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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TESK1 Gene

protein-coding   GIFtS: 60
GCID: GC09P035605

Testis-Specific Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis-Specific Kinase 11 2
Testicular Protein Kinase 12 3
Testis Specific Kinase-11
Testis-Specific Kinase-11
Dual Specificity Testis-Specific Protein Kinase 12
EC 2.7.12.13

External Ids:    HGNC: 117311   Entrez Gene: 70162   Ensembl: ENSG000001071407   OMIM: 6017825   UniProtKB: Q155693   

Export aliases for TESK1 gene to outside databases

Previous GC identifers: GC09P035917 GC09P035774 GC09P035595 GC09P035561


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TESK1 Gene:
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a
C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM
motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone
in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene
suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TESK1 Gene: 
TESK1 (testis-specific kinase 1) is a protein-coding gene. Diseases associated with TESK1 include myotonic dystrophy, and teratocarcinoma, and among its related super-pathways are Cell-cell junction organization and Cell-extracellular matrix interactions. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is LIMK2.

UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569
Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic
phase of spermatogenesis (By similarity)

Gene Wiki entry for TESK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TESK1 gene promoter:
         c-Fos   RP58   AP-1   AML1a   STAT5A   Tal-1beta   E47   MZF-1   ITF-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTESK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TESK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TESK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

TESK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TESK1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035605:  view genomic region     (about GC identifiers)

Start:
35,605,281 bp from pter      End:
35,610,038 bp from pter
Size:
4,758 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569 (See protein sequence)
Recommended Name: Dual specificity testis-specific protein kinase 1  
Size: 626 amino acids; 67684 Da
Cofactor: Magnesium (By similarity)
Cofactor: Manganese (By similarity)
Subunit: Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit
activity (By similarity). Interacts with SPRY4
Secondary accessions: Q8IXZ8

Explore the universe of human proteins at neXtProt for TESK1: NX_Q15569

Explore proteomics data for TESK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine and tyrosine residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15569

  • TESK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TESK1 Protein Expression
    REFSEQ proteins: NP_006276.2  
    ENSEMBL proteins: 
     ENSP00000338127  
    Reactome Protein details: Q15569
    Human Recombinant Protein Products for TESK1: 
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    Cloud-Clone Corp. Proteins for TESK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TESK1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific kinase 1 
    TESK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR015782 Testis-specific_kinase_1
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15569

    ProtoNet protein and cluster: Q15569

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569
    Domain: The extracatalytic C-terminal part is highly rich in proline residues
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TESK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TESK1_HUMAN, Q15569
    Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
    substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic
    phase of spermatogenesis (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By
    similarity)

         Genatlas biochemistry entry for TESK1:
    testis specific protein kinase 1,putatively involved in signal transduction

         Enzyme Number (IUBMB): EC 2.7.12.11

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI12027893
         
    TESK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TESK1:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Increased colony dispersion (i  Small cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTESK1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TESK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    2Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.44
    Cell-extracellular matrix interactions0.44
    3Rho Family GTPases
    ILK Signaling0.49
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TESK1
        ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for TESK1
        Cytoskeletal Signaling

    4        Reactome Pathways for TESK1
        Cell-extracellular matrix interactions
    Cell junction organization
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Cell-Cell communication



    TESK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TESK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for TESK1 (Q155691, 3 ENSP000003381274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPRY4Q9C0041, 3, ENSP000003449674EBI-354852,EBI-354861 I2D: score=3 STRING: ENSP00000344967
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    SPRY2O435973, ENSP000003663064I2D: score=2 STRING: ENSP00000366306
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    SPRED1Q7Z6993, ENSP000002990844I2D: score=1 STRING: ENSP00000299084
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007283spermatogenesis IEA--
    GO:0034329cell junction assembly TAS--

    TESK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TESK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TESK1

    4 HMDB Compounds for TESK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    4 Novoseek inferred chemical compound relationships for TESK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 67.3 10 10207045 (3), 15584898 (1), 11294912 (1), 15169836 (1) (see all 6)
    serine 56.6 12 10207045 (4), 15584898 (1), 11294912 (1), 15169836 (1) (see all 6)
    alanine 18.5 1 15584898 (1)
    tyrosine 16.7 6 10207045 (3), 15584898 (1)

    Search CenterWatch for drugs/clinical trials and news about TESK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TESK1 gene: 
    NM_006285.2  

    Unigene Cluster for TESK1:

    Testis-specific kinase 1
    Hs.708096  [show with all ESTs]
    Unigene Representative Sequence: BC038448
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336395(uc003zxa.3 uc010mks.3) ENST00000498522 ENST00000467424
    ENST00000463897 ENST00000480077
    miRNA
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    hsa-miR-203 hsa-miR-34b* hsa-miR-3194-5p hsa-miR-3152-3p hsa-miR-4328 hsa-miR-1203 hsa-miR-4276 hsa-miR-592
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    Additional mRNA sequence: 

    AF452589.1 AF479317.1 AF507907.1 AF507908.1 AF507909.1 AF521045.1 AF521046.1 AF521047.1 
    AF521049.1 AK298907.1 BC011799.2 BC037561.1 BC038448.1 BC067130.1 D50863.1 

    10 DOTS entries:

    DT.315694  DT.100755357  DT.97846514  DT.100755360  DT.100755358  DT.100778017  DT.121160777  DT.95210880 
    DT.95356971  DT.121160771 

    24/151 AceView cDNA sequences (see all 151):

    AF521046 F12646 BF726100 BU633449 BE243553 BI039439 BU632695 AI540853 
    BU180866 BC038448 BM700107 BM055388 AW295637 CR623884 AA749278 BX357087 
    F10261 BQ048980 BC037561 BU737906 BC067130 CD673759 BE783058 AF507907 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TESK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                      -                                             
    SP2:                                            -                                       
    SP3:                                            -                                       


    ECgene alternative splicing isoforms for TESK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TESK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTAACAC
    TESK1 Expression
    About this image


    See TESK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TESK1

    SOURCE GeneReport for Unigene cluster: Hs.708096
        SABiosciences Custom PCR Arrays for TESK1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TESK1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tesk11 , 5 testis specific protein kinase 11, 5 89.89(n)1
    93.87(a)1
      4 (23.04 cM)5
    217541  NM_011571.31  NP_035701.31 
     434419395 
    chicken
    (Gallus gallus)
    Aves LOC4298781 dual specificity testis-specific protein kinase 1-like less 66.12(n)
    64.07(a)
      429878  XM_427433.3  XP_427433.3 
    lizard
    (Anolis carolinensis)
    Reptilia TESK16
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343585.1(250167-269986)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120542 Transcribed sequence with moderate similarity to protein spQ15569 (H.sapiens) TESK_HUMAN Testis-specific protein kinase 1 less 78.72(n)    CF998036.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdi6
    center divider
    19(a)
    1 → many
    3R(14870604-14920076)


    ENSEMBL Gene Tree for TESK1 (if available)
    TreeFam Gene Tree for TESK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TESK1 gene
    LIMK22  TESK22  LIMK12  
    1 SIMAP similar gene for TESK1 using alignment to 1 protein entry:     TESK1_HUMAN:
    TESK2

    TESK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 SNPs in TESK1 are shown (see all 79)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356384
    Breast cancer samples4--see VAR_0356382 H Y mis40--------
    VAR_0412134
    ----see VAR_0412132 G S mis40--------
    rs1925468231,2
    C--35603387(+) CATCAC/TCAACT 1 -- us2k10--------
    rs1175226661,2
    C,F--35603561(+) TGAGCG/ATGTGC 1 -- us2k11Minor allele frequency- A:0.09NA 120
    rs32159951,2
    C,F--35603569(+) TGCTG-/AAGACC 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1391779021,2
    --35603607(+) GCACGG/TGCCCC 1 -- us2k10--------
    rs109725251,2
    C,H--35603736(+) TCTGGC/ACTTCT 1 -- us2k17Minor allele frequency- A:0.00NS EA NA 600
    rs1849249071,2
    --35603801(+) AGCCCA/TCGACA 1 -- us2k10--------
    rs1495406141,2
    --35603851(+) TAACCA/CGACTC 1 -- us2k10--------
    rs1440078521,2
    --35603858(+) ACTCCA/GTTGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TESK1 (35605281 - 35610038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TESK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528256CNV Loss19592680
    esv25703CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601782    OMIM disorders: --

    5 diseases for TESK1:    About MalaCards
    myotonic dystrophy    teratocarcinoma    hepatitis b    hepatitis
    endotheliitis


    TESK1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TESK1 (1 document)

    Export disorders for TESK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TESK1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with TESK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. (PubMed id 8537404)1, 2, 3, 9 Toshima J.... Mizuno K. (1995)
    2. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. (PubMed id 12027893)1, 2, 9 Leeksma O.C.... de Vries C.J.M. (2002)
    3. Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. (PubMed id 15817463)1, 9 LaLonde D.P....Turner C.E. (2005)
    4. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. (PubMed id 11294912)1, 9 Toshima J....Mizuno K. (2001)
    5. Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop. (PubMed id 10207045)1, 9 Toshima J....Mizuno K. (1999)
    6. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PubMed id 11418599)1, 9 Toshima J.... Mizuno K. (2001)
    7. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PubMed id 10512679)1, 9 Rosok O.... Aasheim H.-C. (1999)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7016 HGNC: 11731 AceView: TESK1 Ensembl:ENSG00000107140 euGenes: HUgn7016
    ECgene: TESK1 H-InvDB: TESK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TESK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TESK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TESK1 gene:
    Search GeneIP for patents involving TESK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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