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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX36 Gene

protein-coding   GIFtS: 31
GCID: GC10M127265

Testis Expressed 36

(Previous name: chromosome 10 open reading frame 122)
(Previous symbol: C10orf122)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 361 2
C10orf1221 2 3
Chromosome 10 Open Reading Frame 1221
bA383C5.12
Testis-Expressed Sequence 36 Protein2

External Ids:    HGNC: 316531   Entrez Gene: 3877182   Ensembl: ENSG000001750187   UniProtKB: Q5VZQ53   

Export aliases for TEX36 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX36 Gene: 
TEX36 (testis expressed 36) is a protein-coding gene. Diseases associated with TEX36 include fatty liver disease, and liver disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX36
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TEX36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

TEX36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX36 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M127265:  view genomic region     (about GC identifiers)

Start:
127,265,091 bp from pter      End:
127,371,713 bp from pter
Size:
106,623 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX36_HUMAN, Q5VZQ5 (See protein sequence)
Recommended Name: Testis-expressed sequence 36 protein  
Size: 186 amino acids; 21545 Da
Secondary accessions: Q0P5T8

Explore the universe of human proteins at neXtProt for TEX36: NX_Q5VZQ5

Explore proteomics data for TEX36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VZQ5

  • TEX36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX36 Protein Expression
    REFSEQ proteins: NP_001121674.1  
    ENSEMBL proteins: 
     ENSP00000431764   ENSP00000434299   ENSP00000357811  

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5VZQ5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX36 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX36

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TEX36 (ENSP000003578114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CCENSP000003350844STRING: ENSP00000335084
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX36

    Search CenterWatch for drugs/clinical trials and news about TEX36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX36 gene: 
    NM_001128202.1  

    Unigene Cluster for TEX36:

    Testis expressed 36
    Hs.148259  [show with all ESTs]
    Unigene Representative Sequence: BC062717
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532135(uc001lij.3) ENST00000526819 ENST00000368821(uc001lik.4)

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX36

    Additional mRNA sequence: 

    AK131010.1 BC062717.1 BC127766.1 BC127767.1 

    3 DOTS entries:

    DT.100840844  DT.101979384  DT.40127575 

    9 AceView cDNA sequences:

    CR611441 BC062717 AK131010 AW086452 AW082215 BX336391 AA977508 BQ429237 
    BX390366 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TEX36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX36

    SOURCE GeneReport for Unigene cluster: Hs.148259
        SABiosciences Custom PCR Arrays for TEX36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TEX36 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex361 , 5 RIKEN cDNA 4930404H21 gene5
    testis expressed 361
    73.44(n)1
    62.09(a)1
      7 (77.09 cM)5
    738081  NM_028654.11  NP_082930.11 
     1335870245 
    chicken
    (Gallus gallus)
    Aves C6H10orf1221 chromosome 6 open reading frame, human C10orf122 52.51(n)
    42.47(a)
      768745  XM_001231849.2  XP_001231850.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEX366
    testis expressed 36
    31(a)
    1 ↔ 1
    3(62947470-62966804)


    ENSEMBL Gene Tree for TEX36 (if available)
    TreeFam Gene Tree for TEX36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEX36 gene
    1 SIMAP similar gene for TEX36 using alignment to 3 protein entries:     TEX36_HUMAN (see all proteins):
    C10orf122

    TEX36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/586 SNPs in TEX36 are shown (see all 586)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70702911,2
    C,F,A,H--121063052(+) ACATAG/TCACCT 1 -- us2k14Minor allele frequency- T:0.01NS EA WA 416
    rs1926587401,2
    --127343849(+) TCTCTA/TCTAAA 1 -- int10--------
    rs94227811,2
    --127343928(+) agaatC/Tggtgc 1 -- int10--------
    rs1407174131,2
    --127343936(+) TTGAAC/TCCAGA 1 -- int10--------
    rs124145611,2
    C,F,A,H--127344019(+) AAATTA/TAAAAA 1 -- int110Minor allele frequency- T:0.17NS EA NA WA 774
    rs748736441,2
    C,F--127344038(+) GAATAT/CTTTGC 1 -- int11Minor allele frequency- C:0.09WA 118
    rs105101471,2
    C,F,H--127344072(+) AAAGTT/CTATGT 1 -- int126Minor allele frequency- C:0.06NS EA NA 2606
    rs1833472741,2
    --127344075(+) GTTTAC/TGTGTT 1 -- int10--------
    rs799228871,2
    C,F--127344114(+) ATTAAA/TAACAA 1 -- int11Minor allele frequency- T:0.04NA 120
    rs1446786431,2
    --127344145(+) GACATA/GCAGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TEX36 (127265091 - 127371713 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX36: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX36
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TEX36:    About MalaCards
    fatty liver disease    liver disease


    TEX36 for disorders           About GeneDecksing


    Export disorders for TEX36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX36 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....Silva E.F. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387718 HGNC: 31653 AceView: C10orf122 Ensembl:ENSG00000175018 euGenes: HUgn387718
    ECgene: TEX36 H-InvDB: TEX36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX36 gene:
    Search GeneIP for patents involving TEX36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    transforming growth factor, beta 1
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