Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEX11 Gene

Aliases for TEX11 Gene

  • Testis Expressed 11 2 3 5
  • Testis Expressed Sequence 11 2 3
  • Testis-Expressed Sequence 11 Protein 3
  • SPGFX2 3
  • TSGA3 3
  • TGC1 3

External Ids for TEX11 Gene

Previous GeneCards Identifiers for TEX11 Gene

  • GC0XM065926
  • GC0XM067226
  • GC0XM067982
  • GC0XM068615
  • GC0XM069531
  • GC0XM069665
  • GC0XM069748
  • GC0XM063570

Summaries for TEX11 Gene

Entrez Gene Summary for TEX11 Gene

  • This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX11 Gene

TEX11 (Testis Expressed 11) is a Protein Coding gene. Diseases associated with TEX11 include Spermatogenic Failure, X-Linked, 2 and Azoospermia.

UniProtKB/Swiss-Prot for TEX11 Gene

  • Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX11 Gene

Genomics for TEX11 Gene

Regulatory Elements for TEX11 Gene

Enhancers for TEX11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TEX11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEX11 Gene

Chromosome:
X
Start:
70,525,561 bp from pter
End:
70,908,731 bp from pter
Size:
383,171 bases
Orientation:
Minus strand

Genomic View for TEX11 Gene

Genes around TEX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX11 Gene

Proteins for TEX11 Gene

  • Protein details for TEX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF3-TEX11_HUMAN
    Recommended name:
    Testis-expressed sequence 11 protein
    Protein Accession:
    Q8IYF3
    Secondary Accessions:
    • A8K8V6
    • Q5JQQ8
    • Q96LZ4
    • Q96M47
    • Q9BXU6

    Protein attributes for TEX11 Gene

    Size:
    940 amino acids
    Molecular mass:
    107889 Da
    Quaternary structure:
    • Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
    SequenceCaution:
    • Sequence=AAK31973.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI39958.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI40155.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX11 Gene

Post-translational modifications for TEX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX11 Gene

Antibody Products

  • Abcam antibodies for TEX11

No data available for DME Specific Peptides for TEX11 Gene

Domains & Families for TEX11 Gene

Protein Domains for TEX11 Gene

Suggested Antigen Peptide Sequences for TEX11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYF3

UniProtKB/Swiss-Prot:

TEX11_HUMAN :
  • Belongs to the SPO22 family.
Family:
  • Belongs to the SPO22 family.
genes like me logo Genes that share domains with TEX11: view

No data available for Gene Families for TEX11 Gene

Function for TEX11 Gene

Molecular function for TEX11 Gene

UniProtKB/Swiss-Prot Function:
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

Gene Ontology (GO) - Molecular Function for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEX11: view
genes like me logo Genes that share phenotypes with TEX11: view

Human Phenotype Ontology for TEX11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX11 Gene

MGI Knock Outs for TEX11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TEX11 Gene

Localization for TEX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX11 Gene

Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX11 Gene COMPARTMENTS Subcellular localization image for TEX11 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000795 colocalizes_with synaptonemal complex ISS --
GO:0000801 central element IEA --
genes like me logo Genes that share ontologies with TEX11: view

Pathways & Interactions for TEX11 Gene

SuperPathways for TEX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IEA --
GO:0006311 meiotic gene conversion ISS --
GO:0007060 male meiosis chromosome segregation IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007131 reciprocal meiotic recombination ISS --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Pathways by source and SIGNOR curated interactions for TEX11 Gene

Drugs & Compounds for TEX11 Gene

No Compound Related Data Available

Transcripts for TEX11 Gene

mRNA/cDNA for TEX11 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX11 Gene

Testis expressed 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX11 Gene

No ASD Table

Relevant External Links for TEX11 Gene

GeneLoc Exon Structure for
TEX11
ECgene alternative splicing isoforms for
TEX11

Expression for TEX11 Gene

mRNA expression in normal human tissues for TEX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX11 Gene

This gene is overexpressed in Testis (x25.0) and Pancreas (x21.7).

Protein differential expression in normal tissues from HIPED for TEX11 Gene

This gene is overexpressed in Bone (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX11 Gene



Protein tissue co-expression partners for TEX11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX11 Gene:

TEX11

SOURCE GeneReport for Unigene cluster for TEX11 Gene:

Hs.121776

mRNA Expression by UniProt/SwissProt for TEX11 Gene:

Q8IYF3-TEX11_HUMAN
Tissue specificity: Testis-specific. Not expressed in adult ovaries.
genes like me logo Genes that share expression patterns with TEX11: view

Primer Products

Orthologs for TEX11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEX11 34
  • 79.79 (n)
  • 65.1 (a)
TEX11 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEX11 34
  • 84.46 (n)
  • 73.47 (a)
TEX11 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tex11 34
  • 74.23 (n)
  • 56.26 (a)
Tex11 16
Tex11 35
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEX11 34
  • 99.1 (n)
  • 98.05 (a)
TEX11 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex11 34
  • 73.67 (n)
  • 56.44 (a)
oppossum
(Monodelphis domestica)
Mammalia TEX11 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEX11 34
  • 63 (n)
  • 53.09 (a)
TEX11 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEX11 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tex11 34
  • 56.74 (n)
  • 48.71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC797197 34
  • 56.16 (n)
  • 47.84 (a)
TEX11 35
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for TEX11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX11 Gene

ENSEMBL:
Gene Tree for TEX11 (if available)
TreeFam:
Gene Tree for TEX11 (if available)

Paralogs for TEX11 Gene

No data available for Paralogs for TEX11 Gene

Variants for TEX11 Gene

Sequence variations from dbSNP and Humsavar for TEX11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6525433 - 70,853,309(+) ATTCT(C/T)TTCCT reference, missense
rs4844247 - 70,670,451(+) CATTT(C/T)ATCAG reference, missense
rs143246552 Spermatogenic failure, X-linked, 2 (SPGFX2) 70,853,093(+) CTCCA(C/T)GGTCA reference, missense
rs140984555 Spermatogenic failure, X-linked, 2 (SPGFX2) 70,605,421(+) TGAAG(C/T)TTTTC reference, missense
rs747672000 -- 70,732,407(+) CCATC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv1629284 CNV insertion 17803354
esv2667978 CNV deletion 23128226
esv2740210 CNV deletion 23290073
esv2740211 CNV deletion 23290073
esv33082 CNV loss 17666407
esv3558956 CNV deletion 23714750
esv3558958 CNV deletion 23714750
esv3574038 CNV loss 25503493
esv3574039 CNV loss 25503493
nsv1073946 CNV deletion 25765185
nsv1076712 CNV duplication 25765185
nsv1119345 CNV duplication 24896259
nsv1128539 CNV deletion 24896259
nsv1129341 OTHER inversion 24896259
nsv1139408 CNV deletion 24896259
nsv425085 CNV deletion 16902084
nsv473008 CNV novel sequence insertion 20440878
nsv475135 CNV novel sequence insertion 20440878
nsv475250 CNV novel sequence insertion 20440878
nsv507968 OTHER sequence alteration 20534489
nsv510931 OTHER complex 20534489
nsv517078 CNV gain 19592680

Variation tolerance for TEX11 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX11 Gene

Human Gene Mutation Database (HGMD)
TEX11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX11 Gene

Disorders for TEX11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEX11 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure, x-linked, 2
  • male infertility from defect in meiosis
azoospermia
  • spermatogenic failure
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search TEX11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEX11_HUMAN
  • Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest. {ECO:0000269 PubMed:25970010}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TEX11

Genetic Association Database (GAD)
TEX11
Human Genome Epidemiology (HuGE) Navigator
TEX11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX11
genes like me logo Genes that share disorders with TEX11: view

No data available for Genatlas for TEX11 Gene

Publications for TEX11 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 65
  2. X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. (PMID: 25970010) Yatsenko A.N. … Tuettelmann F. (N. Engl. J. Med. 2015) 3 4 65
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. (PMID: 26136358) Yang F. … Wang P.J. (EMBO Mol Med 2015) 3 65

Products for TEX11 Gene

Sources for TEX11 Gene

Content