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TES Gene

protein-coding   GIFtS: 61
GCID: GC07P115850

Testis Derived Transcript (3 LIM Domains)

  See TES-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Derived Transcript (3 LIM Domains)1 2
TESS2 3
TESS-22
testin2

External Ids:    HGNC: 146201   Entrez Gene: 261362   Ensembl: ENSG000001352697   OMIM: 6060855   UniProtKB: Q9UGI83   

Export aliases for TES gene to outside databases

Previous GC identifers: GC07P114328 GC07P115391 GC07P115405 GC07P115444 GC07P115637 GC07P110216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TES Gene:
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom
fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a
testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains
are double zinc-finger motifs that mediate protein-protein interactions between transcription factors,
cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as
a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the
reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this
gene.(provided by RefSeq, Mar 2011)

GeneCards Summary for TES Gene:
TES (testis derived transcript (3 LIM domains)) is a protein-coding gene. Diseases associated with TES include toxocariasis. An important paralog of this gene is PRICKLE3.

UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
Function: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the
actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits
tumor cell growth

Gene Wiki entry for TES (Testin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TES gene promoter:
         FOXI1   HFH-3   SRY   POU2F1   AP-1   Pbx1a   FOXO4   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TES promoter sequence
   Search Chromatin IP Primers for TES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31.2

TES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TES gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P115850:  view genomic region     (about GC identifiers)

Start:
115,850,547 bp from pter      End:
115,898,837 bp from pter
Size:
48,291 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,245,942-115,294,229     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8 (See protein sequence)
Recommended Name: Testin  
Size: 421 amino acids; 47996 Da
Subunit: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with
ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus).
Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer
2 PDB 3D structures from and Proteopedia for TES:
2IYB (3D)        2XQN (3D)    
Secondary accessions: A4D0U6 Q9GZQ1 Q9HAJ9
Alternative splicing: 2 isoforms:  Q9UGI8-1   Q9UGI8-2   

Explore the universe of human proteins at neXtProt for TES: NX_Q9UGI8

Explore proteomics data for TES at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71, Lys102
  • Modification sites at PhosphoSitePlus

  • See TES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056456.1  NP_690042.1  

    ENSEMBL proteins: 
     ENSP00000350937   ENSP00000413002   ENSP00000420220   ENSP00000377121   ENSP00000377124  
     ENSP00000441607  

    TES Human Recombinant Protein Products:

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    Novus Biologicals TES Proteins
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    Cloud-Clone Corp. Proteins for TES

     
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    Search eBioscience for ELISAs for TES 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010442 PET_domain
     IPR001781 Znf_LIM
     IPR027683 Testin

    Graphical View of Domain Structure for InterPro Entry Q9UGI8

    ProtoNet protein and cluster: Q9UGI8

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB010442 PET


    UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
    Domain: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering
    interactions with ZYX
    Similarity: Belongs to the prickle / espinas / testin family
    Similarity: Contains 3 LIM zinc-binding domains
    Similarity: Contains 1 PET domain


    Find genes that share domains with TES           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TES_HUMAN, Q9UGI8
    Function: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the
    actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits
    tumor cell growth

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IDA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TES           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tes):
     digestive/alimentary  normal  tumorigenesis 

    Find genes that share phenotypes with TES           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Testm1Cro for TES

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TES
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TES
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TES

    miRNA
    Products:
        
    miRTarBase miRNAs that target TES:
    hsa-let-7b-5p (MIRT032322), hsa-mir-186-5p (MIRT021189), hsa-mir-340-5p (MIRT019575), hsa-mir-98-5p (MIRT027620), hsa-mir-16-5p (MIRT051191), hsa-mir-130b-3p (MIRT020280), hsa-mir-34a-5p (MIRT025480), hsa-mir-19b-3p (MIRT031121)

    Block miRNA regulation of human, mouse, rat TES using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TES (see all 20):
    hsa-miR-520d-5p hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-9 hsa-miR-130b hsa-miR-3163 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidTES 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TES
    Predesigned siRNA for gene silencing in human, mouse, rat TES

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TES (see all 12)
    OriGene ORF clones in mouse, rat for TES
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    GenScript: all cDNA clones in your preferred vector: TES (NM_006285)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TES

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TES


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TES_HUMAN, Q9UGI8: Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0005925focal adhesion IEA--
    GO:0030054cell junction ----
    GO:0043234protein complex IDA--

    Find genes that share ontologies with TES           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TES
    Interactions:

        GeneGlobe Interaction Network for TES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TES (Q9UGI82, 3 ENSP000003509374) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENAHQ8N8S73, ENSP000003558094I2D: score=3 STRING: ENSP00000355809
    TLN1Q9Y4903, ENSP000003160294I2D: score=3 STRING: ENSP00000316029
    ZYXQ159423, ENSP000003244224I2D: score=3 STRING: ENSP00000324422
    EVLQ9UI083, ENSP000003766524I2D: score=2 STRING: ENSP00000376652
    SPOCK2Q925633, ENSP000003211084I2D: score=2 STRING: ENSP00000321108
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IMP11420696
    GO:0042127regulation of cell proliferation ----

    Find genes that share ontologies with TES           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TES



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TES gene (2 alternative transcripts): 
    NM_015641.3  NM_152829.2  

    Unigene Clusters for TES:

    Testis derived transcript (3 LIM domains)
    Hs.592286  [show with all ESTs], Hs.664957  [show with all ESTs]
    Unigene Representative Sequences: NM_015641, BC040208
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358204(uc003vho.3 uc011kmy.2) ENST00000461440 ENST00000455989
    ENST00000492891 ENST00000496871 ENST00000393481(uc003vhp.3 uc022aki.1)
    ENST00000485009(uc011kmx.2 uc010lka.2) ENST00000393484 ENST00000494384
    ENST00000496912 ENST00000463746 ENST00000537767
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TES using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TES (see all 20):
    hsa-miR-520d-5p hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-9 hsa-miR-130b hsa-miR-3163 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidTES 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TES
    Predesigned siRNA for gene silencing in human, mouse, rat TES
    Clone
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    OriGene clones in human, mouse for TES (see all 12)
    OriGene ORF clones in mouse, rat for TES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TES (NM_006285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TES
    Primer
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    OriGene qPCR primer pairs and template standards for TES
    OriGene qSTAR qPCR primer pairs in human, mouse for TES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TES
      QuantiTect SYBR Green Assays in human, mouse, rat TES
      QuantiFast Probe-based Assays in human, mouse, rat TES

    Additional mRNA sequence: 

    BC038749.1 BC040208.1 BC045580.1 

    17 DOTS entries:

    DT.99985992  DT.100791217  DT.213628  DT.40212827  DT.97785288  DT.99956830  DT.92439649  DT.95240028 
    DT.91736399  DT.95240026  DT.95240027  DT.101970191  DT.91735206  DT.91984336  DT.100026235  DT.121056309 
    DT.455952 

    16 AceView cDNA sequences:

    BC038749 BC040208 BC045580 AW205261 AA719392 AI807692 BE217721 AW873515 
    AW628631 BI461537 BG719796 BF059668 BG772994 BX398124 BF477884 AA897447 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TES    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                      -                 -                     
    SP2:                    -                 -                 -                     
    SP3:                    -     -           -                                       
    SP4:                    -     -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for TES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTAGAAG
    TES Expression
    About this image


    TES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Stylopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
             Extraembryonic Visceral Endoderm
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Ectoderm Cells Extraembryonic Ectoderm
             Extraembryonic Ectoderm
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
    TES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TES Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.592286 Hs.664957

    UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat TES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TES gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tes1 , 5 testis derived transcript1, 5 86.79(n)1
    92.6(a)1
      6 (7.67 cM)5
    217531  NM_207176.31  NP_997059.11 
     170651495 
    chicken
    (Gallus gallus)
    Aves TES1 testis derived transcript (3 LIM domains) 79.76(n)
    89.05(a)
      395332  NM_204623.1  NP_989954.1 
    lizard
    (Anolis carolinensis)
    Reptilia TES6
    testis derived transcript (3 LIM domains)
    86(a)
    1 ↔ 1
    5(60741318-60793674)
    African clawed frog
    (Xenopus laevis)
    Amphibia tes-prov2 testis derived transcript (3 LIM domains) 77.55(n)    BC045027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257302 Danio rerio testis derived transcript (TES) mRNA, complete more 74.65(n)    AY391465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65223
    Tes1
    Testin ortholog1 36(a)3
    51.38(n)1
    42.27(a)1
      54B163
    369651  NM_137371.31  NP_611215.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0496.83
    tes-11
    LIM-domain protein3
    tes-11
    35(a)3
    50.33(n)1
    40(a)1
      IV(7449530-7451631)3
    1775151  NM_068789.41  NP_501190.11 


    ENSEMBL Gene Tree for TES (if available)
    TreeFam Gene Tree for TES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TES gene
    PRICKLE32  PRICKLE42  LMCD12  PRICKLE22  PRICKLE12  
    9 SIMAP similar genes for TES using alignment to 7 protein entries:     TES_HUMAN (see all proteins):
    DKFZp586B2022    LMCD1    PRICKLE4    LHX8    PRICKLE2    PRICKLE3
    PRICKLE1    RILP    LMO6

    Find genes that share paralogs with TES           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TES
    PGOHUM00000234943


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TES (see all 1135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472411261,2
    C--115848627(+) TATTT-/TCTC  
            
    TCTTT
    1 -- us2k10--------
    rs1508812961,2
    --115848878(+) TGATAA/GTTCCA 1 -- us2k10--------
    rs38080021,2
    C--115848954(+) GAGGGC/TTGGGA 1 -- us2k10--------
    rs114052321,2
    C--115848993(+) AAAAA-/AGTTTC 1 -- us2k1 trp30--------
    rs770255151,2
    --115848993(+) ACAGTA/TAAAAA 1 -- us2k10--------
    rs732205001,2
    C,F--115849017(+) GATGGT/ATTTCT 1 -- us2k14Minor allele frequency- A:0.12NA WA EA 360
    rs1428767081,2
    --115849073(+) GTTACA/GACATT 1 -- us2k10--------
    rs754808321,2
    F--115849204(+) ACTTTG/ACAGGG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1172629071,2
    F--115849373(+) ATCAAG/CTAAGC 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1817810341,2
    C--115849395(+) TATTGA/GCTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TES (115850547 - 115898837 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TES:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735058CNV Deletion23290073
    esv2676666CNV Deletion23128226
    esv267809CNV Insertion20981092
    esv274354CNV Insertion20981092
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TES
    DNA2.0 Custom Variant and Variant Library Synthesis for TES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606085    OMIM disorders: --

    1 disease for TES:    
    About MalaCards
    toxocariasis

    2 diseases from the University of Copenhagen DISEASES database for TES:
    Toxocariasis     Syphilis

    Find genes that share disorders with TES           About GenesLikeMe

    3 Novoseek inferred disease relationships for TES gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 42.5 5 18799041 (4), 12620387 (1)
    tumors 22.8 21 15701871 (4), 19289703 (2), 16033868 (2), 12620387 (2) (see all 7)
    cancer 6.42 8 19289703 (3), 15701871 (1)

    Genetic Association Database (GAD): TES
    Human Genome Epidemiology (HuGE) Navigator: TES (164 documents)

    Export disorders for TES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TES gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with TES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. (PubMed id 10950921)1, 2, 3, 9 Tatarelli C.... Croce C.M. (Genomics 2000)
    2. TES is a novel focal adhesion protein with a role in cell spreading. (PubMed id 12571287)1, 2, 9 Coutts A.S.... Black D.M. (J. Cell Sci. 2003)
    3. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. (PubMed id 21278383)1, 2 Boeda B.... Way M. (J. Biol. Chem. 2011)
    4. Association of testis derived transcript gene variants and prostate cancer risk. (PubMed id 17296370)1, 4 Liu X....Witte J.S. (J. Urol. 2007)
    5. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. (PubMed id 18158903)1, 2 Boeda B.... Way M. (Mol. Cell 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PubMed id 12695497)1, 2 Garvalov B.K.... Way M. (J. Cell Biol. 2003)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26136 HGNC: 14620 AceView: TES.1 Ensembl:ENSG00000135269 euGenes: HUgn26136
    ECgene: TES H-InvDB: TES

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TES Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TES Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TES gene:
    Search GeneIP for patents involving TES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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