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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX30 Gene

protein-coding   GIFtS: 39
GCID: GC13M103419

Testis Expressed 30

(Previous name: chromosome 13 open reading frame 27)
(Previous symbol: C13orf27)
  Search for TEX30
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 301 2
C13orf271 2 3
Chromosome 13 Open Reading Frame 271
Testis-Expressed Sequence 30 Protein2

External Ids:    HGNC: 251881   Entrez Gene: 930812   Ensembl: ENSG000001512877   UniProtKB: Q5JUR73   

Export aliases for TEX30 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX30 Gene: 
TEX30 (testis expressed 30) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX30
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX30 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.1   Ensembl cytogenetic band:  13q33.1   HGNC cytogenetic band: 13q33.1

TEX30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX30 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M103419:  view genomic region     (about GC identifiers)

Start:
103,418,340 bp from pter      End:
103,426,161 bp from pter
Size:
7,822 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX30_HUMAN, Q5JUR7 (See protein sequence)
Recommended Name: Testis-expressed sequence 30 protein  
Size: 227 amino acids; 25585 Da
Sequence caution: Sequence=AAH15148.2; Type=Erroneous initiation; Sequence=CAI14521.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q96KZ8

Explore the universe of human proteins at neXtProt for TEX30: NX_Q5JUR7

Explore proteomics data for TEX30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JUR7

  • TEX30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX30 Protein Expression
    REFSEQ proteins: NP_620134.3  
    ENSEMBL proteins: 
     ENSP00000365195   ENSP00000365187   ENSP00000365190   ENSP00000365189   ENSP00000365200  
     ENSP00000365197  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026555 NSL3/Tex30

    Graphical View of Domain Structure for InterPro Entry Q5JUR7

    ProtoNet protein and cluster: Q5JUR7


    TEX30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
         
    TEX30 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TEX30:
     Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX30 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX30

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX30

    Search CenterWatch for drugs/clinical trials and news about TEX30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX30 gene: 
    NM_138779.3  

    Unigene Cluster for TEX30:

    Testis expressed 30
    Hs.398111  [show with all ESTs]
    Unigene Representative Sequence: BG029987
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376027 ENST00000376019(uc001vpn.3) ENST00000376022 ENST00000376021
    ENST00000376032(uc001vpo.3) ENST00000376029 ENST00000487260
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX30

    Additional mRNA sequence: 

    AK314995.1 BC015148.2 

    9 DOTS entries:

    DT.92430473  DT.99972047  DT.75102522  DT.451869  DT.95279443  DT.95279444  DT.120786965  DT.100732502 
    DT.99942666 

    24/139 AceView cDNA sequences (see all 139):

    AI088947 AV717658 CA950214 BQ681567 AA766643 AI638515 AA888971 AA259116 
    CD515407 AF070559 BE881471 NM_138779 AA401719 BI260044 AA687335 AI217881 
    BI831687 BE748148 AV659878 BC015148 AI192387 CR611685 AI023819 BX953735 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TEX30 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                          -                                                         
    SP2:                          -                             -                           
    SP3:                          -     -                                                   
    SP4:                          -     -                       -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TEX30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX30 expression in normal human tissues (normalized intensities)      TEX30 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATCTTGAG
    TEX30 Expression
    About this image


    TEX30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium

    See TEX30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX30

    SOURCE GeneReport for Unigene cluster: Hs.398111
        SABiosciences Custom PCR Arrays for TEX30
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TEX30 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex301 , 5 RIKEN cDNA 1700029F09 gene5
    testis expressed 301
    94.07(n)1
    96(a)1
      1 (23.54 cM)5
    756231  NM_029368.11  NP_083644.11 
     440866135 
    chicken
    (Gallus gallus)
    Aves TEX301 testis expressed 30 73.27(n)
    68.47(a)
      418767  XM_416964.3  XP_416964.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEX306
    testis expressed 30
    58(a)
    1 ↔ 1
    3(101003408-101013233)
    zebrafish
    (Danio rerio)
    Actinopterygii tex301 testis expressed 30 54.11(n)
    46.51(a)
      567483  XM_690780.4  XP_695872.3 


    ENSEMBL Gene Tree for TEX30 (if available)
    TreeFam Gene Tree for TEX30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in TEX30 are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927694351,2
    --84020441(+) ATATAA/CACACA 1 -- us2k10--------
    rs1454688591,2
    --103417983(+) AGAGAC/GAGGGT 1 -- int10--------
    rs1476578691,2
    C--103418148(+) CCCAGA/CCTCAC 1 -- int10--------
    rs1930354161,2
    --103418411(+) GATAAC/TGCTGC 1 -- int10--------
    rs1159229651,2
    F--103418493(+) TTTTTT/CCAAAA 1 -- ut311Minor allele frequency- C:0.06WA 118
    rs1406953311,2
    C--103418557(+) CATCAC/TCTTTA 1 -- ut310--------
    rs79631,2
    C,F,O,H--103418566(-) ACAGTT/CGTATA 1 -- ut31 ese316Minor allele frequency- C:0.06MN NA NS EA 1698
    rs1848287551,2
    --103418574(+) TGTAAC/TAGTGC 1 -- ut310--------
    rs1880745951,2
    --103418588(+) CAAAAG/TACATT 1 -- ut310--------
    rs80541,2
    C,F,A,H--103418728(-) TTGAGT/CACACA 1 -- ut31 ese328Minor allele frequency- C:0.35MN NA NS EA WA CSA EU 4145

    HapMap Linkage Disequilibrium report for TEX30 (103418340 - 103426161 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX30: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX30
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX30 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93081 HGNC: 25188 AceView: LOC93081 Ensembl:ENSG00000151287 euGenes: HUgn93081
    ECgene: TEX30 H-InvDB: TEX30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX30 gene:
    Search GeneIP for patents involving TEX30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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