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Aliases for TEX11 Gene

Aliases for TEX11 Gene

  • Testis Expressed 11 2 3 5
  • Testis Expressed Sequence 11 2 3
  • SPGFX2 3
  • TSGA3 3
  • TGC1 3

External Ids for TEX11 Gene

Previous GeneCards Identifiers for TEX11 Gene

  • GC0XM065926
  • GC0XM067226
  • GC0XM067982
  • GC0XM068615
  • GC0XM069531
  • GC0XM069665
  • GC0XM069748
  • GC0XM063570

Summaries for TEX11 Gene

Entrez Gene Summary for TEX11 Gene

  • This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX11 Gene

TEX11 (Testis Expressed 11) is a Protein Coding gene. Diseases associated with TEX11 include Spermatogenic Failure, X-Linked, 2 and Azoospermia.

UniProtKB/Swiss-Prot for TEX11 Gene

  • Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX11 Gene

Genomics for TEX11 Gene

Regulatory Elements for TEX11 Gene

Enhancers for TEX11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TEX11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEX11 Gene

70,525,561 bp from pter
70,908,731 bp from pter
383,171 bases
Minus strand

Genomic View for TEX11 Gene

Genes around TEX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX11 Gene

Proteins for TEX11 Gene

  • Protein details for TEX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-expressed sequence 11 protein
    Protein Accession:
    Secondary Accessions:
    • A8K8V6
    • Q5JQQ8
    • Q96LZ4
    • Q96M47
    • Q9BXU6

    Protein attributes for TEX11 Gene

    940 amino acids
    Molecular mass:
    107889 Da
    Quaternary structure:
    • Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
    • Sequence=AAK31973.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI39958.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI40155.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX11 Gene


neXtProt entry for TEX11 Gene

Proteomics data for TEX11 Gene at MOPED

Post-translational modifications for TEX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX11 Gene

Antibody Products

  • Abcam antibodies for TEX11
  • Santa Cruz Biotechnology (SCBT) Antibodies for TEX11

No data available for DME Specific Peptides for TEX11 Gene

Domains & Families for TEX11 Gene

Protein Domains for TEX11 Gene

Suggested Antigen Peptide Sequences for TEX11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPO22 family.
  • Belongs to the SPO22 family.
genes like me logo Genes that share domains with TEX11: view

No data available for Gene Families for TEX11 Gene

Function for TEX11 Gene

Molecular function for TEX11 Gene

UniProtKB/Swiss-Prot Function:
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).
genes like me logo Genes that share phenotypes with TEX11: view

Human Phenotype Ontology for TEX11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX11 Gene

MGI Knock Outs for TEX11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for TEX11 Gene

Localization for TEX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX11 Gene

Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TEX11 Gene COMPARTMENTS Subcellular localization image for TEX11 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000801 central element IEA --
genes like me logo Genes that share ontologies with TEX11: view

Pathways & Interactions for TEX11 Gene

SuperPathways for TEX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IEA --
GO:0006311 meiotic gene conversion ISS --
GO:0007130 synaptonemal complex assembly IEA --
GO:0008584 male gonad development IEA --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Pathways by source and SIGNOR curated interactions for TEX11 Gene

Drugs & Compounds for TEX11 Gene

No Compound Related Data Available

Transcripts for TEX11 Gene

mRNA/cDNA for TEX11 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX11 Gene

Testis expressed 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEX11 Gene

No ASD Table

Relevant External Links for TEX11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEX11 Gene

mRNA expression in normal human tissues for TEX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX11 Gene

This gene is overexpressed in Testis (x25.0) and Pancreas (x21.7).

Protein differential expression in normal tissues from HIPED for TEX11 Gene

This gene is overexpressed in Bone (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX11 Gene

SOURCE GeneReport for Unigene cluster for TEX11 Gene Hs.121776

mRNA Expression by UniProt/SwissProt for TEX11 Gene

Tissue specificity: Testis-specific. Not expressed in adult ovaries.
genes like me logo Genes that share expression patterns with TEX11: view

Protein tissue co-expression partners for TEX11 Gene

Primer Products

Orthologs for TEX11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TEX11 35
  • 79.79 (n)
  • 65.1 (a)
TEX11 36
  • 65 (a)
(Canis familiaris)
Mammalia TEX11 35
  • 84.46 (n)
  • 73.47 (a)
TEX11 36
  • 73 (a)
(Mus musculus)
Mammalia Tex11 35
  • 74.23 (n)
  • 56.26 (a)
Tex11 16
Tex11 36
  • 53 (a)
(Pan troglodytes)
Mammalia TEX11 35
  • 99.1 (n)
  • 98.05 (a)
TEX11 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Tex11 35
  • 73.67 (n)
  • 56.44 (a)
(Monodelphis domestica)
Mammalia TEX11 36
  • 49 (a)
(Gallus gallus)
Aves TEX11 35
  • 63 (n)
  • 53.09 (a)
TEX11 36
  • 51 (a)
(Anolis carolinensis)
Reptilia TEX11 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tex11 35
  • 56.74 (n)
  • 48.71 (a)
(Danio rerio)
Actinopterygii LOC797197 35
  • 56.16 (n)
  • 47.84 (a)
TEX11 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for TEX11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX11 Gene

Gene Tree for TEX11 (if available)
Gene Tree for TEX11 (if available)

Paralogs for TEX11 Gene

No data available for Paralogs for TEX11 Gene

Variants for TEX11 Gene

Sequence variations from dbSNP and Humsavar for TEX11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6525433 - 70,853,309(+) ATTCT(C/T)TTCCT reference, missense
rs4844247 - 70,670,451(+) CATTT(C/T)ATCAG reference, missense
VAR_073889 Spermatogenic failure, X-linked, 2 (SPGFX2)
VAR_073890 Spermatogenic failure, X-linked, 2 (SPGFX2)
rs747672000 -- 70,732,407(+) CCATC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv517078 CNV Gain 19592680
nsv510931 CNV Complex 20534489
esv2740210 CNV Deletion 23290073
nsv507968 CNV Insertion 20534489
nsv425085 CNV Loss 16902084
esv1629284 CNV Insertion 17803354
esv2740211 CNV Deletion 23290073
esv2667978 CNV Deletion 23128226

Variation tolerance for TEX11 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX11 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX11 Gene

Disorders for TEX11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEX11 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure, x-linked, 2
  • male infertility from defect in meiosis
  • spermatogenic failure
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search TEX11 in MalaCards View complete list of genes associated with diseases


  • Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest. {ECO:0000269 PubMed:25970010}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TEX11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TEX11: view

No data available for Genatlas for TEX11 Gene

Publications for TEX11 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. (PMID: 25970010) Yatsenko A.N. … Tuettelmann F. (N. Engl. J. Med. 2015) 3
  3. TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. (PMID: 26136358) Yang F. … Wang P.J. (EMBO Mol Med 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TEX11 Gene

Sources for TEX11 Gene