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Aliases for TESMIN Gene

Aliases for TESMIN Gene

  • Testis Expressed Metallothionein Like Protein 2 3 5
  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • MTL5 3 4
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • Tesmin 3
  • MTLT 3

External Ids for TESMIN Gene

Previous HGNC Symbols for TESMIN Gene

  • MTL5

Summaries for TESMIN Gene

Entrez Gene Summary for TESMIN Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TESMIN Gene

TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot for TESMIN Gene

  • May have a role in spermatogenesis.

Additional gene information for TESMIN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESMIN Gene

Genomics for TESMIN Gene

GeneHancer (GH) Regulatory Elements for TESMIN Gene

Promoters and enhancers for TESMIN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I068748 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.8 +1.0 1013 3.2 PKNOX1 SIN3A ETS1 GLIS2 CBX5 SP3 ZNF592 MBD2 CTCF KLF1 TESMIN GAL
GH11I068854 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -104.9 -104945 4.5 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 ZHX2 MXD4 REST IGHMBP2 LOC105369364 TESMIN MRPL21 CPT1A
GH11I068869 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 11.1 -118.7 -118713 1 HDAC1 BCOR CTCF TAL1 CDC5L RAD21 TEAD3 TCF12 GATA3 MTA3 LOC105369364 IGHMBP2 MRPL21 TESMIN MRGPRF MRGPRF-AS1 CPT1A
GH11I068658 Enhancer 0.9 ENCODE 16.9 +92.3 92325 1.4 NFIB ZSCAN4 INSM2 FEZF1 ZNF2 ZBTB40 RFX5 ZNF335 ZNF121 GLIS2 TESMIN GAL PPP6R3 ENSG00000260808
GH11I068816 Enhancer 0.9 ENCODE dbSUPER 11.2 -65.7 -65745 0.8 ESRRA ZSCAN4 CDC5L BCL11B TCF12 ZFHX2 CTBP1 POLR2A EGR1 NR2F6 IGHMBP2 MRPL21 TESMIN LOC105369364 GC11P068804 CPT1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TESMIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for TESMIN Gene

Genomic Locations for TESMIN Gene
44,891 bases
Minus strand

Genomic View for TESMIN Gene

Genes around TESMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESMIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESMIN Gene

Proteins for TESMIN Gene

  • Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for TESMIN Gene

    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for TESMIN Gene


neXtProt entry for TESMIN Gene

Post-translational modifications for TESMIN Gene

No Post-translational modifications

Other Protein References for TESMIN Gene

No data available for DME Specific Peptides for TESMIN Gene

Domains & Families for TESMIN Gene

Gene Families for TESMIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TESMIN Gene

Suggested Antigen Peptide Sequences for TESMIN Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the lin-54 family.
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with TESMIN: view

Function for TESMIN Gene

Molecular function for TESMIN Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view
genes like me logo Genes that share phenotypes with TESMIN: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene

Localization for TESMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene

Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESMIN gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TESMIN: view

Pathways & Interactions for TESMIN Gene

SuperPathways for TESMIN Gene

No Data Available

Interacting Proteins for TESMIN Gene

Gene Ontology (GO) - Biological Process for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene

Drugs & Compounds for TESMIN Gene

(1) Drugs for TESMIN Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 202
genes like me logo Genes that share compounds with TESMIN: view

Transcripts for TESMIN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESMIN Gene

No ASD Table

Relevant External Links for TESMIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TESMIN Gene

NURSA nuclear receptor signaling pathways regulating expression of TESMIN Gene:


mRNA Expression by UniProt/SwissProt for TESMIN Gene:

Tissue specificity: Expressed specifically in testis.

Evidence on tissue expression from TISSUES for TESMIN Gene

  • Nervous system(4.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESMIN Gene

Orthologs for TESMIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TESMIN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTL5 33 34
  • 99.21 (n)
(Bos Taurus)
Mammalia MTL5 33
  • 84.48 (n)
(Canis familiaris)
Mammalia MTL5 33 34
  • 83.66 (n)
(Mus musculus)
Mammalia Mtl5 33 34
  • 73.35 (n)
Tesmin 16
(Rattus norvegicus)
Mammalia Mtl5 33
  • 72.86 (n)
(Ornithorhynchus anatinus)
Mammalia MTL5 34
  • 69 (a)
(Monodelphis domestica)
Mammalia MTL5 34
  • 47 (a)
(Gallus gallus)
Aves MTL5 33 34
  • 65.4 (n)
(Anolis carolinensis)
Reptilia MTL5 34
  • 61 (a)
(Danio rerio)
Actinopterygii MTL5 34
  • 24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 33
fruit fly
(Drosophila melanogaster)
Insecta mip120 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea lin-54 34
  • 23 (a)
Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TESMIN Gene

Gene Tree for TESMIN (if available)
Gene Tree for TESMIN (if available)

Paralogs for TESMIN Gene

Paralogs for TESMIN Gene

genes like me logo Genes that share paralogs with TESMIN: view

Variants for TESMIN Gene

Sequence variations from dbSNP and Humsavar for TESMIN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000026241 -- 68,708,204(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000035724 -- 68,745,480(-) G/A intron_variant
rs1000040954 -- 68,712,052(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000100605 -- 68,737,150(-) C/T 3_prime_UTR_variant, intron_variant
rs1000160741 -- 68,742,889(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TESMIN Gene

Variant ID Type Subtype PubMed ID
dgv670n106 CNV deletion 24896259
esv2744665 CNV deletion 23290073
esv2744666 CNV deletion 23290073
nsv1070468 CNV deletion 25765185
nsv509422 CNV insertion 20534489

Variation tolerance for TESMIN Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESMIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene

Disorders for TESMIN Gene

No disorders were found for TESMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene

Publications for TESMIN Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T … Mitsui Y (Genomics 1999) 3 4 22 58
  2. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A … Wigdahl B (Journal of neurovirology 2013) 3 58
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 4 58
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
  5. Tesmin transcription is regulated differently during male and female meiosis. (PMID: 14648882) Olesen C … Byskov AG (Molecular reproduction and development 2004) 3 58

Products for TESMIN Gene

Sources for TESMIN Gene

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