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TEX37 Gene

protein-coding   GIFtS: 34
GCID: GC02P088825

Testis Expressed 37

(Previous name: chromosome 2 open reading frame 51)
(Previous symbol: C2orf51)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 371 2     TSC212 3
C2orf511 2 3     Chromosome 2 Open Reading Frame 511
Testis-Specific Conserved Gene 21kDa1 2     Protein TSC212
Testis-Specific Conserved Protein Of 21 KDa2 3     Testis-Expressed Sequence 37 Protein2

External Ids:    HGNC: 263411   Entrez Gene: 2005232   Ensembl: ENSG000001720737   UniProtKB: Q96LM63   

Export aliases for TEX37 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX37 Gene:
TEX37 (testis expressed 37) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TEX37
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TEX37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX37 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088825:  view genomic region     (about GC identifiers)

Start:
88,824,169 bp from pter      End:
88,829,103 bp from pter
Size:
4,935 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TEX37_HUMAN, Q96LM6 (See protein sequence)
Recommended Name: Testis-expressed sequence 37 protein  
Size: 180 amino acids; 20615 Da

Explore the universe of human proteins at neXtProt for TEX37: NX_Q96LM6

Explore proteomics data for TEX37 at MOPED


See TEX37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689883.1  
ENSEMBL proteins: 
 ENSP00000307142  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96LM6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for TEX37:
 Increased gamma-H2AX phosphory 

     1 MGI phenotypic allele for Tex37 (no phenotypes)

Find genes that share phenotypes with TEX37           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TEX37

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TEX37_HUMAN, Q96LM6: Nucleus (By similarity)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with TEX37           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX37
Interactions:

    Search GeneGlobe Interaction Network for TEX37

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TEX37 (Q96LM62, 3 ENSP000003071424) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RBPMSQ930622, 3, ENSP000003401764MINT-67584 I2D: score=4 STRING: ENSP00000340176
TRIP13Q156452, 3, ENSP000001663454MINT-66415 I2D: score=4 STRING: ENSP00000166345
MAGEA11P433642, 3, ENSP000003473584MINT-67525 I2D: score=4 STRING: ENSP00000347358
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TEX37



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TEX37 gene: 
NM_152670.2  

Unigene Cluster for TEX37:

Testis expressed 37
Hs.132104  [show with all ESTs]
Unigene Representative Sequence: NM_152670
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000303254(uc002stb.2)
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Additional mRNA sequence: 

AK058098.1 BC029522.1 

2 DOTS entries:

DT.102145  DT.100657270 

22 AceView cDNA sequences:

BP371206 CR607082 BP369367 BX104224 BX377495 BC029522 AW104588 BI562305 
BX492796 AK058098 AI041108 BX327991 NM_152670 BX377494 BE537481 AI382142 
AA907947 AL576285 BE843354 BE843353 BE843361 BQ374505 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEX37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TEX37 Expression
About this image

TEX37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TEX37 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.132104

UniProtKB/Swiss-Prot: TEX37_HUMAN, Q96LM6
Tissue specificity: Testis-specific

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TEX37 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tex371 , 5 RIKEN cDNA 1700011F03 gene5
testis expressed 371
77.41(n)1
70(a)1
  6 (32.12 cM)5
742211  NM_028825.31  NP_083101.11 
 709130875 


ENSEMBL Gene Tree for TEX37 (if available)
TreeFam Gene Tree for TEX37 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TEX37 (see all 234)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1890439451,2
--88822188(+) CATGCG/TGGGGA 1 -- us2k10--------
rs1814830151,2
--88822328(+) CTTGCC/TCATCA 1 -- us2k10--------
rs1162837211,2
F--88822701(+) CACAAA/TAGAAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs1163980361,2
--88822840(+) TATATA/GTTTAA 1 -- us2k10--------
rs1152173491,2
--88822842(+) TATGTA/TTAATA 1 -- us2k10--------
rs1495430411,2
--88822894(+) TAAAAC/TATATA 1 -- us2k10--------
rs558613901,2
C,F--88822941(+) AAGTTT/CATCAT 1 -- us2k16Minor allele frequency- C:0.17WA NA EA 364
rs1154165161,2
C,F--88822958(+) CACTTT/ATAAGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1134960941,2
F--88822994(+) TTCACA/CATGGG 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
rs1872688311,2
--88823091(+) CTCTCC/TTCAGT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TEX37 (88824169 - 88829103 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TEX37: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TEX37
DNA2.0 Custom Variant and Variant Library Synthesis for TEX37

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TEX37 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TEX37)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characteristics of a novel testis-specific gene, Tsc21, in mice and human. (PubMed id 17091336)1, 2, 3 Yu Z.... Cai Z. (Mol. Biol. Rep. 2007)
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 200523 HGNC: 26341 AceView: FLJ25369 Ensembl:ENSG00000172073 euGenes: HUgn200523
ECgene: TEX37 H-InvDB: TEX37

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TEX37 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TEX37 gene:
Search GeneIP for patents involving TEX37

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from genOway)
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