Aliases for TES Gene
External Ids for TES Gene
Previous GeneCards Identifiers for TES Gene
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for TES Gene
TES (Testin LIM Domain Protein) is a Protein Coding gene. Diseases associated with TES include louping ill and diphyllobothriasis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PRICKLE2.
UniProtKB/Swiss-Prot for TES Gene
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.