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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX37 Gene

protein-coding   GIFtS: 37
GCID: GC02P088825

testis expressed 37

(Previous name: chromosome 2 open reading frame 51 )
(Previous symbol: C2orf51)
  Search for TEX37
in our new
 Human Malady Compendium 
Biological research products
for TEX37
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Testis Expressed 371 2     Chromosome 2 Open Reading Frame 511
C2orf511 2 3     Protein TSC212
TSC211 2 3     Testis-Expressed Sequence 37 Protein2
Testis-Specific Conserved Protein Of 21 KDa2 3     Testis-Specific Conserved Gene 21kDa2
FLJ253691     

External Ids:    HGNC: 263411   Entrez Gene: 2005232   Ensembl: ENSG000001720737   UniProtKB: Q96LM63   

Export aliases for TEX37 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX37
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TEX37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TEX37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX37 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088825:  view genomic region     (about GC identifiers)

Start:
88,824,169 bp from pter      End:
88,829,103 bp from pter
Size:
4,935 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEX37_HUMAN, Q96LM6 (See protein sequence)
Recommended Name: Testis-expressed sequence 37 protein  
Size: 180 amino acids; 20615 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TEX37: NX_Q96LM6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96LM6

  • TEX37 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689883.1  
    ENSEMBL proteins: 
     ENSP00000307142  

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    Uscn Proteins for TEX37

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TEX37 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TEX37


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LM6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    1 GenomeRNAi human phenotype for TEX37:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX37

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TEX37 (Q96LM62, 3 ENSP000003071424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930622, 3, ENSP000003401764MINT-67584 I2D: score=4 STRING: ENSP00000340176
    TRIP13Q156452, 3, ENSP000001663454MINT-66415 I2D: score=4 STRING: ENSP00000166345
    MAGEA11P433642, 3, ENSP000003473584MINT-67525 I2D: score=4 STRING: ENSP00000347358
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX37
    Search CenterWatch for drugs/clinical trials and news about TEX37 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX37 gene: 
    NM_152670.2  

    Unigene Cluster for TEX37:

    Testis expressed 37
    Hs.132104  [show with all ESTs]
    Unigene Representative Sequence: NM_152670
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303254(uc002stb.2)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEX37 (see all 4)
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    OriGene siRNA: TEX37
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX37
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    Additional cDNA sequence: 

    AK058098.1 BC029522.1 

    2 DOTS entries:

    DT.102145  DT.100657270 

    22 AceView cDNA sequences:

    CR607082 BP369367 BX104224 BP371206 AI041108 BX492796 BX377494 AK058098 
    BX327991 BI562305 BX377495 NM_152670 AW104588 BC029522 BE537481 AA907947 
    AI382142 BE843354 AL576285 BE843361 BE843353 BQ374505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    See TEX37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX37

    SOURCE GeneReport for Unigene cluster: Hs.132104

    UniProtKB/Swiss-Prot: TEX37_HUMAN, Q96LM6
    Tissue specificity: Testis-specific

        SABiosciences Custom PCR Arrays for TEX37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TEX37 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex371 , 5 RIKEN cDNA 1700011F03 gene5
    testis expressed 371
    77.41(n)1
    70(a)1
      6 (32.12 cM)5
    742211  NM_028825.31  NP_083101.11 
     709130875 


    ENSEMBL Gene Tree for TEX37 (if available)
    TreeFam Gene Tree for TEX37 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 NCBI SNPs in TEX37 are shown (see all 179    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890439451,2
    --88822188(+) CATGCG/TGGGGA 1 -- us2k10--------
    rs1814830151,2
    --88822328(+) CTTGCC/TCATCA 1 -- us2k10--------
    rs1162837211,2
    F,--88822701(+) CACAAA/TAGAAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1163980361,2
    --88822840(+) TATATA/GTTTAA 1 -- us2k10--------
    rs1152173491,2
    --88822842(+) TATGTA/TTAATA 1 -- us2k10--------
    rs1495430411,2
    --88822894(+) TAAAAC/TATATA 1 -- us2k10--------
    rs558613901,2
    C,F,--88822941(+) AAGTTT/CATCAT 1 -- us2k16Minor allele frequency- C:0.17WA NA EA 364
    rs1154165161,2
    F,--88822958(+) CACTTT/ATAAGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1134960941,2
    --88822994(+) TTCACA/CATGGG 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1872688311,2
    --88823091(+) CTCTCC/TTCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEX37 (88824169 - 88829103 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TEX37: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX37 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characteristics of a novel testis-specific gene, Tsc21, in mice and human. (PubMed id 17091336)1, 2, 3 Yu Z.... Cai Z. (2007)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200523 HGNC: 26341 AceView: FLJ25369 Ensembl:ENSG00000172073 euGenes: HUgn200523
    ECgene: TEX37 H-InvDB: TEX37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX37 gene:
    Search GeneIP for patents involving TEX37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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