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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX35 Gene

protein-coding   GIFtS: 34
GCID: GC01P178484

Testis Expressed 35

(Previous name: chromosome 1 open reading frame 49)
(Previous symbol: C1orf49)
  Search for TEX35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 351 2
C1orf491 2 3
Testis-Specific Conserved Gene 24kDa1 2
Chromosome 1 Open Reading Frame 491
TSC242
Testis-Expressed Sequence 35 Protein2

External Ids:    HGNC: 253661   Entrez Gene: 840662   Ensembl: ENSG000002400217   UniProtKB: Q5T0J73   

Export aliases for TEX35 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX35 Gene: 
TEX35 (testis expressed 35) is a protein-coding gene.

Gene Wiki entry for TEX35 (C1orf49) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX35
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TEX35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

TEX35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX35 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P178484:  view genomic region     (about GC identifiers)

Start:
178,482,212 bp from pter      End:
178,517,734 bp from pter
Size:
35,523 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX35_HUMAN, Q5T0J7 (See protein sequence)
Recommended Name: Testis-expressed sequence 35 protein  
Size: 233 amino acids; 26518 Da
Secondary accessions: Q5T0J8 Q5T0J9 Q8IYU6 Q8N7Z1 Q8NA15 Q9H0Q7
Alternative splicing: 5 isoforms:  Q5T0J7-1   Q5T0J7-2   Q5T0J7-3   Q5T0J7-4   Q5T0J7-5   

Explore the universe of human proteins at neXtProt for TEX35: NX_Q5T0J7

Explore proteomics data for TEX35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T0J7

  • TEX35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX35 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001164193.1  NP_001164194.1  NP_001164195.1  NP_115502.2  

    ENSEMBL proteins: 
     ENSP00000323795   ENSP00000356615   ENSP00000356614   ENSP00000356613   ENSP00000430720  
     ENSP00000356611   ENSP00000413991   ENSP00000258298  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0015630microtubule cytoskeleton IDA--

    TEX35 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T0J7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX35 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX35

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX35

    Search CenterWatch for drugs/clinical trials and news about TEX35

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX35 gene (4 alternative transcripts): 
    NM_001170722.1  NM_001170723.1  NM_001170724.1  NM_032126.4  

    Unigene Cluster for TEX35:

    Testis expressed 35
    Hs.534501  [show with all ESTs]
    Unigene Representative Sequence: BM563719
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319416(uc001glt.2) ENST00000367643(uc021pfd.1) ENST00000367642
    ENST00000367641(uc001glu.1) ENST00000419909(uc001glv.1) ENST00000367639(uc021pfe.1 uc001glw.2)
    ENST00000442872 ENST00000258298
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AL136694.1 BC034972.2 

    7 DOTS entries:

    DT.100749676  DT.100749677  DT.95160899  DT.40205058  DT.95160902  DT.70101845  DT.100021195 

    24/34 AceView cDNA sequences (see all 34):

    AK093269 AX748023 AI240606 NM_207467 BQ778206 BI825350 AI762835 BG773295 
    CK902294 BG719876 AK092849 BE041517 BG772571 BI464425 AX747765 AL136694 
    NM_032126 BM563719 BC034972 BI825610 AK097518 AI692881 AA383469 BX359643 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TEX35 Expression
    About this image


    See TEX35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX35

    SOURCE GeneReport for Unigene cluster: Hs.534501

    UniProtKB/Swiss-Prot: TEX35_HUMAN, Q5T0J7
    Tissue specificity: Testis-specific

        SABiosciences Custom PCR Arrays for TEX35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TEX35 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex351 , 5 RIKEN cDNA 1700057K13 gene5
    testis expressed 351
    74.24(n)1
    60.61(a)1
      1 (67.97 cM)5
    734351  NM_028540.21  NP_082816.11 
     1570991485 


    ENSEMBL Gene Tree for TEX35 (if available)
    TreeFam Gene Tree for TEX35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEX35 gene
    1 SIMAP similar gene for TEX35 using alignment to 3 protein entries:     E5RIH0_HUMAN (see all proteins):
    Tex35

    TEX35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/305 SNPs in TEX35 are shown (see all 305)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502057001,2
    --178480285(+) GGATCC/TCTTGA 4 -- us2k10--------
    rs96588831,2
    C,F,A--178480315(+) GCCTGA/GGCAAC 4 -- us2k18Minor allele frequency- G:0.23NA WA CSA EA 367
    rs96599061,2
    C,F--178480334(+) accttG/Atctcc 4 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1420533721,2
    --178480339(+) GTCTCC/TACAAA 4 -- us2k10--------
    rs1463226541,2
    --178480378(+) GTGGCA/GCATGC 4 -- us2k10--------
    rs1384358061,2
    --178480405(+) ACAGGA/GTGCTG 4 -- us2k10--------
    rs1850693751,2
    --178480461(+) CCATGA/TTCATA 4 -- us2k10--------
    rs1910637191,2
    --178480554(+) TTCCCC/TCAGCC 4 -- us2k10--------
    rs1496226161,2
    --178480593(+) TGTACA/CATGTT 4 -- us2k10--------
    rs1827860041,2
    --178480619(+) TAAACG/TCTGTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEX35 (178482212 - 178517734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX35: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TEX35
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX35 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TEX35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characteristics of a novel testis-specific gene, Tsc24, in human and mice. (PubMed id 17077512)1, 2, 3 Tang A....Cai Z. (2006)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84066 HGNC: 25366 AceView: DKFZP564J047andFLJ35530 Ensembl:ENSG00000240021 euGenes: HUgn84066
    ECgene: TEX35 H-InvDB: TEX35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX35 gene:
    Search GeneIP for patents involving TEX35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for TEX35
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     Search LifeMap BioReagents cell lines for TEX35
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     ThermoFisher Antibody for TEX35
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX35
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX35
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TEX35
    Customized:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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