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Aliases for TES Gene

Aliases for TES Gene

  • Testin LIM Domain Protein 2 3 5
  • Testis Derived Transcript (3 LIM Domains) 2 3
  • TESS 3 4
  • TESS-2 3
  • Testin 3

External Ids for TES Gene

Previous GeneCards Identifiers for TES Gene

  • GC07P114328
  • GC07P115391
  • GC07P115405
  • GC07P115444
  • GC07P115637
  • GC07P115850
  • GC07P110216

Summaries for TES Gene

Entrez Gene Summary for TES Gene

  • Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for TES Gene

TES (Testin LIM Domain Protein) is a Protein Coding gene. Diseases associated with TES include Louping Ill and Diphyllobothriasis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LMCD1.

UniProtKB/Swiss-Prot for TES Gene

  • Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Gene Wiki entry for TES Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TES Gene

Genomics for TES Gene

Regulatory Elements for TES Gene

Enhancers for TES Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G116209 1.7 Ensembl ENCODE dbSUPER 19.8 +4.3 4268 10.0 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC ST7-AS1 TES TFEC LOC102724434 ENSG00000279086 GC07P116253
GH07G116165 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -44.4 -44400 1.4 PKNOX1 FEZF1 ZSCAN5C RELB IKZF2 CREM OVOL3 JUNB ZEB2 TBX21 TES TFEC
GH07G116180 0.9 Ensembl ENCODE 18.7 -30.0 -30030 0.3 CTCF ZNF654 TRIM22 REST ZNF2 RAD21 RFX5 FOXK2 SMC3 ZNF143 TES TFEC ENSG00000235427
GH07G116173 1.1 Ensembl ENCODE dbSUPER 11.9 -37.3 -37293 0.4 ZNF263 CTCF ZNF654 REST RAD21 POLR2H SMC3 EZH2 TES TFEC
GH07G116226 1.4 Ensembl ENCODE dbSUPER 9.3 +19.5 19484 7.2 PKNOX1 KLF17 FEZF1 ZNF366 FOS ZNF362 ZEB2 SMARCB1 ZNF592 MAFF TFEC ENSG00000235427 TES LOC102724434 ENSG00000279086 GC07P116253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TES on UCSC Golden Path with GeneCards custom track

Promoters for TES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217069 907 2401 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TES Gene

Chromosome:
7
Start:
116,210,493 bp from pter
End:
116,258,786 bp from pter
Size:
48,294 bases
Orientation:
Plus strand

Genomic View for TES Gene

Genes around TES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TES Gene

Proteins for TES Gene

  • Protein details for TES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGI8-TES_HUMAN
    Recommended name:
    Testin
    Protein Accession:
    Q9UGI8
    Secondary Accessions:
    • A4D0U6
    • Q9GZQ1
    • Q9HAJ9

    Protein attributes for TES Gene

    Size:
    421 amino acids
    Molecular mass:
    47996 Da
    Quaternary structure:
    • Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.

    Three dimensional structures from OCA and Proteopedia for TES Gene

    Alternative splice isoforms for TES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TES Gene

Post-translational modifications for TES Gene

  • Ubiquitination at isoforms=271 and posLast=102102
  • Modification sites at PhosphoSitePlus

Other Protein References for TES Gene

No data available for DME Specific Peptides for TES Gene

Domains & Families for TES Gene

Gene Families for TES Gene

Protein Domains for TES Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGI8

UniProtKB/Swiss-Prot:

TES_HUMAN :
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with TES: view

Function for TES Gene

Molecular function for TES Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Gene Ontology (GO) - Molecular Function for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21278383
GO:0008270 zinc ion binding IEA,IDA 21278383
GO:0045296 cadherin binding IDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TES: view

Phenotypes for TES Gene

MGI mutant phenotypes for TES:
inferred from 2 alleles
GenomeRNAi human phenotypes for TES:
genes like me logo Genes that share phenotypes with TES: view

Animal Models for TES Gene

MGI Knock Outs for TES:

Animal Model Products

CRISPR Products

miRNA for TES Gene

miRTarBase miRNAs that target TES

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TES

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TES Gene

Localization for TES Gene

Subcellular locations from UniProtKB/Swiss-Prot for TES Gene

Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TES gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA,IEA 21423176
genes like me logo Genes that share ontologies with TES: view

Pathways & Interactions for TES Gene

No Data Available

Gene Ontology (GO) - Biological Process for TES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IMP 11420696
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TES: view

No data available for Pathways by source and SIGNOR curated interactions for TES Gene

Drugs & Compounds for TES Gene

(5) Drugs for TES Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator 2606
Triamcinolone Approved, Vet_approved Pharma Agonist 510
triamcinolone acetonide Pharma Agonist 510
Triamcinolone diacetate Pharma 510
Triamcinolone hexacetonide Pharma 510
genes like me logo Genes that share compounds with TES: view

Transcripts for TES Gene

Unigene Clusters for TES Gene

Testis derived transcript (3 LIM domains):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TES

Alternative Splicing Database (ASD) splice patterns (SP) for TES Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for TES Gene

GeneLoc Exon Structure for
TES
ECgene alternative splicing isoforms for
TES

Expression for TES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TES Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for TES Gene

This gene is overexpressed in Rectum (9.9), Colon (8.9), and Uterus (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TES Gene



Protein tissue co-expression partners for TES Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TES Gene:

TES

SOURCE GeneReport for Unigene cluster for TES Gene:

Hs.592286

mRNA Expression by UniProt/SwissProt for TES Gene:

Q9UGI8-TES_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TES Gene

  • Skin(2.9)
  • Heart(2.8)
  • Intestine(2.6)
  • Thyroid gland(2.5)
  • Blood(2.4)
  • Nervous system(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TES: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TES Gene

Orthologs for TES Gene

This gene was present in the common ancestor of animals.

Orthologs for TES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TES 34 35
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia TES 34 35
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia TES 34 35
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Tes 34
  • 87.03 (n)
mouse
(Mus musculus)
Mammalia Tes 34 16 35
  • 86.79 (n)
Gm4907 35
  • 79 (a)
OneToMany
Gm4985 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TES 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TES 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TES 34 35
  • 79.76 (n)
lizard
(Anolis carolinensis)
Reptilia TES 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tes 34
  • 74.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia tes-prov 34
zebrafish
(Danio rerio)
Actinopterygii tes 34 35
  • 65.59 (n)
Dr.25730 34
fruit fly
(Drosophila melanogaster)
Insecta Tes 34 35
  • 51.38 (n)
CG6522 36
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea tes-1 34 35
  • 50.33 (n)
B0496.8 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for TES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TES Gene

ENSEMBL:
Gene Tree for TES (if available)
TreeFam:
Gene Tree for TES (if available)

Paralogs for TES Gene

Pseudogenes.org Pseudogenes for TES Gene

genes like me logo Genes that share paralogs with TES: view

Variants for TES Gene

Sequence variations from dbSNP and Humsavar for TES Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000083806 -- 116,259,246(+) TTCTC(C/T)CTCAG downstream-variant-500B
rs1000092571 -- 116,213,978(+) AATAT(C/T)TTTTT intron-variant
rs1000148851 -- 116,238,940(+) TAGGG(G/T)AGCTG intron-variant
rs1000178762 -- 116,238,644(+) TTGCC(C/T)AGGCT intron-variant
rs1000231006 -- 116,234,154(+) ATATG(A/T)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TES Gene

Variant ID Type Subtype PubMed ID
esv2676666 CNV deletion 23128226
esv2735058 CNV deletion 23290073
esv3338084 CNV insertion 20981092
esv3614690 CNV loss 21293372
esv3891195 CNV gain 25118596
nsv608240 CNV gain 21841781
nsv7405 OTHER inversion 18451855
nsv949931 CNV duplication 24416366

Variation tolerance for TES Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TES Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TES Gene

Disorders for TES Gene

MalaCards: The human disease database

(3) MalaCards diseases for TES Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
louping ill
diphyllobothriasis
  • diphyllobothrium infection
dysgraphia
  • agraphia
- elite association - COSMIC cancer census association via MalaCards
Search TES in MalaCards View complete list of genes associated with diseases

Relevant External Links for TES

Genetic Association Database (GAD)
TES
Human Genome Epidemiology (HuGE) Navigator
TES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TES
genes like me logo Genes that share disorders with TES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TES Gene

Publications for TES Gene

  1. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. (PMID: 10950921) Tatarelli C. … Croce C.M. (Genomics 2000) 2 3 4 22 64
  2. TES is a novel focal adhesion protein with a role in cell spreading. (PMID: 12571287) Coutts A.S. … Black D.M. (J. Cell Sci. 2003) 3 4 22 64
  3. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. (PMID: 21278383) Boeda B. … Way M. (J. Biol. Chem. 2011) 3 4 64
  4. LIM domain protein TES changes its conformational states in different cellular compartments. (PMID: 18696217) Zhong Y. … Zhang J. (Mol. Cell. Biochem. 2009) 3 22 64
  5. Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. (PMID: 19289703) Gunduz E. … Nagai N. (Arch. Otolaryngol. Head Neck Surg. 2009) 3 22 64

Products for TES Gene

  • Addgene plasmids for TES

Sources for TES Gene

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