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Aliases for TEX15 Gene

Aliases for TEX15 Gene

  • Testis Expressed 15 2 3 5
  • Cancer/Testis Antigen 42 2 3 4
  • CT42 3 4
  • Testis Expressed Sequence 15 2

External Ids for TEX15 Gene

Previous GeneCards Identifiers for TEX15 Gene

  • GC08M030510
  • GC08M031141
  • GC08M030545
  • GC08M030746
  • GC08M029235
  • GC08M030689

Summaries for TEX15 Gene

GeneCards Summary for TEX15 Gene

TEX15 (Testis Expressed 15) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for TEX15 Gene

  • Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX15 Gene

Genomics for TEX15 Gene

Regulatory Elements for TEX15 Gene

Genomic Location for TEX15 Gene

Chromosome:
8
Start:
30,831,423 bp from pter
End:
30,913,015 bp from pter
Size:
81,593 bases
Orientation:
Minus strand

Genomic View for TEX15 Gene

Genes around TEX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX15 Gene

Proteins for TEX15 Gene

  • Protein details for TEX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT5-TEX15_HUMAN
    Recommended name:
    Testis-expressed sequence 15 protein
    Protein Accession:
    Q9BXT5

    Protein attributes for TEX15 Gene

    Size:
    2789 amino acids
    Molecular mass:
    315336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX15 Gene

Proteomics data for TEX15 Gene at MOPED

Post-translational modifications for TEX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX15 Gene

Domains & Families for TEX15 Gene

Protein Domains for TEX15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BXT5

UniProtKB/Swiss-Prot:

TEX15_HUMAN :
  • Belongs to the TEX15 family.
Family:
  • Belongs to the TEX15 family.
genes like me logo Genes that share domains with TEX15: view

No data available for Gene Families for TEX15 Gene

Function for TEX15 Gene

Molecular function for TEX15 Gene

UniProtKB/Swiss-Prot Function:
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.
genes like me logo Genes that share phenotypes with TEX15: view

Animal Models for TEX15 Gene

MGI Knock Outs for TEX15:

Animal Model Products

miRNA for TEX15 Gene

miRTarBase miRNAs that target TEX15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX15 Gene

Localization for TEX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX15 Gene COMPARTMENTS Subcellular localization image for TEX15 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TEX15 Gene

Pathways & Interactions for TEX15 Gene

SuperPathways for TEX15 Gene

Superpath Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with TEX15: view

Pathways by source for TEX15 Gene

3 Reactome pathways for TEX15 Gene

Interacting Proteins for TEX15 Gene

Gene Ontology (GO) - Biological Process for TEX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007140 male meiosis IEA --
GO:0007283 spermatogenesis IEA --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with TEX15: view

No data available for SIGNOR curated interactions for TEX15 Gene

Drugs & Compounds for TEX15 Gene

No Compound Related Data Available

Transcripts for TEX15 Gene

mRNA/cDNA for TEX15 Gene

Unigene Clusters for TEX15 Gene

Testis expressed 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEX15 Gene

No ASD Table

Relevant External Links for TEX15 Gene

GeneLoc Exon Structure for
TEX15
ECgene alternative splicing isoforms for
TEX15

Expression for TEX15 Gene

mRNA expression in normal human tissues for TEX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX15 Gene

This gene is overexpressed in Testis (x23.2) and Uterus (x11.0).

Protein differential expression in normal tissues from HIPED for TEX15 Gene

This gene is overexpressed in Heart (32.1) and Liver, secretome (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX15 Gene



SOURCE GeneReport for Unigene cluster for TEX15 Gene Hs.458316

mRNA Expression by UniProt/SwissProt for TEX15 Gene

Q9BXT5-TEX15_HUMAN
Tissue specificity: Detected in testis and ovary (PubMed:11279525). Also expressed in several cancers (PubMed:12704671).
genes like me logo Genes that share expression patterns with TEX15: view

Protein tissue co-expression partners for TEX15 Gene

Primer Products

In Situ Assay Products

Orthologs for TEX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEX15 35
  • 78.59 (n)
  • 63.44 (a)
TEX15 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEX15 35
  • 82.29 (n)
  • 68.54 (a)
TEX15 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tex15 35
  • 73.46 (n)
  • 55.92 (a)
Tex15 16
Tex15 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEX15 35
  • 99.26 (n)
  • 98.53 (a)
TEX15 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex15 35
  • 69.92 (n)
  • 52.54 (a)
oppossum
(Monodelphis domestica)
Mammalia TEX15 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEX15 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tex15 36
  • 15 (a)
OneToOne
Species with no ortholog for TEX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX15 Gene

ENSEMBL:
Gene Tree for TEX15 (if available)
TreeFam:
Gene Tree for TEX15 (if available)

Paralogs for TEX15 Gene

No data available for Paralogs for TEX15 Gene

Variants for TEX15 Gene

Sequence variations from dbSNP and Humsavar for TEX15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs323347 - 30,848,708(+) AGCAC(A/G)ATCAC reference, missense
rs9297162 - 30,847,870(+) GTTTC(A/G)GGAAA reference, missense
rs323346 - 30,845,915(+) TATTA(C/T)TGCAT reference, missense
rs323345 - 30,845,086(+) TAATG(C/T)TTTGT reference, missense
rs323344 - 30,845,009(+) TGATA(A/C)CTGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TEX15 Gene

Variant ID Type Subtype PubMed ID
nsv519692 CNV Gain 19592680

Variation tolerance for TEX15 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.67; 95.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX15 Gene

HapMap Linkage Disequilibrium report
TEX15
Human Gene Mutation Database (HGMD)
TEX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX15 Gene

Disorders for TEX15 Gene

Relevant External Links for TEX15

Genetic Association Database (GAD)
TEX15
Human Genome Epidemiology (HuGE) Navigator
TEX15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX15

No disorders were found for TEX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX15 Gene

Publications for TEX15 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3
  4. Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population. (PMID: 22581801) Ruan J. … Zhang X.J. (Reprod Sci 2012) 3
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3

Products for TEX15 Gene

Sources for TEX15 Gene

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