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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TES Gene

protein-coding   GIFtS: 57
GCID: GC07P115850

testis derived transcript (3 LIM domains)
 Explore 11 diseases affiliated with
TES via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TES    

Aliases
for TES gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Testis Derived Transcript (3 LIM Domains)1 2
TESS-21 2
TESS2 3
DKFZP586B20221
TESTIN1
Testin1

External Ids:    HGNC: 146201   Entrez Gene: 261362   Ensembl: ENSG000001352697   OMIM: 6060855   UniProtKB: Q9UGI83   

Export aliases for TES gene to outside databases

Previous GC identifers: GC07P114328 GC07P115391 GC07P115405 GC07P115444 GC07P115637 GC07P110216


Summaries
for TES gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TES:
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom
fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive
gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs
that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins.
This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also
play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein
isoforms are encoded by transcript variants of this gene.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
Function: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin
cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell
growth

Gene Wiki entry for TES (Testin)


Genomic Views
for TES gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TES gene promoter:
         FOXI1   HFH-3   SRY   POU2F1   AP-1   Pbx1a   FOXO4   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TES promoter sequence
   Search SABiosciences Chromatin IP Primers for TES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31.2

TES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TES gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P115850:  view genomic region     (about GC identifiers)

Start:
 115,850,547 bp from pter      End:
 115,898,837 bp from pter
Size:
 48,291 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,245,976-115,294,229     

Proteins
for TES gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8 (See protein sequence)
Recommended Name: Testin  
Size: 421 amino acids; 47996 Da
Subunit: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with talin,
actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with
ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer
Subcellular location: Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers
2 PDB 3D structures from and Proteopedia for TES:
2IYB (3D)        2XQN (3D)    
Secondary accessions: A4D0U6 Q9GZQ1 Q9HAJ9
Alternative splicing: 2 isoforms:  Q9UGI8-1   Q9UGI8-2   

Explore the universe of human proteins at neXtProt for TES: NX_Q9UGI8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UGI8

    • TES Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_056456.1  NP_690042.1  

    ENSEMBL proteins: 
     ENSP00000350937   ENSP00000413002   ENSP00000420220   ENSP00000377121   ENSP00000377124  
     ENSP00000441607  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: TES
    OriGene Protein Over-expression Lysate: TES
    OriGene Custom Protein Services for TES 
    GenScript Custom Purified and Recombinant Proteins Services for TES
    Novus Biologicals TES Proteins
    Novus Biologicals TES Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TES
    Uscn Proteins for TES

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0005925focal adhesion IEA--
    GO:0030054cell junction IDA--


    TES for ontologies           About GeneDecksing



    TES Antibody Products: 
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    Search for Antibodies for TES at Abcam  
    Uscn Antibodies for TES
    ThermoFisher Antibodies for TES

    Assay Products for TES: 
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    Uscn ELISAs and CLIAs for TES

    Protein Domains /
    Families
    for TES gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TES for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR010442 PET_domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q9UGI8

    ProtoNet protein and cluster: Q9UGI8

    2 Blocks protein families:
    IPB001781 Zn-binding protein
    IPB010442 PET


    UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
    Domain: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering
    interactions with ZYX
    Similarity: Belongs to the prickle / espinas / testin family
    Similarity: Contains 3 LIM zinc-binding domains
    Similarity: Contains 1 PET domain


    Function
    for TES gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
    Function: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin
    cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell
    growth

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): TES
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TES
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TES (see all 20):
    hsa-miR-520d-5p hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-9 hsa-miR-130b hsa-miR-3163 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: TES 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TES (see all 7)
    OriGene shRNA RFP: TES
    OriGene siRNA: TES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TES

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TES

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TES (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TES (NM_006285)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TES 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TES
    Search LifeMap BioReagents cell lines for TES

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TES

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IDA--


    TES for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Testm1Cro for TES
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tes):
     digestive/alimentary  normal  tumorigenesis 

    TES for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TES gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/22 Interacting proteins for TES (Q9UGI82, 3 ENSP000003509374) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENAHQ8N8S73, ENSP000003558094I2D: score=3 STRING: ENSP00000355809
    TLN1Q9Y4903, ENSP000003160294I2D: score=3 STRING: ENSP00000316029
    ZYXQ159423, ENSP000003244224I2D: score=3 STRING: ENSP00000324422
    EVLQ9UI083, ENSP000003766524I2D: score=2 STRING: ENSP00000376652
    SPOCK2Q925633, ENSP000003211084I2D: score=2 STRING: ENSP00000321108
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IMP11420696


    TES for ontologies           About GeneDecksing



    Drugs & Compounds
    for TES gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TES
    Search CenterWatch for drugs/clinical trials and news about TES 

    Transcripts
    for TES gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TES gene (2 alternative transcripts): 
    NM_015641.3  NM_152829.2  

    Unigene Clusters for TES:

    Testis derived transcript (3 LIM domains)
    Hs.592286  [show with all ESTs], Hs.664957  [show with all ESTs]
    Unigene Representative Sequences: NM_015641, BC040208
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358204(uc003vho.3 uc011kmy.2) ENST00000461440 ENST00000455989
    ENST00000492891 ENST00000496871 ENST00000393481(uc003vhp.3 uc022aki.1)
    ENST00000485009(uc011kmx.2 uc010lka.2) ENST00000393484 ENST00000494384
    ENST00000496912 ENST00000463746 ENST00000537767

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TES
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TES
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TES (see all 20):
    hsa-miR-520d-5p hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-9 hsa-miR-130b hsa-miR-3163 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: TES 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TES (see all 7)
    OriGene shRNA RFP: TES
    OriGene siRNA: TES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TES
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TES (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TES (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TES (NM_006285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TES 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TES
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TES
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TES
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TES

    Additional cDNA sequence: 

    BC038749.1 BC040208.1 BC045580.1 

    17 DOTS entries:

    DT.99985992  DT.100791217  DT.213628  DT.40212827  DT.97785288  DT.99956830  DT.92439649  DT.95240028 
    DT.91736399  DT.95240026  DT.95240027  DT.101970191  DT.91735206  DT.91984336  DT.100026235  DT.121056309 
    DT.455952 

    16 AceView cDNA sequences:

    BC040208 BC038749 BC045580 AW873515 BE217721 AW628631 AI807692 AW205261 
    AA719392 BG719796 BI461537 BF059668 AA897447 BG772994 BX398124 BF477884 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TES    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                      -                 -                     
    SP2:                    -                 -                 -                     
    SP3:                    -     -           -                                       
    SP4:                    -     -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for TES

    Expression
    for TES gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGTAGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TES expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneStylopod Long BoneBone
    EyeRetinaEye
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    KidneyInterstitial StromaKidney
    KidneyMetanephrosKidney
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See TES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TES

    SOURCE GeneReport for Unigene clusters: Hs.592286 Hs.664957

    UniProtKB/Swiss-Prot: TES_HUMAN, Q9UGI8
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for TES
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TES
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TES
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TES

    Orthologs
    for TES gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TES gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TES1 testis derived transcript (3 LIM domains) 79.76(n)
    89.05(a)    		   395332  NM_204623.1  NP_989954.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPB496
    TES6
    		 --
    85(a)
    		 possible ortholog
    1 ↔ 1
    		 GL343858.1(9805-19722)
    5(60762194-60789869)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tes-prov2 testis derived transcript (3 LIM domains) 77.55(n)    BC045027.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.257302 Danio rerio testis derived transcript (TES) mRNA, complete more 74.65(n)    AY391465.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG65223   -- 36(a)   54B16   --
    worm
    (Caenorhabditis elegans)    		 Secernentea B0496.83
    tes-11    		 LIM-domain protein3
    Protein TES-11    		 35(a)3
    50.42(n)1
    40(a)1    		   IV(7449530-7451631)3
    1775151  NM_068789.31  NP_501190.11 


    ENSEMBL Gene Tree for TES (if available)
    TreeFam Gene Tree for TES (if available) 

    Paralogs
    for TES gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TES gene
    PRICKLE32  PRICKLE42  LMCD12  PRICKLE22  PRICKLE12  
    9 SIMAP similar genes for TES using alignment to 7 protein entries:     TES_HUMAN (see all proteins):
    DKFZp586B2022    LMCD1    PRICKLE4    LHX8    PRICKLE2    PRICKLE3
    PRICKLE1    RILP    LMO6

    TES for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TES
    PGOHUM00000234943


    Genomic Variants
    for TES gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/931 NCBI SNPs in TES are shown (see all 931)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1472411261,2
    		--115848627(+) TATTT-/TCTC  
                TCTTT     		1 -- us2k10--------
    rs1508812961,2
    		--115848878(+) TGATAA/GTTCCA 1 -- us2k10--------
    rs38080021,2
    		C,--115848954(+) GAGGGC/TTGGGA 1 -- us2k10--------
    rs114052321,2
    		C,--115848993(+) CAGTT-/AAAAAA 1 -- us2k1 trp30--------
    rs770255151,2
    		--115848993(+) ACAGTA/TAAAAA 1 -- us2k10--------
    rs339738701,2
    		C--115848994(+) AAAAA-/AGTTTC 1 -- us2k10--------
    rs732205001,2
    		C,--115849017(+) GATGGT/ATTTCT 1 -- us2k14Minor allele frequency- A:0.12NA WA EA 360
    rs1428767081,2
    		--115849073(+) GTTACA/GACATT 1 -- us2k10--------
    rs754808321,2
    		--115849204(+) ACTTTG/ACAGGG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1172629071,2
    		F,--115849373(+) ATCAAG/CTAAGC 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for TES (115850547 - 115898837 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TES
         2 CNVs: 94827 94826

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TES
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    Disorders / Diseases
    for TES gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TES for disorders           About GeneDecksing

    OMIM gene information: 606085    OMIM disorders: --

    11 diseases for TES:    About MalaCards
    toxocariasis    clonorchiasis    pneumothorax    squamous cell carcinoma
    gastric cancer    ovarian cancer    prostate cancer    glioblastoma
    prostatitis    immunodeficiency    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for TES:
    Toxocariasis     Syphilis

    3 Novoseek disease relationships for TES gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 42.5 5 18799041 (4), 12620387 (1)
    tumors 22.8 21 15701871 (4), 19289703 (2), 16033868 (2), 12620387 (2) (see all 7)
    cancer 6.42 8 19289703 (3), 15701871 (1)

    Human Genome Epidemiology (HuGE) Navigator: TES (164 documents)

    Export disorders for TES gene to outside databases

    Publications
    for TES gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TES gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with TES)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. (PubMed id 10950921)1, 2, 3, 9 Tatarelli C.... Croce C.M. (2000)
    2. TES is a novel focal adhesion protein with a role in cell spreading. (PubMed id 12571287)1, 2, 9 Coutts A.S....Black D.M. (2003)
    3. Molecular recognition of the Tes LIM2-3 domains by th e actin-related protein Arp7A. (PubMed id 21278383)1, 2 BoAda B....Way M. (2011)
    4. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. (PubMed id 18158903)1, 2 Boeda B....Way M. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PubMed id 12695497)1, 2 Garvalov B.K.... Way M. (2003)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. (PubMed id 11420696)1, 2 Tobias E.S.... Black D.M. (2001)

    External Searches for TES gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TES gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26136 HGNC: 14620 AceView: TES.1 Ensembl:ENSG00000135269 euGenes: HUgn26136
    ECgene: TES H-InvDB: TES

    Other Databases showing TES gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TES gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TES Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TES Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TES gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TES gene:
    Search GeneIP for patents involving TES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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