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Aliases for TES Gene

Aliases for TES Gene

  • Testin LIM Domain Protein 2 3 5
  • Testis Derived Transcript (3 LIM Domains) 2 3
  • TESS 3 4
  • TESS-2 3

External Ids for TES Gene

Previous GeneCards Identifiers for TES Gene

  • GC07P114328
  • GC07P115391
  • GC07P115405
  • GC07P115444
  • GC07P115637
  • GC07P115850
  • GC07P110216

Summaries for TES Gene

Entrez Gene Summary for TES Gene

  • Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for TES Gene

TES (Testin LIM Domain Protein) is a Protein Coding gene. Diseases associated with TES include Louping Ill and Diphyllobothriasis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PRICKLE2.

UniProtKB/Swiss-Prot for TES Gene

  • Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Gene Wiki entry for TES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TES Gene

Genomics for TES Gene

Regulatory Elements for TES Gene

Enhancers for TES Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TES on UCSC Golden Path with GeneCards custom track

Promoters for TES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TES on UCSC Golden Path with GeneCards custom track

Genomic Location for TES Gene

Chromosome:
7
Start:
116,210,493 bp from pter
End:
116,258,786 bp from pter
Size:
48,294 bases
Orientation:
Plus strand

Genomic View for TES Gene

Genes around TES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TES Gene

Proteins for TES Gene

  • Protein details for TES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGI8-TES_HUMAN
    Recommended name:
    Testin
    Protein Accession:
    Q9UGI8
    Secondary Accessions:
    • A4D0U6
    • Q9GZQ1
    • Q9HAJ9

    Protein attributes for TES Gene

    Size:
    421 amino acids
    Molecular mass:
    47996 Da
    Quaternary structure:
    • Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.

    Three dimensional structures from OCA and Proteopedia for TES Gene

    Alternative splice isoforms for TES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TES Gene

Proteomics data for TES Gene at MOPED

Post-translational modifications for TES Gene

  • Ubiquitination at Lys 71 and Lys 102
  • Modification sites at PhosphoSitePlus

Other Protein References for TES Gene

No data available for DME Specific Peptides for TES Gene

Domains & Families for TES Gene

Gene Families for TES Gene

Protein Domains for TES Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGI8

UniProtKB/Swiss-Prot:

TES_HUMAN :
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
  • Contains 3 LIM zinc-binding domains.
  • Contains 1 PET domain.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with TES: view

Function for TES Gene

Molecular function for TES Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Gene Ontology (GO) - Molecular Function for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21278383
genes like me logo Genes that share ontologies with TES: view

Phenotypes for TES Gene

MGI mutant phenotypes for TES:
inferred from 2 alleles
GenomeRNAi human phenotypes for TES:
genes like me logo Genes that share phenotypes with TES: view

Animal Models for TES Gene

MGI Knock Outs for TES:

Animal Model Products

miRNA for TES Gene

miRTarBase miRNAs that target TES

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TES Gene

Localization for TES Gene

Subcellular locations from UniProtKB/Swiss-Prot for TES Gene

Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TES Gene COMPARTMENTS Subcellular localization image for TES gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TES: view

Pathways & Interactions for TES Gene

SuperPathways for TES Gene

No Data Available

Gene Ontology (GO) - Biological Process for TES Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TES Gene

Drugs & Compounds for TES Gene

(5) Drugs for TES Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator 2080
Triamcinolone Approved Pharma Agonist 455
triamcinolone acetonide Pharma Agonist 455
Triamcinolone diacetate Pharma 455
Triamcinolone hexacetonide Pharma 455
genes like me logo Genes that share compounds with TES: view

Transcripts for TES Gene

mRNA/cDNA for TES Gene

Unigene Clusters for TES Gene

Testis derived transcript (3 LIM domains):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TES Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for TES Gene

GeneLoc Exon Structure for
TES
ECgene alternative splicing isoforms for
TES

Expression for TES Gene

mRNA expression in normal human tissues for TES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TES Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for TES Gene

This gene is overexpressed in Rectum (9.9), Colon (8.9), and Uterus (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TES Gene



SOURCE GeneReport for Unigene cluster for TES Gene Hs.592286

mRNA Expression by UniProt/SwissProt for TES Gene

Q9UGI8-TES_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TES: view

Protein tissue co-expression partners for TES Gene

- Elite partner

Orthologs for TES Gene

This gene was present in the common ancestor of animals.

Orthologs for TES Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TES 35
  • 91.45 (n)
  • 96.2 (a)
TES 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TES 35
  • 92.79 (n)
  • 96.67 (a)
TES 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tes 35
  • 86.79 (n)
  • 92.6 (a)
Tes 16
Gm4907 36
  • 79 (a)
OneToMany
Gm4985 36
  • 78 (a)
OneToMany
Tes 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TES 35
  • 99.92 (n)
  • 100 (a)
TES 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tes 35
  • 87.03 (n)
  • 93.56 (a)
oppossum
(Monodelphis domestica)
Mammalia TES 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TES 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TES 35
  • 79.76 (n)
  • 89.05 (a)
TES 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TES 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tes 35
  • 74.9 (n)
  • 81.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia tes-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25730 35
tes 35
  • 65.59 (n)
  • 62.28 (a)
tes 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6522 37
  • 36 (a)
Tes 35
  • 51.38 (n)
  • 42.27 (a)
Tes 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0496.8 37
  • 35 (a)
tes-1 35
  • 50.33 (n)
  • 40 (a)
tes-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TES Gene

ENSEMBL:
Gene Tree for TES (if available)
TreeFam:
Gene Tree for TES (if available)

Paralogs for TES Gene

Paralogs for TES Gene

Pseudogenes.org Pseudogenes for TES Gene

genes like me logo Genes that share paralogs with TES: view

Variants for TES Gene

Sequence variations from dbSNP and Humsavar for TES Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2272193 - 116,250,456(-) CCATG(A/G)CCCCC reference, missense
rs950525 -- 116,224,469(+) TAGTC(A/G)TGTCT intron-variant
rs1000765 -- 116,224,412(-) TGCAG(C/T)ACTCA intron-variant
rs1000966 -- 116,222,848(+) CCATT(A/G)CAGTG intron-variant, upstream-variant-2KB
rs1000967 -- 116,223,260(+) AGTAC(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TES Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
esv2676666 CNV Deletion 23128226
esv2735058 CNV Deletion 23290073
esv274354 CNV Insertion 20981092
esv267809 CNV Insertion 20981092

Variation tolerance for TES Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TES Gene

Disorders for TES Gene

MalaCards: The human disease database

(4) MalaCards diseases for TES Gene - From: DISEASES

Disorder Aliases PubMed IDs
louping ill
diphyllobothriasis
  • diphyllobothrium infection
sarcomatosis
  • sarcomatosis nos
dysgraphia
  • agraphia
- elite association - COSMIC cancer census association via MalaCards
Search TES in MalaCards View complete list of genes associated with diseases

Relevant External Links for TES

Genetic Association Database (GAD)
TES
Human Genome Epidemiology (HuGE) Navigator
TES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TES
genes like me logo Genes that share disorders with TES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TES Gene

Publications for TES Gene

  1. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. (PMID: 10950921) Tatarelli C. … Croce C.M. (Genomics 2000) 2 3 4 23 67
  2. LIM domain protein TES changes its conformational states in different cellular compartments. (PMID: 18696217) Zhong Y. … Zhang J. (Mol. Cell. Biochem. 2009) 3 23
  3. Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. (PMID: 19289703) Gunduz E. … Nagai N. (Arch. Otolaryngol. Head Neck Surg. 2009) 3 23
  4. [Expression and clinical significance of TESTIN in primary gastric cancer]. (PMID: 18799041) Huang W. … Xia J.C. (Ai Zheng 2008) 3 23
  5. TES is a novel focal adhesion protein with a role in cell spreading. (PMID: 12571287) Coutts A.S. … Black D.M. (J. Cell Sci. 2003) 3 23

Products for TES Gene

Sources for TES Gene

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