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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX33 Gene

protein-coding   GIFtS: 36
GCID: GC22M037388

testis expressed 33

(Previous name: chromosome 22 open reading frame 33 )
(Previous symbol: C22orf33)
  Search for TEX33
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TEX33    

Aliases
for TEX33 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Testis Expressed 331 2     Chromosome 22 Open Reading Frame 331
C22orf331 2 3     CE81G9.21
EAN571 2 3     Protein EAN572
MGC352061     Testis-Expressed Sequence 33 Protein2

External Ids:    HGNC: 285681   Entrez Gene: 3396692   Ensembl: ENSG000001852647   UniProtKB: O432473   

Export aliases for TEX33 gene to outside databases


Summaries
for TEX33 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TEX33 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX33
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEX33 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

TEX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX33 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037388:  view genomic region     (about GC identifiers)

Start:
 37,387,160 bp from pter      End:
 37,403,882 bp from pter
Size:
 16,723 bases      Orientation:
 minus strand

Proteins
for TEX33 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TEX33_HUMAN, O43247 (See protein sequence)
Recommended Name: Testis-expressed sequence 33 protein  
Size: 280 amino acids; 30725 Da
Sequence caution: Sequence=CAA72029.1; Type=Erroneous gene model prediction;
Secondary accessions: B1AH46 Q6ICF2 Q8IVQ2 Q9Y4V8
Alternative splicing: 2 isoforms:  O43247-1   O43247-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEX33: NX_O43247

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43247

    • TEX33 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157329.1  NP_848647.1  

    ENSEMBL proteins: 
     ENSP00000406640   ENSP00000385179   ENSP00000386118   ENSP00000371243  

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    Protein Domains /
    Families
    for TEX33 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43247


    Function
    for TEX33 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for TEX33 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX33

    Drugs & Compounds
    for TEX33 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX33
    Search CenterWatch for drugs/clinical trials and news about TEX33 

    Transcripts
    for TEX33 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TEX33 gene (2 alternative transcripts): 
    NM_001163857.1  NM_178552.3  

    Unigene Cluster for TEX33:

    Testis expressed 33
    Hs.124502  [show with all ESTs]
    Unigene Representative Sequence: BC042635
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442538 ENST00000402860 ENST00000405091(uc003aqf.3 uc003aqe.3)
    ENST00000381821

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC042635.1 CR456416.1 

    3 DOTS entries:

    DT.407689  DT.40127101  DT.95142044 

    17 AceView cDNA sequences:

    AI028335 CR456416 AI028336 AA412232 AA861567 AA846324 BX282036 BE502000 
    AA868959 BI825426 AI138357 BC042635 BE466644 BE671960 NM_178552 BI829995 
    BI827796 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TEX33    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for TEX33

    Expression
    for TEX33 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGAAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TEX33 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for TEX33

    SOURCE GeneReport for Unigene cluster: Hs.124502
        SABiosciences Custom PCR Arrays for TEX33
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX33

    Orthologs
    for TEX33 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TEX33 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tex331 , 5 RIKEN cDNA 1700061J05 gene5
    testis expressed 331    		 77.11(n)1
    67.17(a)1    		   15 (37.45 cM)5
    733761  NM_001163612.21  NP_001157084.11 
     783784005 
    chicken
    (Gallus gallus)    		 Aves C22orf336
    		 Uncharacterized protein
    		 46(a)
    		 1 ↔ 1
    		 1(53373024-53508544)


    ENSEMBL Gene Tree for TEX33 (if available)
    TreeFam Gene Tree for TEX33 (if available) 

    Paralogs
    for TEX33 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TEX33 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/432 NCBI SNPs in TEX33 are shown (see all 432)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1440451541,2
    		--37386679(+) TGGCCC/TAAATT 2 -- ds50010--------
    rs1485871541,2
    		--37386768(+) TCAAA-/CCCCGC 2 -- ds50010--------
    rs57564631,2
    		C,F,--37386794(+) AATGTG/ATGTGG 2 -- ds50016Minor allele frequency- A:0.36NA CSA WA EA 364
    rs1931730731,2
    		--37386825(+) GTCTCA/GTGGGG 2 -- ds50010--------
    rs7138291,2
    		C,F,A,H,--37386920(+) TCACAT/CAGGGC 2 -- ds500125Minor allele frequency- C:0.20NA EA NS WA CSA 2764
    rs1850209301,2
    		--37386964(+) CAGAGC/TCATGC 2 -- ds50010--------
    rs1131359651,2
    		F,--37386994(+) CTGGGA/GTAATG 2 -- ds50013Minor allele frequency- G:0.03CSA WA 122
    rs1890763071,2
    		--37386999(+) ATAATA/GGATGA 2 -- ds50010--------
    rs286332621,2
    		C,--37387029(+) TGTGTG/TCAGGA 2 -- ds50012Minor allele frequency- T:0.06WA 120
    rs1135017391,2
    		F--37387105(+) CCACAC/TATCGG 2 -- ds50011Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for TEX33 (37387160 - 37403882 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TEX33: --

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    Disorders / Diseases
    for TEX33 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TEX33 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX33 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX33)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of testis 14-3-3 binding proteins by t andem affinity purification. (PubMed id 22332119)1, 3 Puri P....Vijayaraghavan S. (2011)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    External Searches for TEX33 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TEX33 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339669 HGNC: 28568 AceView: MGC35206 Ensembl:ENSG00000185264 euGenes: HUgn339669
    ECgene: TEX33 H-InvDB: TEX33

    Other Databases showing TEX33 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TEX33 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX33 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TEX33 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TEX33 gene:
    Search GeneIP for patents involving TEX33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TEX33 gene

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    About This Section

     
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    VWF
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    von Willebrand factor
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