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Aliases for TES Gene

Aliases for TES Gene

  • Testin LIM Domain Protein 2 3 5
  • Testis Derived Transcript (3 LIM Domains) 2 3
  • TESS 3 4
  • TESS-2 3
  • Testin 3

External Ids for TES Gene

Previous GeneCards Identifiers for TES Gene

  • GC07P114328
  • GC07P115391
  • GC07P115405
  • GC07P115444
  • GC07P115637
  • GC07P115850
  • GC07P110216

Summaries for TES Gene

Entrez Gene Summary for TES Gene

  • Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for TES Gene

TES (Testin LIM Domain Protein) is a Protein Coding gene. Diseases associated with TES include Louping Ill and Diphyllobothriasis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LMCD1.

UniProtKB/Swiss-Prot for TES Gene

  • Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Gene Wiki entry for TES Gene

Additional gene information for TES Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TES Gene

Genomics for TES Gene

Regulatory Elements for TES Gene

Enhancers for TES Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H116209 1.7 Ensembl ENCODE dbSUPER 19.8 +4.3 4268 10 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610 GLIS1 ST7-AS1 TES LOC102724407 LOC100506489 ENSG00000228368 LINC01392 TFEC LOC102724434 ENSG00000279086 GC07P116253
GH07H116165 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -44.4 -44400 1.4 BACH1 BATF RELA ZNF316 NFE2 ATF7 RUNX3 IKZF2 CREM MAFK TES TFEC
GH07H116180 0.9 Ensembl ENCODE 18.7 -30.0 -30030 0.3 CTCF ZNF654 TRIM22 REST ZNF2 RAD21 RFX5 CC2D1A FOXK2 SMC3 TES TFEC ENSG00000235427
GH07H116417 1.5 Ensembl ENCODE dbSUPER 11.1 +207.4 207447 1.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 MCM3 NCOA1 ZC3H11A TES CAV1 ENSG00000235427 ENSG00000243243 ENSG00000243220 PIR33191 ENSG00000237813
GH07H116876 1.6 Ensembl ENCODE dbSUPER 10.4 +666.7 666690 1.9 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 ZC3H11A ST7-AS1 ENSG00000243243 MET TES LOC100418716 GC07M116910 ENSG00000252115
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TES on UCSC Golden Path with GeneCards custom track

Promoters for TES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217069 907 2401 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Locations for TES Gene

Genomic Locations for TES Gene
chr7:116,210,493-116,258,786
(GRCh38/hg38)
Size:
48,294 bases
Orientation:
Plus strand
chr7:115,850,547-115,898,837
(GRCh37/hg19)

Genomic View for TES Gene

Genes around TES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TES Gene

Proteins for TES Gene

  • Protein details for TES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGI8-TES_HUMAN
    Recommended name:
    Testin
    Protein Accession:
    Q9UGI8
    Secondary Accessions:
    • A4D0U6
    • Q9GZQ1
    • Q9HAJ9

    Protein attributes for TES Gene

    Size:
    421 amino acids
    Molecular mass:
    47996 Da
    Quaternary structure:
    • Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.

    Three dimensional structures from OCA and Proteopedia for TES Gene

    Alternative splice isoforms for TES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TES Gene

Post-translational modifications for TES Gene

  • Ubiquitination at posLast=7171 and Lys102
  • Modification sites at PhosphoSitePlus

Other Protein References for TES Gene

No data available for DME Specific Peptides for TES Gene

Domains & Families for TES Gene

Gene Families for TES Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9UGI8

UniProtKB/Swiss-Prot:

TES_HUMAN :
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with TES: view

Function for TES Gene

Molecular function for TES Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Phenotypes From GWAS Catalog for TES Gene

Gene Ontology (GO) - Molecular Function for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21278383
GO:0008270 zinc ion binding IDA 21278383
GO:0045296 cadherin binding IDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TES: view

Phenotypes for TES Gene

MGI mutant phenotypes for TES:
inferred from 2 alleles
GenomeRNAi human phenotypes for TES:
genes like me logo Genes that share phenotypes with TES: view

Animal Models for TES Gene

MGI Knock Outs for TES:

Animal Model Products

CRISPR Products

miRNA for TES Gene

miRTarBase miRNAs that target TES

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TES Gene

Localization for TES Gene

Subcellular locations from UniProtKB/Swiss-Prot for TES Gene

Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TES gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Focal adhesion sites (4)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IEA,IDA 21423176
genes like me logo Genes that share ontologies with TES: view

Pathways & Interactions for TES Gene

No Data Available

Gene Ontology (GO) - Biological Process for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IMP 11420696
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TES: view

No data available for Pathways by source and SIGNOR curated interactions for TES Gene

Drugs & Compounds for TES Gene

(5) Drugs for TES Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator 2826
Triamcinolone Approved, Vet_approved Pharma Agonist 534
triamcinolone acetonide Pharma Agonist 534
Triamcinolone diacetate Pharma 534
Triamcinolone hexacetonide Pharma 534
genes like me logo Genes that share compounds with TES: view

Transcripts for TES Gene

Unigene Clusters for TES Gene

Testis derived transcript (3 LIM domains):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TES Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for TES Gene

GeneLoc Exon Structure for
TES
ECgene alternative splicing isoforms for
TES

Expression for TES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TES Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for TES Gene

This gene is overexpressed in Rectum (9.9), Colon (8.9), and Uterus (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TES Gene



Protein tissue co-expression partners for TES Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TES Gene:

TES

SOURCE GeneReport for Unigene cluster for TES Gene:

Hs.592286

mRNA Expression by UniProt/SwissProt for TES Gene:

Q9UGI8-TES_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TES Gene

  • Skin(2.9)
  • Heart(2.7)
  • Intestine(2.6)
  • Thyroid gland(2.5)
  • Blood(2.4)
  • Nervous system(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TES: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TES Gene

Orthologs for TES Gene

This gene was present in the common ancestor of animals.

Orthologs for TES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TES 34 33
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TES 34 33
  • 92.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TES 34 33
  • 91.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tes 33
  • 87.03 (n)
mouse
(Mus musculus)
Mammalia Tes 16 34 33
  • 86.79 (n)
Gm4907 34
  • 79 (a)
OneToMany
Gm4985 34
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TES 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TES 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TES 34 33
  • 79.76 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TES 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tes 33
  • 74.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia tes-prov 33
zebrafish
(Danio rerio)
Actinopterygii tes 34 33
  • 65.59 (n)
OneToOne
Dr.25730 33
fruit fly
(Drosophila melanogaster)
Insecta Tes 34 33
  • 51.38 (n)
OneToMany
CG6522 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea tes-1 34 33
  • 50.33 (n)
OneToMany
B0496.8 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for TES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TES Gene

ENSEMBL:
Gene Tree for TES (if available)
TreeFam:
Gene Tree for TES (if available)

Paralogs for TES Gene

Pseudogenes.org Pseudogenes for TES Gene

genes like me logo Genes that share paralogs with TES: view

Variants for TES Gene

Sequence variations from dbSNP and Humsavar for TES Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000083806 -- 116,259,246(+) TTCTC(C/T)CTCAG downstream-variant-500B
rs1000092571 -- 116,213,978(+) AATAT(C/T)TTTTT intron-variant
rs1000148851 -- 116,238,940(+) TAGGG(G/T)AGCTG intron-variant
rs1000178762 -- 116,238,644(+) TTGCC(C/T)AGGCT intron-variant
rs1000231006 -- 116,234,154(+) ATATG(A/T)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TES Gene

Variant ID Type Subtype PubMed ID
nsv949931 CNV duplication 24416366
nsv7405 OTHER inversion 18451855
nsv608240 CNV gain 21841781
esv3891195 CNV gain 25118596
esv3614690 CNV loss 21293372
esv3338084 CNV insertion 20981092
esv2735058 CNV deletion 23290073
esv2676666 CNV deletion 23128226

Variation tolerance for TES Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TES Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TES Gene

Disorders for TES Gene

MalaCards: The human disease database

(2) MalaCards diseases for TES Gene - From: DISEASES

Disorder Aliases PubMed IDs
louping ill
diphyllobothriasis
  • diphyllobothrium infection
- elite association - COSMIC cancer census association via MalaCards
Search TES in MalaCards View complete list of genes associated with diseases

Relevant External Links for TES

Genetic Association Database (GAD)
TES
Human Genome Epidemiology (HuGE) Navigator
TES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TES
genes like me logo Genes that share disorders with TES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TES Gene

Publications for TES Gene

  1. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. (PMID: 10950921) Tatarelli C … Croce CM (Genomics 2000) 2 3 4 22 60
  2. TES is a novel focal adhesion protein with a role in cell spreading. (PMID: 12571287) Coutts AS … Black DM (Journal of cell science 2003) 3 4 22 60
  3. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. (PMID: 21278383) Boëda B … Way M (The Journal of biological chemistry 2011) 3 4 60
  4. LIM domain protein TES changes its conformational states in different cellular compartments. (PMID: 18696217) Zhong Y … Zhang J (Molecular and cellular biochemistry 2009) 3 22 60
  5. Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. (PMID: 19289703) Gunduz E … Nagai N (Archives of otolaryngology--head & neck surgery 2009) 3 22 60

Products for TES Gene

Sources for TES Gene

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