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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX14 Gene

protein-coding   GIFtS: 50
GCID: GC17M056634

Testis Expressed 14

(Previous name: testis expressed sequence 14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 141 2     CT1132
Testis Expressed Sequence 141 2     Inactive Serine/Threonine-Protein Kinase TEX142
Cancer/Testis Antigen 1131 2     Testis-Expressed Protein 142
Protein Kinase-Like Protein SgK3072 3     SGK3073
Sugen Kinase 3072 3     Testis-Expressed Sequence 143
Testis-Expressed Sequence 14 Protein2 3     

External Ids:    HGNC: 117371   Entrez Gene: 561552   Ensembl: ENSG000001211017   OMIM: 6057925   UniProtKB: Q8IWB63   

Export aliases for TEX14 gene to outside databases

Previous GC identifers: GC17M056378 GC17M059115 GC17M056976 GC17M057108 GC17M053989 GC17M051994


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEX14 Gene:
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for
spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Jan 2011)

GeneCards Summary for TEX14 Gene: 
TEX14 (testis expressed 14) is a protein-coding gene. Diseases associated with TEX14 include azoospermia, and pancreatic cancer. GO annotations related to this gene include protein kinase binding and protein kinase activity.

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule
attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect
differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the
conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55
inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to
transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by
PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has
no protein kinase activity in vitro (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX14 gene promoter:
         SREBP-1c   Tal-1beta   SREBP-1b   E47   SREBP-1a   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

TEX14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056634:  view genomic region     (about GC identifiers)

Start:
56,634,038 bp from pter      End:
56,769,416 bp from pter
Size:
135,379 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6 (See protein sequence)
Recommended Name: Inactive serine/threonine-protein kinase TEX14  
Size: 1497 amino acids; 167901 Da
Subunit: Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and
PDCD6IP/ALIX and TSG101 (By similarity)
Subcellular location: Cytoplasm (By similarity). Midbody (By similarity). Chromosome, centromere, kinetochore (By
similarity). Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell
division (By similarity)
Caution: Ser-376 is present instead of the conserved Asp which is expected to be an active site residue
Sequence caution: Sequence=AAK31980.1; Type=Erroneous initiation;
Secondary accessions: A6NH19 Q7RTP3 Q8ND97 Q9BXT9
Alternative splicing: 3 isoforms:  Q8IWB6-1   Q8IWB6-2   Q8IWB6-3   

Explore the universe of human proteins at neXtProt for TEX14: NX_Q8IWB6

Explore proteomics data for TEX14 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and
    recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid
    depletion from kinetochores and its subsequent degradation by the APC/C complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWB6

  • TEX14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX14 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001188386.1  NP_112562.3  NP_938207.2  

    ENSEMBL proteins: 
     ENSP00000374584   ENSP00000240361   ENSP00000268910   ENSP00000463593   ENSP00000463243  

    Human Recombinant Protein Products for TEX14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TEX14
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TEX14
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    Novus Biologicals TEX14 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TEX14 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore ISS--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005623cell ISS--
    GO:0005737cytoplasm IEA--
    GO:0030496midbody ISS--

    TEX14 for ontologies           About GeneDecksing



    TEX14 Antibody Products: 
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    ThermoFisher Antibodies for TEX14
    LSBio Antibodies in human, mouse, rat for TEX14 

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    Cloud-Clone Corp. CLIAs for TEX14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis expressed 14 
    NKF5 family

    5 InterPro protein domains:
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q8IWB6

    ProtoNet protein and cluster: Q8IWB6

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Domain: The GPPX3Y motif mediates interaction with CEP55
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 protein kinase domain


    TEX14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEX14_HUMAN, Q8IWB6
    Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule
    attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect
    differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the
    conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55
    inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to
    transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by
    PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has
    no protein kinase activity in vitro (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    TEX14 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TEX14:
     Decreased DCP1a protein expres  Decreased focal adhesion (FA)   Increased cell death in HCC-19 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tex14):
     endocrine/exocrine gland  reproductive system 

    TEX14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tex14tm1Zuk for TEX14

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TEX14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEX14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEX14 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX14
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX14:
    hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTEX14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TEX14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX14

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TEX14

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TEX14 (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14
    Sirion Biotech Customized lentivirus for stable overexpression of TEX14 
                         Customized lentivirus expression plasmids for stable overexpression of TEX14 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TEX14
    Search LifeMap BioReagents cell lines for TEX14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX14

    1 Interacting protein for TEX14 (Q8IWB61) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ41EBI-6674697,EBI-747776
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007094mitotic spindle assembly checkpoint ISS--
    GO:0007140male meiosis ISS--
    GO:0008608attachment of spindle microtubules to kinetochore ISS--
    GO:0032091negative regulation of protein binding IEA--

    TEX14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX14

    Search CenterWatch for drugs/clinical trials and news about TEX14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX14 gene (3 alternative transcripts): 
    NM_001201457.1  NM_031272.4  NM_198393.3  

    Unigene Cluster for TEX14:

    Testis expressed 14
    Hs.390221  [show with all ESTs]
    Unigene Representative Sequence: AL834143
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389934(uc010dcz.2 uc002iwr.2 uc002iws.2) ENST00000584699
    ENST00000240361 ENST00000349033 ENST00000582740(uc010dda.2) ENST00000581147

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX14
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX14:
    hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTEX14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TEX14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX14
    Clone
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    OriGene ORF clones in mouse, rat for TEX14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14
    Sirion Biotech Customized lentivirus for stable overexpression of TEX14 
                         Customized lentivirus expression plasmids for stable overexpression of TEX14 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TEX14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TEX14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEX14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX14

    Additional mRNA sequence: 

    AF285601.1 AK125896.1 AK128217.1 AK308299.1 AL834143.1 BC040526.1 BC045647.1 

    8 DOTS entries:

    DT.100020711  DT.101981853  DT.101981854  DT.100020710  DT.103253  DT.97835969  DT.70100320  DT.75160863 

    24/37 AceView cDNA sequences (see all 37):

    AI291807 BM799864 BM560425 CB529131 AL834143 AK128217 AK125896 AW183151 
    AF285601 BC045647 NM_031272 AW663984 NM_198393 BK000998 BC040526 CB044007 
    AW183728 AI381395 AL040739 AW505113 AI827755 BX109653 AL040738 AA770308 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:                    -                                                                                                                                       
    SP2:                                            -     -                                                                                               -         
    SP3:                    -                             -                                                                                               -         
    SP4:                    -                             -                 -     -     -     -     -     -     -                                                   
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                  -                                       
    SP2:                                                  -                                       
    SP3:                                                  -                                       
    SP4:                                                  -                                       
    SP5:  -                                                                                       


    ECgene alternative splicing isoforms for TEX14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX14 expression in normal human tissues (normalized intensities)      TEX14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACACAGC
    TEX14 Expression
    About this image


    TEX14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
             sperm   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             cd31+ cells   
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             ES-J1
     
     Gonad
             XY Germ Cells Testis Cord

    See TEX14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX14

    SOURCE GeneReport for Unigene cluster: Hs.390221

    UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
    Tissue specificity: Detected in testis

        SABiosciences Custom PCR Arrays for TEX14
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TEX14 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex141 , 5 testis expressed gene 141, 5 78.41(n)1
    68.54(a)1
      11 (52.09 cM)5
    835601  NM_001199293.11  NP_001186222.11 
     874050655 
    chicken
    (Gallus gallus)
    Aves TEX141 testis expressed 14 57.59(n)
    47.61(a)
      417625  XM_415869.3  XP_415869.3 
    lizard
    (Anolis carolinensis)
    Reptilia TEX146
    --
    --
    66(a)
    41(a)
    1 ↔ 1
    possible ortholog
    AAWZ02039879(934-6822)
    2(191844547-191856029)
    zebrafish
    (Danio rerio)
    Actinopterygii TEX146
    testis expressed 14
    44(a)
    1 ↔ 1
    10(34376652-34378701)


    ENSEMBL Gene Tree for TEX14 (if available)
    TreeFam Gene Tree for TEX14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEX14 gene

    TEX14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TEX14
    PGOHUM00000234292


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2681 SNPs in TEX14 are shown (see all 2681)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413894
    A gastric adenocarcinoma sample4--see VAR_0413892 K E mis40--------
    VAR_0413904
    ----see VAR_0413902 S C mis40--------
    VAR_0413914
    ----see VAR_0413912 I M mis40--------
    rs354487511,2
    C--52069070(+) ACACA-/AATA  
            
    TCTCC
    3 -- int11Minor allele frequency- AATA:0.00NA 2
    rs348575631,2
    C--52095793(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs105654821,2
    C--52104313(+) acggc-/A/AAA 
            
    aaaaa
    3 -- int11NA 2
    rs1510301671,2
    --56633679(+) TTTTTA/GATTTT 3 -- ds50010--------
    rs1859831451,2
    --56633818(+) TGTACG/TTTGAT 3 -- ds50010--------
    rs1173432101,2
    F--56633979(+) TGGGTG/TGCAGT 3 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1176838581,2
    F--56634024(+) ATATAT/CCTTAC 3 -- ds50011Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for TEX14 (56634038 - 56769416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TEX14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661744CNV Deletion23128226
    esv2671957CNV Deletion23128226
    esv2657166CNV Deletion23128226
    nsv833498CNV Loss17160897
    nsv457863CNV Loss19166990
    nsv515871CNV Loss19592680
    nsv908642CNV Loss21882294
    nsv428347CNV Gain18775914
    dgv994e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): TEX14
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX14
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605792    OMIM disorders: --

    3 diseases for TEX14:    About MalaCards
    azoospermia    pancreatic cancer    pancreatitis


    TEX14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TEX14
    Human Genome Epidemiology (HuGE) Navigator: TEX14 (3 documents)

    Export disorders for TEX14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX14 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TEX14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PubMed id 12711554)1, 2, 3 Wu M.H....Matzuk M.M. (2003)
    2. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
    3. Tex14, a plk1-regulated protein, is required for kinetochore- microtubule attachment and regulation of the spindle assembly checkpoint. (PubMed id 22405274)1, 2 Mondal G.... Couch F.J. (2012)
    4. TEX14 interacts with CEP55 to block cell abscission. (PubMed id 20176808)1, 2 Iwamori T....Matzuk M.M. (2010)
    5. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Association of mitotic regulation pathway polymorphis ms with pancreatic cancer risk and outcome. (PubMed id 20056645)1 Couch F.J....McWilliams R.R. (2010)
    8. Genetic variation in the chromosome 17q23 amplicon an d breast cancer risk. (PubMed id 19454617)4 Kelemen L.E....Couch F.J. (2009)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56155 HGNC: 11737 AceView: TEX14 Ensembl:ENSG00000121101 euGenes: HUgn56155
    ECgene: TEX14 H-InvDB: TEX14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX14 gene:
    Search GeneIP for patents involving TEX14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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