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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX33 Gene

protein-coding   GIFtS: 34
GCID: GC22M037388

Testis Expressed 33

(Previous name: chromosome 22 open reading frame 33)
(Previous symbol: C22orf33)
  Search for TEX33
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 331 2     cE81G9.22
C22orf331 2 3     Protein EAN572
EAN572 3     Testis-Expressed Sequence 33 Protein2
Chromosome 22 Open Reading Frame 331     

External Ids:    HGNC: 285681   Entrez Gene: 3396692   Ensembl: ENSG000001852647   UniProtKB: O432473   

Export aliases for TEX33 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX33 Gene: 
TEX33 (testis expressed 33) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX33
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX33 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

TEX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX33 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037388:  view genomic region     (about GC identifiers)

Start:
37,387,160 bp from pter      End:
37,403,882 bp from pter
Size:
16,723 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX33_HUMAN, O43247 (See protein sequence)
Recommended Name: Testis-expressed sequence 33 protein  
Size: 280 amino acids; 30725 Da
Sequence caution: Sequence=CAA72029.1; Type=Erroneous gene model prediction;
Secondary accessions: B1AH46 Q6ICF2 Q8IVQ2 Q9Y4V8
Alternative splicing: 2 isoforms:  O43247-1   O43247-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEX33: NX_O43247

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43247

  • TEX33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157329.1  NP_848647.1  

    ENSEMBL proteins: 
     ENSP00000406640   ENSP00000385179   ENSP00000386118   ENSP00000371243  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43247


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX33 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX33

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX33

    Search CenterWatch for drugs/clinical trials and news about TEX33

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX33 gene (2 alternative transcripts): 
    NM_001163857.1  NM_178552.3  

    Unigene Cluster for TEX33:

    Testis expressed 33
    Hs.124502  [show with all ESTs]
    Unigene Representative Sequence: BC042635
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442538 ENST00000402860 ENST00000405091(uc003aqf.3 uc003aqe.3)
    ENST00000381821
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX33

    Additional mRNA sequence: 

    BC042635.1 CR456416.1 

    3 DOTS entries:

    DT.407689  DT.40127101  DT.95142044 

    17 AceView cDNA sequences:

    CR456416 AA846324 AA861567 AI028336 BX282036 AA412232 AI028335 AI138357 
    BE502000 AA868959 NM_178552 BE671960 BC042635 BE466644 BI825426 BI829995 
    BI827796 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TEX33    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for TEX33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGAAGAC
    TEX33 Expression
    About this image


    Genevestigator expression for TEX33

    SOURCE GeneReport for Unigene cluster: Hs.124502
        SABiosciences Custom PCR Arrays for TEX33
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TEX33 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex331 , 5 RIKEN cDNA 1700061J05 gene5
    testis expressed 331
    77.11(n)1
    67.17(a)1
      15 (37.45 cM)5
    733761  NM_001163612.21  NP_001157084.11 
     783784005 
    chicken
    (Gallus gallus)
    Aves C22ORF336
    Uncharacterized protein
    43(a)
    1 ↔ 1
    1(51362972-51367986)


    ENSEMBL Gene Tree for TEX33 (if available)
    TreeFam Gene Tree for TEX33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 SNPs in TEX33 are shown (see all 526)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440451541,2
    C--37386679(+) TGGCCC/TAAATT 2 -- ds50010--------
    rs1485871541,2
    C--37386768(+) TCAAA-/AA    
       AAC
    /C
    CCCGC
    2 -- ds50010--------
    rs57564631,2
    C,F--37386794(+) AATGTG/ATGTGG 2 -- ds50016Minor allele frequency- A:0.36NA CSA WA EA 364
    rs1931730731,2
    --37386825(+) GTCTCA/GTGGGG 2 -- ds50010--------
    rs1120307311,2
    C--37386845(+) ATGTCC/TGGGAA 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs7138291,2
    C,F,A,H--37386920(+) TCACAT/CAGGGC 2 -- ds500125Minor allele frequency- C:0.20NA EA NS WA CSA 2764
    rs1850209301,2
    --37386964(+) CAGAGC/TCATGC 2 -- ds50010--------
    rs1131359651,2
    F--37386994(+) CTGGGA/GTAATG 2 -- ds50013Minor allele frequency- G:0.03CSA WA 122
    rs1890763071,2
    --37386999(+) ATAATA/GGATGA 2 -- ds50010--------
    rs286332621,2
    C--37387029(+) TGTGTG/TCAGGA 2 -- ds50012Minor allele frequency- T:0.06WA 120

    HapMap Linkage Disequilibrium report for TEX33 (37387160 - 37403882 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX33: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX33
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX33 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of testis 14-3-3 binding proteins by t andem affinity purification. (PubMed id 22332119)1, 3 Puri P....Vijayaraghavan S. (2011)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339669 HGNC: 28568 AceView: MGC35206 Ensembl:ENSG00000185264 euGenes: HUgn339669
    ECgene: TEX33 H-InvDB: TEX33

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX33 gene:
    Search GeneIP for patents involving TEX33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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