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Aliases for TF Gene

Aliases for TF Gene

  • Transferrin 2 3 4
  • Beta-1 Metal-Binding Globulin 3 4
  • Siderophilin 3 4
  • TFQTL1 3 6
  • Serotransferrin 3
  • EC 3.4.21 63
  • PRO1557 3
  • PRO2086 3

External Ids for TF Gene

Previous GeneCards Identifiers for TF Gene

  • GC03P130424
  • GC03P134209
  • GC03P134746
  • GC03P134786
  • GC03P134727
  • GC03P134947
  • GC03P133419
  • GC03P130844
  • GC03P133464

Summaries for TF Gene

Entrez Gene Summary for TF Gene

  • This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

GeneCards Summary for TF Gene

TF (Transferrin) is a Protein Coding gene. Diseases associated with TF include atransferrinemia and siderosis. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include ubiquitin protein ligase binding and ferric iron binding. An important paralog of this gene is MFI2.

UniProtKB/Swiss-Prot for TF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

Gene Wiki entry for TF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TF Gene

Genomics for TF Gene

Regulatory Elements for TF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TF Gene

Start:
133,745,956 bp from pter
End:
133,779,006 bp from pter
Size:
33,051 bases
Orientation:
Plus strand

Genomic View for TF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TF Gene

Proteins for TF Gene

  • Protein details for TF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02787-TRFE_HUMAN
    Recommended name:
    Serotransferrin
    Protein Accession:
    P02787
    Secondary Accessions:
    • O43890
    • Q1HBA5
    • Q9NQB8
    • Q9UHV0

    Protein attributes for TF Gene

    Size:
    698 amino acids
    Molecular mass:
    77064 Da
    Quaternary structure:
    • Monomer
    SequenceCaution:
    • Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TF Gene

neXtProt entry for TF Gene

Proteomics data for TF Gene at MOPED

Selected DME Specific Peptides for TF Gene

Post-translational modifications for TF Gene

  • Glycosylation at Ser51, Asn432, Asn491, and Asn630
  • Modification sites at PhosphoSitePlus

Other Protein References for TF Gene

Antibody Products

Domains for TF Gene

Protein Domains for TF Gene

Suggested Antigen Peptide Sequences for TF Gene

Graphical View of Domain Structure for InterPro Entry

P02787

UniProtKB/Swiss-Prot:

TRFE_HUMAN :
  • P02787
Domain:
  • Contains 2 transferrin-like domains.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with TF: view

No data available for Gene Families for TF Gene

Function for TF Gene

Molecular function for TF Gene

GENATLAS Biochemistry:
transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3
UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

Enzyme Numbers (IUBMB) for TF Gene

LifeMap Function Summary for TF Gene

TF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15880641
GO:0008199 ferric iron binding IEA --
GO:0015091 ferric iron transmembrane transporter activity IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with TF: view
genes like me logo Genes that share phenotypes with TF: view

miRNA for TF Gene

miRTarBase miRNAs that target TF

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TF Gene

Localization for TF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TF Gene COMPARTMENTS Subcellular localization image for TF gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
mitochondrion 4
golgi apparatus 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005769 early endosome IDA 15880641
GO:0005770 late endosome IDA 15880641
GO:0005905 coated pit IDA 12857860
genes like me logo Genes that share ontologies with TF: view

Pathways for TF Gene

genes like me logo Genes that share pathways with TF: view

Gene Ontology (GO) - Biological Process for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002576 platelet degranulation TAS --
GO:0006826 iron ion transport --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with TF: view

Compounds for TF Gene

(4) HMDB Compounds for TF Gene

Compound Synonyms Cas Number PubMed IDs
Bismuth
  • Bi
7440-69-9
Heme
  • (protoporphyrinato)iron
14875-96-8
Hydrogen carbonate
  • Bicarbonate
71-52-3
Iron
  • Armco iron
7439-89-6

(4) Drugbank Compounds for TF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aluminium
7429-90-5 target
Bismuth Subsalicylate
  • Bismuth
14882-18-9 carrier
Gallium nitrate
13494-90-1 carrier substrate
Iron Dextran
  • Dexferrum
9004-66-4 carrier substrate

(127) Novoseek inferred chemical compound relationships for TF Gene

Compound -log(P) Hits PubMed IDs
iron 95.5 502
apotransferrin 89.4 47
iron sucrose 88.5 38
iron dextran 79.5 15
ferric gluconate 76.1 7
genes like me logo Genes that share compounds with TF: view

Transcripts for TF Gene

Unigene Clusters for TF Gene

Transferrin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TF Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6:
SP7: - - -
SP8:

ExUns: 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TF Gene

GeneLoc Exon Structure for
TF
ECgene alternative splicing isoforms for
TF

Expression for TF Gene

mRNA expression in normal human tissues for TF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TF Gene

This gene is overexpressed in Liver (19.0), Brain - Spinal cord (cervical c-1) (13.3), and Brain - Substantia nigra (5.4).

Protein differential expression in normal tissues for TF Gene

This gene is overexpressed in Vitreous humor (10.4), Plasma (7.7), and Cerebrospinal fluid (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TF Gene

SOURCE GeneReport for Unigene cluster for TF Gene Hs.518267

mRNA Expression by UniProt/SwissProt for TF Gene

P02787-TRFE_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with TF: view

Expression partners for TF Gene

In Situ Assay Products

Orthologs for TF Gene

This gene was present in the common ancestor of animals.

Orthologs for TF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TF 35
  • 77.7 (n)
  • 69.93 (a)
TF 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TF 35
  • 80.32 (n)
  • 73.23 (a)
TF 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trf 35
  • 78.15 (n)
  • 74.1 (a)
Trf 16
Gm20425 36
  • 51 (a)
OneToMany
Trf 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TF 35
  • 99.38 (n)
  • 99.43 (a)
TF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tf 35
  • 77.28 (n)
  • 73.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves TF 35
  • 60.26 (n)
  • 53.67 (a)
TF 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tf 35
  • 59.25 (n)
  • 51.49 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28538 35
tfa 35
  • 53.8 (n)
  • 48.28 (a)
tfa 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4617 36
  • 31 (a)
ManyToMany
Species with no ortholog for TF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TF Gene

ENSEMBL:
Gene Tree for TF (if available)
TreeFam:
Gene Tree for TF (if available)

Paralogs for TF Gene

Paralogs for TF Gene

Pseudogenes.org Pseudogenes for TF Gene

genes like me logo Genes that share paralogs with TF: view

Variants for TF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TF Gene

P02787-TRFE_HUMAN
Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1)

Sequence variations from dbSNP and Humsavar for TF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7845 -- 133,768,144(+) TACTA(C/G/T)GGCTA reference, stop-gained, synonymous-codon
rs8649 -- 133,768,114(+) AACCT(C/G)TGTGA synonymous-codon, reference
rs11553 -- 133,778,591(+) CACTC(C/T)TGGAA reference, synonymous-codon
rs11877 -- 133,778,668(+) CAGAT(G/T)ATCCA utr-variant-3-prime
rs12595 -- 133,777,709(-) CAAAC(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TF Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897
nsv877507 CNV Loss 21882294
nsv877508 CNV Loss 21882294
nsv4018 CNV Loss 18451855

Relevant External Links for TF Gene

HapMap Linkage Disequilibrium report
TF
Human Gene Mutation Database (HGMD)
TF

Disorders for TF Gene

(1) OMIM Diseases for TF Gene (190000)

UniProtKB/Swiss-Prot

TRFE_HUMAN
  • Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO:0000269 PubMed:11110675, ECO:0000269 PubMed:15466165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for TF Gene

Disease -log(P) Hits PubMed IDs
iron deficiency 92.5 124
iron overload 92.2 122
hemochromatosis 90.8 119
hereditary hemochromatosis 89.9 36
anemia 84 109

Genatlas disease for TF Gene

hypotransferrinemia,familial

Relevant External Links for TF

Genetic Association Database (GAD)
TF
Human Genome Epidemiology (HuGE) Navigator
TF
genes like me logo Genes that share disorders with TF: view

Publications for TF Gene

  1. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. (PMID: 10931525) de Arriba Zerpa G.A. … Baron B. (J. Neurosci. Res. 2000) 3 4 23
  2. Genetic variants of transferrin in cystic fibrosis. (PMID: 18344013) MarklovA! E. … VA!vrovA! V. (J. Inherit. Metab. Dis. 2008) 3 23 48
  3. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 23 48
  4. Iron metabolism genes, low-level lead exposure, and QT interval. (PMID: 19165391) Park S.K. … Weisskopf M.G. (Environ. Health Perspect. 2009) 3 23 48
  5. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. (PMID: 20029940) Kauwe J.S. … Goate A.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48

Products for TF Gene

Sources for TF Gene

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