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Aliases for TESC Gene

Aliases for TESC Gene

  • Tescalcin 2 3 4 5
  • Calcineurin-Like EF Hand Protein 3 2 3
  • CHP3 3 4
  • TSC 3 4

External Ids for TESC Gene

Previous GeneCards Identifiers for TESC Gene

  • GC12M115961
  • GC12M117477
  • GC12M114485

Summaries for TESC Gene

GeneCards Summary for TESC Gene

TESC (Tescalcin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and magnesium ion binding.

UniProtKB/Swiss-Prot for TESC Gene

  • Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESC Gene

Genomics for TESC Gene

Regulatory Elements for TESC Gene

Enhancers for TESC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TESC on UCSC Golden Path with GeneCards custom track

Promoters for TESC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TESC on UCSC Golden Path with GeneCards custom track

Genomic Location for TESC Gene

Chromosome:
12
Start:
117,038,923 bp from pter
End:
117,099,479 bp from pter
Size:
60,557 bases
Orientation:
Minus strand

Genomic View for TESC Gene

Genes around TESC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESC Gene

Proteins for TESC Gene

  • Protein details for TESC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BS2-CHP3_HUMAN
    Recommended name:
    Calcineurin B homologous protein 3
    Protein Accession:
    Q96BS2
    Secondary Accessions:
    • F5H1Y5
    • Q9NWT9

    Protein attributes for TESC Gene

    Size:
    214 amino acids
    Molecular mass:
    24750 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1 (via juxtamembrane region of the cytoplasmic C-terminus); the interaction enable an optimal Na(+)/H(+) exchange activity.
    SequenceCaution:
    • Sequence=BAA91288.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW98101.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TESC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESC Gene

Proteomics data for TESC Gene at MOPED

Post-translational modifications for TESC Gene

  • Ubiquitination at Lys 33
  • Modification sites at PhosphoSitePlus

Other Protein References for TESC Gene

No data available for DME Specific Peptides for TESC Gene

Domains & Families for TESC Gene

Gene Families for TESC Gene

Protein Domains for TESC Gene

Suggested Antigen Peptide Sequences for TESC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BS2

UniProtKB/Swiss-Prot:

CHP3_HUMAN :
  • Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Domain:
  • Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
genes like me logo Genes that share domains with TESC: view

Function for TESC Gene

Molecular function for TESC Gene

UniProtKB/Swiss-Prot Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during granulocytic differentiation in a ERK-dependent manner (is mediated by activation of ERK) (at protein level). Up-regulated during the differentiation and maturation of primary megakaryocytes. Down-regulated during monocytic-macrophage differentiation in a ERK-dependent manner.

Gene Ontology (GO) - Molecular Function for TESC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11696366
genes like me logo Genes that share ontologies with TESC: view
genes like me logo Genes that share phenotypes with TESC: view

Animal Models for TESC Gene

MGI Knock Outs for TESC:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TESC Gene

Localization for TESC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESC Gene

Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269 PubMed:18321853}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TESC Gene COMPARTMENTS Subcellular localization image for TESC gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TESC Gene

Pathways & Interactions for TESC Gene

SuperPathways for TESC Gene

No Data Available

Gene Ontology (GO) - Biological Process for TESC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0032417 positive regulation of sodium:proton antiporter activity IDA 18321853
GO:0045654 positive regulation of megakaryocyte differentiation IMP 17717601
GO:0045893 positive regulation of transcription, DNA-templated IMP 17717601
GO:0072661 protein targeting to plasma membrane IDA 18321853
genes like me logo Genes that share ontologies with TESC: view

No data available for Pathways by source and SIGNOR curated interactions for TESC Gene

Drugs & Compounds for TESC Gene

(1) Drugs for TESC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for TESC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with TESC: view

Transcripts for TESC Gene

Unigene Clusters for TESC Gene

Tescalcin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TESC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: - -

Relevant External Links for TESC Gene

GeneLoc Exon Structure for
TESC
ECgene alternative splicing isoforms for
TESC

Expression for TESC Gene

mRNA expression in normal human tissues for TESC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TESC Gene

This gene is overexpressed in Whole Blood (x8.0), Brain - Putamen (basal ganglia) (x4.3), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for TESC Gene

This gene is overexpressed in Skin (22.6), Salivary gland (16.2), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TESC Gene



SOURCE GeneReport for Unigene cluster for TESC Gene Hs.525709

mRNA Expression by UniProt/SwissProt for TESC Gene

Q96BS2-CHP3_HUMAN
Tissue specificity: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
genes like me logo Genes that share expression patterns with TESC: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TESC Gene

Orthologs for TESC Gene

This gene was present in the common ancestor of chordates.

Orthologs for TESC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TESC 35
  • 92.06 (n)
  • 97.2 (a)
TESC 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TESC 35
  • 91.58 (n)
  • 95.96 (a)
TESC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tesc 35
  • 90.81 (n)
  • 96.73 (a)
Tesc 16
Tesc 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TESC 35
  • 99.84 (n)
  • 99.53 (a)
TESC 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tesc 35
  • 90.34 (n)
  • 96.73 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TESC 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TESC 35
  • 76.32 (n)
  • 70.56 (a)
TESC 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TESC 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tesc 35
  • 68.39 (n)
  • 72.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24323 35
zebrafish
(Danio rerio)
Actinopterygii tescb 35
  • 60.09 (n)
  • 56.34 (a)
tesca 36
  • 50 (a)
OneToMany
tescb 36
  • 55 (a)
OneToMany
Species with no ortholog for TESC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TESC Gene

ENSEMBL:
Gene Tree for TESC (if available)
TreeFam:
Gene Tree for TESC (if available)

Paralogs for TESC Gene

(3) SIMAP similar genes for TESC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TESC: view

No data available for Paralogs for TESC Gene

Variants for TESC Gene

Sequence variations from dbSNP and Humsavar for TESC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2062526 -- 117,056,488(-) GGCTG(C/T)GGTGG intron-variant
rs2062527 -- 117,056,323(-) tccca(C/G)cactt intron-variant
rs2062528 -- 117,042,419(-) GGCCA(C/G)ACCTA intron-variant
rs2062529 -- 117,042,205(-) AGCCC(A/G)TGAAT intron-variant
rs7134123 -- 117,093,345(+) GCCAC(A/G)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TESC Gene

Variant ID Type Subtype PubMed ID
nsv832524 CNV Gain 17160897
nsv519118 CNV Loss 19592680
nsv899541 CNV Loss 21882294
nsv832526 CNV Loss 17160897

Variation tolerance for TESC Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TESC Gene

HapMap Linkage Disequilibrium report
TESC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESC Gene

Disorders for TESC Gene

Relevant External Links for TESC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TESC

No disorders were found for TESC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESC Gene

Publications for TESC Gene

  1. Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. (PMID: 11696366) Mailaender J. … Dedio J. (FEBS Lett. 2001) 2 3 4 23 67
  2. The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin. (PMID: 12809501) Li X. … Fliegel L. (Biochemistry 2003) 2 3 23
  3. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. (PMID: 20060826) Levay K. … Slepak V.Z. (Exp. Cell Res. 2010) 3 23
  4. Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. (PMID: 17717601) Levay K. … Slepak V.Z. (J. Clin. Invest. 2007) 3 23
  5. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. (PMID: 14661968) Gutierrez-Ford C. … Slepak V.Z. (Biochemistry 2003) 2 3

Products for TESC Gene

Sources for TESC Gene

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