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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX13B Gene

protein-coding   GIFtS: 44
GCID: GC0XM107224

Testis Expressed 13B

(Previous name: testis expressed sequence 13B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Expressed 13B1 2
Testis Expressed Sequence 13B1 2
TGC3B2
TSGA52
Testis-Expressed Sequence 13B Protein2

External Ids:    HGNC: 117361   Entrez Gene: 561562   Ensembl: ENSG000001709257   OMIM: 3003135   UniProtKB: Q9BXU23   

Export aliases for TEX13B gene to outside databases

Previous GC identifers: GC0XM102631 GC0XM104143 GC0XM105257 GC0XM105995 GC0XM107030 GC0XM107110 GC0XM096847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEX13B Gene:
This gene is similar to a mouse gene that is expressed in the testis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEX13B Gene: 
TEX13B (testis expressed 13B) is a protein-coding gene. Diseases associated with TEX13B include azoospermia. An important paralog of this gene is TEX13A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX13B gene promoter:
         ER-alpha   GR   STAT5B   RelA   NF-kappaB   Evi-1   C/EBPalpha   GR-alpha   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX13B promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX13B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq23

TEX13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX13B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM107224:  view genomic region     (about GC identifiers)

Start:
107,224,094 bp from pter      End:
107,225,600 bp from pter
Size:
1,507 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TX13B_HUMAN, Q9BXU2 (See protein sequence)
Recommended Name: Testis-expressed sequence 13B protein  
Size: 312 amino acids; 33967 Da
Secondary accessions: Q5JYF6

Explore the universe of human proteins at neXtProt for TEX13B: NX_Q9BXU2

Explore proteomics data for TEX13B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXU2

  • TEX13B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEX13B Protein Expression
    REFSEQ proteins: NP_112563.1  
    ENSEMBL proteins: 
     ENSP00000303777  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BXU2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TEX13B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX13B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX13B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX13B (TX13B)

    Search CenterWatch for drugs/clinical trials and news about TEX13B / TX13B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX13B gene: 
    NM_031273.2  

    Unigene Cluster for TEX13B:

    Testis expressed 13B
    Hs.333130
    Unigene Representative Sequence: BC150140
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302917(uc004enn.1)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX13B

    Additional mRNA sequence: 

    AF285598.1 BC150140.1 

    1 DOTS entry:

    DT.95307489 

    2 AceView cDNA sequences:

    AF285598 NM_031273 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX13B expression in normal human tissues (normalized intensities)      TEX13B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGAAAAT
    TEX13B Expression
    About this image


    TEX13B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord

    See TEX13B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX13B

    SOURCE GeneReport for Unigene cluster: Hs.333130

    UniProtKB/Swiss-Prot: TX13B_HUMAN, Q9BXU2
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX13B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TEX13B gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex131 , 5 testis expressed gene 131, 5 72.41(n)1
    62.91(a)1
      X (61.50 cM)5
    835551  NM_031381.21  NP_113558.11 
     1408083075 


    ENSEMBL Gene Tree for TEX13B (if available)
    TreeFam Gene Tree for TEX13B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEX13B gene
    TEX13A2  
    1 SIMAP similar gene for TEX13B using alignment to 1 protein entry:     TX13B_HUMAN:
    TEX13A

    TEX13B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 SNPs in TEX13B are shown (see all 79)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501018231,2
    --96847130(+) TCTAAC/TGTAAA 1 -- ds50010--------
    rs1854943161,2
    --96847559(+) GATTCA/GCCTCC 1 -- ut310--------
    rs1892049051,2
    --96847614(+) CACCAC/TGGGCA 1 -- ut310--------
    rs2004858701,2
    C--96847753(+) CAGAGC/GCCCCC 2 G syn10--------
    rs413008881,2
    C--96847978(+) GCCCCA/GCAAAG 2 C syn10--------
    rs1487509111,2
    C,F--96848009(+) TAGCTC/TCGAGG 2 E G mis11Minor allele frequency- T:0.00NA 4548
    rs1423955051,2
    C,F--96848010(+) AGCTCC/G/TGAGGG 3 R G mis11NA 4548
    rs413008721,2
    C,F--96848097(+) TTTTCC/TTCCAG 2 R G mis14Minor allele frequency- T:0.11NA NS CSA 4439
    rs2010614541,2
    C--96848123(+) CCACCA/GCCTCC 2 A V mis10--------
    rs454920001,2
    C--96848153(+) CTTCTA/GTCCAA 2 T I mis10--------

    HapMap Linkage Disequilibrium report for TEX13B (107224094 - 107225600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TEX13B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525651CNV Gain19592680


    Human Gene Mutation Database (HGMD): TEX13B

    Locus Specific Mutation Databases (LSDB): TEX13B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300313    OMIM disorders: --

    2 diseases for TEX13B:    About MalaCards
    azoospermia    


    TEX13B for disorders           About GeneDecksing


    Export disorders for TEX13B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX13B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEX13B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation. (PubMed id 14531651)1 Lee S....Cha K.Y. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56156 HGNC: 11736 AceView: TEX13B Ensembl:ENSG00000170925 euGenes: HUgn56156
    ECgene: TEX13B H-InvDB: TEX13B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX13B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX13B gene:
    Search GeneIP for patents involving TEX13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     ELISAs for TEX13B
     CLIAs for TEX13B
     Search LifeMap BioReagents cell lines for TEX13B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX13B
     SwitchGear 3'UTR luciferase reporter plasmids for TEX13B
     SwitchGear Promoter luciferase reporter plasmids for TEX13B
     ThermoFisher Antibody for TEX13B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX13B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TEX13B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TEX13B
    Customized:
     lentivirus for stable overexpression of TEX13B
     lentivirus expression plasmids for stable overexpression of TEX13B
     adenovirus for overexpression of TEX13B
     LSBio Antibodies in human, mouse, rat for TEX13B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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