Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEX261 Gene

Aliases for TEX261 Gene

  • Testis Expressed 261 2 3 5
  • Testis Expressed Sequence 261 2 3
  • Protein TEX261 3
  • TEG-261 3

External Ids for TEX261 Gene

Previous GeneCards Identifiers for TEX261 Gene

  • GC02M071126
  • GC02M071187
  • GC02M071124
  • GC02M071174
  • GC02M070949
  • GC02M071215
  • GC02M071216
  • GC02M071217
  • GC02M071218
  • GC02M071221

Summaries for TEX261 Gene

GeneCards Summary for TEX261 Gene

TEX261 (Testis Expressed 261) is a Protein Coding gene. GO annotations related to this gene include COPII adaptor activity. An important paralog of this gene is ENSG00000258881.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX261 Gene

Genomics for TEX261 Gene

Regulatory Elements for TEX261 Gene

Enhancers for TEX261 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TEX261 on UCSC Golden Path with GeneCards custom track

Promoters for TEX261 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TEX261 Gene

Chromosome:
2
Start:
70,985,938 bp from pter
End:
70,994,945 bp from pter
Size:
9,008 bases
Orientation:
Minus strand

Genomic View for TEX261 Gene

Genes around TEX261 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX261 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX261 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX261 Gene

Proteins for TEX261 Gene

  • Protein details for TEX261 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWH6-TX261_HUMAN
    Recommended name:
    Protein TEX261
    Protein Accession:
    Q6UWH6
    Secondary Accessions:
    • A1A587
    • D6W5G9
    • Q8WUJ5

    Protein attributes for TEX261 Gene

    Size:
    196 amino acids
    Molecular mass:
    22538 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX261 Gene

Post-translational modifications for TEX261 Gene

No Post-translational modifications

Other Protein References for TEX261 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX261 Gene

Domains & Families for TEX261 Gene

Protein Domains for TEX261 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX261 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWH6

UniProtKB/Swiss-Prot:

TX261_HUMAN :
  • Belongs to the SVP26 family.
Family:
  • Belongs to the SVP26 family.
genes like me logo Genes that share domains with TEX261: view

No data available for Gene Families for TEX261 Gene

Function for TEX261 Gene

Gene Ontology (GO) - Molecular Function for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097020 COPII adaptor activity IBA --
genes like me logo Genes that share ontologies with TEX261: view
genes like me logo Genes that share phenotypes with TEX261: view

Animal Model Products

CRISPR Products

miRNA for TEX261 Gene

miRTarBase miRNAs that target TEX261

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEX261 Gene

Localization for TEX261 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX261 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX261 Gene COMPARTMENTS Subcellular localization image for TEX261 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030134 ER to Golgi transport vesicle IBA --
GO:0030173 integral component of Golgi membrane IBA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with TEX261: view

Pathways & Interactions for TEX261 Gene

SuperPathways for TEX261 Gene

No Data Available

Interacting Proteins for TEX261 Gene

Gene Ontology (GO) - Biological Process for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with TEX261: view

No data available for Pathways by source and SIGNOR curated interactions for TEX261 Gene

Drugs & Compounds for TEX261 Gene

No Compound Related Data Available

Transcripts for TEX261 Gene

Unigene Clusters for TEX261 Gene

Testis expressed 261:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX261 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TEX261 Gene

GeneLoc Exon Structure for
TEX261
ECgene alternative splicing isoforms for
TEX261

Expression for TEX261 Gene

mRNA expression in normal human tissues for TEX261 Gene

Protein differential expression in normal tissues from HIPED for TEX261 Gene

This gene is overexpressed in Ovary (36.0), Prostate (24.0), and Liver (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX261 Gene



Protein tissue co-expression partners for TEX261 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX261 Gene:

TEX261

SOURCE GeneReport for Unigene cluster for TEX261 Gene:

Hs.516087
genes like me logo Genes that share expression patterns with TEX261: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TEX261 Gene

Orthologs for TEX261 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEX261 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEX261 34
  • 93.45 (n)
  • 99.42 (a)
TEX261 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TEX261 34
  • 92.95 (n)
  • 97.71 (a)
-- 35
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tex261 34
  • 91.5 (n)
  • 99.49 (a)
Tex261 16
Tex261 35
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TEX261 34
  • 99.83 (n)
  • 100 (a)
TEX261 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex261 34
  • 91.5 (n)
  • 99.49 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2834 34
tex261 34
  • 77.38 (n)
  • 89.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia tex261-prov 34
zebrafish
(Danio rerio)
Actinopterygii tex261 34
  • 76.19 (n)
  • 85.71 (a)
wufb72a06 34
tex261 35
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011456 34
  • 54.39 (n)
  • 50.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3500 34
  • 56.89 (n)
  • 51.83 (a)
CG3500 35
  • 49 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR127W 34
  • 49.81 (n)
  • 42.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09295g 34
  • 48.25 (n)
  • 42.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SVP26 34
  • 49.8 (n)
  • 44.64 (a)
SVP26 35
  • 34 (a)
OneToMany
SVP26 37
bread mold
(Neurospora crassa)
Ascomycetes NCU00778 34
  • 53.76 (n)
  • 43.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToMany
Species where no ortholog for TEX261 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX261 Gene

ENSEMBL:
Gene Tree for TEX261 (if available)
TreeFam:
Gene Tree for TEX261 (if available)

Paralogs for TEX261 Gene

Paralogs for TEX261 Gene

genes like me logo Genes that share paralogs with TEX261: view

Variants for TEX261 Gene

Sequence variations from dbSNP and Humsavar for TEX261 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2276684 -- 70,993,663(-) TCCTC(A/C)CTCTT intron-variant
rs2286979 -- 70,988,979(+) GCAAA(C/T)GGAAT downstream-variant-500B, reference, synonymous-codon
rs2286980 -- 70,989,116(+) GCCAC(A/C)CCTGA intron-variant, utr-variant-3-prime
rs2286981 -- 70,989,164(+) CCACC(A/C)TCAGA intron-variant, utr-variant-3-prime
rs7583998 -- 70,990,408(+) ATACC(A/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX261 Gene

Variant ID Type Subtype PubMed ID
esv2666405 CNV deletion 23128226
esv27910 CNV gain 19812545
esv3591215 CNV loss 21293372
nsv1013232 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv517881 CNV loss 19592680

Variation tolerance for TEX261 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX261 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX261

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX261 Gene

Disorders for TEX261 Gene

Relevant External Links for TEX261

Genetic Association Database (GAD)
TEX261
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX261

No disorders were found for TEX261 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX261 Gene

Publications for TEX261 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  3. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. (PMID: 9464256) LA^pez-FernA!ndez L.A. … del Mazo J. (Biochem. Biophys. Res. Commun. 1998) 2 3 65
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65

Products for TEX261 Gene

Sources for TEX261 Gene

Content
Loading form....