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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TESPA1 Gene

protein-coding   GIFtS: 36
GCID: GC12M055341

Thymocyte Expressed, Positive Selection Associated 1

(Previous name: KIAA0748)
(Previous symbol: KIAA0748)
  Search for TESPA1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thymocyte Expressed, Positive Selection Associated 11 2
KIAA07481 2 3
Thymocyte-Expressed Positive Selection-Associated Protein 12 3
Protein TESPA12

External Ids:    HGNC: 291091   Entrez Gene: 98402   Ensembl: ENSG000001354267   UniProtKB: A2RU303   

Export aliases for TESPA1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TESPA1 Gene: 
TESPA1 (thymocyte expressed, positive selection associated 1) is a protein-coding gene. An important paralog of this gene is CCDC129.

UniProtKB/Swiss-Prot: TESP1_HUMAN, A2RU30
Function: Required for the development and maturation of T-cells, its function being essential for the late stages
of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of
the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of
the LAT signalosome in thymocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TESPA1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TESPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TESPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

TESPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TESPA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M055341:  view genomic region     (about GC identifiers)

Start:
55,341,802 bp from pter      End:
55,378,530 bp from pter
Size:
36,729 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TESP1_HUMAN, A2RU30 (See protein sequence)
Recommended Name: Protein TESPA1  
Size: 521 amino acids; 59213 Da
Subunit: Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may
facilitate the assembly of the LAT signalosome
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF28935.1; Type=Frameshift; Positions=511;
Secondary accessions: B4DPM3 B4E048 B7Z9K7 O94849 Q4G0P2 Q9P0C4
Alternative splicing: 3 isoforms:  A2RU30-1   A2RU30-2   A2RU30-3   

Explore the universe of human proteins at neXtProt for TESPA1: NX_A2RU30

Explore proteomics data for TESPA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A2RU30

  • TESPA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TESPA1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001092285.1  NP_001129502.1  NP_001248773.1  NP_055611.1  

    ENSEMBL proteins: 
     ENSP00000435622   ENSP00000434811   ENSP00000436753   ENSP00000432030   ENSP00000400892  
     ENSP00000312679   ENSP00000436286   ENSP00000433098   ENSP00000433187   ENSP00000435734  
     ENSP00000434039   ENSP00000436635   ENSP00000433895  

    Human Recombinant Protein Products for TESPA1: 
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    OriGene Custom MassSpec 
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    Novus Biologicals TESPA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0008180COP9 signalosome IDA--

    TESPA1 for ontologies           About GeneDecksing



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    Assay Products for TESPA1: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026647 TESPA1

    Graphical View of Domain Structure for InterPro Entry A2RU30

    ProtoNet protein and cluster: A2RU30


    TESPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TESP1_HUMAN, A2RU30
    Function: Required for the development and maturation of T-cells, its function being essential for the late stages
    of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of
    the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of
    the LAT signalosome in thymocytes

    Phenotypes:
         1 GenomeRNAi human phenotype for TESPA1:

     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tespa1):
     cellular  hematopoietic system  immune system 

    TESPA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tespa1tm1Lrgl for TESPA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TESPA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TESPA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TESPA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TESPA1 

    miRNA
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                         Customized lentivirus expression plasmids for stable overexpression of TESPA1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESPA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TESPA1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010387COP9 signalosome assembly ISS--
    GO:0033089positive regulation of T cell differentiation in thymus ISS--
    GO:0050862positive regulation of T cell receptor signaling pathway ISS--

    TESPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TESPA1 (TESP1)

    Search CenterWatch for drugs/clinical trials and news about TESPA1 / TESP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TESPA1 gene (4 alternative transcripts): 
    NM_001098815.2  NM_001136030.2  NM_001261844.1  NM_014796.2  

    Unigene Cluster for TESPA1:

    Thymocyte expressed, positive selection associated 1
    Hs.33187  [show with all ESTs]
    Unigene Representative Sequence: AB018291
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524622(uc001sgl.3 uc010spc.1) ENST00000524923(uc010spb.1)
    ENST00000528240 ENST00000532804(uc001sgm.3) ENST00000449076(uc001sgn.3 uc010spd.1)
    ENST00000316577 ENST00000532757 ENST00000531122 ENST00000524959 ENST00000526532
    ENST00000533446 ENST00000525978 ENST00000524668 ENST00000533607
    miRNA
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    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of TESPA1 
                         Customized lentivirus expression plasmids for stable overexpression of TESPA1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TESPA1
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    Additional mRNA sequence: 

    AB018291.1 AF161375.1 AK295026.1 AK298405.1 AK303223.1 AK315972.1 BC037220.1 BC044578.1 
    BC132732.1 BC132734.1 

    11 DOTS entries:

    DT.206275  DT.121200047  DT.121200032  DT.91677876  DT.121200028  DT.100757847  DT.121200035  DT.121200037 
    DT.121200041  DT.121200044  DT.95200418 

    24/72 AceView cDNA sequences (see all 72):

    AA354573 BX481720 BX497991 CR600998 AA355649 BP349489 AA984688 AA354038 
    BG219833 AI685435 BQ338472 BI550778 Z39735 BU631858 AB018291 AW962076 
    BC044578 AI124711 BX421586 BP349560 CA432504 BC037220 N73327 BI824345 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TESPA1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^
    SP1:                                                              -     -     -                                                                                 
    SP2:              -     -     -     -     -     -                 -     -     -                                                                                 
    SP3:                                -     -     -                 -     -     -                                                                                 
    SP4:                                                              -     -     -                                         -     -                                 
    SP5:                                                              -     -     -                                                     -     -     -     -     -   

    ExUns: 11a · 11b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for TESPA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TESPA1 expression in normal human tissues (normalized intensities)      TESPA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TESPA1 Expression
    About this image


    TESPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose

    See TESPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TESPA1

    SOURCE GeneReport for Unigene cluster: Hs.33187
        SABiosciences Custom PCR Arrays for TESPA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TESPA1 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tespa11 , 5 thymocyte expressed, positive selection associated more1, 5 79.54(n)1
    72.19(a)1
      10 (77.85 cM)5
    675961  NM_183264.41  NP_899087.21 
     1303228525 
    lizard
    (Anolis carolinensis)
    Reptilia TESPA16
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343252.1(1021060-1023597)
    zebrafish
    (Danio rerio)
    Actinopterygii TESPA16
    thymocyte expressed, positive selection associated...
    18(a)
    1 ↔ 1
    6(46639027-46661430)


    ENSEMBL Gene Tree for TESPA1 (if available)
    TreeFam Gene Tree for TESPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TESPA1 gene
    CCDC1292  SSFA22  

    TESPA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/939 SNPs in TESPA1 are shown (see all 939)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003828691,2
    Cuntested155355015(+) CCAGCA/GACTCT 8 R C mis10--------
    rs1874545321,2
    --55341649(+) GGCTGG/TTTCAT 4 -- ds50010--------
    rs79583671,2
    C,F,H--55341650(+) gctggT/Atcatc 4 -- ds50013Minor allele frequency- A:0.00EA NS 276
    rs1903684761,2
    --55341658(+) ATCGGA/GGGACC 4 -- ds50010--------
    rs123184231,2
    C--55341670(+) gaggtC/Tgtagg 4 -- ds50013Minor allele frequency- T:0.06NA 124
    rs776267141,2
    C--55341699(+) TAAAGA/GGCAGA 4 -- ds50012Minor allele frequency- G:0.25WA 4
    rs1836024671,2
    --55341725(+) TCTCCC/TCAGGG 4 -- ds50010--------
    rs1880927721,2
    --55341726(+) CTCCCA/CAGGGA 4 -- ds50010--------
    rs1929128021,2
    --55341743(+) CCGATC/TGAAGT 4 -- ds50010--------
    rs1845236541,2
    --55341744(+) CGATCA/GAAGTC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for TESPA1 (55341802 - 55378530 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TESPA1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TESPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for TESPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TESPA1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TESPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Tespa1 protein is phosphorylated in response to store- operated calcium entry. (PubMed id 23541577)1 Fujimoto T....Shirasawa S. (2013)
    3. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. (PubMed id 23501103)1 Matsuzaki H....Shirasawa S. (2013)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. (PubMed id 22561606)2 Wang D.... Lu L. (2012)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9840 HGNC: 29109 AceView: KIAA0748 Ensembl:ENSG00000135426 euGenes: HUgn9840
    ECgene: TESPA1 H-InvDB: TESPA1

    (According to HUGE)
    About This Section
    HUGE: KIAA0748

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TESPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TESPA1 gene:
    Search GeneIP for patents involving TESPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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