Aliases for TESMIN Gene
Aliases for TESMIN Gene
External Ids for TESMIN Gene
- HGNC: 7446
- Entrez Gene: 9633
- Ensembl: ENSG00000132749
- OMIM: 604374
- UniProtKB: Q9Y4I5
Previous HGNC Symbols for TESMIN Gene
- MTL5
Summaries for TESMIN Gene
-
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TESMIN Gene
TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.
UniProtKB/Swiss-Prot for TESMIN Gene
-
May have a role in spermatogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESMIN Gene
Genomics for TESMIN Gene
Regulatory Elements for TESMIN Gene
Enhancers for TESMIN Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G068854 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 12.3 | -104.9 | -104945 | 4.5 | FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 ZHX2 MXD4 ZNF592 | IGHMBP2 LOC105369364 TESMIN MRPL21 CPT1A |
| GH11G068693 | 0.8 | ENCODE | 22.8 | +56.9 | 56902 | 1.5 | HDGF BRD4 ESRRA MXI1 SAP130 TAF1 ARID4B SIN3A ZNF335 GATA3 | TESMIN GAL MRPL21 IGHMBP2 |
| GH11G068658 | 0.9 | ENCODE | 16.9 | +92.3 | 92325 | 1.4 | NFIB ZSCAN4 INSM2 SIN3A FEZF1 ZBTB40 ZNF2 RAD21 ZNF121 GLIS2 | TESMIN GAL PPP6R3 ENSG00000260808 |
| GH11G068748 | 1 | ENCODE | 14.7 | +1.0 | 1013 | 3.2 | PKNOX1 SIN3A ETS1 GLIS2 CBX5 GATA2 FOS KDM4B SP3 ZNF592 | TESMIN GAL |
| GH11G068689 | 0.7 | ENCODE | 21 | +61.4 | 61437 | 1.0 | ZNF263 BCOR SMARCA5 PTBP1 ZMYM3 NFXL1 TEAD3 ETV4 ADNP GABPB1 | TESMIN GAL |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TESMIN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TESMIN Gene
- Chromosome:
- 11
- Start:
- 68,706,674 bp from pter
- End:
- 68,751,564 bp from pter
- Size:
- 44,891 bases
- Orientation:
- Minus strand
Genomic View for TESMIN Gene
Genes around TESMIN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.3 by Ensembl
- 11q13.3 by Entrez Gene
- 11q13.3 by HGNC
TESMIN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TESMIN Gene
Proteins for TESMIN Gene
-
Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4I5-MTL5_HUMAN
- Recommended name:
- Tesmin
- Protein Accession:
- Q9Y4I5
- A8K8J3
- Q4G182
- Q6P2E2
- Q8NCC8
Protein attributes for TESMIN Gene
- Size:
- 508 amino acids
- Molecular mass:
- 55025 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Post-translational modifications for TESMIN Gene
Other Protein References for TESMIN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TESMIN
- Novus Biologicals Antibodies for TESMIN
- Invitrogen Antibodies for TESMIN
- antibodies-online Antibodies for TESMIN: See all 27
- GeneTex MTL5 antibody for TESMIN
Protein Products
-
OriGene Purified Proteins for TESMIN
- Search Origene for MassSpec and Protein Over-expression Lysates for TESMIN
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- Novus Biologicals proteins for TESMIN
- antibodies-online Proteins for TESMIN: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TESMIN
-
Abcam proteins for TESMIN
Assay Products
- antibodies-online Kits for TESMIN: See all 3
No data available for DME Specific Peptides for TESMIN Gene
Domains & Families for TESMIN Gene
Protein Domains for TESMIN Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TESMIN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y4I5- Family:
-
- Belongs to the lin-54 family.
No data available for Gene Families for TESMIN Gene
Function for TESMIN Gene
Molecular function for TESMIN Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in spermatogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | NAS | 10191092 |
Phenotypes for TESMIN Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TESMIN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TESMIN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
- Search ViGene Biosciences for TESMIN
CRISPR Products
-
OriGene CRISPR knockouts for TESMIN
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miRNA for TESMIN Gene
- miRTarBase miRNAs that target TESMIN
-
- hsa-mir-378a-5p (MIRT043976)
- hsa-mir-6513-5p (MIRT630012)
- hsa-mir-887-5p (MIRT630013)
- hsa-mir-3913-5p (MIRT630014)
- hsa-mir-3122 (MIRT630015)
- hsa-mir-450a-1-3p (MIRT630016)
- hsa-mir-6780a-5p (MIRT630017)
- hsa-mir-6779-5p (MIRT630018)
- hsa-mir-3689c (MIRT630019)
- hsa-mir-3689b-3p (MIRT630020)
- hsa-mir-3689a-3p (MIRT630021)
- hsa-mir-30b-3p (MIRT630022)
- hsa-mir-1273h-5p (MIRT630023)
- hsa-mir-6788-5p (MIRT630024)
- hsa-mir-30c-2-3p (MIRT630025)
- hsa-mir-30c-1-3p (MIRT630026)
- hsa-mir-7977 (MIRT630027)
- hsa-mir-6799-5p (MIRT630028)
- hsa-mir-6883-5p (MIRT630029)
- hsa-mir-6785-5p (MIRT630030)
- hsa-mir-4728-5p (MIRT630031)
- hsa-mir-149-3p (MIRT630032)
- hsa-mir-7106-5p (MIRT630033)
- hsa-mir-24-3p (MIRT630034)
- hsa-mir-4284 (MIRT630035)
- hsa-mir-9-5p (MIRT630036)
- hsa-mir-4267 (MIRT630037)
- hsa-mir-629-3p (MIRT650077)
- hsa-mir-6780b-5p (MIRT650078)
- hsa-mir-4725-3p (MIRT650079)
- hsa-mir-4271 (MIRT650080)
- hsa-mir-627-3p (MIRT650081)
- hsa-mir-134-3p (MIRT650082)
- hsa-mir-7114-5p (MIRT650083)
- hsa-mir-622 (MIRT650084)
miRNA Products
- Search ViGene Biosciences for TESMIN
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TESMIN
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-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TESMIN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TESMIN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TESMIN
-
ViGene Biosciences adenoviral particle packaged cDNA for TESMIN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TESMIN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene
Localization for TESMIN Gene
Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene
- Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for TESMIN Gene
No Data Available
Interacting Proteins for TESMIN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006875 | cellular metal ion homeostasis | NAS | 10191092 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | NAS | 10191092 |
| GO:0010038 | response to metal ion | NAS | 10191092 |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene
Transcripts for TESMIN Gene
mRNA/cDNA for TESMIN Gene
- (5) REFSEQ mRNAs :
- (80) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TESMIN
- GenScript: Design CRISPR guide RNA sequences for TESMIN
miRNA Products
- Search ViGene Biosciences for TESMIN
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TESMIN
- Browse OriGene Inhibitory RNA Products For TESMIN
-
ViGene Biosciences ready-to-package AAV shRNAs for TESMIN gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TESMIN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TESMIN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for TESMIN Gene
NURSA nuclear receptor signaling pathways regulating expression of TESMIN Gene:
TESMINmRNA Expression by UniProt/SwissProt for TESMIN Gene:
Q9Y4I5-MTL5_HUMAN
Tissue specificity:
Expressed specifically in testis.
Evidence on tissue expression from TISSUES for TESMIN Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for TESMIN
-
OriGene qPCR primer pairs and template standards for TESMIN
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESMIN Gene
Orthologs for TESMIN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTL5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MTL5 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MTL5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtl5 34 35 |
|
||
| Tesmin 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Mtl5 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTL5 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MTL5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTL5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTL5 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | MTL5 35 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5658 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mip120 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | lin-54 35 |
|
OneToMany |
- Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TESMIN Gene
Variants for TESMIN Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026241 | -- | 68,708,204(+) | GGGAG(C/G)CTGGT | intron-variant, utr-variant-3-prime | |
| rs1000035724 | -- | 68,745,480(+) | GAGCA(A/G)AAGAG | intron-variant | |
| rs1000040954 | -- | 68,712,052(+) | CATCT(C/G)CACCT | intron-variant | |
| rs1000100605 | -- | 68,737,150(+) | GAAGT(C/T)ATTTT | intron-variant, utr-variant-3-prime | |
| rs1000160741 | -- | 68,742,889(+) | TTTGC(C/T)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv670n106 | CNV | deletion | 24896259 |
| esv2744665 | CNV | deletion | 23290073 |
| esv2744666 | CNV | deletion | 23290073 |
| nsv1070468 | CNV | deletion | 25765185 |
| nsv509422 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.45;
64.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TESMIN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TESMIN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene
Disorders for TESMIN Gene
Relevant External Links for TESMIN
No disorders were found for TESMIN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene
Publications for TESMIN Gene
- A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T. … Mitsui Y. (Genomics 1999) 3 4 22 64
- Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3 64
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4 64
- Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64
- Tesmin transcription is regulated differently during male and female meiosis. (PMID: 14648882) Olesen C. … Byskov A.G. (Mol. Reprod. Dev. 2004) 3 64
Products for TESMIN Gene
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- Custom Antibody ServicesOriGene Antibodies for TESMIN
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- antibodies-online Antibodies for TESMIN: See all 27
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TESMIN
- VectorBuilder custom plasmid, inducible vectors for TESMIN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TESMIN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TESMIN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (96) MaxQB
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- (98) BioGPS
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- (100) COMPARTMENTS
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