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Aliases for TEX10 Gene

Aliases for TEX10 Gene

  • Testis Expressed 10 2 3
  • Testis Expressed Sequence 10 2 3
  • Testis Expressed Gene 10 2 3
  • Testis-Expressed Sequence 10 Protein 3
  • BA208F1.2 3
  • TES101RP 6
  • TEX101 6
  • SGRG 6
  • Ipi1 3

External Ids for TEX10 Gene

Previous GeneCards Identifiers for TEX10 Gene

  • GC09M098445
  • GC09M100143
  • GC09M102104
  • GC09M103064
  • GC09M072663

Summaries for TEX10 Gene

GeneCards Summary for TEX10 Gene

TEX10 (Testis Expressed 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TEX10 Gene

  • Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Wiki entry for TEX10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX10 Gene

Genomics for TEX10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TEX10 Gene

Start:
100,302,075 bp from pter
End:
100,352,977 bp from pter
Size:
50,903 bases
Orientation:
Minus strand

Genomic View for TEX10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX10 Gene

Proteins for TEX10 Gene

  • Protein details for TEX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF1-TEX10_HUMAN
    Recommended name:
    Testis-expressed sequence 10 protein
    Protein Accession:
    Q9NXF1
    Secondary Accessions:
    • B4DYV2
    • Q5T722
    • Q5T723
    • Q8NCN8
    • Q8TDY0

    Protein attributes for TEX10 Gene

    Size:
    929 amino acids
    Molecular mass:
    105674 Da
    Quaternary structure:
    • Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
    SequenceCaution:
    • Sequence=CAI12537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX10 Gene

Proteomics data for TEX10 Gene at MOPED

Post-translational modifications for TEX10 Gene

  • Ubiquitination at Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for TEX10 Gene

No data available for DME Specific Peptides for TEX10 Gene

Domains for TEX10 Gene

Protein Domains for TEX10 Gene

Suggested Antigen Peptide Sequences for TEX10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXF1

UniProtKB/Swiss-Prot:

TEX10_HUMAN :
  • Q9NXF1
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with TEX10: view

No data available for Gene Families for TEX10 Gene

Function for TEX10 Gene

Molecular function for TEX10 Gene

UniProtKB/Swiss-Prot Function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 21326211
genes like me logo Genes that share ontologies with TEX10: view

Phenotypes for TEX10 Gene

GenomeRNAi human phenotypes for TEX10:
genes like me logo Genes that share phenotypes with TEX10: view

Animal Model Products

CRISPR Products

miRNA for TEX10 Gene

miRTarBase miRNAs that target TEX10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEX10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TEX10 Gene

Localization for TEX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX10 Gene

Nucleus, nucleoplasm. Cytoplasm. Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEX10 Gene COMPARTMENTS Subcellular localization image for TEX10 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with TEX10: view

Transcripts for TEX10 Gene

Unigene Clusters for TEX10 Gene

Testis expressed 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEX10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for TEX10 Gene

GeneLoc Exon Structure for
TEX10
ECgene alternative splicing isoforms for
TEX10

Expression for TEX10 Gene

mRNA expression in normal human tissues for TEX10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEX10 Gene

SOURCE GeneReport for Unigene cluster for TEX10 Gene Hs.494648

genes like me logo Genes that share expressions with TEX10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TEX10 Gene

Orthologs for TEX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEX10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX10 35
  • 99.74 (n)
  • 99.89 (a)
TEX10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEX10 35
  • 92.53 (n)
  • 93.19 (a)
TEX10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEX10 35
  • 94.51 (n)
  • 95.49 (a)
TEX10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tex10 35
  • 88.93 (n)
  • 88.78 (a)
Tex10 16
Tex10 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEX10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEX10 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tex10 35
  • 88.86 (n)
  • 88.46 (a)
chicken
(Gallus gallus)
Aves TEX10 35
  • 73.05 (n)
  • 73.24 (a)
TEX10 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEX10 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6381 35
tex10 35
  • 62.06 (n)
  • 56.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.10172 35
tex10 35
  • 53.02 (n)
  • 49.16 (a)
tex10 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1575 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
CSA.579 36
  • 37 (a)
OneToMany
Species with no ortholog for TEX10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX10 Gene

ENSEMBL:
Gene Tree for TEX10 (if available)
TreeFam:
Gene Tree for TEX10 (if available)

Paralogs for TEX10 Gene

No data available for Paralogs for TEX10 Gene

Variants for TEX10 Gene

Sequence variations from dbSNP and Humsavar for TEX10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7472 -- 100,302,248(-) TGCTT(C/T)AACGT reference, synonymous-codon
rs13629 -- 100,307,409(-) ggtta(C/G)ttagt intron-variant
rs914711 -- 100,349,423(-) TTCAT(A/C)ATTTA intron-variant
rs944710 -- 100,350,177(-) TAAGT(A/G)CAAGG intron-variant
rs959893 -- 100,334,384(-) AGATT(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEX10 Gene

Variant ID Type Subtype PubMed ID
nsv893623 CNV Gain 21882294
nsv507523 CNV Insertion 20534489

Relevant External Links for TEX10 Gene

HapMap Linkage Disequilibrium report
TEX10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX10 Gene

Disorders for TEX10 Gene

No disorders were found for TEX10 Gene.

No data available for UniProtKB/Swiss-Prot for TEX10 Gene

Publications for TEX10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4

Products for TEX10 Gene

Sources for TEX10 Gene

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