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TESK1 Gene

protein-coding   GIFtS: 57
GCID: GC09P035605

Testis-Specific Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis-Specific Kinase 11 2
Testicular Protein Kinase 12 3
Testis Specific Kinase-11
Testis-Specific Kinase-11
Dual Specificity Testis-Specific Protein Kinase 12
EC 2.7.12.13

External Ids:    HGNC: 117311   Entrez Gene: 70162   Ensembl: ENSG000001071407   OMIM: 6017825   UniProtKB: Q155693   

Export aliases for TESK1 gene to outside databases

Previous GC identifers: GC09P035917 GC09P035774 GC09P035595 GC09P035561


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TESK1 Gene:
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a
C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM
motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone
in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene
suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TESK1 Gene:
TESK1 (testis-specific kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is LIMK2.

UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569
Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic
phase of spermatogenesis (By similarity)

Gene Wiki entry for TESK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TESK1 gene promoter:
         c-Fos   RP58   AP-1   AML1a   STAT5A   Tal-1beta   E47   MZF-1   ITF-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTESK1 promoter sequence
   Search Chromatin IP Primers for TESK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TESK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

TESK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TESK1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035605:  view genomic region     (about GC identifiers)

Start:
35,605,281 bp from pter      End:
35,610,038 bp from pter
Size:
4,758 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569 (See protein sequence)
Recommended Name: Dual specificity testis-specific protein kinase 1  
Size: 626 amino acids; 67684 Da
Cofactor: Magnesium (By similarity)
Cofactor: Manganese (By similarity)
Subunit: Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit
activity (By similarity). Interacts with SPRY4
Secondary accessions: Q8IXZ8

Explore the universe of human proteins at neXtProt for TESK1: NX_Q15569

Explore proteomics data for TESK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine and tyrosine residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TESK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006276.2  
    ENSEMBL proteins: 
     ENSP00000338127  
    Reactome Protein details: Q15569

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific kinase 1
    TESK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR015782 Testis-specific_kinase_1
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q15569

    ProtoNet protein and cluster: Q15569

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: TESK1_HUMAN, Q15569
    Domain: The extracatalytic C-terminal part is highly rich in proline residues
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TESK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TESK1_HUMAN, Q15569
    Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous
    substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic
    phase of spermatogenesis (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By
    similarity)

         Genatlas biochemistry entry for TESK1:
    testis specific protein kinase 1,putatively involved in signal transduction

         Enzyme Number (IUBMB): EC 2.7.12.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI12027893
         
    Find genes that share ontologies with TESK1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TESK1:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Increased colony dispersion (i  Small cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TESK1

    miRNA
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    miRTarBase miRNAs that target TESK1:
    hsa-mir-26b-5p (MIRT029271), hsa-mir-92a-3p (MIRT049152)

    Block miRNA regulation of human, mouse, rat TESK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TESK1 (see all 9):
    hsa-miR-203 hsa-miR-34b* hsa-miR-3194-5p hsa-miR-3152-3p hsa-miR-4328 hsa-miR-1203 hsa-miR-4276 hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidTESK1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TESK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TESK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.00
    Cell-Cell communication0.64
    Cell-extracellular matrix interactions0.00
    2ERK Signaling
    ILK Signaling0.49
    3Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with TESK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TESK1
        ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for TESK1
        Cytoskeletal Signaling

    1 Reactome Pathway for TESK1
        Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TESK1
    Interactions:

        GeneGlobe Interaction Network for TESK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for TESK1 (Q155691, 3 ENSP000003381274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPRY4Q9C0041, 3, ENSP000003449674EBI-354852,EBI-354861 I2D: score=3 STRING: ENSP00000344967
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    SPRY2O435973, ENSP000003663064I2D: score=2 STRING: ENSP00000366306
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    SPRED1Q7Z6993, ENSP000002990844I2D: score=1 STRING: ENSP00000299084
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007283spermatogenesis IEA--
    GO:0034329cell junction assembly TAS--

    Find genes that share ontologies with TESK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TESK1

    4 HMDB Compounds for TESK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    4 Novoseek inferred chemical compound relationships for TESK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 67.3 10 10207045 (3), 15584898 (1), 11294912 (1), 15169836 (1) (see all 6)
    serine 56.6 12 10207045 (4), 15584898 (1), 11294912 (1), 15169836 (1) (see all 6)
    alanine 18.5 1 15584898 (1)
    tyrosine 16.7 6 10207045 (3), 15584898 (1)



    Find genes that share compounds with TESK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TESK1 gene: 
    NM_006285.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336395(uc003zxa.3 uc010mks.3) ENST00000498522 ENST00000467424
    ENST00000463897 ENST00000480077
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    hsa-miR-203 hsa-miR-34b* hsa-miR-3194-5p hsa-miR-3152-3p hsa-miR-4328 hsa-miR-1203 hsa-miR-4276 hsa-miR-592
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    Selected AceView cDNA sequences (see all 151):

    AI540853 AF521045 BQ048980 BC011799 CN482536 AA461506 BU633449 BM055388 
    BC067130 BC038448 BI039439 AA749278 BM700107 BC037561 AF507907 AF521046 
    BU632695 BE783058 F10261 BF726100 BE243553 BU180866 CR623884 CD673759 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TESK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                      -                                             
    SP2:                                            -                                       
    SP3:                                            -                                       


    ECgene alternative splicing isoforms for TESK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TESK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTAACAC
    TESK1 Expression
    About this image

    TESK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TESK1 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TESK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tesk11 , 5 testis specific protein kinase 11, 5 89.38(n)1
    93.19(a)1
      4 (23.04 cM)5
    217541  NM_011571.31  NP_035701.31 
     434419395 
    chicken
    (Gallus gallus)
    Aves TESK11 testis-specific kinase 1 67.25(n)
    66.03(a)
      429878  XM_427433.4  XP_427433.4 
    lizard
    (Anolis carolinensis)
    Reptilia TESK16
    testis-specific kinase 1
    53(a)
    1 ↔ 1
    GL343585.1(250167-269986)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120542 Transcribed sequence with moderate similarity to protein spQ15569 (H.sapiens) TESK_HUMAN Testis-specific protein kinase 1 less 78.72(n)    CF998036.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdi6
    center divider
    21(a)
    1 → many
    3R(14870604-14920076)
    worm
    (Caenorhabditis elegans)
    Secernentea T25B9.56
    Y69E1A.36
    (see all 5)
    Protein Y69E1A.3 (Y69E1A.3) mRNA, complete cds
    (see all 5)
    17(a)
    17(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    IV(10752430-10754589) WBGene00012011
    IV(10952359-10954686) WBGene00013475


    ENSEMBL Gene Tree for TESK1 (if available)
    TreeFam Gene Tree for TESK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TESK1 gene
    LIMK22  TESK22  LIMK12  
    1 SIMAP similar gene for TESK1 using alignment to 1 protein entry:     TESK1_HUMAN:
    TESK2

    Find genes that share paralogs with TESK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TESK1 (see all 79)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356384
    Breast cancer samples4--see VAR_0356382 H Y mis40--------
    rs1925468231,2
    C--35603387(+) CATCAC/TCAACT 1 -- us2k10--------
    rs1175226661,2
    C,F--35603561(+) TGAGCG/ATGTGC 1 -- us2k11Minor allele frequency- A:0.09NA 120
    rs32159951,2
    C,F--35603569(+) TGCTG-/AAGACC 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1391779021,2
    --35603607(+) GCACGG/TGCCCC 1 -- us2k10--------
    rs109725251,2
    C,H--35603736(+) TCTGGC/ACTTCT 1 -- us2k17Minor allele frequency- A:0.00NS EA NA 600
    rs1849249071,2
    --35603801(+) AGCCCA/TCGACA 1 -- us2k10--------
    rs1495406141,2
    --35603851(+) TAACCA/CGACTC 1 -- us2k10--------
    rs1440078521,2
    --35603858(+) ACTCCA/GTTGGA 1 -- us2k10--------
    rs1888384291,2
    --35603956(+) TCCTGC/TAGGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TESK1 (35605281 - 35610038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TESK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528256CNV Loss19592680
    esv25703CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601782    OMIM disorders: --


    Find genes that share disorders with TESK1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TESK1 (1 document)

    Export disorders for TESK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TESK1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TESK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. (PubMed id 8537404)1, 2, 3, 9 Toshima J.... Mizuno K. (J. Biol. Chem. 1995)
    2. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. (PubMed id 12027893)1, 2, 9 Leeksma O.C.... de Vries C.J.M. (Eur. J. Biochem. 2002)
    3. Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. (PubMed id 15817463)1, 9 LaLonde D.P....Turner C.E. (J. Biol. Chem. 2005)
    4. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. (PubMed id 11294912)1, 9 Toshima J....Mizuno K. (Mol. Biol. Cell 2001)
    5. Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop. (PubMed id 10207045)1, 9 Toshima J....Mizuno K. (J. Biol. Chem. 1999)
    6. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PubMed id 11418599)1, 9 Toshima J.... Mizuno K. (J. Biol. Chem. 2001)
    7. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PubMed id 10512679)1, 9 Rosok O.... Aasheim H.-C. (Genomics 1999)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7016 HGNC: 11731 AceView: TESK1 Ensembl:ENSG00000107140 euGenes: HUgn7016
    ECgene: TESK1 H-InvDB: TESK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TESK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TESK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TESK1 gene:
    Search GeneIP for patents involving TESK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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