TESK2 Gene
protein-coding GIFtS: 57
GCID: GC01M045809
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|
testis-specific kinase 2
| |
Aliases
for TESK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis-Specific Kinase 21 2 | | Testicular Protein Kinase 22 3 | | Dual Specificity Testis-Specific Protein Kinase 22 | | EC 2.7.12.13 |
Export aliases for TESK2 gene to outside databasesPrevious GC identifers: GC01M045536 GC01M044809 GC01M045239 GC01M045222 GC01M045478 GC01M045582 GC01M043921 |
Summaries
for TESK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TESK2:
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that isstructurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing proteinkinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroupof the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. Thedevelopmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stagesand/or early stages of spermiogenesis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenoussubstrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an importantrole in spermatogenesis
Gene Wiki entry for TESK2
|
Genomic Views
for TESK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TESK2 gene promoter:
SRF C/EBPbeta SRF (504 AA) E47 MZF-1 ARP-1 ZID Msx-1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TESK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TESK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p32TESK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M045809: view genomic region
(about GC identifiers)
Start:
|
45,809,555 bp from pter |
End:
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45,956,872 bp from pter |
Size:
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147,318 bases |
Orientation:
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minus strand |
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Proteins
for TESK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53 (See
protein sequence)Recommended Name: Dual specificity testis-specific protein kinase 2 Size: 571 amino acids; 63639 Da
Cofactor: Magnesium (By similarity)
Cofactor: Manganese (By similarity)
Subcellular location: Nucleus
Secondary accessions: Q5T422 Q5T423 Q8N520 Q9Y3Q6Alternative splicing: 3 isoforms: Q96S53-1 Q96S53-2 Q96S53-3 Explore the universe of human proteins at neXtProt for TESK2: NX_Q96S53
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96S53
TESK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009101.2
ENSEMBL proteins: ENSP00000361156 ENSP00000361158 ENSP00000343940 ENSP00000441746 ENSP00000397244
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TESK2 for ontologies About GeneDecksing
TESK2 Antibody Products:
Assay Products for TESK2: |
Protein
Domains /
Families
for TESK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TESK2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96S53ProtoNet protein and cluster: Q96S53 1 Blocks protein family: IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TESK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenoussubstrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an importantrole in spermatogenesisCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by autophosphorylation on Ser-219 (By similarity) Genatlas biochemistry entry for TESK2:testis specific protein kinase 2,expressed in testis and prostate,involved in spermatogenesis
Enzyme Number (IUBMB): EC 2.7.12.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TESK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TESK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TESK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TESK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESK2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TESK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TESK2:
|
Pathways & Interactions
for TESK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Focal Adhesion | |
1  BioSystems Pathway for TESK2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TESK2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TESK2 (Q96S531, 3 ENSP000003611584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TESK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TESK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TESK2
4 HMDB Compounds for TESK2 About this table
Search CenterWatch for drugs/clinical trials and news about TESK2
|
Transcripts
for TESK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TESK2 gene: NM_007170.2 Unigene Cluster for TESK2: Testis-specific kinase 2 Hs.591499 [show with all ESTs]Unigene Representative Sequence: NM_0071707 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372084 ENST00000372086(uc001cns.1 uc010olo.1 uc009vxs.1)
ENST00000486676 ENST00000493974 ENST00000341771(uc009vxr.1) ENST00000538496
ENST00000451835(uc010olp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TESK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TESK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TESK2 (NM_007170) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TESK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TESK2 |
Additional cDNA sequence: AB057597.1 AJ132545.1 AK027573.1 AK294172.1 AK299269.1 AK302494.1 BC022194.1 BC033085.1 BX648441.1 12 DOTS entries: DT.100708959 DT.97854702 DT.100030291 DT.95088446 DT.412280 DT.99937199 DT.121426000 DT.416232 DT.92443347 DT.91904553 DT.95291328 DT.95293152 24/62 AceView cDNA sequences (see all 62): BE465520 BX101631 BC033085 BU161792 BU623967 BM562070 BM543888 AL705850 AI693741 BM971440 BM710379 AL042238 AK027573 AI889368 AI681902 BG719507 AI687656 AI659068 CD367940 AI026904 BI193421 BX648441 AI693120 BM671798
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TESK2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TESK2
|
Expression
for TESK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TESK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGAGCTT
About this image
See TESK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TESK2
SOURCE GeneReport for Unigene cluster: Hs.591499
UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53Tissue specificity: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells
SABiosciences Custom PCR Arrays for TESK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TESK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TESK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TESK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TESK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESK2 |
Orthologs
for TESK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TESK2 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for TESK2 (if available)
TreeFam Gene Tree for TESK2 (if available) |
Paralogs
for TESK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TESK2 gene
- LIMK22 TESK12 LIMK12
13 SIMAP similar genes for TESK2 using alignment to 4 protein entries: TESK2_HUMAN (see all proteins):BRAF TNNI3K TESK1 LIMK2 NEK9 RPS6KA2
ULK1 FGFR1 RPS6KA1 BRSK2 STK25 FES
TYK2
TESK2 for paralogs About GeneDecksing
|
Genomic Variants
for TESK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TESK2 (45809555 - 45956872 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TESK2
1 CNV: 8915 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TESK2 |
|
Disorders
/ Diseases
for TESK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TESK2 for disorders About GeneDecksing
OMIM gene information: 604746
OMIM disorders: --
2  diseases for TESK2: About MalaCardsprostatitis myotonic dystrophy
1 disease from the University of Copenhagen DISEASES database for TESK2:Alcohol dependence Export disorders for TESK2 gene to outside databases
|
Publications
for TESK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TESK2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TESK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PubMed id 10512679)1, 2, 3, 9 Rosok O.... Aasheim H.-C. (1999)
- Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PubMed id 11418599)1, 2, 9 Toshima J.... Mizuno K. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PubMed id 11340065)1 Sumi T....Nakamura T. (2001)
|
External Searches for TESK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TESK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TESK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TESK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TESK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TESK2 gene:
Search GeneIP for patents involving TESK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TESK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TESK2 | | OriGene Custom Protein Services for TESK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TESK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TESK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TESK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TESK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TESK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TESK2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESK2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TESK2 |
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