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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TF Gene

protein-coding   GIFtS: 72
GCID: GC03P133464

Transferrin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
transferrin1 2     TFQTL12
Transferrin3     serotransferrin2
Beta-1 Metal-Binding Globulin2 3     siderophilin2
PRO15572     Siderophilin3
PRO20862     EC 3.4.218

External Ids:    HGNC: 117401   Entrez Gene: 70182   Ensembl: ENSG000000915137   OMIM: 1900005   UniProtKB: P027873   

Export aliases for TF gene to outside databases

Previous GC identifers: GC03P130424 GC03P134209 GC03P134746 GC03P134786 GC03P134727 GC03P134947 GC03P133419 GC03P130844


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TF Gene:
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been
created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal
domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the
intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This
protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of
certain organic matter and allergens from serum. (provided by RefSeq, Sep 2009)

GeneCards Summary for TF Gene: 
TF (transferrin) is a protein-coding gene. Diseases associated with TF include atransferrinemia, and siderosis, and among its related super-pathways are Response to elevated platelet cytosolic Ca2+ and Insulin receptor recycling. GO annotations related to this gene include ferric iron binding and ubiquitin protein ligase binding. An important paralog of this gene is MFI2.

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787
Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the
binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption
and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in
stimulating cell proliferation

Gene Wiki entry for TF (Transferrin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TF gene promoter:
         HOXA9   HOXA9B   NRSF form 1   FOXD3   NRSF form 2   HNF-3beta   Meis-1b   AREB6   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): TF promoter sequence
   Search SABiosciences Chromatin IP Primers for TF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q21

TF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TF gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P133464:  view genomic region     (about GC identifiers)

Start:
133,464,800 bp from pter      End:
133,497,850 bp from pter
Size:
33,051 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787 (See protein sequence)
Recommended Name: Serotransferrin precursor  
Size: 698 amino acids; 77064 Da
Subunit: Monomer
Subcellular location: Secreted
Sequence caution: Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/33 PDB 3D structures from and Proteopedia for TF (see all 33):
1A8E (3D)        1A8F (3D)        1B3E (3D)        1BP5 (3D)        1BTJ (3D)        1D3K (3D)    
Secondary accessions: O43890 Q1HBA5 Q9NQB8 Q9UHV0

Explore the universe of human proteins at neXtProt for TF: NX_P02787

Explore proteomics data for TF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02787

  • 4 DME Specific Peptides for TF (P02787)
     GDVAFVK  GKKSCHT  YSGAFKCL  KADRDQYELLC 

    TF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TF Protein Expression
    REFSEQ proteins: NP_001054.1  
    ENSEMBL proteins: 
     ENSP00000385834   ENSP00000417468   ENSP00000401505   ENSP00000418396   ENSP00000419338  
     ENSP00000418716   ENSP00000419714   ENSP00000264998  
    Reactome Protein details: P02787
    Human Recombinant Protein Products for TF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TF (Holo-Transferrin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TF
    OriGene Protein Over-expression Lysate for TF
    OriGene MassSpec for TF 
    OriGene Custom Protein Services for TF
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    Novus Biologicals TF Proteins
    Novus Biologicals TF Lysates
    Sino Biological Recombinant Protein for TF
    Sino Biological Cell Lysate for TF 
    ProSpec Recombinant Protein for TF
    Cloud-Clone Corp. Proteins for TF 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005739mitochondrion IDA--
    GO:0005769early endosome IDA15880641
    GO:0005770late endosome IDA15880641
    GO:0005905coated pit IDA12857860

    TF for ontologies           About GeneDecksing



    TF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TF
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    Cloud-Clone Corp. Antibodies for TF 
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    LSBio Antibodies in human, mouse, rat for TF 

    Assay Products for TF: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TF 
    Cloud-Clone Corp. CLIAs for TF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001156 Transferrin_fam
     IPR018195 Transferrin_Fe_BS
     IPR016357 Transferrin

    Graphical View of Domain Structure for InterPro Entry P02787

    ProtoNet protein and cluster: P02787

    1 Blocks protein domain: IPB001156 Transferrin

    UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787
    Similarity: Belongs to the transferrin family
    Similarity: Contains 2 transferrin-like domains


    TF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRFE_HUMAN, P02787
    Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the
    binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption
    and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in
    stimulating cell proliferation

         Genatlas biochemistry entry for TF:
    transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3

         Enzyme Number (IUBMB): EC 3.4.212

         Summary:
    TF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Renal proximal tubularlike cells from Kidney, Embryoid bodies from Endothelium (see all).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15880641
    GO:0008199ferric iron binding IEA--
    GO:0031625ubiquitin protein ligase binding IEA--
         
    TF for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TF:
     Increased G1 DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trf):
     growth/size  hematopoietic system  homeostasis/metabolism  mortality/aging 

    TF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TF
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TF:
    hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidTF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TF
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    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TF
    Sirion Biotech Customized adenovirus for overexpression of TF

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TF (see all 7)
    OriGene ORF clones in mouse, rat for TF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TF (NM_005171)
    Sino Biological Human cDNA Clone for TF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TF
    Sirion Biotech Customized lentivirus for stable overexpression of TF 
                         Customized lentivirus expression plasmids for stable overexpression of TF 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TF
    Search LifeMap BioReagents cell lines for TF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TF About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    2Insulin receptor recycling
    Transferrin endocytosis and recycling0.79
    Iron uptake and transport0.69
    3Platelet activation, signaling and aggregation
    Platelet activation, signaling and aggregation0.43
    Hemostasis0.43
    4SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    5Cell adhesion Ephrins signaling
    EPHB forward signaling0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TF
        Selected targets of ESR1
    Selected targets of C/EBPalpha


    4 BioSystems Pathways for TF
        SIDS Susceptibility Pathways
    Iron metabolism in placenta
    HIF-1-alpha transcription factor network
    EPHB forward signaling


    5/7        Reactome Pathways for TF (see all 7)
        Hemostasis
    Transmembrane transport of small molecules
    Platelet degranulation
    Iron uptake and transport
    Platelet activation, signaling and aggregation


    2         Kegg Pathways  (Kegg details for TF):
        HIF-1 signaling pathway
    Mineral absorption


    TF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for TF (P027872, 3 ENSP000002649984) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HFEQ302012, 3, ENSP000004174044MINT-7896348 MINT-7896317 MINT-7896366 MINT-7896258 MINT-7896330 I2D: score=2 STRING: ENSP00000417404
    GASTP013502, 3, ENSP000003313584MINT-7212849 MINT-7212881 MINT-7212832 MINT-7212864 MINT-7212909 I2D: score=1 STRING: ENSP00000331358
    CALRP277973, ENSP000003208664I2D: score=3 STRING: ENSP00000320866
    TFR2Q9UP523, ENSP000002230514I2D: score=3 STRING: ENSP00000223051
    ENSG00000258947Q135093I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006826iron ion transport ----
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--

    TF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TF (TRFE)

    4 HMDB Compounds for TF    About this table
    CompoundSynonyms CAS #PubMed Ids
    BismuthBi (see all 2)7440-69-9--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    IronArmco iron (see all 19)7439-89-6--

    4 DrugBank Compounds for TF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bismuth SubsalicylateBismuth (see all 6)14882-18-9carrier--11110794 15519234 15544343 12620681 17330963
    Iron DextranDexferrum (see all 2)9004-66-4carriersubstrate272031 10084288 11576368 2208657 17316146
    Aluminium-- 7429-90-5target--11327511 17629565 16301797 16139893
    Gallium nitrate-- 13494-90-1carriersubstrate19621374 18475921 16373528

    10/127 Novoseek inferred chemical compound relationships for TF gene (see all 127)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 95.5 6347 15292463 (9), 10556206 (8), 10945243 (8), 8623803 (8) (see all 99)
    apotransferrin 89.4 58 16925790 (2), 7508710 (2), 8151309 (2), 1769555 (1) (see all 44)
    iron sucrose 88.5 51 11071973 (5), 8918625 (3), 19010259 (2), 14767009 (2) (see all 29)
    iron dextran 79.5 16 9398141 (2), 9415935 (2), 7611266 (1), 1522796 (1) (see all 13)
    ferric gluconate 76.1 9 17267740 (1), 19260610 (1), 19034302 (1), 8671901 (1) (see all 7)
    fe3+ 74.1 78 15231685 (8), 19820086 (3), 10945247 (2), 11128996 (2) (see all 49)
    deferoxamine 70.7 69 8306330 (6), 1649718 (2), 1629195 (2), 8280612 (2) (see all 37)
    ferric ammonium citrate 70.4 29 11335103 (4), 1629195 (2), 7488642 (2), 9657901 (2) (see all 11)
    protoporphyrin ix 68.9 62 1519605 (4), 7832579 (2), 1619469 (2), 2044721 (1) (see all 56)
    kp-1019 68.9 6 16440400 (3), 18512673 (1), 18433763 (1), 16603249 (1)

    Search CenterWatch for drugs/clinical trials and news about TF / TRFE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TF gene: 
    NM_001063.3  

    Unigene Cluster for TF:

    Transferrin
    Hs.518267  [show with all ESTs]
    Unigene Representative Sequence: CR936810
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402696(uc003epu.2 uc011bls.1 uc003epv.2 uc011blt.2 uc003epw.2)
    ENST00000466911 ENST00000474287 ENST00000460531 ENST00000414694 ENST00000494430
    ENST00000493011 ENST00000482271 ENST00000485977 ENST00000475382 ENST00000498622
    ENST00000461695 ENST00000462495 ENST00000467842 ENST00000264998
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TF:
    hsa-miR-186
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TF

    Additional mRNA sequence: 

    AF118093.1 AJ252279.1 AK222755.1 AK293842.1 AK295334.1 AK295419.1 AK303753.1 AK312094.1 
    BC020671.1 BC045772.1 BC059367.1 BX648533.1 CR936810.1 DQ923758.1 M12525.1 M12530.1 
    M26641.1 S95936.1 U88581.1 

    24/47 DOTS entries (see all 47):

    DT.101987325  DT.100888172  DT.100888145  DT.100888157  DT.100888151  DT.40265225  DT.97864666  DT.40115686 
    DT.99970516  DT.97864665  DT.100888152  DT.98131781  DT.40125951  DT.91968032  DT.120892237  DT.120892195 
    DT.120892183  DT.100888164  DT.120892071  DT.100888165  DT.120892212  DT.100888169  DT.91914782  DT.92457961 

    24/826 AceView cDNA sequences (see all 826):

    BM712527 BM664706 BM702617 AW963231 BM668217 AU104079 BM704252 AA345207 
    BQ007066 BM666816 T75011 BU736739 BX346153 BM683652 BM693491 BP360995 
    BU726135 BQ185711 BM664782 BM695146 BG563771 BQ636653 CB164220 BM665143 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TF (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^
    SP1:                          -                       -     -                                                                             -     -               
    SP2:                          -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         
    SP3:        -     -     -     -                       -     -                                                                                                   
    SP4:                          -                                                                                                                                 
    SP5:                                                  -     -                                                                                                   

    ExUns: 17 ^ 18a · 18b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TF expression in normal human tissues (normalized intensities)      TF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTGAAC
    TF Expression
    About this image


    TF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 30 entries
             Thalamus
             Brain Pericytes   
             Globus Pallidus   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             Adipocyte   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Endoderm Cells Extraembryonic Endoderm
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...

    See TF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TF

    SOURCE GeneReport for Unigene cluster: Hs.518267

    UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787
    Tissue specificity: Expressed by the liver and secreted in plasma

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TF gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trf1 , 5 transferrin1, 5 78.15(n)1
    74.1(a)1
      9 (55.03 cM)5
    220411  NM_133977.21  NP_598738.11 
     1032040015 
    chicken
    (Gallus gallus)
    Aves LTF1 lactotransferrin 60.26(n)
    53.67(a)
      396241  NM_205304.1  NP_990635.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    50(a)
    1 → many
    3(30949265-30974075)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.285382 Transcribed sequence 79.31(n)    CF722973.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsf26
    Tsf16
    (see all 3)
    Transferrin 1
    (see all 3)
    26(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3L(12523536-12526824)
    X(18281965-18284377)


    ENSEMBL Gene Tree for TF (if available)
    TreeFam Gene Tree for TF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TF gene
    MFI22  LTF2  
    2 SIMAP similar genes for TF using alignment to 11 protein entries:     TRFE_HUMAN (see all proteins):
    LTF    MFI2

    TF for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TF
    PGOHUM00000259871 PGOHUM00000259872 PGOHUM00000259873


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787
    Polymorphism: Different polymorphic variants of transferrin are known. The sequence shown is the predominant
    electrophoretic variant (C1 or TF*C1)


    10/916 SNPs in TF are shown (see all 916)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0388104
    Atransferrinemia (ATRAF)4--see VAR_0388102 D N mis40--------
    VAR_0129974
    Atransferrinemia (ATRAF)4--see VAR_0129972 A P mis40--------
    rs412957741,2,4
    C,Fpathogenic1133457243(+) TGCCCA/GCGGGT 2 H R mis17Minor allele frequency- G:0.00NS NA EU 6199
    rs1219186801,2
    Cpathogenic1133458695(+) CCACCA/GAAGAC 2 K E mis10--------
    rs10492961,2,4
    C,F,Hpathogenic1133474899(+) GGAAAC/TCTGTG 2 P S mis1 ese354Minor allele frequency- T:0.14NS MN EA NA WA CSA EU 11880
    rs1219186771,2,4
    C,Fpathogenic1133476579(+) CTTAGG/AAGAAG 2 /E /G mis12Minor allele frequency- A:0.00NA EU 5869
    rs17998991,2,4
    C,F,Hunknown1133456357(+) TGGGCG/AGCAAG 2 /S /G mis124Minor allele frequency- A:0.03NS MN EA NA EU 8181
    VAR_0581994
    ----see VAR_0581992 I V mis40--------
    VAR_0129984
    ----see VAR_0129982 K E mis40--------
    rs711364931,2
    C--130850623(-) CTCTC-/A/AA  
            
    AAAAA
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for TF (133464800 - 133497850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877507CNV Loss21882294
    nsv4018CNV Loss18451855
    nsv829729CNV Loss17160897
    nsv877508CNV Loss21882294
    nsv877506CNV Gain21882294


    Human Gene Mutation Database (HGMD): TF
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190000   
    OMIM disorders: 209300  
    UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787
  • Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal
    synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 20/243 diseases for TF (see all 243):    About MalaCards
    atransferrinemia    siderosis    alcohol abuse    superficial siderosis
    superficial siderosis of the central nervous system    lipoid nephrosis    marasmus    hyperferritinemia cataract syndrome
    hemosiderosis    microcytic anemia    yellow nail syndrome    iron deficiency anemia
    congenital disorder of glycosylation type i    iron metabolism disease    restless legs syndrome    dysentery
    hypochromic microcytic anemia    hemochromatosis    trypanosomiasis    congenital disorder of glycosylation type ii

    20 diseases from the University of Copenhagen DISEASES database for TF:
    Hemochromatosis     Anemia     Substance abuse     Congenital disorder of glycosylation
    Liver disease     Kidney failure     protein-energy malnutrition     Cancer
    Thalassemia     Proteinuria     Lung disease     Diabetes mellitus
    Cholera     Hemosiderosis     Vascular disease     Atransferrinemia
    Alcohol dependence     protein-losing enteropathy     Brain disease     Porphyria cutanea tarda

    TF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for TF gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron deficiency 92.5 238 17376421 (4), 19283067 (3), 18971604 (3), 8167189 (3) (see all 99)
    iron overload 92.2 174 18720534 (3), 11427792 (3), 17679134 (3), 7745107 (3) (see all 99)
    hemochromatosis 90.8 140 9496946 (6), 12190182 (5), 18201677 (2), 16451136 (2) (see all 99)
    hereditary hemochromatosis 89.9 43 11027676 (2), 17038583 (2), 8168821 (1), 12547236 (1) (see all 34)
    anemia 84 147 10556206 (3), 20098432 (2), 2224400 (2), 10460349 (2) (see all 99)
    iron deficiency anemia 82.4 41 17682669 (2), 20209848 (2), 9492551 (2), 1486679 (2) (see all 29)
    carbohydrate-deficient glycoprotein syndrome 77.4 11 1472054 (1), 7884970 (1), 12880136 (1), 8981095 (1) (see all 10)
    malnutrition 71.9 35 9469497 (3), 8793418 (1), 11147687 (1), 16234837 (1) (see all 30)
    response acute phase 71 17 9074650 (2), 11176144 (1), 10681647 (1), 9915269 (1) (see all 12)
    african iron overload 66.6 6 14515008 (2), 11017929 (2), 1727237 (1)

    Genatlas disease: TF
    hypotransferrinemia,familial

    Genetic Association Database (GAD): TF
    Human Genome Epidemiology (HuGE) Navigator: TF (346 documents)

    Export disorders for TF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TF gene, integrated from 9 sources (see all 2846):
    (articles sorted by number of sources associating them with TF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. (PubMed id 11703331)1, 2, 4 Lee P.L.... Beutler E. (2001)
    2. Human transferrin: cDNA characterization and chromosomal localization. (PubMed id 6585826)1, 2, 3 Yang F.... Bowman B.H. (1984)
    3. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. (PubMed id 10931525)1, 2, 9 de Arriba Zerpa G.A.... Baron B. (2000)
    4. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. (PubMed id 20029940)1, 4, 9 Kauwe J.S....Goate A.M. (2010)
    5. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4, 9 Benyamin B....Visscher P.M. (2009)
    6. Iron genes, iron load and risk of Alzheimer's disease. (PubMed id 17047092)1, 4, 9 Lehmann D.J....Robson K.J. (2006)
    7. Iron metabolism genes, low-level lead exposure, and QT interval. (PubMed id 19165391)1, 4, 9 Park S.K....Weisskopf M.G. (2009)
    8. Genetic variants of transferrin in cystic fibrosis. (PubMed id 18344013)1, 4, 9 Marklova E....Vavrova V. (2008)
    9. Soluble transferrin receptor and mutations in hemochromatosis and transferrin genes in a general Catalan population. (PubMed id 15698609)1, 4, 9 Berez V....Joven J. (2005)
    10. [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4, 9 Spitsyn V.A....Afanas'eva I.S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7018 HGNC: 11740 AceView: TF Ensembl:ENSG00000091513 euGenes: HUgn7018
    ECgene: TF Kegg: 7018 H-InvDB: TF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TF Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Transferrin
    SeattleSNPshttp://pga.gs.washington.edu/data/tf/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TF gene:
    Search GeneIP for patents involving TF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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