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Aliases for TESPA1 Gene

Aliases for TESPA1 Gene

  • Thymocyte Expressed, Positive Selection Associated 1 2 3
  • KIAA0748 2 3 4 6
  • Thymocyte-Expressed Positive Selection-Associated Protein 1 3 4
  • Protein TESPA1 3
  • HSPC257 3

External Ids for TESPA1 Gene

Previous Symbols for TESPA1 Gene

  • KIAA0748

Summaries for TESPA1 Gene

GeneCards Summary for TESPA1 Gene

TESPA1 (Thymocyte Expressed, Positive Selection Associated 1) is a Protein Coding gene. An important paralog of this gene is SSFA2.

UniProtKB/Swiss-Prot for TESPA1 Gene

  • Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESPA1 Gene

Genomics for TESPA1 Gene

Genomic Location for TESPA1 Gene

Start:
54,948,018 bp from pter
End:
54,985,180 bp from pter
Size:
37,163 bases
Orientation:
Minus strand

Genomic View for TESPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TESPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESPA1 Gene

No data available for Regulatory Elements for TESPA1 Gene

Proteins for TESPA1 Gene

  • Protein details for TESPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU30-TESP1_HUMAN
    Recommended name:
    Protein TESPA1
    Protein Accession:
    A2RU30
    Secondary Accessions:
    • B4DPM3
    • B4E048
    • B7Z9K7
    • O94849
    • Q4G0P2
    • Q9P0C4

    Protein attributes for TESPA1 Gene

    Size:
    521 amino acids
    Molecular mass:
    59213 Da
    Quaternary structure:
    • Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome. Interacts with ITPR1. Also interacts with ITPR3 (By similarity). Interacts with HSPA9.
    SequenceCaution:
    • Sequence=AAF28935.1; Type=Frameshift; Positions=511; Evidence={ECO:0000305};

    Alternative splice isoforms for TESPA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESPA1 Gene

Proteomics data for TESPA1 Gene at MOPED

Post-translational modifications for TESPA1 Gene

  • May be phosphorylated in response to store-operated Ca(+2) entry.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys193, Lys289, and Lys308

No data available for DME Specific Peptides for TESPA1 Gene

Domains for TESPA1 Gene

Protein Domains for TESPA1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TESPA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TESPA1 Gene

Function for TESPA1 Gene

Molecular function for TESPA1 Gene

UniProtKB/Swiss-Prot Function: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.

Gene Ontology (GO) - Molecular Function for TESPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with TESPA1: view

Phenotypes for TESPA1 Gene

MGI mutant phenotypes for TESPA1:
inferred from 1 alleles
GenomeRNAi human phenotypes for TESPA1:
genes like me logo Genes that share phenotypes with TESPA1: view

Animal Models for TESPA1 Gene

MGI Knock Outs for TESPA1:

miRNA for TESPA1 Gene

miRTarBase miRNAs that target TESPA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TESPA1 Gene

Localization for TESPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESPA1 Gene

Cytoplasm. Endoplasmic reticulum membrane. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM).

Gene Ontology (GO) - Cellular Components for TESPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0008180 COP9 signalosome IDA 22561606
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TESPA1: view

Pathways for TESPA1 Gene

SuperPathways for TESPA1 Gene

No Data Available

Interacting Proteins for TESPA1 Gene

Gene Ontology (GO) - Biological Process for TESPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010387 COP9 signalosome assembly ISS --
GO:0033089 positive regulation of T cell differentiation in thymus ISS --
GO:0050862 positive regulation of T cell receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with TESPA1: view

No data available for Pathways by source for TESPA1 Gene

Transcripts for TESPA1 Gene

Unigene Clusters for TESPA1 Gene

Thymocyte expressed, positive selection associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TESPA1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - -
SP9: - -
SP10:
SP11:
SP12: - - - - - -

ExUns: 11a · 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TESPA1 Gene

GeneLoc Exon Structure for
TESPA1
ECgene alternative splicing isoforms for
TESPA1

Expression for TESPA1 Gene

mRNA expression in normal human tissues for TESPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TESPA1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (12.6), Brain - Cortex (12.5), Brain - Anterior cingulate cortex (BA24) (8.1), and Brain - Putamen (basal ganglia) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TESPA1 Gene

SOURCE GeneReport for Unigene cluster for TESPA1 Gene Hs.33187

genes like me logo Genes that share expressions with TESPA1: view

Orthologs for TESPA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TESPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TESPA1 36
  • 99.62 (n)
  • 99.62 (a)
TESPA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TESPA1 36
  • 86.07 (n)
  • 81.43 (a)
TESPA1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TESPA1 36
  • 86.48 (n)
  • 81.33 (a)
TESPA1 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tespa1 36
  • 79.54 (n)
  • 72.19 (a)
Tespa1 16
Tespa1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TESPA1 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TESPA1 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tespa1 36
  • 55.56 (n)
  • 43.72 (a)
zebrafish
(Danio rerio)
Actinopterygii tespa1 37
  • 25 (a)
OneToOne
Species with no ortholog for TESPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TESPA1 Gene

ENSEMBL:
Gene Tree for TESPA1 (if available)
TreeFam:
Gene Tree for TESPA1 (if available)

Paralogs for TESPA1 Gene

Paralogs for TESPA1 Gene

genes like me logo Genes that share paralogs with TESPA1: view

Variants for TESPA1 Gene

Sequence variations from dbSNP and Humsavar for TESPA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs960983 -- 54,950,980(-) TGACA(A/G)ATATT intron-variant
rs960984 -- 54,950,899(-) GAGAG(A/G)AAGTC intron-variant
rs960985 -- 54,951,151(-) CCTCC(C/T)ATGAG intron-variant
rs997173 - 54,961,249(+) CTCCT(C/T)CTCAC missense, reference
rs998401 -- 54,961,449(-) CCTCT(C/T)CTTGA intron-variant

Relevant External Links for TESPA1 Gene

HapMap Linkage Disequilibrium report
TESPA1

No data available for Structural Variations from Database of Genomic Variants (DGV) for TESPA1 Gene

Disorders for TESPA1 Gene

No disorders were found for TESPA1 Gene.

No data available for UniProtKB/Swiss-Prot for TESPA1 Gene

Publications for TESPA1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. (PMID: 22561606) Wang D. … Lu L. (Nat. Immunol. 2012) 3 4
  3. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. (PMID: 23501103) Matsuzaki H. … Shirasawa S. (Biochem. Biophys. Res. Commun. 2013) 3 4
  4. Tespa1 protein is phosphorylated in response to store-operated calcium entry. (PMID: 23541577) Fujimoto T. … Shirasawa S. (Biochem. Biophys. Res. Commun. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for TESPA1 Gene

Sources for TESPA1 Gene

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