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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX19 Gene

protein-coding   GIFtS: 38
GCID: GC17P080317

Testis Expressed 19

  Search for TEX19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 191 2
Testis-Expressed Sequence 19 Protein2

External Ids:    HGNC: 338021   Entrez Gene: 4006292   Ensembl: ENSG000001824597   UniProtKB: Q8NA773   

Export aliases for TEX19 gene to outside databases

Previous GC identifers: GC17P077911 GC17P075715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX19 Gene: 
TEX19 (testis expressed 19) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX19 gene promoter:
         Tal-1   Bach2   HNF-4alpha2   Tal-1beta   HNF-4alpha1   E47   MEF-2A   PPAR-alpha   aMEF-2   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TEX19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

TEX19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX19 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080317:  view genomic region     (about GC identifiers)

Start:
80,317,123 bp from pter      End:
80,321,652 bp from pter
Size:
4,530 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX19_HUMAN, Q8NA77 (See protein sequence)
Recommended Name: Testis-expressed sequence 19 protein  
Size: 164 amino acids; 18469 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TEX19: NX_Q8NA77

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NA77

  • TEX19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_997342.1  
    ENSEMBL proteins: 
     ENSP00000331500  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TEX19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NA77


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEX19_HUMAN, Q8NA77
    Induction: Down-regulated by gonadotropin suppression sufficient to cause marked suppression of spermatogenesis
    and additionally progestogen treatment

    Phenotypes:
         1 GenomeRNAi human phenotype for TEX19:

     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX19

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX19

    Search CenterWatch for drugs/clinical trials and news about TEX19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX19 gene: 
    NM_207459.3  

    Unigene Cluster for TEX19:

    Testis expressed 19
    Hs.231897  [show with all ESTs]
    Unigene Representative Sequence: BC050391
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333437(uc002keq.3)
    miRNA
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    Additional mRNA sequence: 

    AK093086.1 BC016939.2 BC036191.1 BC050391.1 BC057820.1 BC126938.1 

    3 DOTS entries:

    DT.101980515  DT.120896431  DT.100698935 

    24/31 AceView cDNA sequences (see all 31):

    BC036191 BM908179 CA310471 BC016939 BC050391 CA426911 AI989999 BI850590 
    NM_207459 AK093086 AW573054 BM817444 AL520481 AL559490 BX333071 BG177479 
    AL581097 BM455760 AL530720 AX747912 BG773422 CA416769 BM827664 BC057820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGCAGAA
    TEX19 Expression
    About this image


    Genevestigator expression for TEX19

    SOURCE GeneReport for Unigene cluster: Hs.231897

    UniProtKB/Swiss-Prot: TEX19_HUMAN, Q8NA77
    Tissue specificity: Expressed in testis. Expressed in undifferentiated embryonic stem cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for TEX19 (if available)
    TreeFam Gene Tree for TEX19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 SNPs in TEX19 are shown (see all 224)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911944271,2
    C--80315174(+) TCCCTC/TCCCGG 1 -- us2k10--------
    rs1811261511,2
    C--80315186(+) CCCCTC/TCTGGC 1 -- us2k10--------
    rs1395884151,2
    --80315239(+) TCAGAA/GAAAAC 1 -- us2k10--------
    rs728561671,2
    C,F--80315339(+) CACCTG/CAGGGG 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1178503861,2
    F--80315436(+) CCCCAC/GACCTG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs728561681,2
    C,F--80315449(+) CCTATC/ACCAGG 1 -- us2k12Minor allele frequency- A:0.08NA EA 240
    rs740016261,2
    C,F--80315490(+) TGGCCC/TTGATC 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1860217221,2
    --80315570(+) CTGCCA/GGGTGG 1 -- us2k10--------
    rs1497135461,2
    --80315657(+) GTCACC/TTTCTT 1 -- us2k10--------
    rs1909281871,2
    C--80315740(+) ACTTAC/TGTCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEX19 (80317123 - 80321652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for TEX19 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716489CNV Deletion23290073
    nsv821135CNV Deletion20802225
    esv2162612CNV Deletion18987734
    esv2716490CNV Deletion23290073
    esv1367803CNV Insertion17803354
    nsv909223CNV Loss21882294
    nsv909220CNV Loss21882294
    dgv3354n71CNV Loss21882294
    dgv3357n71CNV Loss21882294
    dgv3353n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. (PubMed id 18096721)1, 2 Kuntz S....Viville S. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
    4. Molecular profiling of the human testis reveals stringent pathway- specific regulation of RNA expression following gonadotropin suppression and progestogen treatment. (PubMed id 18160741)2 Bayne R.A.... Anderson R.A. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400629 HGNC: 33802 AceView: FLJ35767 Ensembl:ENSG00000182459 euGenes: HUgn400629
    ECgene: TEX19 H-InvDB: TEX19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX19 gene:
    Search GeneIP for patents involving TEX19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX19
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TEX19
    Customized:
     lentivirus for stable overexpression of TEX19
     lentivirus expression plasmids for stable overexpression of TEX19
     adenovirus for overexpression of TEX19
     LSBio Antibodies in human, mouse, rat for TEX19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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