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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TET3 Gene

protein-coding   GIFtS: 48
GCID: GC02P074229

Tet Methylcytosine Dioxygenase 3

(Previous name: tet oncogene family member 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tet Methylcytosine Dioxygenase 31 2
Tet Oncogene Family Member 31 2
EC 1.14.11.n23 8
Methylcytosine Dioxygenase TET32
Probable Methylcytosine Dioxygenase TET32
KIAA04013

External Ids:    HGNC: 283131   Entrez Gene: 2004242   Ensembl: ENSG000001876057   OMIM: 6135555   UniProtKB: O431513   

Export aliases for TET3 gene to outside databases

Previous GC identifers: GC02P074127 GC02P074213 GC02P074009


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TET3 Gene:
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation
process (Langemeijer et al., 2009 (PubMed 19923888)).(supplied by OMIM, Nov 2010)

GeneCards Summary for TET3 Gene: 
TET3 (tet methylcytosine dioxygenase 3) is a protein-coding gene. Diseases associated with TET3 include acute myeloid leukemia, and myeloid leukemia. GO annotations related to this gene include methylcytosine dioxygenase activity and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. An important paralog of this gene is TET2.

UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into
5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following
fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to
5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in
cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the
first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected
from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC
into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of
DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role
in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription
start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TET3 gene promoter:
         STAT1   AML1a   RREB-1   HFH-1   COMP1   Bach2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TET3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TET3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

TET3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TET3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074229:  view genomic region     (about GC identifiers)

Start:
74,229,840 bp from pter      End:
74,335,303 bp from pter
Size:
105,464 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TET3_HUMAN, O43151 (See protein sequence)
Recommended Name: Methylcytosine dioxygenase TET3  
Size: 1660 amino acids; 179350 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with HCFC1 and OGT
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=At the zygotic stage, localizes in
the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages (By similarity)
Developmental stage: Expressed in fetal brain but not adult brain
Caution: Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine
demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by
unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is
rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG
Sequence caution: Sequence=AAH22243.1; Type=Erroneous initiation; Sequence=AAX93057.1; Type=Erroneous gene model
prediction; Sequence=BAA23697.1; Type=Erroneous initiation;
Secondary accessions: A6NEI3 Q86Z24 Q8TBM9
Alternative splicing: 3 isoforms:  O43151-1   O43151-2   O43151-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TET3: NX_O43151

Explore proteomics data for TET3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43151

  • 3 DME Specific Peptides for TET3 (O43151)
     SLVFYQHK  GCPIAKWV  EEKLLCLVR 

    TET3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TET3 Protein Expression
    REFSEQ proteins: NP_659430.1  
    ENSEMBL proteins: 
     ENSP00000307803   ENSP00000386869  

    Human Recombinant Protein Products for TET3: 
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    OriGene Custom Protein Services for TET3
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    Novus Biologicals TET3 Protein
    Novus Biologicals TET3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TET3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001939female pronucleus IEA--
    GO:0001940male pronucleus ISS--
    GO:0005737cytoplasm ISS--

    TET3 for ontologies           About GeneDecksing



    TET3 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for TET3 
    ThermoFisher Antibodies for TET3
    LSBio Antibodies in human, mouse, rat for TET3 

    Assay Products for TET3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TET3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TET3 
    Cloud-Clone Corp. CLIAs for TET3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024779 2OGFeDO_nucleic_acid_mod

    Graphical View of Domain Structure for InterPro Entry O43151

    ProtoNet protein and cluster: O43151

    UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
    Similarity: Belongs to the TET family


    TET3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TET3_HUMAN, O43151
    Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into
    5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following
    fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to
    5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in
    cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the
    first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected
    from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC
    into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of
    DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role
    in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription
    start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT
    Catalytic activity: DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2)

         Enzyme Number (IUBMB): EC 1.14.11.n21 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0046872metal ion binding IEA--
    GO:0070579methylcytosine dioxygenase activity ISS--
         
    TET3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tet3):
     cellular  other  reproductive system 

    TET3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tet3tm1.2Gxu for TET3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TET3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TET3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TET3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TET3 

    miRNA
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    8/283 QIAGEN miScript miRNA Assays for microRNAs that regulate TET3 (see all 283):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-4275 hsa-miR-502-3p hsa-miR-637 hsa-miR-761 hsa-miR-3622a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TET3 (see all 6)
    OriGene ORF clones in mouse, rat for TET3
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    GenScript: all cDNA clones in your preferred vector: TET3 (NM_144993)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TET3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TET3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TET3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TET3

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006493protein O-linked glycosylation IMP--
    GO:0044727DNA demethylation of male pronucleus ISS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP--
    GO:0080111DNA demethylation ISS--
    GO:0080182histone H3-K4 trimethylation IMP--

    TET3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TET3

    Search CenterWatch for drugs/clinical trials and news about TET3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TET3 gene: 
    NM_144993.1  

    Unigene Cluster for TET3:

    Tet methylcytosine dioxygenase 3
    Hs.516107  [show with all ESTs]
    Unigene Representative Sequence: NM_144993
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305799 ENST00000409262(uc010fez.2 uc002skb.4) ENST00000475405

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TET3
    8/283 QIAGEN miScript miRNA Assays for microRNAs that regulate TET3 (see all 283):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-4275 hsa-miR-502-3p hsa-miR-637 hsa-miR-761 hsa-miR-3622a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TET3
    Clone
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    GenScript: all cDNA clones in your preferred vector: TET3 (NM_144993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TET3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TET3
    Primer
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    OriGene qPCR primer pairs and template standards for TET3
    OriGene qSTAR qPCR primer pairs in human, mouse for TET3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TET3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TET3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TET3

    Additional mRNA sequence: 

    AB007861.1 AF466365.1 BC022243.1 HQ220209.1 

    5 DOTS entries:

    DT.443560  DT.91754787  DT.97823347  DT.120944723  DT.95262931 

    24/69 AceView cDNA sequences (see all 69):

    BM696034 BU633058 AB007861 AI560531 BC022243 AI268419 AL699130 AF466365 
    BM698642 CA425281 AL596858 BQ637886 AI348471 BM920394 BI260745 BX644462 
    BM743447 AI096702 BV197200 BX504050 CA419017 BM670735 BF981531 CF264966 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TET3 expression in normal human tissues (normalized intensities)      TET3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCCAATT
    TET3 Expression
    About this image


    TET3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle

    See TET3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TET3

    SOURCE GeneReport for Unigene cluster: Hs.516107

    UniProtKB/Swiss-Prot: TET3_HUMAN, O43151
    Tissue specificity: Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TET3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TET3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tet31 , 5 tet methylcytosine dioxygenase 31, 5 87.31(n)1
    89.92(a)1
      6 (35.94 cM)5
    1943881  NM_183138.21  NP_898961.21 
     833623735 
    chicken
    (Gallus gallus)
    Aves TET31 tet oncogene family member 3 69.46(n)
    69.17(a)
      425829  XM_003642554.1  XP_003642602.1 
    lizard
    (Anolis carolinensis)
    Reptilia TET36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343608.1(365838-386332)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175632 Transcribed sequence with moderate similarity to protein more 80.77(n)    BX757199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7948651 tet oncogene family member 3 54.64(n)
    50.39(a)
      794865  XM_003198607.1  XP_003198655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG434446
    --
    10(a)
    1 → many
    3L(2786206-2879158)


    ENSEMBL Gene Tree for TET3 (if available)
    TreeFam Gene Tree for TET3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TET3 gene
    TET22  TET12  
    2 SIMAP similar genes for TET3 using alignment to 4 protein entries:     TET3_HUMAN (see all proteins):
    CXXC4    TET2

    TET3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1406 SNPs in TET3 are shown (see all 1406)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754194311,2
    F--74271564(+) GTACAT/CGATGT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1839908841,2
    --74271576(+) CCTCAA/GCTTAT 1 -- us2k10--------
    rs75688981,2
    C,F,A,H--74271577(+) ctcaaC/Tttatg 1 -- us2k110Minor allele frequency- T:0.17NS EA NA CSA WA 782
    rs1883808831,2
    --74271614(+) CATCAA/GTTGAA 1 -- us2k10--------
    rs1436716601,2
    --74271728(+) CAGTCA/GTTTAC 1 -- us2k10--------
    rs1913040171,2
    --74271742(+) GGTGAC/TGGCGT 1 -- us2k10--------
    rs1470614701,2
    --74271852(+) GCCTGC/TCGCAA 1 -- us2k10--------
    rs1477329081,2
    C--74271956(+) GGGCA-/TTCTCT 1 -- us2k10--------
    rs1842950441,2
    --74272055(+) GTCCCA/CAGTAA 1 -- us2k10--------
    rs1384216921,2
    C--74272156(+) ATTTCA/GAAGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TET3 (74229840 - 74335303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TET3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2782CNV Insertion18451855
    esv1346659CNV Insertion17803354
    nsv874286CNV Loss21882294
    esv28348CNV Loss19812545
    dgv4165n71CNV Gain21882294
    nsv818048CNV Gain17921354

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613555    OMIM disorders: --

    3 diseases for TET3:    About MalaCards
    acute myeloid leukemia    myeloid leukemia    leukemia


    TET3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TET3
    Human Genome Epidemiology (HuGE) Navigator: TET3 (3 documents)

    Export disorders for TET3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TET3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TET3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. (PubMed id 19420352)1, 4 Abdel-Wahab O.... Levine R.L. (2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A mechanistic overview of TET-mediated 5-methylcytosin e oxidation. (PubMed id 23727577)1 Ponnaluri V.K....Mukherji M. (2013)
    7. TET2 promotes histone O-GlcNAcylation during gene transcription. (PubMed id 23222540)2 Chen Q.... Yu X. (2013)
    8. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lup us erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (2013)
    9. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. (PubMed id 23353889)2 Deplus R....Fuks F. (2013)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200424 HGNC: 28313 AceView: MGC22014 Ensembl:ENSG00000187605 euGenes: HUgn200424
    ECgene: TET3 H-InvDB: TET3

    (According to HUGE)
    About This Section
    HUGE: KIAA0401

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TET3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TET3 gene:
    Search GeneIP for patents involving TET3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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