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Aliases for TEX11 Gene

Aliases for TEX11 Gene

  • Testis Expressed 11 2 3
  • Testis Expressed Sequence 11 2 3
  • Testis-Expressed Sequence 11 Protein 3
  • TSGA3 3
  • TGC1 3

External Ids for TEX11 Gene

Summaries for TEX11 Gene

Entrez Gene Summary for TEX11 Gene

  • This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX11 Gene

TEX11 (Testis Expressed 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TEX11 Gene

  • Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX11 Gene

Genomics for TEX11 Gene

Genomic Location for TEX11 Gene

Start:
70,528,940 bp from pter
End:
70,908,731 bp from pter
Size:
379,792 bases
Orientation:
Minus strand

Genomic View for TEX11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX11 Gene

Regulatory Elements for TEX11 Gene

Proteins for TEX11 Gene

  • Protein details for TEX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF3-TEX11_HUMAN
    Recommended name:
    Testis-expressed sequence 11 protein
    Protein Accession:
    Q8IYF3
    Secondary Accessions:
    • A8K8V6
    • Q5JQQ8
    • Q96LZ4
    • Q96M47
    • Q9BXU6

    Protein attributes for TEX11 Gene

    Size:
    940 amino acids
    Molecular mass:
    107889 Da
    Quaternary structure:
    • Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
    SequenceCaution:
    • Sequence=AAK31973.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39958.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI40155.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX11 Gene

Proteomics data for TEX11 Gene at MOPED

Post-translational modifications for TEX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX11 Gene

No data available for DME Specific Peptides for TEX11 Gene

Domains for TEX11 Gene

Protein Domains for TEX11 Gene

UniProtKB/Swiss-Prot:

TEX11_HUMAN
Family:
  • Belongs to the SPO22 family.:
    • Q8IYF3
genes like me logo Genes that share domains with TEX11: view

No data available for Gene Families for TEX11 Gene

Function for TEX11 Gene

Molecular function for TEX11 Gene

UniProtKB/Swiss-Prot Function: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

Gene Ontology (GO) - Molecular Function for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEX11: view

Phenotypes for TEX11 Gene

genes like me logo Genes that share phenotypes with TEX11: view

Animal Models for TEX11 Gene

MGI Knock Outs for TEX11:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TEX11 Gene

Localization for TEX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX11 Gene

Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX11 Gene COMPARTMENTS Subcellular localization image for TEX11 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome --
GO:0000795 colocalizes_with synaptonemal complex ISS --
GO:0000801 central element IEA --
genes like me logo Genes that share ontologies with TEX11: view

Pathways for TEX11 Gene

SuperPathways for TEX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IEA --
GO:0006311 meiotic gene conversion ISS --
GO:0007060 male meiosis chromosome segregation IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007131 reciprocal meiotic recombination ISS --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Pathways by source for TEX11 Gene

Transcripts for TEX11 Gene

mRNA/cDNA for TEX11 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX11 Gene

Testis expressed 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEX11 Gene

No ASD Table

Relevant External Links for TEX11 Gene

GeneLoc Exon Structure for
TEX11
ECgene alternative splicing isoforms for
TEX11

Expression for TEX11 Gene

mRNA expression in normal human tissues for TEX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX11 Gene

This gene is overexpressed in Testis (25.0) and Pancreas (21.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEX11 Gene

SOURCE GeneReport for Unigene cluster for TEX11 Gene Hs.121776

mRNA Expression by UniProt/SwissProt for TEX11 Gene

Q8IYF3-TEX11_HUMAN
Tissue specificity: Testis-specific. Not expressed in adult ovaries.
genes like me logo Genes that share expressions with TEX11: view

Orthologs for TEX11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX11 36
  • 99.1 (n)
  • 98.05 (a)
TEX11 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEX11 36
  • 79.79 (n)
  • 65.1 (a)
TEX11 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEX11 36
  • 84.46 (n)
  • 73.47 (a)
TEX11 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tex11 36
  • 74.23 (n)
  • 56.26 (a)
Tex11 16
Tex11 37
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEX11 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex11 36
  • 73.67 (n)
  • 56.44 (a)
chicken
(Gallus gallus)
Aves TEX11 36
  • 63 (n)
  • 53.09 (a)
TEX11 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEX11 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tex11 36
  • 56.74 (n)
  • 48.71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC797197 36
  • 56.16 (n)
  • 47.84 (a)
TEX11 37
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToOne
Species with no ortholog for TEX11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX11 Gene

ENSEMBL:
Gene Tree for TEX11 (if available)
TreeFam:
Gene Tree for TEX11 (if available)

Paralogs for TEX11 Gene

No data available for Paralogs for TEX11 Gene

Variants for TEX11 Gene

Sequence variations from dbSNP and Humsavar for TEX11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs719345 -- 70,669,333(-) CAATC(A/G)CAGAG intron-variant
rs942667 -- 70,559,219(+) gcaat(A/G)gaata intron-variant
rs1005860 -- 70,575,438(-) gtaac(A/C)ctgtt intron-variant
rs1317383 -- 70,610,896(+) TTCAA(A/G)TAAAG intron-variant
rs1325082 -- 70,589,648(-) CTACT(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv517078 CNV Gain 19592680
nsv510931 CNV Complex 20534489
esv2740210 CNV Deletion 23290073
nsv507968 CNV Insertion 20534489
nsv425085 CNV Loss 16902084
esv1629284 CNV Insertion 17803354
esv2740211 CNV Deletion 23290073
esv2667978 CNV Deletion 23128226

Relevant External Links for TEX11 Gene

HapMap Linkage Disequilibrium report
TEX11
Locus Specific Mutation Databases (LSDB)
TEX11

Disorders for TEX11 Gene

(1) University of Copenhagen DISEASES for TEX11 Gene

Relevant External Links for TEX11

Genetic Association Database (GAD)
TEX11
Human Genome Epidemiology (HuGE) Navigator
TEX11
genes like me logo Genes that share disorders with TEX11: view

No data available for UniProtKB/Swiss-Prot for TEX11 Gene

Publications for TEX11 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 49
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TEX11 Gene

Sources for TEX11 Gene

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