Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TEX14 Gene

protein-coding GIFtS: 47
GCID: GC17M056634

testis expressed 14

(Previous name: testis expressed sequence 14 )

Explore 3 diseases affiliated with
TEX14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Testis Expressed 14¹ ²		Cancer/Testis Antigen 113²
CT113¹ ²		Inactive Serine/Threonine-Protein Kinase TEX14²
Testis Expressed Sequence 14¹ ²		Testis-Expressed Protein 14²
Protein Kinase-Like Protein SgK307² ³		SGK307³
Sugen Kinase 307² ³		Testis-Expressed Sequence 14³
Testis-Expressed Sequence 14 Protein² ³

External Ids:	HGNC: 11737¹	Entrez Gene: 56155²	Ensembl: ENSG00000121101⁷	OMIM: 605792⁵	UniProtKB: Q8IWB6³

Export aliases for TEX14 gene to outside databases

Previous GC identifers: GC17M056378 GC17M059115 GC17M056976 GC17M057108 GC17M053989 GC17M051994

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEX14:

The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for

spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.(provided by

RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6

Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule

attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating

germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into

intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55

and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges.

Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation

of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TEX14 gene promoter:
SREBP-1c Tal-1beta SREBP-1b E47 SREBP-1a POU2F1 POU2F1a IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEX14 promoter sequence

Search SABiosciences Chromatin IP Primers for TEX14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC chromosome: 17

TEX14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX14 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M056634: view genomic region (about GC identifiers)

Start:	56,634,039 bp from pter	End:	56,769,416 bp from pter
Size:	135,378 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6 (See protein sequence)

Recommended Name: Inactive serine/threonine-protein kinase TEX14

Size: 1497 amino acids; 167901 Da

Subunit: Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX

and TSG101 (By similarity)

Subcellular location: Cytoplasm (By similarity). Midbody (By similarity). Chromosome, centromere, kinetochore (By

similarity). Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division

(By similarity)

Caution: Ser-376 is present instead of the conserved Asp which is expected to be an active site residue

Sequence caution: Sequence=AAK31980.1; Type=Erroneous initiation;

Secondary accessions: A6NH19 Q7RTP3 Q8ND97 Q9BXT9

Alternative splicing: 3 isoforms: Q8IWB6-1 Q8IWB6-2 Q8IWB6-3

Explore the universe of human proteins at neXtProt for TEX14: NX_Q8IWB6

Post-translational modifications:

Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and

recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion

from kinetochores and its subsequent degradation by the APC/C complex¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWB6

TEX14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001188386.1 NP_112562.3 NP_938207.2

ENSEMBL proteins:

ENSP00000374584 ENSP00000240361 ENSP00000268910 ENSP00000463593 ENSP00000463243

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TEX14 OriGene Custom Protein Services for TEX14
	GenScript Custom Purified and Recombinant Proteins Services for TEX14
	Novus Biologicals TEX14 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TEX14

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	ISS	--
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0005623	cell	ISS	--
GO:0005737	cytoplasm	IEA	--
GO:0030496	midbody	ISS	--

TEX14 for ontologies About GeneDecksing

TEX14 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TEX14
	GenScript Custom Superior Antibodies Services for TEX14
	Novus Biologicals TEX14 Antibodies
	Search for Antibodies for TEX14 at Abcam
	Uscn Antibodies for TEX14
	Search ThermoFisher Antibodies for TEX14

Assay Products for TEX14:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TEX14
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TEX14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TEX14 for domains About GeneDecksing

5 InterPro domains/families:

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8IWB6

ProtoNet protein and cluster: Q8IWB6

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6

Domain: The protein kinase domain is predicted to be catalytically inactive

Domain: The GPPX3Y motif mediates interaction with CEP55

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 3 ANK repeats

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6

Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule

attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating

germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into

intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55

and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges.

Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation

of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TEX14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX14
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX14:
		hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
		SwitchGear 3'UTR luciferase reporter plasmid: TEX14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEX14 (see all 4) OriGene shRNA RFP: TEX14 OriGene siRNA: TEX14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX14

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TEX14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TEX14
		Search LifeMap BioReagents cell lines for TEX14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0019901	protein kinase binding	IPI	--

TEX14 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for TEX14:

Decreased DCP1a protein expres

Decreased focal adhesion (FA)

Increased cell death in HCC-19

Animal Models:
Mouse knock-out Tex14^tm1Zuk for TEX14
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tex14):

endocrine/exocrine gland

reproductive system

TEX14 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TEX14

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007094	mitotic cell cycle spindle assembly checkpoint	ISS	--
GO:0007140	male meiosis	ISS	--
GO:0008608	attachment of spindle microtubules to kinetochore	ISS	--
GO:0032091	negative regulation of protein binding	IEA	--
GO:0032466	negative regulation of cytokinesis	IEA	--

TEX14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TEX14
Search CenterWatch for drugs/clinical trials and news about TEX14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TEX14 gene (3 alternative transcripts):

NM_001201457.1 NM_031272.4 NM_198393.3

Unigene Cluster for TEX14:

Testis expressed 14

Hs.390221 [show with all ESTs]

Unigene Representative Sequence: AL834143

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389934(uc010dcz.2 uc002iwr.2 uc002iws.2) ENST00000584699

ENST00000240361 ENST00000349033 ENST00000582740(uc010dda.2) ENST00000581147

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TEX14 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX14
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TEX14:
		hsa-miR-640 hsa-miR-1323 hsa-miR-561 hsa-miR-3065-5p hsa-miR-548o hsa-miR-410
		SwitchGear 3'UTR luciferase reporter plasmid: TEX14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEX14 (see all 4) OriGene shRNA RFP: TEX14 OriGene siRNA: TEX14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX14

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TEX14 (NM_031272)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEX14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEX14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TEX14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEX14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX14

Additional cDNA sequence:

AF285601.1 AK125896.1 AK128217.1 AK308299.1 AL834143.1 BC040526.1 BC045647.1

8 DOTS entries:

DT.100020711 DT.101981853 DT.101981854 DT.100020710 DT.103253 DT.97835969 DT.70100320 DT.75160863

24/37 AceView cDNA sequences (see all 37):

NM_031272 AW663984 AI291807 BC040526 BC045647 AK125896 CB044007 NM_198393

AW183151 BK000998 BM799864 AL834143 CB529131 AF285601 AK128217 BM560425

BX109653 AW183728 AW515647 AL040739 AI381395 AL040738 AI025320 CB044008

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·
SP1:							-
SP2:															-		-																																-
SP3:							-										-																																-
SP4:							-										-						-		-		-		-		-		-		-
SP5:

ExUns:	22b	^	23	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35
SP1:																	-
SP2:																	-
SP3:																	-
SP4:																	-
SP5:	-

ECgene alternative splicing isoforms for TEX14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TEX14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACACAGC

About this image

TEX14 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Primary Spermatocyte

Germ Cells, Male Gametocytes

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

FES22 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

FES29 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

ES-J1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Primordial germ-like cells (Derivation of embryo...)

Embryoid bodies (Derivation of embryo...)

Short-term differentiated embryoid bodies (Derivation of embryo...)

See TEX14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TEX14

SOURCE GeneReport for Unigene cluster: Hs.390221

UniProtKB/Swiss-Prot: TEX14_HUMAN, Q8IWB6

Tissue specificity: Detected in testis

SABiosciences Custom PCR Arrays for TEX14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEX14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TEX14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEX14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TEX14 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tex14^{1 , 5}	testis expressed gene 14^{1, 5}	78.41(n)¹ 68.54(a)¹		11 (52.09 cM)⁵ 83560¹ NM_001199293.1¹ NP_001186222.1¹ 87405065⁵
chicken (Gallus gallus)	Aves	TEX14¹	testis expressed 14	57.59(n) 47.61(a)		417625 XM_415869.3 XP_415869.3
lizard (Anolis carolinensis)	Reptilia	TEX14⁶ TEX14⁶	--	68(a) 41(a)	1 ↔ 1 possible ortholog	AAWZ02039879(1080-6799) 2(191844547-191855957)
zebrafish (Danio rerio)	Actinopterygii	BX088525.3⁶	--	47(a)	1 ↔ 1	10(34376652-34378701)
honey bee (Apis mellifera)	Insecta	-- -- (see all 3)	--	21(a) 13(a) (see all 3)	many → 1 many → 1 (see all 3)	Group16.2(124119-128421) Group16.2(121438-137011)

ENSEMBL Gene Tree for TEX14 (if available)
TreeFam Gene Tree for TEX14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TEX14 gene

TEX14 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TEX14
PGOHUM00000234292

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151030167^1,2		--	56633679(+)	`TTTTTA/GATTTT`	3	--	ds500¹		0	--	--	--	--
rs185983145^1,2		--	56633818(+)	`TGTACG/TTTGAT`	3	--	ds500¹		0	--	--	--	--
rs117343210^1,2		--	56633979(+)	`TGGGTG/TGCAGT`	3	--	ds500¹		1		NA	120
rs117683858^1,2	F,	--	56634024(+)	`ATATAT/CCTTAC`	3	--	ds500¹		1		NA	120
rs78461354^1,2	C,	--	56634321(+)	`CTTACA/CACCAG`	3	--	ut3¹		1		EA	120
rs201604125^1,2		--	56634365(+)	`ATCCAA/GTTCCA`	3	--	ut3¹		0	--	--	--	--
rs140007510^1,2		--	56634566(+)	`TGTCAC/TGGAAA`	3	--	int¹		0	--	--	--	--
rs201002857^1,2	C	--	56634600(+)	`GACAGC/TAGCAT`	3	--	int¹		0	--	--	--	--
rs59283518^1,2	C	--	56634637(+)	`TTTTT-/TGAGAC`	3	--	int¹		0	--	--	--	--
rs149842200^1,2		--	56634652(+)	`TTTGAA/GACGGA`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TEX14 (56634039 - 56769416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TEX14
2 CNVs: 4042 49902
1 Indel: 49901
Human Gene Mutation Database (HGMD): TEX14

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEX14

DNA2.0 Custom Variant and Variant Library Synthesis for TEX14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TEX14 for disorders           About GeneDecksing

OMIM gene information: 605792    OMIM disorders: --

3 diseases for TEX14:    About MalaCards

azoospermia pancreatic cancer pancreatitis

Human Genome Epidemiology (HuGE) Navigator: TEX14 (3 documents)

Export disorders for TEX14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TEX14 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TEX14)

Utopia: connect your pdf to the dynamic
world of online information

Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PubMed id 12711554)^{1, 2, 3} Wu M.H....Matzuk M.M. (2003)
An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)^{1, 2, 3} Wang P.J.... Page D.C. (2001)
Tex14, a plk1-regulated protein, is required for kinetochore- microtubule attachment and regulation of the spindle assembly checkpoint. (PubMed id 22405274)^{1, 2} Mondal G.... Couch F.J. (2012)
TEX14 interacts with CEP55 to block cell abscission. (PubMed id 20176808)^{1, 2} Iwamori T....Matzuk M.M. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of mitotic regulation pathway polymorphis ms with pancreatic cancer risk and outcome. (PubMed id 20056645)¹ Couch F.J....McWilliams R.R. (2010)
Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)¹ Aston K.I....Carrell D.T. (2010)
Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56155	HGNC: 11737	AceView: TEX14	Ensembl:ENSG00000121101	euGenes: HUgn56155
ECgene: TEX14	H-InvDB: TEX14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TEX14	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TEX14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TEX14 gene:
Search GeneIP for patents involving TEX14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TEX14
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEX14		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEX14
	OriGene Protein Over-expression Lysate for TEX14		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TEX14		OriGene 3'-UTR Clone for TEX14
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEX14
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TEX14		OriGene Custom Protein Services for TEX14
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEX14
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEX14
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX14
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEX14
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX14
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEX14

	GenScript Custom Purified and Recombinant Proteins Services for TEX14		GenScript cDNA clones with any tag delivered in your preferred vector for TEX14
	GenScript Custom Assay Services for TEX14		GenScript Custom Superior Antibodies Services for TEX14
	GenScript Custom overexpressing Cell Line Services for TEX14		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TEX14 promoter
	Search Chromatin IP Primers for TEX14
	RT² qPCR Primer Assay in human, mouse, rat TEX14
	Search GNC Networks for TEX14
	SABiosciences Custom PCR Arrays for TEX14

Search Tocris compounds for TEX14

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TEX14 antibodies
	TEX14 proteins

	Search for Antibodies for TEX14 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TEX14
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TEX14 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TEX14

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX14

	SwitchGear 3'UTR luciferase reporter plasmids for TEX14
	SwitchGear Promoter luciferase reporter plasmids for TEX14

Search ThermoFisher Antibodies for TEX14

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX14

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TEX14 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TEX14 Gene

testis expressed 14

Aliases
for TEX14 gene

Summaries
for TEX14 gene

Genomic Views
for TEX14 gene

Proteins
for TEX14 gene

Protein Domains /
Families
for TEX14 gene

Function
for TEX14 gene

Pathways & Interactions
for TEX14 gene

Drugs & Compounds
for TEX14 gene

Transcripts
for TEX14 gene

Expression
for TEX14 gene

Orthologs
for TEX14 gene

Paralogs
for TEX14 gene

Genomic Variants
for TEX14 gene

Disorders / Diseases
for TEX14 gene

Publications
for TEX14 gene

External Searches for TEX14 gene

Genome Databases showing TEX14 gene

Other Databases showing TEX14 gene

Specialized Databases showing TEX14 gene

Intellectual Property
for TEX14 gene

Products
for TEX14 gene

View Random Gene

Advanced Search

Export list of displayed genes

TEX14 Gene

testis expressed 14

Aliasesfor TEX14 gene

Summariesfor TEX14 gene

Genomic Viewsfor TEX14 gene

Proteinsfor TEX14 gene

Protein Domains /Familiesfor TEX14 gene

Functionfor TEX14 gene

Pathways & Interactionsfor TEX14 gene

Drugs & Compoundsfor TEX14 gene

Transcriptsfor TEX14 gene

Expression for TEX14 gene

Orthologsfor TEX14 gene

Paralogsfor TEX14 gene

Genomic Variantsfor TEX14 gene

Disorders / Diseasesfor TEX14 gene

Publicationsfor TEX14 gene

External Searches for TEX14 gene

Genome Databases showing TEX14 gene

Other Databases showing TEX14 gene

Specialized Databases showing TEX14 gene

Intellectual Propertyfor TEX14 gene

Productsfor TEX14 gene

View Random Gene

Aliases
for TEX14 gene

Summaries
for TEX14 gene

Genomic Views
for TEX14 gene

Proteins
for TEX14 gene

Protein Domains /
Families
for TEX14 gene

Function
for TEX14 gene

Pathways & Interactions
for TEX14 gene

Drugs & Compounds
for TEX14 gene

Transcripts
for TEX14 gene

Expression
for TEX14 gene

Orthologs
for TEX14 gene

Paralogs
for TEX14 gene

Genomic Variants
for TEX14 gene

Disorders / Diseases
for TEX14 gene

Publications
for TEX14 gene

Intellectual Property
for TEX14 gene

Products
for TEX14 gene