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TEX19 Gene

protein-coding   GIFtS: 39
GCID: GC17P080317

Testis Expressed 19

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 191 2
Testis-Expressed Sequence 19 Protein2

External Ids:    HGNC: 338021   Entrez Gene: 4006292   Ensembl: ENSG000001824597   OMIM: 6156475   UniProtKB: Q8NA773   

Export aliases for TEX19 gene to outside databases

Previous GC identifers: GC17P077911 GC17P075715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEX19 Gene:
TEX19 (testis expressed 19) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX19 gene promoter:
         Tal-1   Bach2   HNF-4alpha2   Tal-1beta   HNF-4alpha1   E47   MEF-2A   PPAR-alpha   aMEF-2   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

TEX19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX19 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080317:  view genomic region     (about GC identifiers)

Start:
80,317,123 bp from pter      End:
80,321,652 bp from pter
Size:
4,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: TEX19_HUMAN, Q8NA77 (See protein sequence)
Recommended Name: Testis-expressed sequence 19 protein  
Size: 164 amino acids; 18469 Da

Explore the universe of human proteins at neXtProt for TEX19: NX_Q8NA77

REFSEQ proteins: NP_997342.1  
ENSEMBL proteins: 
 ENSP00000331500  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8NA77


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TEX19_HUMAN, Q8NA77
Induction: Down-regulated by gonadotropin suppression sufficient to cause marked suppression of spermatogenesis
and additionally progestogen treatment

Phenotypes:
     1 GenomeRNAi human phenotype for TEX19:

 Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TEX19_HUMAN, Q8NA77: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with TEX19           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX19
Interactions:

    Search GeneGlobe Interaction Network for TEX19

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TEX19 (ENSP000003315004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBR2ENSP000003619904STRING: ENSP00000361990
UBR1ENSP000002906504STRING: ENSP00000290650
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TEX19 gene: 
NM_207459.3  

Unigene Cluster for TEX19:

Testis expressed 19
Hs.231897  [show with all ESTs]
Unigene Representative Sequence: BC050391
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000333437(uc002keq.3)
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Additional mRNA sequence: 

AK093086.1 BC016939.2 BC036191.1 BC050391.1 BC057820.1 BC126938.1 

3 DOTS entries:

DT.101980515  DT.120896431  DT.100698935 

Selected AceView cDNA sequences (see all 31):

CA426911 AI989999 BC050391 BC016939 BC036191 BI850590 CA310471 BM908179 
AK093086 AW573054 AL530720 AL559490 AL581097 BM827664 BC057820 BG177479 
AL520481 BG773422 BM455760 BX333071 BM817444 AX747912 NM_207459 CA416769 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEX19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCTGCAGAA
TEX19 Expression
About this image

TEX19 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.231897

UniProtKB/Swiss-Prot: TEX19_HUMAN, Q8NA77
Tissue specificity: Expressed in testis. Expressed in undifferentiated embryonic stem cells

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TEX19 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tex19.21 testis expressed gene 19.2 70.14(n)
59.03(a)
  70956  NM_027622.3  NP_081898.1 


ENSEMBL Gene Tree for TEX19 (if available)
TreeFam Gene Tree for TEX19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TEX19 (see all 224)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1911944271,2
C--80315174(+) TCCCTC/TCCCGG 1 -- us2k10--------
rs1811261511,2
C--80315186(+) CCCCTC/TCTGGC 1 -- us2k10--------
rs1395884151,2
--80315239(+) TCAGAA/GAAAAC 1 -- us2k10--------
rs728561671,2
C,F--80315339(+) CACCTG/CAGGGG 1 -- us2k11Minor allele frequency- C:0.02NA 120
rs1178503861,2
F--80315436(+) CCCCAC/GACCTG 1 -- us2k11Minor allele frequency- G:0.02NA 120
rs728561681,2
C,F--80315449(+) CCTATC/ACCAGG 1 -- us2k12Minor allele frequency- A:0.08NA EA 240
rs740016261,2
C,F--80315490(+) TGGCCC/TTGATC 1 -- us2k12Minor allele frequency- T:0.03WA 120
rs1860217221,2
--80315570(+) CTGCCA/GGGTGG 1 -- us2k10--------
rs1497135461,2
--80315657(+) GTCACC/TTTCTT 1 -- us2k10--------
rs1909281871,2
C--80315740(+) ACTTAC/TGTCTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TEX19 (80317123 - 80321652 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TEX19 (see all 26):    About this table    
Variant IDTypeSubtypePubMed ID
esv2716489CNV Deletion23290073
nsv821135CNV Deletion20802225
esv2162612CNV Deletion18987734
esv2716490CNV Deletion23290073
esv1367803CNV Insertion17803354
nsv909223CNV Loss21882294
nsv909220CNV Loss21882294
dgv3354n71CNV Loss21882294
dgv3357n71CNV Loss21882294
dgv3353n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615647    OMIM disorders: --


Find genes that share disorders with TEX19           About GenesLikeMe


Export disorders for TEX19 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TEX19 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TEX19)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. (PubMed id 18096721)1, 2 Kuntz S....Viville S. (Stem Cells 2008)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
  4. Molecular profiling of the human testis reveals stringent pathway- specific regulation of RNA expression following gonadotropin suppression and progestogen treatment. (PubMed id 18160741)2 Bayne R.A.... Anderson R.A. (J. Androl. 2008)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400629 HGNC: 33802 AceView: FLJ35767 Ensembl:ENSG00000182459 euGenes: HUgn400629
ECgene: TEX19 H-InvDB: TEX19

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TEX19 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TEX19 gene:
Search GeneIP for patents involving TEX19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TEX19 gene at Home site.
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