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TERT Gene

protein-coding GIFtS: 71

GC05M001306

telomerase reverse transcriptase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.7.49 ^³
EST2 ^¹, ², ³, ⁵
HEST2 ^³
TCS1 ^¹, ², ³, ⁵
TP2 ^¹, ², ³
TRT ^¹, ², ³
hEST2 ^¹, ²

Descriptions
Telomerase catalytic subunit ^², ³
Telomerase-associated protein 2 ^³
telomerase reverse transcriptase ^²

External Ids
HGNC: 11730¹
Entrez Gene: 7015²
UniProtKB: O14746³
Ensembl: ENSG00000164362⁷

Search outside databases for aliases for TERT gene

Previous GC identifers: GC05P001643 GC05M001282

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TERT:

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the

telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase

activity, encoded by this gene, and an RNA component which serves as a template for the telomere

repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in

postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of

telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest

that telomerase also participates in chromosomal repair, since de novo synthesis of telomere

repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different

isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of

some variants has not been determined. Alternative splicing at this locus is thought to be one

mechanism of regulation of telomerase activity. [provided by RefSeq]

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746

Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome

termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple

sequence repeats to chromosome ends by copying a template sequence within the RNA component of the

enzyme

Gene Wiki entry for TERT (Telomerase_reverse_transcriptase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TERT gene

Entrez Gene cytogenetic band: 5p15.33 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.33

TERT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M001306: (about GC identifiers)

Start:	1,306,282 bp from pter
End:	1,348,162 bp from pter
Size:	41,881 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746 (See protein sequence)

Recommended Name: Telomerase reverse transcriptase

Size: 1132 amino acids; 126997 Da

Subunit: Catalytic subunit of the telomerase holoenzyme complex at least composed of TERT, DKC1,

WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).

Interacts with PINX1 and MCRS1

Subcellular location: Nucleus. Telomere

PDB structures from and Proteopedia :

2BCK (3D)

Secondary accessions: O14783 Q2XS35 Q8N6C3 Q8NG46

Alternative splicing: 3 isoforms: O14746-1 O14746-2 O14746-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_937983.2 NP_937986.1

ENSEMBL proteins:

ENSP00000296820 ENSP00000309572 ENSP00000334346

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Telomerase)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000781	chromosome, telomeric region	IC	12135483
GO:0000783	nuclear telomere cap complex	IC	15632080
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	15060173 15189140
GO:0005694	chromosome	IEA	--

About this table

Antibodies for TERT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TERT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Telomerase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TERT)
	Novus Biologicals Antibodies for TERT

Assays for TERT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14746

ProtoNet protein and cluster: O14746

1 Blocks protein family: IPB003545 Telomere reverse transcriptase signature

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746

Similarity: Belongs to the reverse transcriptase family. Telomerase subfamily

Similarity: Contains 1 reverse transcriptase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TERT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TERT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003219

Applied Biosystems Silencer® siRNAs for TERT

Sigma-Aldrich siRNA and siRNA Panels for TERT

Sigma-Aldrich shRNA for TERT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_198253
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_198253
untagged cDNA clones in CMV expression vector (see all 2): NM_198253

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003219

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746

Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome

termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple

sequence repeats to chromosome ends by copying a template sequence within the RNA component of the

enzyme

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

Enzyme Number (IUBMB): EC 2.7.7.49

Genatlas biochemistry entry for TERT:

telomerase,catalytic subunit,yeast Est2 homolog,100kDa,involved in telomere maintenance,putative

up-regulated c-Myc target gene,protein activity deleted in cancer,repressed in normal tissues

6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tert):

cellular	endocrine/exocrine gland	homeostasis/metabolism	normal	reproductive system
tumorigenesis

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003721	telomeric template RNA reverse transcriptase activity	TAS	14991929
GO:0005515	protein binding	IPI	18358808
GO:0016740	transferase activity	IEA	--
GO:0016779	nucleotidyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TERT

5/106 Interacting proteins for TERT (O14746^{1, 2} ENSP00000309572³) via UniProtKB, MINT, and/or STRING (see all 106 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKT1	P31749², ENSP00000270202³	MINT-6742762 STRING (score=.999)
RUVBL1	Q9Y265¹, ENSP00000318297³	EBI-1772203, EBI-353675 STRING (score=.779)
HSP90AA2	ENSP00000335153³	STRING (score=.999)
DKC1	ENSP00000358563³	STRING (score=.998)
ENSG00000104637	ENSP00000318966³	STRING (score=.997)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000723	telomere maintenance	TAS	12135483
GO:0006916	anti-apoptosis	IMP	10449030
GO:0007004	telomere maintenance via telomerase	IMP	9454332
GO:0010149	senescence	IMP	9454332
GO:0022616	DNA strand elongation	IDA	16043710

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for TERT

Sigma-Aldrich Small Molecules for TERT:

Inhibitor

Compounds for TERT available from Tocris Bioscience

Compound	Action	CAS number
BIBR 1532	Selective telomerase inhibitor	[321674-73-1]
Costunolide	Inhibitor of human telomerase activity	[553-21-9]

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10/18 Novoseek chemical compound relationships for TERT gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	62.08	7	12007281 (2), 11494028 (1), 19419704 (1), 18669893 (1)
lipofectamine	39.27	1	17495775 (1)
oligonucleotide	18.72	4	12838868 (1), 17991312 (1), 12519411 (1)
wortmannin	5.85	2	16093915 (1)
zinc	3.11	5	8961924 (2), 15983032 (1)
cdcs	1.47	2	16953888 (1), 12629597 (1)
nitric oxide	1.17	3	17943236 (1), 11679409 (1), 12201830 (1)
oxygen	0.29	4	14963003 (2), 12824159 (1), 17943236 (1)
calcium	0.22	3	15375555 (1), 17720143 (1), 17197440 (1)
lipid	0.07	1	18802925 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TERT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TERT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003219

Sigma-Aldrich siRNA and siRNA Panels for TERT

Sigma-Aldrich shRNA for TERT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_198253 NM_198255

REFSEQ mRNAs for TERT gene (2 alternative transcripts):

NM_198253.2 NM_198255.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_198253 NM_198255

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_198253
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_198253
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_198253

Additional cDNA sequence:

AB085628.1 AF015950.1 AF018167.1 BC062321.1

3 DOTS entries:

DT.108983 DT.101961620 DT.40268927

24/29 AceView cDNA sequences (see all 29 ):

AF015950 AB086379 NM_198253 NM_198255 NM_003219 AW276315 AX810038 NM_198254

AB085628 AB086950 AI824948 BC062321 AX810036 BE514188 AA299878 BM453198

AX810043 AA281296 AA311750 AW270031 AF018167 BM824748 BE514070 AA811084

highest scoring ESTs for TERT:

AF015950 AB085628 AF018167 AA281296 AA748707 AA811084 AB086379 AB086950 AI824948 AW270031

Unigene Cluster for TERT:

Telomerase reverse transcriptase

Hs.492203 [show with all ESTs]

Unigene Representative Sequence: AF018167

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TERT

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b
SP1:							-
SP2:							-																				-
SP3:							-												-		-						-
SP4:							-								-				-		-						-
SP5:																			-		-

About this scheme

ECgene alternative splicing isoforms for TERT

3 Ensembl transcripts including schematic representations:

ENST00000296820 ENST00000310581 ENST00000334602

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TERT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TERT

¹ / ² / ³

4 probe-sets matching TERT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1869_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF015950	1.00	1.00	1.00	1
207199_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003219	0.40	1.00	0.76	1
207199_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555271_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TERT for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCGGCTGAA

SOURCE GeneReport for Unigene cluster: Hs.492203
Expression variation in blood from EXPOLDB for TERT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TERT gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TERT¹	--	telomerase reverse transcriptase	78.41(n) 74.67(a)	403412 XM_846571.1 XP_851664.1
chimpanzee (Pan troglodytes)	TERT¹	--	telomerase reverse transcriptase	98(n) 97.44(a)	471443 XM_001141663.1 XP_001141663.1
cow (Bos taurus)	TERT¹	--	telomerase reverse transcriptase	77.71(n) 72.1(a)	518884 NM_001046242.1 NP_001039707.1
rat (Rattus norvegicus)	Tert¹	--	telomerase reverse transcriptase	70.69(n) 64.63(a)	301965 NM_053423.1 NP_445875.1
mouse (Mus musculus)	Tert^{1, 5}	13 (43.00 cM)⁵	telomerase reverse transcriptase^{1, 5}	70.97(n)¹ 64.53(a)¹	21752¹ NM_009354.1¹ NP_033380.1¹ AF029235⁵ AF051911⁵ (see all 12)

About this table Species with no ortholog for TERT

ENSEMBL Gene Tree for TERT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/659 NCBI SNPs in TERT are shown (see all 659 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 233)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2853691^1,2	A,C,F,H	1305950(-)	`TGGCCA/GGGGTG`	2	--	ng5¹		9	EU EA WA NS	602
	rs2735940^1,2	A,C,F	1349486(-)	`CGACCT/CGTAAT`	2	--	ng3¹		10	MN CSAM EA NS	592
	rs2736109^1,2	A,C,F	1349759(-)	`TCAGCG/AATCTT`	2	--	ng3¹		10	MN CSAM EA NS	596
	rs5031049^1,2	C,F,H	1306780(-)	`CTCTAC/TGTCCC`	2	--	ut3¹ ese³		14	MN CSAM EA EU WA NS	1004
	rs7712562^1,2	C,F,H	1349072(+)	`GGGCAG/ACCTCG`	2	--	ng3¹		14	MN CSAM EA EU WA NS	908
	rs2853690^1,2	A,C,F	1306744(-)	`AGGCCC/TGCACC`	2	--	ut3¹ ese³		10	MN CSAM EA NS	588
	rs33985695^1,2	C,F	1349653(-)	`ATTGTG/ATTTTC`	2	--	ng3¹		10	MN CSAM EA NS	596
--	rs33987166^1,2	C,F	1349758(-)	`CAGCGA/GTCTTC`	2	--	ng3¹		10	MN CSAM EA NS	594
	rs33977403^1,2	C,F	1349727(-)	`TCCTCG/ACCATG`	2	--	ng3¹		10	MN CSAM EA NS	594
	rs33958877^1,2	C,F	1348682(-)	`ACGTCC/AGGCAT`	2	--	ng3¹		10	MN CSAM EA NS	572

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HapMap Linkage Disequilibrium images for TERT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 187270 disorders: 609135 178500 127550

UniProtKB/Swiss-Prot: TERT_HUMAN, O14746

Activation of telomerase has been implicated in cell immortalization and cancer cell

pathogenesis

Defects in TERT are associated with susceptibilty to aplastic anemia (AA) [MIM:609135]. AA

is a rare disease in which the reduction of the circulating blood cells results from damage to the

stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune

attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic

stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress

hematopoiesis

Genetic variations in TERT are associated with coronary artery disease (CAD)

Defects in TERT are a cause of dyskeratosis congenita autosomal dominant (ADDKC)

[MIM:127550]; also known as dyskeratosis congenita Scoggins type. ADDKC is a rare, progressive

bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation,

nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow

failure, infections, fatal pulmonary complications, or malignancy

Defects in TERT increases susceptibility to idiopathic pulmonary fibrosis [MIM:178500].

Idiopathic pulmonary fibrosis is an adult-onset, lethal, scarring lung disease of unknown

etiology. Its clinical features are shortness of breath, radiographically evident diffuse

pulmonary infiltrates, and varying degrees in inflammation, fibrosis, or both on biopsy. It is

rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and

endstage lung disease

10/96 Novoseek disease relationships for TERT gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dyskeratosis congenita	82.03	8	15885610 (2), 17454774 (1), 17468339 (1), 19415813 (1) (see all 8)
dyskeratosis congenita, autosomal dominant	78.82	6	16247010 (1), 17392301 (1), 18460650 (1), 17875000 (1) (see all 5)
cancer	72.85	190	11934015 (4), 14532739 (4), 11034071 (2), 12218171 (2) (see all 99)
tumors	69.18	226	10973321 (5), 17130181 (5), 18204433 (5), 17656250 (4) (see all 99)
hepatocellular carcinoma	56.00	28	18753050 (2), 11944954 (2), 15143919 (2), 17244456 (1) (see all 24)
laryngeal squamous cell carcinoma	55.36	12	17592663 (2), 17219990 (2), 15823813 (2), 11911285 (2) (see all 7)
benign meningioma	49.76	2	17227292 (1), 17415213 (1)
precancerous lesions	47.57	8	10429648 (2), 14716817 (2), 11906620 (1), 10779229 (1) (see all 5)
neoplastic transformation	44.48	4	11454711 (1), 10473565 (1), 17827040 (1)
anemia aplastic	42.64	12	15814878 (2), 15885610 (2), 17625368 (1), 17640862 (1) (see all 8)

About this table

GeneTests: TERT

Familial Pulmonary Fibrosis

Human Gene Mutation Database: TERT
Genetic Association Database: TERT
Human Genome Epidemiology Navigator: TERT (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1072 PubMed articles for TERT gene (see all 1072 ):

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. (PubMed id 15814878)^{1, 3, 4, 6} Yamaguchi H.... Young N.S. (2005)
Telomerase catalytic subunit homologs from fission yeast and human. (PubMed id 9252327)^{2, 3, 4} Nakamura T.M.... Cech T.R. (1997)
Adult-onset pulmonary fibrosis caused by mutations in telomerase. (PubMed id 17460043)^{1, 3, 4} Tsakiri K.D.... Garcia C.K. (2007)
Human telomerase contains evolutionarily conserved catalytic and structural subunits. (PubMed id 9389643)^{1, 3, 4} Harrington L.... Robinson M.O. (1997)
hEST2, the putative human telomerase catalytic subunit gene, is up- regulated in tumor cells and during immortalization. (PubMed id 9288757)^{1, 3, 4} Meyerson M.... Weinberg R.A. (1997)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Coronary artery disease and a functional polymorphism of hTERT. (PubMed id 16890917)^{3, 4} Matsubara Y.... Ikeda Y. (2006)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)
Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines. (PubMed id 14654914)^{3, 4} Nagao K.... Hisatomi H. (2004)
Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PubMed id 15044100)^{3, 4} Song H....Zhao M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7015	HGNC: 11730	AceView: TERT	Ensembl:ENSG00000164362	euGenes: HUgn7015
ECgene: TERT	H-InvDB: TERT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TERT	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tert/

Licensable Technologies for TERT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TERT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TERT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TERT		Antibodies for TERT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TERT		Small molecules for TERT
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (TERT)
	Chimera RNAi (TERT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Telomerase)
	Antibodies (Telomerase)

Search OriGene for TERT

Tocris compounds for TERT

	Drugs for TERT
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TERT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TERT Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TERT Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for TERT

Summaries
for TERT

Genomic Location
for TERT

Proteins
for TERT

Protein Domains/
Families
for TERT

Gene Function
for TERT

Pathways & Interactions
for TERT

Drugs & Compounds
for TERT

Transcripts
for TERT

Expression
for TERT

Orthologs
for TERT

Paralogs
for TERT

SNPs/Variants
for TERT

Disorders & Mutations
for TERT

Medical News
for TERT

Publications
for TERT

Search for TERT

Genome Databases showing TERT

Other Databases showing TERT

Specialized Databases showing TERT

Licensable Technologies
for TERT

Services
for TERT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TERT Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor TERT

Summariesfor TERT

Genomic Locationfor TERT

Proteinsfor TERT

Protein Domains/Familiesfor TERT

Gene Functionfor TERT

Pathways & Interactionsfor TERT

Drugs & Compoundsfor TERT

Transcriptsfor TERT

Expression for TERT

Orthologsfor TERT

Paralogsfor TERT

SNPs/Variantsfor TERT

Disorders & Mutationsfor TERT

Medical Newsfor TERT

Publicationsfor TERT

Search for TERT

Genome Databases showing TERT

Other Databases showing TERT

Specialized Databases showing TERT

Licensable Technologiesfor TERT

Servicesfor TERT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TERT

Summaries
for TERT

Genomic Location
for TERT

Proteins
for TERT

Protein Domains/
Families
for TERT

Gene Function
for TERT

Pathways & Interactions
for TERT

Drugs & Compounds
for TERT

Transcripts
for TERT

Expression
for TERT

Orthologs
for TERT

Paralogs
for TERT

SNPs/Variants
for TERT

Disorders & Mutations
for TERT

Medical News
for TERT

Publications
for TERT

Licensable Technologies
for TERT

Services
for TERT