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TET3 Gene

protein-coding   GIFtS: 50
GCID: GC02P074229

Tet Methylcytosine Dioxygenase 3

(Previous name: tet oncogene family member 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tet Methylcytosine Dioxygenase 31 2     Methylcytosine Dioxygenase TET32
Tet Oncogene Family Member 31 2     Probable Methylcytosine Dioxygenase TET32
EC 1.14.11.n23 8     Putative Methylcytosine Dioxygenase2
KIAA04013 5     

External Ids:    HGNC: 283131   Entrez Gene: 2004242   Ensembl: ENSG000001876057   OMIM: 6135555   UniProtKB: O431513   

Export aliases for TET3 gene to outside databases

Previous GC identifers: GC02P074127 GC02P074213 GC02P074009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TET3 Gene:
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation
process (Langemeijer et al., 2009 (PubMed 19923888)).(supplied by OMIM, Nov 2010)

GeneCards Summary for TET3 Gene:
TET3 (tet methylcytosine dioxygenase 3) is a protein-coding gene. GO annotations related to this gene include methylcytosine dioxygenase activity. An important paralog of this gene is TET2.

UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into
5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following
fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to
5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in
cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the
first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected
from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC
into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of
DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role
in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription
start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TET3 gene promoter:
         STAT1   AML1a   RREB-1   HFH-1   COMP1   Bach2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TET3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TET3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

TET3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TET3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074229:  view genomic region     (about GC identifiers)

Start:
74,229,840 bp from pter      End:
74,335,303 bp from pter
Size:
105,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TET3_HUMAN, O43151 (See protein sequence)
Recommended Name: Methylcytosine dioxygenase TET3  
Size: 1660 amino acids; 179350 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor: Binds 3 zinc ions per subunit. The zinc ions have a structural role (By similarity)
Subunit: Interacts with HCFC1 and OGT
Developmental stage: Expressed in fetal brain but not adult brain
Caution: Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine
demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by
unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is
rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG
Sequence caution: Sequence=AAH22243.1; Type=Erroneous initiation; Sequence=AAX93057.1; Type=Erroneous gene model
prediction; Sequence=BAA23697.1; Type=Erroneous initiation;
Secondary accessions: A6NEI3 Q86Z24 Q8TBM9
Alternative splicing: 3 isoforms:  O43151-1   O43151-2   O43151-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TET3: NX_O43151

Explore proteomics data for TET3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for TET3 (O43151)
     SLVFYQHK  GCPIAKWV  EEKLLCLVR 


    See TET3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001274420.1  
    ENSEMBL proteins: 
     ENSP00000307803   ENSP00000386869  
    Reactome Protein details: O43151

    TET3 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for TET3
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    Novus Biologicals TET3 Protein
    Novus Biologicals TET3 Lysate
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    Cloud-Clone Corp. Proteins for TET3

     
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    antibodies-online peptides for TET3

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    LSBio Antibodies in human, mouse, rat for TET3
    antibodies-online antibodies for TET3 (3 products) 

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    Cloud-Clone Corp. ELISAs for TET3
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024779 2OGFeDO_nucleic_acid_mod

    Graphical View of Domain Structure for InterPro Entry O43151

    ProtoNet protein and cluster: O43151

    UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
    Similarity: Belongs to the TET family


    Find genes that share domains with TET3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TET3_HUMAN, O43151
    Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into
    5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following
    fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to
    5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in
    cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the
    first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected
    from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC
    into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of
    DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role
    in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription
    start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT
    Catalytic activity: DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2)

         Enzyme Number (IUBMB): EC 1.14.11.n21 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
    GO:0070579methylcytosine dioxygenase activity ISS--
         
    Find genes that share ontologies with TET3           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tet3):
     cellular  other  reproductive system 

    Find genes that share phenotypes with TET3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tet3tm1.2Gxu for TET3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TET3
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    miRTarBase miRNAs that target TET3:
    hsa-mir-98-5p (MIRT027815), hsa-mir-548b-3p (MIRT016232), hsa-mir-26b-5p (MIRT030262)

    Block miRNA regulation of human, mouse, rat TET3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TET3 (see all 283):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-4275 hsa-miR-502-3p hsa-miR-637 hsa-miR-761 hsa-miR-3622a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TET3

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    Addgene plasmids for TET3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TET3_HUMAN, O43151: Nucleus (By similarity). Cytoplasm (By similarity). Note=At the zygotic stage, localizes in
    the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001939female pronucleus IEA--
    GO:0001940male pronucleus ISS--
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with TET3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with TET3           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for TET3
        TET1,2,3 and TDG demethylate DNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TET3
    Interactions:

        Search GeneGlobe Interaction Network for TET3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TET3 (ENSP000003078034) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPA1L2ENSP000003500904STRING: ENSP00000350090 STRING: ENSP00000341285
    YLPM1ENSP000003244634STRING: ENSP00000324463
    RBBP6ENSP000003178724STRING: ENSP00000317872
    SIN3AENSP000003536224STRING: ENSP00000353622
    COL4A1ENSP000003649794STRING: ENSP00000364979
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006493protein O-linked glycosylation IMP--
    GO:0044727DNA demethylation of male pronucleus ISS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP--
    GO:0080111DNA demethylation ISS--
    GO:0080182histone H3-K4 trimethylation IMP--

    Find genes that share ontologies with TET3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TET3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TET3 gene (2 alternative transcripts): 
    NM_144993.1  NM_001287491.1  

    Unigene Cluster for TET3:

    Tet methylcytosine dioxygenase 3
    Hs.516107  [show with all ESTs]
    Unigene Representative Sequence: NM_144993
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305799 ENST00000409262(uc010fez.2 uc002skb.4) ENST00000475405

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TET3 (see all 283):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-4275 hsa-miR-502-3p hsa-miR-637 hsa-miR-761 hsa-miR-3622a-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat TET3
      QuantiFast Probe-based Assays in human, mouse, rat TET3

    Additional mRNA sequence: 

    AB007861.1 AF466365.1 BC022243.1 HQ220209.1 

    5 DOTS entries:

    DT.443560  DT.91754787  DT.97823347  DT.120944723  DT.95262931 

    Selected AceView cDNA sequences (see all 69):

    BU633058 BM696034 AB007861 AL699130 AI560531 AL596858 CA425281 BC022243 
    AF466365 AI268419 BM698642 BQ637886 AW082364 BI260745 BM670735 BF981531 
    BI089673 BV197200 AI348471 R67098 CF264966 BX646350 AI690257 BM743232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TET3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCCAATT
    TET3 Expression
    About this image


    TET3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    TET3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TET3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516107

    UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
    Tissue specificity: Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TET3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tet31 , 5 tet methylcytosine dioxygenase 31, 5 87.31(n)1
    89.92(a)1
      6 (35.94 cM)5
    1943881  NM_183138.21  NP_898961.21 
     833623735 
    chicken
    (Gallus gallus)
    Aves TET31 tet oncogene family member 3 70.88(n)
    71.23(a)
      425829  XM_003642554.2  XP_003642602.2 
    lizard
    (Anolis carolinensis)
    Reptilia TET36
    tet methylcytosine dioxygenase 3
    52(a)
    1 ↔ 1
    GL343608.1(365838-386332)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175632 Transcribed sequence with moderate similarity to protein more 80.77(n)    BX757199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7948651 tet oncogene family member 3 55.24(n)
    51.18(a)
      794865  XM_005168616.1  XP_005168673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG434446
    --
    10(a)
    1 → many
    3L(2786206-2879158)


    ENSEMBL Gene Tree for TET3 (if available)
    TreeFam Gene Tree for TET3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TET3 gene
    TET22  TET12  
    2 SIMAP similar genes for TET3 using alignment to 4 protein entries:     TET3_HUMAN (see all proteins):
    CXXC4    TET2

    Find genes that share paralogs with TET3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TET3 (see all 1406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754194311,2
    F--74271564(+) GTACAT/CGATGT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1839908841,2
    --74271576(+) CCTCAA/GCTTAT 1 -- us2k10--------
    rs75688981,2
    C,F,A,H--74271577(+) ctcaaC/Tttatg 1 -- us2k110Minor allele frequency- T:0.17NS EA NA CSA WA 782
    rs1883808831,2
    --74271614(+) CATCAA/GTTGAA 1 -- us2k10--------
    rs1436716601,2
    --74271728(+) CAGTCA/GTTTAC 1 -- us2k10--------
    rs1913040171,2
    --74271742(+) GGTGAC/TGGCGT 1 -- us2k10--------
    rs1470614701,2
    --74271852(+) GCCTGC/TCGCAA 1 -- us2k10--------
    rs1477329081,2
    C--74271956(+) GGGCA-/TTCTCT 1 -- us2k10--------
    rs1842950441,2
    --74272055(+) GTCCCA/CAGTAA 1 -- us2k10--------
    rs1384216921,2
    C--74272156(+) ATTTCA/GAAGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TET3 (74229840 - 74335303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TET3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2782CNV Insertion18451855
    esv1346659CNV Insertion17803354
    nsv874286CNV Loss21882294
    esv28348CNV Loss19812545
    dgv4165n71CNV Gain21882294
    nsv818048CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TET3
    DNA2.0 Custom Variant and Variant Library Synthesis for TET3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613555    OMIM disorders: --


    Find genes that share disorders with TET3           About GenesLikeMe

    Genetic Association Database (GAD): TET3
    Human Genome Epidemiology (HuGE) Navigator: TET3 (3 documents)

    Export disorders for TET3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TET3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TET3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. (PubMed id 19420352)1, 4 Abdel-Wahab O.... Levine R.L. (Blood 2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. TET3-OGT interaction increases the stability and the presence of OGT in chromatin. (PubMed id 24304661)1 Ito R....Yokoyama A. (amp 2014)
    7. TET2 promotes histone O-GlcNAcylation during gene transcription. (PubMed id 23222540)2 Chen Q.... Yu X. (Nature 2013)
    8. Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a. (PubMed id 23820384)1 Zhang P....Sessa W.C. (Biochem. Biophys. Res. Commun. 2013)
    9. A mechanistic overview of TET-mediated 5-methylcytosine oxidation. (PubMed id 23727577)1 Ponnaluri V.K....Mukherji M. (Biochem. Biophys. Res. Commun. 2013)
    10. Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules. (PubMed id 23690950)1 Liu N....Spada F. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200424 HGNC: 28313 AceView: MGC22014 Ensembl:ENSG00000187605 euGenes: HUgn200424
    ECgene: TET3 H-InvDB: TET3

    (According to HUGE)
    About This Section

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    HUGE: KIAA0401

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TET3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TET3 gene:
    Search GeneIP for patents involving TET3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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