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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TF Gene

protein-coding GIFtS: 71
GCID: GC03P133464

transferrin

Explore 271 diseases affiliated with
TF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transferrin³		TFQTL1²
Transferrin³		Serotransferrin¹
PRO1557¹ ²		Siderophilin³
PRO2086¹ ²		Siderophilin³
Beta-1 Metal-Binding Globulin² ³		EC 3.4.21⁸

External Ids:	HGNC: 11740¹	Entrez Gene: 7018²	Ensembl: ENSG00000091513⁷	OMIM: 190000⁵	UniProtKB: P02787³

Export aliases for TF gene to outside databases

Previous GC identifers: GC03P130424 GC03P134209 GC03P134746 GC03P134786 GC03P134727 GC03P134947 GC03P133419 GC03P130844

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TF:

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created

as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of

which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine,

reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also

have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter

and allergens from serum. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the

binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and

heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating

cell proliferation

Gene Wiki entry for TF (Transferrin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TF gene promoter:
HOXA9 HOXA9B NRSF form 1 FOXD3 NRSF form 2 HNF-3beta Meis-1b AREB6 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): TF promoter sequence

Search SABiosciences Chromatin IP Primers for TF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q21

TF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TF gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P133464: view genomic region (about GC identifiers)

Start:	133,464,800 bp from pter	End:	133,497,850 bp from pter
Size:	33,051 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787 (See protein sequence)

Recommended Name: Serotransferrin precursor

Size: 698 amino acids; 77064 Da

Subunit: Monomer

Subcellular location: Secreted

Sequence caution: Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

6/33 PDB 3D structures from and Proteopedia for TF (see all 33):

1A8E (3D)

1A8F (3D)

1B3E (3D)

1BP5 (3D)

1BTJ (3D)

1D3K (3D)

Secondary accessions: O43890 Q1HBA5 Q9NQB8 Q9UHV0

Explore the universe of human proteins at neXtProt for TF: NX_P02787

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02787

4 DME Specific Peptides for TF (P02787)

GDVAFVK

GKKSCHT

YSGAFKCL

KADRDQYELLC

TF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001054.1

ENSEMBL proteins:

ENSP00000385834 ENSP00000417468 ENSP00000401505 ENSP00000419338 ENSP00000418716

ENSP00000418396 ENSP00000419714 ENSP00000264998

Reactome Protein details: P02787
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TF (Holo-Transferrin)
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	OriGene Purified Protein: TF OriGene Protein Over-expression Lysate: TF OriGene Custom Protein Services for TF
	GenScript Custom Purified and Recombinant Proteins Services for TF
	Novus Biologicals TF Proteins Novus Biologicals TF Lysates
	Sino Biological Recombinant Protein for TF
	ProSpec Recombinant Protein for TF
	Uscn Proteins for TF

Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005739	mitochondrion	IDA	--
GO:0005769	early endosome	IDA	15880641
GO:0005770	late endosome	IDA	15880641
GO:0005905	coated pit	IDA	12857860

TF for ontologies About GeneDecksing

TF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TF
	R&D Systems Antibodies for TF (Transferrin)
	OriGene Antibodies (see all 2): TF OriGene Custom Antibody Services for TF
	GenScript Superior Antibodies for TF
	Novus Biologicals TF Antibodies
	Abcam antibodies for TF
	Uscn Antibodies for TF
	ThermoFisher Antibody for TF

Assay Products for TF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TF for domains About GeneDecksing

3 InterPro domains/families:

IPR001156 Transferrin_fam

IPR018195 Transferrin_Fe_BS

IPR016357 Transferrin

Graphical View of Domain Structure for InterPro Entry P02787

ProtoNet protein and cluster: P02787

1 Blocks protein family: IPB001156 Transferrin

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Similarity: Belongs to the transferrin family

Similarity: Contains 2 transferrin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the

binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and

heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating

cell proliferation

Genatlas biochemistry entry for TF:

transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3

Enzyme Number (IUBMB): EC 3.4.21²

Summary:

TF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Embryoid bodies , White adipocyte-like cells (see all 7).

miRNA Products:		OriGene 3'-UTR Clone: TF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TF
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TF:
		hsa-miR-186
		SwitchGear 3'UTR luciferase reporter plasmid: TF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TF (see all 4) OriGene shRNA RFP: TF OriGene siRNA: TF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: TF (NM_005171)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TF
		Search LifeMap BioReagents cell lines for TF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TF

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15880641
GO:0008199	ferric iron binding	IEA	--
GO:0031625	ubiquitin protein ligase binding	IEA	--

TF for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for TF:

Increased G1 DNA content

Increased cell death HMECs cel

Increased number of mitotic ce

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trf):

growth/size

hematopoietic system

homeostasis/metabolism

mortality/aging

TF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Insulin receptor recycling

Transferrin endocytosis and recycling

0.79

Iron uptake and transport

0.56

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TF

	Selected targets of ESR1
	Selected targets of C/EBPalpha

4 BioSystems Pathways for TF

	SIDS Susceptibility Pathways
	iron metabolism in placenta
	HIF-1-alpha transcription factor network
	EPHB forward signaling

5/7 Reactome Pathways for TF (see all 7)

	Hemostasis
	Transmembrane transport of small molecules
	Platelet degranulation
	Iron uptake and transport
	Platelet activation, signaling and aggregation

1 Kegg Pathway (Kegg details for TF):

Mineral absorption

TF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/87 Interacting proteins for TF (P02787^{2, 3} ENSP00000264998⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 87)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HFE	Q30201²^,³, ENSP00000417404⁴	MINT-7896348 MINT-7896317 MINT-7896366 MINT-7896258 MINT-7896330 I2D: score=2 STRING: ENSP00000417404
GAST	P01350²^,³, ENSP00000331358⁴	MINT-7212849 MINT-7212881 MINT-7212832 MINT-7212864 MINT-7212909 I2D: score=1 STRING: ENSP00000331358
CALR	P27797³, ENSP00000320866⁴	I2D: score=3 STRING: ENSP00000320866
TFR2	Q9UP52³, ENSP00000223051⁴	I2D: score=3 STRING: ENSP00000223051
ENSG00000258947	Q13509³	I2D: score=2

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006826	iron ion transport	--	--
GO:0006879	cellular iron ion homeostasis	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--

TF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TF

4 HMDB Compounds for TF About this table

Compound	Synonyms	CAS #	PubMed Ids
Bismuth	Bi (see all 2)	7440-69-9	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Hydrogen carbonate	Bicarbonate (see all 19)	71-52-3	--
Iron	Armco iron (see all 19)	7439-89-6	--

4 DrugBank Compounds for TF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Bismuth Subsalicylate	Bismuth (see all 6)	14882-18-9	carrier	--	11110794 15519234 15544343 12620681 17330963
Iron Dextran	Dexferrum (see all 2)	9004-66-4	carrier	substrate	272031 10084288 11576368 2208657 17316146
Aluminium	--	7429-90-5	target	--	11327511 17629565 16301797 16139893
Gallium nitrate	--	13494-90-1	carrier	substrate	19621374 18475921 16373528

10/127 Novoseek chemical compound relationships for TF gene (see all 127) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	95.5	6347	15292463 (9), 10556206 (8), 10945243 (8), 8623803 (8) (see all 99)
apotransferrin	89.4	58	16925790 (2), 7508710 (2), 8151309 (2), 1769555 (1) (see all 44)
iron sucrose	88.5	51	11071973 (5), 8918625 (3), 19010259 (2), 14767009 (2) (see all 29)
iron dextran	79.5	16	9398141 (2), 9415935 (2), 7611266 (1), 1522796 (1) (see all 13)
ferric gluconate	76.1	9	17267740 (1), 19260610 (1), 19034302 (1), 8671901 (1) (see all 7)
fe3+	74.1	78	15231685 (8), 19820086 (3), 10945247 (2), 11128996 (2) (see all 49)
deferoxamine	70.7	69	8306330 (6), 1649718 (2), 1629195 (2), 8280612 (2) (see all 37)
ferric ammonium citrate	70.4	29	11335103 (4), 1629195 (2), 7488642 (2), 9657901 (2) (see all 11)
protoporphyrin ix	68.9	62	1519605 (4), 7832579 (2), 1619469 (2), 2044721 (1) (see all 56)
kp-1019	68.9	6	16440400 (3), 18512673 (1), 18433763 (1), 16603249 (1)

Search CenterWatch for drugs/clinical trials and news about TF / TRFE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TF gene:

NM_001063.3

Unigene Cluster for TF:

Transferrin

Hs.518267 [show with all ESTs]

Unigene Representative Sequence: CR936810

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000402696(uc003epu.2 uc011bls.1 uc003epv.2 uc011blt.2 uc003epw.2)

ENST00000466911 ENST00000474287 ENST00000414694 ENST00000482271 ENST00000460531

ENST00000485977 ENST00000494430 ENST00000493011 ENST00000475382 ENST00000498622

ENST00000461695 ENST00000462495 ENST00000467842 ENST00000264998

miRNA Products:		OriGene 3'-UTR Clone: TF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TF
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TF:
		hsa-miR-186
		SwitchGear 3'UTR luciferase reporter plasmid: TF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TF (see all 4) OriGene shRNA RFP: TF OriGene siRNA: TF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TF (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TF (NM_005171)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TF Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TF

Additional cDNA sequence:

AF118093.1 AJ252279.1 AK222755.1 AK293842.1 AK295334.1 AK295419.1 AK303753.1 AK312094.1

BC020671.1 BC045772.1 BC059367.1 BX648533.1 CR936810.1 DQ923758.1 M12525.1 M12530.1

M26641.1 S95936.1 U88581.1

24/47 DOTS entries (see all 47):

DT.101987325 DT.100888172 DT.100888145 DT.100888157 DT.100888151 DT.40265225 DT.97864666 DT.40115686

DT.99970516 DT.97864665 DT.100888152 DT.98131781 DT.40125951 DT.91968032 DT.120892237 DT.120892195

DT.120892183 DT.100888164 DT.120892071 DT.100888165 DT.120892212 DT.100888169 DT.91914782 DT.92457961

24/826 AceView cDNA sequences (see all 826):

BQ635968 BU729784 AI978566 BM672205 BU733019 BM668827 BQ637232 CA443678

BU730278 BM703517 BM669884 BP359977 BU727000 CA390515 T71595 T75011

AI174903 BU726750 AI133433 N62765 BQ639058 BU726734 BU728620 BM666900

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TF (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	^
SP1:									-								-		-																										-		-
SP2:									-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:			-		-		-		-								-		-
SP4:									-
SP5:																	-		-

ExUns:	17	^	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCTGAAC

About this image

TF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Hypoblast

Extraembryonic Endoderm

Extraembryonic Endoderm Cells

Extraembryonic Tissues, Yolk Sac

Hypoblast

Parietal Endoderm Cells

Extraembryonic Tissues

Adipose

Visceral White Adipose

Adipose

Bone

Zeugopod Periosteum

Bone

Heart

Atrioventricular Canal

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Embryoid bodies (Two-step protocol fo...)

See TF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TF

SOURCE GeneReport for Unigene cluster: Hs.518267

UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Tissue specificity: Expressed by the liver and secreted in plasma

SABiosciences Custom PCR Arrays for TF

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TF gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LTF¹	lactotransferrin	60.26(n) 53.67(a)		396241 NM_205304.1 NP_990635.1
lizard (Anolis carolinensis)	Reptilia	--	--	35(a)	1 → many	3(30950579-30982630)
zebrafish (Danio rerio)	Actinopterygii	Dr.28538²	Transcribed sequence	79.31(n)		CF722973.1
fruit fly (Drosophila melanogaster)	Insecta	Tsf2⁶ Tsf1⁶ (see all 3)	Transferrin 1 (see all 3)	27(a) 22(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3L(12523536-12526824) X(18281965-18284377)

ENSEMBL Gene Tree for TF (if available)
TreeFam Gene Tree for TF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TF gene

MFI2² LTF²

3 SIMAP similar genes for TF using alignment to 11 protein entries: TRFE_HUMAN (see all proteins):

LTF GIG12 MFI2

TF for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TF
PGOHUM00000259871 PGOHUM00000259872 PGOHUM00000259873

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Polymorphism: Different polymorphic variants of transferrin are known. The sequence shown is the predominant

electrophoretic variant (C1 or TF*C1)

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121918677^1,2	C,F,	pathogenic	251982364(+)	`CTTAGG/AAGAAG`	2	/E /G	mis¹		2		NA EU	5869
rs1049296^1,2	C,F,H,	pathogenic	251984042(+)	`GGAAAC/TCTGTG`	2	P S	mis¹ ese³		54		NS MN EA NA WA CSA EU	11880
rs41295774^1,2	C,F,	pathogenic	252001699(+)	`TGCCCA/GCGGGT`	2	H R	mis¹		7		NS NA EU	6199
rs1799899^1,2	C,F,H,	unknown	252002585(+)	`TGGGCG/AGCAAG`	2	/S /G	mis¹		24		NS MN EA NA EU	8181
rs8177180^1,2	C,F,H,	--	130843173(+)	`GGTGAG/AGCTGA`	1	--	us2k¹		7		NS EA WA	622
rs73217213^1,2		--	130843431(+)	`CCTTTC/GAGGTG`	1	--	us2k¹		0	--	--	--	--
rs11717885^1,2	H	--	130843480(+)	`gtgaaA/Cagggg`	1	--	us2k¹ trp³		4		NS EA	420
rs6765211^1,2	C,F,H,	--	130843600(+)	`cttcaC/Tgagat`	1	--	us2k¹		6		NS EA	508
rs8177313^1,2	C,F,H,	--	130843760(+)	`ATGAAT/GGACCA`	1	--	us2k¹		17		NS EA NA	2308
rs8177314^1,2	C,F,H,	--	130843850(+)	`CTTTCC/ACCAAG`	1	--	us2k¹ tfbs³		8		NS EA NA	626

HapMap Linkage Disequilibrium report for TF (133464800 - 133497850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TF: --
Human Gene Mutation Database (HGMD): TF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TF

DNA2.0 Custom Variant and Variant Library Synthesis for TF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TF for disorders           About GeneDecksing

OMIM gene information: 190000
OMIM disorders: 209300
UniProtKB/Swiss-Prot: TRFE_HUMAN, P02787

Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal

recessive disorder characterized by iron overload and hypochromic anemia

20/271 diseases for TF (see all 271): About MalaCards

protein-energy malnutrition porphyria cutanea tarda protein-losing enteropathy pure red-cell aplasia

hyperferritinemia-cataract syndrome iron overload rosai-dorfman disease superficial siderosis of the central nervous system

steroid-resistant nephrotic syndrome congenital nephrotic syndrome finnish type restless legs syndrome hypochromic microcytic anemia

microcytic anemia pyruvate kinase deficiency end stage renal failure attention deficit hyperactivity disorder

erythropoietic protoporphyria retinol binding protein focal segmental glomerulosclerosis age related macular degeneration

20 diseases from the University of Copenhagen DISEASES database for TF:

Hemochromatosis Anemia Substance abuse Congenital disorder of glycosylation

Liver disease Kidney failure protein-energy malnutrition Thalassemia

Cancer Proteinuria Hemosiderosis Lung disease

Diabetes mellitus Cholera Atransferrinemia Vascular disease

Alcohol dependence Porphyria cutanea tarda protein-losing enteropathy Brain disease

10/97 Novoseek disease relationships for TF gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iron deficiency	92.5	238	17376421 (4), 19283067 (3), 18971604 (3), 8167189 (3) (see all 99)
iron overload	92.2	174	18720534 (3), 11427792 (3), 17679134 (3), 7745107 (3) (see all 99)
hemochromatosis	90.8	140	9496946 (6), 12190182 (5), 18201677 (2), 16451136 (2) (see all 99)
hereditary hemochromatosis	89.9	43	11027676 (2), 17038583 (2), 8168821 (1), 12547236 (1) (see all 34)
anemia	84	147	10556206 (3), 20098432 (2), 2224400 (2), 10460349 (2) (see all 99)
iron deficiency anemia	82.4	41	17682669 (2), 20209848 (2), 9492551 (2), 1486679 (2) (see all 29)
carbohydrate-deficient glycoprotein syndrome	77.4	11	1472054 (1), 7884970 (1), 12880136 (1), 8981095 (1) (see all 10)
malnutrition	71.9	35	9469497 (3), 8793418 (1), 11147687 (1), 16234837 (1) (see all 30)
response acute phase	71	17	9074650 (2), 11176144 (1), 10681647 (1), 9915269 (1) (see all 12)
african iron overload	66.6	6	14515008 (2), 11017929 (2), 1727237 (1)

Genatlas disease: TF

hypotransferrinemia,familial

Genetic Association Database (GAD): TF
Human Genome Epidemiology (HuGE) Navigator: TF (346 documents)

Export disorders for TF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TF gene, integrated from 9 sources (see all 2836):
(articles sorted by number of sources associating them with TF)

Utopia: connect your pdf to the dynamic
world of online information

Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. (PubMed id 11703331)^{1, 2, 4} Lee P.L.... Beutler E. (2001)
Human transferrin: cDNA characterization and chromosomal localization. (PubMed id 6585826)^{1, 2, 3} Yang F.... Bowman B.H. (1984)
Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. (PubMed id 10931525)^{1, 2, 9} de Arriba Zerpa G.A.... Baron B. (2000)
Soluble transferrin receptor and mutations in hemochromatosis and transferrin genes in a general Catalan population. (PubMed id 15698609)^{1, 4, 9} Berez V....Joven J. (2005)
[Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)^{1, 4, 9} Spitsyn V.A....Afanas'eva I.S. (2001)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{1, 2} Ramachandran P....Loo J.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Molecular characterization of a third case of human atransferrinemia. (PubMed id 15466165)^{1, 2} Knisely A.S.... Beutler E. (2004)
Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans. (PubMed id 15648851)^{1, 4} Scheil H.G....Huckenbeck W. (2004)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{1, 2} Bunkenborg J.... Wisniewski J.R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7018	HGNC: 11740	AceView: TF	Ensembl:ENSG00000091513	euGenes: HUgn7018
ECgene: TF	Kegg: 7018	H-InvDB: TF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Transferrin
SeattleSNPs	http://pga.gs.washington.edu/data/tf/

Intellectual Property for TF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TF gene:
Search GeneIP for patents involving TF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Mono- and Polyclonal Antibodies for the study of TF
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TF Gene

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Congenital Disorders
Fatty Liver
Microalbuminuria
WILSON DISEASE
Severe malnutrition
Porphyria
Protein-Energy Malnutrition
AFRICAN IRON OVERLOAD
CEREBELLAR HYPOPLASIA
Hepatitis Chronic
childhood Hodgkins disease
Anemia Hemolytic
Erythroleukemia
Vitreoretinopathy Proliferative
Hereditary hemochromatosis
PROTEIN MALNUTRITION
Liver diseases
Intoxication
Iron deficiency anemia
Respiratory Distress Syndrome
Siderosis
Nephrotic Syndrome
nutritional deficit
Neck Cancer
Alcohol abuse
Hemolysis
MICROCYTIC ANEMIA
RENAL DISEASE
Alcoholic Cirrhosis
Malnutrition
Inflammation
Diabetic Nephropathies
iron deficiency
Proteinuria
Marasmus
SICKLE CELL DISEASE
Anemia
ANEMIA SEVERE
Renal Failure
LIVER DAMAGE
nutritional deficiency
Liver Cirrhosis
metabolic disorder
Hemosiderosis
Hepatitis C
Chronic Disease
CDG Ia
Nephrotic Syndrome Minimal Change
Cirrhosis
arthropathy
Anemia Macrocytic
atherosclerotic plaque
Liver Fibrosis
Lung Diseases Interstitial
Thalassemia
Thalassemia Major
Bacterial Infections
ANEMIA, HYPOCHROMIC MICROCYTIC
Trypanosomiasis African
Diabetes Mellitus
hypoalbuminemia
Intermedia thalassemia
Alcoholism
beta-Thalassemia
HEPATOCELLULAR CARCINOMA
Hepatitis Chronic Active
Oligozoospermia
Hypersensitivity Delayed
Iron Disorder
Uremia
Albuminuria
ATRANSFERRINEMIA
HYPOCHROMIA
Response Acute Phase
HYPERFERRITINEMIA-CATARACT SYNDROME
Restless Legs Syndrome
Diphtheria
Liver Dysfunction
Hypoproteinemia
Hemoglobinopathies
Liver Diseases Alcoholic
HEMOCHROMATOSIS SECONDARY
Carbohydrate-Deficient Glycoprotein Syndrome
Porphyria Cutanea Tarda
nutritional disorder
Hepatitis C Chronic
Acute respiratory distress
Hemochromatosis
FUNCTION LIVER ABNORMAL
Iron Overload
chronic liver disease
Cholera
genetic disorder
Myelodysplastic Syndromes
Anemia Hemolytic Congenital
Renal Failure Chronic
Hypogonadism

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TF Gene

transferrin

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