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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEX10 Gene

protein-coding   GIFtS: 46
GCID: GC09M103064

testis expressed 10

(Previous names: testis expressed gene 10, testis expressed sequence 10...)
 Explore 2 diseases affiliated with
TEX10 via our new
 Human Malady Compendium 
Biological research products
for TEX10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Testis Expressed 101 2     Testis Expressed Sequence 101 2
Ipi11 2     FLJ202871
BA208F1.21     Testis-Expressed Sequence 10 Protein2
Testis Expressed Gene 101 2     

External Ids:    HGNC: 259881   Entrez Gene: 548812   Ensembl: ENSG000001368917   UniProtKB: Q9NXF13   

Export aliases for TEX10 gene to outside databases

Previous GC identifers: GC09M098445 GC09M100143 GC09M102104 GC09M072663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TEX10_HUMAN, Q9NXF1
Function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is
recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148
target genes

Gene Wiki entry for TEX10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEX10 gene promoter:
         HOXA3   CUTL1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LCR-F1   POU3F2   C/EBPalpha   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEX10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEX10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31.1

TEX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M103064:  view genomic region     (about GC identifiers)

Start:
103,064,357 bp from pter      End:
103,115,259 bp from pter
Size:
50,903 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEX10_HUMAN, Q9NXF1 (See protein sequence)
Recommended Name: Testis-expressed sequence 10 protein  
Size: 929 amino acids; 105674 Da
Subunit: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and
RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA,
KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with
methylated CHTOP and ZNF148
Subcellular location: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Nucleus membrane; Multi-pass
membrane protein. Nucleus, nucleolus. Note=Mainly found in the nucleoplasm, with low levels detected in the
cytoplasmic and chromatin fractions (By similarity)
Sequence caution: Sequence=CAI12537.1; Type=Erroneous gene model prediction; Sequence=CAI39742.1; Type=Erroneous gene
model prediction;
Secondary accessions: B4DYV2 Q5T722 Q5T723 Q8NCN8 Q8TDY0
Alternative splicing: 2 isoforms:  Q9NXF1-1   Q9NXF1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEX10: NX_Q9NXF1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NXF1

  • TEX10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155056.1  NP_060216.2  

    ENSEMBL proteins: 
     ENSP00000364037   ENSP00000399872   ENSP00000444555   ENSP00000438120  

    Human Recombinant Protein Products: 
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    Novus Biologicals TEX10 Protein
    Novus Biologicals TEX10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TEX10

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0071339MLL1 complex IDA15960975


    TEX10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TEX10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TEX10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR024679 IPI1/TEX10
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NXF1

    ProtoNet protein and cluster: Q9NXF1

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: TEX10_HUMAN, Q9NXF1
    Similarity: Contains 1 HEAT repeat


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TEX10_HUMAN, Q9NXF1
    Function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is
    recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148
    target genes

    miRNA
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX10

    1 GenomeRNAi human phenotype for TEX10:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/150 Interacting proteins for TEX10 (Q9NXF12, 3 ENSP000003640374) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR18Q9BV382, 3, ENSP000002512894MINT-8150073 MINT-8149992 MINT-8150055 MINT-8151622 MINT-6488791 I2D: score=1 STRING: ENSP00000251289
    SENP3Q9H4L42, 3, ENSP000003140294MINT-8151574 MINT-8151622 I2D: score=1 STRING: ENSP00000314029
    PTPN12Q052092, 3MINT-61771 I2D: score=3 
    PELP1Q8IZL82, 3, ENSP000003013964MINT-8150073 MINT-8150055 MINT-8149978 MINT-8151622 MINT-6488791 I2D: score=1 STRING: ENSP00000301396
    LAS1LQ9Y4W22, ENSP000003639444MINT-8151622 MINT-6488791 STRING: ENSP00000363944
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX10
    Search CenterWatch for drugs/clinical trials and news about TEX10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEX10 gene (2 alternative transcripts): 
    NM_001161584.1  NM_017746.3  

    Unigene Cluster for TEX10:

    Testis expressed 10
    Hs.494648  [show with all ESTs]
    Unigene Representative Sequence: NM_017746
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374902(uc011lvf.2 uc004bas.3) ENST00000477648 ENST00000429235
    ENST00000535814(uc011lvg.2) ENST00000537512(uc011lvh.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEX10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TEX10
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    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEX10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEX10

    Additional cDNA sequence: 

    AB060968.1 AJ420436.1 AK000294.1 AK055719.1 AK298916.1 AK302619.1 AY598337.1 BC030652.2 

    12 DOTS entries:

    DT.449369  DT.100838042  DT.121159816  DT.100783364  DT.115451  DT.40133115  DT.91750849  DT.99971373 
    DT.95168444  DT.97772028  DT.91750846  DT.91750853 

    24/200 AceView cDNA sequences (see all 200):

    AA233459 BM460702 T34973 AW593024 CA312967 AI288689 AI569471 BX109594 
    CA419187 BG032216 CR593934 BX384524 AB060968 Z40741 AA305779 BQ017038 
    CB136072 BM557865 BP338872 BE675369 AA447126 AL705925 BP375850 BG285243 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TEX10    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                                                                      -                           
    SP2:                                      -     -                                                                     
    SP3:                    -                                                                                             
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for TEX10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEX10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCCCTCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TEX10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEX10

    SOURCE GeneReport for Unigene cluster: Hs.494648
        SABiosciences Custom PCR Arrays for TEX10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEX10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TEX10 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tex101 , 5 testis expressed gene 101, 5 88.93(n)1
    88.78(a)1
      4 (26.13 cM)5
    2695361  NM_172304.31  NP_758508.21 
     484308585 
    chicken
    (Gallus gallus)
    Aves TEX101 testis expressed 10 72.94(n)
    73.24(a)
      420993  NM_001031008.1  NP_001026179.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEX106
    --
    66(a)
    1 ↔ 1
    6(54968395-55020753)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63812 Transcribed sequence with weak similarity to protein more 77.45(n)    BX714021.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.101722 Danio rerio mRNA similar to hypothetical protein FLJ2 more 71.75(n)    BC044417.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15751 CG1575 44.41(n)
    34.93(a)
      31731  NM_132212.2  NP_572440.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48A6C.46
    Protein Y48A6C.4
    23(a)
    1 ↔ 1
    III(11119697-11127073)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G046806
    AT5G270106
    (see all 3)
    uncharacterized protein
    armadillo/beta-catenin-like repeat-containing prot...
    (see all 3)
    22(a)
    17(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    4(2372266-2373327)
    5(9503315-9507569)
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    17(a)
    1 ↔ 1
    4(23133221-23141636)


    ENSEMBL Gene Tree for TEX10 (if available)
    TreeFam Gene Tree for TEX10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/861 NCBI SNPs in TEX10 are shown (see all 861    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345209511,2
    C,F--72674837(+) TGGTC-/AAAAAA 1 -- int13Minor allele frequency- A:0.33NA CSA 6
    rs1404264981,2
    --103063954(+) TAAAC-/AGTGAT 2 -- int10--------
    rs1826678581,2
    --103063986(+) TGGGGA/GTTGCT 2 -- int10--------
    rs1862479211,2
    --103063991(+) GTTGCG/TTTCAT 2 -- int10--------
    rs1449788301,2
    C,--103064034(+) GTAAG-/AGAT  
            
    AGATA
    2 -- int10--------
    rs1905679991,2
    --103064035(+) GTAAGA/CGATAG 2 -- int10--------
    rs120038111,2
    C,F,H,--103064060(+) AAGTGT/CTCACT 2 -- int111Minor allele frequency- C:0.05NS EA NA WA CSA 546
    rs1839975441,2
    --103064120(+) GATCAC/TAAAAA 2 -- int10--------
    rs1390715571,2
    --103064125(+) CAAAAA/TCACAA 2 -- int10--------
    rs109890491,2
    C,F,A,H,--103064153(+) GATGGG/AATTAC 2 -- int128Minor allele frequency- A:0.28NS EA NA WA CSA 2770

    HapMap Linkage Disequilibrium report for TEX10 (103064357 - 103115259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TEX10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEX10
    DNA2.0 Custom Variant and Variant Library Synthesis for TEX10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TEX10 for disorders           About GeneDecksing

    2 diseases for TEX10:    About MalaCards
    lung cancer    neuroblastoma


    Export disorders for TEX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEX10 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with TEX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    7. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. Five Friends of Methylated Chtop, a complex linking arginine methylation to desumoylation. (PubMed id 22872859)2 Fanis P....van Dijk T.B. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54881 HGNC: 25988 AceView: TEX10 Ensembl:ENSG00000136891 euGenes: HUgn54881
    ECgene: TEX10 H-InvDB: TEX10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEX10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEX10 gene:
    Search GeneIP for patents involving TEX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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