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Aliases for TEX10 Gene

Aliases for TEX10 Gene

  • Testis Expressed 10 2 3 5
  • Testis Expressed Gene 10 2 3
  • Testis-Expressed Sequence 10 Protein 3
  • Testis Expressed Sequence 10 2
  • BA208F1.2 3
  • Ipi1 3

External Ids for TEX10 Gene

Previous GeneCards Identifiers for TEX10 Gene

  • GC09M098445
  • GC09M100143
  • GC09M102104
  • GC09M103064
  • GC09M072663

Summaries for TEX10 Gene

GeneCards Summary for TEX10 Gene

TEX10 (Testis Expressed 10) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for TEX10 Gene

  • Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Wiki entry for TEX10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX10 Gene

Genomics for TEX10 Gene

Regulatory Elements for TEX10 Gene

Enhancers for TEX10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F100351 0.2 ENCODE 30.6 +0.3 285 2.4 HDGF CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 KLF13 TEX10 INVS GC09P100306
GH09F100332 0.2 ENCODE 29.9 +19.8 19812 1.4 TEX10 MSANTD3 MSANTD3-TMEFF1 TMEFF1 INVS GC09P100306
GH09F100379 0.8 Ensembl ENCODE 21.7 -27.0 -26999 1.6 TEX10 INVS LOC105376177 MSANTD3
GH09F100097 0.2 ENCODE 19.4 +254.0 253971 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 STX17 TEX10 INVS RN7SL75P ERP44 LOC105376176
GH09F100410 0.7 Ensembl ENCODE 11.6 -58.4 -58424 2.0 ARID4B SIN3A DMAP1 ZNF143 ZNF263 SP3 NFYC MXD4 ZNF518A KAT8 TMEFF1 TEX10 MSANTD3-TMEFF1 MURC MSANTD3 LOC105376177
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TEX10 on UCSC Golden Path with GeneCards custom track

Promoters for TEX10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001310121 477 2601 HDGF MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 KLF13 ZNF263

Genomic Location for TEX10 Gene

Chromosome:
9
Start:
100,302,075 bp from pter
End:
100,352,977 bp from pter
Size:
50,903 bases
Orientation:
Minus strand

Genomic View for TEX10 Gene

Genes around TEX10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX10 Gene

Proteins for TEX10 Gene

  • Protein details for TEX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF1-TEX10_HUMAN
    Recommended name:
    Testis-expressed sequence 10 protein
    Protein Accession:
    Q9NXF1
    Secondary Accessions:
    • B4DYV2
    • Q5T722
    • Q5T723
    • Q8NCN8
    • Q8TDY0

    Protein attributes for TEX10 Gene

    Size:
    929 amino acids
    Molecular mass:
    105674 Da
    Quaternary structure:
    • Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
    SequenceCaution:
    • Sequence=CAI12537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX10 Gene

Post-translational modifications for TEX10 Gene

  • Ubiquitination at Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for TEX10 Gene

No data available for DME Specific Peptides for TEX10 Gene

Domains & Families for TEX10 Gene

Gene Families for TEX10 Gene

Protein Domains for TEX10 Gene

Suggested Antigen Peptide Sequences for TEX10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXF1

UniProtKB/Swiss-Prot:

TEX10_HUMAN :
  • Contains 1 HEAT repeat.
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with TEX10: view

Function for TEX10 Gene

Molecular function for TEX10 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 21326211
genes like me logo Genes that share ontologies with TEX10: view
genes like me logo Genes that share phenotypes with TEX10: view

Animal Models for TEX10 Gene

MGI Knock Outs for TEX10:

Animal Model Products

miRNA for TEX10 Gene

miRTarBase miRNAs that target TEX10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX10 Gene

Localization for TEX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX10 Gene

Nucleus, nucleoplasm. Cytoplasm. Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX10 Gene COMPARTMENTS Subcellular localization image for TEX10 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TEX10: view

Pathways & Interactions for TEX10 Gene

genes like me logo Genes that share pathways with TEX10: view

Gene Ontology (GO) - Biological Process for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing TAS --
GO:0030174 regulation of DNA-dependent DNA replication initiation IBA --
genes like me logo Genes that share ontologies with TEX10: view

No data available for SIGNOR curated interactions for TEX10 Gene

Transcripts for TEX10 Gene

Unigene Clusters for TEX10 Gene

Testis expressed 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for TEX10 Gene

GeneLoc Exon Structure for
TEX10
ECgene alternative splicing isoforms for
TEX10

Expression for TEX10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX10 Gene

Protein differential expression in normal tissues from HIPED for TEX10 Gene

This gene is overexpressed in Fetal gut (10.5), Fetal testis (8.0), and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TEX10 Gene



Protein tissue co-expression partners for TEX10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX10 Gene:

TEX10

SOURCE GeneReport for Unigene cluster for TEX10 Gene:

Hs.494648
genes like me logo Genes that share expression patterns with TEX10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TEX10 Gene

Orthologs for TEX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEX10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX10 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia TEX10 34 35
  • 94.51 (n)
cow
(Bos Taurus)
Mammalia TEX10 34 35
  • 92.53 (n)
mouse
(Mus musculus)
Mammalia Tex10 34 16 35
  • 88.93 (n)
rat
(Rattus norvegicus)
Mammalia Tex10 34
  • 88.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TEX10 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEX10 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEX10 34 35
  • 73.05 (n)
lizard
(Anolis carolinensis)
Reptilia TEX10 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tex10 34
  • 62.06 (n)
Str.6381 34
zebrafish
(Danio rerio)
Actinopterygii tex10 34 35
  • 53.02 (n)
Dr.10172 34
fruit fly
(Drosophila melanogaster)
Insecta CG1575 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.579 35
  • 37 (a)
OneToMany
-- 35
  • 26 (a)
OneToMany
Species where no ortholog for TEX10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX10 Gene

ENSEMBL:
Gene Tree for TEX10 (if available)
TreeFam:
Gene Tree for TEX10 (if available)

Paralogs for TEX10 Gene

No data available for Paralogs for TEX10 Gene

Variants for TEX10 Gene

Sequence variations from dbSNP and Humsavar for TEX10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10117799 -- 100,322,278(+) TAACT(A/C)GGTCT intron-variant
rs10118398 -- 100,344,715(+) GTGGC(A/G)GGCAC intron-variant
rs10118876 -- 100,332,681(+) CCGGG(C/T)GCGGT intron-variant
rs10124133 -- 100,339,673(+) ATTAG(C/T)ATTTT intron-variant
rs10124893 -- 100,302,983(+) TCCCG(A/G)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX10 Gene

Variant ID Type Subtype PubMed ID
nsv507523 OTHER sequence alteration 20534489

Variation tolerance for TEX10 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEX10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX10 Gene

Disorders for TEX10 Gene

Relevant External Links for TEX10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEX10

No disorders were found for TEX10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX10 Gene

Publications for TEX10 Gene

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TEX10 Gene

Sources for TEX10 Gene

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