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TEX11 Gene

protein-coding   GIFtS: 50
GCID: GC0XM069748

Testis Expressed 11

(Previous name: testis expressed sequence 11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Expressed 111 2
Testis Expressed Sequence 111 2
TGC12
TSGA32
Testis-Expressed Sequence 11 Protein2

External Ids:    HGNC: 117331   Entrez Gene: 561592   Ensembl: ENSG000001204987   OMIM: 3003115   UniProtKB: Q8IYF33   

Export aliases for TEX11 gene to outside databases

Previous GC identifers: GC0XM065926 GC0XM067226 GC0XM067982 GC0XM068615 GC0XM069531 GC0XM069665 GC0XM063570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEX11 Gene:
This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEX11 Gene:
TEX11 (testis expressed 11) is a protein-coding gene.

UniProtKB/Swiss-Prot: TEX11_HUMAN, Q8IYF3
Function: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome
synapsis and formation of crossovers (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEX11 gene promoter:
         Brachyury   FOXD3   NRSF form 2   AREB6   FOXC1   Nkx6-1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX11 promoter sequence
   Search Chromatin IP Primers for TEX11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xp11

TEX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM069748:  view genomic region     (about GC identifiers)

Start:
69,748,790 bp from pter      End:
70,128,581 bp from pter
Size:
379,792 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEX11_HUMAN, Q8IYF3 (See protein sequence)
Recommended Name: Testis-expressed sequence 11 protein  
Size: 940 amino acids; 107889 Da
Subunit: Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By
similarity)
Sequence caution: Sequence=AAK31973.1; Type=Erroneous initiation; Sequence=CAI39958.1; Type=Erroneous initiation;
Sequence=CAI40155.1; Type=Erroneous initiation; Sequence=CAI41496.1; Type=Erroneous initiation;
Secondary accessions: A8K8V6 Q5JQQ8 Q96LZ4 Q96M47 Q9BXU6
Alternative splicing: 3 isoforms:  Q8IYF3-1   Q8IYF3-2   Q8IYF3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEX11: NX_Q8IYF3

Explore proteomics data for TEX11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEX11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003811.1  NP_112566.2  

    ENSEMBL proteins: 
     ENSP00000363453   ENSP00000363440   ENSP00000379226   ENSP00000340995  

    TEX11 Human Recombinant Protein Products:

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    Novus Biologicals TEX11 Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for TEX11

     
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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for TEX11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013940 Meiosis_specific_SPO22

    Graphical View of Domain Structure for InterPro Entry Q8IYF3

    ProtoNet protein and cluster: Q8IYF3

    UniProtKB/Swiss-Prot: TEX11_HUMAN, Q8IYF3
    Similarity: Belongs to the SPO22 family


    Find genes that share domains with TEX11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEX11_HUMAN, Q8IYF3
    Function: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome
    synapsis and formation of crossovers (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with TEX11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TEX11:
     Decreased melanin production 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tex11):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with TEX11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tex11tm1.1Jpt for TEX11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEX11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEX11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEX11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEX11

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEX11_HUMAN, Q8IYF3: Chromosome (By similarity). Note=Forms arrays of discrete foci along synaptonemal complexes
    in spermatocytes and fetal oocytes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome ----
    GO:0000795colocalizes with synaptonemal complex ISS--
    GO:0000801central element IEA--

    Find genes that share ontologies with TEX11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEX11
    Interactions:

        Search GeneGlobe Interaction Network for TEX11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEX11 (Q8IYF31, 2, 3 ENSP000003409954) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN37Q96GY31, 2, 3, ENSP000003011594EBI-742397,EBI-748884 MINT-67376 I2D: score=6 STRING: ENSP00000301159
    MAD1L1Q9Y6D92, 3, ENSP000003825624MINT-66279 I2D: score=5 STRING: ENSP00000382562
    SNX7Q9UNH62, 3, ENSP000003044294MINT-68351 I2D: score=5 STRING: ENSP00000304429
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-66758 I2D: score=5 STRING: ENSP00000300181
    CCDC11Q96M912, 3, ENSP000003815534MINT-66836 I2D: score=4 STRING: ENSP00000381553
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000712resolution of meiotic recombination intermediates IEA--
    GO:0006311meiotic gene conversion ISS--
    GO:0007060male meiosis chromosome segregation IEA--
    GO:0007130synaptonemal complex assembly IEA--
    GO:0007131reciprocal meiotic recombination ISS--

    Find genes that share ontologies with TEX11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEX11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEX11 gene (2 alternative transcripts): 
    NM_001003811.1  NM_031276.2  

    Unigene Cluster for TEX11:

    Testis expressed 11
    Hs.121776  [show with all ESTs]
    Unigene Representative Sequence: NM_001003811
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374333(uc004dym.3) ENST00000374320(uc004dyk.3) ENST00000395889(uc004dyl.3)
    ENST00000344304
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TEX11
      QuantiFast Probe-based Assays in human, mouse, rat TEX11

    Additional mRNA sequence: 

    AF285594.1 AK057391.1 AK057523.1 AK292471.1 BC036016.1 

    4 DOTS entries:

    DT.100018091  DT.204933  DT.100749772  DT.100018092 

    1 AceView cDNA sequence:

    BG722191 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEX11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGATAC
    TEX11 Expression
    About this image


    TEX11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
    TEX11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEX11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121776

    UniProtKB/Swiss-Prot: TEX11_HUMAN, Q8IYF3
    Tissue specificity: Testis-specific. Not expressed in adult ovaries

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TEX11 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex111 , 5 testis expressed gene 111, 5 74.23(n)1
    56.26(a)1
      X (43.72 cM)5
    835581  NM_031384.21  NP_113561.21 
     1008386485 
    chicken
    (Gallus gallus)
    Aves TEX111 testis expressed 11 63(n)
    53.09(a)
      422215  XM_004940643.1  XP_004940700.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEX116
    testis expressed 11
    49(a)
    1 ↔ 1
    GL343758.1(52226-73935)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tex111 testis expressed 11 56.74(n)
    48.71(a)
      100494809  XM_002934898.2  XP_002934944.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7971971 testis-expressed sequence 11 protein-like 56.16(n)
    47.84(a)
      797197  XM_001922537.4  XP_001922572.3 


    ENSEMBL Gene Tree for TEX11 (if available)
    TreeFam Gene Tree for TEX11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEX11 (see all 5145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15362501,2
    C,F,A,H--69749852(+) TTTCTG/ATAATC 2 -- int120Minor allele frequency- A:0.12NA EA MN NS WA CSA 2415
    rs15362511,2
    C,F,A,H--69749853(+) TTCTAA/TAATCC 2 -- int18Minor allele frequency- T:0.09MN NS EA WA NA 608
    rs798245801,2
    C--69751372(+) AAACA-/AAA   
      C
    /AACA
    TGATC
    2 -- int10--------
    rs1902645861,2
    --69751375(+) TTAAAC/GAAACA 2 -- int10--------
    rs1416112181,2
    C--69756298(+) GGCTA-/T/TT  
            
    ATTTT
    2 -- ds5001 int10--------
    rs1996805211,2
    C--69756299(+) GGCTA-/TTTTTT 2 -- ds5001 int10--------
    rs1840528851,2
    C--69756333(+) ATGGAA/GTTTTG 2 -- ds5001 int10--------
    rs1874521981,2
    C--69756418(+) TTACAA/GGCACA 2 -- ds5001 int10--------
    rs1911858671,2
    --69756567(+) TTCTTC/TGATAT 2 -- ds5001 int10--------
    rs1829843911,2
    C--69756787(+) AGTTTA/GTTCAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TEX11 (69748790 - 69998790 bp, first 250kb of TEX11)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TEX11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740211CNV Deletion23290073
    esv2667978CNV Deletion23128226
    esv2740210CNV Deletion23290073
    esv1629284CNV Insertion17803354
    nsv507968CNV Insertion20534489
    esv33082CNV Loss17666407
    nsv425085CNV Loss16902084
    nsv517078CNV Gain19592680
    nsv510931CNV Complex20534489
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): TEX11

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300311    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TEX11:
    Male infertility

    Find genes that share disorders with TEX11           About GenesLikeMe

    Genetic Association Database (GAD): TEX11
    Human Genome Epidemiology (HuGE) Navigator: TEX11 (1 document)

    Export disorders for TEX11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEX11 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TEX11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. (PubMed id 18369460)2 Adelman C.A. and Petrini J.H. (PLoS Genet. 2008)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56159 HGNC: 11733 AceView: TEX11.1 Ensembl:ENSG00000120498 euGenes: HUgn56159
    ECgene: TEX11 H-InvDB: TEX11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TEX11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TEX11 gene:
    Search GeneIP for patents involving TEX11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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