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TESK2 Gene

protein-coding   GIFtS: 59
GCID: GC01M045809

Testis-Specific Kinase 2

  Search for TESK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis-Specific Kinase 21 2
Testicular Protein Kinase 22 3
Dual Specificity Testis-Specific Protein Kinase 22
EC 2.7.12.13

External Ids:    HGNC: 117321   Entrez Gene: 104202   Ensembl: ENSG000000707597   OMIM: 6047465   UniProtKB: Q96S533   

Export aliases for TESK2 gene to outside databases

Previous GC identifers: GC01M045536 GC01M044809 GC01M045239 GC01M045222 GC01M045478 GC01M045582 GC01M043921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TESK2 Gene:
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is
structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing
protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the
TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and
prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene
in meitoic stages and/or early stages of spermiogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TESK2 Gene:
TESK2 (testis-specific kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is LIMK2.

UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53
Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an
important role in spermatogenesis

Gene Wiki entry for TESK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TESK2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   E47   MZF-1   ARP-1   ZID   Msx-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTESK2 promoter sequence
   Search Chromatin IP Primers for TESK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TESK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p32

TESK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TESK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045809:  view genomic region     (about GC identifiers)

Start:
45,809,555 bp from pter      End:
45,956,872 bp from pter
Size:
147,318 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53 (See protein sequence)
Recommended Name: Dual specificity testis-specific protein kinase 2  
Size: 571 amino acids; 63639 Da
Cofactor: Magnesium (By similarity)
Cofactor: Manganese (By similarity)
Secondary accessions: Q5T422 Q5T423 Q8N520 Q9Y3Q6
Alternative splicing: 3 isoforms:  Q96S53-1   Q96S53-2   Q96S53-3   

Explore the universe of human proteins at neXtProt for TESK2: NX_Q96S53

Explore proteomics data for TESK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TESK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009101.2  
    ENSEMBL proteins: 
     ENSP00000361156   ENSP00000361158   ENSP00000343940   ENSP00000441746   ENSP00000397244  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific kinase 2
    TESK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q96S53

    ProtoNet protein and cluster: Q96S53

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TESK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TESK2_HUMAN, Q96S53
    Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
    substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an
    important role in spermatogenesis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation on Ser-219 (By similarity)

         Genatlas biochemistry entry for TESK2:
    testis specific protein kinase 2,expressed in testis and prostate,involved in spermatogenesis

         Enzyme Number (IUBMB): EC 2.7.12.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10512679
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TESK2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TESK2:
     Decreased Salmonella enterica   Elongated cells with protrusio  Increased cell death HMECs cel  Increased colony dispersion (i 

    Animal Models:
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    miRTarBase miRNAs that target TESK2:
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    Block miRNA regulation of human, mouse, rat TESK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TESK2 (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-328 hsa-miR-301a hsa-miR-519a hsa-miR-3167 hsa-miR-9 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTESK2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TESK2_HUMAN, Q96S53: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TESK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TESK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    2Regulation of Microtubule Cytoskeleton
    Regulation of Microtubule Cytoskeleton


    2 BioSystems Pathways for TESK2
        Focal Adhesion
    Regulation of Microtubule Cytoskeleton


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TESK2
    Interactions:

        GeneGlobe Interaction Network for TESK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TESK2 (Q96S531, 3 ENSP000003611584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    DSTNP609813, ENSP000002460694I2D: score=2 STRING: ENSP00000246069
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    HSP90AB1P082381EBI-1384110,EBI-352572
    PARVAENSP000003340084STRING: ENSP00000334008
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007283spermatogenesis ISS--
    GO:0030036actin cytoskeleton organization ISS--
    GO:0048041focal adhesion assembly ISS--

    Find genes that share ontologies with TESK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TESK2

    4 HMDB Compounds for TESK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TESK2 gene: 
    NM_007170.2  

    Unigene Cluster for TESK2:

    Testis-specific kinase 2
    Hs.591499  [show with all ESTs]
    Unigene Representative Sequence: NM_007170
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372084 ENST00000372086(uc001cns.1 uc010olo.1 uc009vxs.1)
    ENST00000486676 ENST00000493974 ENST00000341771(uc009vxr.1) ENST00000538496
    ENST00000451835(uc010olp.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat TESK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TESK2 (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-328 hsa-miR-301a hsa-miR-519a hsa-miR-3167 hsa-miR-9 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTESK2 3' UTR sequence
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    Additional mRNA sequence: 

    AB057597.1 AJ132545.1 AK027573.1 AK294172.1 AK299269.1 AK302494.1 BC022194.1 BC033085.1 
    BX648441.1 

    12 DOTS entries:

    DT.100708959  DT.97854702  DT.100030291  DT.95088446  DT.412280  DT.99937199  DT.121426000  DT.416232 
    DT.92443347  DT.91904553  DT.95291328  DT.95293152 

    Selected AceView cDNA sequences (see all 62):

    BE465520 BU623967 BU161792 BX101631 BC033085 BF817437 CD300162 AL705850 
    AK027573 AI687656 AI026904 BM710379 BE217779 CO248966 BX648441 AB057597 
    AL042238 CB854542 BX385449 AI078601 AJ132545 CD367940 BX432983 AI693741 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TESK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:              -     -                                       
    SP2:              -                                             
    SP3:                                                            


    ECgene alternative splicing isoforms for TESK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TESK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGCTT
    TESK2 Expression
    About this image


    TESK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
    TESK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TESK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591499

    UniProtKB/Swiss-Prot: TESK2_HUMAN, Q96S53
    Tissue specificity: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli
    cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TESK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tesk21 , 5 testis-specific kinase 21, 5 86.43(n)1
    87.89(a)1
      4 (53.30 cM)5
    2306611  NM_146151.41  NP_666263.31 
     1167209485 
    chicken
    (Gallus gallus)
    Aves LOC1008582751 dual specificity testis-specific protein kinase 2-like 71.85(n)
    79.65(a)
      100858275  XM_003641688.2  XP_003641736.2 
    lizard
    (Anolis carolinensis)
    Reptilia TESK26
    testis-specific kinase 2
    67(a)
    1 ↔ 1
    4(110261035-110317315)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX761654.12   -- 70.68(n)    BX761654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tesk21 testis-specific kinase 2 66.86(n)
    71.93(a)
      568213  NM_001110476.1  NP_001103946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdi6
    center divider
    21(a)
    1 → many
    3R(14870604-14920076)
    worm
    (Caenorhabditis elegans)
    Secernentea Y52D5A.26
    T25B9.56
    (see all 5)
    Protein T25B9.5 (T25B9.5) mRNA, complete cds
    (see all 5)
    18(a)
    18(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    IV(5462501-5464275) WBGene00021793
    IV(10752430-10754589) WBGene00012011


    ENSEMBL Gene Tree for TESK2 (if available)
    TreeFam Gene Tree for TESK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TESK2 gene
    LIMK22  TESK12  LIMK12  
    13 SIMAP similar genes for TESK2 using alignment to 4 protein entries:     TESK2_HUMAN (see all proteins):
    BRAF    TNNI3K    TESK1    LIMK2    NEK9    RPS6KA2
    ULK1    FGFR1    RPS6KA1    BRSK2    STK25    FES
    TYK2

    Find genes that share paralogs with TESK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TESK2 (see all 2667)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412144
    A breast infiltrating ductal carcinoma sample4--see VAR_0412142 G A mis40--------
    rs1430410191,2
    --45810181(+) AGAACC/TGGGGT 1 -- ut310--------
    rs787986651,2
    C,F--45810230(+) TCTGGT/ACCTAT 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1816426221,2
    --45810239(+) ATCTGA/GGGAAG 1 -- ut310--------
    rs1870525821,2
    C--45810516(+) CTCACA/CCATCC 2 G V mis10--------
    rs2016863491,2
    C--45810531(+) TTCCCT/CGGGTT 2 /Q /R mis11Minor allele frequency- C:0.00EU 1323
    rs1506963311,2
    C--45810542(+) TGCAGG/TCCTAT 2 G syn10--------
    rs560306941,2
    C--45810560(+) GTGGAC/GAAGGT 2 F L mis10--------
    rs2006760181,2
    --45810620(+) GCACCC/TGCAGG 2 A syn10--------
    rs2020383471,2
    C--45810646(+) CTGGGG/ACCTGG 2 /P /S mis11Minor allele frequency- A:0.00EU 1319

    HapMap Linkage Disequilibrium report for TESK2 (45809555 - 45956872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TESK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747796CNV Deletion23290073
    esv2669051CNV Deletion23128226
    esv2663522CNV Deletion23128226
    nsv829726CNV Loss17160897
    esv2750837CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TESK2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604746    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TESK2:
    Alcohol dependence

    Find genes that share disorders with TESK2           About GenesLikeMe


    Export disorders for TESK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TESK2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TESK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PubMed id 10512679)1, 2, 3, 9 Rosok O.... Aasheim H.-C. (Genomics 1999)
    2. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PubMed id 11418599)1, 2, 9 Toshima J.... Mizuno K. (J. Biol. Chem. 2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10420 HGNC: 11732 AceView: TESK2 Ensembl:ENSG00000070759 euGenes: HUgn10420
    ECgene: TESK2 H-InvDB: TESK2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TESK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TESK2 gene:
    Search GeneIP for patents involving TESK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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