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Aliases for TESPA1 Gene

Aliases for TESPA1 Gene

  • Thymocyte Expressed, Positive Selection Associated 1 2 3 5
  • KIAA0748 2 3 4
  • Thymocyte-Expressed Positive Selection-Associated Protein 1 3 4
  • HSPC257 3

External Ids for TESPA1 Gene

Previous HGNC Symbols for TESPA1 Gene

  • KIAA0748

Previous GeneCards Identifiers for TESPA1 Gene

  • GC12M055341

Summaries for TESPA1 Gene

GeneCards Summary for TESPA1 Gene

TESPA1 (Thymocyte Expressed, Positive Selection Associated 1) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is SSFA2.

UniProtKB/Swiss-Prot for TESPA1 Gene

  • Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESPA1 Gene

Genomics for TESPA1 Gene

Regulatory Elements for TESPA1 Gene

Enhancers for TESPA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TESPA1 on UCSC Golden Path with GeneCards custom track

Promoters for TESPA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TESPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TESPA1 Gene

Chromosome:
12
Start:
54,948,018 bp from pter
End:
54,985,161 bp from pter
Size:
37,144 bases
Orientation:
Minus strand

Genomic View for TESPA1 Gene

Genes around TESPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESPA1 Gene

Proteins for TESPA1 Gene

  • Protein details for TESPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU30-TESP1_HUMAN
    Recommended name:
    Protein TESPA1
    Protein Accession:
    A2RU30
    Secondary Accessions:
    • B4DPM3
    • B4E048
    • B7Z9K7
    • O94849
    • Q4G0P2
    • Q9P0C4

    Protein attributes for TESPA1 Gene

    Size:
    521 amino acids
    Molecular mass:
    59213 Da
    Quaternary structure:
    • Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome. Interacts with ITPR1. Also interacts with ITPR3 (By similarity). Interacts with HSPA9.
    SequenceCaution:
    • Sequence=AAF28935.1; Type=Frameshift; Positions=511; Evidence={ECO:0000305};

    Alternative splice isoforms for TESPA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESPA1 Gene

Proteomics data for TESPA1 Gene at MOPED

Post-translational modifications for TESPA1 Gene

  • May be phosphorylated in response to store-operated Ca(+2) entry.
  • Ubiquitination at Lys 13, Lys 193, Lys 289, and Lys 308
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TESPA1 Gene

Domains & Families for TESPA1 Gene

Protein Domains for TESPA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TESPA1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TESPA1 Gene

Function for TESPA1 Gene

Molecular function for TESPA1 Gene

UniProtKB/Swiss-Prot Function:
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
genes like me logo Genes that share phenotypes with TESPA1: view

Animal Models for TESPA1 Gene

MGI Knock Outs for TESPA1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TESPA1 Gene

Localization for TESPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESPA1 Gene

Cytoplasm. Endoplasmic reticulum membrane. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000269 PubMed:23501103}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TESPA1 Gene COMPARTMENTS Subcellular localization image for TESPA1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TESPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008180 COP9 signalosome IDA 22561606
genes like me logo Genes that share ontologies with TESPA1: view

Pathways & Interactions for TESPA1 Gene

SuperPathways for TESPA1 Gene

No Data Available

Interacting Proteins for TESPA1 Gene

Gene Ontology (GO) - Biological Process for TESPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010387 COP9 signalosome assembly ISS --
genes like me logo Genes that share ontologies with TESPA1: view

No data available for Pathways by source and SIGNOR curated interactions for TESPA1 Gene

Drugs & Compounds for TESPA1 Gene

No Compound Related Data Available

Transcripts for TESPA1 Gene

Unigene Clusters for TESPA1 Gene

Thymocyte expressed, positive selection associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TESPA1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - -
SP9: - -
SP10:
SP11:
SP12: - - - - - -

ExUns: 11a · 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TESPA1 Gene

GeneLoc Exon Structure for
TESPA1
ECgene alternative splicing isoforms for
TESPA1

Expression for TESPA1 Gene

mRNA expression in normal human tissues for TESPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TESPA1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.6), Brain - Cortex (x12.5), Brain - Anterior cingulate cortex (BA24) (x8.1), and Brain - Putamen (basal ganglia) (x4.9).

Protein differential expression in normal tissues from HIPED for TESPA1 Gene

This gene is overexpressed in Platelet (40.0), Frontal cortex (17.6), and CD4 Tcells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TESPA1 Gene



SOURCE GeneReport for Unigene cluster for TESPA1 Gene Hs.33187

genes like me logo Genes that share expression patterns with TESPA1: view

Protein tissue co-expression partners for TESPA1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TESPA1 Gene

Orthologs for TESPA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TESPA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TESPA1 35
  • 86.07 (n)
  • 81.43 (a)
TESPA1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TESPA1 35
  • 86.48 (n)
  • 81.33 (a)
TESPA1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tespa1 35
  • 79.54 (n)
  • 72.19 (a)
Tespa1 16
Tespa1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TESPA1 35
  • 99.62 (n)
  • 99.62 (a)
TESPA1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TESPA1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TESPA1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tespa1 35
  • 55.56 (n)
  • 43.72 (a)
zebrafish
(Danio rerio)
Actinopterygii tespa1 36
  • 25 (a)
OneToOne
Species with no ortholog for TESPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TESPA1 Gene

ENSEMBL:
Gene Tree for TESPA1 (if available)
TreeFam:
Gene Tree for TESPA1 (if available)

Paralogs for TESPA1 Gene

Paralogs for TESPA1 Gene

genes like me logo Genes that share paralogs with TESPA1: view

Variants for TESPA1 Gene

Sequence variations from dbSNP and Humsavar for TESPA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs997173 - 54,961,249(+) CTCCT(C/T)CTCAC nc-transcript-variant, reference, missense
rs2046686 -- 54,977,887(+) AGAGC(C/T)CTGTC intron-variant, utr-variant-5-prime
rs2046688 -- 54,969,809(+) ttgga(A/G)gcagg intron-variant
rs2046689 -- 54,970,089(+) GGCTA(A/G)TTTTA intron-variant
rs2046690 -- 54,970,131(+) TGGAG(G/T)ACTGG intron-variant

Variation tolerance for TESPA1 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.15; 93.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TESPA1 Gene

Disorders for TESPA1 Gene

Relevant External Links for TESPA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TESPA1

No disorders were found for TESPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESPA1 Gene

Publications for TESPA1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Tespa1 is associated with susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China. (PMID: 25736038) Yao Y. … Sun H. (Clin. Rheumatol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Lack of association between TESPA1 gene polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and ankylosing spondylitis in a Chinese population. (PMID: 24893580) Liu S. … Xin L. (Inflammation 2014) 3
  5. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. (PMID: 23501103) Matsuzaki H. … Shirasawa S. (Biochem. Biophys. Res. Commun. 2013) 3

Products for TESPA1 Gene

Sources for TESPA1 Gene

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