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Aliases for TESK2 Gene

Aliases for TESK2 Gene

  • Testis-Specific Kinase 2 2 3 5
  • Testicular Protein Kinase 2 4
  • EC 2.7.12.1 4

External Ids for TESK2 Gene

Previous GeneCards Identifiers for TESK2 Gene

  • GC01M045536
  • GC01M044809
  • GC01M045239
  • GC01M045222
  • GC01M045478
  • GC01M045582
  • GC01M045809
  • GC01M043921

Summaries for TESK2 Gene

Entrez Gene Summary for TESK2 Gene

  • This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for TESK2 Gene

TESK2 (Testis-Specific Kinase 2) is a Protein Coding gene. Among its related pathways are Focal Adhesion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK1.

UniProtKB/Swiss-Prot for TESK2 Gene

  • Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at Ser-3. May play an important role in spermatogenesis.

Gene Wiki entry for TESK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESK2 Gene

Genomics for TESK2 Gene

Regulatory Elements for TESK2 Gene

Enhancers for TESK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F045408 1.5 FANTOM5 Ensembl ENCODE 13 +80.3 80342 5.2 FEZF1 ZNF2 ZNF121 GATA2 KLF7 FOS TSHZ1 MEF2D ZSCAN16 SMARCA4 PRDX1 TMA16P2 ENSG00000250719 RPS8 TESK2 RPL7AP16 RPS15AP10 HMGB1P48 MMACHC CCDC163
GH01F045334 1.4 Ensembl ENCODE 11.3 +153.1 153069 7.9 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 PRDX1 MMACHC CCDC163 TESK2 MUTYH BTBD19 RPS8 UROD TOE1 HPDL
GH01F045443 1.1 FANTOM5 ENCODE 11.5 +47.3 47336 1.5 ESRRA HINFP DDX20 PTRF PYGO2 ZBTB40 ZNF644 RELA GATA3 ZNF639 CCDC163 PRDX1 KIF2C TESK2 ZSWIM5 TOE1 ENSG00000236872
GH01F045444 1.1 Ensembl ENCODE 11.5 +46.3 46342 0.4 PKNOX1 PTRF RCOR1 CEBPB HDAC8 ZNF217 CREB3 MEF2D TFDP1 PBX2 CCDC163 KIF2C TESK2 ZSWIM5 TOE1 ENSG00000236872
GH01F045429 0.7 FANTOM5 17 +61.6 61638 0.1 SMARCE1 HDAC1 RNF2 TBL1XR1 DPF2 ARID1B POLR2H GATA2 SMARCA4 IKZF1 TESK2 ENSG00000236872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TESK2 on UCSC Golden Path with GeneCards custom track

Promoters for TESK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000535869 442 2201 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TESK2 Gene

Chromosome:
1
Start:
45,343,883 bp from pter
End:
45,491,342 bp from pter
Size:
147,460 bases
Orientation:
Minus strand

Genomic View for TESK2 Gene

Genes around TESK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESK2 Gene

Proteins for TESK2 Gene

  • Protein details for TESK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S53-TESK2_HUMAN
    Recommended name:
    Dual specificity testis-specific protein kinase 2
    Protein Accession:
    Q96S53
    Secondary Accessions:
    • Q5T422
    • Q5T423
    • Q8N520
    • Q9Y3Q6

    Protein attributes for TESK2 Gene

    Size:
    571 amino acids
    Molecular mass:
    63639 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TESK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESK2 Gene

Post-translational modifications for TESK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TESK2
  • Santa Cruz Biotechnology (SCBT) Antibodies for TESK2

No data available for DME Specific Peptides for TESK2 Gene

Domains & Families for TESK2 Gene

Gene Families for TESK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S53

UniProtKB/Swiss-Prot:

TESK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TESK2: view

Function for TESK2 Gene

Molecular function for TESK2 Gene

GENATLAS Biochemistry:
testis specific protein kinase 2,expressed in testis and prostate,involved in spermatogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on Ser-219.
UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at Ser-3. May play an important role in spermatogenesis.

Enzyme Numbers (IUBMB) for TESK2 Gene

Gene Ontology (GO) - Molecular Function for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10512679
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with TESK2: view
genes like me logo Genes that share phenotypes with TESK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TESK2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESK2 Gene

Localization for TESK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESK2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with TESK2: view

Pathways & Interactions for TESK2 Gene

SuperPathways for TESK2 Gene

SuperPathway Contained pathways
1 Focal Adhesion
genes like me logo Genes that share pathways with TESK2: view

Pathways by source for TESK2 Gene

1 BioSystems pathway for TESK2 Gene

SIGNOR curated interactions for TESK2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007283 spermatogenesis ISS,TAS --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IEA,ISS --
genes like me logo Genes that share ontologies with TESK2: view

Drugs & Compounds for TESK2 Gene

(2) Drugs for TESK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Magnesium Nutra 0
genes like me logo Genes that share compounds with TESK2: view

Transcripts for TESK2 Gene

Unigene Clusters for TESK2 Gene

Testis-specific kinase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -
SP3:

Relevant External Links for TESK2 Gene

GeneLoc Exon Structure for
TESK2
ECgene alternative splicing isoforms for
TESK2

Expression for TESK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TESK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TESK2 Gene

This gene is overexpressed in Blymphocyte (31.0), Testis (18.2), and Prostate (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TESK2 Gene



Protein tissue co-expression partners for TESK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TESK2 Gene:

TESK2

SOURCE GeneReport for Unigene cluster for TESK2 Gene:

Hs.591499

mRNA Expression by UniProt/SwissProt for TESK2 Gene:

Q96S53-TESK2_HUMAN
Tissue specificity: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.
genes like me logo Genes that share expression patterns with TESK2: view

Primer Products

No data available for mRNA differential expression in normal tissues for TESK2 Gene

Orthologs for TESK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TESK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TESK2 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia TESK2 34 35
  • 90.83 (n)
dog
(Canis familiaris)
Mammalia TESK2 34 35
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Tesk2 34 16 35
  • 86.43 (n)
rat
(Rattus norvegicus)
Mammalia Tesk2 34
  • 86.2 (n)
oppossum
(Monodelphis domestica)
Mammalia TESK2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TESK2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TESK2 35
  • 76 (a)
OneToOne
LOC100858275 34
  • 71.85 (n)
lizard
(Anolis carolinensis)
Reptilia TESK2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tesk2 34
  • 69.59 (n)
zebrafish
(Danio rerio)
Actinopterygii tesk2 34 35
  • 66.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta cdi 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T25B9.5 35
  • 18 (a)
ManyToMany
Y52D5A.2 35
  • 18 (a)
ManyToMany
Y69E1A.3 35
  • 17 (a)
ManyToMany
K09B11.5 35
  • 16 (a)
ManyToMany
kin-21 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for TESK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TESK2 Gene

ENSEMBL:
Gene Tree for TESK2 (if available)
TreeFam:
Gene Tree for TESK2 (if available)

Paralogs for TESK2 Gene

Paralogs for TESK2 Gene

(13) SIMAP similar genes for TESK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TESK2: view

Variants for TESK2 Gene

Sequence variations from dbSNP and Humsavar for TESK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_041214 A breast infiltrating ductal carcinoma sample
rs1006215 -- 45,444,273(+) AAAAC(A/T)TTGGT intron-variant
rs1006216 -- 45,444,322(+) ATTAT(A/G)TGCAA intron-variant
rs1007858 -- 45,446,333(-) CAGAT(A/G)TGCAA intron-variant
rs1007859 -- 45,446,234(-) GATCC(A/G)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TESK2 Gene

Variant ID Type Subtype PubMed ID
nsv945919 CNV duplication 23825009
nsv829726 CNV loss 17160897
nsv1145341 CNV deletion 24896259
nsv1126996 CNV deletion 24896259
esv3893512 CNV gain 25118596
esv3585907 CNV loss 21293372
esv3585906 CNV loss 21293372
esv3585905 CNV loss 21293372
esv2750837 CNV loss 17911159
esv2747796 CNV deletion 23290073
esv2669051 CNV deletion 23128226
esv2663522 CNV deletion 23128226

Variation tolerance for TESK2 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TESK2 Gene

Human Gene Mutation Database (HGMD)
TESK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESK2 Gene

Disorders for TESK2 Gene

Relevant External Links for TESK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TESK2

No disorders were found for TESK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESK2 Gene

Publications for TESK2 Gene

  1. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PMID: 10512679) Rosok O. … Aasheim H.-C. (Genomics 1999) 2 3 4 22 64
  2. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PMID: 11418599) Toshima J. … Mizuno K. (J. Biol. Chem. 2001) 3 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. (PMID: 26631746) Zhang C. … Kaelin W.G. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64

Products for TESK2 Gene

Sources for TESK2 Gene

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