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Aliases for TET3 Gene

Aliases for TET3 Gene

  • Tet Methylcytosine Dioxygenase 3 2 3 5
  • Tet Oncogene Family Member 3 2 3
  • EC 1.14.11.n2 4 61
  • Probable Methylcytosine Dioxygenase TET3 3
  • Putative Methylcytosine Dioxygenase 3
  • Methylcytosine Dioxygenase TET3 3
  • HCG_40738 3
  • KIAA0401 4

External Ids for TET3 Gene

Previous GeneCards Identifiers for TET3 Gene

  • GC02P074127
  • GC02P074213
  • GC02P074009
  • GC02P074229

Summaries for TET3 Gene

Entrez Gene Summary for TET3 Gene

  • Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TET3 Gene

TET3 (Tet Methylcytosine Dioxygenase 3) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. GO annotations related to this gene include methylcytosine dioxygenase activity. An important paralog of this gene is TET2.

UniProtKB/Swiss-Prot for TET3 Gene

  • Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TET3 Gene

Genomics for TET3 Gene

Regulatory Elements for TET3 Gene

Enhancers for TET3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073892 1.7 FANTOM5 Ensembl ENCODE 10.4 -89.6 -89586 3.2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 STAMBP SEMA4F SMYD5 ACTG2 C2orf81 MTHFD2 DGUOK TET3 DCTN1 BOLA3
GH02F074035 1.3 Ensembl ENCODE 12.7 +56.5 56499 8.5 ATF1 PKNOX1 ARNT MLX WRNIP1 ARID4B GATA2 SP5 NCOA1 REST WBP1 TET3 ENSG00000273245 BOLA3 BOLA3-AS1 ACTG2 LOC107985899 DUSP11 MTHFD2 DGUOK-AS1
GH02F074028 1.2 Ensembl ENCODE 12.2 +48.2 48194 5.5 HDGF TBP ATF1 PKNOX1 TBL1XR1 ARNT WRNIP1 SIN3A YBX1 RFX5 TET3 FNBP1P1 DGUOK-AS1 ENSG00000279181
GH02F074053 0.9 Ensembl ENCODE 11.8 +70.5 70466 1.6 ESRRA MAFG EBF1 ZNF217 CTBP1 MAFF ZNF316 IKZF1 RCOR1 MAFK TET3 BOLA3 BOLA3-AS1 ACTG2 DGUOK-AS1 FNBP1P1 ENSG00000279181
GH02F073895 0.9 Ensembl ENCODE 10.4 -86.5 -86541 1.7 MTA2 REST EBF1 TBX21 EP300 IKZF1 NBN ZBTB33 MLLT1 DGUOK TET3 STAMBP BOLA3 BOLA3-AS1 TPRKB ALMS1-IT1 SMYD5 ACTG2 GC02M073905
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TET3 on UCSC Golden Path with GeneCards custom track

Promoters for TET3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001824202 1465 2401 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2
ENSR00001543676 -1935 801 TBP HDAC1 PKNOX1 TBL1XR1 CREB3L1 ZFP64 SIN3A ZNF48 RAD21 GLIS2

Genomic Location for TET3 Gene

Chromosome:
2
Start:
73,983,335 bp from pter
End:
74,108,176 bp from pter
Size:
124,842 bases
Orientation:
Plus strand

Genomic View for TET3 Gene

Genes around TET3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TET3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TET3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TET3 Gene

Proteins for TET3 Gene

  • Protein details for TET3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43151-TET3_HUMAN
    Recommended name:
    Methylcytosine dioxygenase TET3
    Protein Accession:
    O43151
    Secondary Accessions:
    • A6NEI3
    • Q86Z24
    • Q8TBM9

    Protein attributes for TET3 Gene

    Size:
    1660 amino acids
    Molecular mass:
    179350 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with HCFC1 and OGT.
    SequenceCaution:
    • Sequence=AAH22243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAX93057.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA23697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TET3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TET3 Gene

Selected DME Specific Peptides for TET3 Gene

O43151:
  • SLVFYQHK
  • GCPIAKWV
  • EEKLLCLVR

Post-translational modifications for TET3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TET3 Gene

Gene Families for TET3 Gene

Protein Domains for TET3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TET3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43151

UniProtKB/Swiss-Prot:

TET3_HUMAN :
  • Belongs to the TET family.
Family:
  • Belongs to the TET family.
genes like me logo Genes that share domains with TET3: view

Function for TET3 Gene

Molecular function for TET3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Enzyme Numbers (IUBMB) for TET3 Gene

Gene Ontology (GO) - Molecular Function for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000907 sulfonate dioxygenase activity IEA --
GO:0003677 DNA binding IEA --
GO:0005506 iron ion binding IBA --
GO:0005515 protein binding IPI 23222540
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TET3: view

Phenotypes for TET3 Gene

genes like me logo Genes that share phenotypes with TET3: view

Animal Models for TET3 Gene

MGI Knock Outs for TET3:

Animal Model Products

miRNA for TET3 Gene

miRTarBase miRNAs that target TET3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TET3 Gene

Localization for TET3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TET3 Gene

Nucleus. Cytoplasm. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TET3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA,ISS --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TET3: view

Pathways & Interactions for TET3 Gene

genes like me logo Genes that share pathways with TET3: view

Pathways by source for TET3 Gene

SIGNOR curated interactions for TET3 Gene

Activates:

Gene Ontology (GO) - Biological Process for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006211 5-methylcytosine catabolic process IBA --
GO:0006493 protein O-linked glycosylation IMP 23353889
GO:0007275 multicellular organism development IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0019511 peptidyl-proline hydroxylation IEA --
genes like me logo Genes that share ontologies with TET3: view

Drugs & Compounds for TET3 Gene

(2) Drugs for TET3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for TET3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with TET3: view

Transcripts for TET3 Gene

Unigene Clusters for TET3 Gene

Tet methylcytosine dioxygenase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TET3 Gene

No ASD Table

Relevant External Links for TET3 Gene

GeneLoc Exon Structure for
TET3
ECgene alternative splicing isoforms for
TET3

Expression for TET3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TET3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TET3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for TET3 Gene

This gene is overexpressed in Tlymphocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TET3 Gene



Protein tissue co-expression partners for TET3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TET3 Gene:

TET3

SOURCE GeneReport for Unigene cluster for TET3 Gene:

Hs.516107

mRNA Expression by UniProt/SwissProt for TET3 Gene:

O43151-TET3_HUMAN
Tissue specificity: Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with TET3: view

Primer Products

Orthologs for TET3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TET3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TET3 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia TET3 34 35
  • 91.75 (n)
cow
(Bos Taurus)
Mammalia LOC101904937 34
  • 91.62 (n)
TET3 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TET3 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tet3 34
  • 87.95 (n)
mouse
(Mus musculus)
Mammalia Tet3 34 16 35
  • 87.31 (n)
oppossum
(Monodelphis domestica)
Mammalia TET3 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TET3 34 35
  • 70.88 (n)
lizard
(Anolis carolinensis)
Reptilia TET3 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tet3 34
  • 58.21 (n)
Str.17563 34
zebrafish
(Danio rerio)
Actinopterygii LOC794865 34
  • 55.24 (n)
tet3 35
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43444 35
  • 10 (a)
OneToMany
Species where no ortholog for TET3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TET3 Gene

ENSEMBL:
Gene Tree for TET3 (if available)
TreeFam:
Gene Tree for TET3 (if available)

Paralogs for TET3 Gene

Paralogs for TET3 Gene

(2) SIMAP similar genes for TET3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TET3: view

Variants for TET3 Gene

Sequence variations from dbSNP and Humsavar for TET3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164943 -- 74,078,929(+) TTAGT(A/G)GCACC intron-variant
rs10165243 -- 74,008,429(+) GTCTC(C/T)TGTAG intron-variant
rs10166357 -- 74,003,529(+) ATCTG(C/T)AGAAA intron-variant
rs10168249 -- 74,016,326(+) aTTCA(A/G)TGGAC intron-variant
rs10168408 -- 74,016,469(+) gtaat(A/C)ctagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TET3 Gene

Variant ID Type Subtype PubMed ID
esv1001756 CNV insertion 20482838
esv1018075 CNV insertion 17803354
nsv954227 CNV deletion 24416366
nsv818048 CNV gain 17921354
nsv479007 CNV novel sequence insertion 20440878
nsv2782 CNV insertion 18451855
nsv1011177 CNV gain 25217958
esv3892681 CNV gain 25118596
esv3591276 CNV loss 21293372
esv3584956 CNV gain 24956385
esv28348 CNV loss 19812545
esv1346659 CNV insertion 17803354

Variation tolerance for TET3 Gene

Residual Variation Intolerance Score: 3.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TET3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TET3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TET3 Gene

Disorders for TET3 Gene

Relevant External Links for TET3

Genetic Association Database (GAD)
TET3
Human Genome Epidemiology (HuGE) Navigator
TET3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TET3

No disorders were found for TET3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TET3 Gene

Publications for TET3 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. (PMID: 23697932) Long H.K. … Klose R.J. (Biochem. Soc. Trans. 2013) 2 3 64
  3. TET2 promotes histone O-GlcNAcylation during gene transcription. (PMID: 23222540) Chen Q. … Yu X. (Nature 2013) 3 4 64
  4. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. (PMID: 23353889) Deplus R. … Fuks F. (EMBO J. 2013) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for TET3 Gene

Sources for TET3 Gene

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