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TEX13B Gene

protein-coding   GIFtS: 45
GCID: GC0XM107224

Testis Expressed 13B

(Previous name: testis expressed sequence 13B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 13B1 2
Testis Expressed Sequence 13B1 2
TGC3B2
TSGA52
Testis-Expressed Sequence 13B Protein2

External Ids:    HGNC: 117361   Entrez Gene: 561562   Ensembl: ENSG000001709257   OMIM: 3003135   UniProtKB: Q9BXU23   

Export aliases for TEX13B gene to outside databases

Previous GC identifers: GC0XM102631 GC0XM104143 GC0XM105257 GC0XM105995 GC0XM107030 GC0XM107110 GC0XM096847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEX13B Gene:
This gene is similar to a mouse gene that is expressed in the testis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEX13B Gene:
TEX13B (testis expressed 13B) is a protein-coding gene. Diseases associated with TEX13B include azoospermia, and retinitis. An important paralog of this gene is TEX13A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX13B gene promoter:
         ER-alpha   GR   STAT5B   RelA   NF-kappaB   Evi-1   C/EBPalpha   GR-alpha   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX13B promoter sequence
   Search Chromatin IP Primers for TEX13B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq23

TEX13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX13B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM107224:  view genomic region     (about GC identifiers)

Start:
107,224,094 bp from pter      End:
107,225,600 bp from pter
Size:
1,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TX13B_HUMAN, Q9BXU2 (See protein sequence)
Recommended Name: Testis-expressed sequence 13B protein  
Size: 312 amino acids; 33967 Da
Secondary accessions: Q5JYF6

Explore the universe of human proteins at neXtProt for TEX13B: NX_Q9BXU2

Explore proteomics data for TEX13B at MOPED


See TEX13B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_112563.1  
ENSEMBL proteins: 
 ENSP00000303777  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028193 TEX13

Graphical View of Domain Structure for InterPro Entry Q9BXU2

ProtoNet protein and cluster: Q9BXU2


TEX13B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for TEX13B:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX13B
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miRNA
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miRTarBase miRNAs that target TEX13B:
hsa-mir-335-5p (MIRT017579)

Block miRNA regulation of human, mouse, rat TEX13B using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate TEX13B:
hsa-miR-188-3p hsa-miR-942 hsa-miR-532-3p
SwitchGear 3'UTR luciferase reporter plasmidTEX13B 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
mitochondrion1
nucleus1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX13B
Interactions:

    Search GeneGlobe Interaction Network for TEX13B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TEX13B (TX13B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TEX13B gene: 
NM_031273.2  

Unigene Cluster for TEX13B:

Testis expressed 13B
Hs.333130
Unigene Representative Sequence: BC150140
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000302917(uc004enn.1)
miRNA
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hsa-miR-188-3p hsa-miR-942 hsa-miR-532-3p
SwitchGear 3'UTR luciferase reporter plasmidTEX13B 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat TEX13B

Additional mRNA sequence: 

AF285598.1 BC150140.1 

1 DOTS entry:

DT.95307489 

2 AceView cDNA sequences:

NM_031273 AF285598 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEX13B expression in normal human tissues (normalized intensities)      TEX13B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGGAAAAT
TEX13B Expression
About this image


TEX13B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Gonad
         XY Germ Cells Testis Cord
 
 Ovary (Reproductive System)
         XX Germ Cells Ovigerous Cord
 
 Testis (Reproductive System)
         XY Germ Cells Testis Cord
 
 Eye (Sensory Organs)
         Retina
TEX13B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TEX13B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.333130

UniProtKB/Swiss-Prot: TX13B_HUMAN, Q9BXU2
Tissue specificity: Testis specific

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX13B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TEX13B gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tex131 , 5 testis expressed gene 131, 5 72.41(n)1
62.91(a)1
  X (61.50 cM)5
835551  NM_031381.21  NP_113558.11 
 1408083075 


ENSEMBL Gene Tree for TEX13B (if available)
TreeFam Gene Tree for TEX13B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TEX13B gene
TEX13A2  
1 SIMAP similar gene for TEX13B using alignment to 1 protein entry:     TX13B_HUMAN:
TEX13A

TEX13B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TEX13B (see all 79)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1501018231,2
--96847130(+) TCTAAC/TGTAAA 1 -- ds50010--------
rs1854943161,2
--96847559(+) GATTCA/GCCTCC 1 -- ut310--------
rs1892049051,2
--96847614(+) CACCAC/TGGGCA 1 -- ut310--------
rs2004858701,2
C--96847753(+) CAGAGC/GCCCCC 2 G syn10--------
rs413008881,2
C--96847978(+) GCCCCA/GCAAAG 2 C syn10--------
rs1487509111,2
C,F--96848009(+) TAGCTC/TCGAGG 2 E G mis11Minor allele frequency- T:0.00NA 4548
rs1423955051,2
C,F--96848010(+) AGCTCC/G/TGAGGG 3 R G mis11NA 4548
rs413008721,2
C,F--96848097(+) TTTTCC/TTCCAG 2 R G mis14Minor allele frequency- T:0.11NA NS CSA 4439
rs2010614541,2
C--96848123(+) CCACCA/GCCTCC 2 A V mis10--------
rs454920001,2
C--96848153(+) CTTCTA/GTCCAA 2 T I mis10--------

HapMap Linkage Disequilibrium report for TEX13B (107224094 - 107225600 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TEX13B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525651CNV Gain19592680

Human Gene Mutation Database (HGMD): TEX13B
Locus Specific Mutation Databases (LSDB): TEX13B

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300313    OMIM disorders: --

2 diseases for TEX13B:    About MalaCards
azoospermia    retinitis


TEX13B for disorders           About GeneDecksing


Export disorders for TEX13B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TEX13B gene integrated from 10 sources:
(articles sorted by number of sources associating them with TEX13B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  3. Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation. (PubMed id 14531651)1 Lee S....Cha K.Y. (J. Assist. Reprod. Genet. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56156 HGNC: 11736 AceView: TEX13B Ensembl:ENSG00000170925 euGenes: HUgn56156
ECgene: TEX13B H-InvDB: TEX13B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TEX13B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TEX13B gene:
Search GeneIP for patents involving TEX13B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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