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TEX13A Gene

protein-coding   GIFtS: 43
GCID: GC0XM104463

Testis Expressed 13A

(Previous name: testis expressed sequence 13A)
  Search for TEX13A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 13A1 2
Testis Expressed Sequence 13A1
Testis-Expressed Sequence 13A Protein2

External Ids:    HGNC: 117351   Entrez Gene: 561572   Ensembl: ENSG000001331497   OMIM: 3003125   UniProtKB: Q9BXU33   

Export aliases for TEX13A gene to outside databases

Previous GC identifers: GC0XM099775 GC0XM101382 GC0XM102496 GC0XM103235 GC0XM104269 GC0XM094089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEX13A Gene:
This gene is similar to a mouse gene that is expressed in the testis. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for TEX13A Gene:
TEX13A (testis expressed 13A) is a protein-coding gene. An important paralog of this gene is TEX13B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX13A gene promoter:
         Sox5   LCR-F1   GATA-1   HNF-1A   MEF-2A   CP2   HNF-1   Cart-1   aMEF-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX13A promoter sequence
   Search Chromatin IP Primers for TEX13A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX13A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq28

TEX13A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX13A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM104463:  view genomic region     (about GC identifiers)

Start:
104,463,611 bp from pter      End:
104,465,358 bp from pter
Size:
1,748 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TX13A_HUMAN, Q9BXU3 (See protein sequence)
Recommended Name: Testis-expressed sequence 13A protein  
Size: 409 amino acids; 45583 Da
Sequence caution: Sequence=CAI41996.1; Type=Erroneous gene model prediction;
Secondary accessions: B1B1G8 Q32NB6

Explore the universe of human proteins at neXtProt for TEX13A: NX_Q9BXU3

Explore proteomics data for TEX13A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX13A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001278206.1  NP_112564.1  

    ENSEMBL proteins: 
     ENSP00000361659   ENSP00000361656   ENSP00000399753  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001876 Znf_RanBP2
     IPR028193 TEX13

    Graphical View of Domain Structure for InterPro Entry Q9BXU3

    ProtoNet protein and cluster: Q9BXU3

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: TX13A_HUMAN, Q9BXU3
    Similarity: Contains 1 RanBP2-type zinc finger


    Find genes that share domains with TEX13A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with TEX13A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX13A
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    hsa-mir-148b-3p (MIRT019268)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX13A
    Interactions:

        Search GeneGlobe Interaction Network for TEX13A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TEX13A (ENSP000003997534) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDXACB1ENSP000002602574STRING: ENSP00000260257
    SRSF4ENSP000003629004STRING: ENSP00000362900
    SRSF5ENSP000003778924STRING: ENSP00000377892
    SRSF6ENSP000002440204STRING: ENSP00000244020
    PDSS1ENSP000003653884STRING: ENSP00000365388
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX13A (TX13A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX13A gene (2 alternative transcripts): 
    NM_001291277.1  NM_031274.4  

    Unigene Cluster for TEX13A:

    Testis expressed 13A
    Hs.567543  [show with all ESTs]
    Unigene Representative Sequence: BC042547
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372578(uc004ema.3 uc004emb.3) ENST00000372575 ENST00000413579

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      QuantiTect SYBR Green Assays in human, mouse, rat TEX13A
      QuantiFast Probe-based Assays in human, mouse, rat TEX13A

    Additional mRNA sequence: 

    AF285597.1 BC042547.1 BC108734.1 

    3 DOTS entries:

    DT.95142259  DT.95094757  DT.404650 

    10 AceView cDNA sequences:

    BX281602 BI825424 BC042547 AA406159 AF285597 AW451397 NM_031274 AI918728 
    AA406158 BM560315 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX13A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TEX13A Expression
    About this image


    TEX13A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    TEX13A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX13A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567543

    UniProtKB/Swiss-Prot: TX13A_HUMAN, Q9BXU3
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX13A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TEX13A gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex13a1 , 5 testis expressed 13A1, 5 65.32(n)1
    53.69(a)1
      X (60.22 cM)5
    679441  NM_026469.21  NP_080745.21 
     1382081655 


    ENSEMBL Gene Tree for TEX13A (if available)
    TreeFam Gene Tree for TEX13A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEX13A gene
    TEX13B2  
    1 SIMAP similar gene for TEX13A using alignment to 2 protein entries:     TX13A_HUMAN (see all proteins):
    TEX13B

    Find genes that share paralogs with TEX13A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TEX13A
    PGOHUM00000260979 PGOHUM00000260980


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Locus Specific Mutation Databases (LSDB): TEX13A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEX13A
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX13A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300312    OMIM disorders: --


    Find genes that share disorders with TEX13A           About GenesLikeMe


    Export disorders for TEX13A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX13A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEX13A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation. (PubMed id 14531651)1 Lee S....Cha K.Y. (J. Assist. Reprod. Genet. 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56157 HGNC: 11735 AceView: TEX13A Ensembl:ENSG00000133149 euGenes: HUgn56157
    ECgene: TEX13A H-InvDB: TEX13A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEX13A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEX13A gene:
    Search GeneIP for patents involving TEX13A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     SwitchGear Promoter luciferase reporter plasmids for TEX13A
     ThermoFisher Antibodies for TEX13A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEX13A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX13A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEX13A
     LSBio Antibodies in human, mouse, rat for TEX13A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TEX13A
      Search eBioscience for proteins for TEX13A
      Search eBioscience for elisas for TEX13A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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