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protein-coding   GIFtS: 73
GCID: GC05M001253

Telomerase Reverse Transcriptase

  See TERT-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Telomerase Reverse Transcriptase1 2     CMM92 5
EST22 3 5     DKCA22 5
TCS12 3 5     DKCB42 5
Telomerase Catalytic Subunit2 3     PFBMFT12 5
Telomerase-Associated Protein 22 3     hEST22
TP22 3     hTRT2
TRT2 3     HEST23
EC 8     EC 2.7.78

External Ids:    HGNC: 117301   Entrez Gene: 70152   Ensembl: ENSG000001643627   OMIM: 1872705   UniProtKB: O147463   

Export aliases for TERT gene to outside databases

Previous GC identifiers: GC05P001643 GC05M001282 GC05M001306

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TERT Gene:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat
TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and
an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in
cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening
of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in
mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere
repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of
telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been
determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase
activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for TERT Gene:
TERT (telomerase reverse transcriptase) is a protein-coding gene. Diseases associated with TERT include bone marrow failure, telomere-related, 1, and pulmonary fibrosis, familial. GO annotations related to this gene include telomerase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746
Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most
eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells.
Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by
acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template
sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini
with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer
extension and release of product once the template boundary has been reached or nascent product translocation
followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity
is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide
modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis

summary for TERT Gene:
Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme,
telomerase reverse transcriptase (TERT). Telomerase adds small repeat sequences of DNA (TTAGGG) to the end
of chromosomes - multiple repeats of this hexanucleotide sequence over a 5kb span are known as a telomere.
During normal cellular replication, telomeres are eroded and thus protect the coding sequences of the DNA.
The erosion of telomeric sequences is thought to form the basis of the cellular clock which eventually
signals for the cell to exit the cell cycle and undergo senescence. Expression of telomerase is low in most
normal cells although it is thought to be active in embryonic cells and some rapidly dividing cells of the
immune system. Overexpression of telomerase is key component of the transformation process in many malignant
cancer cells.

Gene Wiki entry for TERT (Telomerase reverse transcriptase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TERT gene promoter:
         Egr-3   AP-1   Sp1   p53   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TERT

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TERT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

TERT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TERT gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001253:  view genomic region     (about GC identifiers)

1,253,262 bp from pter      End:
1,295,184 bp from pter
41,923 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746 (See protein sequence)
Recommended Name: Telomerase reverse transcriptase  
Size: 1132 amino acids; 126997 Da
Subunit: Homodimer; dimerization is required to produce a functional complex. Oligomer; can form oligomers in the
absence of the telomerase RNA template component (TERC). Catalytic subunit of the telomerase holoenzyme complex
composed minimally of TERT and TERC. The telomerase complex is composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2,
GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). The molecular chaperone HSP90/P23 complex
is required for correct assembly and stabilization of the active telomerase. Interacts directly with HSP90A and
PTGES3. Interacts with HSPA1A; the interaction occurs in the absence of TERC and dissociates once the complex has
formed. Interacts with RAN; the interaction promotes nuclear export of TERT. Interacts with XPO1. Interacts with
PTPN11; the interaction retains TERT in the nucleus. Interacts with NCL (via RRM1 and C-terminal
RRM4/Arg/Gly-rich domains); the interaction is important for nucleolar localization of TERT. Interacts with
SMARCA4 (via the bromodomain); the interaction regulates Wnt-mediated signaling. Interacts with MCRS1 (isoform
MCRS2); the interaction inhibits in vitro telomerase activity. Interacts with PIF1; the interaction has no effect
on the elongation activity of TERT. Interacts with PML; the interaction recruits TERT to PML bodies and inhibits
telomerase activity. Interacts with GNL3L (By similarity)
3 PDB 3D structures from and Proteopedia for TERT:
2BCK (3D)        4B18 (3D)        4MNQ (3D)    
Secondary accessions: O14783 Q2XS35 Q8N6C3 Q8NG38 Q8NG46
Alternative splicing: 4 isoforms:  O14746-1   O14746-2   O14746-3   O14746-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TERT: NX_O14746

Explore proteomics data for TERT at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its
    antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227
    by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes
    ubiquitination by the EDVP complex and degradation1
  • Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2.
    Ubiquitinated leads to proteasomal degradation. In case of infection by HIV-1, the EDVP complex is hijacked by
    HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TERT (O14746) (see all 7)

    See TERT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180305.1  NP_937983.2  

    ENSEMBL proteins: 
     ENSP00000309572   ENSP00000425003   ENSP00000334346   ENSP00000426042   ENSP00000296820  
    Reactome Protein details: O14746

    TERT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TERT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TERT
    GenScript Custom Purified and Recombinant Proteins Services for TERT
    Novus Biologicals TERT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TERT

    Search eBioscience for Proteins for TERT 

    antibodies-online proteins for TERT (3 products) 

    antibodies-online peptides for TERT

    Search GeneTex for Proteins for TERT 

    TERT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TERT
    R&D Systems Antibodies for TERT
    OriGene Antibodies for TERT
    OriGene Custom Antibody Services for TERT
    Novus Biologicals TERT Antibodies
    Abcam antibodies for TERT
    Cloud-Clone Corp. Antibodies for TERT
    ThermoFisher Antibody for TERT
    antibodies-online antibodies for TERT (159 products) 

    GeneTex Antibodies for TERT:  
                        TERT Antibodies

    TERT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TERT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TERT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TERT
    Cloud-Clone Corp. CLIAs for TERT
    Search eBioscience for ELISAs for TERT 
    antibodies-online kits for TERT (50 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    3 InterPro protein domains:
     IPR003545 Telomerase_RT
     IPR000477 RT_dom
     IPR021891 Telomerase_RBD

    Graphical View of Domain Structure for InterPro Entry O14746

    ProtoNet protein and cluster: O14746

    1 Blocks protein domain: IPB003545 Telomere reverse transcriptase signature

    UniProtKB/Swiss-Prot: TERT_HUMAN, O14746
    Domain: The primer grip sequence in the RT domain is required for telomerase activity and for stable association
    with short telomeric primers
    Domain: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the
    pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream
    of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity
    Domain: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and
    for DNA synthesis
    Similarity: Belongs to the reverse transcriptase family. Telomerase subfamily
    Similarity: Contains 1 reverse transcriptase domain

    Find genes that share domains with TERT           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TERT_HUMAN, O14746
    Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most
    eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells.
    Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by
    acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template
    sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini
    with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer
    extension and release of product once the template boundary has been reached or nascent product translocation
    followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity
    is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide
    modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
    Induction: Activated by cytotoxic events and down-regulated during aging. In peripheral T-lymphocytes, induced By
    CD3 and by PMA/ionomycin. Inhibited by herbimycin B

         Genatlas biochemistry entry for TERT:
    telomerase,catalytic subunit,yeast Est2 homolog,100kDa,involved in telomere maintenance,putative up-regulated
    c-Myc target gene,protein activity deleted in cancer,repressed in normal tissues

         Enzyme Numbers (IUBMB): EC 2 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003720telomerase activity IDA12135483
    GO:0003721telomeric template RNA reverse transcriptase activity TAS14991929
    GO:0003723RNA binding ----
    GO:0003964RNA-directed DNA polymerase activity ----
    GO:0005515protein binding IPI12699629
    Find genes that share ontologies with TERT           About GenesLikeMe

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Tert):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  normal 
     reproductive system  skeleton  taste/olfaction  tumorigenesis 

    Find genes that share phenotypes with TERT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TERT: Terttm1Sear Terttm1Fish Terttm1Rdp Terttm1Yjc Terttm1Leah

       genOway: Develop your customized and physiologically relevant rodent model for TERT

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for TERT

    miRTarBase miRNAs that target TERT:
    hsa-mir-138-5p (MIRT003991), hsa-mir-498 (MIRT006931), hsa-mir-335-5p (MIRT017613), hsa-mir-193b-3p (MIRT016371)

    Block miRNA regulation of human, mouse, rat TERT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TERT
    SwitchGear 3'UTR luciferase reporter plasmidTERT 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for TERT
    Predesigned siRNA for gene silencing in human, mouse, rat TERT

    OriGene clones in human, mouse for TERT (see all 13)
    OriGene ORF clones in mouse, rat for TERT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TERT (NM_198253)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TERT
    Addgene plasmids for TERT 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for TERT
    Browse ESI BIO Cell Lines and PureStem Progenitors for TERT 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TERT

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-11742) for TERT 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    TERT_HUMAN, O14746: Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus,
    PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states,
    transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell
    types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative
    stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus.
    Translocated to the nucleus by phosphorylation by AKT
    Subcellular locations from COMPARTMENTS: 

    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IC12135483
    GO:0000783nuclear telomere cap complex IC15632080
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005697telomerase holoenzyme complex IDA12135483

    Find genes that share ontologies with TERT           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for TERT About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Telomere C-strand (Lagging Strand) Synthesis
    Extension of Telomeres0.79
    Telomere Extension By Telomerase0.00
    2Packaging Of Telomere Ends
    Telomere Maintenance0.64
    Chromosome Maintenance0.62
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4Apoptotic Pathways in Synovial Fibroblasts
    Telomerase Components in Cell Signaling0.72
    5IL2 signaling events mediated by PI3K
    IL2 signaling events mediated by PI3K0.34

    Find genes that share SuperPaths with TERT           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TERT
        Telomerase Components in Cell Signaling
    14-3-3 and Regulation of BAD Activity
    Telomere Extension by Telomerase

    Selected BioSystems Pathways for TERT (see all 6)
        Id Signaling Pathway
    IL2 signaling events mediated by PI3K
    Regulation of Telomerase
    HIF-1-alpha transcription factor network
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    2 Reactome Pathways for TERT
        Telomere Extension By Telomerase
    formation of the beta-catenin:TCF transactivating complex

    1 Kegg Pathway  (Kegg details for TERT):
        HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TERT (see all 9): 
              Lung Cancer in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Liver Cancer in human mouse rat
              Stem Cells in human mouse rat
              Cancer Drug Targets in human mouse rat


        GeneGlobe Interaction Network for TERT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TERT (O147461, 2, 3 ENSP000003095724) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 2, 3, ENSP000002628034EBI-1772203,EBI-373471 MINT-8286561 MINT-8286551 MINT-8286579 I2D: score=1 STRING: ENSP00000262803
    PMLP29590-51, ENSP000002680584EBI-1772203,EBI-304008 I2D: score=1 STRING: ENSP00000268058
    AKT1P317492, 3, ENSP000002702024MINT-6742762 I2D: score=3 STRING: ENSP00000270202
    RUVBL1Q9Y2651, 3, ENSP000003182974EBI-1772203,EBI-353675 I2D: score=1 STRING: ENSP00000318297
    CIB1Q998283, ENSP000003338734I2D: score=2 STRING: ENSP00000333873
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS12135483
    GO:0006278RNA-dependent DNA replication ----
    GO:0007004telomere maintenance via telomerase TAS--
    GO:0022616DNA strand elongation IDA16043710
    GO:0032203telomere formation via telomerase IDA16043710

    Find genes that share ontologies with TERT           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TERT
      Browse compounds at ApexBio 

    Compounds for TERT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TMPyP4 tosylateInhibitor of human telomerase[36951-72-1]
    BIBR 1532Selective telomerase inhibitor[321674-73-1]
    CostunolideInhibitor of human telomerase activity[553-21-9]

    2 HMDB Compounds for TERT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for TERT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZidovudineAzidothymidine (see all 3)30516-87-1targetinhibitor23303810

    Selected Novoseek inferred chemical compound relationships for TERT gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 59.3 7 12007281 (2), 11494028 (1), 19419704 (1), 18669893 (1)
    lipofectamine 36.4 1 17495775 (1)
    ganciclovir 26.4 4 19328781 (1), 15312323 (1), 17407070 (1), 19809268 (1)
    retinoic acid 25.4 12 12529350 (2), 15236314 (2), 12939463 (1), 14592454 (1) (see all 7)
    ly294002 24.5 2 16093915 (1)
    depsipeptide 22.8 2 17610380 (1), 15791453 (1)
    oligonucleotide 17.5 5 12838868 (1), 17991312 (1), 12519411 (1)
    cisplatin 16.5 4 11877097 (1), 17923759 (1), 19639202 (1), 11384107 (1)
    etoposide 14 3 12594176 (1), 11718848 (1)
    5-aza-2'deoxycytidine 13.9 2 15805278 (1)

    Find genes that share compounds with TERT           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for TERT gene (4 alternative transcripts): 
    NM_001193376.1  NM_198253.2  NM_198254.1  NM_198255.2  

    Unigene Cluster for TERT:

    Telomerase reverse transcriptase
    Hs.492203  [show with all ESTs]
    Unigene Representative Sequence: AF018167
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484238(uc003jbz.1 uc021xvz.1) ENST00000310581(uc003jcb.1 uc003jcc.1 uc003jca.1 uc003jcd.1 uc003jce.1)
    ENST00000460137 ENST00000334602 ENST00000503656 ENST00000508104 ENST00000522877
    ENST00000296820(uc021xwa.1 uc021xwb.1 uc021xwc.1)
    Block miRNA regulation of human, mouse, rat TERT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TERT
    SwitchGear 3'UTR luciferase reporter plasmidTERT 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for TERT
    Predesigned siRNA for gene silencing in human, mouse, rat TERT
    OriGene clones in human, mouse for TERT (see all 13)
    OriGene ORF clones in mouse, rat for TERT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TERT (NM_198253)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TERT
    Addgene plasmids for TERT 
    OriGene qSTAR qPCR primer pairs in human, mouse for TERT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TERT
      QuantiTect SYBR Green Assays in human, mouse, rat TERT
      QuantiFast Probe-based Assays in human, mouse, rat TERT
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-11742) for TERT 

    Additional mRNA sequence: 

    AB085628.1 AF015950.1 AF018167.1 BC062321.1 JF896280.1 JF896281.1 JF896282.1 JF896283.1 
    JF896284.1 JF896285.1 JF896286.1 

    3 DOTS entries:

    DT.108983  DT.101961620  DT.40268927 

    Selected AceView cDNA sequences (see all 29):

    AB085628 NM_198254 AB086950 AW276315 AX810038 AF015950 AI824948 NM_198255 
    NM_198253 AX810036 NM_003219 BC062321 AB086379 AF018167 BE514070 AX810043 
    BM453198 BE514188 AX810378 AA811084 AW270031 AA281296 BM824748 AA299878 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TERT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -                                                                                                   
    SP2:                    -                                                           -                                       
    SP3:                    -                                   -     -                 -                                       
    SP4:                    -                       -           -     -                 -                                       
    SP5:                                                        -     -                                                         

    ECgene alternative splicing isoforms for TERT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TERT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    TERT Expression
    About this image

    TERT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 12 entries
             Line H7 (WA07)
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian tissue-dissociated cells
             Ddx4-positive cells
             Human oogonial stem cells
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             GLP-transfected mesenchymal stem cells
    TERT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TERT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492203

    UniProtKB/Swiss-Prot: TERT_HUMAN, O14746
    Tissue specificity: Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil
    T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TERT (see all 9): 
              Lung Cancer in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Liver Cancer in human mouse rat
              Stem Cells in human mouse rat
              Cancer Drug Targets in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for TERT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TERT
    QuantiTect SYBR Green Assays in human, mouse, rat TERT
    QuantiFast Probe-based Assays in human, mouse, rat TERT
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TERT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TERT gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Tert1 , 5 telomerase reverse transcriptase1, 5 70.94(n)1
      13 (40.12 cM)5
    217521  NM_009354.11  NP_033380.11 
    (Gallus gallus)
    Aves TERT1 telomerase reverse transcriptase 59.06(n)
      420972  NM_001031007.1  NP_001026178.1 
    (Anolis carolinensis)
    Reptilia TERT6
    Uncharacterized protein
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia tert-A2 telomerase reverse transcriptase 71.34(n)    AF212299.1 
    (Danio rerio)
    Actinopterygii tert1 telomerase reverse transcriptase 50.65(n)
      796551  NM_001083866.1  NP_001077335.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EST2(YLR318W)4 Reverse transcriptase subunit of the telomerase holoenzyme, more   --   12(766542-769196) 851028  NP_013422.1 

    ENSEMBL Gene Tree for TERT (if available)
    TreeFam Gene Tree for TERT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for TERT gene
    1 SIMAP similar gene for TERT using alignment to 7 protein entries:     TERT_HUMAN (see all proteins):

    Find genes that share paralogs with TERT           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for TERT (see all 1753)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 5 posSequence#AA
    CPulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4 --1272311(+) GATGAC/TGACGG 4 I V mis10--------
    CPulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4 pathogenic11293767(-) AGACGC/TACTGC 4 H Y mis16Minor allele frequency- T:0.00NS NA 192
    Dyskeratosis congenita, autosomal dominant, 2 (DKCA2)4--see VAR_0625442 F L mis40--------
    Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4--see VAR_0368702 V M mis40--------
    Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4--see VAR_0687982 K R mis40--------
    Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4--see VAR_0368632 A T mis40--------
    Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4--see VAR_0368682 R H mis40--------
    Dyskeratosis congenita, autosomal dominant, 2 (DKCA2)4--see VAR_0368692 K N mis40--------
    Dyskeratosis congenita, autosomal recessive, 4 (DKCB4)4--see VAR_0625382 P R mis40--------
    Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1)4--see VAR_0687992 P L mis40--------

    HapMap Linkage Disequilibrium report for TERT (1253262 - 1295184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TERT (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729466CNV Deletion23290073
    esv2729458CNV Deletion23290073
    esv2742056CNV Deletion23290073
    esv1454284CNV Deletion17803354
    esv2729475CNV Deletion23290073
    esv2729470CNV Deletion23290073
    esv2729456CNV Deletion23290073
    esv2729455CNV Deletion23290073
    esv2729460CNV Deletion23290073
    esv2729467CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TERT
    Locus Specific Mutation Databases (LSDB): TERT

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TERT:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing TERT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 187270   
    OMIM disorders: 614742  613989  601626  615134  
    UniProtKB/Swiss-Prot: TERT_HUMAN, O14746
  • Note=Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis
  • Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate
    numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
  • Note=Genetic variations in TERT are associated with coronary artery disease (CAD)
  • Dyskeratosis congenita, autosomal dominant, 2 (DKCA2) [MIM:613989]: A rare multisystem disorder caused by
    defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of
    reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include
    premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among
    others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications,
    or malignancy. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1 (PFBMFT1) [MIM:614742]: A disease
    associated with shortened telomeres. Pulmonary fibrosis is the most common manifestation. Other manifestations
    include aplastic anemia due to bone marrow failure, hepatic fibrosis, and increased cancer risk, particularly
    myelodysplastic syndrome and acute myeloid leukemia. Phenotype, age at onset, and severity are determined by
    telomere length. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Dyskeratosis congenita, autosomal recessive, 4 (DKCB4) [MIM:613989]: A severe form of dyskeratosis
    congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by
    progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy,
    and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets,
    osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone
    marrow failure, infections, fatal pulmonary complications, or malignancy. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath,
    radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on
    biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury
    with subsequent scarring and end-stage lung disease. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry
  • Melanoma, cutaneous malignant 9 (CMM9) [MIM:615134]: A malignant neoplasm of melanocytes, arising de novo
    or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for TERT (see all 31):    
    About MalaCards
    bone marrow failure, telomere-related, 1    pulmonary fibrosis, familial    pulmonary fibrosis, telomere-related, 1    dyskeratosis congenita, autosomal recessive 4
    dyskeratosis congenita, autosomal dominant 2    melanoma, cutaneous malignant, 9    tert-related dyskeratosis congenita    tert-related familial pulmonary fibrosis
    bowenoid papulosis    idiopathic pulmonary fibrosis    acute myeloid leukemia    pulmonary fibrosis
    aplastic anemia    mixed ductal-endocrine carcinoma    tongue cancer    vulvar intraepithelial neoplasia
    medulloepithelioma    dyskeratosis congenita    benign meningioma    biliary tract disease

    3 inferred disease relationships from the University of Copenhagen DISEASES database for TERT:
    Dyskeratosis congenita     Cancer     Idiopathic pulmonary fibrosis

    Find genes that share disorders with TERT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TERT gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyskeratosis congenita 85 10 15885610 (2), 17454774 (1), 17468339 (1), 19415813 (1) (see all 9)
    dyskeratosis congenita, autosomal dominant 77.5 6 16247010 (1), 17392301 (1), 18460650 (1), 17875000 (1) (see all 5)
    cancer 73.1 215 20478107 (4), 11934015 (4), 14532739 (4), 19809268 (3) (see all 99)
    tumors 69.5 256 10973321 (5), 17130181 (5), 18204433 (5), 17656250 (4) (see all 99)
    hepatocellular carcinoma 57 32 19627485 (2), 18753050 (2), 11944954 (2), 15143919 (2) (see all 27)
    laryngeal squamous cell carcinoma 54.7 13 17592663 (2), 17219990 (2), 15823813 (2), 11911285 (2) (see all 8)
    anemia aplastic 47.6 12 15814878 (2), 15885610 (2), 17625368 (1), 17640862 (1) (see all 8)
    benign meningioma 47.2 2 17227292 (1), 17415213 (1)
    precancerous lesions 47 8 10429648 (2), 14716817 (2), 11906620 (1), 10779229 (1) (see all 5)
    premalignant 44.7 4 14575609 (1), 17581401 (1), 9620778 (1), 9731489 (1)

    GeneTests: TERT
    GeneReviews: TERT
    Genetic Association Database (GAD): TERT
    Human Genome Epidemiology (HuGE) Navigator: TERT (64 documents)

    Export disorders for TERT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TERT gene, integrated from 10 sources (see all 1601) (see top 10):
    (articles sorted by number of sources associating them with TERT)

    1. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. (PubMed id 15814878)1, 2, 4, 9 Yamaguchi H.... Young N.S. (N. Engl. J. Med. 2005)
    2. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. (PubMed id 19147845)1, 2, 4, 9 Calado R.T.... Young N.S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Mutations in telomerase catalytic protein in Japanese children with aplastic anemia. (PubMed id 16627250)1, 2, 4, 9 Liang J.... Kojima S. (Haematologica 2006)
    4. Coronary artery disease and a functional polymorphism of hTERT. (PubMed id 16890917)1, 2, 4 Matsubara Y.... Ikeda Y. (Biochem. Biophys. Res. Commun. 2006)
    5. Telomerase catalytic subunit homologs from fission yeast and human. (PubMed id 9252327)1, 2, 3 Nakamura T.M.... Cech T.R. (Science 1997)
    6. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. (PubMed id 12808100)1, 2, 9 Haendeler J.... Dimmeler S. (Mol. Cell. Biol. 2003)
    7. PML-IV functions as a negative regulator of telomerase by interacting with TERT. (PubMed id 19567472)1, 2, 9 Oh W.... Song J. (J. Cell Sci. 2009)
    8. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. (PubMed id 18829466)1, 2, 9 Jakob S.... Haendeler J. (J. Biol. Chem. 2008)
    9. Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. (PubMed id 17785587)1, 2, 9 Marrone A.... Dokal I. (Blood 2007)
    10. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. (PubMed id 18931339)1, 4, 9 Du H.Y....Bessler M. (Blood 2009)
    11. Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. (PubMed id 15885610)1, 2, 9 Vulliamy T.J....Dokal I. (Blood Cells Mol. Dis. 2005)
    12. Telomere shortening in familial and sporadic pulmonary fibrosis. (PubMed id 18635888)1, 4, 9 Cronkhite J.T....Garcia C.K. (Am. J. Respir. Crit. Care Med. 2008)
    13. Adult-onset pulmonary fibrosis caused by mutations in telomerase. (PubMed id 17460043)1, 2, 9 Tsakiri K.D.... Garcia C.K. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    14. Human telomerase contains evolutionarily conserved catalytic and structural subunits. (PubMed id 9389643)1, 2, 9 Harrington L.... Robinson M.O. (Genes Dev. 1997)
    15. Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. (PubMed id 19369581)1, 4, 9 Jin G....Shen H. (Carcinogenesis 2009)
    16. A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer. (PubMed id 19380022)1, 4, 9 Varadi V....FAPrsti A. (Cancer Genet. Cytogenet. 2009)
    17. Multiple genetic variants in telomere pathway genes and breast cancer risk. (PubMed id 20056641)1, 4, 9 Shen J....Santella R.M. (amp 2010)
    18. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. (PubMed id 20061363)1, 4, 9 Kohno T....Yokota J. (Carcinogenesis 2010)
    19. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. (PubMed id 19285750)1, 4, 9 Hosgood H.D....Lan Q. (Lung Cancer 2009)
    20. Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia. (PubMed id 19760749)1, 2, 9 Kirwan M.... Dokal I. (Hum. Mutat. 2009)
    21. Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. (PubMed id 19766477)1, 4, 9 Varadi V....FAPrsti A. (Eur. J. Cancer 2009)
    22. Polymorphisms in telomere maintenance genes and risk of lung cancer. (PubMed id 19773453)1, 4, 9 Choi J.E....Park J.Y. (amp 2009)
    23. Lung cancer susceptibility locus at 5p15.33. (PubMed id 18978790)1, 4, 9 McKay J.D....Brennan P. (Nat. Genet. 2008)
    24. A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. (PubMed id 18835860)1, 4, 9 Mushiroda T....Nakamura Y. (J. Med. Genet. 2008)
    25. Telomerase mutations in families with idiopathic pulmonary fibrosis. (PubMed id 17392301)1, 2, 9 Armanios M.Y.... Loyd J.E. (N. Engl. J. Med. 2007)
    26. Genetic variation in five genes important in telomere biology and risk for breast cancer. (PubMed id 17848914)1, 4, 9 Savage S.A....Garcia-Closas M. (Br. J. Cancer 2007)
    27. hEST2, the putative human telomerase catalytic subunit gene, is up- regulated in tumor cells and during immortalization. (PubMed id 9288757)1, 2, 9 Meyerson M.... Weinberg R.A. (Cell 1997)
    28. TERT promoter mutations in familial and sporadic melanoma. (PubMed id 23348503)1, 2 Horn S....Kumar R. (Science 2013)
    29. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PubMed id 23362280)1, 2 Jung H.Y....Park J.I. (J. Biol. Chem. 2013)
    30. HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex. (PubMed id 23612978)1, 2 Wang X....Park J.I. (J. Biol. Chem. 2013)
    31. Pulmonary fibrosis, bone marrow failure, and telomerase mutation. (PubMed id 22512499)1, 2 Gansner J.M.... Ebert B.L. (N. Engl. J. Med. 2012)
    32. Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. (PubMed id 22366458)1, 2 Chung J.... Chung I.K. (J. Cell Sci. 2012)
    33. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. (PubMed id 21725308)1, 4 Hu Z....Shen H. (Nat. Genet. 2011)
    34. Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk. (PubMed id 21827660)1, 4 Yang T.H....Delisi C. (BMC Med Genomics 2011)
    35. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. (PubMed id 21436073)1, 2 Parry E.M.... Armanios M. (Blood 2011)
    36. Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. (PubMed id 21483807)1, 2 Alder J.K.... Armanios M. (PLoS Genet. 2011)
    37. Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer. (PubMed id 21083788)1, 4 Jin G....Park J.Y. (Cancer Sci. 2011)
    38. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. (PubMed id 20937264)1, 4 Zee R.Y....Chasman D.I. ( international journal of clinical chemistry 2011)
    39. Chromosome 7p11.2 (EGFR) variation influences glioma risk. (PubMed id 21531791)1, 4 Sanson M....Simon M. (Hum. Mol. Genet. 2011)
    40. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. (PubMed id 21081471)1, 4 Gago-Dominguez M....Van Den Berg D.J. (Carcinogenesis 2011)
    41. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. (PubMed id 21743467)1, 4 Kote-Jarai Z....TybjA ( 2011)
    42. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    43. Interaction between 5 genetic variants and allergy in glioma risk. (PubMed id 20462933)1, 4 Schoemaker M.J....Swerdlow A.J. (Am. J. Epidemiol. 2010)
    44. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    45. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    46. Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. (PubMed id 20802237)1, 4 Liu Z....Wei Q. (Carcinogenesis 2010)
    47. Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. (PubMed id 19955392)1, 4 Wang Y....Houlston R.S. (Carcinogenesis 2010)
    48. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. (PubMed id 20700438)1, 4 Hsiung C.A....Lin D. (PLoS Genet. 2010)
    49. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    50. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. (PubMed id 20543847)1, 4 Turnbull C.... Rahman N. (Nat. Genet. 2010)
    51. A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer. (PubMed id 20466886)1, 4 Wang L....Wei Q. (Clin. Cancer Res. 2010)
    52. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. (PubMed id 19915151)1, 4 Atzmon G....Suh Y. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    53. Prognostic significance of telomerase polymorphism in non-small cell lung cancer. (PubMed id 20606038)1, 4 Catarino R....Medeiros R.M. (Clin. Cancer Res. 2010)
    54. Genetic risk profiles identify different molecular etiologies for glioma. (PubMed id 20847058)1, 4 Simon M....Sanson M. (Clin. Cancer Res. 2010)
    55. Telomere length and genetic analyses in population-based studies of endometrial cancer risk. (PubMed id 20549820)1, 4 Prescott J....De Vivo I. (Cancer 2010)
    56. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    57. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. (PubMed id 20871597)1, 4 Miki D....Daigo Y. (Nat. Genet. 2010)
    58. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    59. Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression. (PubMed id 20659312)1, 4 Yoon S.L....Leem S.H. (BMC Cancer 2010)
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    64. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. (PubMed id 19836008)1, 4 Landi M.T....Caporaso N.E. (Am. J. Hum. Genet. 2009)
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    67. MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome. (PubMed id 19405125)1, 4 Andersson U....Malmer B. (Int. J. Cancer 2009)
    68. The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. (PubMed id 19465454)1, 4 Zienolddiny S....Haugen A. (Carcinogenesis 2009)
    69. Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. (PubMed id 19777057)1, 2 Wyatt H.D.... Beattie T.L. (PLoS ONE 2009)
    70. Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. (PubMed id 18042801)1, 2 Du H.Y.... Bessler M. (Blood 2008)
    71. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    72. Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes. (PubMed id 17936651)1, 4 Takeuchi J....Dan K. (amp 2008)
    73. The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. (PubMed id 17264120)1, 2 Drosopoulos W.C. and Prasad V.R. (Nucleic Acids Res. 2007)
    74. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. (PubMed id 18082603)1, 2 Fu D. and Collins K. (Mol. Cell 2007)
    75. Characterization of physical and functional anchor site interactions in human telomerase. (PubMed id 17296728)1, 2 Wyatt H.D.... Beattie T.L. (Mol. Cell. Biol. 2007)
    76. Association of telomerase gene hTERT polymorphism and malignant gliomas. (PubMed id 17410334)1, 4 Carpentier C....Sanson M. (J. Neurooncol. 2007)
    77. hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood. (PubMed id 17481586)1, 4 NordfjAoll K....Roos G. (Biochem. Biophys. Res. Commun. 2007)
    78. Functional characterization of natural telomerase mutations found in patients with hematologic disorders. (PubMed id 16990594)1, 2 Xin Z.T.... Ly H. (Blood 2007)
    79. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. (PubMed id 15805468)1, 2 Kim J.H....Chung I.K. (Genes Dev. 2005)
    80. An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. (PubMed id 15857955)1, 2 Moriarty T.J.... Autexier C. (Mol. Biol. Cell 2005)
    81. Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. (PubMed id 15082768)1, 2 Moriarty T.J.... Autexier C. (Mol. Cell. Biol. 2004)
    82. Nucleolin interacts with telomerase. (PubMed id 15371412)1, 2 Khurts S.... Murakami S. (J. Biol. Chem. 2004)
    83. Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines. (PubMed id 14654914)1, 2 Nagao K.... Hisatomi H. (Oncol. Rep. 2004)
    84. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PubMed id 15044100)1, 2 Song H....Zhao M. (Biochem. Biophys. Res. Commun. 2004)
    85. Immunohistochemical localization of hTERT protein in human tissues. (PubMed id 15138842)1, 2 Yan P.... Bosman F.T. (Histochem. Cell Biol. 2004)
    86. Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene. (PubMed id 12869302)1, 2 Hisatomi H.... Tsukada Y. (Neoplasia 2003)
    87. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. (PubMed id 11274138)1, 2 Forsythe H.L.... Holt S.E. (J. Biol. Chem. 2001)
    88. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. (PubMed id 11029039)1, 2 Beattie T.L.... Harrington L. (Mol. Biol. Cell 2000)
    89. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). (PubMed id 10333526)1, 2 Wick M.... Hagen G. (Gene 1999)
    90. Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. (PubMed id 16785237)1, 9 Li H....Liu J.P. (J. Biol. Chem. 2006)
    91. Differential regulation of human and mouse telomerase reverse transcriptase (TERT) promoter activity during testis development. (PubMed id 18729084)1, 9 Weise J.M. and GA1neA9 C. (Mol. Reprod. Dev. 2009)
    92. MYC amplification and TERT expression in breast tumor progression. (PubMed id 17656250)1, 9 BodvarsdA^ttir S.K....EyfjAPrd J.E. (Cancer Genet. Cytogenet. 2007)
    93. Quantitative and spatial measurements of telomerase reverse transcriptase expression within normal and malignant human breast tissues. (PubMed id 16179497)1, 9 Hines W.C....Griffith J.K. (Mol. Cancer Res. 2005)
    94. TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability. (PubMed id 12594176)1, 9 Zhang P....Mattson M.P. (FASEB J. 2003)
    95. Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer. (PubMed id 11934015)1, 9 Zhao P....Wang D. (J. Environ. Pathol. Toxicol. Oncol. 2002)
    96. Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. (PubMed id 20502709)1, 9 Diaz de Leon A....Garcia C.K. (PLoS ONE 2010)
    97. A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. (PubMed id 18203676)1, 9 Yang C....Lako M. (Stem Cells 2008)
    98. Direct activation of TERT transcription by c-MYC. (PubMed id 9988278)1, 9 Wu K.J.... Dalla-Favera R. (Nat. Genet. 1999)
    99. Nucleolar localization of TERT is unrelated to telomerase function in human cells. (PubMed id 18522991)1, 9 Lin J....Huang J.J. (J. Cell. Sci. 2008)
    100. Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. (PubMed id 16507993)1, 9 Middleman E.J....Artandi S.E. (Mol. Cell. Biol. 2006)
    101. Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). (PubMed id 18042045)1, 9 Ito T....Iba H. (Biochem. J. 2008)
    102. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. (PubMed id 17875000)1, 9 Du H.Y....Bessler M. (Aging Cell 2007)
    103. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. (PubMed id 14963003)2, 9 Haendeler J.... Dimmeler S. (Circ. Res. 2004)
    104. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. (PubMed id 9620778)1, 9 Kolquist K.A....Gerald W.L. (Nat. Genet. 1998)
    105. Hepatitis C virus core protein enhances Telomerase activity in Huh7 cells. (PubMed id 20029802)1, 9 Zhu Z....Schmidt W.N. (J. Med. Virol. 2010)
    106. Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. (PubMed id 18204433)1, 9 Horvai A.E....O'Donnell R.J. (Mod. Pathol. 2008)
    107. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. (PubMed id 18069666)1, 9 Mantripragada K.K....Upadhyaya M. (amp 2008)
    108. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. (PubMed id 12586360)1, 9 Haendeler J....Dimmeler S. (FEBS Lett. 2003)
    109. BRCA1 inhibition of telomerase activity in cultured cells. (PubMed id 14612409)1, 9 Xiong J....Rosen E.M. (Mol. Cell. Biol. 2003)
    110. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. (PubMed id 11322991)1, 9 Mattson M.P....Zhang P. (Mech. Ageing Dev. 2001)
    111. Reconstitution of human telomerase activity in vitro. (PubMed id 9443919)2, 9 Beattie T.L.... Harrington L. (Curr. Biol. 1998)
    112. Variation at the TERT locus and predisposition for cancer. (PubMed id 20478107)1, 9 Baird D.M. (Expert Rev Mol Med 2010)
    113. Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. (PubMed id 20022961)1, 9 Robart A.R. and Collins K. (J. Biol. Chem. 2010)
    114. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. (PubMed id 19701182)1, 9 Maida Y....Masutomi K. (Nature 2009)
    115. Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. (PubMed id 20032382)1, 9 SchjA...De Angelis P.M. (Anticancer Res. 2009)
    116. Differential repression of human and mouse TERT genes during cell differentiation. (PubMed id 19270068)1, 9 Wang S....Zhu J. (Nucleic Acids Res. 2009)
    117. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. (PubMed id 18358808)1, 9 Venteicher A.S....Artandi S.E. (Cell 2008)
    118. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. (PubMed id 18158869)1, 9 Wang F.Z....Zhang X.D. (Acta Pharmacol. Sin. 2008)
    119. C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. (PubMed id 12167716)1, 9 Banik S.S....Counter C.M. (Mol. Cell. Biol. 2002)
    120. Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer. (PubMed id 19414359)1, 9 Metzger R....Schneider P.M. (Anticancer Res. 2009)
    121. Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression. (PubMed id 19287963)1, 9 Furuya M....Watanabe N. (Int. J. Oncol. 2009)
    122. Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells. (PubMed id 18952593)1, 9 Chatagnon A....Dante R. (Carcinogenesis 2009)
    123. Human telomerase reverse transcriptase (hTERT) expression in borderline ovarian tumors: an immunohistochemical study. (PubMed id 19301721)1, 9 Tantbirojn P....Niruthisard S. (J Med Assoc Thai 2009)
    124. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)1, 9 Liu L.... Nakao M. (J. Biol. Chem. 2009)
    125. Predictive value of telomerase reverse transcriptase expression in patients with high risk superficial bladder cancer treated with adjuvant BCG immunotherapy. (PubMed id 19214569)1, 9 Zachos I....Papavassiliou A.G. (J. Cancer Res. Clin. Oncol. 2009)
    126. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. (PubMed id 18632625)1, 9 Chen Y.J....Royds J.A. (Cancer Res. 2008)
    127. Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. (PubMed id 18562689)1, 9 Tomlinson R.L....Terns M.P. (Mol. Biol. Cell 2008)
    128. Inhibition of telomerase with human telomerase reverse transcriptase antisense increases the sensitivity of tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells. (PubMed id 17712489)1, 9 Gao X.D. and Chen Y.R. (Asian J. Androl. 2007)
    129. Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha. (PubMed id 16979586)1, 9 Jagadeesh S. and Banerjee P.P. (Biochem. Biophys. Res. Commun. 2006)
    130. Enhanced antitumor effect against human telomerase reverse transcriptase (hTERT) by vaccination with chemotactic-hTERT gene-modified tumor cell and the combination with anti-4-1BB monoclonal antibodies. (PubMed id 16708388)1, 9 Lin X....Zhang S. (Int. J. Cancer 2006)
    131. Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients. (PubMed id 16372125)1, 9 Weikert S....Schrader M. (Asian J. Androl. 2006)
    132. [Expression of telomerase reverse transcriptase and its relationship with expression of c-myc in laryngeal squamous cell carcinomas]. (PubMed id 17219990)1, 9 Chen Z....Jiang M. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2006)
    133. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells. (PubMed id 15746653)1, 9 Zhang X....Ye L. (J. Lab. Clin. Med. 2005)
    134. [Expression of human telomerase reverse transcriptase in cervix cancer and its significance]. (PubMed id 16008894)1, 9 Xi L....Ma D. (Zhonghua Fu Chan Ke Za Zhi 2005)
    135. Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions. (PubMed id 14716817)1, 9 Wang W....Yu B.P. (World J. Gastroenterol. 2004)
    136. Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells. (PubMed id 15201989)1, 9 Takeuchi H....Kondo S. (Int. J. Oncol. 2004)
    137. Expression of the human telomerase reverse transcriptase in pheochromocytoma and neuroblastoma tissues. (PubMed id 15004408)1, 9 Isobe K....Nakai T. (Endocr. J. 2004)
    138. Constitutive overexpression of human telomerase reverse transcriptase but not c-myc blocks terminal differentiation in human HaCaT skin keratinocytes. (PubMed id 12839571)1, 9 Cerezo A....Boukamp P. (J. Invest. Dermatol. 2003)
    139. Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers. (PubMed id 12529350)1, 9 Soria J.C....Lotan R. (J. Natl. Cancer Inst. 2003)
    140. [Relationship between human telomerase reverse transcriptase transcriptional level and telomerase activity in three ovarian cancer cell lines]. (PubMed id 12753708)1, 9 Song Y....Jiang S. (Ai Zheng 2003)
    141. Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. (PubMed id 20107884)1, 9 Liu H....Ma C. (Virus Genes 2010)
    142. Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. (PubMed id 19501078)1, 9 Strati A....Moutsatsou P. (Clin. Biochem. 2009)
    143. Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma. (PubMed id 19934306)1, 9 George J....Ray S.K. (Clin. Cancer Res. 2009)
    144. Phosphorylation status of Fas-associated death domain-containing protein regulates telomerase activity and strongly correlates with prostate cancer outcomes. (PubMed id 19955841)1, 9 Matsumura Y....Konishi N. (Pathobiology 2009)
    145. Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene driven with hTERT tumor specific promoter induces apoptosis. (PubMed id 19587531)1, 9 Zang G....Sun H. (amp 2009)
    146. Downregulation of telomerase activity in human promyelocytic cell line using RNA interference. (PubMed id 19415276)1, 9 Miri-Moghaddam E....Soheili Z.S. (Ann. Hematol. 2009)
    147. Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. (PubMed id 19015635)1, 9 Kang X....Park N.H. (Oncogene 2009)
    148. Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. (PubMed id 19903789)1, 9 Mai W....Minamoto T. (Clin. Cancer Res. 2009)
    149. Radiation enhances suicide gene therapy in radioresistant laryngeal squamous cell carcinoma via activation of a tumor-specific promoter. (PubMed id 19375219)1, 9 Liao Z....Zhou Y. (Cancer Lett. 2009)
    150. Circulating hTERT DNA in early breast cancer. (PubMed id 19596972)1, 9 Divella R....Quaranta M. (Anticancer Res. 2009)
    151. Growth arrest in ovarian cancer cells by hTERT inhibition short-hairpin RNA targeting human telomerase reverse transcriptase induces immediate growth inhibition but not necessarily induces apoptosis in ovarian cancer cells. (PubMed id 19909010)1, 9 Luo Y....Yao Z. (Cancer Invest. 2009)
    152. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)2, 9 Venteicher A.S.... Artandi S.E. (Science 2009)
    153. Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. (PubMed id 18816183)1, 9 Wang Y....Zeiger M.A. (Thyroid 2008)
    154. A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women. (PubMed id 18413362)1, 9 Wang Y....Shen H. (Carcinogenesis 2008)
    155. The evaluation of hTERT mRNA expression in acute leukemia children and 2 years follow-up of 40 cases. (PubMed id 18293058)1, 9 Cogulu O....Ozkinay F. (Int. J. Hematol. 2008)
    156. Expanding the clinical phenotype of autosomal dominant dyskeratosis congenita caused by TERT mutations. (PubMed id 18460650)1, 9 Basel-Vanagaite L....Vulliamy T. (Haematologica 2008)
    157. Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. (PubMed id 17960465)1, 9 Hashimoto Y....Hiyama E. (J. Gastrointest. Surg. 2008)
    158. Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development. (PubMed id 17991730)1, 9 Moehren U....Baniahmad A. (FASEB J. 2008)
    159. Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo. (PubMed id 18425331)1, 9 Kunze D....Wirth M.P. (Int. J. Oncol. 2008)
    160. Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice. (PubMed id 18285708)1, 9 Chen S.M....Tao Z.Z. (amp 2008)
    161. Early growth response-1 mediates downregulation of telomerase in cervical cancer. (PubMed id 18460021)1, 9 Akutagawa O....Isaka K. (Cancer Sci. 2008)
    162. Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease. (PubMed id 19010861)1, 9 Terrin L....De Rossi A. (Clin. Cancer Res. 2008)
    163. Real-time PCR quantification of human telomerase reverse transcriptase (hTERT) in colorectal cancer. (PubMed id 18038311)1, 9 Saleh S....Ho Y.H. (Pathology 2008)
    164. Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. (PubMed id 18938767)1, 9 Sipos F....Tulassay Z. (Scand. J. Gastroenterol. 2008)
    165. Methylation-related silencing of p14ARF gene correlates with telomerase activity and mRNA expression of human telomerase reverse transcriptase in hepatocellular carcinoma. (PubMed id 18683194)1, 9 Zhang C....Wei L. (J Surg Oncol 2008)
    166. Activation of the hTERT expression in squamous cell cervical carcinoma is not associated with gene amplification. (PubMed id 18636213)1, 9 Anedchenko E....Senchenko V. (Oncol. Rep. 2008)
    167. Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase. (PubMed id 18519947)1, 9 Grasselli A....Farsetti A. (Circ. Res. 2008)
    168. Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. (PubMed id 18701711)1, 9 Ridley L....Grundy R.G. (Neuro-oncology 2008)
    169. Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis. (PubMed id 19010833)1, 9 Cheng Y.W....Lee H. (Clin. Cancer Res. 2008)
    170. [The effect of shRNA targeting hTERT on telomerase and the expression of PCNA and Caspase-3 in nasopharyngeal carcinoma cells]. (PubMed id 18652315)1, 9 Shen Y....Tao Z. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    171. Human telomerase reverse transcriptase expression correlates with vascular endothelial growth factor-promoted tumor cell proliferation in prostate cancer. (PubMed id 18437586)1, 9 Tang J....Shi H. (Artif Cells Blood Substit Immobil Biotechnol 2008)
    172. Development of recombinant adeno-associated virus and adenovirus cocktail system for efficient hTERTC27 polypeptide-mediated cancer gene therapy. (PubMed id 18535618)1, 9 Gao Y....Lin M.C. (Cancer Gene Ther. 2008)
    173. Mutations of telomerase complex genes linked to bone marrow failures. (PubMed id 17625368)1, 9 Yamaguchi H. (J Nippon Med Sch 2007)
    174. Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic transformation. (PubMed id 17827040)1, 9 Nicholson I.P....Bennett D. (Vet. J. 2007)
    175. HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). (PubMed id 18078517)1, 9 Kuhlmann A.S....Duc Dodon M. (Retrovirology 2007)
    176. Protein composition of catalytically active human telomerase from immortal cells. (PubMed id 17395830)1, 9 Cohen S.B....Reddel R.R. (Science 2007)
    177. Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. (PubMed id 17233832)1, 9 Haga K....Kiyono T. (Cancer Sci. 2007)
    178. A novel peptide-nucleotide dual vaccine of human telomerase reverse transcriptase induces a potent cytotoxic T-cell response in vivo. (PubMed id 17462602)1, 9 Guo H....Fang D.C. (Biochem. Biophys. Res. Commun. 2007)
    179. Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines. (PubMed id 17671725)1, 9 Takano T....Miyauchi A. (Oncol. Rep. 2007)
    180. Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern. (PubMed id 17896808)1, 9 Sun Y....Cheung H. (J. Rheumatol. 2007)
    181. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. (PubMed id 17548428)1, 9 Wooten-Blanks L.G.... Ogretmen B. (FASEB J. 2007)
    182. Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells. (PubMed id 17630431)1, 9 Deng W.G....Ji L. (J. Biol. Chem. 2007)
    183. A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT. (PubMed id 17197440)1, 9 Rosenberger S....Boukamp P. (J. Biol. Chem. 2007)
    184. High expression of human telomerase reverse transcriptase in high-grade intraepithelial neoplasia and carcinoma of uterine cervix and its correlation with human papillomavirus infection. (PubMed id 17644806)1, 9 Wang P.H....Ko J.L. (Reprod Sci 2007)
    185. Protein phosphatase 2A (PP2A) has a potential role in CAPE-induced apoptosis of CCRF-CEM cells via effecting human telomerase reverse transcriptase activity. (PubMed id 17852432)1, 9 Avci C.B....Saydam G. (Hematology 2007)
    186. [Effects of sodium butyrate on growth, apoptosis and telomerase activity in Hep-2 cells]. (PubMed id 17432359)1, 9 Gao L....Cheng X.L. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    187. A genetic strategy to overcome the senescence of primary meningioma cell cultures. (PubMed id 16554968)1, 9 Baia G.S....Lal A. (J. Neurooncol. 2006)
    188. Regulation of telomerase activity by the p53 family member p73. (PubMed id 16205639)1, 9 Beitzinger M....Stiewe T. (Oncogene 2006)
    189. Upregulation of telomerase (hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus, virus persistence, or disease outcome in cervical cancer. (PubMed id 17041957)1, 9 Branca M....SyrjAonen K. (Diagn. Cytopathol. 2006)
    190. Expression of p16 and hTERT protein is associated with the presence of high-risk human papillomavirus in Bowenoid papulosis. (PubMed id 16919029)1, 9 Liu H....Tu Y. (J. Cutan. Pathol. 2006)
    191. Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway. (PubMed id 16619045)1, 9 Chapman E.J....Knowles M.A. (Oncogene 2006)
    192. Real-time quantitative analysis for human telomerase reverse transcriptase mRNA and human telomerase RNA component mRNA expressions as markers for clinicopathologic parameters in urinary bladder cancer. (PubMed id 16734859)1, 9 Takihana Y....Takeda M. (Int. J. Urol. 2006)
    193. Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice. (PubMed id 16877525)1, 9 Miyoshi T....Ninomiya Y. (FASEB J. 2006)
    194. Comparison between human-telomerase reverse transcriptase mRNA and alpha-fetoprotein mRNA as a predictive value for recurrence of hepatocellular carcinoma in living donor liver transplantation. (PubMed id 17175353)1, 9 Oya H....Hatakeyama K. (Transplant. Proc. 2006)
    195. Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients. (PubMed id 16830373)1, 9 Leelawat K....Tepaksorn P. (World J. Gastroenterol. 2006)
    196. IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. (PubMed id 15710386)1, 9 Lee S.H....Lee J.H. (FEBS Lett. 2005)
    197. Lack of telomerase activity in lung carcinoids is dependent on human telomerase reverse transcriptase transcription and alternative splicing and is associated with long telomeres. (PubMed id 15837730)1, 9 Zaffaroni N....Daidone M.G. (Clin. Cancer Res. 2005)
    198. Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription. (PubMed id 15817155)1, 9 Endoh T....Watanabe N. (Exp. Cell Res. 2005)
    199. The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas. (PubMed id 15679862)1, 9 Maes Ridder L. (Cell Prolif. 2005)
    200. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. (PubMed id 16093915)1, 9 Imanishi T....Nishio I. (J. Hypertens. 2005)
    201. Upstream stimulatory factor (USF) as a transcriptional suppressor of human telomerase reverse transcriptase (hTERT) in oral cancer cells. (PubMed id 16010690)1, 9 Chang J.T....Cheng A.J. (Mol. Carcinog. 2005)
    202. Telomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT). (PubMed id 15816620)1, 9 Ito Y....Miyauchi A. (Anticancer Res. 2005)
    203. [Influence of RNA interference targeting against human telomerase reverse transcriptase on expression of C-myc protein]. (PubMed id 16494045)1, 9 Chi H....Zhan H. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005)
    204. Histone deacetylation is directly involved in desilencing the expression of the catalytic subunit of telomerase in normal lung fibroblast. (PubMed id 16202213)1, 9 Mukhopadhyay N.K....Jaklitsch M.T. (J. Cell. Mol. Med. 2005)
    205. Upregulation of human telomerase reverse transcriptase mRNA expression by in vitro transfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cells. (PubMed id 16237755)1, 9 Qu Z.L....Zhou Z.L. (World J. Gastroenterol. 2005)
    206. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. (PubMed id 15608686)1, 9 Rahman R....Wiman K.G. (Oncogene 2005)
    207. Transcript regulation of human telomerase reverse transcriptase by c-myc and mad1. (PubMed id 15645079)1, 9 Zou L....Tu Z.G. (Acta Biochim. Biophys. Sin. (Shanghai) 2005)
    208. Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer. (PubMed id 15900578)1, 9 Weikert S....MA1ller M. (Int. J. Cancer 2005)
    209. Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. (PubMed id 16344462)1, 9 Horikawa I....Barrett J.C. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    210. The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas. (PubMed id 16398404)1, 9 Ribeiro-Silva A....Zucoloto S. (Int. J. Biol. Markers 2005)
    211. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. (PubMed id 15843522)1, 9 Kawauchi K....Yamada O. (J. Immunol. 2005)
    212. Serum human telomerase reverse transcriptase messenger RNA as a novel tumor marker for hepatocellular carcinoma. (PubMed id 15867214)1, 9 Miura N....Shiota G. (Clin. Cancer Res. 2005)
    213. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. (PubMed id 16247010)2, 9 Armanios M....Greider C.W. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    214. C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter. (PubMed id 16234237)1, 9 Racek T....PA1tzer B.M. (J. Biol. Chem. 2005)
    215. Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells. (PubMed id 15781646)1, 9 Dalerba P....Castelli C. (Cancer Res. 2005)
    216. Bisphenol A from dental polycarbonate crown upregulates the expression of hTERT. (PubMed id 15368248)1, 9 Takahashi A....Sano H. (J. Biomed. Mater. Res. Part B Appl. Biomater. 2004)
    217. Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. (PubMed id 15381700)1, 9 Banik S.S.R. and Counter C.M. (J. Biol. Chem. 2004)
    218. [Proliferation and hTERT expression in neuroblastoma]. (PubMed id 15168079)1, 9 Krams M....Harms D. (Pathologe 2004)
    219. Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer. (PubMed id 15099954)1, 9 Widschwendter A....Widschwendter M. (Gynecol. Oncol. 2004)
    220. In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. (PubMed id 15202008)1, 9 Amarnath S.M....Greenman J. (Int. J. Oncol. 2004)
    221. Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. (PubMed id 14991929)1, 9 Chen C.J....Harn H.J. (World J. Gastroenterol. 2004)
    222. On the road to immortality: hTERT upregulation in cancer cells. (PubMed id 15094035)1, 9 Janknecht R. (FEBS Lett. 2004)
    223. p53-dependent down-regulation of telomerase is mediated by p21waf1. (PubMed id 15371422)1, 9 Shats I....Rotter V. (J. Biol. Chem. 2004)
    224. [The study on the correlation between telomerase and histopathologic features of retinoblastoma]. (PubMed id 15268829)1, 9 Ren R.J....Chen C.X. (Zhonghua Yan Ke Za Zhi 2004)
    225. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. (PubMed id 15367601)1, 9 Verma S.C....Robertson E.S. (J. Virol. 2004)
    226. Glioblastoma induces vascular endothelial cells to express telomerase in vitro. (PubMed id 12839970)1, 9 Falchetti M.L....Pallini R. (Cancer Res. 2003)
    227. Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker. (PubMed id 12893365)1, 9 Melissourgos N....Lykourinas M. (Urology 2003)
    228. Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line. (PubMed id 12917431)1, 9 Kawagoe J....Kurachi H. (J. Biol. Chem. 2003)
    229. Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. (PubMed id 12839932)1, 9 Folini M....Zaffaroni N. (Cancer Res. 2003)
    230. Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell line. (PubMed id 14646192)1, 9 Song J.S....Kim Y.T. (Biosci. Biotechnol. Biochem. 2003)
    231. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. (PubMed id 12970752)1, 9 Goueli B.S. and Janknecht R. (Oncogene 2003)
    232. Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome. (PubMed id 12629597)1, 9 Zhang A....Xu D. (Am. J. Hum. Genet. 2003)
    233. The diagnostic and prognostic relevance of human telomerase reverse transcriptase mRNA expression detected in situ in patients with nonsmall cell lung carcinoma. (PubMed id 12942569)1, 9 Fujita Y....Kikuchi K. (Cancer 2003)
    234. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. (PubMed id 12821782)1, 9 Veldman T....Schlegel R. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    235. Regulation of telomerase activity in Jurkat T cells by transcription factors Sp1 and Sp3. (PubMed id 12297462)1, 9 Pang J.X....Wu S.G. (Di Yi Jun Yi Da Xue Xue Bao 2002)
    236. [Inhibition of telomerase activity and induction of apoptosis in lung cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide]. (PubMed id 11940318)1, 9 Wang X....Xiong W. (Zhonghua Nei Ke Za Zhi 2002)
    237. Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells. (PubMed id 12368233)1, 9 Won J....Kim T.K. (FASEB J. 2002)
    238. Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells. (PubMed id 12218171)1, 9 Hernandez J....Zanetti M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    239. Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. (PubMed id 12007187)1, 9 Zhang A....Xu D. (amp 2002)
    240. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. (PubMed id 12447689)1, 9 Delhommeau F....Bennaceur-Griscelli A. (Oncogene 2002)
    241. Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. (PubMed id 12151407)1, 9 Won J....Kim T.K. (J. Biol. Chem. 2002)
    242. Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system. (PubMed id 12439749)1, 9 Kirch H.C....Hengge U.R. (Oncogene 2002)
    243. p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma. (PubMed id 12496479)1, 9 Sood A.K....Klingelhutz A. (amp 2002)
    244. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. (PubMed id 9973199)1, 9 Takakura M....Inoue M. (Cancer Res. 1999)
    245. Telomerase is controlled by protein kinase Calpha in human breast cancer cells. (PubMed id 9837921)1, 9 Li H....Liu J.P. (J. Biol. Chem. 1998)
    246. An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. (PubMed id 24216762)1 Listerman I....Blackburn E.H. (Mol. Cell. Biol. 2014)
    247. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. (PubMed id 23766237)1 Liu X....Xing M. (Endocr. Relat. Cancer 2013)
    248. An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes. (PubMed id 24074563)1 Xu M....Galloway D.A. (Virology 2013)
    249. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    250. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. (PubMed id 23598174)1 Castelo-Branco P....Tabori U. (Lancet Oncol. 2013)
    251. Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme. (PubMed id 23551398)1 Hukezalie K.R. and Wong J.M. (FEBS J. 2013)
    252. RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population. (PubMed id 23812731)1 Jin T.B....Li S.Q. (Tumour Biol. 2013)
    253. Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia. (PubMed id 23548418)1 Palma M....Mellstedt H. (Exp. Hematol. 2013)
    254. Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-I_B-dependent transcription. (PubMed id 23884427)1 Ding D....Cong Y.S. (FASEB J. 2013)
    255. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. (PubMed id 23530248)1 Killela P.J....Yan H. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    256. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. (PubMed id 23535733)1 Garcia-Closas M....Kraft P. (Nat. Genet. 2013)
    257. TERT's role in colorectal carcinogenesis. (PubMed id 22351525)1 Pellatt A.J....Slattery M.L. (Mol. Carcinog. 2013)
    258. Telomerase and telomere length in pulmonary fibrosis. (PubMed id 23526226)1 Liu T....Phan S.H. (Am. J. Respir. Cell Mol. Biol. 2013)
    259. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. (PubMed id 23287597)1 Comandini A....Franzese O. (Mol. Immunol. 2013)
    260. Regulation of telomerase alternative splicing: a target for chemotherapy. (PubMed id 23562158)1 Wong M.S....Wright W.E. (Cell Rep 2013)
    261. Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome. (PubMed id 22948024)1 Bellido F....Valle L. (Eur. J. Hum. Genet. 2013)
    262. Overexpression of hTERT in potentially malignant colorectal laterally spreading tumors. (PubMed id 23525166)1 Li J....Han Y.J. (Mol Med Rep 2013)
    263. Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis. (PubMed id 23707794)1 Li C....Zhou B. (Gene 2013)
    264. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. (PubMed id 23447707)1 D'Souza Y....Autexier C. (Mol. Biol. Cell 2013)
    265. TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. (PubMed id 24101484)1 Rachakonda P.S....Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    266. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. (PubMed id 23535824)1 Kote-Jarai Z....Eeles R.A. (Hum. Mol. Genet. 2013)
    267. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. (PubMed id 23887712)1 Nault J.C....Zucman Rossi J. (Nat Commun 2013)
    268. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. (PubMed id 23583980)1 Fingerlin T.E....Schwartz D.A. (Nat. Genet. 2013)
    269. Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population. (PubMed id 23433592)1 Myneni A.A....Mu L. (Lung Cancer 2013)
    270. Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. (PubMed id 23833040)1 Landa I....Fagin J.A. (J. Clin. Endocrinol. Metab. 2013)
    271. Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. (PubMed id 23432846)1 Wang L....Yin Y.C. (Diagn Pathol 2013)
    272. Differences in the expression of telomerase and prostate-specific membrane antigen in non-advanced prostatic cancer. (PubMed id 23690220)1 Gasinska A....Cichocka A. (Folia Histochem. Cytobiol. 2013)
    273. A family with Hoyeraal-Hreidarsson syndrome and four variants in two genes of the telomerase core complex. (PubMed id 23335200)1 Vogiatzi P....Bessler M. (amp 2013)
    274. hTERT extends the life of human fibroblasts without compromising type I interferon signaling. (PubMed id 23472163)1 Smith M.C....Davido D.J. (PLoS ONE 2013)
    275. Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects. (PubMed id 22893025)1 Yang X....Liu Y. (Arch. Dermatol. Res. 2013)
    276. The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population. (PubMed id 23359026)1 Wang H....Ma Z. (Genet. Mol. Res. 2013)
    277. Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. (PubMed id 23603989)1 Liu X....Xing M. (Cell Cycle 2013)
    278. Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. (PubMed id 22765508)1 Liu T.M....Lim B. (Stem Cells Dev. 2013)
    279. miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo. (PubMed id 23562653)1 Chakrabarti M....Ray S.K. (Exp. Cell Res. 2013)
    280. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. (PubMed id 23555636)1 Lan Q....Rothman N. (PLoS ONE 2013)
    281. Insights into diseases of human telomerase from dynamical modeling. (PubMed id 23424125)1 Flores S.C....Waldsich C. (Pac Symp Biocomput 2013)
    282. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. (PubMed id 23624506)1 Yang Y.L....Chen C.S. (Biochem. Biophys. Res. Commun. 2013)
    283. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. (PubMed id 23221128)1 Walsh K.M....Amos C.I. (amp 2013)
    284. Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations. (PubMed id 23901064)1 Du J....Jin G. (Carcinogenesis 2013)
    285. Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. (PubMed id 23368278)1 Zhao Z....Lu D. (Exp. Lung Res. 2013)
    286. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. (PubMed id 23666240)1 Ruark E....Turnbull C. (Nat. Genet. 2013)
    287. Telomerase activity and telomere length distribution in vascular endothelial cells in a short-term culture under the presence of hydrogen peroxide. (PubMed id 22985061)1 Maeda T....Makino N. (amp 2013)
    288. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. (PubMed id 23764841)1 Arita H....Ichimura K. (Acta Neuropathol. 2013)
    289. The TERT MNS16A polymorphism contributes to cancer susceptibility: meta-analysis of the current studies. (PubMed id 23462332)1 Chen P....Gu A. (Gene 2013)
    290. TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours. (PubMed id 23799844)1 Griewank K.G....Zeschnigk M. (Br. J. Cancer 2013)
    291. Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus. (PubMed id 23137523)1 Schilling G....Dierlamm J. (Leuk. Res. 2013)
    292. Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes. (PubMed id 23860446)1 WahlstrAPm T....Arsenian Henriksson M. (Exp. Cell Res. 2013)
    293. c-MYC and h-TERT co-expression in colon adenocarcinoma: a tissue microarray digitized image analysis. (PubMed id 23613397)1 Georgakopoulos G....Patsouris E. (J BUON 2013)
    294. Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study. (PubMed id 23629941)1 Pellatt A.J....Slattery M.L. (amp 2013)
    295. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (PubMed id 23535731)1 Bojesen S.E....Dunning A.M. (Nat. Genet. 2013)
    296. Telomerase- and angiogenesis-related gene responses to irradiation in human umbilical vein endothelial cells. (PubMed id 23503666)1 Chang H....Chung H.C. (Int. J. Mol. Med. 2013)
    297. The roles of telomerase in the generation of polyploidy during neoplastic cell growth. (PubMed id 23441130)1 Christodoulidou A....Gagos S. (Neoplasia 2013)
    298. Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. (PubMed id 23908149)1 Zhong R....Miao X. (Mol. Carcinog. 2013)
    299. Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells. (PubMed id 22957790)1 Bashash D....Ghavamzadeh A. (amp 2013)
    300. hTERT rs2736098 genetic variants and susceptibility of hepatocellular carcinoma in the Chinese population: a case-control study. (PubMed id 23392802)1 Zhang C....Ni H. (amp 2013)
    301. Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia. (PubMed id 23641014)1 Miyazaki Y....Yasukawa M. (Blood 2013)
    302. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands. (PubMed id 23603390)1 Zhuang X.Y. and Yao Y.G. (FEBS Lett. 2013)
    303. Telomerase activity in human brain tumors: astrocytoma and meningioma. (PubMed id 23512291)1 Kheirollahi M....Mehdipour P. (Cell. Mol. Neurobiol. 2013)
    304. ES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activity. (PubMed id 23326460)1 Liu Z....Wang Z. (PLoS ONE 2013)
    305. HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. (PubMed id 23592995)1 Miller J....Liu X. (PLoS Pathog. 2013)
    306. Methylation of the hTERT promoter: a novel cancer biomarker for leptomeningeal metastasis detection in cerebrospinal fluids. (PubMed id 23444211)1 Bougel S....Benhattar J. (Clin. Cancer Res. 2013)
    307. Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. (PubMed id 23585473)1 Winkler T....Calado R.T. (J. Clin. Invest. 2013)
    308. A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. (PubMed id 23538340)1 Gramatges M.M....Bertuch A.A. (Blood 2013)
    309. Effect of newly identified hTERT-interacting proteins on telomerase activity. (PubMed id 23709204)1 Zhou L....Qiu K. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)
    310. Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells. (PubMed id 23850566)1 Akiyama M....Yamada H. (Cancer Lett. 2013)
    311. Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in Chinese women nonsmokers. (PubMed id 23738012)1 Li C....Zhou B. (PLoS ONE 2013)
    312. The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy. (PubMed id 23562826)1 Concetti F....Napolioni V. (Exp. Gerontol. 2013)
    313. Pulmonary alveolar proteinosis revealing a telomerase disease. (PubMed id 23905534)1 Marchand-Adam S....Diot P. (Am. J. Respir. Crit. Care Med. 2013)
    314. Frequency of TERT promoter mutations in human cancers. (PubMed id 23887589)1 Vinagre J....Soares P. (Nat Commun 2013)
    315. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. (PubMed id 23326372)1 Singhapol C....Saretzki G.C. (PLoS ONE 2013)
    316. hTERT inhibition triggers Epstein-Barr virus lytic cycle and apoptosis in immortalized and transformed B cells: a basis for new therapies. (PubMed id 23444223)1 Giunco S....De Rossi A. (Clin. Cancer Res. 2013)
    317. Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer. (PubMed id 23527617)1 Ding D....Cong Y.S. (FEBS J. 2013)
    318. [Tert promoter mutations in melanoma: not only the MAP-kinase pathway]. (PubMed id 23773757)1 Dereure O. (Ann Dermatol Venereol 2013)
    319. Inter-telomeric recombination is present in telomerase-positive human cells. (PubMed id 23759591)1 Dlaska M....Bechter O.E. (Cell Cycle 2013)
    320. Role of selected genetic variants in lung cancer risk in African Americans. (PubMed id 23454887)1 Spitz M.R....Schwartz A.G. (J Thorac Oncol 2013)
    321. Telomerase mRNA detection in serum of patients with prostate cancer. (PubMed id 21353795)1 Dalle Carbonare L....Valenti M.T. (Urol. Oncol. 2013)
    322. Telomeres and chromosomal instability in chronic lymphocytic leukemia. (PubMed id 22878603)1 VAcronA"se L....Tchirkov A. (Leukemia 2013)
    323. Serine/threonine-protein phosphatase 2A physically interacts with human telomerase reverse transcriptase hTERT and regulates its subcellular distribution. (PubMed id 22961627)1 Xi P....Cong Y.S. (J. Cell. Biochem. 2013)
    324. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. (PubMed id 23045275)1 Liu Z....Xu D. (Oncogene 2013)
    325. Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner. (PubMed id 23677713)1 Rubis B....Rybczynska M. (Mol. Biol. Rep. 2013)
    326. Highly recurrent TERT promoter mutations in human melanoma. (PubMed id 23348506)1 Huang F.W....Garraway L.A. (Science 2013)
    327. The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. (PubMed id 23610451)1 Listerman I....Blackburn E.H. (Cancer Res. 2013)
    328. Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer. (PubMed id 22527847)1 Kang Y....Shang J. (Int. J. Clin. Oncol. 2013)
    329. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. (PubMed id 23741361)1 Wang W....Zhou Y. (PLoS ONE 2013)
    330. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. (PubMed id 23303810)7 Leeansyah E....Lewin S.R. (J. Infect. Dis. 2013)
    331. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. (PubMed id 23901009)1 Zaug A.J....Cech T.R. (Nucleic Acids Res. 2013)
    332. Alternative lengthening of telomeres is induced by telomerase inhibitors in Barrett's esophageal cells. (PubMed id 23338150)1 Qin X....Zhao B. (Oncol. Rep. 2013)
    333. Hypomethylated CpG around the transcription start site enables TERT expression and HPV16 E6 regulates TERT methylation in cervical cancer cells. (PubMed id 22108635)1 Jiang J....Wei L.H. (Gynecol. Oncol. 2012)
    334. Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death. (PubMed id 22517724)1 Pettigrew K.A....Mills K.I. (amp 2012)
    335. MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth. (PubMed id 22709411)1 Wang Y.Y....You Y.P. (amp 2012)
    336. hTERT cancer risk genotypes are associated with telomere length. (PubMed id 22539396)1 Melin B.S....Roos G. (Genet. Epidemiol. 2012)
    337. Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-I+ without affecting NF-I_B activation. (PubMed id 22108091)1 Mattiussi M....Decottignies A. (Cell. Signal. 2012)
    338. Accuracy of telomerase in estimating breast cancer risk: a systematic review and meta-analysis. (PubMed id 21911295)1 Winnikow E.P....Rosa M.I. (Breast 2012)
    339. Combined analysis of TMPRSS2-ERG and TERT for improved prognosis of biochemical recurrence in prostate cancer. (PubMed id 22505341)1 Sabaliauskaite R....Lazutka J.R. (amp 2012)
    340. hTERT-siRNA could potentiate the cytotoxic effect of gemcitabine to pancreatic cancer cells Bxpc-3. (PubMed id 22757972)1 Tan J....Zhu H. (Exp Clin Transplant 2012)
    341. Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk. (PubMed id 22267287)1 Terry K.L....Cramer D.W. (amp 2012)
    342. Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. (PubMed id 22907755)1 HrdlickovA! R....Bose H.R. (Mol. Cell. Biol. 2012)
    343. MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene. (PubMed id 22240313)1 Shi L....Su B. (Gene 2012)
    344. The human CST complex is a terminator of telomerase activity. (PubMed id 22763445)1 Chen L.Y....Lingner J. (Nature 2012)
    345. Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer. (PubMed id 23107094)1 Liu H....Zhang Y. (Diagn Pathol 2012)
    346. HTERT MNS16A polymorphism in breast cancer: a case-control study. (PubMed id 23065203)1 Zagouri F....Papadimitriou C.A. (Mol. Biol. Rep. 2012)
    347. Inducible immortality in hTERT-human mesenchymal stem cells. (PubMed id 22674533)1 Piper S.L....Kim H.T. (J. Orthop. Res. 2012)
    348. PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells. (PubMed id 22316341)1 Lai X.F....Wang H.L. (amp 2012)
    349. The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita. (PubMed id 22058290)1 Zeng X.L....Wong J.M. (Hum. Mol. Genet. 2012)
    350. Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells. (PubMed id 22750441)1 Eitsuka T....Miyazawa T. (FEBS Lett. 2012)
    351. TERT rs2736098 polymorphism and cancer risk: results of a meta-analysis. (PubMed id 22994782)1 Qi H.Y....Gu A.H. (Asian Pac. J. Cancer Prev. 2012)
    352. Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/I^-catenin pathway in human cancer. (PubMed id 22854964)1 Zhang Y....Wang X. (J. Biol. Chem. 2012)
    353. Telomerase reverse transcriptase (TERT) is a therapeutic target of oleanane triterpenoid CDDO-Me in prostate cancer. (PubMed id 23519253)1 Liu Y....Gautam S.C. (Molecules 2012)
    354. hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms. (PubMed id 22364217)1 Tsang A.R....Beattie T.L. (Aging Cell 2012)
    355. Predictive role of telomerase activity in the clinical outcome of patients with benign lesions of the uterine cervix or CIN. (PubMed id 22596181)1 Bravaccini S....Silvestrini R. (Anal Cell Pathol (Amst) 2012)
    356. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. (PubMed id 21937513)1 Sharma N.K....Santos J.H. (Nucleic Acids Res. 2012)
    357. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    358. Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study. (PubMed id 22178426)1 Kroenke C.H....Epel E. (Atherosclerosis 2012)
    359. Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry. (PubMed id 22134622)1 Zheng Y....Huo D. (Breast Cancer Res. Treat. 2012)
    360. Association of TERT rs2736098 polymorphism with cancer risk: a meta-analysis. (PubMed id 23244087)1 Zhang X.J....Chen J.F. (Asian Pac. J. Cancer Prev. 2012)
    361. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. (PubMed id 21796628)1 Eijsink J.J....Wisman G.B. (Int. J. Cancer 2012)
    362. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PubMed id 23284306)1 Xie L....Green M.R. (PLoS Genet. 2012)
    363. The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. (PubMed id 22221621)1 Zou P....Lu A. (BMC Cancer 2012)
    364. hTERT gene amplification and clinical significance in pleural effusions of patients with lung cancer. (PubMed id 22464057)1 Cha N....Wu G.P. (Clin Lung Cancer 2012)
    365. PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization. (PubMed id 22749911)1 Cheung D.H....Shaw P.C. (FEBS Lett. 2012)
    366. Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells. (PubMed id 21743490)1 Fleisig H.B. and Wong J.M. (Oncogene 2012)
    367. TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. (PubMed id 23226346)1 Yin J....Wei S. (PLoS ONE 2012)
    368. Quantification of alternative splicing variants of human telomerase reverse transcriptase and correlations with telomerase activity in lung cancer. (PubMed id 22723897)1 Liu Y....Fang W.G. (PLoS ONE 2012)
    369. The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. (PubMed id 22226966)1 Her J. and Chung I.K. (Biochem. Biophys. Res. Commun. 2012)
    370. Specificity requirements for human telomere protein interaction with telomerase holoenzyme. (PubMed id 22893708)1 Sexton A.N....Collins K. (J. Biol. Chem. 2012)
    371. Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese. (PubMed id 22795327)1 Li G....Gao G.D. (Cancer Epidemiol 2012)
    372. Loss of the malignant phenotype of human neuroblastoma cells by a catalytically inactive dominant-negative hTERT mutant. (PubMed id 22933702)1 Samy M....SAcgal-Bendirdjian E. (Mol. Cancer Ther. 2012)
    373. Association between hTERT activation by HPV E6 proteins and oncogenic risk. (PubMed id 22925336)1 Van Doorslaer K. and Burk R.D. (Virology 2012)
    374. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. (PubMed id 22863003)1 Zhong F.L....Artandi S.E. (Cell 2012)
    375. Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk. (PubMed id 21993562)1 Law M.H....MacGregor S. (J. Invest. Dermatol. 2012)
    376. High resolution melting analysis for the identification of novel mutations in DKC1 and TERT genes in patients with dyskeratosis congenita. (PubMed id 22664374)1 Carrillo J....Perona R. (amp 2012)
    377. The hTERT promoter enhances the antitumor activity of an oncolytic adenovirus under a hypoxic microenvironment. (PubMed id 22720091)1 Hashimoto Y....Fujiwara T. (PLoS ONE 2012)
    378. Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity. (PubMed id 22872929)1 Xin T....Jin X.M. (Br. J. Biomed. Sci. 2012)
    379. Telomeres and tissue engineering: the potential roles of TERT in VEGF-mediated angiogenesis. (PubMed id 23065534)1 Hartwig F.P....Demarco F.F. (Stem Cell Rev 2012)
    380. Telomerase recruitment requires both TCAB1 and Cajal bodies independently. (PubMed id 22547674)1 Stern J.L....Bryan T.M. (Mol. Cell. Biol. 2012)
    381. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. (PubMed id 23143601)1 Lan Q....Rothman N. (Nat. Genet. 2012)
    382. InTERTesting association between telomerase, mTOR and phytochemicals. (PubMed id 22455872)1 Sundin T. and Hentosh P. (Expert Rev Mol Med 2012)
    383. Cell-free circulating plasma hTERT mRNA is a useful marker for prostate cancer diagnosis and is associated with poor prognosis tumor characteristics. (PubMed id 22916267)1 March-Villalba J.A....DasA- F. (PLoS ONE 2012)
    384. Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. (PubMed id 23284695)1 Schmedt T....Jurkunas U.V. (PLoS ONE 2012)
    385. Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas. (PubMed id 22243975)1 Matsuo T....Ochi M. (amp 2012)
    386. Expression of human telomerase reverse transcriptase in vulvar intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study with survivin and p53. (PubMed id 23106581)1 Wellenhofer A. and Brustmann H. (amp 2012)
    387. [Expressions of B-cell-specific monoclonal leukemia virus insert site 1 and human telomerase reverse transcriptase genes in CD34+ cells during ex vivo expansion process]. (PubMed id 23057360)1 Ge J....Tan W. (Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2012)
    388. Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (PubMed id 23258901)1 Churpek J.E....Godley L.A. (Blood 2012)
    389. Prevalence and pathogenesis of Barrett's esophagus in Luoyang, China. (PubMed id 22901192)1 Zhang R.G....Gao C.F. (Asian Pac. J. Cancer Prev. 2012)
    390. Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population. (PubMed id 22228261)1 Wang S....Hu Z. (Mol. Carcinog. 2012)
    391. HIV-1 induces telomerase activity in monocyte-derived macrophages, possibly safeguarding one of its reservoirs. (PubMed id 22787205)1 Reynoso R....Quarleri J. (J. Virol. 2012)
    392. Synchronous cryptogenic liver cirrhosis and idiopathic pulmonary fibrosis: a clue to telomere involvement. (PubMed id 23045155)1 Carulli L....Nascimbeni F. (Hepatology 2012)
    393. Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. (PubMed id 22661914)1 Aubert G....Lansdorp P.M. (PLoS Genet. 2012)
    394. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene. (PubMed id 22197555)1 Yamashita S....Katakura Y. (Biochem. Biophys. Res. Commun. 2012)
    395. Functional haplotypes of the hTERT gene, leukocyte telomere length shortening, and the risk of peripheral arterial disease. (PubMed id 23082138)1 Zhang W....Hui R. (PLoS ONE 2012)
    396. Wnt/I^-catenin signaling regulates telomerase in stem cells and cancer cells. (PubMed id 22723415)1 Hoffmeyer K....Kemler R. (Science 2012)
    397. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. (PubMed id 22797724)1 Shiraishi K....Kohno T. (Nat. Genet. 2012)
    398. Genome-wide association study of glioma and meta-analysis. (PubMed id 22886559)1 Rajaraman P....Chanock S.J. (Hum. Genet. 2012)
    399. Role for telomerase in Listeria monocytogenes infection. (PubMed id 23006849)1 Samba-Louaka A....Cossart P. (Infect. Immun. 2012)
    400. Therapeutic efficacy of an hTERT promoter-driven oncolytic adenovirus that expresses apoptin in gastric carcinoma. (PubMed id 22842823)1 Liu L....Chi B. (Int. J. Mol. Med. 2012)
    401. Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance. (PubMed id 22516689)1 Venturini L....Zaffaroni N. (Neuro-oncology 2012)
    402. Plasma hTERT mRNA discriminates between clinically localized and locally advanced disease and is a predictor of recurrence in prostate cancer patients. (PubMed id 22559196)1 March-Villalba J.A....DasA- F. (Expert Opin Biol Ther 2012)
    403. Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk. (PubMed id 22495810)1 Hofer P....Gsur A. (Mol. Carcinog. 2012)
    404. [Effects of AZT on leukemia cell line KG-1a proliferation and telomerase activity]. (PubMed id 22541081)1 Jin R.R....Zhang H. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2012)
    405. Effective antitumor immunity against murine gliomas using dendritic cells transduced with hTERTC27 recombinant adenovirus. (PubMed id 22210010)1 Gong H.X....Peng Y. (Oncol. Rep. 2012)
    406. [Leptin promotes the expression of hTERT via STAT3 in breast cancer cells]. (PubMed id 23158658)1 Li S.S....Hao J.H. (Zhonghua Yi Xue Za Zhi 2012)
    407. Human telomerase reverse transcriptase (hTERT) is a target gene of I^-catenin in human colorectal tumors. (PubMed id 22894902)1 Jaitner S....Jung A. (Cell Cycle 2012)
    408. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. (PubMed id 23055531)1 Kasiappan R....Bai W. (J. Biol. Chem. 2012)
    409. Kinetics of DNA replication and telomerase reaction at a single-seeded telomere in human cells. (PubMed id 22353550)1 Hirai Y....Ishikawa F. (amp 2012)
    410. Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases. (PubMed id 22253524)1 Leelawat K....Ratanashu-ek T. (World J. Gastroenterol. 2012)
    411. Predictors of outcome in an AIEOP series of childhood ependymomas: a multifactorial analysis. (PubMed id 23076205)1 Modena P....Massimino M. (Neuro-oncology 2012)
    412. Exclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptases. (PubMed id 23110161)1 Withers J.B....Beemon K.L. (PLoS ONE 2012)
    413. The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. (PubMed id 22902867)1 Sundin T....Hentosh P. (Biochimie 2012)
    414. Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential. (PubMed id 22472071)1 Sato M....Mochida J. (BMC Musculoskelet Disord 2012)
    415. hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions. (PubMed id 22768805)1 Silva T.C....Burbano R.R. (BMC Gastroenterol 2012)
    416. Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. (PubMed id 22370939)1 Chen X.F....Wang X.B. (Genet. Mol. Res. 2012)
    417. MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer. (PubMed id 21422235)1 Hofer P....Gsur A. (Carcinogenesis 2011)
    418. Simultaneous over activation of EGFR, telomerase (h TERT), and cyclin D1 correlates with advanced disease in larynx squamous cell carcinoma: a tissue microarray analysis. (PubMed id 20373052)1 Chrysovergis A....Kyroudi A. (Med. Oncol. 2011)
    419. [hTERT single nucleotide polymorphism is associated with increased risks of hepatocellular carcinoma and tumor metastasis]. (PubMed id 21269955)1 Dong J....Liu H.Y. (Nan Fang Yi Ke Da Xue Xue Bao 2011)
    420. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. (PubMed id 21119197)1 Soohoo C.Y....Zhou X.Z. (J. Biol. Chem. 2011)
    421. Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. (PubMed id 21453684)1 Liu X....Pan C. (Biochem. Pharmacol. 2011)
    422. Direct involvement of the TEN domain at the active site of human telomerase. (PubMed id 21051362)1 Jurczyluk J....Bryan T.M. (Nucleic Acids Res. 2011)
    423. Quantitative methylation analysis of BCL2, hTERT, and DAPK promoters in urine sediment for the detection of non-muscle-invasive urothelial carcinoma of the bladder: a prospective, two-center validation study. (PubMed id 19272801)1 Vinci S....Orlando C. (Urol. Oncol. 2011)
    424. Telomerase reverse transcriptase catalytic subunit expression and proliferation index in Wilms tumor. (PubMed id 21553236)1 Diniz G....Vergin C. (Tumour Biol. 2011)
    425. Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability. (PubMed id 22152854)1 Ueda Y....Sueda T. (J. Pediatr. Surg. 2011)
    426. Tubal metaplasia of the endometrium with cytologic atypia: analysis of p53, Ki-67, TERT, and long-term follow-up. (PubMed id 21572399)1 Simon R.A....Sung C.J. (Mod. Pathol. 2011)
    427. Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. (PubMed id 21606328)1 Steczkiewicz K....Ginalski K. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    428. Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. (PubMed id 21730156)1 Okamoto N....Masutomi K. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    429. Mapping the FEN1 interaction domain with hTERT. (PubMed id 21345332)1 Sampathi S. and Chai W. (Biochem. Biophys. Res. Commun. 2011)
    430. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression. (PubMed id 21193962)1 Beck S....Kim H. (Mol. Cells 2011)
    431. A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population. (PubMed id 21929825)1 Zhang Y....Zhou G. (BMC Med 2011)
    432. Circulating DNA is a useful prognostic factor in patients with advanced non-small cell lung cancer. (PubMed id 21252717)1 Sirera R....Camps C. (J Thorac Oncol 2011)
    433. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. (PubMed id 22037553)1 Haiman C.A....Couch F.J. (Nat. Genet. 2011)
    434. [Correlation of CD82 and hTERT expressions and HPV infection with penile cancer]. (PubMed id 21961244)1 Zhai J.P....Xu K.X. (Zhonghua Nan Ke Xue 2011)
    435. Pancreatic cancer susceptibility loci and their role in survival. (PubMed id 22125638)1 Rizzato C....Canzian F. (PLoS ONE 2011)
    436. [The relationship between gene polymorphism of telomerase reverse transcriptase and susceptibility to hepatocellular carcinoma]. (PubMed id 22041560)1 Ding C.Y....Shen H.B. (Zhonghua Yu Fang Yi Xue Za Zhi 2011)
    437. Telomere length in myelodysplastic syndromes. (PubMed id 21635204)1 Rollison D.E....List A.F. (amp 2011)
    438. EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. (PubMed id 21156006)1 Heeg S....Opitz O.G. (Cancer Sci. 2011)
    439. Recombinant adenovirus-mediated human telomerase reverse transcriptase gene can stimulate cell proliferation and maintain primitive characteristics in bovine mammary gland epithelial cells. (PubMed id 21447096)1 He X.Y....Zhang Y. (amp 2011)
    440. Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. (PubMed id 21771723)1 Pande M....Amos C.I. (Carcinogenesis 2011)
    441. The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps. (PubMed id 21804459)1 Hu J. and Yuan R. (Med. Sci. Monit. 2011)
    442. Differences in disease severity but similar telomere lengths in genetic subgroups of patients with telomerase and shelterin mutations. (PubMed id 21931702)1 Vulliamy T.J....Dokal I. (PLoS ONE 2011)
    443. Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme. (PubMed id 21332924)1 Alfred T....Day I.N. (Aging Cell 2011)
    444. hTERT regulation by NF-I_B and c-myc in irradiated HER2-positive breast cancer cells. (PubMed id 21627565)1 Papanikolaou V....Tsezou A. (Int. J. Radiat. Biol. 2011)
    445. The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate. (PubMed id 21936563)1 Soares J....Jarstfer M.B. (Biochemistry 2011)
    446. Genome-wide association study identifies three new melanoma susceptibility loci. (PubMed id 21983787)1 Barrett J.H....Bishop D.T. (Nat. Genet. 2011)
    447. Characterization and comparison of telomere length, telomerase and reverse transcriptase activity and gene expression in human mesenchymal stem cells and cancer cells of various origins. (PubMed id 21638208)1 Jeon B.G....Rho G.J. (Cell Tissue Res. 2011)
    448. Telomerase and the endocrine system. (PubMed id 21448143)1 Pacini F....Marchisotta S. (Nat Rev Endocrinol 2011)
    449. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. (PubMed id 21549308)1 Zhao Y....Wright W.E. (Mol. Cell 2011)
    450. [Prognostic significance of hTERT mRNA quantitative expression in resected gastric carcinomas]. (PubMed id 21575461)1 Qiu D....Zhou J.J. (Zhonghua Zhong Liu Za Zhi 2011)
    451. Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. (PubMed id 21106948)1 Gizard F....Bruemmer D. (Arterioscler. Thromb. Vasc. Biol. 2011)
    452. MMP-9 silencing regulates hTERT expression via I^1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells. (PubMed id 21855630)1 Ponnala S....Rao J.S. (Cell. Signal. 2011)
    453. NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepGa88 hepatoma cell line. (PubMed id 22008847)1 Zuo Q.P....Huang L.H. (Eur. J. Pharmacol. 2011)
    454. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. (PubMed id 21071633)1 Indran I.R....Pervaiz S. (Cancer Res. 2011)
    455. Adenovirus-mediated transfer of tris-shRNAs induced apoptosis of nasopharyngeal carcinoma cell in vitro and in vivo. (PubMed id 21669490)1 Han J.B....Xiao B.K. (Cancer Lett. 2011)
    456. Knockdown of hTERT alters biophysical properties of K562 cells resulting in decreased migration rate in vitro. (PubMed id 21833675)1 Zhang Y....Yao W. (Cell Biochem. Biophys. 2011)
    457. Identification of CD133(-)/telomerase(low) progenitor cells in glioblastoma-derived cancer stem cell lines. (PubMed id 21082235)1 Beier F....Beier D. (Cell. Mol. Neurobiol. 2011)
    458. A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells. (PubMed id 21411498)1 Meeran S.M....Tollefsbol T.O. (Cancer Prev Res (Phila) 2011)
    459. Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma. (PubMed id 21492065)1 Li J....Duan M. (Acta Otolaryngol. 2011)
    460. Prognostic significance of telomerase activity and some tumor markers in non-small cell lung cancer. (PubMed id 20146105)1 Hashim M....Elshazly S. (Med. Oncol. 2011)
    461. Dynamics of telomere's length and telomerase activity in Philadelphia chromosome negative myeloproliferative neoplasms. (PubMed id 20828816)1 Spanoudakis E....Tsatalas C. (Leuk. Res. 2011)
    462. Separation of telomerase functions by reverse genetics. (PubMed id 21949400)1 Mukherjee S....Roberts J.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    463. Endometriosis: a crosstalk between epidermal growth factor (EGF) gene polymorphism and telomerase activity? (PubMed id 21982438)1 Mormile R. and Vittori G. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2011)
    464. The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. (PubMed id 22011238)1 Sealey D.C....Harrington L. (BMC Mol. Biol. 2011)
    465. hTERT promotes imatinib resistance in chronic myeloid leukemia cells: therapeutic implications. (PubMed id 21364010)1 Deville L....SAcgal-Bendirdjian E. (Mol. Cancer Ther. 2011)
    466. High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. (PubMed id 21536653)1 Li A.Y....Ann D.K. (Mol. Cell. Biol. 2011)
    467. Telomerase gene mutations are associated with cirrhosis formation. (PubMed id 21520174)1 Hartmann D....Rudolph K.L. (Hepatology 2011)
    468. BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells. (PubMed id 20876690)1 Renaud S....Benhattar J. (Nucleic Acids Res. 2011)
    469. Natural history of pulmonary fibrosis in two subjects with the same telomerase mutation. (PubMed id 20966039)1 El-Chemaly S....Gochuico B.R. (Chest 2011)
    470. Evaluation of serum human telomerase reverse transcriptase as a novel marker for cervical cancer. (PubMed id 21319134)1 Porika M....Abbagani S. (Int. J. Biol. Markers 2011)
    471. Telomerase activation without shortening of telomeric 3'-overhang is a poor prognostic factor in human colorectal cancer. (PubMed id 21108695)1 Kojima K....Hiyama K. (Cancer Sci. 2011)
    472. Transcriptional repression by the proximal exonic region at the human TERT gene. (PubMed id 21787851)1 Wong T.C....Drewell R.A. (Gene 2011)
    473. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne Sanjose S. (Haematologica 2011)
    474. Serum human telomerase reverse transcriptase: a novel biomarker for breast cancer diagnosis. (PubMed id 21526393)1 Porika M....Abbagani S. (Int. J. Clin. Oncol. 2011)
    475. Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. (PubMed id 21350045)1 Chen H....Lu D. (Am. J. Epidemiol. 2011)
    476. Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study. (PubMed id 21975338)1 Lee Y.S....Ji Y.B. (amp 2011)
    477. The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema. (PubMed id 21622582)1 Wauters E....Lambrechts D. (Eur. Respir. J. 2011)
    478. Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour. (PubMed id 21617256)1 Kratz C.P....Greene M.H. (J. Med. Genet. 2011)
    479. hTERT promoter methylation and telomere length in childhood acute lymphoblastic leukemia: associations with immunophenotype and cytogenetic subgroup. (PubMed id 21914494)1 BorssAcn M....Roos G. (Exp. Hematol. 2011)
    480. Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. (PubMed id 21949822)1 Beesley J....Chenevix-Trench G. (PLoS ONE 2011)
    481. [Cyclin D1, hTERT expression and telomerase activity in HL-60 and HL-60A cell lines and their significance]. (PubMed id 21867613)1 Huang K.Z....Wu Y.D. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011)
    482. Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. (PubMed id 21514196)1 Robart A.R. and Collins K. (Mol. Cell 2011)
    483. Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation. (PubMed id 21900196)1 Kawano Y....Ritz J. (Blood 2011)
    484. Architecture of human telomerase RNA. (PubMed id 21844345)1 Zhang Q....Feigon J. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    485. Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells. (PubMed id 21590772)1 Liu L....Xu D. (J. Pathol. 2011)
    486. The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. (PubMed id 21447332)1 Sirma H....GA1nes C. (Gastroenterology 2011)
    487. Clinical significance of hTERC and C-Myc genes amplification in a group of Egyptian patients with cancer cervix. (PubMed id 21724525)1 Eid M.M....Abdul Rahman R. (Gulf J Oncolog 2011)
    488. Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. (PubMed id 21300782)1 Qi D.L....Kugoh H. (Mol. Cell. Biol. 2011)
    489. RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer. (PubMed id 21763315)1 Flavin P....Young L.S. (FEBS Lett. 2011)
    490. Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis. (PubMed id 21396644)1 Werner C....Laufs U. (Atherosclerosis 2011)
    491. Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction. (PubMed id 22110753)1 Xue Y....He D. (PLoS ONE 2011)
    492. Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations. (PubMed id 21349926)1 Diaz de Leon A....Garcia C.K. (Chest 2011)
    493. Constitutional telomerase mutations are genetic risk factors for cirrhosis. (PubMed id 21520173)1 Calado R.T....Young N.S. (Hepatology 2011)
    494. Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase. (PubMed id 21940498)1 Kopera H.C....Moran J.V. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    495. Proteomic studies coupled with RNAi methodologies can shed further light on the downstream effects of telomerase in glioma. (PubMed id 21261472)1 Thakkar D....Shervington A. (Cancer Invest. 2011)
    496. Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes. (PubMed id 20938050)1 Chen W....Kang M.K. (J. Biol. Chem. 2010)
    497. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. (PubMed id 20354136)1 Mathew R....Wang S. (FASEB J. 2010)
    498. Association of telomerase activity with radio- and chemosensitivity of neuroblastomas. (PubMed id 20642823)1 Wesbuer S....Greve B. (Radiat Oncol 2010)
    499. KrA1ppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. (PubMed id 20629177)1 Wong C.W....Teng S.C. (Stem Cells 2010)
    500. TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. (PubMed id 20454512)1 Lafferty-Whyte K.... Keith W.N. (Neoplasia 2010)
    501. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay. (PubMed id 20813962)1 Theelen W....Hopman A.H. (Am. J. Pathol. 2010)
    502. CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. (PubMed id 20959453)1 Lee J.H....Chung I.K. (J. Biol. Chem. 2010)
    503. Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT. (PubMed id 20453884)1 Oh W....Song J. (Oncogene 2010)
    504. The human and canine TERT promoters function equivalently in human and canine cells. (PubMed id 21062413)1 Arendt M.L....Morgan I.M. (Vet Comp Oncol 2010)
    505. [Effect of hTERT antisense oligodeoxynucleotide on telomerase activity in bladder cancer cells in vitro]. (PubMed id 20423850)1 Gao X.D. and Chen Y.R. (Nan Fang Yi Ke Da Xue Xue Bao 2010)
    506. TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. (PubMed id 20404094)1 Abreu E....Terns M.P. (Mol. Cell. Biol. 2010)
    507. A novel biomarker TERTmRNA is applicable for early detection of hepatoma. (PubMed id 20482774)1 Miura N....Shiota G. (BMC Gastroenterol 2010)
    508. No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. (PubMed id 20570912)1 Pooley K.A....Dunning A.M. (amp 2010)
    509. Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene. (PubMed id 19432820)1 Kapanadze B....Trojanowska M. (J. Cell. Mol. Med. 2010)
    510. p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. (PubMed id 20569236)1 Bazarov A.V....Yaswen P. (Aging Cell 2010)
    511. Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. (PubMed id 20139322)1 Huang W....Toborek M. (Am. J. Physiol. Heart Circ. Physiol. 2010)
    512. Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines. (PubMed id 20394835)1 George J....Ray S.K. (amp 2010)
    513. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. (PubMed id 20089117)1 Kovalenko O.A....Santos J.H. (Aging Cell 2010)
    514. RNA interference-mediated hTERT inhibition enhances TRAIL-induced apoptosis in resistant hepatocellular carcinoma cells. (PubMed id 20204286)1 Zhang R.G....Fang D.C. (Oncol. Rep. 2010)
    515. Increased placental telomerase mRNA in hypertensive disorders of pregnancy. (PubMed id 20642319)1 Geifman-Holtzman O....Liebermann D.A. (Hypertens Pregnancy 2010)
    516. [Expression of hTERT mRNA in Anip973 and Anip973/NVB cell detected by quantitative real-time PCR]. (PubMed id 20677553)1 Chen G....Liu J. (Zhongguo Fei Ai Za Zhi 2010)
    517. Tumor-targeted efficiency of shRNA vector harboring chimera hTERT/U6 promoter. (PubMed id 20372845)1 Zhang P....Zou L. (Oncol. Rep. 2010)
    518. [Effects of vinorelbine on apoptosis and expression of telomerase activity in human lung adenocarcinoma cells in vitro]. (PubMed id 21163063)1 Liu J.J....Hong X. (Zhonghua Zhong Liu Za Zhi 2010)
    519. Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer. (PubMed id 20509972)1 Li W....Xu D. (Mol. Cancer 2010)
    520. Distinct and temporal roles of nucleosomal remodeling and histone deacetylation in the repression of the hTERT gene. (PubMed id 20053684)1 Wang S....Zhu J. (Mol. Biol. Cell 2010)
    521. Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. (PubMed id 20670406)1 Tsai C.C....Hung S.C. (J. Biomed. Sci. 2010)
    522. Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. (PubMed id 20545697)1 Chen W....Tao Z.Z. (Cancer Sci. 2010)
    523. Study of telomerase reverse transcriptase (hTERT) expression in normal, aged, and photo-aged skin. (PubMed id 21174371)1 Attia E.A....El-Shiemy S.M. (Int. J. Dermatol. 2010)
    524. [Effects of small interference RNA against c-myc on expression of c-myc and h-tert genes in acute lymphoblastic leukemia cell line Jurkat]. (PubMed id 21129250)1 Liu T.B....Hu J.D. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    525. Telomeres and telomerase in normal and malignant B-cells. (PubMed id 20213664)1 Lobetti-Bodoni C....Ladetto M. (Hematol Oncol 2010)
    526. Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells. (PubMed id 20673788)1 Nourbakhsh M....Karami-Tehrani F. (Mol. Cell. Endocrinol. 2010)
    527. Telomerase as an important target of androgen signaling blockade for prostate cancer treatment. (PubMed id 20571066)1 Liu S....Dong Y. (Mol. Cancer Ther. 2010)
    528. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. (PubMed id 19751963)1 Lee J.H. and Chung I.K. (Cancer Lett. 2010)
    529. Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms. (PubMed id 20824134)1 Brennan S.K....Matsui W. (PLoS ONE 2010)
    530. Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts. (PubMed id 21106093)1 Brems-Eskildsen A.S....t L. (BMC Cancer 2010)
    531. The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. (PubMed id 20034955)1 Sealey D.C....Harrington L.A. (Nucleic Acids Res. 2010)
    532. Stromal cell-derived factor 1alpha reduces senescence of endothelial progenitor subpopulation in lectin-binding and DiLDL-uptaking cell through telomerase activation and telomere elongation. (PubMed id 20232301)1 Zheng H....Fu G.S. (J. Cell. Physiol. 2010)
    533. Correlation between morphology and human telomerase gene amplification in bronchial brushing cells for the diagnosis of lung cancer. (PubMed id 19877284)1 Fan Y.B....Wu G.P. (Diagn. Cytopathol. 2010)
    534. Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth. (PubMed id 21042751)1 Xue Y....He D. (Oncol. Rep. 2010)
    535. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. (PubMed id 20019239)1 Li Y....Tollefsbol T.O. (FASEB J. 2010)
    536. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. (PubMed id 20351177)1 Egan E.D. and Collins K. (Mol. Cell. Biol. 2010)
    537. Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. (PubMed id 20456367)1 Waki K....Tahara H. (Cancer Sci. 2010)
    538. RNA conformation in catalytically active human telomerase. (PubMed id 20148555)1 Yeoman J.A....Balasubramanian S. (J. Am. Chem. Soc. 2010)
    539. hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis. (PubMed id 20534141)1 de Wilde J....Steenbergen R.D. (BMC Cancer 2010)
    540. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. (PubMed id 21048121)1 Wang S....Goldman S.A. (J. Neurosci. 2010)
    541. PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells. (PubMed id 20970818)1 Sheng J.F....Tao Z.Z. (amp 2010)
    542. Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients: the European Early Lung Cancer Project. (PubMed id 20596673)1 Van den Berg R.M....Snijders P.J. (Int. J. Oncol. 2010)
    543. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (PubMed id 20101243)1 Petersen G.M....Chanock S.J. (Nat. Genet. 2010)
    544. The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase. (PubMed id 19917726)1 Drosopoulos W.C. and Prasad V.R. (Mol. Cell. Biol. 2010)
    545. Genetic correction of PSA values using sequence variants associated with PSA levels. (PubMed id 21160077)1 Gudmundsson J....Stefansson K. (Sci Transl Med 2010)
    546. Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer. (PubMed id 20920335)1 Mezzasoma L....Mearini E. (BMC Urol 2010)
    547. Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer. (PubMed id 20127252)1 Hu H....Liang X.Q. (J. Cancer Res. Clin. Oncol. 2010)
    548. Irradiation-induced telomerase activity and gastric cancer risk: a case-control analysis in a Chinese Han population. (PubMed id 20565943)1 He X....Bao G. (BMC Cancer 2010)
    549. DNAzyme-like activity of hemin-telomeric G-quadruplexes for the optical analysis of telomerase and its inhibitors. (PubMed id 21031400)1 Freeman R....Willner I. (Chembiochem 2010)
    550. Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures. (PubMed id 20089118)1 Degerman S....Roos G. (Aging Cell 2010)
    551. Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery. (PubMed id 21045143)1 Kuroda S....Fujiwara T. (Cancer Res. 2010)
    552. C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition. (PubMed id 20620128)1 Chen G....Zhao M. (Biochem. Biophys. Res. Commun. 2010)
    553. Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells. (PubMed id 20619302)1 Napier C.E....MacKenzie K.L. (Biochim. Biophys. Acta 2010)
    554. Inducible activation of IFI 16 results in suppression of telomerase activity, growth suppression and induction of cellular senescence. (PubMed id 19885868)1 Clarke C.J....Johnstone R.W. (J. Cell. Biochem. 2010)
    555. Dynamics of telomerase activity in response to acute psychological stress. (PubMed id 20018236)1 Epel E.S....Blackburn E.H. (Brain Behav. Immun. 2010)
    556. Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress. (PubMed id 20520826)1 Kovalenko O.A....Santos J.H. (PLoS ONE 2010)
    557. Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways. (PubMed id 20842112)1 Sitaram R.T....Li A. (Br. J. Cancer 2010)
    558. Telomerase gene mutation screening in Chinese patients with aplastic anemia. (PubMed id 19942288)1 Han B....Zhao Y. (Leuk. Res. 2010)
    559. Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT). (PubMed id 20621064)1 Qi D.L....Kugoh H. (Biochem. Biophys. Res. Commun. 2010)
    560. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. (PubMed id 20052289)1 Song L.L....Choubey D. (PLoS ONE 2010)
    561. Compound heterozygosity for two new TERT mutations in a patient with aplastic anemia. (PubMed id 20658629)1 Aspesi A....Dianzani I. (amp 2010)
    562. A panel of sputum-based genomic marker for early detection of lung cancer. (PubMed id 20864512)1 Jiang F....Stass S.A. (Cancer Prev Res (Phila) 2010)
    563. Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor. (PubMed id 20628269)1 Jin X....Kim H. (amp 2010)
    564. Characterization of an ultra-conserved putative cis-regulatory module at the mammalian telomerase reverse transcriptase gene. (PubMed id 20438356)1 Tran D.A....Drewell R.A. (DNA Cell Biol. 2010)
    565. [Influence on biological characteristics of hepatocytes transfected with hTERT gene by lentivirus]. (PubMed id 20619095)1 Liang X.J....Yang D.H. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010)
    566. Expression of Epstein-Barr virus-encoded LMP1 and hTERT extends the life span and immortalizes primary cultures of nasopharyngeal epithelial cells. (PubMed id 20827769)1 Yip Y.L....Tsao S.W. (J. Med. Virol. 2010)
    567. Telomerase: structure, functions, and activity regulation. (PubMed id 21417995)1 Zvereva M.I....Dontsova O.A. (Biochemistry Mosc. 2010)
    568. Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. (PubMed id 19762557)1 Ge Z....Xu D. (FASEB J. 2010)
    569. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PubMed id 20972438)1 Rothman N....Chanock S.J. (Nat. Genet. 2010)
    570. Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies. (PubMed id 20460502)1 Nagel I....Siebert R. (Blood 2010)
    571. [Effect of valproic acid on apoptosis of leukemia HL-60 cells and expression of h-tert gene]. (PubMed id 21176348)1 Li Y.Q....Wu Y.D. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    572. Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA. (PubMed id 20691751)1 Petrenko A.A....Kisseljov F.L. (Biochimie 2010)
    573. Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. (PubMed id 19360348)1 Moriai M....Watanabe N. (Int. J. Oncol. 2009)
    574. Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1. (PubMed id 19209236)1 Casalbore P....Pallini R. (PLoS ONE 2009)
    575. Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients. (PubMed id 20225759)1 Rha S.Y....Chung H.C. (Oncol. Res. 2009)
    576. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. (PubMed id 19265030)1 Haendeler J....Dimmeler S. (Arterioscler. Thromb. Vasc. Biol. 2009)
    577. Alpha-fetoprotein and human telomerase reverse transcriptase mRNA levels in peripheral blood of patients with hepatocellular carcinoma. (PubMed id 19184104)1 Kong S.Y....Kim C.M. (J. Cancer Res. Clin. Oncol. 2009)
    578. [Telomere length and telomerase expression activity in mononuclear cells of patients with chronic lymphocytic leukemia]. (PubMed id 20030916)1 Ma L....Ke X.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    579. Unusual telomeric DNAs in human telomerase-negative immortalized cells. (PubMed id 19015236)1 Nabetani A. and Ishikawa F. (Mol. Cell. Biol. 2009)
    580. Telomere recombination requires the MUS81 endonuclease. (PubMed id 19363487)1 Zeng S....Yang Q. (Nat. Cell Biol. 2009)
    581. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. (PubMed id 19151717)1 Rafnar T....Stefansson K. (Nat. Genet. 2009)
    582. [Study on telomerase gene mutation in northern Chinese patients with acquired bone marrow failure syndromes.]. (PubMed id 20193600)1 Liu B....Zhao Y.Q. (Zhonghua Xue Ye Xue Za Zhi 2009)
    583. Short telomeres are preferentially elongated by telomerase in human cells. (PubMed id 19716824)1 Britt-Compton B....Baird D.M. (FEBS Lett. 2009)
    584. Telomerase modulates Wnt signalling by association with target gene chromatin. (PubMed id 19571879)2 Park J.I.... Artandi S.E. (Nature 2009)
    585. Induced apoptosis by mild hyperthermia occurs via telomerase inhibition on the three human myeloid leukemia cell lines: TF-1, K562, and HL-60. (PubMed id 19672770)1 Deezagi A....Soheili Z.S. (amp 2009)
    586. Human telomerase gene amplification and high-risk human papillomavirus infection in women with cervical intra-epithelial neoplasia. (PubMed id 19930867)1 Takac I....Kokalj-Vokac N. (J. Int. Med. Res. 2009)
    587. Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity. (PubMed id 19559675)1 Zhou L....Cong Y.S. (Biochem. Biophys. Res. Commun. 2009)
    588. Changes of the alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis. (PubMed id 19188747)1 Xu J.H....Zhang W.M. (Pathobiology 2009)
    589. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    590. Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy. (PubMed id 19342980)1 Nakashima A....Hiyama E. (Pancreas 2009)
    591. Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells. (PubMed id 19560862)1 Moon D.O....Kim G.Y. (Cancer Lett. 2009)
    592. Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. (PubMed id 19843528)1 Chebel A....Ffrench M. (J. Biol. Chem. 2009)
    593. Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice. (PubMed id 19667936)1 Nakahara H....Kobayashi N. (Transplantation 2009)
    594. Telomerase activation by c-Myc in human mammary epithelial cells requires additional genomic changes. (PubMed id 19806010)1 Bazarov A.V....Yaswen P. (Cell Cycle 2009)
    595. [Expression of hTERT and Mad1 in lung cancer in Gejiu and Xuanwei of Yunnan Province]. (PubMed id 19224688)1 Cheng J.L....Zhang L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
    596. Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. (PubMed id 19718948)1 Vageli D....Koukoulis G.K. (Oncol. Res. 2009)
    597. Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus. (PubMed id 19939248)1 Li H....Li Q.H. (amp 2009)
    598. Chromosome end maintenance by telomerase. (PubMed id 19286666)1 Osterhage J.L. and Friedman K.L. (J. Biol. Chem. 2009)
    599. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. (PubMed id 19561322)1 Calado R.T....Young N.S. (Blood 2009)
    600. The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells. (PubMed id 19787269)1 Papanikolaou V....Tsezou A. (Int. J. Oncol. 2009)
    601. A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells. (PubMed id 18997822)1 Li N.F....Balkwill F. (Oncogene 2009)
    602. hTERT promotes the invasion of telomerase-negative tumor cells in vitro. (PubMed id 19578747)1 Yu S.T....Yang S.M. (Int. J. Oncol. 2009)
    603. Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues. (PubMed id 19885561)1 Fabricius E.M....Hoffmeister B. (Int. J. Oncol. 2009)
    604. 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion cases. (PubMed id 19540557)1 Alameda F....Serrano S. (Hum. Pathol. 2009)
    605. Telomerase downregulation in cancer brain stem cell. (PubMed id 19430894)1 Shervington A....Shervington L. (Mol. Cell. Biochem. 2009)
    606. Rearrangement of upstream sequences of the hTERT gene during cellular immortalization. (PubMed id 19672873)1 Zhao Y....Zhu J. (amp 2009)
    607. Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1. (PubMed id 19587703)1 Terme J.M....Jalinot P. (Leukemia 2009)
    608. Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations. (PubMed id 19674077)1 Calado R.T....Young N.S. (Eur. J. Clin. Invest. 2009)
    609. Possible role of telomerase and sFas in pathogenesis of various bladder lesions associated with schistosomiasis. (PubMed id 19272297)1 Shaker O.G....Wishahi M. (Clin. Biochem. 2009)
    610. Ionizing radiation up-regulates telomerase activity in cancer cell lines by post-translational mechanism via ras/phosphatidylinositol 3- kinase/Akt pathway. (PubMed id 19188162)2 Ram R.... Lahav M. (Clin. Cancer Res. 2009)
    611. Effects of hTERT on genomic instability caused by either metal or radiation or combined exposure. (PubMed id 18776173)1 Glaviano A....Lyng F. (Mutagenesis 2009)
    612. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. (PubMed id 19369336)1 Katzenellenbogen R.A....Galloway D.A. (J. Virol. 2009)
    613. HPV E6 protein interacts physically and functionally with the cellular telomerase complex. (PubMed id 19843693)1 Liu X....Schlegel R. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    614. [hTERT gene expression in children with beta-thalassemia major]. (PubMed id 19558808)1 Li X.H....Mu D.Z. (Zhongguo Dang Dai Er Ke Za Zhi 2009)
    615. Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. (PubMed id 19272180)1 Wu Y.H....Wang T.C. (J. Biomed. Sci. 2009)
    616. Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals. (PubMed id 19903097)1 Tichon A....Priel E. (Cytotherapy 2009)
    617. Mechanism of dominant-negative telomerase function. (PubMed id 19738429)1 Nguyen B.N....Holt S.E. (Cell Cycle 2009)
    618. [Expression and significance of hTERT, c-myc and Ki-67 in hepatocellular carcinoma]. (PubMed id 19351506)1 Fang Y.W. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009)
    619. Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. (PubMed id 19900100)1 Patel R.M. and Folpe A.L. (Pathology 2009)
    620. A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. (PubMed id 19740745)1 Woo S.H....Park I.C. (J. Biol. Chem. 2009)
    621. Diagnosis of parathyroid carcinoma using immunohistochemical staining against hTERT. (PubMed id 19885612)1 Osawa N....Hirakawa K. (Int. J. Mol. Med. 2009)
    622. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. (PubMed id 19487455)1 Zhu Q.... Tsai R.Y. (J. Cell Biol. 2009)
    623. Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-beta expression driven by hTERT promoter. (PubMed id 19564073)1 He L.F....Liu X.Y. (Cancer Lett. 2009)
    624. Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression. (PubMed id 19513524)1 Iliopoulos D....Tsezou A. (Oncol. Rep. 2009)
    625. Increase of telomerase activity and hTERT expression in myelodysplastic syndromes. (PubMed id 19270495)1 Briatore F....Ferrero D. (amp 2009)
    626. A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT. (PubMed id 19684619)1 Lafferty-Whyte K....Keith W.N. (Oncogene 2009)
    627. Telomerase insufficiency in rheumatoid arthritis. (PubMed id 19255426)1 Fujii H....Weyand C.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    628. Premature senescence of T lymphocytes from patients with beta-thalassemia major. (PubMed id 19118576)1 Gharagozloo M....Moayedi B. (Immunol. Lett. 2009)
    629. Positive regulation of human telomerase reverse transcriptase gene expression and telomerase activity by DNA methylation in pancreatic cancer. (PubMed id 19194757)1 Kumari A....Wig J.D. (Ann. Surg. Oncol. 2009)
    630. Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. (PubMed id 18021753)1 Patel R....Shervington A. (Brain Res. 2008)
    631. [Expression of human telomerase reverse transcriptase and survivin gene in patients with myelodysplastic syndrome]. (PubMed id 18426652)1 Jiao X.L....Chen W.M. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    632. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. (PubMed id 18717758)1 Zhuang Z.H....Wong B.C. (J. Gastroenterol. Hepatol. 2008)
    633. Physiological assembly and activity of human telomerase complexes. (PubMed id 18054989)1 Collins K. (Mech. Ageing Dev. 2008)
    634. Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. (PubMed id 18644980)1 Chapman E.J....Knowles M.A. (Mol. Cancer Res. 2008)
    635. Differential hTERT mRNA processing between young and older glioma patients. (PubMed id 18435920)1 Shervington A. and Patel R. (FEBS Lett. 2008)
    636. Telomerase activity in transthoracic fine-needle biopsy aspirates from non-small cell lung cancer as prognostic factor of patients' survival. (PubMed id 18063440)1 Targowski T....From S. (Lung Cancer 2008)
    637. Short telomeres, telomerase reverse transcriptase gene amplification, and increased telomerase activity in the blood of familial papillary thyroid cancer patients. (PubMed id 18664542)1 Capezzone M....Pacini F. (J. Clin. Endocrinol. Metab. 2008)
    638. The expression levels of telomerase catalytic subunit hTERT and oncogenic MYC in essential thrombocythemia are affected by the molecular subtype. (PubMed id 18084761)1 Theophile K....Bock O. (Ann. Hematol. 2008)
    639. Immortalization of mesenchymal stem cells from bone marrow of rhesus monkey by transfection with human telomerase reverse transcriptase gene. (PubMed id 18374149)1 Gao K....Cheng J.Q. (Transplant. Proc. 2008)
    640. Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts. (PubMed id 18027853)1 Falchetti M.L....Pallini R. (Int. J. Cancer 2008)
    641. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. (PubMed id 18843043)1 Kudlow B.A....Kennedy B.K. (Mol. Biol. Cell 2008)
    642. Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells. (PubMed id 18511807)1 Bellon M. and Nicot C. (Blood 2008)
    643. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. (PubMed id 18184747)1 Narala S.R....Vaziri H. (Mol. Biol. Cell 2008)
    644. Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. (PubMed id 18584350)1 Parsch D....Fellenberg J. (Cancer Invest. 2008)
    645. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. (PubMed id 18586674)1 Xu D....Liu J.P. (J. Biol. Chem. 2008)
    646. Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma. (PubMed id 18348304)1 Gertler R....Rosenberg R. (Cancer 2008)
    647. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. (PubMed id 18037230)1 Li W....Xu D. (Cancer Lett. 2008)
    648. Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics. (PubMed id 18922974)1 Possemato R....Hahn W.C. (Mol. Cancer Res. 2008)
    649. [Effect of antisense oligodeoxynucleotide targeting hTERT on telomerase activity and cell apoptosis in K562 cell line]. (PubMed id 18315899)1 Ying X.Y....Wang Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    650. [Changes of alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis]. (PubMed id 19079992)1 Xu J.H....Zhang W.M. (Ai Zheng 2008)
    651. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. (PubMed id 18820283)1 Kim R.H....Kang M.K. (Carcinogenesis 2008)
    652. Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. (PubMed id 18059027)1 Bhatia B....Tang D.G. (Int. J. Cancer 2008)
    653. Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. (PubMed id 18201269)1 Mitomo S....Masuda T. (Cancer Sci. 2008)
    654. Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: a high degree of differentiation rather than malignant potential. (PubMed id 18288381)1 Zafrakas M....GA1nes C. (Int. J. Mol. Med. 2008)
    655. Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation. (PubMed id 18616696)1 Huang G.P....Wang J.F. (Cell Prolif. 2008)
    656. hTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells. (PubMed id 18059183)1 Shen Y....Ding J. (amp 2008)
    657. Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells. (PubMed id 18292940)1 Love W.K....Tollefsbol T.O. (Int. J. Oncol. 2008)
    658. TERT promotes cellular and organismal survival independently of telomerase activity. (PubMed id 18223679)1 Lee J....Lee H.W. (Oncogene 2008)
    659. Tumor cell-specific blockade of CXCR4/SDF-1 interactions in prostate cancer cells by hTERT promoter induced CXCR4 knockdown: A possible metastasis preventing and minimizing approach. (PubMed id 18836306)1 Xing Y....Xiao C. (amp 2008)
    660. Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. (PubMed id 17942561)1 Sekaric P....Androphy E.J. (J. Virol. 2008)
    661. Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels. (PubMed id 18451136)1 Cao Y....Reddel R.R. (Cancer Res. 2008)
    662. Cytoplasmic expression of human telomerase catalytic protein (hTERT) in neutrophils: an immunoelectron microscopy study. (PubMed id 18958789)1 Lepreux S....Martin-Negrier M.L. (Ultrastruct Pathol 2008)
    663. Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. (PubMed id 18684838)1 Terrin L....De Rossi A. (J. Virol. 2008)
    664. Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues. (PubMed id 18438345)1 Zhang F....Xin T. (Exp. Oncol. 2008)
    665. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. (PubMed id 18451164)1 Agarwal M....Pandita T.K. (Cancer Res. 2008)
    666. Functional genomics of hTERT gene in leukemic myelopoiesis. (PubMed id 18409031)1 Kaul D....Ahlawat A. (Mol. Cell. Biochem. 2008)
    667. [Plasmid-mediated RNAi targeting hTERT inhibits telomerase activity in K562 cell line]. (PubMed id 18315900)1 Li M.F....Wang Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    668. Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. (PubMed id 18813352)1 Lincz L.F....Seldon M. (Neoplasia 2008)
    669. A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells. (PubMed id 18057229)1 Machado-Pinilla R....Perona R. (Blood 2008)
    670. Expression of human telomerase reverse transcriptase in bone marrow CD34+ cells from patients with beta-thalassemia major. (PubMed id 18466174)1 Li X....Mu D. (Transfusion 2008)
    671. Quantitative analysis of hTERT mRNA levels in cells microdissected from cytological specimens. (PubMed id 18795940)1 Fujita H....Tanaka M. (Cancer Sci. 2008)
    672. Evaluation of telomerase activity in gingival fibroblasts of cyclosporine-treated patients. (PubMed id 18261581)1 Biray C....Camsari T. (Transplant. Proc. 2008)
    673. Endometrial telomerase shows specific expression patterns in different types of reproductive failure. (PubMed id 18765014)1 Hapangama D.K....Quenby S. (Reprod. Biomed. Online 2008)
    674. Reduced telomerase activity in human T lymphocytes exposed to cortisol. (PubMed id 18222063)1 Choi J....Effros R.B. (Brain Behav. Immun. 2008)
    675. Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. (PubMed id 18714398)1 Grochola L.F....WA1rl P. (Neoplasia 2008)
    676. NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes. (PubMed id 18505829)1 Xu M....Galloway D.A. (Mol. Cell. Biol. 2008)
    677. Antisense human telomerase reverse transcriptase could partially reverse malignant phenotypes of gastric carcinoma cell line in vitro. (PubMed id 18414191)1 Yang S.M....Liang G.P. (Eur. J. Cancer Prev. 2008)
    678. siRNA-mediated inhibition of hTERT enhances chemosensitivity of hepatocellular carcinoma. (PubMed id 18708758)1 Guo X....Wei L. (amp 2008)
    679. Effects of telomerase activity on carcinogenesis and survival in laryngeal carcinoma. (PubMed id 18380945)1 Chen M....Zhang X. (J. Int. Med. Res. 2008)
    680. Estrogen receptor-alpha mediates the effects of estradiol on telomerase activity in human mesenchymal stem cells. (PubMed id 18719354)1 Cha Y....Park K.S. (Mol. Cells 2008)
    681. Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition. (PubMed id 18358095)1 Zhao Y.M....Huang H. (Acta Pharmacol. Sin. 2008)
    682. Telomerase reconstitution contributes to resetting of circadian rhythm in fibroblasts. (PubMed id 18398672)1 Qu Y....Mu D. (Mol. Cell. Biochem. 2008)
    683. Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc. (PubMed id 18818322)1 Liu X....Schlegel R. (J. Virol. 2008)
    684. Detection of hTERT mRNA in gastrointestinal tract cancer specimens. (PubMed id 18564721)1 Udomchaiprasertkul W....Leelawat K. (Southeast Asian J. Trop. Med. Public Health 2008)
    685. Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution. (PubMed id 18363039)1 Qu Y....Mu D. (Mol. Cell. Biochem. 2008)
    686. Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells. (PubMed id 18339310)1 Zhao Y.M....Huang H. (Biochem. Biophys. Res. Commun. 2008)
    687. Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma: an immunohistochemical study. (PubMed id 18822693)1 BozdoA9an O....BaA9ar H. (Tumori 2008)
    688. Immunohistochemical localization of telomerase in myomas and in uterine myometrium. (PubMed id 18584973)1 Madej P....Nowaczyk G. (Pathol. Res. Pract. 2008)
    689. Relationship between physical activity level, telomere length, and telomerase activity. (PubMed id 18799986)1 Ludlow A.T....Roth S.M. (Med Sci Sports Exerc 2008)
    690. [Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance]. (PubMed id 18250061)1 Wu P....Jiang Y.D. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    691. Establishment of immortalized human hepatocytes by introduction of HPV16 E6/E7 and hTERT as cell sources for liver cell-based therapy. (PubMed id 19177844)1 Tsuruga Y....Todo S. (Cell Transplant 2008)
    692. Multistep regulation of telomerase during differentiation of HL60 cells. (PubMed id 18276798)1 Yamada O....Matsuoka R. (J. Leukoc. Biol. 2008)
    693. CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. (PubMed id 18546260)1 Zhang C....Wei L. (Int. J. Cancer 2008)
    694. Mesenchymal stem cells from Chinese Guizhou minipig by hTERT gene transfection. (PubMed id 18374125)1 Wei L.L....Lu Y.R. (Transplant. Proc. 2008)
    695. Cyclin-dependent kinase inhibitor p16(INK4a) and telomerase may co-modulate endothelial progenitor cells senescence. (PubMed id 18343732)1 Yang D.G....Zheng X.Y. (Ageing Res. Rev. 2008)
    696. Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene. (PubMed id 18197256)1 Zhu Q....Xu D. (PLoS ONE 2008)
    697. The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1. (PubMed id 17198740)1 Burnworth B....Boukamp P. (Eur. J. Cell Biol. 2007)
    698. Telomerase in nasal polyps. (PubMed id 17621823)1 Chen Y.S....Lorenzen J. (Am J Rhinol 2007)
    699. TAK1 represses transcription of the human telomerase reverse transcriptase gene. (PubMed id 17325661)1 Fujiki T....Katakura Y. (Oncogene 2007)
    700. Modulation of telomere shelterin by TRF1 [corrected] and TRF2 interacts with telomerase to maintain the telomere length in non-small cell lung cancer. (PubMed id 17681636)1 Hsu C.P....Lee L.W. (Lung Cancer 2007)
    701. [Significance of FCM-DNA ploidy pattern, AgNOR counting, hTERT and PCNA expression in differentiating malignant from benign serous effusion]. (PubMed id 17298749)1 Wu L.Y....Jiang Y. (Ai Zheng 2007)
    702. Telomerase activity of basal cell carcinoma in patients living in North Queensland, Australia. (PubMed id 17391727)1 Saleh S....Ho Y.H. (Hum. Pathol. 2007)
    703. p53-dependent integration of telomere and growth factor deprivation signals. (PubMed id 17360541)1 Beliveau A....Yaswen P. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    704. Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcome. (PubMed id 17344921)1 Terrin L....De Rossi A. (Leukemia 2007)
    705. TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. (PubMed id 17237767)1 Xin H....Songyang Z. (Nature 2007)
    706. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. (PubMed id 17974918)1 Okawa T....Rustgi A.K. (amp 2007)
    707. Analysis of hTERT expression in exfoliated cells from patients with bladder transitional cell carcinomas using SYBR green real-time fluorescence quantitative PCR. (PubMed id 17961306)1 Xie X.Y....Liu Z.J. (Ann. Clin. Biochem. 2007)
    708. Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation. (PubMed id 17565702)1 Graakjaer J....Serakinci N. (BMC Mol. Biol. 2007)
    709. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene. (PubMed id 17611690)1 Kitagawa M....Takata T. (Int. J. Oncol. 2007)
    710. Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia. (PubMed id 17726237)1 Bellon M. and Nicot C. (amp 2007)
    711. Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA. (PubMed id 17204238)1 Jalink M....Xu D. (Biochem. Biophys. Res. Commun. 2007)
    712. p53 and hTERT determine sensitivity to viral apoptosis. (PubMed id 17855516)1 Nguyen M.L....Blaho J.A. (J. Virol. 2007)
    713. Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. (PubMed id 17487429)1 Tang W.K....Tang J.C. (Int. J. Mol. Med. 2007)
    714. Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells. (PubMed id 17713555)1 Prade-Houdellier N....Beyne-Rauzy O. (Leukemia 2007)
    715. The loss of telomerase activity in highly differentiated CD8+CD28- CD27- T cells is associated with decreased Akt (Ser473) phosphorylation. (PubMed id 17548608)2 Plunkett F.J....Akbar A.N. (J. Immunol. 2007)
    716. Telomerase activation in neoplastic cell immortalization and tumour progression. (PubMed id 19105326)1 Looi L.M....Cheah P.L. (Malays J Pathol 2007)
    717. Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop. (PubMed id 17134697)1 Lai S.R....Tollefsbol T.O. (Exp. Cell Res. 2007)
    718. Studies on RNA-protein interactions and enzyme activity by mutational analysis of telomerase. (PubMed id 18029765)1 Ohsako Y....Uesugi S. (Nucleic Acids Symp Ser (Oxf) 2007)
    719. Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma. (PubMed id 17673177)1 Choi J.H....Park A.J. (Biochem. Biophys. Res. Commun. 2007)
    720. Telomere length, telomerase activity, and expressions of human telomerase mRNA component (hTERC) and human telomerase reverse transcriptase (hTERT) mRNA in pulmonary neuroendocrine tumors. (PubMed id 17060405)1 Nishio Y....Kawai T. (Jpn. J. Clin. Oncol. 2007)
    721. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. (PubMed id 17433324)1 Lechel A....Rudolph K.L. (Gastroenterology 2007)
    722. hTERT inhibits the Epstein-Barr virus lytic cycle and promotes the proliferation of primary B lymphocytes: implications for EBV-driven lymphomagenesis. (PubMed id 17417773)1 Terrin L....De Rossi A. (Int. J. Cancer 2007)
    723. [DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma]. (PubMed id 17686286)1 Zhong M....Gong Y.B. (Zhonghua Kou Qiang Yi Xue Za Zhi 2007)
    724. Resistance to Ara-C up-regulates the activation of NF-kappaB, telomerase activity and Fas expression in NALM-6 cells. (PubMed id 17978477)1 Kanno S....Ishikawa M. (amp 2007)
    725. Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart. (PubMed id 17274981)1 Serakinci N....Kolvraa S. (Exp. Cell Res. 2007)
    726. [Correlation of hTERT expression to maspin and bFGF expression and their significance in glioma]. (PubMed id 17562265)1 Wang D.L....Huang H. (Ai Zheng 2007)
    727. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1 Roche S....Favrot M.C. (J. Cell. Biochem. 2007)
    728. [Anti-tumor effects of chemotherapeutic drugs on human gastric cancer cells in vitro and the relationship with expression of hTERT mRNA]. (PubMed id 18396642)1 Geng M....Tai Y.H. (Zhonghua Zhong Liu Za Zhi 2007)
    729. Direct visualization of the binding of c-Myc/Max heterodimeric b-HLH-LZ to E-box sequences on the hTERT promoter. (PubMed id 17705400)1 Lebel R....Grandbois M. (Biochemistry 2007)
    730. Knocking down p53 with siRNA does not affect the overexpression of p21WAF-1 after exposure of IMR-90 hTERT fibroblasts to a sublethal concentration of H2O2 leading to premature senescence. (PubMed id 17460194)1 Zdanov S....Toussaint O. (Ann. N. Y. Acad. Sci. 2007)
    731. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. (PubMed id 16517060)1 Yim H.W....Taylor J.A. (Cancer Lett. 2007)
    732. Telomerase activity in colorectal cancer, prognostic factor and implications in the microsatellite instability pathway. (PubMed id 17657844)1 Vidaurreta M....Arroyo M. (World J. Gastroenterol. 2007)
    733. Increased telomerase activity and human telomerase reverse transcriptase mRNA expression in the endometrium of patients with endometriosis. (PubMed id 17077107)1 Kim C.M....Lee B.S. (Hum. Reprod. 2007)
    734. Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. (PubMed id 17641414)1 Soreide K....Baak J.P. (Cell. Oncol. 2007)
    735. Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. (PubMed id 17534147)1 Beliveau A. and Yaswen P. (Cell Cycle 2007)
    736. Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells. (PubMed id 17996122)1 Bu X....Wei L. (BMC Cancer 2007)
    737. [Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes]. (PubMed id 17331439)1 Gao Y.J....Huang Y. (Zhonghua Kou Qiang Yi Xue Za Zhi 2007)
    738. Human telomerase exists in two distinct active complexes in vivo. (PubMed id 17383981)1 Mizuno H....Murakami S. (J. Biochem. 2007)
    739. Synergistic activation of extracellular signal-regulated kinase in human dermal fibroblasts by human telomerase reverse transcriptase and transforming growth factor-beta1. (PubMed id 17662305)1 Liu W.R....Mustoe T.A. (J. Surg. Res. 2007)
    740. Expression of hTERT, p53 and PCNA in cystitis glandularis. (PubMed id 17828505)1 Wei Z....Chen Z. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2007)
    741. Telomerase unplugged. (PubMed id 17373762)1 Cristofari G....Lingner J. (ACS Chem. Biol. 2007)
    742. DNA methylation is not likely to be responsible for hTERT expression in premalignant cervical lesions. (PubMed id 17609503)1 Oikonomou P....Tsezou A. (Exp. Biol. Med. (Maywood) 2007)
    743. Immortalization and characterization of porcine ventricular endocardial endothelial cells. (PubMed id 17364895)1 Kuruvilla L....Kartha C.C. (Endothelium 2007)
    744. Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. (PubMed id 17267411)1 Renaud S....Benhattar J. (Nucleic Acids Res. 2007)
    745. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. (PubMed id 17267499)1 Katzenellenbogen R.A.... Galloway D.A. (J. Virol. 2007)
    746. Identification of apoptosis-related PLZF target genes. (PubMed id 17537403)1 Bernardo M.V....Parrado A. (Biochem. Biophys. Res. Commun. 2007)
    747. Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT. (PubMed id 16412982)1 Matsubara Y....Ikeda Y. (Biochem. Biophys. Res. Commun. 2006)
    748. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation. (PubMed id 16332973)2 Vulliamy T.J....Dokal I. (Blood 2006)
    749. Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. (PubMed id 16575014)1 Wang L....Bondy M.L. (J. Clin. Oncol. 2006)
    750. hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. (PubMed id 16619047)1 Massard C....Soria J.C. (Oncogene 2006)
    751. Quantitative determination of human telomerase reverse transcriptase messenger RNA expression in premalignant cervical lesions and correlation with human papillomavirus load. (PubMed id 16426912)1 Oikonomou P....Tsezou A. (Hum. Pathol. 2006)
    752. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. (PubMed id 16772337)1 Wu Y.L....SAcgal-Bendirdjian E. (J. Cell. Sci. 2006)
    753. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. (PubMed id 16613901)1 Santos J.H....Van Houten B. (Hum. Mol. Genet. 2006)
    754. Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. (PubMed id 16354694)1 Ge Z....Xu D. (Mol. Cell. Biol. 2006)
    755. Receptor Ck-dependent signaling regulates hTERT gene transcription. (PubMed id 16405739)1 Sikand K....Varma N. (BMC Cell Biol. 2006)
    756. Alteration of hTERT full-length variant expression level showed different gene expression profiles and genomic copy number changes in breast cancer. (PubMed id 16525654)1 Rha S.Y....Chung H.C. (Oncol. Rep. 2006)
    757. Telomerase antisense inhibition for the proliferation of endometrial cancer in vitro and in vivo. (PubMed id 17177836)1 Chen X.J....Wang S.Q. (Int. J. Gynecol. Cancer 2006)
    758. Human telomerase reverse transcriptase protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal. (PubMed id 16673017)1 Li S....Elwood N.J. (Leukemia 2006)
    759. Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1. (PubMed id 16843438)1 Jagadeesh S. and Banerjee P.P. (Biochem. Biophys. Res. Commun. 2006)
    760. Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth. (PubMed id 17026956)2 Rahman R.... Cui W. (Biochem. Biophys. Res. Commun. 2006)
    761. Prognostic implication of telomerase activity in patients with brain tumors. (PubMed id 16479078)1 Kim C.H....Oh S.J. (J. Korean Med. Sci. 2006)
    762. Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer. (PubMed id 17060942)1 Kailash U....Das B.C. (Br. J. Cancer 2006)
    763. Mechanisms regulating the proliferative potential of human CD8+ T lymphocytes overexpressing telomerase. (PubMed id 16951325)1 Menzel O....Rufer N. (J. Immunol. 2006)
    764. Specific subtelomere loss on chromosome der(11)t(3;11)(q23;q23)x2 in anaplastic thyroid cancer cell line OCUT-1. (PubMed id 16786150)1 Kammori M....Takubo K. (Int. J. Mol. Med. 2006)
    765. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. (PubMed id 16323248)2 Cole D.K.... Jakobsen B.K. (Eur. J. Immunol. 2006)
    766. hTERT immunopositivity patterns in the normal brain and in astrocytic tumors. (PubMed id 16614861)1 Kotoula V....Karkavelas G. (Acta Neuropathol. 2006)
    767. Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. (PubMed id 17465827)1 Serakinci N....Keith W.N. (Regen Med 2006)
    768. Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro. (PubMed id 16810748)1 Wang Y.F....Xia Q. (World J. Gastroenterol. 2006)
    769. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1 Nousiainen M....KAPrner R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    770. Interferon-induced sensitization to apoptosis is associated with repressed transcriptional activity of the hTERT promoter in multiple myeloma. (PubMed id 16460686)1 Lindkvist A....Paulsson-Karlsson Y. (Biochem. Biophys. Res. Commun. 2006)
    771. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. (PubMed id 16794190)1 Matthews C....Bennett M. (Circ. Res. 2006)
    772. Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. (PubMed id 16688717)1 Li H.M....Tsao S.W. (Int. J. Cancer 2006)
    773. Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues. (PubMed id 16939641)1 SaebA...Gaudernack G. (BMC Mol. Biol. 2006)
    774. Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. (PubMed id 16641908)1 Zhu C.Q....Tsao M.S. (Br. J. Cancer 2006)
    775. A major role of PKC theta and NFkappaB in the regulation of hTERT in human T lymphocytes. (PubMed id 17141225)1 Sheng W.Y....Wang T.C. (FEBS Lett. 2006)
    776. The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity. (PubMed id 16714764)1 Keppler B.R....Jarstfer M.B. (J. Biol. Chem. 2006)
    777. Expression of telomerase (hTERT) in aldosterone-producing adrenocortical tumors. (PubMed id 16465394)1 Sticchi D....Rossi G.P. (Int. J. Mol. Med. 2006)
    778. HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300. (PubMed id 16708385)1 James M.A....Klingelhutz A.J. (Int. J. Cancer 2006)
    779. Effects of hTERT on metal ion-induced genomic instability. (PubMed id 16449970)1 Glaviano A....Case C.P. (Oncogene 2006)
    780. Human short-term repopulating cells have enhanced telomerase reverse transcriptase expression. (PubMed id 16861355)1 JAorAYs M....Fan X. (Blood 2006)
    781. hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells. (PubMed id 17172814)1 Yang L.F....Cao Y. (amp 2006)
    782. Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. (PubMed id 16170363)1 Anderson C.J....Keith W.N. (Oncogene 2006)
    783. Inhibition of human telomerase reverse transcriptase in hep-2 cells using short hairpin RNA expression vectors. (PubMed id 16490880)1 Chen S.M....Cai Q. (amp 2006)
    784. Telomerase activity and hTERT mRNA expression in glial tumors. (PubMed id 16685456)1 Boldrini L....Fontanini G. (Int. J. Oncol. 2006)
    785. [Construction of tumor cell-specific expression vector modulated by human telomerase reserse transcription gene core promoter]. (PubMed id 16388756)1 Li H.M....Zhang M. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006)
    786. Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma. (PubMed id 16937491)1 Yao D.F....Meng X.Y. (World J. Gastroenterol. 2006)
    787. The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein. (PubMed id 15655249)1 Liu X....Schlegel R. (J. Biol. Chem. 2005)
    788. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A....Aebersold R. (Nat. Methods 2005)
    789. Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes. (PubMed id 16002425)1 Schreurs M.W....Hooijberg E. (Blood 2005)
    790. HTERT mRNA partially regulates telomerase activity in gastric adenocarcinoma and adjacent normal gastric mucosa. (PubMed id 16047476)1 Barclay J.Y....Nwokolo C.U. (Dig. Dis. Sci. 2005)
    791. The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes. (PubMed id 16036112)1 Glasspool R.M....Keith W.N. (Neoplasia 2005)
    792. Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells. (PubMed id 15629899)1 Matsumura-Arioka Y....Nakamura M. (Int. Immunol. 2005)
    793. CTCF binds the proximal exonic region of hTERT and inhibits its transcription. (PubMed id 16326864)1 Renaud S....Benhattar J. (Nucleic Acids Res. 2005)
    794. Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. (PubMed id 15632080)1 Kelleher C....Lingner J. (Mol. Cell. Biol. 2005)
    795. Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. (PubMed id 16020509)1 Beyne-Rauzy O....Mansat-De Mas V. (Blood 2005)
    796. Differential effects of TGF-beta1 on telomerase activity in thyroid carcinoma cell lines. (PubMed id 16288728)1 Lindkvist A....Paulsson-Karlsson Y. (Biochem. Biophys. Res. Commun. 2005)
    797. Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer. (PubMed id 15788678)1 Ohuchida K....Tanaka M. (Clin. Cancer Res. 2005)
    798. Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase. (PubMed id 16120835)1 Moriarty T.J....Autexier C. (RNA 2005)
    799. The effect of TERC haploinsufficiency on the inheritance of telomere length. (PubMed id 16284252)1 Goldman F....Bessler M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    800. Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. (PubMed id 15741219)1 RAPth A....Lansdorp P.M. (Blood 2005)
    801. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. (PubMed id 16043710)1 Zaug A.J....Cech T.R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    802. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. (PubMed id 16264179)1 Alonso M.M....Gomez-Manzano C. (J. Natl. Cancer Inst. 2005)
    803. Usefulness of immunological detection of the human telomerase reverse transcriptase. (PubMed id 16373967)1 Volpi A....Amadori D. (Cell. Oncol. 2005)
    804. [Effects of tea polyphenols on cell proliferation and hTERT of human Tca8113 cell lines]. (PubMed id 16329824)1 Yao H....Fan J. (Zhonghua Kou Qiang Yi Xue Za Zhi 2005)
    805. Human telomerase RNA template sequence is a determinant of telomere repeat extension rate. (PubMed id 16061476)1 Drosopoulos W.C....Prasad V.R. (J. Biol. Chem. 2005)
    806. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. (PubMed id 16172394)1 Wang J.C....Dick J.E. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    807. Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. (PubMed id 16135795)1 Takakura M....Shay J.W. (Mol. Cell. Biol. 2005)
    808. Telomerase can act as a template- and RNA-independent terminal transferase. (PubMed id 15994230)1 Lue N.F....Leng S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    809. [Study on apoptosis of human cervical carcinoma HeLa cells with RNA interference targeting hTERT]. (PubMed id 15989808)1 Zhao Y....Yang A.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005)
    810. Switching human telomerase on and off with hPOT1 protein in vitro. (PubMed id 15792951)1 Lei M....Cech T.R. (J. Biol. Chem. 2005)
    811. Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway. (PubMed id 15849192)1 Wang J....Li D.W. (J. Biol. Chem. 2005)
    812. Dynamic behavior of the telomerase RNA hairpin structure and its relationship to dyskeratosis congenita. (PubMed id 15808851)1 Yingling Y.G. and Shapiro B.A. (J. Mol. Biol. 2005)
    813. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. (PubMed id 15928077)1 Masutomi K....Hahn W.C. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    814. Abnormal expression of hepatomas and circulating telomerase and its clinical values. (PubMed id 16286259)1 Wu W....Zou L. (amp 2005)
    815. Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene. (PubMed id 15809044)1 Bentzon J.F....Kassem M. (Biochem. Biophys. Res. Commun. 2005)
    816. Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia. (PubMed id 15158092)1 Verstovsek S....Albitar M. (Leuk. Res. 2004)
    817. Genomic instability is associated with lack of telomerase activation in ovarian cancer. (PubMed id 15477760)1 Landen C.N....Sood A.K. (amp 2004)
    818. Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ. (PubMed id 15010825)1 Liu J....Sahin A. (Int. J. Oncol. 2004)
    819. Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ). (PubMed id 14961580)1 Snijders P.J....Smit E.F. (Int. J. Cancer 2004)
    820. Regulation of telomerase by telomeric proteins. (PubMed id 15189140)1 Smogorzewska A. and de Lange T. (Annu. Rev. Biochem. 2004)
    821. Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization. (PubMed id 15308640)1 Taylor L.M....Mackenzie K.L. (J. Biol. Chem. 2004)
    822. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. (PubMed id 14744757)1 Yang H....Cheng J.Q. (Cancer Res. 2004)
    823. The hTERT gene is embedded in a nuclease-resistant chromatin domain. (PubMed id 15516693)1 Wang S. and Zhu J. (J. Biol. Chem. 2004)
    824. Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts. (PubMed id 14743210)1 Noble J.R....Reddel R.R. (Oncogene 2004)
    825. Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer. (PubMed id 15112354)1 Zhou G.X....Zhang H. (World J. Gastroenterol. 2004)
    826. Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. (PubMed id 15326479)1 Dudognon C....SAcgal-Bendirdjian E. (Oncogene 2004)
    827. Regulation of telomerase and its hTERT messenger in colorectal cancer. (PubMed id 14719074)1 Boldrini L....Fontanini G. (Oncol. Rep. 2004)
    828. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. (PubMed id 15485861)1 Jiang F....Bai W. (J. Biol. Chem. 2004)
    829. Tracking telomerase. (PubMed id 15055591)1 Greider C.W. and Blackburn E.H. (Cell 2004)
    830. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. (PubMed id 14570874)1 Naka K....Motoyama N. (J. Biol. Chem. 2004)
    831. Divergent expression changes of telomerase and E6/E7 mRNA, following integration of human papillomavirus type 33 in cultured epithelial cells. (PubMed id 15198189)1 Peitsaro P....Johansson B. (Scand. J. Infect. Dis. 2004)
    832. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. (PubMed id 15371341)1 Gewin L.... Galloway D.A. (Genes Dev. 2004)
    833. Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. (PubMed id 15528369)1 Dagarag M....Effros R.B. (J. Immunol. 2004)
    834. Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. (PubMed id 15073136)1 Shin K.H....Park N.H. (Clin. Cancer Res. 2004)
    835. HIV-Tat down-regulates telomerase activity in the nucleus of human CD4+ T cells. (PubMed id 15017382)1 Franzese O....Bonmassar E. (Cell Death Differ. 2004)
    836. Emerging role of p53, bcl-2 and telomerase activity in Egyptian breast cancer patients. (PubMed id 15545228)1 Swellam M....Mokhtar N. (IUBMB Life 2004)
    837. In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues. (PubMed id 14719058)1 Baykal A....Liu J. (Oncol. Rep. 2004)
    838. Expression of human telomerase reverse transcriptase in gastrointestinal stromal tumors occurs preferentially in malignant neoplasms. (PubMed id 15492990)1 Sabah M....Kay E. (Hum. Pathol. 2004)
    839. Evaluation of telomerase mRNA (hTERT) in childhood acute leukemia. (PubMed id 15621763)1 Cogulu O....Ozkinay C. (amp 2004)
    840. Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions. (PubMed id 14654902)1 Amioka T....Chayama K. (Oncol. Rep. 2004)
    841. Human telomerase catalyzes nucleolytic primer cleavage. (PubMed id 15096579)1 Huard S. and Autexier C. (Nucleic Acids Res. 2004)
    842. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. (PubMed id 14767556)1 Mittal A....Katiyar S.K. (Int. J. Oncol. 2004)
    843. Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span. (PubMed id 15215158)1 Nisato R.E....Pepper M.S. (Am. J. Pathol. 2004)
    844. Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. (PubMed id 15263087)1 Won J....Kim T.K. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    845. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    846. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). (PubMed id 15199161)1 Nishi H....Isaka K. (Mol. Cell. Biol. 2004)
    847. Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. (PubMed id 15226182)1 Sinha-Datta U....Nicot C. (Blood 2004)
    848. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. (PubMed id 15569357)1 Santos J.H....Van Houten B. (Aging Cell 2004)
    849. Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. (PubMed id 15060173)1 Armbruster B.N....Counter C.M. (Mol. Cell. Biol. 2004)
    850. Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells. (PubMed id 15595642)1 Yang J....Cao Y. (amp 2004)
    851. DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. (PubMed id 15190070)1 Lee G.E....Chung I.K. (J. Biol. Chem. 2004)
    852. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. (PubMed id 15001567)1 Walter M....Roth M.G. (J. Biol. Chem. 2004)
    853. Immortalisation of human ovarian surface epithelium with telomerase and temperature-sensitive SV40 large T antigen. (PubMed id 12915130)1 Davies B.R....O'Hare M.J. (Exp. Cell Res. 2003)
    854. Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma. (PubMed id 12918126)1 Zhou J.H....Yang D.T. (World J. Gastroenterol. 2003)
    855. Putative telomere-recruiting domain in the catalytic subunit of human telomerase. (PubMed id 12697823)1 Armbruster B.N....Counter C.M. (Mol. Cell. Biol. 2003)
    856. Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. (PubMed id 14606063)1 Li C....Wu X.Y. (World J. Gastroenterol. 2003)
    857. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. (PubMed id 12393449)1 Kawano Y....Hamada H. (Blood 2003)
    858. Evaluation of telomerase in non-melanoma skin cancer. (PubMed id 12684697)1 Boldrini L....Fontanini G. (Int. J. Mol. Med. 2003)
    859. Renal cell carcinoma (RCC) and telomerase activity: relationship to stage. (PubMed id 14693268)1 Mekhail T.M....Bukowski R. (Urol. Oncol. 2003)
    860. Telomerase reverse transcriptase promoter regulation during myogenic differentiation of human RD rhabdomyosarcoma cells. (PubMed id 12939399)1 Ma H....Goodison S. (Mol. Cancer Res. 2003)
    861. Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. (PubMed id 12729798)1 Kaul S.C....Wadhwa R. (Exp. Cell Res. 2003)
    862. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. (PubMed id 12576506)1 Walter M....Ioannou Y.A. (J. Lipid Res. 2003)
    863. Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. (PubMed id 12611896)1 Wang S. and Zhu J. (J. Biol. Chem. 2003)
    864. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. (PubMed id 12517770)1 Akiyama M....Anderson K.C. (Cancer Res. 2003)
    865. Gene expression of telomerase related proteins in human normal oral and ectocervical epithelial cells. (PubMed id 12747968)1 Fujimoto R....Yasumoto S. (Oral Oncol. 2003)
    866. Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells. (PubMed id 14688476)1 Hauguel T. and Bunz F. (amp 2003)
    867. Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours. (PubMed id 14532990)1 Wisman G.B....Van der Zee A.G. (Int. J. Oncol. 2003)
    868. A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity. (PubMed id 14612390)1 Lue N.F....Mian I.S. (Mol. Cell. Biol. 2003)
    869. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. (PubMed id 12674332)1 Gronthos S....Shi S. (J. Bone Miner. Res. 2003)
    870. Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes. (PubMed id 14562019)1 Shin K.H....Park N.H. (Br. J. Cancer 2003)
    871. Catalytically active human telomerase mutants with allele-specific biological properties. (PubMed id 12915119)1 Kim M....Blackburn E.H. (Exp. Cell Res. 2003)
    872. Reversal of human cellular senescence: roles of the p53 and p16 pathways. (PubMed id 12912919)1 BeausAcjour C.M....Campisi J. (EMBO J. 2003)
    873. Interaction of human telomerase with its primer substrate. (PubMed id 12525188)1 Wallweber G....Pruzan R. (Biochemistry 2003)
    874. Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. (PubMed id 12545159)1 Lee S.H....Lee J.H. (Oncogene 2003)
    875. Clinical implications of quantitative real-time RT-PCR analysis of hTERT gene expression in human gliomas. (PubMed id 12592364)1 Tchirkov A....Verrelle P. (Br. J. Cancer 2003)
    876. Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. (PubMed id 12480519)1 Renaud S....Benhattar J. (Biochem. Biophys. Res. Commun. 2003)
    877. Telomerase expression as a marker in prostate cancer: correlation to clinicopathologic predictors. (PubMed id 15053304)1 Athanassiadou P....Giannopoulos A. (amp 2003)
    878. Telomerase levels control the lifespan of human T lymphocytes. (PubMed id 12689947)1 Roth A....Luiten R.M. (Blood 2003)
    879. Significance of immunological detection of human telomerase reverse transcriptase: re-evaluation of expression and localization of human telomerase reverse transcriptase. (PubMed id 12937127)1 Kyo S....Inoue M. (Am. J. Pathol. 2003)
    880. Development of a highly sensitive RT-PCR luminometric hybridization assay for human telomerase reverse-transcriptase beta-plus transcript. (PubMed id 14981931)1 Angelopoulou K....Lianidou E.S. (Anticancer Res. 2003)
    881. Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. (PubMed id 14562040)1 Wang L....Mao L. (Oncogene 2003)
    882. Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. (PubMed id 12702554)1 Lindvall C....Xu D. (Cancer Res. 2003)
    883. DNA damage transiently increases TRF2 mRNA expression and telomerase activity. (PubMed id 14513051)1 Klapper W....Parwaresch R. (Leukemia 2003)
    884. Telomerase activity in cell lines of pediatric soft tissue sarcomas. (PubMed id 12904596)1 Kleideiter E....Klotz U. (Pediatr. Res. 2003)
    885. [The expression of human telomerase reverse transcriptase mRNA and its significance in acute leukemia]. (PubMed id 12667285)1 Meng X.L....Jin J. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2003)
    886. Telomerase activity, expression of Bcl-2 and cell cycle regulation in doxorubicin resistant gastric carcinoma cell lines. (PubMed id 12579337)1 Yoon K.A....Park J.G. (Int. J. Mol. Med. 2003)
    887. [Detection of telomerase activity by semi-quantitative and in situ assays and quantification of hTERT expression in bladder carcinomas]. (PubMed id 12765058)1 Longchampt E....Lidereau R. (Prog. Urol. 2003)
    888. Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. (PubMed id 12843187)1 Wetterau L.A....Cohen P. (J. Clin. Endocrinol. Metab. 2003)
    889. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. (PubMed id 12939398)1 Harada H....Rustgi A.K. (Mol. Cancer Res. 2003)
    890. hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. (PubMed id 12759234)1 Fan X....Eberhart C.G. (Am. J. Pathol. 2003)
    891. Changes in N-glycosylation of human stromal cells by telomerase expression. (PubMed id 12565858)1 Kuwahara I....Furukawa K. (Biochem. Biophys. Res. Commun. 2003)
    892. Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. (PubMed id 12810068)1 Lopatina N.G....Tollefsbol T.O. (Biochem. Biophys. Res. Commun. 2003)
    893. Telomerase maintains telomere structure in normal human cells. (PubMed id 12887925)1 Masutomi K....Hahn W.C. (Cell 2003)
    894. Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts. (PubMed id 12496279)1 Gorbunova V....Pereira-Smith O.M. (J. Biol. Chem. 2003)
    895. Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis. (PubMed id 12918139)1 Liu D.Y....Zhou C.Z. (World J. Gastroenterol. 2003)
    896. hTERT associates with human telomeres and enhances genomic stability and DNA repair. (PubMed id 12527915)1 Sharma G.G....Pandita T.K. (Oncogene 2003)
    897. Imbalance between apoptosis and telomerase activity in myelodysplastic syndromes: possible role in ineffective hemopoiesis. (PubMed id 12952227)1 Ohshima K....Kikuchi M. (amp 2003)
    898. Full-length telomerase reverse transcriptase messenger RNA is an independent prognostic factor in neuroblastoma. (PubMed id 12598334)1 Krams M....Rudolph P. (Am. J. Pathol. 2003)
    899. Expression-patterns of the RNA component (hTR)and the catalytic subunit (hTERT) of human telomerase in nonneoplastic prostate tissue, prostatic intraepithelial neoplasia, and prostate cancer. (PubMed id 12661034)1 Bettendorf O....Poremba C. (Prostate 2003)
    900. Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. (PubMed id 14585993)1 Sharma G.G....Pandita T.K. (Mol. Cell. Biol. 2003)
    901. Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells. (PubMed id 12646176)1 Zhou C. and Liu J. (Biochem. Biophys. Res. Commun. 2003)
    902. Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells. (PubMed id 12939469)1 Zhou C....Boggess J.F. (Mol. Cancer Ther. 2003)
    903. Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. (PubMed id 12508351)1 Lan J....Guo G.S. (World J. Gastroenterol. 2003)
    904. Functional conservation of the telomerase protein Est1p in humans. (PubMed id 12699629)1 Snow B.E.... Harrington L. (Curr. Biol. 2003)
    905. Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis. (PubMed id 14568262)1 Oh B.K....Nyun Park Y. (J. Hepatol. 2003)
    906. Relationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significance. (PubMed id 12632490)1 Shao J.C....Zhang H. (World J. Gastroenterol. 2003)
    907. Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. (PubMed id 12586632)1 Luiten R.M....Spits H. (Blood 2003)
    908. Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. (PubMed id 12034742)1 Rubio M.A....Campisi J. (J. Biol. Chem. 2002)
    909. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. (PubMed id 12140282)1 Gorbunova V....Pereira-Smith O.M. (J. Biol. Chem. 2002)
    910. p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. (PubMed id 12420227)1 Herbert B.S....Shay J.W. (Oncogene 2002)
    911. Telomerase activity in breast cancer in Western India (Gujarat). (PubMed id 11936586)1 Shah N.G....Trivedi K.A. (Int. J. Biol. Markers 2002)
    912. [Detection of telomerase hTERT gene expression of exfoliated cell in broncho-alveolar lavage fluid]. (PubMed id 12452048)1 Ma G....Rong T.H. (Ai Zheng 2002)
    913. Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. (PubMed id 12359427)1 Sprague D.L....Klingelhutz A.J. (Virology 2002)
    914. Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome. (PubMed id 11788906)1 Mueller C....Ernst G. (Int. J. Oncol. 2002)
    915. [Telomerase expression in tarsal gland carcinoma]. (PubMed id 12487901)1 Li N....Chen C. (Zhonghua Yan Ke Za Zhi 2002)
    916. The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions. (PubMed id 11850805)1 Leem S.H....Larionov V. (Oncogene 2002)
    917. Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. (PubMed id 12181331)1 Horikawa I....Barrett J.C. (Mol. Biol. Cell 2002)
    918. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. (PubMed id 12193655)1 Stewart S.A....Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    919. Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity. (PubMed id 12209957)1 Guilleret I....Benhattar J. (Int. J. Cancer 2002)
    920. TERT regulates cell survival independent of telomerase enzymatic activity. (PubMed id 12082628)1 Cao Y....Liu J.P. (Oncogene 2002)
    921. Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells. (PubMed id 12368310)1 Yuan H....Schlegel R. (J. Virol. 2002)
    922. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. (PubMed id 11916966)1 Li H....Avraham H. (J. Biol. Chem. 2002)
    923. The expression of hTERT mRNA and cellular immunity in gastric cancer and precancerosis. (PubMed id 12174361)1 Yao X.X....Sun Z.C. (World J. Gastroenterol. 2002)
    924. Identification of serum anti-human telomerase reverse transcriptase (hTERT) auto-antibodies during progression to hepatocellular carcinoma. (PubMed id 12185596)1 Masutomi K....Kobayashi K. (Oncogene 2002)
    925. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. (PubMed id 12209700)1 Tomoda R....Uchida A. (Cancer 2002)
    926. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    927. Clinical significance of telomerase activity in multiple myeloma. (PubMed id 12001122)1 Shiratsuchi M....Nishimura J. (Cancer 2002)
    928. Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase. (PubMed id 11978176)1 Kim H....Foster D.N. (Biochem. J. 2002)
    929. hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. (PubMed id 12231532)1 Wang L....Khuri F.R. (Clin. Cancer Res. 2002)
    930. Telomerase rescues the expression levels of keratinocyte growth factor and insulin-like growth factor-II in senescent human fibroblasts. (PubMed id 12243757)1 Kanzaki Y....Ide T. (Exp. Cell Res. 2002)
    931. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. (PubMed id 12077343)1 Rheinwald J.G....O'Toole K.M. (Mol. Cell. Biol. 2002)
    932. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. (PubMed id 12077335)1 Nikiforov M.A....Cole M.D. (Mol. Cell. Biol. 2002)
    933. [Telomerase: an enzyme with multiple applications in cancer research]. (PubMed id 12415959)1 Castillo Ureta H....MartA-nez RodrA-guez H.G. ( organo del Hospital de Enfermedades de la NutriciĆ³n 2002)
    934. Stabilization of telomere length and karyotypic stability are directly correlated with the level of hTERT gene expression in primary fibroblasts. (PubMed id 12122013)1 Cui W....Clark A.J. (J. Biol. Chem. 2002)
    935. Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity. (PubMed id 11751869)1 Arai K....Murakami S. (J. Biol. Chem. 2002)
    936. Human Ku70/80 associates physically with telomerase through interaction with hTERT. (PubMed id 12377759)1 Chai W....Shay J.W. (J. Biol. Chem. 2002)
    937. Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras. (PubMed id 12082607)1 MacKenzie K.L....Moore M.A. (Oncogene 2002)
    938. Differential regulation of telomerase activity by six telomerase subunits. (PubMed id 12135483)1 Chang J.T....Cheng A.J. (Eur. J. Biochem. 2002)
    939. Telomerase activity in needle biopsied uterine myoma-like tumors: differential diagnosis between uterine sarcomas and leiomyomas. (PubMed id 11788902)1 Tsujimura A....Ogita S. (Int. J. Oncol. 2002)
    940. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. (PubMed id 11896211)1 Schnabl B....Brenner D.A. ( a journal of technical methods and pathology 2002)
    941. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. (PubMed id 11884529)1 Cerezo A....Boukamp P. (J. Cell. Sci. 2002)
    942. A novel mechanism of retinoic acid resistance in acute promyelocytic leukemia cells through a defective pathway in telomerase regulation. (PubMed id 11986943)1 Pendino F....SAcgal-Bendirdjian E. (Leukemia 2002)
    943. Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones. (PubMed id 12082531)1 Biroccio A....Zupi G. (Oncogene 2002)
    944. The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. (PubMed id 11855854)1 Hou M....Xu D. (Exp. Cell Res. 2002)
    945. Allosteric inhibitors of telomerase: oligonucleotide N3'--&gt;P5' phosphoramidates. (PubMed id 11788719)1 Pruzan R....Gryaznov S. (Nucleic Acids Res. 2002)
    946. Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer. (PubMed id 12119560)1 Kanamaru T....Takeyama Y. (Int. J. Mol. Med. 2002)
    947. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. (PubMed id 12198499)1 Wong J.M....Collins K. (Nat. Cell Biol. 2002)
    948. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. (PubMed id 12065682)1 Carney S.A....Dixon D. ( a journal of technical methods and pathology 2002)
    949. [Relationship between expressions of telomerase genes and apoptosis related genes in mammary ductal atypical hyperplasia]. (PubMed id 12452037)1 Song M....Song J.Y. (Ai Zheng 2002)
    950. Quantitative analysis of telomerase hTERT mRNA and telomerase activity in endometrioid adenocarcinoma and in normal endometrium. (PubMed id 11748987)1 Lehner R....Shroyer K.R. (Gynecol. Oncol. 2002)
    951. Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. (PubMed id 12032846)1 Xiang H....Li D.W. (Oncogene 2002)
    952. Nucleolar localization of hTERT protein is associated with telomerase function. (PubMed id 12083802)1 Yang Y....Weissman S.M. (Exp. Cell Res. 2002)
    953. Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells. (PubMed id 11942411)1 Zhang R.G....Xie H. (Cell Res. 2002)
    954. Methylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancers as analyzed by bisulfite PCR-SSCP. (PubMed id 11932355)1 Nomoto K....Kakizoe T. (Jpn. J. Clin. Oncol. 2002)
    955. Association between aplastic anaemia and mutations in telomerase RNA. (PubMed id 12090986)4 Vulliamy T....Mason P.J. (Lancet 2002)
    956. High telomerase activity correlates with the stabilities of genome and DNA ploidy in renal cell carcinoma. (PubMed id 11896565)1 Izumi H....Sasaki K. (Neoplasia 2002)
    957. Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity. (PubMed id 12379283)1 Ghattas M.H....Abraham N.G. (amp 2002)
    958. [Study on induction of leukemic cell apoptosis by antisense oligodeoxynucleotide of human telomerase RNA]. (PubMed id 11877080)1 Xie W. and Lin M. (Zhonghua Xue Ye Xue Za Zhi 2001)
    959. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus. (PubMed id 11517292)1 Yokoyama Y....Tamaya T. (Mol. Hum. Reprod. 2001)
    960. Mechanism for the reduction of telomerase expression during muscle cell differentiation. (PubMed id 11279234)1 Nozawa K....Isobe K. (J. Biol. Chem. 2001)
    961. Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression. (PubMed id 11859969)1 Simon M....Schramm J. (J. Neurooncol. 2001)
    962. [Study of telomerase activity and its related genes expression in leukemia cells]. (PubMed id 11877056)1 Xia F....Wang J. (Zhonghua Xue Ye Xue Za Zhi 2001)
    963. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. (PubMed id 11701125)1 Zhou X.Z. and Lu K.P. (Cell 2001)
    964. Human telomerase contains two cooperating telomerase RNA molecules. (PubMed id 11432839)1 Wenz C....Lingner J. (EMBO J. 2001)
    965. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. (PubMed id 11191110)1 Yi X....Shay J.W. (Neoplasia 2000)
    966. The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. (PubMed id 11191109)1 Colgin L.M....Reddel R.R. (Neoplasia 2000)
    967. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. (PubMed id 10837221)1 Kharbanda S....Kufe D. (Curr. Biol. 2000)
    968. Involvement of 14-3-3 proteins in nuclear localization of telomerase. (PubMed id 10835362)1 Seimiya H....Tsuruo T. (EMBO J. 2000)
    969. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. (PubMed id 10029071)1 Horikawa I.... Barrett J.C. (Cancer Res. 1999)
    970. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. (PubMed id 10224060)1 Kang S.S....Do S.I. (J. Biol. Chem. 1999)
    971. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. (PubMed id 10449030)1 Holt S.E....Glinsky G.V. (Mol. Carcinog. 1999)
    972. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. (PubMed id 9887342)1 Cong Y.S.... Bacchetti S. (Hum. Mol. Genet. 1999)
    973. Functional requirement of p23 and Hsp90 in telomerase complexes. (PubMed id 10197982)1 Holt S.E....White M.A. (amp 1999)
    974. Impaired telomerase activity in uninfected haematopoietic progenitors in HIV-1-infected patients. (PubMed id 9662195)1 Vignoli M....La Placa M. (AIDS 1998)
    975. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. (PubMed id 9751630)1 Ulaner G.A....Hoffman A.R. (Cancer Res. 1998)
    976. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. (PubMed id 9528864)1 Counter C.M....Weinberg R.A. (Oncogene 1998)
    977. Extension of life-span by introduction of telomerase into normal human cells. (PubMed id 9454332)1 Bodnar A.G....Wright W.E. (Science 1998)
    978. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. (PubMed id 9328464)1 Kilian A....Jefferson R.A. (Hum. Mol. Genet. 1997)
    979. Reverse transcriptase motifs in the catalytic subunit of telomerase. (PubMed id 9110970)1 Lingner J....Cech T.R. (Science 1997)
    980. Regulated expression of telomerase activity in human T lymphocyte development and activation. (PubMed id 8676067)2 Weng N.P.... Hodes R.J. (J. Exp. Med. 1996)
    981. Pulmonary Fibrosis, Familial (PubMed id 20301408)1 Pagon R.A....Stephens K. (1993)
    982. Dyskeratosis Congenita (PubMed id 20301779)1 Pagon R.A....Stephens K. (1993)
    983. RNA binding domain of telomerase reverse transcriptase. (PubMed id 11158287)9 Lai C.K....Collins K. (Mol. Cell. Biol. 2001)
    984. Immunohistochemical detection of telomerase reverse transcriptase (TERT) protein in benign and malignant tumor cells of the breast. (PubMed id 16026073)9 Ikeda S....Funakoshi N. (Rinsho Byori 2005)
    985. Telomerase activity and expression of the telomerase catalytic subunit gene in non-small cell lung cancer: correlation with decreased apoptosis and clinical prognosis. (PubMed id 11776132)9 Wang J....Liang L. (Chin. Med. J. 2000)
    986. Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation. (PubMed id 15236314)9 Liu L....Tollefsbol T.O. (amp 2004)
    987. [Measurement of telomerase activity and telomerase reverse transcriptase expression in gastric fluid and tissue for early diagnosis of stomach cancer]. (PubMed id 14532739)9 Lee H.J....Min Y.I. (Korean J Gastroenterol 2003)
    988. The correlation of TERT expression with c-myc expression in cervical cancer. (PubMed id 11368876)9 Sagawa Y....Takayama M. (Cancer Lett. 2001)
    989. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas. (PubMed id 9914776)9 Yasui W....Tahara E. (Jpn. J. Cancer Res. 1998)
    990. Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer. (PubMed id 17130181)9 Mavrogiannou E....Lianidou E.S. (Clin. Chem. 2007)
    991. [Expressions of telomerase reverse transcriptase and vascular endothelial growth factor and their correlation in prostate cancer]. (PubMed id 16281501)9 Li X....Tang J. (Zhonghua Nan Ke Xue 2005)
    992. Correlation between the expression of telomerase reverse transcriptase and proliferative activity in breast cancer cells using an immunocytochemical restaining method. (PubMed id 14629300)9 Ikeda S....Koike M. (Pathol. Int. 2003)
    993. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. (PubMed id 16556873)9 Ogawa D....Bruemmer D. (Circ. Res. 2006)
    994. Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus. (PubMed id 14514679)9 Ullas K.S. and Rao M.R. (J. Biol. Chem. 2003)
    995. Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression. (PubMed id 12941894)9 McMurray H.R. and McCance D.J. (J. Virol. 2003)
    996. Telomerase reverse transcriptase (TERT) expression in canine mammary tissues: a specific marker for malignancy? (PubMed id 19331168)9 Zavlaris M....Papaioannou N. (Anticancer Res. 2009)
    997. Short hairpin ribonucleic acid targeting the telomerase catalytic unit of messenger ribonucleic acid significantly limits the growth of laryngeal squamous cell carcinoma in nude mice. (PubMed id 17592663)9 Zhou X.H....Tao Z.Z. (J Laryngol Otol 2008)
    998. Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. (PubMed id 17381549)9 Westin E.R....Klingelhutz A.J. (Aging Cell 2007)
    999. Immunity against breast cancer by TERT DNA vaccine primed with chemokine CCL21. (PubMed id 17318199)9 Yamano T....Hoon D.S. (Cancer Gene Ther. 2007)
    1000. Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. (PubMed id 15731105)9 O'Connor C.M....Collins K. (J. Biol. Chem. 2005)
    1001. High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. (PubMed id 16172460)9 Dome J.S....Breslow N.E. (J. Clin. Oncol. 2005)
    1002. Human telomerase reverse transcriptase gene expression and the surgical management of suspicious thyroid tumors. (PubMed id 15355904)9 Umbricht C.B....Zeiger M.A. (Clin. Cancer Res. 2004)
    1003. Evolution of programmed ribosomal frameshifting in the TERT genes of Euplotes. (PubMed id 15461427)9 MAPllenbeck M....Klobutcher L.A. (J. Mol. Evol. 2004)
    1004. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. (PubMed id 15282303)9 Chiang Y.J....Hodes R.J. (Mol. Cell. Biol. 2004)
    1005. Effect of TERT and ATM on gene expression profiles in human fibroblasts. (PubMed id 14978791)9 Baross A....Lansdorp P.M. (amp 2004)
    1006. Molecular cloning of the feline telomerase reverse transcriptase (TERT) gene and its expression in cell lines and normal tissues. (PubMed id 12808208)9 Yazawa M....Tsujimoto H. (J. Vet. Med. Sci. 2003)
    1007. Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. (PubMed id 12196919)9 Wei R. and Younes M. (Hum. Pathol. 2002)
    1008. Emerging roles for telomerase in neuronal development and apoptosis. (PubMed id 11169608)9 Mattson M.P. and Klapper W. (J. Neurosci. Res. 2001)
    1009. Expression of telomerase reverse transcriptase mRNA and its quantitative analysis in human endometrial cancer. (PubMed id 11078809)9 Oshita T....Ohama K. (Int. J. Oncol. 2000)
    1010. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach. (PubMed id 10429648)9 Yasui W....Tahara E. (Jpn. J. Cancer Res. 1999)
    1011. Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells. (PubMed id 19047367)9 HrdlickovA! R....Bose H.R. (Mol. Cell. Biol. 2009)
    1012. Canis familiaris telomerase reverse transcriptase undergoes alternative splicing. (PubMed id 18836773)9 Angelopoulou K....Vlemmas I. (Mamm. Genome 2008)
    1013. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. (PubMed id 18482052)9 Cao Y....Reddel R.R. (Cancer Sci. 2008)
    1014. Effects of Shugansanjie Tang on matrix metalloproteinases 1, 3 and 9 and telomerase reverse transcriptase expression in human breast cells in vitro. (PubMed id 17913446)9 Loo W.T....Chou J.W. (amp 2007)
    1015. Expression of human telomerase reverse transcriptase and correlation with telomerase activity in placentas with and without intrauterine growth retardation. (PubMed id 16521673)9 Izutsu T....Sugiyama T. (Acta Obstet Gynecol Scand 2006)
    1016. Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity. (PubMed id 16806743)9 Chang H. and Delany M.E. (Gene 2006)
    1017. [Expression and significance of TERT and c-Myc oncogene protein product on cholesteatoma epithelium]. (PubMed id 16001896)9 Zhang F....Chen S. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005)
    1018. Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT. (PubMed id 15893283)9 Gulmann C....Kay E. (Dig Liver Dis 2005)
    1019. Cloning and expression of the reverse transcriptase component of pufferfish (Fugu rubripes) telomerase. (PubMed id 15961261)9 Yap W.H....Venkatesh B. (Gene 2005)
    1020. Expression pattern of telomerase reverse transcriptase in rectal carcinoma predicts tumor radiosensitivity, local recurrence and disease-free survival. (PubMed id 16001613)9 Komuro Y....Nagawa H. (Hepatogastroenterology 2005)
    1021. Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). (PubMed id 15225880)9 Nasir L....Argyle D.J. (Gene 2004)
    1022. The chicken telomerase reverse transcriptase (chTERT): molecular and cytogenetic characterization with a comparative analysis. (PubMed id 15363846)9 Delany M.E. and Daniels L.M. (Gene 2004)
    1023. EWS/ETS fusions activate telomerase in Ewing's tumors. (PubMed id 14678994)9 Takahashi A....Shindoh M. (Cancer Res. 2003)
    1024. Functional analysis of conserved residues in the putative &quot;finger&quot; domain of telomerase reverse transcriptase. (PubMed id 11581271)9 Bosoy D. and Lue N.F. (J. Biol. Chem. 2001)
    1025. Telomerase activity and telomerase reverse transciptase (TERT) expression in ameloblastomas. (PubMed id 11302243)9 Kumamoto H....Ooya K. (amp 2001)
    1026. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. (PubMed id 10983995)9 Bryan T.M....Cech T.R. (Mol. Cell 2000)
    1027. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. (PubMed id 10854032)9 Fu W....Mattson M.P. (J. Mol. Neurosci. 2000)
    1028. Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2. (PubMed id 8961924)9 Kundu T.K. and Rao M.R. (Biochemistry 1996)
    1029. Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC. (PubMed id 19558498)9 Gourronc F.A....Klingelhutz A.J. (Exp. Dermatol. 2010)
    1030. Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease. (PubMed id 19788441)9 Shan S.J....Chen H.D. (J. Cutan. Pathol. 2010)
    1031. Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent. (PubMed id 20211239)9 BA1chner N....Haendeler J. (Exp. Gerontol. 2010)
    1032. Cancer cell targeting with mouse TERT-specific group I intron of Tetrahymena thermophila. (PubMed id 19809268)9 Ban G....Lee S.W. (J. Microbiol. Biotechnol. 2009)
    1033. NOLA1 gene mutations in acquired aplastic anemia. (PubMed id 18989882)9 Pigullo S....Dufour C. (amp 2009)
    1034. [Short hairpin RNA silencing of vascular endothelial growth factor, telomerase reverse transcriptase, and Bcl-xl expression in human laryngeal squamous carcinoma xenografted in nude mice]. (PubMed id 19159530)9 Wang Y....Tao Z.Z. (Zhonghua Bing Li Xue Za Zhi 2008)
    1035. TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. (PubMed id 18252230)9 Savage S.A....Alter B.P. (Am. J. Hum. Genet. 2008)
    1036. Application of combination of short hairpin RNA segments for silencing VEGF, TERT and Bcl-xl expression in laryngeal squamous carcinoma. (PubMed id 18367874)9 Wang Y....Liu J.P. (amp 2008)
    1037. Expression of telomeric repeat binding factor 1 protein in nonsmall cell lung cancer with human telomerase reverse transcriptase positive. (PubMed id 18397896)9 Hu Jian ....Zhou X.L. (Int. J. Surg. Pathol. 2008)
    1038. Detection of telomerase in urine by 3 methods: evaluation of diagnostic accuracy for bladder cancer. (PubMed id 17644139)9 Eissa S....Tash F.M. (J. Urol. 2007)
    1039. Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation. (PubMed id 16278815)9 ClAcment G....Benhattar J. (J. Pathol. 2006)
    1040. Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma. (PubMed id 16168519)9 Lie-A-Ling M....Bosma P.J. (J. Hepatol. 2006)
    1041. Hypoxia induces telomerase reverse transcriptase (TERT) gene expression in non-tumor fish tissues in vivo: the marine medaka (Oryzias melastigma) model. (PubMed id 16961934)9 Yu R.M....Au D.W. (BMC Mol. Biol. 2006)
    1042. The structure and function of telomerase reverse transcriptase. (PubMed id 16756500)9 Autexier C. and Lue N.F. (Annu. Rev. Biochem. 2006)
    1043. Conditional telomerase induction causes proliferation of hair follicle stem cells. (PubMed id 16107853)9 Sarin K.Y....Artandi S.E. (Nature 2005)
    1044. Demonstration of human telomerase reverse transcriptase by in situ hybridization in lung carcinoma. (PubMed id 15547742)9 Fukushima M....Takubo K. (Oncol. Rep. 2004)
    1045. Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade. (PubMed id 15590986)9 Du B....Kurachi H. (J. Endocrinol. 2004)
    1046. Telomerase reverse transcriptase subunit expression is associated with chondrosarcoma malignancy. (PubMed id 15346061)9 Martin J.A....Buckwalter J.A. (Clin. Orthop. Relat. Res. 2004)
    1047. Characterization of Oryza sativa telomerase reverse transcriptase and possible role of its phosphorylation in the control of telomerase activity. (PubMed id 15527966)9 Oguchi K....Takahashi H. (Gene 2004)
    1048. Telomerase expression predicts unfavorable outcome in osteosarcoma. (PubMed id 15365076)9 Sanders R.P....Dome J.S. (J. Clin. Oncol. 2004)
    1049. Expression of telomerase activity, human telomerase RNA, and telomerase reverse transcriptase in gastric adenocarcinomas. (PubMed id 12861067)9 Yoo J....Kang C.S. (Mod. Pathol. 2003)
    1050. The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. (PubMed id 12853623)9 Huard S....Autexier C. (Nucleic Acids Res. 2003)
    1051. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. (PubMed id 11809815)9 Moriarty T.J....Autexier C. (Mol. Cell. Biol. 2002)
    1052. Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma. (PubMed id 11918915)9 WA1rl P....Taubert H. (Lancet 2002)
    1053. Genetic alterations in cervical carcinomas: frequent low-level amplifications of oncogenes are associated with human papillomavirus infection. (PubMed id 12216070)9 Zhang A....Wallin K.L. (Int. J. Cancer 2002)
    1054. c-Myc-mediated regulation of telomerase activity is disabled in immortalized cells. (PubMed id 11402027)9 Drissi R....Cleveland J.L. (J. Biol. Chem. 2001)
    1055. Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma. (PubMed id 11407973)9 Villa R....Zaffaroni N. (J. Invest. Dermatol. 2001)
    1056. Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. (PubMed id 10973321)9 Nair S.K....Gilboa E. (Nat. Med. 2000)
    1057. Template definition by Tetrahymena telomerase reverse transcriptase. (PubMed id 10944124)9 Miller M.C....Collins K. (EMBO J. 2000)
    1058. Telomerase and HER-2/neu as targets of genetic cancer vaccines in dogs. (PubMed id 19944791)9 Peruzzi D....Aurisicchio L. (Vaccine 2010)
    1059. Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. (PubMed id 19483728)9 Yuan J....MacKenzie K.L. (Oncogene 2009)
    1060. [Telomere length measurement of 10 Chinese patients with bone marrow failure syndrome.]. (PubMed id 20137312)9 Liu B....Zhao Y.Q. (Zhonghua Xue Ye Xue Za Zhi 2009)
    1061. Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status. (PubMed id 19627485)9 Saini N....Rajwanshi A. (Liver Int. 2009)
    1062. Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients. (PubMed id 19036115)9 Kirwan M....Dokal I. (Br. J. Haematol. 2009)
    1063. Preventive vaccination with telomerase controls tumor growth in genetically engineered and carcinogen-induced mouse models of cancer. (PubMed id 19047167)9 Mennuni C....Scarselli E. (Cancer Res. 2008)
    1064. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. (PubMed id 17967894)9 Liu X....Martinez E. (Mol. Cell. Biol. 2008)
    1065. [Effects of human telomerase reverse transcriptase promoter and survivin promoter in targeted tumor gene therapy]. (PubMed id 18642790)9 Zhang Y....Zheng D.X. (Zhonghua Yi Xue Za Zhi 2008)
    1066. Dyskeratosis congenita: a genetic disorder of many faces. (PubMed id 18005359)9 Kirwan M. and Dokal I. (Clin. Genet. 2008)
    1067. Photodynamic effect in medulloblastoma: downregulation of matrix metalloproteinases and human telomerase reverse transcriptase expressions. (PubMed id 18167600)9 Chu E.S....Yow C.M. (amp 2008)
    1068. Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. (PubMed id 18317213)9 Branca M....SyrjAonen K. (Int. J. Gynecol. Pathol. 2008)
    1069. [Inhibitory effect of RNAi targeting human telomerase reverse transcriptase against human hepatocellular carcinoma cells]. (PubMed id 18753050)9 Li H....Chen G.H. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    1070. Telomere maintenance and human bone marrow failure. (PubMed id 18239083)9 Calado R.T. and Young N.S. (Blood 2008)
    1071. Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3. (PubMed id 17615260)9 Chau M.N....Banerjee P.P. (Carcinogenesis 2007)
    1072. Human diseases of telomerase dysfunction: insights into tissue aging. (PubMed id 17913752)9 Garcia C.K....Shay J.W. (Nucleic Acids Res. 2007)
    1073. The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium. (PubMed id 17290039)9 van den Berg R.M....Smit E.F. (Am. J. Respir. Crit. Care Med. 2007)
    1074. Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells. (PubMed id 18021178)9 Folini M....Zaffaroni N. (Cell Prolif. 2007)
    1075. Effect of RNA interference targeting human telomerase reverse transcriptase on telomerase and its related protein expression in nasopharyngeal carcinoma cells. (PubMed id 17156515)9 Wang Y....Tao Z.Z. (J Laryngol Otol 2007)
    1076. Methylation profiling of mesothelioma using real-time methylation-specific PCR: a pilot study. (PubMed id 17636483)9 Pu R.T....O'Leary T.J. (Diagn. Cytopathol. 2007)
    1077. Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue. (PubMed id 16515751)9 Bialkowska-Hobrzanska H....Razvi H. (Can J Urol 2006)
    1078. [The animal research of recombinant adenovirus controlled by human telomerase reverse transcriptase promoter in the treatment of human prostate cancer]. (PubMed id 17147886)9 Zhang Y....Liu K.L. (Zhonghua Wai Ke Za Zhi 2006)
    1079. Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma. (PubMed id 16489651)9 Liu J.L....Zhang G.N. (World J. Gastroenterol. 2006)
    1080. Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis. (PubMed id 15860868)9 DA'mont J....Vauthey J.N. (J. Clin. Oncol. 2005)
    1081. Immunohistochemical detection of human telomerase reverse transcriptase (hTERT) and c-kit in serous ovarian carcinoma: a clinicopathologic study. (PubMed id 16005054)9 Brustmann H. (Gynecol. Oncol. 2005)
    1082. Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. (PubMed id 15951564)9 Wooten L.G. and Ogretmen B. (J. Biol. Chem. 2005)
    1083. Immortalization of cementoblast progenitor cells with Bmi-1 and TERT. (PubMed id 15619669)9 Saito M....Teranaka T. (J. Bone Miner. Res. 2005)
    1084. Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptase. (PubMed id 15342398)9 Sun B....Hornsby P.J. (Cancer Res. 2004)
    1085. Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter. (PubMed id 15161713)9 Jacob D....Fang B. (Clin. Cancer Res. 2004)
    1086. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. (PubMed id 15079066)9 Erdmann N....Harrington L. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    1087. Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity. (PubMed id 15665594)9 Natarajan S....Corey D.R. (Oligonucleotides 2004)
    1088. Visualization of intrathoracically disseminated solid tumors in mice with optical imaging by telomerase-specific amplification of a transferred green fluorescent protein gene. (PubMed id 15342413)9 Umeoka T....Fujiwara T. (Cancer Res. 2004)
    1089. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. (PubMed id 15569975)9 Friedrich M.G....Liang G. (Clin. Cancer Res. 2004)
    1090. Telomerase activity and telomerase catalytic subunit in hepatocellular carcinoma. (PubMed id 15143919)9 Lee C.M....Cho C.L. (Hepatogastroenterology 2004)
    1091. Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas. (PubMed id 15067344)9 Saito M....Ohnishi T. (Int. J. Oncol. 2004)
    1092. Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes. (PubMed id 15364800)9 Rossi M.L....Ardissino D. (Circulation 2004)
    1093. [Clinical significance of human telomerase reverse transcriptase in patients with colon cancer]. (PubMed id 15566667)9 Li L.R....Chen G. (Ai Zheng 2004)
    1094. Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. (PubMed id 15143073)9 Gertler R....Siewert J.R. (J. Clin. Oncol. 2004)
    1095. [Expression of human telomerase reverse transcriptase and bcl-2 in ameloblastoma]. (PubMed id 14732976)9 Wang J....Wang Z. (Hua Xi Kou Qiang Yi Xue Za Zhi 2003)
    1096. [Study on expression of ING1, human telomerase reverse transcriptase and telomerase-associated protein 1 genes in human gliomas]. (PubMed id 12882685)9 Yu S.Z....An T.L. (Zhonghua Bing Li Xue Za Zhi 2003)
    1097. Telomerase promoter-driven cancer gene therapy. (PubMed id 14508082)9 Gu J. and Fang B. (amp 2003)
    1098. [Expression of telomerase reverse transcriptase in premalignant esophageal squamous dysplasia]. (PubMed id 14575609)9 Yu H.P....Lu W.H. (Zhonghua Liu Xing Bing Xue Za Zhi 2003)
    1099. Detection of telomerase status by semiquantitative and in situ assays, and by real-time reverse transcription-polymerase chain reaction (telomerase reverse transcriptase) assay in bladder carcinomas. (PubMed id 12656916)9 Longchampt E....Lidereau R. (BJU Int. 2003)
    1100. Template boundary definition in Tetrahymena telomerase. (PubMed id 11850404)9 Lai C.K....Collins K. (amp 2002)
    1101. Demonstration of human telomerase reverse transcriptase in human colorectal carcinomas by in situ hybridization. (PubMed id 11743637)9 Kammori M....Takubo K. (Int. J. Oncol. 2002)
    1102. Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma. (PubMed id 12408525)9 Oka S....Chayama K. (Scand. J. Gastroenterol. 2002)
    1103. The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. (PubMed id 12479216)9 Grand C.L....Bearss D.J. (Mol. Cancer Ther. 2002)
    1104. Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients. (PubMed id 11753470)9 Schrader M....Miller K. (Asian J. Androl. 2001)
    1105. [Expression of telomerase reverse transcriptase and its relationship with tumor suppressor gene p53 in HCC]. (PubMed id 11509149)9 Dai D....Ling Y. (Zhonghua Gan Zang Bing Za Zhi 2001)
    1106. HPV detection and measurement of HPV-16, telomerase, and survivin transcripts in colposcopy clinic patients. (PubMed id 11304848)9 Lanham S....Watt P. (J. Clin. Pathol. 2001)
    1107. Quantitative measurement of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas. (PubMed id 11911285)9 Luzar B....Gale N. (Anticancer Res. 2001)
    1108. Clinical evaluation of human telomerase catalytic subunit in bladder washings from patients with bladder cancer. (PubMed id 11689147)9 Fukui T....Okuyama A. (Mol Urol 2001)
    1109. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas. (PubMed id 12007281)9 Matsutani N....Yasui W. (Pathobiology 2001)
    1110. c-Myc and Sp1/3 are required for transactivation of hamster telomerase catalytic subunit gene promoter. (PubMed id 11562751)9 Park N.H....Park N.H. (Int. J. Oncol. 2001)
    1111. Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas. (PubMed id 11230706)9 Kumaki F....Torikata C. (Hum. Pathol. 2001)
    1112. Human dendritic cells transfected with renal tumor RNA stimulate polyclonal T-cell responses against antigens expressed by primary and metastatic tumors. (PubMed id 11309297)9 Heiser A....Vieweg J. (Cancer Res. 2001)
    1113. Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component. (PubMed id 10811633)9 Masutomi K....Murakami S. (J. Biol. Chem. 2000)
    1114. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. (PubMed id 10983983)9 Mitchell J.R. and Collins K. (Mol. Cell 2000)
    1115. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. (PubMed id 11034071)9 Gu J....Fang B. (Cancer Res. 2000)
    1116. Telomeres, telomerase, and myc. An update. (PubMed id 10648922)9 Cerni C. (Mutat. Res. 2000)
    1117. Up-regulation of telomerase in primary cultured rat hepatocytes. (PubMed id 10423530)9 Nozawa K....Yoshida S. (J. Biochem. 1999)
    1118. TGF-beta induces telomerase-dependent pancreatic tumor cell cycle arrest. (PubMed id 20138964)9 Cassar L....Liu J.P. (Mol. Cell. Endocrinol. 2010)
    1119. The choice of the antigen in the dendritic cell-based vaccine therapy for prostate cancer. (PubMed id 19954892)9 Matera L. (Cancer Treat. Rev. 2010)
    1120. Repression of human telomerase reverse transcriptase using artificial zinc finger transcription factors. (PubMed id 20145034)9 Sohn J.H....Kim H.W. (Mol. Cancer Res. 2010)
    1121. Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. (PubMed id 20171193)9 Ren H....Hao J. (Biochem. Biophys. Res. Commun. 2010)
    1122. A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors. (PubMed id 19935775)9 Nemunaitis J....Fujiwara T. (Mol. Ther. 2010)
    1123. Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. (PubMed id 20096072)9 Svec J....PA!cha J. (Int J Exp Pathol 2010)
    1124. Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase. (PubMed id 19995569)9 Indran I.R....Pervaiz S. (Mol. Aspects Med. 2010)
    1125. Prevention of senescence progression in reversibly immortalized human ensheathing glia permits their survival after deimmortalization. (PubMed id 19935779)9 GarcA-a-Escudero V....Lim F. (Mol. Ther. 2010)
    1126. TCEAL7, a putative tumor suppressor gene, negatively regulates NF- kappaB pathway. (PubMed id 19966855)9 Rattan R....Shridhar V. (Oncogene 2010)
    1127. [Tumor-targeted human telomerase reverse transcriptase promoter/tk gene therapy against human nasopharyngeal carcinoma cells in vitro]. (PubMed id 20423828)9 Xu F....Guo M.H. (Nan Fang Yi Ke Da Xue Xue Bao 2010)
    1128. Ets2 transcription factor, telomerase activity and breast cancer. (PubMed id 19566835)9 Dwyer J.M. and Liu J.P. (amp 2010)
    1129. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. (PubMed id 19577445)9 Huang S.T....Pang J.H. (Phytomedicine 2010)
    1130. [Effects of differentially expressed proteins in hepatocellular carcinoma cell treated by different telomerase inhibitors]. (PubMed id 20459048)9 Wei X....Zheng W. (Wei Sheng Yan Jiu 2010)