Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TET3 Gene

Aliases for TET3 Gene

  • Tet Methylcytosine Dioxygenase 3 2 3
  • Tet Oncogene Family Member 3 2 3
  • EC 1.14.11.n2 4 63
  • KIAA0401 4 6
  • Probable Methylcytosine Dioxygenase TET3 3
  • Putative Methylcytosine Dioxygenase 3
  • Methylcytosine Dioxygenase TET3 3
  • HCG_40738 3

External Ids for TET3 Gene

Previous GeneCards Identifiers for TET3 Gene

  • GC02P074127
  • GC02P074213
  • GC02P074009
  • GC02P074229

Summaries for TET3 Gene

Entrez Gene Summary for TET3 Gene

  • Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TET3 Gene

TET3 (Tet Methylcytosine Dioxygenase 3) is a Protein Coding gene. GO annotations related to this gene include methylcytosine dioxygenase activity. An important paralog of this gene is TET2.

UniProtKB/Swiss-Prot for TET3 Gene

  • Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TET3 Gene

Genomics for TET3 Gene

Regulatory Elements for TET3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TET3 Gene

Start:
73,985,084 bp from pter
End:
74,108,176 bp from pter
Size:
123,093 bases
Orientation:
Plus strand

Genomic View for TET3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TET3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TET3 Gene

Proteins for TET3 Gene

  • Protein details for TET3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43151-TET3_HUMAN
    Recommended name:
    Methylcytosine dioxygenase TET3
    Protein Accession:
    O43151
    Secondary Accessions:
    • A6NEI3
    • Q86Z24
    • Q8TBM9

    Protein attributes for TET3 Gene

    Size:
    1660 amino acids
    Molecular mass:
    179350 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 3 zinc ions per subunit. The zinc ions have a structural role.;
    Quaternary structure:
    • Interacts with HCFC1 and OGT.
    SequenceCaution:
    • Sequence=AAH22243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAX93057.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA23697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TET3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TET3 Gene

Proteomics data for TET3 Gene at MOPED

Selected DME Specific Peptides for TET3 Gene

Post-translational modifications for TET3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TET3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TET3 Gene

Protein Domains for TET3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TET3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43151

UniProtKB/Swiss-Prot:

TET3_HUMAN :
  • O43151
Family:
  • Belongs to the TET family.
genes like me logo Genes that share domains with TET3: view

No data available for Gene Families for TET3 Gene

Function for TET3 Gene

Molecular function for TET3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2)
UniProtKB/Swiss-Prot Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Enzyme Numbers (IUBMB) for TET3 Gene

Gene Ontology (GO) - Molecular Function for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23222540
GO:0008270 zinc ion binding --
GO:0046872 metal ion binding IEA --
GO:0070579 methylcytosine dioxygenase activity ISS --
genes like me logo Genes that share ontologies with TET3: view

Phenotypes for TET3 Gene

genes like me logo Genes that share phenotypes with TET3: view

Animal Models for TET3 Gene

MGI Knock Outs for TET3:

Animal Model Products

CRISPR Products

miRNA for TET3 Gene

miRTarBase miRNAs that target TET3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TET3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TET3 Gene

Localization for TET3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TET3 Gene

Nucleus. Cytoplasm. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TET3 Gene COMPARTMENTS Subcellular localization image for TET3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TET3: view

Pathways for TET3 Gene

SuperPathways for TET3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TET3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation IMP 23353889
GO:0010467 gene expression TAS --
GO:0035511 oxidative DNA demethylation TAS --
GO:0040029 regulation of gene expression, epigenetic TAS --
GO:0044727 DNA demethylation of male pronucleus ISS --
genes like me logo Genes that share ontologies with TET3: view

No data available for Pathways by source for TET3 Gene

Transcripts for TET3 Gene

Unigene Clusters for TET3 Gene

Tet methylcytosine dioxygenase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TET3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TET3 Gene

No ASD Table

Relevant External Links for TET3 Gene

GeneLoc Exon Structure for
TET3
ECgene alternative splicing isoforms for
TET3

Expression for TET3 Gene

mRNA expression in normal human tissues for TET3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TET3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.2) and Skin - Sun Exposed (Lower leg) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TET3 Gene

SOURCE GeneReport for Unigene cluster for TET3 Gene Hs.516107

mRNA Expression by UniProt/SwissProt for TET3 Gene

O43151-TET3_HUMAN
Tissue specificity: Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.
genes like me logo Genes that share expressions with TET3: view

In Situ Assay Products

Orthologs for TET3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TET3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TET3 35
  • 99.56 (n)
  • 99.4 (a)
TET3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101904937 35
  • 91.62 (n)
  • 92 (a)
TET3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TET3 35
  • 91.75 (n)
  • 93.42 (a)
TET3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tet3 35
  • 87.31 (n)
  • 89.92 (a)
Tet3 16
Tet3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TET3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TET3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tet3 35
  • 87.95 (n)
  • 90.29 (a)
chicken
(Gallus gallus)
Aves TET3 35
  • 70.88 (n)
  • 71.23 (a)
TET3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TET3 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17563 35
tet3 35
  • 58.21 (n)
  • 57.11 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794865 35
  • 55.24 (n)
  • 51.18 (a)
tet3 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43444 36
  • 10 (a)
OneToMany
Species with no ortholog for TET3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TET3 Gene

ENSEMBL:
Gene Tree for TET3 (if available)
TreeFam:
Gene Tree for TET3 (if available)

Paralogs for TET3 Gene

Paralogs for TET3 Gene

Selected SIMAP similar genes for TET3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TET3: view

Variants for TET3 Gene

Sequence variations from dbSNP and Humsavar for TET3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs828867 -- 74,107,335(+) CGAGC(A/G)ATTTG utr-variant-3-prime
rs828868 -- 74,097,377(-) TATAC(A/G)ACTTG intron-variant
rs828869 -- 74,096,373(-) TATGG(C/T)ACTAA intron-variant
rs828870 -- 74,095,117(-) CCTTG(C/T)CTCGT intron-variant
rs828871 -- 74,088,950(-) gcatg(C/T)gtcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TET3 Gene

Variant ID Type Subtype PubMed ID
nsv818048 CNV Gain 17921354
nsv2782 CNV Insertion 18451855
dgv4165n71 CNV Gain 21882294
esv1346659 CNV Insertion 17803354
esv28348 CNV Loss 19812545
nsv874286 CNV Loss 21882294

Relevant External Links for TET3 Gene

HapMap Linkage Disequilibrium report
TET3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TET3 Gene

Disorders for TET3 Gene

Relevant External Links for TET3

Genetic Association Database (GAD)
TET3
Human Genome Epidemiology (HuGE) Navigator
TET3
genes like me logo Genes that share disorders with TET3: view

No data available for UniProtKB/Swiss-Prot for TET3 Gene

Publications for TET3 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. TET2 promotes histone O-GlcNAcylation during gene transcription. (PMID: 23222540) Chen Q. … Yu X. (Nature 2013) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. (PMID: 19420352) Abdel-Wahab O. … Levine R.L. (Blood 2009) 3 48

Products for TET3 Gene

  • Addgene plasmids for TET3

Sources for TET3 Gene

Back to Top

Content