Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TESC Gene

Aliases for TESC Gene

  • Tescalcin 2 3 4 5
  • Calcineurin-Like EF Hand Protein 3 2 3
  • CHP3 3 4
  • TSC 3 4
  • Calcineurin B Homologous Protein 3 3

External Ids for TESC Gene

Previous GeneCards Identifiers for TESC Gene

  • GC12M115961
  • GC12M117477
  • GC12M114485

Summaries for TESC Gene

GeneCards Summary for TESC Gene

TESC (Tescalcin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for TESC Gene

  • Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESC Gene

Genomics for TESC Gene

Regulatory Elements for TESC Gene

Enhancers for TESC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G117041 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +56.8 56797 1.9 HDGF PKNOX1 CREB3L1 ARNT ZNF766 FOS KLF13 JUNB REST ZNF592 TESC FBXW8 GC12M117031 TESC-AS1
GH12G117044 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +53.7 53663 2.9 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 ZNF766 SP5 PPARG KAT8 TESC FBXW8 GC12M117031 TESC-AS1
GH12G117047 1.2 ENCODE dbSUPER 18.5 +51.0 51035 1.5 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SP5 MXD4 PPARG TESC FBXW8 GC12M117031 TESC-AS1
GH12G117050 0.9 FANTOM5 ENCODE dbSUPER 18.8 +48.4 48432 0.2 NR4A1 TESC FBXW8 GC12M117031 TESC-AS1
GH12G117052 1.1 Ensembl ENCODE dbSUPER 12.4 +46.7 46727 1.3 ESRRA ZMYM3 RELB EBF1 KDM1A RELA CHD2 TESC FBXW8 GC12M117031 TESC-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TESC on UCSC Golden Path with GeneCards custom track

Promoters for TESC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058096 379 1001 MLX AGO1 SIN3A ZNF143 SP3 REST ZNF592 ZNF579 MIER3 KDM1A

Genomic Location for TESC Gene

Chromosome:
12
Start:
117,038,923 bp from pter
End:
117,099,479 bp from pter
Size:
60,557 bases
Orientation:
Minus strand

Genomic View for TESC Gene

Genes around TESC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESC Gene

Proteins for TESC Gene

  • Protein details for TESC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BS2-CHP3_HUMAN
    Recommended name:
    Calcineurin B homologous protein 3
    Protein Accession:
    Q96BS2
    Secondary Accessions:
    • F5H1Y5
    • Q9NWT9

    Protein attributes for TESC Gene

    Size:
    214 amino acids
    Molecular mass:
    24750 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1 (via juxtamembrane region of the cytoplasmic C-terminus); the interaction enable an optimal Na(+)/H(+) exchange activity.
    SequenceCaution:
    • Sequence=BAA91288.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW98101.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TESC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESC Gene

Post-translational modifications for TESC Gene

  • Ubiquitination at Lys33
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TESC Gene

Domains & Families for TESC Gene

Gene Families for TESC Gene

Protein Domains for TESC Gene

Suggested Antigen Peptide Sequences for TESC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BS2

UniProtKB/Swiss-Prot:

CHP3_HUMAN :
  • Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Domain:
  • Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
genes like me logo Genes that share domains with TESC: view

Function for TESC Gene

Molecular function for TESC Gene

UniProtKB/Swiss-Prot Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during granulocytic differentiation in a ERK-dependent manner (is mediated by activation of ERK) (at protein level). Up-regulated during the differentiation and maturation of primary megakaryocytes. Down-regulated during monocytic-macrophage differentiation in a ERK-dependent manner.

Gene Ontology (GO) - Molecular Function for TESC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005509 calcium ion binding IDA 11696366
GO:0005515 protein binding IPI 11696366
GO:0019212 phosphatase inhibitor activity ISS --
genes like me logo Genes that share ontologies with TESC: view
genes like me logo Genes that share phenotypes with TESC: view

Animal Models for TESC Gene

MGI Knock Outs for TESC:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TESC Gene

Localization for TESC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESC Gene

Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269 PubMed:18321853}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESC gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TESC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005634 nucleus ISS,IEA --
GO:0005737 cytoplasm IDA,IEA 18321853
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA 18321853
genes like me logo Genes that share ontologies with TESC: view

Pathways & Interactions for TESC Gene

No Data Available

Gene Ontology (GO) - Biological Process for TESC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006810 transport IEA --
GO:0008285 negative regulation of cell proliferation IMP 17717601
GO:0008584 male gonad development IEA --
GO:0010628 positive regulation of gene expression IMP 17717601
genes like me logo Genes that share ontologies with TESC: view

No data available for Pathways by source and SIGNOR curated interactions for TESC Gene

Drugs & Compounds for TESC Gene

(1) Drugs for TESC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for TESC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with TESC: view

Transcripts for TESC Gene

Unigene Clusters for TESC Gene

Tescalcin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: - -

Relevant External Links for TESC Gene

GeneLoc Exon Structure for
TESC
ECgene alternative splicing isoforms for
TESC

Expression for TESC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TESC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TESC Gene

This gene is overexpressed in Whole Blood (x8.0), Brain - Putamen (basal ganglia) (x4.3), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for TESC Gene

This gene is overexpressed in Skin (22.6), Salivary gland (16.2), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TESC Gene



NURSA nuclear receptor signaling pathways regulating expression of TESC Gene:

TESC

SOURCE GeneReport for Unigene cluster for TESC Gene:

Hs.525709

mRNA Expression by UniProt/SwissProt for TESC Gene:

Q96BS2-CHP3_HUMAN
Tissue specificity: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.

Evidence on tissue expression from TISSUES for TESC Gene

  • Lung(2.1)
genes like me logo Genes that share expression patterns with TESC: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESC Gene

Orthologs for TESC Gene

This gene was present in the common ancestor of chordates.

Orthologs for TESC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TESC 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia TESC 34 35
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia TESC 34 35
  • 91.58 (n)
mouse
(Mus musculus)
Mammalia Tesc 34 16 35
  • 90.81 (n)
rat
(Rattus norvegicus)
Mammalia Tesc 34
  • 90.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TESC 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TESC 34 35
  • 76.32 (n)
lizard
(Anolis carolinensis)
Reptilia TESC 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tesc 34
  • 68.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24323 34
zebrafish
(Danio rerio)
Actinopterygii tescb 34 35
  • 60.09 (n)
tesca 35
  • 50 (a)
OneToMany
Species where no ortholog for TESC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TESC Gene

ENSEMBL:
Gene Tree for TESC (if available)
TreeFam:
Gene Tree for TESC (if available)

Paralogs for TESC Gene

Paralogs for TESC Gene

(3) SIMAP similar genes for TESC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TESC: view

Variants for TESC Gene

Sequence variations from dbSNP and Humsavar for TESC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000027491 -- 117,071,857(+) ACTCA(A/C)CCATG intron-variant
rs1000064354 -- 117,069,323(+) CGACC(C/T)CTCCC intron-variant
rs1000156292 -- 117,064,603(+) CCTTA(C/T)GGGGA intron-variant
rs1000178817 -- 117,069,144(+) GCCAC(A/C)GAAAT intron-variant
rs1000190171 -- 117,049,391(+) GTGGA(-/AG)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TESC Gene

Variant ID Type Subtype PubMed ID
esv3549841 CNV deletion 23714750
esv3630863 CNV gain 21293372
nsv519118 CNV loss 19592680
nsv832524 CNV gain 17160897
nsv832526 CNV loss 17160897

Variation tolerance for TESC Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TESC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESC Gene

Disorders for TESC Gene

Relevant External Links for TESC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TESC

No disorders were found for TESC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESC Gene

Publications for TESC Gene

  1. The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin. (PMID: 12809501) Li X. … Fliegel L. (Biochemistry 2003) 2 3 4 22 64
  2. Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. (PMID: 11696366) Mailaender J. … Dedio J. (FEBS Lett. 2001) 2 3 4 22 64
  3. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. (PMID: 20060826) Levay K. … Slepak V.Z. (Exp. Cell Res. 2010) 3 4 22 64
  4. Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. (PMID: 17717601) Levay K. … Slepak V.Z. (J. Clin. Invest. 2007) 3 4 22 64
  5. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. (PMID: 14661968) Gutierrez-Ford C. … Slepak V.Z. (Biochemistry 2003) 2 3 4 64

Products for TESC Gene

Sources for TESC Gene

Content
Loading form....