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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX15 Gene

protein-coding   GIFtS: 45
GCID: GC08M030689

Testis Expressed 15

(Previous name: testis expressed sequence 15)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 151 2
Cancer/Testis Antigen 421 2 3
CT422 3
Testis Expressed Sequence 151
Testis-Expressed Sequence 15 Protein2

External Ids:    HGNC: 117381   Entrez Gene: 561542   Ensembl: ENSG000001338637   OMIM: 6057955   UniProtKB: Q9BXT53   

Export aliases for TEX15 gene to outside databases

Previous GC identifers: GC08M030510 GC08M031141 GC08M030545 GC08M030746 GC08M030808 GC08M029235


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEX15 Gene: 
TEX15 (testis expressed 15) is a protein-coding gene. Diseases associated with TEX15 include azoospermia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX15 gene promoter:
         AML1a   IRF-2   POU2F1   POU2F1b   POU2F1a   IRF-7A   POU2F1c   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX15 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p22

TEX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX15 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M030689:  view genomic region     (about GC identifiers)

Start:
30,689,060 bp from pter      End:
30,748,122 bp from pter
Size:
59,063 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX15_HUMAN, Q9BXT5 (See protein sequence)
Recommended Name: Testis-expressed sequence 15 protein  
Size: 2789 amino acids; 315336 Da

Explore the universe of human proteins at neXtProt for TEX15: NX_Q9BXT5

Explore proteomics data for TEX15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXT5

  • TEX15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX15 Protein Expression
    REFSEQ proteins: NP_112561.2  
    ENSEMBL proteins: 
     ENSP00000256246  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026616 TEX15

    Graphical View of Domain Structure for InterPro Entry Q9BXT5

    ProtoNet protein and cluster: Q9BXT5


    TEX15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TEX15:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tex15):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    TEX15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX15 
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    SwitchGear 3'UTR luciferase reporter plasmidTEX15 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for TEX15 (ENSP000002562464) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMENSP000002786164STRING: ENSP00000278616
    BRCA1ENSP000003502834STRING: ENSP00000350283
    BRCA2ENSP000003694974STRING: ENSP00000369497
    RAD51ENSP000002678684STRING: ENSP00000267868
    SPO11ENSP000003603104STRING: ENSP00000360310
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007129synapsis ----
    GO:0007130synaptonemal complex assembly IEA--
    GO:0007140male meiosis IEA--
    GO:0007283spermatogenesis IEA--
    GO:0009566fertilization IEA--

    TEX15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX15

    Search CenterWatch for drugs/clinical trials and news about TEX15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX15 gene: 
    NM_031271.3  

    Unigene Clusters for TEX15:

    Testis expressed 15
    Hs.458316  [show with all ESTs], Hs.571446  [show with all ESTs]
    Unigene Representative Sequences: NM_031271, BC141841
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256246(uc003xil.3) ENST00000523186(uc011lbc.2) ENST00000518257

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX15:
    hsa-miR-3163 hsa-miR-3685 hsa-miR-607 hsa-miR-3688-3p hsa-miR-205* hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidTEX15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX15

    Additional mRNA sequence: BC141841.1 

    4 DOTS entries:

    DT.75167697  DT.121480171  DT.121480169  DT.121480170 

    16 AceView cDNA sequences:

    BX503105 AL133653 AI798060 AF285605 NM_031271 BX280519 AL705557 BG493629 
    AL703692 BQ438658 BX492383 AL705527 AA432326 BQ432876 AW303407 AL704625 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX15 expression in normal human tissues (normalized intensities)      TEX15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCAGACAT
    TEX15 Expression
    About this image


    TEX15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
             sperm   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   
     
     Gonad
             XY Germ Cells Testis Cord
     
     Choroid Plexus (Nervous System)
             Choroid Plexus Progenitor Cells Choroid Plexus

    See TEX15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX15

    SOURCE GeneReport for Unigene clusters: Hs.458316 Hs.571446

    UniProtKB/Swiss-Prot: TEX15_HUMAN, Q9BXT5
    Tissue specificity: Testis-specific. Also expressed in several cancers

        SABiosciences Custom PCR Arrays for TEX15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TEX15 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex151 , 5 testis expressed gene 151, 5 73.82(n)1
    56.25(a)1
      8 (20.59 cM)5
    1042711  NM_031374.21  NP_113551.21 
     335167385 
    zebrafish
    (Danio rerio)
    Actinopterygii tex156
    testis expressed 15
    15(a)
    1 ↔ 1
    10(6173774-6187180)


    ENSEMBL Gene Tree for TEX15 (if available)
    TreeFam Gene Tree for TEX15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/611 SNPs in TEX15 are shown (see all 611)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679997061,2
    C--30688596(-) AAAAA-/ACGTAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1999297001,2
    C--30688603(+) TTTTTC/TCTTTT 1 -- ds50010--------
    rs27206001,2
    C,H--30688659(-) tgagcC/Tgaggt 1 -- ds50019Minor allele frequency- T:0.00NA WA CSA 16
    rs27205991,2
    C,H--30688750(-) cagccG/Tggagt 1 -- ds500111Minor allele frequency- T:0.01WA NA CSA 137
    rs25517461,2
    C,F,A,H--30688805(-) CAAGAC/GCAGCC 1 -- ds50017Minor allele frequency- G:0.14NA WA CSA 14
    rs25517451,2
    C,H--30688809(-) AGTTCG/AAGAGC 1 -- ds50019Minor allele frequency- A:0.00NA WA CSA 15
    rs1888947021,2
    --30688922(+) ACAAAA/GGAAAA 1 -- ds50010--------
    rs1816907211,2
    --30689187(+) ACAATA/GTCAAC 1 -- ut310--------
    rs2016681891,2
    C--30689375(-) GTATTA/CAAAAA 1 -- ut310--------
    rs168773961,2
    C,F--30689476(+) TTTTTA/TAATAT 1 -- ut315Minor allele frequency- T:0.07NA WA 380

    HapMap Linkage Disequilibrium report for TEX15 (30689060 - 30748122 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TEX15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519692CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX15
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605795    OMIM disorders: --

    2 diseases for TEX15:    About MalaCards
    azoospermia    


    TEX15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TEX15
    Human Genome Epidemiology (HuGE) Navigator: TEX15 (1 document)

    Export disorders for TEX15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
    2. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    3. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PubMed id 12704671)1, 2 Loriot A.... De Smet C. (2003)
    4. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    5. Genetic variants in TEX15 gene conferred susceptibilit y to spermatogenic failure in the Chinese Han population. (PubMed id 22581801)1 Ruan J....Zhang X.J. (2012)
    6. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    7. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56154 HGNC: 11738 AceView: TEX15 Ensembl:ENSG00000133863 euGenes: HUgn56154
    ECgene: TEX15 H-InvDB: TEX15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX15 gene:
    Search GeneIP for patents involving TEX15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for TEX15
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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