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TEX33 Gene

protein-coding   GIFtS: 34
GCID: GC22M037388

Testis Expressed 33

(Previous name: chromosome 22 open reading frame 33)
(Previous symbol: C22orf33)
  Search for TEX33
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 331 2     cE81G9.22
C22orf331 2 3     Protein EAN572
EAN572 3     Testis-Expressed Sequence 33 Protein2
Chromosome 22 Open Reading Frame 331     

External Ids:    HGNC: 285681   Entrez Gene: 3396692   Ensembl: ENSG000001852647   UniProtKB: O432473   

Export aliases for TEX33 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX33 Gene:
TEX33 (testis expressed 33) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TEX33
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX33 promoter sequence
   Search Chromatin IP Primers for TEX33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

TEX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX33 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037388:  view genomic region     (about GC identifiers)

Start:
37,387,160 bp from pter      End:
37,403,882 bp from pter
Size:
16,723 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEX33_HUMAN, O43247 (See protein sequence)
Recommended Name: Testis-expressed sequence 33 protein  
Size: 280 amino acids; 30725 Da
Sequence caution: Sequence=CAA72029.1; Type=Erroneous gene model prediction;
Secondary accessions: B1AH46 Q6ICF2 Q8IVQ2 Q9Y4V8
Alternative splicing: 2 isoforms:  O43247-1   O43247-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEX33: NX_O43247

Explore proteomics data for TEX33 at MOPED


See TEX33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001157329.1  NP_848647.1  

ENSEMBL proteins: 
 ENSP00000406640   ENSP00000385179   ENSP00000386118   ENSP00000371243  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: O43247


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX33
Interactions:

    Search GeneGlobe Interaction Network for TEX33

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for TEX33



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TEX33 gene (2 alternative transcripts): 
NM_001163857.1  NM_178552.3  

Unigene Cluster for TEX33:

Testis expressed 33
Hs.124502  [show with all ESTs]
Unigene Representative Sequence: BC042635
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000442538 ENST00000402860 ENST00000405091(uc003aqf.3 uc003aqe.3)
ENST00000381821
miRNA
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Additional mRNA sequence: 

BC042635.1 CR456416.1 

3 DOTS entries:

DT.407689  DT.40127101  DT.95142044 

17 AceView cDNA sequences:

AI028336 AA846324 CR456416 AA412232 BX282036 AI028335 AA861567 BE502000 
BE466644 AA868959 AI138357 BE671960 BI825426 NM_178552 BC042635 BI829995 
BI827796 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TEX33    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1:                                                
SP2:              -                                 


ECgene alternative splicing isoforms for TEX33

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEX33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGGAAGAC
TEX33 Expression
About this image


TEX33 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Testis (Reproductive System)
         Mature Sertoli Cells Seminiferous Tubules
TEX33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TEX33 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.124502
    Custom PCR Arrays for TEX33
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TEX33 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tex331 , 5 RIKEN cDNA 1700061J05 gene5
testis expressed 331
77.11(n)1
67.17(a)1
  15 (37.45 cM)5
733761  NM_001163612.21  NP_001157084.11 
 783784005 
chicken
(Gallus gallus)
Aves TEX336
testis expressed 33
46(a)
1 ↔ 1
1(51362972-51367986)


ENSEMBL Gene Tree for TEX33 (if available)
TreeFam Gene Tree for TEX33 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TEX33 (see all 526)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1440451541,2
C--37386679(+) TGGCCC/TAAATT 2 -- ds50010--------
rs1485871541,2
C--37386768(+) TCAAA-/AA    
   AAC
/C
CCCGC
2 -- ds50010--------
rs57564631,2
C,F--37386794(+) AATGTG/ATGTGG 2 -- ds50016Minor allele frequency- A:0.36NA CSA WA EA 364
rs1931730731,2
--37386825(+) GTCTCA/GTGGGG 2 -- ds50010--------
rs1120307311,2
C--37386845(+) ATGTCC/TGGGAA 2 -- ds50011Minor allele frequency- T:0.50CSA 2
rs7138291,2
C,F,A,H--37386920(+) TCACAT/CAGGGC 2 -- ds500125Minor allele frequency- C:0.20NA EA NS WA CSA 2764
rs1850209301,2
--37386964(+) CAGAGC/TCATGC 2 -- ds50010--------
rs1131359651,2
F--37386994(+) CTGGGA/GTAATG 2 -- ds50013Minor allele frequency- G:0.03CSA WA 122
rs1890763071,2
--37386999(+) ATAATA/GGATGA 2 -- ds50010--------
rs286332621,2
C--37387029(+) TGTGTG/TCAGGA 2 -- ds50012Minor allele frequency- T:0.06WA 120

HapMap Linkage Disequilibrium report for TEX33 (37387160 - 37403882 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TEX33: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TEX33
DNA2.0 Custom Variant and Variant Library Synthesis for TEX33

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TEX33 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TEX33)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of testis 14-3-3 binding proteins by tandem affinity purification. (PubMed id 22332119)1, 3 Puri P....Vijayaraghavan S. (Spermatogenesis 2011)
  2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339669 HGNC: 28568 AceView: MGC35206 Ensembl:ENSG00000185264 euGenes: HUgn339669
ECgene: TEX33 H-InvDB: TEX33

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TEX33 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TEX33 gene:
Search GeneIP for patents involving TEX33

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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