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TEX35 Gene

protein-coding   GIFtS: 34
GCID: GC01P178484

Testis Expressed 35

(Previous name: chromosome 1 open reading frame 49)
(Previous symbol: C1orf49)
  Search for TEX35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 351 2
C1orf491 2 3
Testis-Specific Conserved Gene 24kDa1 2
Chromosome 1 Open Reading Frame 491
TSC242
Testis-Expressed Sequence 35 Protein2

External Ids:    HGNC: 253661   Entrez Gene: 840662   Ensembl: ENSG000002400217   UniProtKB: Q5T0J73   

Export aliases for TEX35 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX35 Gene:
TEX35 (testis expressed 35) is a protein-coding gene.

Gene Wiki entry for TEX35 (C1orf49) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TEX35
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TEX35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

TEX35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX35 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P178484:  view genomic region     (about GC identifiers)

Start:
178,482,212 bp from pter      End:
178,517,734 bp from pter
Size:
35,523 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEX35_HUMAN, Q5T0J7 (See protein sequence)
Recommended Name: Testis-expressed sequence 35 protein  
Size: 233 amino acids; 26518 Da
Secondary accessions: Q5T0J8 Q5T0J9 Q8IYU6 Q8N7Z1 Q8NA15 Q9H0Q7
Alternative splicing: 5 isoforms:  Q5T0J7-1   Q5T0J7-2   Q5T0J7-3   Q5T0J7-4   Q5T0J7-5   

Explore the universe of human proteins at neXtProt for TEX35: NX_Q5T0J7

Explore proteomics data for TEX35 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001164193.1  NP_001164194.1  NP_001164195.1  NP_115502.2  

    ENSEMBL proteins: 
     ENSP00000323795   ENSP00000356615   ENSP00000356614   ENSP00000356613   ENSP00000430720  
     ENSP00000356611   ENSP00000413991   ENSP00000258298  

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    Search eBioscience for ELISAs for TEX35 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027874 Tex35

    Graphical View of Domain Structure for InterPro Entry Q5T0J7

    ProtoNet protein and cluster: Q5T0J7


    Find genes that share domains with TEX35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX35
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEX35

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with TEX35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX35
    Interactions:

        Search GeneGlobe Interaction Network for TEX35

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX35



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX35 gene (4 alternative transcripts): 
    NM_001170722.1  NM_001170723.1  NM_001170724.1  NM_032126.4  

    Unigene Cluster for TEX35:

    Testis expressed 35
    Hs.534501  [show with all ESTs]
    Unigene Representative Sequence: BM563719
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319416(uc001glt.2) ENST00000367643(uc021pfd.1) ENST00000367642
    ENST00000367641(uc001glu.1) ENST00000419909(uc001glv.1) ENST00000367639(uc021pfe.1 uc001glw.2)
    ENST00000442872 ENST00000258298
    miRNA
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    Additional mRNA sequence: 

    AL136694.1 BC034972.2 

    7 DOTS entries:

    DT.100749676  DT.100749677  DT.95160899  DT.40205058  DT.95160902  DT.70101845  DT.100021195 

    Selected AceView cDNA sequences (see all 34):

    AI240606 AK093269 AX748023 BI825350 BG719876 BX359643 AL136694 AK097518 
    AK092849 AI692881 AX747765 NM_207467 BG772571 NM_032126 BE041517 AI762835 
    BQ778206 BI464425 CK902294 AW340027 BI825610 BG773295 BM563719 BC034972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TEX35 Expression
    About this image

    TEX35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534501

    UniProtKB/Swiss-Prot: TEX35_HUMAN, Q5T0J7
    Tissue specificity: Testis-specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TEX35 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex351 , 5 RIKEN cDNA 1700057K13 gene5
    testis expressed 351
    74.79(n)1
    60.41(a)1
      1 (67.97 cM)5
    734351  NM_028540.21  NP_082816.11 
     1570991485 


    ENSEMBL Gene Tree for TEX35 (if available)
    TreeFam Gene Tree for TEX35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEX35 gene
    1 SIMAP similar gene for TEX35 using alignment to 3 protein entries:     E5RIH0_HUMAN (see all proteins):
    Tex35

    Find genes that share paralogs with TEX35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX35 (see all 305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502057001,2
    --178480285(+) GGATCC/TCTTGA 4 -- us2k10--------
    rs96588831,2
    C,F,A--178480315(+) GCCTGA/GGCAAC 4 -- us2k18Minor allele frequency- G:0.23NA WA CSA EA 367
    rs96599061,2
    C,F--178480334(+) accttG/Atctcc 4 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1420533721,2
    --178480339(+) GTCTCC/TACAAA 4 -- us2k10--------
    rs1463226541,2
    --178480378(+) GTGGCA/GCATGC 4 -- us2k10--------
    rs1384358061,2
    --178480405(+) ACAGGA/GTGCTG 4 -- us2k10--------
    rs1850693751,2
    --178480461(+) CCATGA/TTCATA 4 -- us2k10--------
    rs1910637191,2
    --178480554(+) TTCCCC/TCAGCC 4 -- us2k10--------
    rs1496226161,2
    --178480593(+) TGTACA/CATGTT 4 -- us2k10--------
    rs1827860041,2
    --178480619(+) TAAACG/TCTGTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEX35 (178482212 - 178517734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX35: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TEX35
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX35 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TEX35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characteristics of a novel testis-specific gene, Tsc24, in human and mice. (PubMed id 17077512)1, 2, 3 Tang A.... Cai Z. (Biol. Pharm. Bull. 2006)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84066 HGNC: 25366 AceView: DKFZP564J047andFLJ35530 Ensembl:ENSG00000240021 euGenes: HUgn84066
    ECgene: TEX35 H-InvDB: TEX35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX35 gene:
    Search GeneIP for patents involving TEX35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     See all of Abcam's Antibodies, Kits and Proteins for TEX35
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TEX35
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX35
     SwitchGear 3'UTR luciferase reporter plasmids for TEX35
     Browse SwitchGear Promoter luciferase reporter plasmids for TEX35
     ThermoFisher Antibody for TEX35
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX35
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX35
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEX35
     LSBio Antibodies in human, mouse, rat for TEX35
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TEX35
      Search eBioscience for proteins for TEX35
      Search eBioscience for elisas for TEX35
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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