

	Invitrogen Antibodies for TFAP2A
	Millipore Mono- and Polyclonal Antibodies for the study of TFAP2A
	Sigma-Aldrich Antibody Arrays and Antibodies for TFAP2A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TFAP2A (AP-2-alpha)
	Antibodies from Abcam (AP2 alpha + beta, AP2 alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TFAP2A)
	Novus Biologicals Antibodies for TFAP2A

Assays for TFAP2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05549

ProtoNet protein and cluster: P05549

2 Blocks protein families:

IPB004979 Transcription factor AP-2 signature

IPB008121 Transcription factor AP-2 alpha signature

UniProtKB/Swiss-Prot: AP2A_HUMAN, P05549

Domain: The WW-binding motif mediates interaction with WWOX (By similarity)

Similarity: Belongs to the AP-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFAP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFAP2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003220

Applied Biosystems Silencer® siRNAs for TFAP2A

Sigma-Aldrich siRNA for TFAP2A

Sigma-Aldrich shRNA for TFAP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TFAP2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032280
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032280
untagged cDNA clones in CMV expression vector (see all 4): NM_001032280

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003220

UniProtKB/Swiss-Prot: AP2A_HUMAN, P05549

Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular

enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus

sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological

functions including proper eye, face, body wall, limb and neural tube development. They also

suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2

protein required for early morphogenesis of the lens vesicle (By similarity)

Genatlas biochemistry entry for TFAP2A:

transcription factor 2,AP-2 alpha,retinoic acid responsive gene,52 kDa,regulating the expression of

genes required for development of tissues of ectodermal origin,activating CDKN1A (WAF1) and other

genes such as MCAM,MMP2,involved in the progression of human melanoma and potentially involved in

anterior eye chamber development

15/19 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Tcfap2a) (see all 19 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	lethality-postnatal
lethality-prenatal/perinatal	limbs/digits/tail	nervous system	normal	pigmentation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	1916817
GO:0003713	transcription coactivator activity	TAS	8321221
GO:0046983	protein dimerization activity	IDA	12072434

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TFAP2A

5/91 Interacting proteins for TFAP2A (P05549^{1, 2} ENSP00000368933³) via UniProtKB, MINT, and/or STRING (see all 91 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CITED2	Q99967¹, ENSP00000356623³	EBI-347351, EBI-937732 STRING (score=.995)
EP300	Q09472¹, ENSP00000263253³	EBI-347351, EBI-447295 STRING (score=.853)
NPM1	P06748²	MINT-4544864 MINT-4544816 MINT-4544848 MINT-4544800 MINT-4544829 MINT-4544883
NPM1P21	P06748²	MINT-4544864 MINT-4544816 MINT-4544848 MINT-4544800 MINT-4544829 MINT-4544883
AP2A1	ENSP00000351926³	STRING (score=.991)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	8321221
GO:0007398	ectoderm development	TAS	8661133

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TFAP2A
10/54 Novoseek chemical compound relationships for TFAP2A gene (see all 54 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ryudocan	60.17	1	8797100 (1)
manganese superoxide	49.78	1	11853549 (1)
glycerol 3-phosphate	48.73	8	2249632 (1), 1753215 (1), 11884404 (1), 1665451 (1) (see all 7)
gw9662	44.25	3	17396233 (1), 16696951 (1)
fatty acid	41.00	48	1753215 (3), 17396233 (2), 17481768 (2), 15684432 (2) (see all 32)
tyrosine	37.55	29	9497313 (3), 8918456 (3), 16581796 (2), 11146001 (2) (see all 22)
mannose 6-phosphate	36.37	3	16914521 (1), 18817526 (1)
phosphatidylinositol phosphate	33.72	1	12913109 (1)
cyclic amp	31.42	12	9447955 (1), 10520459 (1), 10211885 (1), 18824087 (1) (see all 9)
lipid	30.86	33	9361822 (2), 10842659 (2), 11322759 (2), 16936206 (1) (see all 27)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFAP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFAP2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003220

Sigma-Aldrich siRNA for TFAP2A

Sigma-Aldrich shRNA for TFAP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001032280 NM_001042425 NM_003220

REFSEQ mRNAs for TFAP2A gene (3 alternative transcripts):

NM_001032280.2 NM_001042425.1 NM_003220.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001032280 NM_001042425 NM_003220

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032280
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032280
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001032280

Additional cDNA sequence:

AK296737.1 BC017754.1 BC071713.1 CR601719.1 CR604637.1 FJ794945.1 M61156.1

17 DOTS entries:

DT.86842214 DT.100783422 DT.91757999 DT.102842574 DT.91673313 DT.100783424 DT.95214380 DT.95155656

DT.100718848 DT.121332473 DT.97772917 DT.100682139 DT.100684667 DT.100783418 DT.121332363 DT.99967302

DT.100783417

24/197 AceView cDNA sequences (see all 197 ):

BQ673192 AI570166 CB853129 BG251670 CA945028 BM669517 BE855399 BM714268

AI223848 CD671135 AI362076 BF432486 BU631526 BU956975 AW026563 BU733969

BQ220260 CR601719 R81259 BM761995 BU527990 BM692663 BM722267 BU190540

highest scoring ESTs for TFAP2A:

AL546403 BG252096 BM724073 CF593975 M36711 M61156 X52611 AA075806 AA079248 AA454871

Unigene Cluster for TFAP2A:

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Hs.519880 [show with all ESTs]

Unigene Representative Sequence: NM_001032280

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:

ENST00000379608 ENST00000379604 ENST00000379602 ENST00000379613 ENST00000319516

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TFAP2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TFAP2A

¹ / ² / ³

10 probe-sets matching TFAP2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
792_s_at²^{, 3}	U95-A	1	1.00	1.00	0.26	1.02	X52611	0.80	1.00	0.91	1
32154_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.89	M36711	0.80	1.00	0.91	1
32155_at²^{, 3}	U95-A	2	1.00	0.97	0.45	0.53	M61156	0.80	1.00	0.91	1
1177_at²^{, 3}	U95-A	1	0.31	1.00	0.69	1.25	HG2465-HT4871	0.20	1.00	0.72	1
210669_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M61156	0.80	1.00	0.91	1
204653_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF343007	0.60	1.00	0.82	1
204654_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003220	0.60	1.00	0.82	1
210669_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204653_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204654_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TFAP2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGTCAATG

SOURCE GeneReport for Unigene cluster: Hs.519880
Expression variation in blood from EXPOLDB for TFAP2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TFAP2A gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TFAP2A¹	--	transcription factor AP-2 alpha (activating enhancer more	96.49(n) 99.08(a)	488213 XM_843875.1 XP_848968.1
chimpanzee (Pan troglodytes)	TFAP2A¹	--	transcription factor AP-2 alpha (activating enhancer more	99.92(n) 100(a)	462426 XM_001166719.1 XP_001166719.1
cow (Bos taurus)	TFAP2A¹	--	transcription factor AP-2 alpha (activating enhancer more	96.41(n) 98.63(a)	505849 XM_875452.2 XP_880545.1
rat (Rattus norvegicus)	Tcfap2a¹	--	transcription factor AP-2, alpha	94.23(n) 98.82(a)	306862 XM_225238.4 XP_225238.4
mouse (Mus musculus)	Tcfap2a^{1, 5}	13 (25.00 cM)⁵	transcription factor AP-2, alpha^{1, 5}	94.58(n)¹ 98.63(a)¹	21418¹ NM_011547.2¹ NP_035677.2¹ AB221578⁵ AI195964⁵ (see all 25)

About this table Species with no ortholog for TFAP2A

ENSEMBL Gene Tree for TFAP2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TFAP2A gene

TFAP2C² TFAP2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/158 NCBI SNPs in TFAP2A are shown (see all 158 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1675414^1,2	A,C,F,H	10520174(-)	`AGAAAA/GGAGGG`	3	--	int¹ ut5¹ ese³ trp³		9	MN EU EA WA NA	966
	rs1621700^1,2	A,C,F,H	10528084(-)	`GGCTAG/ACCATG`	1	--	ng3¹		8	EA NA EU WA	564
	rs303056^1,2	A,C,F,H	10528467(+)	`ACTCAG/CACTTA`	1	--	ng3¹		8	MN EA EU WA	1118
	rs1461012^1,2	A,C,F	10524004(-)	`AGGGGG/TTGGCT`	2	--	int¹ ng3¹		4	EA NA MN	246
	rs10456013^1,2	F,H	10506548(+)	`gGAAGG/TGTTGC`	3	--	ut3¹		4	EU EA WA	418
--	rs2763171^1,2	F,H	10505781(+)	`TCCCCC/AAAACA`	3	--	ut3¹		4	EU EA WA	420
	rs303054^1,2	A,F	10524624(-)	`CAAAAC/ACGAAA`	2	--	ng3¹ int¹		1	MN	184
	rs16893358^1,2	F,H	10505012(+)	`ATACAT/CTGGGT`	3	--	ut3¹		7	NA EU EA WA	560
	rs2763172^1,2	H	10506299(+)	`gttttG/Ttttaa`	3	--	ut3¹		4	EU EA WA	404
	rs2763168^1,2	H	10505113(+)	`TACTTG/TAGGGA`	3	--	ut3¹ ese³		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for TFAP2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 107580 disorders: 113620

UniProtKB/Swiss-Prot: AP2A_HUMAN, P05549

Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also

known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal

duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a

rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major

features include cutaneous anomalies, ocular anomalies, characteristic facial appearance

(malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair)

anomalies

10/64 Novoseek disease relationships for TFAP2A gene (see all 64 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma	49.82	6	11014230 (1), 11298758 (1), 11798181 (1), 9231796 (1) (see all 5)
teratocarcinoma	41.59	6	8321221 (1), 9858613 (1), 9889285 (1), 7926729 (1)
melanoma	38.11	110	14517845 (5), 12789289 (5), 9817279 (5), 11596105 (4) (see all 30)
metastatic melanoma	35.59	7	12789289 (2), 9810513 (1), 12741683 (1), 11310795 (1) (see all 6)
tumors	33.55	75	9817279 (6), 12226108 (5), 18218085 (5), 14996719 (3) (see all 40)
carcinoma non-small cell lung	32.64	1	15864740 (1)
breast cancer	32.00	63	15196531 (5), 9850080 (5), 15467710 (5), 12429639 (5) (see all 23)
insulin sensitivity	24.55	5	10842659 (1), 18324929 (1), 15686734 (1), 11891416 (1)
lung carcinoma	23.43	3	17237224 (1), 1953710 (1), 14551210 (1)
dysplastic nevi	16.00	2	11596105 (1), 16946713 (1)

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Human Gene Mutation Database: TFAP2A

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/616 PubMed articles for TFAP2A gene (see all 616 ):

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. (PubMed id 3063603)^{2, 3, 4} Williams T....Tjian R. (1988)
An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. (PubMed id 8321221)^{1, 3, 4} Buettner R.... Tainsky M.A. (1993)
The genomic structure of the human AP-2 transcription factor. (PubMed id 8190633)^{1, 3, 4} Bauer R.... Buettner R. (1994)
Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. (PubMed id 2010091)^{1, 3, 4} Williams T. and Tjian R. (1991)
TFAP2A mutations result in branchio-oculo-facial syndrome. (PubMed id 18423521)^{3, 4} Milunsky J.M....Lin A.E. (2008)
Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. (PubMed id 15548692)^{3, 4} Aqeilan R.I....Croce C.M. (2004)
Human CREB-binding protein/p300-interacting transactivator with ED- rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PubMed id 11744733)^{3, 4} Braganca J.... Bhattacharya S. (2002)
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. (PubMed id 12072434)^{3, 4} Eloranta J.J. and Hurst H.C. (2002)
Transcription factor AP-2 activity is modulated by protein kinase A- mediated phosphorylation. (PubMed id 10037142)^{3, 4} Garcia M.A.... Vazquez J. (1999)
Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. (PubMed id 1998122)^{3, 4} Williams T. and Tjian R. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7020	HGNC: 11742	AceView: TFAP2A	Ensembl:ENSG00000137203	euGenes: HUgn7020
ECgene: TFAP2A	H-InvDB: TFAP2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TFAP2A	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Activating_protein_2

Licensable Technologies for TFAP2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TFAP2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TFAP2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TFAP2A		Antibodies for TFAP2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TFAP2A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TFAP2A)
	Antibodies (TFAP2A)
	Chimera RNAi (TFAP2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TFAP2A (AP-2-alpha)

	Recombinant Proteins (AP2 alpha + beta, AP2 alpha)
	Antibodies (AP2 alpha + beta, AP2 alpha)

Search OriGene for TFAP2A

Search Tocris compounds for TFAP2A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TFAP2A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TFAP2A Gene at Home site.
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TFAP2A Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for TFAP2A

Summaries
for TFAP2A

Genomic Location
for TFAP2A

Proteins
for TFAP2A

Protein Domains/
Families
for TFAP2A

Gene Function
for TFAP2A

Pathways & Interactions
for TFAP2A

Drugs & Compounds
for TFAP2A

Transcripts
for TFAP2A

Expression
for TFAP2A

Orthologs
for TFAP2A

Paralogs
for TFAP2A

SNPs/Variants
for TFAP2A

Disorders & Mutations
for TFAP2A

Medical News
for TFAP2A

Publications
for TFAP2A

Search for TFAP2A

Genome Databases showing TFAP2A

Other Databases showing TFAP2A

Specialized Databases showing TFAP2A

Licensable Technologies
for TFAP2A

Services
for TFAP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TFAP2A Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor TFAP2A

Summariesfor TFAP2A

Genomic Locationfor TFAP2A

Proteinsfor TFAP2A

Protein Domains/Familiesfor TFAP2A

Gene Functionfor TFAP2A

Pathways & Interactionsfor TFAP2A

Drugs & Compoundsfor TFAP2A

Transcriptsfor TFAP2A

Expression for TFAP2A

Orthologsfor TFAP2A

Paralogsfor TFAP2A

SNPs/Variantsfor TFAP2A

Disorders & Mutationsfor TFAP2A

Medical Newsfor TFAP2A

Publicationsfor TFAP2A

Search for TFAP2A

Genome Databases showing TFAP2A

Other Databases showing TFAP2A

Specialized Databases showing TFAP2A

Licensable Technologiesfor TFAP2A

Servicesfor TFAP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TFAP2A

Summaries
for TFAP2A

Genomic Location
for TFAP2A

Proteins
for TFAP2A

Protein Domains/
Families
for TFAP2A

Gene Function
for TFAP2A

Pathways & Interactions
for TFAP2A

Drugs & Compounds
for TFAP2A

Transcripts
for TFAP2A

Expression
for TFAP2A

Orthologs
for TFAP2A

Paralogs
for TFAP2A

SNPs/Variants
for TFAP2A

Disorders & Mutations
for TFAP2A

Medical News
for TFAP2A

Publications
for TFAP2A

Licensable Technologies
for TFAP2A

Services
for TFAP2A