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Aliases for TEX14 Gene

Aliases for TEX14 Gene

  • Testis Expressed 14, Intercellular Bridge Forming Factor 2 3 5
  • Testis-Expressed Sequence 14 Protein 3 4
  • Protein Kinase-Like Protein SgK307 3 4
  • Cancer/Testis Antigen 113 2 3
  • Sugen Kinase 307 3 4
  • Inactive Serine/Threonine-Protein Kinase TEX14 3
  • Testis Expressed Sequence 14 2
  • Testis-Expressed Sequence 14 4
  • Testis-Expressed Protein 14 3
  • Testis Expressed 14 2
  • SGK307 4
  • CT113 3

External Ids for TEX14 Gene

Previous GeneCards Identifiers for TEX14 Gene

  • GC17M056378
  • GC17M059115
  • GC17M056976
  • GC17M057108
  • GC17M053989
  • GC17M056634
  • GC17M051994

Summaries for TEX14 Gene

Entrez Gene Summary for TEX14 Gene

  • The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for TEX14 Gene

TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for TEX14 Gene

  • Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX14 Gene

Genomics for TEX14 Gene

Regulatory Elements for TEX14 Gene

Enhancers for TEX14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058630 1.2 ENCODE 16.5 +60.2 60198 2.6 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TRIM37 RAD51C SRSF1 VEZF1 TEX14 RNU1-108P SMG8 MTMR4 DHX40 GC17M058632
GH17F058785 1.3 Ensembl ENCODE 12 -94.7 -94650 1.5 PKNOX1 ATF1 ARNT SIN3A FEZF1 GATA2 FOS JUNB ZHX2 NCOA1 TRIM37 TEX14 PPM1E ENSG00000276601 GC17P058810
GH17F059328 1.5 FANTOM5 ENCODE 7.8 -638.5 -638481 6.0 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 TEX14 YPEL2 SKA2 SNRPGP17
GH17F058005 2.2 ENCODE 4.3 +685.6 685575 4.1 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 SRSF1 VEZF1 ENSG00000264914 OR4D1 LOC101927557 SETP3 CCDC182 IGBP1P2 TEX14 ENSG00000266086
GH17F059295 1 ENCODE 8.9 -604.9 -604928 2.3 PKNOX1 ATF1 ARNT ARID4B ZNF48 GTF3C2 FOS PPARG KAT8 SREBF1 NDUFB8P2 SMG8 RPS6KB1 TEX14 ENSG00000265415 SNRPGP17 YPEL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEX14 on UCSC Golden Path with GeneCards custom track

Promoters for TEX14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001808470 -21 201 BRD4 ATF1 ZNF175 ZNF644 ZNF2 RELA ZNF664 POLR2A ZNF202 ZNF639

Genomic Location for TEX14 Gene

Chromosome:
17
Start:
58,556,677 bp from pter
End:
58,692,079 bp from pter
Size:
135,403 bases
Orientation:
Minus strand

Genomic View for TEX14 Gene

Genes around TEX14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX14 Gene

Proteins for TEX14 Gene

  • Protein details for TEX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB6-TEX14_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase TEX14
    Protein Accession:
    Q8IWB6
    Secondary Accessions:
    • A6NH19
    • Q7RTP3
    • Q8ND97
    • Q9BXT9

    Protein attributes for TEX14 Gene

    Size:
    1497 amino acids
    Molecular mass:
    167901 Da
    Quaternary structure:
    • Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 (By similarity).
    SequenceCaution:
    • Sequence=AAK31980.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEX14 Gene

    Alternative splice isoforms for TEX14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX14 Gene

Post-translational modifications for TEX14 Gene

  • Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEX14 Gene

Domains & Families for TEX14 Gene

Gene Families for TEX14 Gene

Suggested Antigen Peptide Sequences for TEX14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWB6

UniProtKB/Swiss-Prot:

TEX14_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily.
  • Contains 3 ANK repeats.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • The GPPX3Y motif mediates interaction with CEP55.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with TEX14: view

Function for TEX14 Gene

Molecular function for TEX14 Gene

UniProtKB/Swiss-Prot Function:
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 20176808
GO:0005524 ATP binding IEA --
GO:0019901 protein kinase binding IPI 22405274
genes like me logo Genes that share ontologies with TEX14: view
genes like me logo Genes that share phenotypes with TEX14: view

Animal Models for TEX14 Gene

MGI Knock Outs for TEX14:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TEX14 Gene

Localization for TEX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX14 Gene

Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX14 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore ISS,IBA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005623 cell ISS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TEX14: view

Pathways & Interactions for TEX14 Gene

SuperPathways for TEX14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint ISS,IBA --
GO:0007140 male meiosis ISS,IBA --
genes like me logo Genes that share ontologies with TEX14: view

No data available for Pathways by source and SIGNOR curated interactions for TEX14 Gene

Transcripts for TEX14 Gene

Unigene Clusters for TEX14 Gene

Testis expressed 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6:

ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for TEX14 Gene

GeneLoc Exon Structure for
TEX14
ECgene alternative splicing isoforms for
TEX14

Expression for TEX14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX14 Gene

This gene is overexpressed in Testis (x27.2).

Protein differential expression in normal tissues from HIPED for TEX14 Gene

This gene is overexpressed in Testis (31.9), Serum (14.5), Fetal Brain (10.3), and Ovary (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX14 Gene



Protein tissue co-expression partners for TEX14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX14 Gene:

TEX14

SOURCE GeneReport for Unigene cluster for TEX14 Gene:

Hs.390221

mRNA Expression by UniProt/SwissProt for TEX14 Gene:

Q8IWB6-TEX14_HUMAN
Tissue specificity: Detected in testis.
genes like me logo Genes that share expression patterns with TEX14: view

Primer Products

Orthologs for TEX14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX14 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia TEX14 34 35
  • 84.66 (n)
cow
(Bos Taurus)
Mammalia TEX14 34 35
  • 83.45 (n)
rat
(Rattus norvegicus)
Mammalia Tex14 34
  • 79.18 (n)
mouse
(Mus musculus)
Mammalia Tex14 34 16 35
  • 78.27 (n)
oppossum
(Monodelphis domestica)
Mammalia TEX14 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEX14 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEX14 34 35
  • 55.1 (n)
lizard
(Anolis carolinensis)
Reptilia TEX14 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TEX14 35
  • 45 (a)
OneToOne
Species where no ortholog for TEX14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX14 Gene

ENSEMBL:
Gene Tree for TEX14 (if available)
TreeFam:
Gene Tree for TEX14 (if available)

Paralogs for TEX14 Gene

Pseudogenes.org Pseudogenes for TEX14 Gene

genes like me logo Genes that share paralogs with TEX14: view

No data available for Paralogs for TEX14 Gene

Variants for TEX14 Gene

Sequence variations from dbSNP and Humsavar for TEX14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_041389 A gastric adenocarcinoma sample
rs587780840 Pathogenic 58,692,740(+) GGTTC(-/CA)GACTG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs587782528 Pathogenic 58,692,740(+) GGTTC(C/T)AGACT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs730881942 Pathogenic 58,692,736(+) GCGGG(-/G)TTCCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs757128712 Pathogenic 58,692,789(+) CAAAG(A/G)TAACG intron-variant, upstream-variant-2KB, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX14 Gene

Variant ID Type Subtype PubMed ID
nsv962346 CNV duplication 23825009
nsv833498 CNV loss 17160897
nsv575801 CNV loss 21841781
nsv515871 CNV loss 19592680
nsv477144 CNV novel sequence insertion 20440878
nsv457863 CNV loss 19166990
nsv428347 CNV gain 18775914
nsv1152637 CNV insertion 26484159
nsv1138560 CNV deletion 24896259
nsv1066945 CNV loss 25217958
esv3640891 CNV loss 21293372
esv3640889 CNV loss 21293372
esv3582848 CNV loss 25503493
esv3582847 CNV loss 25503493
esv2758698 CNV gain 17122850
esv2671957 CNV deletion 23128226
esv2661744 CNV deletion 23128226
esv2657166 CNV deletion 23128226

Variation tolerance for TEX14 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX14 Gene

Human Gene Mutation Database (HGMD)
TEX14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX14 Gene

Disorders for TEX14 Gene

Relevant External Links for TEX14

Genetic Association Database (GAD)
TEX14
Human Genome Epidemiology (HuGE) Navigator
TEX14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX14

No disorders were found for TEX14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX14 Gene

Publications for TEX14 Gene

  1. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PMID: 12711554) Wu M.-H. … Matzuk M.M. (Gene Expr. Patterns 2003) 2 3 4 64
  2. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 64
  3. Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. (PMID: 26392564) Kim H.J. … Lee H.H. (Proc. Natl. Acad. Sci. U.S.A. 2015) 2 3 64
  4. Tex14, a plk1-regulated protein, is required for kinetochore- microtubule attachment and regulation of the spindle assembly checkpoint. (PMID: 22405274) Mondal G. … Couch F.J. (Mol. Cell 2012) 3 4 64
  5. TEX14 interacts with CEP55 to block cell abscission. (PMID: 20176808) Iwamori T. … Matzuk M.M. (Mol. Cell. Biol. 2010) 3 4 64

Products for TEX14 Gene

Sources for TEX14 Gene

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