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Aliases for TEX15 Gene

Aliases for TEX15 Gene

  • Testis Expressed 15, Meiosis And Synapsis Associated 2 3
  • Cancer/Testis Antigen 42 2 3 4
  • Testis Expressed 15 2 3 5
  • CT42 3 4
  • Testis-Expressed Sequence 15 Protein 3
  • Testis Expressed Sequence 15 2

External Ids for TEX15 Gene

Previous GeneCards Identifiers for TEX15 Gene

  • GC08M030510
  • GC08M031141
  • GC08M030545
  • GC08M030746
  • GC08M029235
  • GC08M030689

Summaries for TEX15 Gene

GeneCards Summary for TEX15 Gene

TEX15 (Testis Expressed 15, Meiosis And Synapsis Associated) is a Protein Coding gene. Among its related pathways are Meiosis and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for TEX15 Gene

  • Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX15 Gene

Genomics for TEX15 Gene

Regulatory Elements for TEX15 Gene

Enhancers for TEX15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F031049 0.6 FANTOM5 1.8 -136.6 -136622 0.3 ATF2 TEX15 PURG SUMO2P16
GH08F030911 1.2 Ensembl ENCODE 0.8 +0.6 638 2.0 ATF1 CREB3L1 ARID4B ZNF2 GLIS2 CBX5 SP3 REST SMARCA4 GLIS1 PPP2CB TEX15 LOC105379357
GH08F030919 0.6 ENCODE 0.4 -6.1 -6105 0.2 GTF2F1 CTCF ZNF654 TEAD1 TEAD4 TRIM22 REST ZNF2 RAD21 TEAD3 ENSG00000253204 TEX15
GH08F030920 0.2 Ensembl 0.4 -6.3 -6286 0.2 GTF2F1 CTCF ZNF654 TEAD4 TRIM22 REST ZNF2 RAD21 ZNF121 ZBTB48 LOC105379359 ENSG00000253204 TEX15
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TEX15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEX15 Gene

Chromosome:
8
Start:
30,831,423 bp from pter
End:
30,913,015 bp from pter
Size:
81,593 bases
Orientation:
Minus strand

Genomic View for TEX15 Gene

Genes around TEX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX15 Gene

Proteins for TEX15 Gene

  • Protein details for TEX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT5-TEX15_HUMAN
    Recommended name:
    Testis-expressed sequence 15 protein
    Protein Accession:
    Q9BXT5

    Protein attributes for TEX15 Gene

    Size:
    2789 amino acids
    Molecular mass:
    315336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX15 Gene

Post-translational modifications for TEX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEX15 Gene

Domains & Families for TEX15 Gene

Protein Domains for TEX15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BXT5

UniProtKB/Swiss-Prot:

TEX15_HUMAN :
  • Belongs to the TEX15 family.
Family:
  • Belongs to the TEX15 family.
genes like me logo Genes that share domains with TEX15: view

No data available for Gene Families for TEX15 Gene

Function for TEX15 Gene

Molecular function for TEX15 Gene

UniProtKB/Swiss-Prot Function:
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.
genes like me logo Genes that share phenotypes with TEX15: view

Animal Models for TEX15 Gene

MGI Knock Outs for TEX15:

Animal Model Products

miRNA for TEX15 Gene

miRTarBase miRNAs that target TEX15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX15 Gene

Localization for TEX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX15 Gene COMPARTMENTS Subcellular localization image for TEX15 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TEX15: view

Pathways & Interactions for TEX15 Gene

SuperPathways for TEX15 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with TEX15: view

Pathways by source for TEX15 Gene

3 Reactome pathways for TEX15 Gene

Gene Ontology (GO) - Biological Process for TEX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007129 synapsis IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007140 male meiosis IEA --
genes like me logo Genes that share ontologies with TEX15: view

No data available for SIGNOR curated interactions for TEX15 Gene

Transcripts for TEX15 Gene

mRNA/cDNA for TEX15 Gene

Unigene Clusters for TEX15 Gene

Testis expressed 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX15 Gene

No ASD Table

Relevant External Links for TEX15 Gene

GeneLoc Exon Structure for
TEX15
ECgene alternative splicing isoforms for
TEX15

Expression for TEX15 Gene

mRNA expression in normal human tissues for TEX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX15 Gene

This gene is overexpressed in Testis (x23.2) and Uterus (x11.0).

Protein differential expression in normal tissues from HIPED for TEX15 Gene

This gene is overexpressed in Heart (32.1) and Liver, secretome (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX15 Gene



Protein tissue co-expression partners for TEX15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX15 Gene:

TEX15

SOURCE GeneReport for Unigene cluster for TEX15 Gene:

Hs.458316

mRNA Expression by UniProt/SwissProt for TEX15 Gene:

Q9BXT5-TEX15_HUMAN
Tissue specificity: Detected in testis and ovary (PubMed:11279525). Also expressed in several cancers (PubMed:12704671).
genes like me logo Genes that share expression patterns with TEX15: view

Primer Products

Orthologs for TEX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX15 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia TEX15 34 35
  • 82.29 (n)
cow
(Bos Taurus)
Mammalia TEX15 34 35
  • 78.59 (n)
mouse
(Mus musculus)
Mammalia Tex15 34 16 35
  • 73.46 (n)
rat
(Rattus norvegicus)
Mammalia Tex15 34
  • 69.92 (n)
oppossum
(Monodelphis domestica)
Mammalia TEX15 35
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEX15 35
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tex15 35
  • 15 (a)
OneToOne
Species where no ortholog for TEX15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX15 Gene

ENSEMBL:
Gene Tree for TEX15 (if available)
TreeFam:
Gene Tree for TEX15 (if available)

Paralogs for TEX15 Gene

No data available for Paralogs for TEX15 Gene

Variants for TEX15 Gene

Sequence variations from dbSNP and Humsavar for TEX15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs864309485 Pathogenic 30,846,888(-) TCATA(G/T)AAGGC reference, stop-gained
rs10086531 -- 30,900,186(+) TAGTT(C/T)GTGTA intron-variant
rs10087920 -- 30,841,978(+) TTATA(A/G)AAGTT intron-variant, downstream-variant-500B
rs10088023 -- 30,896,075(+) GACTA(C/T)TGGTA intron-variant
rs10089478 -- 30,914,209(+) GTGCA(C/T)TGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEX15 Gene

Variant ID Type Subtype PubMed ID
nsv519692 CNV gain 19592680

Variation tolerance for TEX15 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.67; 95.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX15 Gene

Human Gene Mutation Database (HGMD)
TEX15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX15 Gene

Disorders for TEX15 Gene

Relevant External Links for TEX15

Genetic Association Database (GAD)
TEX15
Human Genome Epidemiology (HuGE) Navigator
TEX15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX15

No disorders were found for TEX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX15 Gene

Publications for TEX15 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 64
  2. Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family. (PMID: 26199321) Okutman O. … Viville S. (Hum. Mol. Genet. 2015) 2 3 64
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  4. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. (PMID: 18283110) Yang F. … Wang P.J. (J. Cell Biol. 2008) 2 3 64
  5. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PMID: 12704671) Loriot A. … De Smet C. (Int. J. Cancer 2003) 3 4 64

Products for TEX15 Gene

Sources for TEX15 Gene

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