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Aliases for TEX14 Gene

Aliases for TEX14 Gene

  • Testis Expressed 14 2 3
  • Testis-Expressed Sequence 14 Protein 3 4
  • Protein Kinase-Like Protein SgK307 3 4
  • Testis Expressed Sequence 14 2 3
  • Cancer/Testis Antigen 113 2 3
  • Sugen Kinase 307 3 4
  • Inactive Serine/Threonine-Protein Kinase TEX14 3
  • Testis-Expressed Sequence 14 4
  • Testis-Expressed Protein 14 3
  • SGK307 4
  • CT113 3

External Ids for TEX14 Gene

Summaries for TEX14 Gene

Entrez Gene Summary for TEX14 Gene

  • The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for TEX14 Gene

TEX14 (Testis Expressed 14) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and protein kinase activity.

UniProtKB/Swiss-Prot for TEX14 Gene

  • Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX14 Gene

Genomics for TEX14 Gene

Genomic Location for TEX14 Gene

Start:
58,556,677 bp from pter
End:
58,692,055 bp from pter
Size:
135,379 bases
Orientation:
Minus strand

Genomic View for TEX14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX14 Gene

Regulatory Elements for TEX14 Gene

Proteins for TEX14 Gene

  • Protein details for TEX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB6-TEX14_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase TEX14
    Protein Accession:
    Q8IWB6
    Secondary Accessions:
    • A6NH19
    • Q7RTP3
    • Q8ND97
    • Q9BXT9

    Protein attributes for TEX14 Gene

    Size:
    1497 amino acids
    Molecular mass:
    167901 Da
    Quaternary structure:
    • Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 (By similarity).
    SequenceCaution:
    • Sequence=AAK31980.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX14 Gene

Proteomics data for TEX14 Gene at MOPED

Post-translational modifications for TEX14 Gene

  • Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX14 Gene

No data available for DME Specific Peptides for TEX14 Gene

Domains for TEX14 Gene

Gene Families for TEX14 Gene

Suggested Antigen Peptide Sequences for TEX14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWB6

UniProtKB/Swiss-Prot:

TEX14_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q8IWB6
  • The GPPX3Y motif mediates interaction with CEP55:
    • Q8IWB6
  • Contains 1 protein kinase domain.:
    • Q8IWB6
Family:
  • Belongs to the protein kinase superfamily.:
    • Q8IWB6
Similarity:
  • Contains 3 ANK repeats.:
    • Q8IWB6
genes like me logo Genes that share domains with TEX14: view

Function for TEX14 Gene

Molecular function for TEX14 Gene

UniProtKB/Swiss-Prot Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20176808
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with TEX14: view
genes like me logo Genes that share phenotypes with TEX14: view

Animal Models for TEX14 Gene

MGI Knock Outs for TEX14:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TEX14 Gene

Localization for TEX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX14 Gene

Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX14 Gene COMPARTMENTS Subcellular localization image for TEX14 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore ISS --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005623 cell ISS --
GO:0005737 cytoplasm IEA --
GO:0030496 midbody ISS --
genes like me logo Genes that share ontologies with TEX14: view

Pathways for TEX14 Gene

SuperPathways for TEX14 Gene

No Data Available

Interacting Proteins for TEX14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000240361%0d%0a9606.ENSP00000360540%0d%0a9606.ENSP00000260363%0d%0a
Selected Interacting proteins: ENSP00000240361 Q8IWB6-TEX14_HUMAN for TEX14 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007094 mitotic spindle assembly checkpoint ISS --
GO:0007140 male meiosis ISS --
GO:0008608 attachment of spindle microtubules to kinetochore ISS --
GO:0032091 negative regulation of protein binding IEA --
genes like me logo Genes that share ontologies with TEX14: view

No data available for Pathways by source for TEX14 Gene

Transcripts for TEX14 Gene

Unigene Clusters for TEX14 Gene

Testis expressed 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6:

ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for TEX14 Gene

GeneLoc Exon Structure for
TEX14
ECgene alternative splicing isoforms for
TEX14

Expression for TEX14 Gene

mRNA expression in normal human tissues for TEX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX14 Gene

This gene is overexpressed in Testis (27.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEX14 Gene

SOURCE GeneReport for Unigene cluster for TEX14 Gene Hs.390221

mRNA Expression by UniProt/SwissProt for TEX14 Gene

Q8IWB6-TEX14_HUMAN
Tissue specificity: Detected in testis.
genes like me logo Genes that share expressions with TEX14: view

Orthologs for TEX14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX14 35
  • 99.22 (n)
  • 98.66 (a)
TEX14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEX14 35
  • 83.45 (n)
  • 76.82 (a)
TEX14 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEX14 35
  • 84.66 (n)
  • 78.5 (a)
TEX14 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tex14 35
  • 78.27 (n)
  • 68.54 (a)
Tex14 16
Tex14 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEX14 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEX14 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex14 35
  • 79.18 (n)
  • 69.97 (a)
chicken
(Gallus gallus)
Aves TEX14 35
  • 55.1 (n)
  • 43.84 (a)
TEX14 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEX14 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TEX14 36
  • 45 (a)
OneToOne
Species with no ortholog for TEX14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX14 Gene

ENSEMBL:
Gene Tree for TEX14 (if available)
TreeFam:
Gene Tree for TEX14 (if available)

Paralogs for TEX14 Gene

Pseudogenes.org Pseudogenes for TEX14 Gene

genes like me logo Genes that share paralogs with TEX14: view

No data available for Paralogs for TEX14 Gene

Variants for TEX14 Gene

Sequence variations from dbSNP and Humsavar for TEX14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs149571 -- 58,669,667(+) aggca(A/G)aggtt intron-variant
rs150558 -- 58,674,742(-) tgtaa(A/G)aaatc intron-variant
rs159980 -- 58,685,294(-) cacac(C/T)cagct intron-variant
rs160047 -- 58,683,377(-) tttgg(A/C/G)ggggg intron-variant
rs167347 -- 58,683,103(-) gagcc(A/C)ccgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX14 Gene

Variant ID Type Subtype PubMed ID
dgv994e1 CNV Complex 17122850
nsv428347 CNV Gain 18775914
nsv908642 CNV Loss 21882294
esv2671957 CNV Deletion 23128226
nsv457863 CNV Loss 19166990
nsv515871 CNV Loss 19592680
nsv833498 CNV Loss 17160897
esv2661744 CNV Deletion 23128226
esv2657166 CNV Deletion 23128226

Relevant External Links for TEX14 Gene

HapMap Linkage Disequilibrium report
TEX14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX14 Gene

Disorders for TEX14 Gene

Relevant External Links for TEX14

Genetic Association Database (GAD)
TEX14
Human Genome Epidemiology (HuGE) Navigator
TEX14
genes like me logo Genes that share disorders with TEX14: view

No data available for UniProtKB/Swiss-Prot for TEX14 Gene

Publications for TEX14 Gene

  1. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PMID: 12711554) Wu M.-H. … Matzuk M.M. (Gene Expr. Patterns 2003) 2 3 4
  2. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. TEX14 interacts with CEP55 to block cell abscission. (PMID: 20176808) Iwamori T. … Matzuk M.M. (Mol. Cell. Biol. 2010) 3 4
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 48

Products for TEX14 Gene

Sources for TEX14 Gene

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