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TESMIN Gene(Protein Coding)

Testis Expressed Metallothionein Like Protein

GCID:
GC11M068706
GIFtS:
34
Genes Participants
UDN Logo

Aliases for TESMIN Gene

Aliases for TESMIN Gene

  • Testis Expressed Metallothionein Like Protein 2
  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3 5
  • MTL5 3 4 5
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • MTLT 3

External Ids for TESMIN Gene

Previous HGNC Symbols for TESMIN Gene

  • MTL5

Summaries for TESMIN Gene

Entrez Gene Summary for TESMIN Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TESMIN Gene

TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot for TESMIN Gene

  • May have a role in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESMIN Gene

Genomics for TESMIN Gene

Products:

  1. Regulatory Element

Regulatory Elements for TESMIN Gene

Enhancers for TESMIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TESMIN on UCSC Golden Path with GeneCards custom track

Promoters for TESMIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TESMIN on UCSC Golden Path with GeneCards custom track

Genomic Location for TESMIN Gene

Chromosome:
11
Start:
68,706,674 bp from pter
End:
68,751,564 bp from pter
Size:
44,891 bases
Orientation:
Minus strand

Genomic View for TESMIN Gene

Genes around TESMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESMIN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TESMIN Gene

Proteins for TESMIN Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4I5-MTL5_HUMAN
    Recommended name:
    Tesmin
    Protein Accession:
    Q9Y4I5
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for TESMIN Gene

    Size:
    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for TESMIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESMIN Gene

Proteomics data for TESMIN Gene at MOPED

Post-translational modifications for TESMIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TESMIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TESMIN Gene

Domains & Families for TESMIN Gene

Protein Domains for TESMIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TESMIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4I5

UniProtKB/Swiss-Prot:

MTL5_HUMAN :
  • Contains 1 CRC domain.
  • Belongs to the lin-54 family.
Domain:
  • Contains 1 CRC domain.
Family:
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with TESMIN: view

No data available for Gene Families for TESMIN Gene

Function for TESMIN Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TESMIN Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Phenotypes for TESMIN Gene

GenomeRNAi human phenotypes for TESMIN:
genes like me logo Genes that share phenotypes with TESMIN: view

Animal Model Products

miRNA for TESMIN Gene

miRTarBase miRNAs that target TESMIN

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene

Localization for TESMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene

Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TESMIN Gene

Pathways & Interactions for TESMIN Gene

SuperPathways for TESMIN Gene

PathCards logoMore details on SuperPathways for TESMIN
No Data Available

Interacting Proteins for TESMIN Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255087%0d%0a9606.ENSP00000387982%0d%0a9606.ENSP00000362592%0d%0a9606.ENSP00000262144%0d%0a9606.ENSP00000369424%0d%0a9606.ENSP00000329102%0d%0a
Selected Interacting proteins: ENSP00000255087 for TESMIN Gene via STRING

Gene Ontology (GO) - Biological Process for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene

Drugs & Compounds for TESMIN Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TESMIN Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TESMIN Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TESMIN Gene

Metallothionein-like 5, testis-specific (tesmin):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESMIN Gene

No ASD Table

Relevant External Links for TESMIN Gene

GeneLoc Exon Structure for
TESMIN
ECgene alternative splicing isoforms for
TESMIN

Expression for TESMIN Gene

Products:

  1. Primer

SOURCE GeneReport for Unigene cluster for TESMIN Gene Hs.145932

mRNA Expression by UniProt/SwissProt for TESMIN Gene

Q9Y4I5-MTL5_HUMAN
Tissue specificity: Expressed specifically in testis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TESMIN Gene

Orthologs for TESMIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TESMIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia MTL5 35
  • 84.48 (n)
  • 80.28 (a)
dog
(Canis familiaris)
 Mammalia MTL5 35
  • 83.66 (n)
  • 80.71 (a)
MTL5 36
  • 78 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mtl5 35
  • 73.35 (n)
  • 68.14 (a)
Mtl5 16
Mtl5 36
  • 68 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia MTL5 35
  • 99.21 (n)
  • 98.23 (a)
MTL5 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mtl5 35
  • 72.86 (n)
  • 67.3 (a)
oppossum
(Monodelphis domestica)
 Mammalia MTL5 36
  • 47 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MTL5 36
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MTL5 35
  • 65.4 (n)
  • 54.23 (a)
MTL5 36
  • 36 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MTL5 36
  • 61 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5658 35
zebrafish
(Danio rerio)
 Actinopterygii MTL5 36
  • 24 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta mip120 36
  • 11 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea lin-54 36
  • 23 (a)
 OneToMany
Species with no ortholog for TESMIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TESMIN Gene

ENSEMBL:
Gene Tree for TESMIN (if available)
TreeFam:
Gene Tree for TESMIN (if available)

Paralogs for TESMIN Gene

Paralogs for TESMIN Gene

genes like me logo Genes that share paralogs with TESMIN: view

Variants for TESMIN Gene

Sequence variations from dbSNP and Humsavar for TESMIN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7119030 -- 68,718,455(+) agaag(A/G)tatga intron-variant
rs7119788 -- 68,737,775(+) tggta(C/T)agtgg intron-variant, utr-variant-3-prime
rs7119793 -- 68,737,794(+) TGTGG(G/T)CCCAG intron-variant, utr-variant-3-prime
rs7120966 -- 68,706,988(+) CTGTT(C/T)GCCGC downstream-variant-500B, utr-variant-3-prime
rs7121127 -- 68,741,996(+) AGGAG(C/T)GTTCT intron-variant

Variation tolerance for TESMIN Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TESMIN Gene

HapMap Linkage Disequilibrium report
TESMIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TESMIN Gene

Disorders for TESMIN Gene

Relevant External Links for TESMIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TESMIN

No disorders were found for TESMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene

Publications for TESMIN Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T. … Mitsui Y. (Genomics 1999) 3 4 23 67
  2. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. Tesmin transcription is regulated differently during male and female meiosis. (PMID: 14648882) Olesen C. … Byskov A.G. (Mol. Reprod. Dev. 2004) 3
  5. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. (PMID: 12606435) Sutou S. … Mitsui Y. (Biol. Reprod. 2003) 3

Products for TESMIN Gene

Sources for TESMIN Gene

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