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TEX28 Gene

protein-coding   GIFtS: 45
GCID: GC0XM153498

Testis Expressed 28

(Previous name: chromosome X open reading frame 2)
(Previous symbol: CXorf2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 281 2     TEX28P22
CXorf21 2 3     fTEX2
Chromosome X Open Reading Frame 21     Testis-Specific Protein TEX282
TEX28P12     

External Ids:    HGNC: 25631   Entrez Gene: 15272   Ensembl: ENSG000001852547   OMIM: 3000925   UniProtKB: O154823   

Export aliases for TEX28 gene to outside databases

Previous GC identifers: GC0XM153154 GC0XM142075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX28 Gene:
TEX28 (testis expressed 28) is a protein-coding gene. Diseases associated with TEX28 include color vision deficiency, and endometritis. An important paralog of this gene is TEX28P1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TEX28 gene promoter:
         HFH-3   AhR   AML1a   Arnt   FOXI1   MZF-1   FOXJ2 (long isoform)   Cart-1   Msx-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX28 promoter sequence
   Search Chromatin IP Primers for TEX28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

TEX28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX28 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153498:  view genomic region     (about GC identifiers)

Start:
153,498,930 bp from pter      End:
153,523,796 bp from pter
Size:
24,867 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482 (See protein sequence)
Recommended Name: Testis-specific protein TEX28  
Size: 410 amino acids; 46131 Da
Secondary accessions: B1B1E8 D3DWW5

Explore the universe of human proteins at neXtProt for TEX28: NX_O15482

Explore proteomics data for TEX28 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192130.1  NP_001577.1  

    ENSEMBL proteins: 
     ENSP00000358942   ENSP00000355323   ENSP00000406419  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017387 Testis-specific_TEX28
     IPR019394 Predicted_TM_coiled-coil_2

    Graphical View of Domain Structure for InterPro Entry O15482

    ProtoNet protein and cluster: O15482

    UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482
    Similarity: Belongs to the TEX28 family


    TEX28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TEX28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TEX28:
     Increased number of cells in m 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEX28_HUMAN, O15482: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TEX28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX28
    Interactions:

        Search GeneGlobe Interaction Network for TEX28

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TEX28 (O154822, 3 ENSP000003553234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8Q129292, 3, ENSP000002811724MINT-68345 I2D: score=5 STRING: ENSP00000281172
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0008150biological_process ND--

    TEX28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX28



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEX28 gene (2 alternative transcripts): 
    NM_001205201.1  NM_001586.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369926(uc004fkf.3 uc010nut.1) ENST00000361930(uc004fke.3)
    ENST00000428625
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX28
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TEX28
      QuantiFast Probe-based Assays in human, mouse, rat TEX28

    10 AceView cDNA sequences:

    NM_001586 BC026183 BX280786 BI826964 BI825689 U93720 BM728212 BI459565 
    BM681381 AW629285 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATGCTGA
    TEX28 Expression
    About this image

    TEX28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX28 Protein Expression

    UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482
    Tissue specificity: Testis specific

        Custom PCR Arrays for TEX28
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    QuantiFast Probe-based Assays in human, mouse, rat TEX28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEX28 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex281 , 5 testis expressed 281, 5 72.99(n)1
    59.61(a)1
      X (37.79 cM)5
    3853801  NM_001126488.21  NP_001119960.11 
     741509445 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    2(88670512-88675481)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG10216
    --
    13(a)
    1 → many
    3R(2214884-2231613)
    worm
    (Caenorhabditis elegans)
    Secernentea C15H9.46
    Protein C15H9.4 (C15H9.4) mRNA, complete cds
    12(a)
    1 → many
    X(6101215-6105462) WBGene00015800


    ENSEMBL Gene Tree for TEX28 (if available)
    TreeFam Gene Tree for TEX28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEX28 gene
    TEX28P12  TEX28P22  TMCC12  TMCC32  TMCC22  
    5 SIMAP similar genes for TEX28 using alignment to 2 protein entries:     TEX28_HUMAN (see all proteins):
    TEX28P1    TEX28P2    TMCC3    TMCC1    TMCC2

    TEX28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX28 (see all 70)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436399721,2
    C--153502576(+) AGTCTA/CTTCAG 2 -- int10--------
    rs2021164951,2
    C--153502665(+) CAGCCA/GCGCTC 2 -- int10--------
    rs112749731,2
    --153504543(+) AGTTC-/TTGTG 
    CCTTCAAG
    TTAAC
    2 -- int10--------
    rs2020848011,2
    C--153504543(+) AGTTC-/TTGTG 
    CCTTCAAG
    TTAAC
    2 -- int10--------
    rs679213861,2
    --153504545(+) TTCTT-/GTGCC 
    TTCAAGTT
    AACAC
    2 -- int10--------
    rs1901205601,2
    --153505034(+) GCAACC/TACCAT 2 -- int10--------
    rs605817501,2
    C--153505208(+) GGTGGC/TGCGCG 2 -- int10--------
    rs59872251,2
    C,F--153505210(+) TGGTGC/GGCGCC 2 -- int13Minor allele frequency- G:0.17NA WA 6
    rs1126035281,2
    C,F--153505232(+) CTACTG/CGGGAG 2 -- int11Minor allele frequency- C:0.50WA 2
    rs59872261,2
    C,F,A,H--153505295(+) agatcA/Ccgcca 2 -- int15Minor allele frequency- C:0.33NA WA CSA 12

    HapMap Linkage Disequilibrium report for TEX28 (153498930 - 153523796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TEX28:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7161CNV Loss18451855
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    esv27518CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TEX28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300092    OMIM disorders: --

    7 diseases for TEX28:    
    About MalaCards
    color vision deficiency    endometritis    blue cone monochromacy    achromatopsia
    color blindness    myopia    blindness

    3 diseases from the University of Copenhagen DISEASES database for TEX28:
    Blue cone monochromacy     Color blindness     Achromatopsia

    TEX28 for disorders           About GeneDecksing


    Export disorders for TEX28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX28 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEX28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene within the tandem array of red and green color pigment genes. (PubMed id 9268643)1, 2, 3 Hanna M.C.... Kirkness E.F. (Genomics 1997)
    2. An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays. (PubMed id 15378397)1, 3, 9 Ueyama H....Yamade S. (J. Hum. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. (PubMed id 19098318)1, 9 Metlapally R....Young T.L. (amp 2009)
    5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (Genome Res. 2007)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1527 HGNC: 2563 AceView: CXorf2 Ensembl:ENSG00000185254 euGenes: HUgn1527
    ECgene: TEX28 H-InvDB: TEX28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX28 gene:
    Search GeneIP for patents involving TEX28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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