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TEX30 Gene

protein-coding   GIFtS: 38
GCID: GC13M103419

Testis Expressed 30

(Previous name: chromosome 13 open reading frame 27)
(Previous symbol: C13orf27)
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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 301 2
C13orf271 2 3
Chromosome 13 Open Reading Frame 271
Testis-Expressed Sequence 30 Protein2

External Ids:    HGNC: 251881   Entrez Gene: 930812   Ensembl: ENSG000001512877   UniProtKB: Q5JUR73   

Export aliases for TEX30 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX30 Gene:
TEX30 (testis expressed 30) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TEX30
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX30 promoter sequence
   Search Chromatin IP Primers for TEX30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.1   Ensembl cytogenetic band:  13q33.1   HGNC cytogenetic band: 13q33.1

TEX30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX30 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M103419:  view genomic region     (about GC identifiers)

Start:
103,418,340 bp from pter      End:
103,426,161 bp from pter
Size:
7,822 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TEX30_HUMAN, Q5JUR7 (See protein sequence)
Recommended Name: Testis-expressed sequence 30 protein  
Size: 227 amino acids; 25585 Da
Sequence caution: Sequence=AAH15148.2; Type=Erroneous initiation; Sequence=CAI14521.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q96KZ8

Explore the universe of human proteins at neXtProt for TEX30: NX_Q5JUR7

Explore proteomics data for TEX30 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273704.1  NP_001273705.1  NP_620134.3  

    ENSEMBL proteins: 
     ENSP00000365195   ENSP00000365187   ENSP00000365190   ENSP00000365189   ENSP00000365200  
     ENSP00000365197  

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    antibodies-online proteins for TEX30 (4 products) 

     
    antibodies-online peptides for TEX30

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026555 NSL3/Tex30

    Graphical View of Domain Structure for InterPro Entry Q5JUR7

    ProtoNet protein and cluster: Q5JUR7


    Find genes that share domains with TEX30           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with TEX30           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TEX30:
     Increased cell number in G1, a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TEX30

    miRNA
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    miRTarBase miRNAs that target TEX30:
    hsa-mir-215-5p (MIRT024557), hsa-mir-26b-5p (MIRT029390), hsa-mir-192-5p (MIRT026477), hsa-mir-373-3p (MIRT003943)

    Block miRNA regulation of human, mouse, rat TEX30 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat TEX30

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    Sino Biological Human cDNA Clone for TEX30
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX30

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX30
    Interactions:

        Search GeneGlobe Interaction Network for TEX30

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX30



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX30 gene (3 alternative transcripts): 
    NM_001286775.1  NM_001286776.1  NM_138779.4  

    Unigene Cluster for TEX30:

    Testis expressed 30
    Hs.398111  [show with all ESTs]
    Unigene Representative Sequence: BG029987
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376027 ENST00000376019(uc001vpn.3) ENST00000376022 ENST00000376021
    ENST00000376032(uc001vpo.3) ENST00000376029 ENST00000487260
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TEX30
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat TEX30

    Additional mRNA sequence: 

    AK314995.1 BC015148.2 

    9 DOTS entries:

    DT.92430473  DT.99972047  DT.75102522  DT.451869  DT.95279443  DT.95279444  DT.120786965  DT.100732502 
    DT.99942666 

    Selected AceView cDNA sequences (see all 139):

    BC015148 BI260044 BQ681567 AI088947 AA888971 BM563222 BX953735 BE881471 
    BC048011 AI192387 AA401719 BF590581 AI032507 CD515407 N66174 AA766643 
    AA259116 CA950214 AA644562 AA687335 AI217881 AV717658 BE748148 AI638515 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TEX30 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                          -                                                         
    SP2:                          -                             -                           
    SP3:                          -     -                                                   
    SP4:                          -     -                       -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TEX30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATCTTGAG
    TEX30 Expression
    About this image


    TEX30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
    TEX30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.398111
        Custom PCR Arrays for TEX30
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TEX30 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex301 , 5 RIKEN cDNA 1700029F09 gene5
    testis expressed 301
    94.07(n)1
    96(a)1
      1 (23.54 cM)5
    756231  NM_029368.11  NP_083644.11 
     440866135 
    chicken
    (Gallus gallus)
    Aves C1H13ORF271 chromosome 1 open reading frame, human C13orf27 73.12(n)
    68.47(a)
      418767  NM_001277762.1  NP_001264691.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEX306
    testis expressed 30
    58(a)
    1 ↔ 1
    3(101003408-101013233)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tex301 testis expressed 30 67.04(n)
    60.34(a)
      549282  NM_001016528.2  NP_001016528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tex301 testis expressed 30 54.34(n)
    46.92(a)
      567483  XM_690780.5  XP_695872.3 


    ENSEMBL Gene Tree for TEX30 (if available)
    TreeFam Gene Tree for TEX30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX30 (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927694351,2
    --84020441(+) ATATAA/CACACA 1 -- us2k10--------
    rs1454688591,2
    --103417983(+) AGAGAC/GAGGGT 1 -- int10--------
    rs1476578691,2
    C--103418148(+) CCCAGA/CCTCAC 1 -- int10--------
    rs1930354161,2
    --103418411(+) GATAAC/TGCTGC 1 -- int10--------
    rs1159229651,2
    F--103418493(+) TTTTTT/CCAAAA 1 -- ut311Minor allele frequency- C:0.06WA 118
    rs1406953311,2
    C--103418557(+) CATCAC/TCTTTA 1 -- ut310--------
    rs79631,2
    C,F,O,H--103418566(-) ACAGTT/CGTATA 1 -- ut31 ese316Minor allele frequency- C:0.06MN NA NS EA 1698
    rs1848287551,2
    --103418574(+) TGTAAC/TAGTGC 1 -- ut310--------
    rs1880745951,2
    --103418588(+) CAAAAG/TACATT 1 -- ut310--------
    rs80541,2
    C,F,A,H--103418728(-) TTGAGT/CACACA 1 -- ut31 ese328Minor allele frequency- C:0.35MN NA NS EA WA CSA EU 4145

    HapMap Linkage Disequilibrium report for TEX30 (103418340 - 103426161 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TEX30: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX30
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX30 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEX30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93081 HGNC: 25188 AceView: LOC93081 Ensembl:ENSG00000151287 euGenes: HUgn93081
    ECgene: TEX30 H-InvDB: TEX30

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX30 gene:
    Search GeneIP for patents involving TEX30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat TEX30 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TEX30
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX30 Predesigned siRNA for gene silencing in human, mouse, rat TEX30
     QuantiFast Probe-based Assays in human, mouse, rat TEX30 QuantiTect SYBR Green Assays in human, mouse, rat TEX30
     Custom PCR Arrays for TEX30 Search Chromatin IP Primers for TEX30
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TEX30 Search GeneGlobe Interaction Network for TEX30
     Search Regulatory tfbs for TEX30
     GenScript Custom Purified and Recombinant Proteins Services for TEX30 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TEX30
     GenScript Custom Assay Services for TEX30 GenScript Custom overexpressing Cell Line Services for TEX30
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TEX30
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TEX30
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TEX30 antibodies
     TEX30 proteins
     TEX30 lysates
     Search for Antibodies for TEX30 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TEX30
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TEX30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX30
     SwitchGear 3'UTR luciferase reporter plasmids for TEX30
     SwitchGear Promoter luciferase reporter plasmids for TEX30
     ThermoFisher Antibodies for TEX30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX30
     Browse compounds at ApexBio
     Search Addgene for plasmids for TEX30
      Search eBioscience for proteins for TEX30
      Search eBioscience for elisas for TEX30
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TEX30
     antibodies-online antibodies for TEX30
     antibodies-online kits for TEX30
     antibodies-online peptides for TEX30
     antibodies-online proteins for TEX30 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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