Aliases for TESMIN Gene
Aliases for TESMIN Gene
External Ids for TESMIN Gene
- HGNC: 7446
- Entrez Gene: 9633
- Ensembl: ENSG00000132749
- OMIM: 604374
- UniProtKB: Q9Y4I5
Previous HGNC Symbols for TESMIN Gene
- MTL5
Summaries for TESMIN Gene
-
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TESMIN Gene
TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.
UniProtKB/Swiss-Prot for TESMIN Gene
-
May have a role in spermatogenesis.
Additional gene information for TESMIN Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESMIN Gene
Genomics for TESMIN Gene
GeneHancer (GH) Regulatory Elements for TESMIN Gene
Promoters and enhancers for TESMIN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TESMIN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TESMIN Gene
Genomic Locations for TESMIN Gene
- chr11:68,706,674-68,751,564
- (GRCh38/hg38)
- Size:
- 44,891 bases
- Orientation:
- Minus strand
- chr11:68,474,908-68,519,032
- (GRCh37/hg19)
Genomic View for TESMIN Gene
Genes around TESMIN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.3 by Ensembl
- 11q13.3 by Entrez Gene
- 11q13.3 by HGNC
TESMIN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TESMIN Gene
Proteins for TESMIN Gene
-
Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4I5-MTL5_HUMAN
- Recommended name:
- Tesmin
- Protein Accession:
- Q9Y4I5
- A8K8J3
- Q4G182
- Q6P2E2
- Q8NCC8
Protein attributes for TESMIN Gene
- Size:
- 508 amino acids
- Molecular mass:
- 55025 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Post-translational modifications for TESMIN Gene
No Post-translational modifications
Other Protein References for TESMIN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TESMIN
- Novus Biologicals Antibodies for TESMIN
- Invitrogen Antibodies for TESMIN
- GeneTex TESMIN antibody for TESMIN
Protein Products
-
OriGene Purified Proteins for TESMIN
- Search Origene for MassSpec and Protein Over-expression Lysates for TESMIN
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- antibodies-online: Search results for 4 available MTL5 Proteins ranked by validation data
- Compare Top MTL5 Proteins
-
Quality Products:
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-
Abcam proteins for TESMIN
Assay Products
- antibodies-online: Search results for 6 available MTL5 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for TESMIN Gene
Domains & Families for TESMIN Gene
Gene Families for TESMIN Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TESMIN Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TESMIN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y4I5- Family:
-
- Belongs to the lin-54 family.
Function for TESMIN Gene
Molecular function for TESMIN Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in spermatogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | NAS | 10191092 |
Phenotypes for TESMIN Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for TESMIN gene
-
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CRISPR Products
-
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- genomics-online: gRNA clones - Search results for 99 available MTL5 gene related products
- Overview of 99 available MTL5 gene related products
- Applied Biological Materials CRISPR for TESMIN
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for TESMIN
miRNA for TESMIN Gene
- miRTarBase miRNAs that target TESMIN
-
- hsa-mir-378a-5p (MIRT043976)
- hsa-mir-6513-5p (MIRT630012)
- hsa-mir-887-5p (MIRT630013)
- hsa-mir-3913-5p (MIRT630014)
- hsa-mir-3122 (MIRT630015)
- hsa-mir-450a-1-3p (MIRT630016)
- hsa-mir-6780a-5p (MIRT630017)
- hsa-mir-6779-5p (MIRT630018)
- hsa-mir-3689c (MIRT630019)
- hsa-mir-3689b-3p (MIRT630020)
- hsa-mir-3689a-3p (MIRT630021)
- hsa-mir-30b-3p (MIRT630022)
- hsa-mir-1273h-5p (MIRT630023)
- hsa-mir-6788-5p (MIRT630024)
- hsa-mir-30c-2-3p (MIRT630025)
- hsa-mir-30c-1-3p (MIRT630026)
- hsa-mir-7977 (MIRT630027)
- hsa-mir-6799-5p (MIRT630028)
- hsa-mir-6883-5p (MIRT630029)
- hsa-mir-6785-5p (MIRT630030)
- hsa-mir-4728-5p (MIRT630031)
- hsa-mir-149-3p (MIRT630032)
- hsa-mir-7106-5p (MIRT630033)
- hsa-mir-24-3p (MIRT630034)
- hsa-mir-4284 (MIRT630035)
- hsa-mir-9-5p (MIRT630036)
- hsa-mir-4267 (MIRT630037)
- hsa-mir-629-3p (MIRT650077)
- hsa-mir-6780b-5p (MIRT650078)
- hsa-mir-4725-3p (MIRT650079)
- hsa-mir-4271 (MIRT650080)
- hsa-mir-627-3p (MIRT650081)
- hsa-mir-134-3p (MIRT650082)
- hsa-mir-7114-5p (MIRT650083)
- hsa-mir-622 (MIRT650084)
miRNA Products
- Search ViGene Biosciences for TESMIN
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TESMIN
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- genomics-online: shRNA clones - Search results for 99 available MTL5 gene related products
- Overview of 99 available MTL5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TESMIN
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TESMIN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TESMIN
-
ViGene Biosciences adenoviral particle packaged cDNA for TESMIN gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene
Localization for TESMIN Gene
Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene
- Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for TESMIN Gene
No Data Available
Interacting Proteins for TESMIN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006875 | cellular metal ion homeostasis | NAS | 10191092 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | NAS | 10191092 |
| GO:0010038 | response to metal ion | NAS | 10191092 |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene
Drugs & Compounds for TESMIN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Carrier, binder | 202 |
Transcripts for TESMIN Gene
mRNA/cDNA for TESMIN Gene
- (5) REFSEQ mRNAs :
- (80) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TESMIN
- genomics-online: gRNA clones - Search results for 99 available MTL5 gene related products
- Overview of 99 available MTL5 gene related products
- Applied Biological Materials CRISPR for TESMIN
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for TESMIN
miRNA Products
- Search ViGene Biosciences for TESMIN
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TESMIN
- Browse OriGene Inhibitory RNA Products For TESMIN
- genomics-online: shRNA clones - Search results for 99 available MTL5 gene related products
- Overview of 99 available MTL5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TESMIN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TESMIN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TESMIN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TESMIN Gene
NURSA nuclear receptor signaling pathways regulating expression of TESMIN Gene:
TESMINmRNA Expression by UniProt/SwissProt for TESMIN Gene:
Q9Y4I5-MTL5_HUMAN
Tissue specificity:
Expressed specifically in testis.
Evidence on tissue expression from TISSUES for TESMIN Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TESMIN
-
OriGene qPCR primer pairs for TESMIN
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESMIN Gene
Orthologs for TESMIN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTL5 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MTL5 33 |
|
||
| dog (Canis familiaris) |
Mammalia | MTL5 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtl5 33 34 |
|
||
| Tesmin 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Mtl5 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTL5 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MTL5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTL5 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTL5 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | MTL5 34 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5658 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mip120 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | lin-54 34 |
|
OneToMany |
- Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TESMIN Gene
Variants for TESMIN Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026241 | -- | 68,708,204(-) | C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000035724 | -- | 68,745,480(-) | G/A | intron_variant | |
| rs1000040954 | -- | 68,712,052(-) | G/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000100605 | -- | 68,737,150(-) | C/T | 3_prime_UTR_variant, intron_variant | |
| rs1000160741 | -- | 68,742,889(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv670n106 | CNV | deletion | 24896259 |
| esv2744665 | CNV | deletion | 23290073 |
| esv2744666 | CNV | deletion | 23290073 |
| nsv1070468 | CNV | deletion | 25765185 |
| nsv509422 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.45;
64.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TESMIN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TESMIN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene
Disorders for TESMIN Gene
Additional Disease Information for TESMIN
No disorders were found for TESMIN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene
Publications for TESMIN Gene
- A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T … Mitsui Y (Genomics 1999) 3 4 22 58
- Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A … Wigdahl B (Journal of neurovirology 2013) 3 58
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 4 58
- Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
- Tesmin transcription is regulated differently during male and female meiosis. (PMID: 14648882) Olesen C … Byskov AG (Molecular reproduction and development 2004) 3 58
Products for TESMIN Gene
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- Invitrogen Antibodies for TESMIN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TESMIN
- VectorBuilder custom plasmid, inducible vectors for TESMIN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TESMIN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 30 available MTL5 Antibodies ranked by validation data
- Compare Top MTL5 Antibodies
- antibodies-online: Search results for 6 available MTL5 Elisa Kits ranked by validation data
- Compare Top MTL5 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available MTL5 Proteins ranked by validation data
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- Quality Products:
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- genomics-online: cdna clones - Search results for 99 available MTL5 gene related products
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Sources for TESMIN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
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