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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TESC Gene

protein-coding   GIFtS: 49
GCID: GC12M117477

Tescalcin

  Search for TESC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tescalcin3
tescalcin1 2
TSC2 3 5
Calcineurin-Like EF Hand Protein 31 2
CHP32 3
Calcineurin B Homologous Protein 32

External Ids:    HGNC: 260651   Entrez Gene: 549972   Ensembl: ENSG000000889927   OMIM: 6115855   UniProtKB: Q96BS23   
ORGUL members:         
NONCODE14:n409060      

Export aliases for TESC gene to outside databases

Previous GC identifers: GC12M115961 GC12M114485


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TESC Gene: 
TESC (tescalcin) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include magnesium ion binding and calcium ion binding.

UniProtKB/Swiss-Prot: CHP3_HUMAN, Q96BS2
Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+)
exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of
SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward
megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family
genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner.
Inhibits the phosphatase activity of calcineurin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TESC gene promoter:
         HOXA9B   HOXA9   AP-2rep   Meis-1b   Arnt   HEN1   N-Myc   FAC1   HSF2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTESC promoter sequence
   Search SABiosciences Chromatin IP Primers for TESC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TESC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.22

TESC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TESC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117477:  view genomic region     (about GC identifiers)

Start:
117,476,728 bp from pter      End:
117,537,284 bp from pter
Size:
60,557 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHP3_HUMAN, Q96BS2 (See protein sequence)
Recommended Name: Calcineurin B homologous protein 3  
Size: 214 amino acids; 24750 Da
Subunit: Monomer. Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1 (via juxtamembrane
region of the cytoplasmic C-terminus); the interaction enable an optimal Na(+)/H(+) exchange activity
Subcellular location: Nucleus. Cytoplasm. Membrane (By similarity). Cell membrane. Cell projection, lamellipodium
(By similarity). Cell projection, ruffle membrane (By similarity). Note=Colocalizes with SLC9A1 at the plasma
membrane
Developmental stage: Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation,
but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid
differentiation (at protein level)
Caution: Although PubMed:12809501 reports that TESC results in a decrease in transporter activity of human SLC9A1,
studies with rat SLC9A1 (PubMed:18321853) show that TESC-binding results in the maturation and accumulation of
SLC9A1 at the cell surface
Sequence caution: Sequence=BAA91288.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=EAW98101.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: F5H1Y5 Q9NWT9
Alternative splicing: 3 isoforms:  Q96BS2-1   Q96BS2-2   Q96BS2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TESC: NX_Q96BS2

Explore proteomics data for TESC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BS2

  • TESC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TESC Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001161797.1  NP_060369.3  

    ENSEMBL proteins: 
     ENSP00000432716   ENSP00000334785   ENSP00000450386   ENSP00000432608   ENSP00000376328  
     ENSP00000445689  

    Human Recombinant Protein Products for TESC: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA18321853
    GO:0005886plasma membrane IDA18321853
    GO:0030027lamellipodium IDA11696366

    TESC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q96BS2

    ProtoNet protein and cluster: Q96BS2

    UniProtKB/Swiss-Prot: CHP3_HUMAN, Q96BS2
    Domain: Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium
    (By similarity)
    Similarity: Belongs to the calcineurin regulatory subunit family. CHP subfamily
    Similarity: Contains 1 EF-hand domain


    TESC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHP3_HUMAN, Q96BS2
    Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+)
    exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of
    SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward
    megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family
    genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner.
    Inhibits the phosphatase activity of calcineurin
    Induction: Up-regulated during granulocytic differentiation in a ERK-dependent manner (is mediated by activation
    of ERK) (at protein level). Up-regulated during the differentiation and maturation of primary megakaryocytes.
    Down-regulated during monocytic-macrophage differentiation in a ERK-dependent manner

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005509calcium ion binding IDA11696366
    GO:0005515protein binding IPI11696366
    GO:0019212phosphatase inhibitor activity ISS--
         
    TESC for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tesc):
     hematopoietic system 

    TESC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tesctm1Itl for TESC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TESC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TESC

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    miRNA
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    hsa-miR-577 hsa-miR-495 hsa-miR-548d-3p hsa-miR-548am hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidTESC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TESC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for TESC (Q96BS21, 2, 3 ENSP000003763284) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMG20AQ9NP661, 2, 3, ENSP000003368564EBI-740653,EBI-740641 MINT-66093 I2D: score=5 STRING: ENSP00000336856
    CCDC91Q7Z6B02, 3, ENSP000003706584MINT-66668 I2D: score=4 STRING: ENSP00000370658
    DYNLT3P518082, 3, ENSP000003678414MINT-67428 I2D: score=4 STRING: ENSP00000367841
    RAI1Q7Z5J42, 3, ENSP000003230744MINT-66449 I2D: score=4 STRING: ENSP00000323074
    SLC9A1P196343, ENSP000002639804I2D: score=1 STRING: ENSP00000263980
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IMP17717601
    GO:0008584male gonad development IEA--
    GO:0010628positive regulation of gene expression IMP17717601
    GO:0030219megakaryocyte differentiation IEA--
    GO:0030854positive regulation of granulocyte differentiation IDA--

    TESC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TESC (CHP3)

    2 HMDB Compounds for TESC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about TESC / CHP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TESC gene (2 alternative transcripts): 
    NM_001168325.1  NM_017899.3  

    Unigene Cluster for TESC:

    Tescalcin
    Hs.525709  [show with all ESTs]
    Unigene Representative Sequence: BQ650973
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470612(uc001twi.3 uc001twh.3 uc021rem.1) ENST00000335209
    ENST00000549210 ENST00000462502 ENST00000535198 ENST00000482176 ENST00000552139
    ENST00000392545 ENST00000541210
    miRNA
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    hsa-miR-577 hsa-miR-495 hsa-miR-548d-3p hsa-miR-548am hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidTESC 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TESC
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    Additional mRNA sequence: 

    AF443207.1 BC015221.1 NR_031766.2 

    8 DOTS entries:

    DT.444553  DT.75111470  DT.75100725  DT.87015936  DT.40109113  DT.92425682  DT.95166515  DT.97776716 

    24/134 AceView cDNA sequences (see all 134):

    BM784014 BM756352 BM765355 AA625575 AA515518 BM694011 AI674147 BM695003 
    BI823634 CB144334 BM854715 BQ434057 BM784824 BX097003 BQ957077 BE856158 
    AI332605 BQ949772 AI031618 BU175874 BM783978 BM127110 AA354111 BC015221 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TESC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                       -     -                                 
    SP2:                    -                       -     -                                 
    SP3:                    -           -           -     -                                 
    SP4:                                                                                    
    SP5:                    -                       -                                       


    ECgene alternative splicing isoforms for TESC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TESC expression in normal human tissues (normalized intensities)      TESC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCTGCC
    TESC Expression
    About this image


    TESC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Fetal Liver CD36+ Cells   
             monocytes   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Collecting Duct Cells Renal Collecting Duct System
             Metanephros
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See TESC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TESC

    SOURCE GeneReport for Unigene cluster: Hs.525709

    UniProtKB/Swiss-Prot: CHP3_HUMAN, Q96BS2
    Tissue specificity: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level).
    Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the
    placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TESC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TESC gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tesc1 , 5 tescalcin1, 5 90.81(n)1
    96.73(a)1
      5 (57.84 cM)5
    578161  NM_021344.31  NP_067319.21 
     1180277435 
    chicken
    (Gallus gallus)
    Aves TESC1 tescalcin 76.32(n)
    70.56(a)
      771113  NM_001080884.1  NP_001074353.1 
    lizard
    (Anolis carolinensis)
    Reptilia TESC6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    LGb(2373786-2386431)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243232 Xenopus laevis transcribed sequence with weak similarity more 74.44(n)    CB200958.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tescb1 tescalcin b 60.25(n)
    56.34(a)
      402993  NM_205693.1  NP_991256.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG328126
    --
    20(a)
    1 ↔ 1
    X(1181323-1182978)


    ENSEMBL Gene Tree for TESC (if available)
    TreeFam Gene Tree for TESC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TESC gene
    4 SIMAP similar genes for TESC using alignment to 4 protein entries:     CHP3_HUMAN (see all proteins):
    CHP1    CHP2    LOC63928    PPP3R1

    TESC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1481 SNPs in TESC are shown (see all 1481)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs803002481,2
    C,F--117476237(+) AACACG/AGATGG 3 -- int14Minor allele frequency- A:0.12WA CSA 124
    rs1930828991,2
    --117476315(+) TCTGCC/TAAACC 3 -- int10--------
    rs734032611,2
    C,F--117476320(+) CAAACC/TAACCT 3 -- int13Minor allele frequency- T:0.12WA NA 240
    rs1849475011,2
    --117476370(+) TAATCC/TTAGCA 3 -- int10--------
    rs1162928231,2
    C,F--117476441(+) ACATAT/GTAAGA 3 -- int13Minor allele frequency- G:0.14WA NA EA 358
    rs734032641,2
    C,F--117476570(+) TGAGCC/TGTGAT 3 -- int12Minor allele frequency- T:0.10WA NA 238
    rs1457649321,2
    C--117476661(+) CCTCAG/TAGTCA 3 -- int10--------
    rs1489422741,2
    --117476704(+) ATGGAC/TGTGAG 3 -- int10--------
    rs1888819981,2
    --117476725(+) AGGCCA/GCATTA 3 -- int10--------
    rs1816647681,2
    --117476792(+) CCATAC/TCCTAC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TESC (117476728 - 117537284 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TESC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832526CNV Loss17160897
    nsv899541CNV Loss21882294
    nsv519118CNV Loss19592680
    nsv832524CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TESC for disorders           About MalaCards
    OMIM gene information: 611585    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TESC:
    Spindle cell hemangioma

    TESC for disorders           About GeneDecksing


    Export disorders for TESC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TESC gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TESC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. (PubMed id 11696366)1, 2, 3, 9 Mailaender J.... Dedio J. (2001)
    2. The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin. (PubMed id 12809501)1, 2, 3, 9 Li X....Fliegel L. (2003)
    3. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. (PubMed id 14661968)1, 2, 3 Gutierrez-Ford C....Slepak V.Z. (2003)
    4. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. (PubMed id 20060826)1, 2, 9 Levay K. and Slepak V.Z. (2010)
    5. Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. (PubMed id 17717601)1, 2, 9 Levay K. and Slepak V.Z. (2007)
    6. Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. (PubMed id 18321853)1, 2 Zaun H.C.... Orlowski J. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. (PubMed id 11145610)1, 3 Perera E.M....Berkovitz G.D. (2001)
    9. N-myristoylation and Ca2+ binding of calcineurin B hom ologous protein CHP3 are required to enhance Na+/H+ exchanger NHE1 half-life and activity at the plasma membrane. (PubMed id 22984264)1 Zaun H.C....Orlowski J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54997 HGNC: 26065 AceView: TSC Ensembl:ENSG00000088992 euGenes: HUgn54997
    ECgene: TESC H-InvDB: TESC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TESC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TESC gene:
    Search GeneIP for patents involving TESC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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