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Aliases for TESMIN Gene

Aliases for TESMIN Gene

  • Testis Expressed Metallothionein Like Protein 2 3 5
  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • MTL5 3 4
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • Tesmin 3
  • MTLT 3

External Ids for TESMIN Gene

Previous HGNC Symbols for TESMIN Gene

  • MTL5

Summaries for TESMIN Gene

Entrez Gene Summary for TESMIN Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TESMIN Gene

TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot for TESMIN Gene

  • May have a role in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESMIN Gene

Genomics for TESMIN Gene

Regulatory Elements for TESMIN Gene

Enhancers for TESMIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TESMIN on UCSC Golden Path with GeneCards custom track

Promoters for TESMIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TESMIN Gene

68,706,674 bp from pter
68,751,564 bp from pter
44,891 bases
Minus strand

Genomic View for TESMIN Gene

Genes around TESMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESMIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESMIN Gene

Proteins for TESMIN Gene

  • Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for TESMIN Gene

    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for TESMIN Gene


neXtProt entry for TESMIN Gene

Post-translational modifications for TESMIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TESMIN Gene

No data available for DME Specific Peptides for TESMIN Gene

Domains & Families for TESMIN Gene

Protein Domains for TESMIN Gene

Suggested Antigen Peptide Sequences for TESMIN Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRC domain.
  • Belongs to the lin-54 family.
  • Contains 1 CRC domain.
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with TESMIN: view

No data available for Gene Families for TESMIN Gene

Function for TESMIN Gene

Molecular function for TESMIN Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view
genes like me logo Genes that share phenotypes with TESMIN: view

Animal Model Products

miRNA for TESMIN Gene

miRTarBase miRNAs that target TESMIN

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene

Localization for TESMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene

Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.

Gene Ontology (GO) - Cellular Components for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Subcellular locations from COMPARTMENTS for TESMIN Gene

Pathways & Interactions for TESMIN Gene

SuperPathways for TESMIN Gene

No Data Available

Interacting Proteins for TESMIN Gene

Gene Ontology (GO) - Biological Process for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene

Drugs & Compounds for TESMIN Gene

No Compound Related Data Available

Transcripts for TESMIN Gene

Unigene Clusters for TESMIN Gene

Metallothionein-like 5, testis-specific (tesmin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESMIN Gene

No ASD Table

Relevant External Links for TESMIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TESMIN Gene

NURSA nuclear receptor signaling pathways regulating expression of TESMIN Gene:


SOURCE GeneReport for Unigene cluster for TESMIN Gene:


mRNA Expression by UniProt/SwissProt for TESMIN Gene:

Tissue specificity: Expressed specifically in testis.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TESMIN Gene

Orthologs for TESMIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TESMIN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTL5 35
  • 98 (a)
MTL5 34
  • 99.21 (n)
  • 98.23 (a)
(Ornithorhynchus anatinus)
Mammalia MTL5 35
  • 69 (a)
(Mus musculus)
Mammalia Mtl5 35
  • 68 (a)
Mtl5 16
Mtl5 34
  • 73.35 (n)
  • 68.14 (a)
(Monodelphis domestica)
Mammalia MTL5 35
  • 47 (a)
(Canis familiaris)
Mammalia MTL5 35
  • 78 (a)
MTL5 34
  • 83.66 (n)
  • 80.71 (a)
(Rattus norvegicus)
Mammalia Mtl5 34
  • 72.86 (n)
  • 67.3 (a)
(Bos Taurus)
Mammalia MTL5 34
  • 84.48 (n)
  • 80.28 (a)
(Gallus gallus)
Aves MTL5 35
  • 36 (a)
MTL5 34
  • 65.4 (n)
  • 54.23 (a)
(Anolis carolinensis)
Reptilia MTL5 35
  • 61 (a)
(Danio rerio)
Actinopterygii MTL5 35
  • 24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 34
fruit fly
(Drosophila melanogaster)
Insecta mip120 35
  • 11 (a)
(Caenorhabditis elegans)
Secernentea lin-54 35
  • 23 (a)
Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TESMIN Gene

Gene Tree for TESMIN (if available)
Gene Tree for TESMIN (if available)

Paralogs for TESMIN Gene

Paralogs for TESMIN Gene

genes like me logo Genes that share paralogs with TESMIN: view

Variants for TESMIN Gene

Sequence variations from dbSNP and Humsavar for TESMIN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12365708 - 68,745,075(+) TATAC(A/G)TAGCA intron-variant, reference, missense
rs35773957 - 68,742,367(+) TCCCT(A/G)CTAAA nc-transcript-variant, reference, missense
rs7942697 -- 68,727,994(+) tgact(G/T)ctcca intron-variant
rs7946887 -- 68,707,959(+) TCTCC(A/G)CAGGG intron-variant, utr-variant-3-prime
rs7947787 -- 68,725,641(+) TTTTT(G/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TESMIN Gene

Variant ID Type Subtype PubMed ID
dgv670n106 CNV deletion 24896259
esv2744665 CNV deletion 23290073
esv2744666 CNV deletion 23290073
nsv1070468 CNV deletion 25765185
nsv509422 CNV insertion 20534489

Variation tolerance for TESMIN Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TESMIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene

Disorders for TESMIN Gene

Relevant External Links for TESMIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TESMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene

Publications for TESMIN Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T. … Mitsui Y. (Genomics 1999) 3 4 22 65
  2. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3 65
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4 65
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 65
  5. Tesmin transcription is regulated differently during male and female meiosis. (PMID: 14648882) Olesen C. … Byskov A.G. (Mol. Reprod. Dev. 2004) 3 65

Products for TESMIN Gene

Sources for TESMIN Gene

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