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TEX9 Gene

protein-coding   GIFtS: 41
GCID: GC15P056536

Testis Expressed 9

(Previous name: testis expressed sequence 9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 91 2
Testis Expressed Sequence 91
Testis-Expressed Sequence 9 Protein2

External Ids:    HGNC: 295851   Entrez Gene: 3746182   Ensembl: ENSG000001515757   UniProtKB: Q8N6V93   

Export aliases for TEX9 gene to outside databases

Previous GC identifers: GC15P054445 GC15P056658 GC15P033481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX9 Gene:
TEX9 (testis expressed 9) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX9 gene promoter:
         MEF-2   FOXO3   FOXO3b   MEF-2A   E2F-1   FOXO4   FOXO3a   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX9 promoter sequence
   Search Chromatin IP Primers for TEX9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

TEX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX9 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P056536:  view genomic region     (about GC identifiers)

Start:
56,536,207 bp from pter      End:
56,738,195 bp from pter
Size:
201,989 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TEX9_HUMAN, Q8N6V9 (See protein sequence)
Recommended Name: Testis-expressed sequence 9 protein  
Size: 391 amino acids; 44826 Da

Explore the universe of human proteins at neXtProt for TEX9: NX_Q8N6V9

Explore proteomics data for TEX9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273378.1  NP_940926.1  

    ENSEMBL proteins: 
     ENSP00000452791   ENSP00000342169   ENSP00000438745   ENSP00000456593   ENSP00000453431  
     ENSP00000453398   ENSP00000453960  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N6V9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TEX9

    miRNA
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    Block miRNA regulation of human, mouse, rat TEX9 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TEX9:
    hsa-miR-4328 hsa-miR-3117-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidTEX9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    Find genes that share ontologies with TEX9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX9
    Interactions:

        Search GeneGlobe Interaction Network for TEX9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TEX9 (Q8N6V92, 3 ENSP000003421694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC112Q8NEF32, 3, ENSP000003689314MINT-66828 I2D: score=4 STRING: ENSP00000368931
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with TEX9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX9 gene (2 alternative transcripts): 
    NM_001286449.1  NM_198524.2  

    Unigene Cluster for TEX9:

    Testis expressed 9
    Hs.511476  [show with all ESTs]
    Unigene Representative Sequence: AL832050
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560827 ENST00000352903(uc002adp.3) ENST00000537232(uc010ugl.2)
    ENST00000561221 ENST00000558127 ENST00000558083(uc002adq.1) ENST00000559142
    ENST00000559546 ENST00000560582
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TEX9:
    hsa-miR-4328 hsa-miR-3117-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidTEX9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TEX9
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX9
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEX9
      QuantiTect SYBR Green Assays in human, mouse, rat TEX9
      QuantiFast Probe-based Assays in human, mouse, rat TEX9

    Additional mRNA sequence: 

    AK094529.1 AK294960.1 AL832050.1 BC028119.1 

    11 DOTS entries:

    DT.100020819  DT.104221  DT.100812277  DT.91643457  DT.92362889  DT.100703038  DT.121055854  DT.91986418 
    DT.95346870  DT.99983112  DT.99976787 

    Selected AceView cDNA sequences (see all 33):

    NM_198524 BQ130565 AW085295 BC028119 AA969086 BU177233 CR621164 BX361954 
    BG538698 CK905873 BX645750 AL832050 BU852678 AW453005 BQ130819 BU570187 
    BI831028 BF679012 BI766739 AW503502 AA279396 BI551223 AA020919 AW104283 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TEX9    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for TEX9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TEX9 Expression
    About this image


    TEX9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    TEX9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511476
        Custom PCR Arrays for TEX9
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEX9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex91 , 5 testis expressed gene 91, 5 81.35(n)1
    76.94(a)1
      9 (40.08 cM)5
    217781  NM_009359.41  NP_033385.21 
     724503945 
    chicken
    (Gallus gallus)
    Aves TEX91 testis expressed 9 68.82(n)
    59.68(a)
      425342  XM_423114.4  XP_423114.4 
    lizard
    (Anolis carolinensis)
    Reptilia TEX96
    testis expressed 9
    59(a)
    1 ↔ 1
    GL343573.1(459491-461216)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.80112 Transcribed sequences 76.79(n)    AL884067.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144252 Transcribed sequence with weak similarity to protein more 75.47(n)    CK028160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46816
    --
    20(a)
    1 ↔ 1
    2R(20465770-20467304)


    ENSEMBL Gene Tree for TEX9 (if available)
    TreeFam Gene Tree for TEX9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX9 (see all 1425)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389431081,2
    --56655657(+) CCACCA/GCGCCT 1 -- us2k10--------
    rs1418880461,2
    --56655658(+) CACCGC/TGCCTG 1 -- us2k10--------
    rs777261911,2
    C,F--56655732(+) AATTTT/GCATTT 1 -- us2k11Minor allele frequency- G:0.13WA 118
    rs1181256241,2
    C,F--56655787(+) CTTGTA/GTATGT 1 -- us2k11Minor allele frequency- G:0.05NA 120
    rs1457513131,2
    --56655858(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs791745911,2
    C,F--56655940(+) CTCTTT/AGCAGC 1 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1386194661,2
    --56656002(+) GGACTA/GCAGGC 1 -- us2k10--------
    rs125933481,2
    C,F,H--56656006(+) tacagG/Tcatgt 1 -- us2k12Minor allele frequency- T:0.25WA EA 238
    rs2022381761,2
    C--56656048(+) TTTTT-/TGTAGA 1 -- us2k10--------
    rs351552901,2
    C,F--56656063(+) TTTTGT/GAGAGA 1 -- us2k17Minor allele frequency- G:0.21NA WA EA 366

    HapMap Linkage Disequilibrium report for TEX9 (56536207 - 56738195 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TEX9 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665975CNV Deletion23128226
    dgv10n31CNV Deletion19718026
    esv2660653CNV Deletion23128226
    esv1244240CNV Insertion17803354
    esv2525559CNV Loss19546169
    nsv9270CNV Loss18304495
    nsv433294CNV Loss18776910
    esv24258CNV Loss19812545
    nsv498847CNV Loss21111241
    nsv510662CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX9 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEX9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PubMed id 24068947)1 Brandler W.M....Paracchini S. (PLoS Genet. 2013)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374618 HGNC: 29585 AceView: LOC161577 Ensembl:ENSG00000151575 euGenes: HUgn374618
    ECgene: TEX9 H-InvDB: TEX9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX9 gene:
    Search GeneIP for patents involving TEX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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