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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX9 Gene

protein-coding   GIFtS: 41
GCID: GC15P056536

testis expressed 9

(Previous name: testis expressed sequence 9 )
  Search for TEX9
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TEX9    

Aliases
for TEX9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Testis Expressed 91 2
Testis Expressed Sequence 91 2
Testis-Expressed Sequence 9 Protein2

External Ids:    HGNC: 295851   Entrez Gene: 3746182   Ensembl: ENSG000001515757   UniProtKB: Q8N6V93   

Export aliases for TEX9 gene to outside databases

Previous GC identifers: GC15P054445 GC15P056658 GC15P033481


Summaries
for TEX9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TEX9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX9 gene promoter:
         MEF-2   FOXO3   FOXO3b   MEF-2A   E2F-1   FOXO4   FOXO3a   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEX9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

TEX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX9 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P056536:  view genomic region     (about GC identifiers)

Start:
 56,536,207 bp from pter      End:
 56,738,195 bp from pter
Size:
 201,989 bases      Orientation:
 plus strand

Proteins
for TEX9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TEX9_HUMAN, Q8N6V9 (See protein sequence)
Recommended Name: Testis-expressed sequence 9 protein  
Size: 391 amino acids; 44826 Da

Explore the universe of human proteins at neXtProt for TEX9: NX_Q8N6V9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N6V9

    • TEX9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940926.1  
    ENSEMBL proteins: 
     ENSP00000452791   ENSP00000342169   ENSP00000438745   ENSP00000456593   ENSP00000453431  
     ENSP00000453398   ENSP00000453960  

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    Uscn Proteins for TEX9


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    Protein Domains /
    Families
    for TEX9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N6V9


    Function
    for TEX9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX9:
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    SwitchGear 3'UTR luciferase reporter plasmid: TEX9 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for TEX9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TEX9 (Q8N6V92, 3 ENSP000003421694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC112Q8NEF32, 3, ENSP000003689314MINT-66828 I2D: score=4 STRING: ENSP00000368931
    About this table

    Drugs & Compounds
    for TEX9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX9
    Search CenterWatch for drugs/clinical trials and news about TEX9 

    Transcripts
    for TEX9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TEX9 gene: 
    NM_198524.1  

    Unigene Cluster for TEX9:

    Testis expressed 9
    Hs.511476  [show with all ESTs]
    Unigene Representative Sequence: AL832050
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560827 ENST00000352903(uc002adp.3) ENST00000537232(uc010ugl.2)
    ENST00000561221 ENST00000558127 ENST00000558083(uc002adq.1) ENST00000559142
    ENST00000559546 ENST00000560582

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX9:
    hsa-miR-4328 hsa-miR-3117-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmid: TEX9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEX9 (see all 4)
    OriGene shRNA RFP: TEX9
    OriGene siRNA: TEX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX9
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX9 
    Primer
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    Additional cDNA sequence: 

    AK094529.1 AK294960.1 AL832050.1 BC028119.1 

    11 DOTS entries:

    DT.100020819  DT.104221  DT.100812277  DT.91643457  DT.92362889  DT.100703038  DT.121055854  DT.91986418 
    DT.95346870  DT.99983112  DT.99976787 

    24/33 AceView cDNA sequences (see all 33):

    BQ130565 NM_198524 AA969086 CR621164 BC028119 BU177233 AW085295 BG538698 
    BI831028 BX645750 AW453005 BU570187 BU852678 BX361954 CK905873 BQ130819 
    AL832050 AA279396 BI551223 BF679012 BI766739 BX370290 AW104283 AA020919 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TEX9    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for TEX9

    Expression
    for TEX9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TEX9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See TEX9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX9

    SOURCE GeneReport for Unigene cluster: Hs.511476
        SABiosciences Custom PCR Arrays for TEX9
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX9

    Orthologs
    for TEX9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TEX9 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tex91 , 5 testis expressed gene 91, 5 81.35(n)1
    76.94(a)1    		   9 (40.08 cM)5
    217781  NM_009359.41  NP_033385.21 
     724580555 
    chicken
    (Gallus gallus)    		 Aves TEX91 testis expressed 9 72.22(n)
    65.38(a)    		   425342  XM_423114.3  XP_423114.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TEX96
    		 --
    		 59(a)
    		 1 ↔ 1
    		 GL343573.1(459491-461216)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.80112 Transcribed sequences 76.79(n)    AL884067.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.144252 Transcribed sequence with weak similarity to protein more 75.47(n)    CK028160.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG46811 CG4681 38.46(n)
    23.78(a)    		   37928  NM_138093.3  NP_611937.2 


    ENSEMBL Gene Tree for TEX9 (if available)
    TreeFam Gene Tree for TEX9 (if available) 

    Paralogs
    for TEX9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TEX9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1219 NCBI SNPs in TEX9 are shown (see all 1219)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1389431081,2
    		--56655657(+) CCACCA/GCGCCT 1 -- us2k10--------
    rs1418880461,2
    		--56655658(+) CACCGC/TGCCTG 1 -- us2k10--------
    rs777261911,2
    		F,--56655732(+) AATTTT/GCATTT 1 -- us2k11Minor allele frequency- G:0.13WA 118
    rs1181256241,2
    		C,F,--56655787(+) CTTGTA/GTATGT 1 -- us2k11Minor allele frequency- G:0.05NA 120
    rs1457513131,2
    		--56655858(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs791745911,2
    		F,--56655940(+) CTCTTT/AGCAGC 1 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1386194661,2
    		--56656002(+) GGACTA/GCAGGC 1 -- us2k10--------
    rs125933481,2
    		C,F,H,--56656006(+) TACAGG/TCATGT 1 -- us2k12Minor allele frequency- T:0.25WA EA 238
    rs351552901,2
    		C,F,--56656063(+) TTTTGT/GAGAGA 1 -- us2k17Minor allele frequency- G:0.21NA WA EA 366
    rs2020181801,2
    		--56656135(+) CTTAG-/CCTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEX9 (56536207 - 56738195 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for TEX9
         11 CNVs: 87691 102107 9265 66811 76971 35323 32038 87689 87690 3083 37526
         1 Indel: 60177

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    Disorders / Diseases
    for TEX9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TEX9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for TEX9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TEX9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374618 HGNC: 29585 AceView: LOC161577 Ensembl:ENSG00000151575 euGenes: HUgn374618
    ECgene: TEX9 H-InvDB: TEX9

    Other Databases showing TEX9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TEX9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TEX9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TEX9 gene:
    Search GeneIP for patents involving TEX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TEX9 gene

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    Advanced Cell Diagnostics
    About This Section

     
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