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Aliases for TEX2 Gene

Aliases for TEX2 Gene

  • Testis Expressed 2 2 3 5
  • Transmembrane Protein 96 2 3 4
  • Testis Expressed Sequence 2 2 3
  • TMEM96 3 4
  • Testis-Expressed Sequence 2 Protein 3
  • Testis-Expressed Protein 2 3
  • KIAA1738 4
  • HT008 3

External Ids for TEX2 Gene

Previous GeneCards Identifiers for TEX2 Gene

  • GC17M059579
  • GC17M062224
  • GC17M057594

Summaries for TEX2 Gene

GeneCards Summary for TEX2 Gene

TEX2 (Testis Expressed 2) is a Protein Coding gene.

Additional gene information for TEX2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX2 Gene

Genomics for TEX2 Gene

Regulatory Elements for TEX2 Gene

Enhancers for TEX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H064213 1.6 Ensembl ENCODE dbSUPER 19.3 +47.1 47141 5.4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 CEP95 DDX42 POLG2 SLC16A6P1 TEX2 ENSG00000265982 SMARCD2 ENSG00000265912 FTSJ3 PLEKHM1P1
GH17H064239 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +22.3 22349 2.7 BCOR PKNOX1 ZFHX2 POLR2A EGR1 SCRT2 FOS ZNF600 RCOR1 NFE2 TEX2 SNORA50C
GH17H064229 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +31.9 31943 3.3 TAL1 TCF12 CTBP1 GATA2 POLR2A NCOR1 NFE2 ATF7 TRIM24 CREM TEX2 CEP95 POLG2 SLC16A6P1 ENSG00000265982 DDX42 PLEKHM1P1 DDX5 FTSJ3 PRR29
GH17H064201 1.3 Ensembl ENCODE dbSUPER 18.8 +60.5 60500 2.2 MXI1 PKNOX1 SAP130 SIN3A RAD21 YY1 TEAD3 FOSL1 HIC1 GATA3 TEX2 SNORA50C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEX2 on UCSC Golden Path with GeneCards custom track

Promoters for TEX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096923 223 1801 HDGF ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 ZNF207 SP3

Genomic Locations for TEX2 Gene

Genomic Locations for TEX2 Gene
116,097 bases
Minus strand

Genomic View for TEX2 Gene

Genes around TEX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX2 Gene

Proteins for TEX2 Gene

  • Protein details for TEX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-expressed protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6AHZ5
    • Q8N3L0
    • Q9C0C5

    Protein attributes for TEX2 Gene

    1127 amino acids
    Molecular mass:
    125303 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TEX2 Gene


neXtProt entry for TEX2 Gene

Post-translational modifications for TEX2 Gene

  • Glycosylation at Asn330
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TEX2 Gene

Domains & Families for TEX2 Gene

Gene Families for TEX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TEX2 Gene


Suggested Antigen Peptide Sequences for TEX2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEX2: view

No data available for UniProtKB/Swiss-Prot for TEX2 Gene

Function for TEX2 Gene

Phenotypes From GWAS Catalog for TEX2 Gene

Gene Ontology (GO) - Molecular Function for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IBA --
genes like me logo Genes that share ontologies with TEX2: view
genes like me logo Genes that share phenotypes with TEX2: view

Animal Model Products

CRISPR Products

miRNA for TEX2 Gene

miRTarBase miRNAs that target TEX2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEX2 Gene

Localization for TEX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX2 gene
Compartment Confidence
plasma membrane 3
nucleus 3
endoplasmic reticulum 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 16449791
genes like me logo Genes that share ontologies with TEX2: view

Pathways & Interactions for TEX2 Gene

No Data Available

Interacting Proteins for TEX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8IWB9-TEX2_HUMAN ENSP00000258991 for TEX2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process NAS 16449791
GO:0007165 signal transduction NAS 16449791
genes like me logo Genes that share ontologies with TEX2: view

No data available for Pathways by source and SIGNOR curated interactions for TEX2 Gene

Drugs & Compounds for TEX2 Gene

No Compound Related Data Available

Transcripts for TEX2 Gene

Unigene Clusters for TEX2 Gene

Testis expressed 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP5: - -
SP6: -
SP7: - - - -
SP8: - - -

Relevant External Links for TEX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX2 Gene

Protein differential expression in normal tissues from HIPED for TEX2 Gene

This gene is overexpressed in Pancreas (19.0), Plasma (12.5), Breast (8.9), and Lung (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TEX2 Gene

Protein tissue co-expression partners for TEX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX2 Gene:


SOURCE GeneReport for Unigene cluster for TEX2 Gene:


Evidence on tissue expression from TISSUES for TEX2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with TEX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX2 Gene

Orthologs for TEX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TEX2 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia TEX2 33 34
  • 91.47 (n)
(Bos Taurus)
Mammalia TEX2 33 34
  • 89.12 (n)
(Rattus norvegicus)
Mammalia Tex2 33
  • 87.62 (n)
(Mus musculus)
Mammalia Tex2 33 16 34
  • 87.28 (n)
(Monodelphis domestica)
Mammalia TEX2 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
-- 34
  • 73 (a)
(Gallus gallus)
Aves TEX2 33 34
  • 74.11 (n)
(Anolis carolinensis)
Reptilia TEX2 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tex2.2 33
  • 67.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24580 33
(Danio rerio)
Actinopterygii tex2 33 34
  • 63.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43783 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea F55C12.5 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NVJ2 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7607 34
  • 40 (a)
Species where no ortholog for TEX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEX2 Gene

Gene Tree for TEX2 (if available)
Gene Tree for TEX2 (if available)

Paralogs for TEX2 Gene

(1) SIMAP similar genes for TEX2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEX2: view

No data available for Paralogs for TEX2 Gene

Variants for TEX2 Gene

Sequence variations from dbSNP and Humsavar for TEX2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000018271 -- 64,183,325(+) GCTCA(C/T)ATGGT intron-variant
rs1000030756 -- 64,239,461(+) TGGAA(A/C)ATACA intron-variant
rs1000034265 -- 64,147,515(+) GTGCA(A/G)CATGG utr-variant-3-prime
rs1000035027 -- 64,177,447(+) TTCCT(C/T)CTCAG reference, missense
rs1000071050 -- 64,231,524(+) GTCTC(C/T)GGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEX2 Gene

Variant ID Type Subtype PubMed ID
nsv833513 CNV loss 17160897
nsv833512 CNV gain+loss 17160897
nsv524852 CNV gain 19592680
nsv511058 OTHER complex 20534489
nsv509666 CNV insertion 20534489
nsv483108 CNV loss 15286789
nsv2117 CNV deletion 18451855
nsv1123138 CNV deletion 24896259
nsv1066968 CNV gain 25217958
esv3641026 CNV loss 21293372
esv3554643 CNV deletion 23714750
esv2716103 CNV deletion 23290073

Variation tolerance for TEX2 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX2 Gene

Disorders for TEX2 Gene

Relevant External Links for TEX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TEX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX2 Gene

Publications for TEX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for TEX2 Gene

Sources for TEX2 Gene

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