TEX2 Gene
protein-coding GIFtS : 47
GCID: GC17 M062224
testis expressed 2 (Previous name: testis expressed sequence 2 )
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Aliasesfor TEX2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Testis Expressed 2 1 2 KIAA17381 3 TMEM961 2 3 Transmembrane Protein 962 3 HT0081 2 Testis-Expressed Sequence 2 Protein2 Testis Expressed Sequence 21 2
Export aliases for TEX2 gene to outside databases Previous GC identifers: GC17M059579 GC17M057594
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Summariesfor TEX2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TEX2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TEX2 gene promoter: SRF AML1a ATF-2 SRF (504 AA) Ik-3 Meis-1b HNF-4alpha1 CP2 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TEX2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TEX2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3 TEX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M062224: view genomic region
(about GC identifiers )
Start:
62,224,587 bp from pter
End:
62,340,661 bp from pter
Size:
116,075 bases
Orientation:
minus strand
1 alternative location : Chr 17-,PATCHES 62,249,313-62,300,032
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Proteinsfor TEX2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TEX2_HUMAN, Q8IWB9 (See
protein sequence )Recommended Name: Testis-expressed sequence 2 protein Size : 1127 amino acids; 125303 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q6AHZ5 Q8N3L0 Q9C0C5Alternative splicing : 2 isoforms : Q8IWB9-1 Q8IWB9-2 Explore the universe of human proteins at neXtProt for TEX2: NX_Q8IWB9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IWB9 TEX2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060939.3 ENSEMBL proteins: ENSP00000258991 ENSP00000462665 ENSP00000463001 ENSP00000462230 ENSP00000463286 ENSP00000462210 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
TEX2 for ontologies About GeneDecksing TEX2 Antibody Products: Assay Products for TEX2:
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Protein
Domains / Familiesfor TEX2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TEX2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IWB9 ProtoNet protein and cluster: Q8IWB9
1 Blocks protein family : IPB001849 Pleckstrin-like
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Functionfor TEX2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TEX2 (NM_001586 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEX2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND -- GO:0005543 phospholipid binding
IEA --
TEX2 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for TEX2 :
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Pathways & Interactionsfor TEX2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TEX2 (Q8IWB9 3 ENSP00000258991 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
TEX2 for ontologies About GeneDecksing
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Drugs & Compoundsfor TEX2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TEX2 Search CenterWatch for drugs/clinical trials and news about TEX2
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Transcriptsfor TEX2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TEX2 gene: NM_018469.3 Unigene Cluster for TEX2:
Testis expressed 2 Hs.175414 [show with all ESTs ] Unigene Representative Sequence: NM_018469 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000258991 (uc002jec.3 uc002jed.3 uc002jee.3 ) ENST00000584498 ENST00000583097 ENST00000584379 ENST00000583501 ENST00000581812 ENST00000577489 ENST00000583922 ENST00000583738 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TEX2 (NM_001586 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEX2
Additional cDNA sequence: AB051525.2 AF163260.1 AF220182.1 AK000369.1 AK000758.1 AK091156.1 AK091214.1 AK314316.1 AL832371.1 AL834251.2 BC008896.2 BC033661.1 BC036672.1 BC040521.1 BC040522.1 BC108279.1 CR627433.1
13 DOTS entries : DT.101983796 DT.100642490
DT.443652 DT.101983795 DT.120936386 DT.100790572 DT.120936358 DT.120936378 DT.91745923 DT.95369374 DT.100671564 DT.65286504 DT.75130843 24/203 AceView cDNA sequences (see all 203 ):
CK825147 BC036672 BE503661 AI356056 BU627866 BF593394 BG259874 AX746854 AI948940 CA433754 AW152376 AI194040 BE891890 AI797390 BC033661 AK091156 BM802832 BC040521 AI611009 AI656908 AA332498 AI458451 BI870491 CA390462 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TEX2 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b SP1 :                   -             -             SP2 :                               -             SP3 :                                           SP4 :                                           SP5 :       -   -                                  
ECgene alternative splicing isoforms for TEX2
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Expression for TEX2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TEX2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTGAACCCT
About this image TEX2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TEX2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TEX2 SOURCE GeneReport for Unigene cluster: Hs.175414 SABiosciences Custom PCR Arrays for TEX2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TEX2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TEX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TEX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TEX2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX2
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Orthologsfor TEX2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TEX2 gene from 9/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for TEX2 (if available)TreeFam Gene Tree for TEX2 (if available)
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Paralogsfor TEX2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TEX2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TEX2 (62224587 - 62340661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TEX2 1 CNV : 0210
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TEX2
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Disorders
/ Diseasesfor TEX2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor TEX2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TEX2 gene integrated from 9 sources : (articles sorted by number of sources associating them with TEX2) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970) 1 , 2 , 3 Nagase T.... Ohara O. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Diverse membrane-associated proteins contain a novel SMP domain. (PubMed id 16449791) 1 Lee I. and Hong W. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TEX2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TEX2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TEX2 gene
(According to HUGE )
About This Section
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Specialized Databases showing TEX2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TEX2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TEX2 gene: Search GeneIP for patents involving TEX2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TEX2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TEX2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TEX2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TEX2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TEX2 OriGene 3'-UTR Clone for TEX2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEX2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TEX2 OriGene Custom Protein Services for TEX2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEX2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TEX2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TEX2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TEX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TEX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TEX2
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TEX2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEX2
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