Aliases for TESC Gene
External Ids for TESC Gene
Previous GeneCards Identifiers for TESC Gene
GeneCards Summary for TESC Gene
TESC (Tescalcin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is CHP1.
UniProtKB/Swiss-Prot for TESC Gene
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.