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TEX14 Gene

protein-coding   GIFtS: 50
GCID: GC17M056634

Testis Expressed 14

(Previous name: testis expressed sequence 14)
  Search for TEX14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 141 2     CT1132
Testis Expressed Sequence 141 2     Inactive Serine/Threonine-Protein Kinase TEX142
Cancer/Testis Antigen 1131 2     Testis-Expressed Protein 142
Protein Kinase-Like Protein SgK3072 3     SGK3073
Sugen Kinase 3072 3     Testis-Expressed Sequence 143
Testis-Expressed Sequence 14 Protein2 3     

External Ids:    HGNC: 117371   Entrez Gene: 561552   Ensembl: ENSG000001211017   OMIM: 6057925   UniProtKB: Q8IWB63   

Export aliases for TEX14 gene to outside databases

Previous GC identifers: GC17M056378 GC17M059115 GC17M056976 GC17M057108 GC17M053989 GC17M051994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEX14 Gene:
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for
spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Jan 2011)

GeneCards Summary for TEX14 Gene:
TEX14 (testis expressed 14) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and protein kinase activity.

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule
attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect
differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the
conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55
inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to
transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by
PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has
no protein kinase activity in vitro (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX14 gene promoter:
         SREBP-1c   Tal-1beta   SREBP-1b   E47   SREBP-1a   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX14 promoter sequence
   Search Chromatin IP Primers for TEX14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

TEX14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056634:  view genomic region     (about GC identifiers)

Start:
56,634,038 bp from pter      End:
56,769,416 bp from pter
Size:
135,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6 (See protein sequence)
Recommended Name: Inactive serine/threonine-protein kinase TEX14  
Size: 1497 amino acids; 167901 Da
Subunit: Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and
PDCD6IP/ALIX and TSG101 (By similarity)
Caution: Ser-376 is present instead of the conserved Asp which is expected to be an active site residue
Sequence caution: Sequence=AAK31980.1; Type=Erroneous initiation;
Secondary accessions: A6NH19 Q7RTP3 Q8ND97 Q9BXT9
Alternative splicing: 3 isoforms:  Q8IWB6-1   Q8IWB6-2   Q8IWB6-3   

Explore the universe of human proteins at neXtProt for TEX14: NX_Q8IWB6

Explore proteomics data for TEX14 at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and
    recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid
    depletion from kinetochores and its subsequent degradation by the APC/C complex1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188386.1  NP_112562.3  NP_938207.2  

    ENSEMBL proteins: 
     ENSP00000374584   ENSP00000240361   ENSP00000268910   ENSP00000463593   ENSP00000463243  

    TEX14 Human Recombinant Protein Products:

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    Novus Biologicals TEX14 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TEX14

     
    Search eBioscience for Proteins for TEX14 

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    LSBio Antibodies in human, mouse, rat for TEX14

    TEX14 Assay Products:

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    Search eBioscience for ELISAs for TEX14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis expressed 14
    NKF5 family

    5 InterPro protein domains:
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q8IWB6

    ProtoNet protein and cluster: Q8IWB6

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Domain: The GPPX3Y motif mediates interaction with CEP55
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TEX14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEX14_HUMAN, Q8IWB6
    Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule
    attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect
    differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the
    conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55
    inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to
    transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by
    PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has
    no protein kinase activity in vitro (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with TEX14           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TEX14:
     Decreased DCP1a protein expres  Decreased focal adhesion (FA)   Increased cell death in HCC-19 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tex14):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with TEX14           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tex14tm1Zuk for TEX14

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX14
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEX14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEX14

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    6 qRT-PCR Assays for microRNAs that regulate TEX14:
    hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTEX14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TEX14

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    GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEX14_HUMAN, Q8IWB6: Cytoplasm (By similarity). Midbody (By similarity). Chromosome, centromere, kinetochore (By
    similarity). Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell
    division (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore ISS--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005623cell ISS--
    GO:0005737cytoplasm IEA--
    GO:0030496midbody ISS--

    Find genes that share ontologies with TEX14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX14
    Interactions:

        Search GeneGlobe Interaction Network for TEX14

    1 Interacting protein for TEX14 (Q8IWB61) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ41EBI-6674697,EBI-747776
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007094mitotic spindle assembly checkpoint ISS--
    GO:0007140male meiosis ISS--
    GO:0008608attachment of spindle microtubules to kinetochore ISS--
    GO:0032091negative regulation of protein binding IEA--

    Find genes that share ontologies with TEX14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX14 gene (3 alternative transcripts): 
    NM_001201457.1  NM_031272.4  NM_198393.3  

    Unigene Cluster for TEX14:

    Testis expressed 14
    Hs.390221  [show with all ESTs]
    Unigene Representative Sequence: AL834143
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389934(uc010dcz.2 uc002iwr.2 uc002iws.2) ENST00000584699
    ENST00000240361 ENST00000349033 ENST00000582740(uc010dda.2) ENST00000581147

    miRNA
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    Block miRNA regulation of human, mouse, rat TEX14 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TEX14:
    hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTEX14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TEX14
    Predesigned siRNA for gene silencing in human, mouse, rat TEX14
    Clone
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    OriGene clones in human, mouse for TEX14 (see all 12)
    OriGene ORF clones in mouse, rat for TEX14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEX14
      QuantiTect SYBR Green Assays in human, mouse, rat TEX14
      QuantiFast Probe-based Assays in human, mouse, rat TEX14

    Additional mRNA sequence: 

    AF285601.1 AK125896.1 AK128217.1 AK308299.1 AL834143.1 BC040526.1 BC045647.1 

    8 DOTS entries:

    DT.100020711  DT.101981853  DT.101981854  DT.100020710  DT.103253  DT.97835969  DT.70100320  DT.75160863 

    Selected AceView cDNA sequences (see all 37):

    BM560425 AI291807 BM799864 AW183151 AW663984 BC045647 BK000998 BC040526 
    AF285601 NM_031272 CB529131 AK128217 CB044007 NM_198393 AL834143 AK125896 
    BQ018031 AW505113 AA770308 AI381395 AI025320 AW515647 CB044008 AW183728 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:                    -                                                                                                                                       
    SP2:                                            -     -                                                                                               -         
    SP3:                    -                             -                                                                                               -         
    SP4:                    -                             -                 -     -     -     -     -     -     -                                                   
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                  -                                       
    SP2:                                                  -                                       
    SP3:                                                  -                                       
    SP4:                                                  -                                       
    SP5:  -                                                                                       


    ECgene alternative splicing isoforms for TEX14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACACAGC
    TEX14 Expression
    About this image


    TEX14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
             Primordial germ-like cells
     
     Germ Cells (Reproductive System)
             Primordial germ-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             ES-J1
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
    TEX14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390221

    UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6
    Tissue specificity: Detected in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TEX14 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex141 , 5 testis expressed gene 141, 5 78.27(n)1
    68.54(a)1
      11 (52.09 cM)5
    835601  NM_001199293.11  NP_001186222.11 
     874050655 
    chicken
    (Gallus gallus)
    Aves TEX141 testis expressed 14 55.1(n)
    43.84(a)
      417625  XM_415869.4  XP_415869.4 
    lizard
    (Anolis carolinensis)
    Reptilia TEX146
    testis expressed 14
    65(a)
    1 ↔ 1
    AAWZ02039879(934-6822)
    zebrafish
    (Danio rerio)
    Actinopterygii TEX146
    testis expressed 14
    45(a)
    1 ↔ 1
    10(34376652-34378701) ENSDARG00000090187


    ENSEMBL Gene Tree for TEX14 (if available)
    TreeFam Gene Tree for TEX14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TEX14 gene

    Find genes that share paralogs with TEX14           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TEX14
    PGOHUM00000234292


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX14 (see all 2681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413894
    A gastric adenocarcinoma sample4--see VAR_0413892 K E mis40--------
    rs354487511,2
    C--52069070(+) ACACA-/AATA  
            
    TCTCC
    3 -- int11Minor allele frequency- AATA:0.00NA 2
    rs348575631,2
    C--52095793(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs105654821,2
    C--52104313(+) acggc-/A/AAA 
            
    aaaaa
    3 -- int11NA 2
    rs1510301671,2
    --56633679(+) TTTTTA/GATTTT 3 -- ds50010--------
    rs1859831451,2
    --56633818(+) TGTACG/TTTGAT 3 -- ds50010--------
    rs1173432101,2
    F--56633979(+) TGGGTG/TGCAGT 3 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1176838581,2
    F--56634024(+) ATATAT/CCTTAC 3 -- ds50011Minor allele frequency- C:0.03NA 120
    rs784613541,2
    C--56634321(+) CTTACA/CACCAG 3 -- ut311Minor allele frequency- C:0.01EA 120
    rs2016041251,2
    C--56634365(+) ATCCAA/GTTCCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TEX14 (56634038 - 56769416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TEX14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661744CNV Deletion23128226
    esv2671957CNV Deletion23128226
    esv2657166CNV Deletion23128226
    nsv833498CNV Loss17160897
    nsv457863CNV Loss19166990
    nsv515871CNV Loss19592680
    nsv908642CNV Loss21882294
    nsv428347CNV Gain18775914
    dgv994e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TEX14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX14
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605792    OMIM disorders: --


    Find genes that share disorders with TEX14           About GenesLikeMe

    Genetic Association Database (GAD): TEX14
    Human Genome Epidemiology (HuGE) Navigator: TEX14 (3 documents)

    Export disorders for TEX14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX14 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TEX14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PubMed id 12711554)1, 2, 3 Wu M.-H.... Matzuk M.M. (Gene Expr. Patterns 2003)
    2. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    3. Tex14, a plk1-regulated protein, is required for kinetochore- microtubule attachment and regulation of the spindle assembly checkpoint. (PubMed id 22405274)1, 2 Mondal G.... Couch F.J. (Mol. Cell 2012)
    4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    5. TEX14 interacts with CEP55 to block cell abscission. (PubMed id 20176808)1, 2 Iwamori T....Matzuk M.M. (Mol. Cell. Biol. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Meta-analysis identifies four new loci associated with testicular germ cell tumor. (PubMed id 23666239)1 Chung C.C....Nathanson K.L. (Nat. Genet. 2013)
    8. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)
    9. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. (PubMed id 23666240)1 Ruark E....Turnbull C. (Nat. Genet. 2013)
    10. Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome. (PubMed id 20056645)1 Couch F.J....McWilliams R.R. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56155 HGNC: 11737 AceView: TEX14 Ensembl:ENSG00000121101 euGenes: HUgn56155
    ECgene: TEX14 H-InvDB: TEX14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX14 gene:
    Search GeneIP for patents involving TEX14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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