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Aliases for TET1 Gene

Aliases for TET1 Gene

  • Tet Methylcytosine Dioxygenase 1 2 3
  • Leukemia-Associated Protein With A CXXC Domain 2 3 4
  • CXXC6 3 4 6
  • LCX 3 4 6
  • Ten-Eleven Translocation 1 Gene Protein 3 4
  • CXXC-Type Zinc Finger Protein 6 3 4
  • Ten-Eleven Translocation-1 2 3
  • CXXC Zinc Finger 6 2 3
  • Tet Oncogene 1 2 3
  • EC 1.14.11.n2 4 63
  • KIAA1676 4 6
  • Methylcytosine Dioxygenase TET1 3
  • TET1 Splice Variant VP_DE456 3
  • TET1 Splice Variant VP_DE4 3
  • CXXC Finger 6 3
  • BA119F7.1 3

External Ids for TET1 Gene

Previous HGNC Symbols for TET1 Gene

  • CXXC6

Previous GeneCards Identifiers for TET1 Gene

  • GC10P069991
  • GC10P070320
  • GC10P064321

Summaries for TET1 Gene

GeneCards Summary for TET1 Gene

TET1 (Tet Methylcytosine Dioxygenase 1) is a Protein Coding gene. Diseases associated with TET1 include leukemia. GO annotations related to this gene include iron ion binding and methylcytosine dioxygenase activity. An important paralog of this gene is TET2.

UniProtKB/Swiss-Prot for TET1 Gene

  • Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TET1 Gene

Genomics for TET1 Gene

Regulatory Elements for TET1 Gene

Genomic Location for TET1 Gene

Start:
68,560,360 bp from pter
End:
68,694,482 bp from pter
Size:
134,123 bases
Orientation:
Plus strand

Genomic View for TET1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TET1 Gene

Proteins for TET1 Gene

  • Protein details for TET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU7-TET1_HUMAN
    Recommended name:
    Methylcytosine dioxygenase TET1
    Protein Accession:
    Q8NFU7
    Secondary Accessions:
    • Q5VUP7
    • Q7Z6B6
    • Q8TCR1
    • Q9C0I7

    Protein attributes for TET1 Gene

    Size:
    2136 amino acids
    Molecular mass:
    235309 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 3 zinc ions per subunit. The zinc ions have a structural role.;
    Quaternary structure:
    • Interacts with HCFC1 and OGT (By similarity). Interacts with SIN3A; recruits the transcriptional corepressor SIN3A to gene promoters.
    SequenceCaution:
    • Sequence=CAD28467.3; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for TET1 Gene

Proteomics data for TET1 Gene at MOPED

Selected DME Specific Peptides for TET1 Gene

Post-translational modifications for TET1 Gene

  • Glycosylated. Interaction with OGT leads to GlcNAcylation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TET1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TET1 Gene

Protein Domains for TET1 Gene

Suggested Antigen Peptide Sequences for TET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFU7

UniProtKB/Swiss-Prot:

TET1_HUMAN :
  • Q8NFU7
Family:
  • Belongs to the TET family.
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with TET1: view

No data available for Gene Families for TET1 Gene

Function for TET1 Gene

Molecular function for TET1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2)
UniProtKB/Swiss-Prot CatalyticActivity: DNA 5-hydroxymethylcytosine + 2-oxoglutarate + O(2) = DNA 5-formylcytosine + succinate + CO(2)
UniProtKB/Swiss-Prot CatalyticActivity: DNA 5-formylcytosine + 2-oxoglutarate + O(2) = DNA 5-carboxylcytosine + succinate + CO(2)
UniProtKB/Swiss-Prot Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.

Enzyme Numbers (IUBMB) for TET1 Gene

Gene Ontology (GO) - Molecular Function for TET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005506 iron ion binding IDA 19372391
GO:0008270 zinc ion binding IEA --
GO:0043566 structure-specific DNA binding IDA 19372391
GO:0070579 methylcytosine dioxygenase activity IMP 21496894
genes like me logo Genes that share ontologies with TET1: view
genes like me logo Genes that share phenotypes with TET1: view

Animal Models for TET1 Gene

MGI Knock Outs for TET1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TET1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TET1 Gene

Localization for TET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TET1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TET1 Gene COMPARTMENTS Subcellular localization image for TET1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 19372391
genes like me logo Genes that share ontologies with TET1: view

Pathways for TET1 Gene

SuperPathways for TET1 Gene

No Data Available

Interacting Proteins for TET1 Gene

Gene Ontology (GO) - Biological Process for TET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001826 inner cell mass cell differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006493 protein O-linked glycosylation ISS --
GO:0010467 gene expression TAS --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with TET1: view

No data available for Pathways by source for TET1 Gene

Transcripts for TET1 Gene

Unigene Clusters for TET1 Gene

Tet methylcytosine dioxygenase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TET1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TET1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TET1 Gene

No ASD Table

Relevant External Links for TET1 Gene

GeneLoc Exon Structure for
TET1
ECgene alternative splicing isoforms for
TET1

Expression for TET1 Gene

mRNA expression in normal human tissues for TET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TET1 Gene

SOURCE GeneReport for Unigene cluster for TET1 Gene Hs.567594

mRNA Expression by UniProt/SwissProt for TET1 Gene

Q8NFU7-TET1_HUMAN
Tissue specificity: Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain.
genes like me logo Genes that share expressions with TET1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TET1 Gene

Orthologs for TET1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TET1 35
  • 99.59 (n)
  • 99.49 (a)
TET1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TET1 35
  • 83.54 (n)
  • 77.01 (a)
TET1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TET1 35
  • 85.95 (n)
  • 80.61 (a)
TET1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tet1 35
  • 70.05 (n)
  • 57.65 (a)
Tet1 16
Tet1 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TET1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TET1 36
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tet1 35
  • 70.94 (n)
  • 58.79 (a)
chicken
(Gallus gallus)
Aves TET1 35
  • 58.32 (n)
  • 46.95 (a)
TET1 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TET1 36
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tet1 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43444 36
  • 14 (a)
OneToMany
Species with no ortholog for TET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TET1 Gene

ENSEMBL:
Gene Tree for TET1 (if available)
TreeFam:
Gene Tree for TET1 (if available)

Paralogs for TET1 Gene

Paralogs for TET1 Gene

Selected SIMAP similar genes for TET1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TET1 Gene

genes like me logo Genes that share paralogs with TET1: view

Variants for TET1 Gene

Sequence variations from dbSNP and Humsavar for TET1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1747 -- 68,632,618(-) TTTGC(C/T)TTGCA intron-variant
rs949692 -- 68,594,701(+) AGAAC(A/G)GGCGC intron-variant
rs949693 -- 68,594,817(+) CTATT(A/G)AAAAT intron-variant
rs966578 -- 68,644,622(-) TAATA(A/G)CAACT intron-variant
rs1027506 -- 68,670,774(+) TTCAT(C/G)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TET1 Gene

Variant ID Type Subtype PubMed ID
esv2661103 CNV Deletion 23128226
nsv895693 CNV Loss 21882294
esv274213 CNV Insertion 20981092
nsv524412 CNV Loss 19592680
nsv510227 CNV Loss 20534489

Relevant External Links for TET1 Gene

HapMap Linkage Disequilibrium report
TET1
Human Gene Mutation Database (HGMD)
TET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TET1 Gene

Disorders for TET1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TET1 Gene including...

Search for TET1 Gene in MalaCards »

UniProtKB/Swiss-Prot

TET1_HUMAN
  • Note=A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with KMT2A/MLL1. This is a rare chromosomal translocation 5 KMT2A/MLL1-TET1 3.

Relevant External Links for TET1

Genetic Association Database (GAD)
TET1
Human Genome Epidemiology (HuGE) Navigator
TET1
genes like me logo Genes that share disorders with TET1: view

Publications for TET1 Gene

  1. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). (PMID: 12646957) Lorsbach R.B. … Downing J.R. (Leukemia 2003) 2 3 4
  2. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). (PMID: 12124344) Ono R. … Hayashi Y. (Cancer Res. 2002) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TET1 Gene

  • Addgene plasmids for TET1

Sources for TET1 Gene

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