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TERF2IP Gene

protein-coding GIFtS: 60

GC16P074239

telomeric repeat binding factor 2, interacting protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DRIP5 ^²
RAP1 ^¹, ², ³, ⁵
hRap1 ^³

Descriptions
TRF2-interacting telomeric RAP1 protein ^²
TRF2-interacting telomeric protein Rap1 ^³
dopamine receptor interacting protein 5 ^²
telomeric repeat binding factor 2, interacting protein ^²

External Ids
HGNC: 19246¹
Entrez Gene: 54386²
UniProtKB: Q9NYB0³
Ensembl: ENSG00000166848⁷

Search outside databases for aliases for TERF2IP gene

Previous GC identifers: GC16P066611 GC16P076642 GC16P075420 GC16P075461

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TE2IP_HUMAN, Q9NYB0

Function: May play a role in telomere length regulation. Component of the shelterin complex

(telosome) that is involved in the regulation of telomere length and protection. Shelterin

associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects

chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA

damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways

Gene Wiki entry for TERF2IP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TERF2IP gene

Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.3

TERF2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P074239: (about GC identifiers)

Start:	74,239,185 bp from pter
End:	74,248,829 bp from pter
Size:	9,645 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TE2IP_HUMAN, Q9NYB0 (See protein sequence)

Recommended Name: Telomeric repeat-binding factor 2-interacting protein 1

Size: 399 amino acids; 44260 Da

Subunit: Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2,

TERF2IP ACD and POT1. Binds to TRF2 (but not TRF1) with its C-terminus

Subcellular location: Nucleus. Telomere. Note=Colocalizes with telomeric DNA in interphase and

metaphase cells

Miscellaneous: Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself

Sequence caution: Sequence=AAL55783.1; Type=Frameshift; Positions=151; Sequence=BAA91317.1;

Type=Erroneous termination; Positions=299; Note=Translated as Glu;

PDB structures from and Proteopedia :

1FEX (3D)

Secondary accessions: Q8WYZ3 Q9NWR2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_061848.2

ENSEMBL proteins:

ENSP00000300086

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant TERF2IP Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAP1)
	Human Recombinant Proteins from Abnova (TERF2IP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	TAS	10850490
GO:0000783	nuclear telomere cap complex	IDA	15181449 16880378
GO:0005634	nucleus	IDA	17055345
GO:0005654	nucleoplasm	EXP	16166375
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for TERF2IP:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TERF2IP
	Sigma-Aldrich Antibody Arrays and Antibodies for TERF2IP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RAP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TERF2IP)
	Novus Biologicals Antibodies for TERF2IP

Assays for TERF2IP:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of TERF2IP
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NYB0

ProtoNet protein and cluster: Q9NYB0

1 Blocks protein family: IPB001357 BRCT domain

UniProtKB/Swiss-Prot: TE2IP_HUMAN, Q9NYB0

Similarity: Contains 1 BRCT domain

Similarity: Contains 1 Myb-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TERF2IP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TERF2IP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018975

Applied Biosystems Silencer® siRNAs for TERF2IP

Sigma-Aldrich siRNA for TERF2IP

Sigma-Aldrich shRNA for TERF2IP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TERF2IP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018975
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018975
untagged cDNA clone in CMV expression vector: NM_018975

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018975

UniProtKB/Swiss-Prot: TE2IP_HUMAN, Q9NYB0

Function: May play a role in telomere length regulation. Component of the shelterin complex

(telosome) that is involved in the regulation of telomere length and protection. Shelterin

associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects

chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA

damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	14690602
GO:0042162	NOT telomeric DNA binding	TAS	10850490

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TERF2IP

5/19 Interacting proteins for TERF2IP (Q9NYB0^{1, 2} ENSP00000300086³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TINF2	Q9BSI4-3¹, ENSP00000267415³	EBI-750109, EBI-717418 STRING (score=.999)
AP2B1	P63010²	MINT-67704
ORC2L	Q13416²	MINT-2831429
TERF2	ENSP00000254942³	STRING (score=.999)
POT1	ENSP00000350249³	STRING (score=.997)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007004	telomere maintenance via telomerase	TAS	10850490
GO:0031848	protection from non-homologous end joining at telomere	IMP	17499040
GO:0032205	negative regulation of telomere maintenance	IDA	17055345
GO:0045449	regulation of transcription	IEA	--
GO:0070198	protein localization to telomere	IMP	17499040

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TERF2IP
1 Novoseek chemical compound relationship for TERF2IP gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	97.88	17	12530079 (2), 15383534 (2), 16166375 (2), 15316005 (1) (see all 13)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TERF2IP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TERF2IP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018975

Sigma-Aldrich siRNA for TERF2IP

Sigma-Aldrich shRNA for TERF2IP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018975

REFSEQ mRNAs for TERF2IP gene:

NM_018975.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018975

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018975
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018975
                                 untagged cDNA clone in CMV expression vector: NM_018975

Additional cDNA sequence:

AF250393.1 AF262988.1 AF289599.1 AK298535.1 AK298880.1 AK307901.1 BC004465.1 BC005841.2

BC016739.1 BC022428.1 BC078171.1 CR600658.1 CR601111.1 CR605991.1 CR612877.1 CR613478.1

CR626430.1

24/26 DOTS entries (see all 26 ):

DT.119914 DT.100764395 DT.455827 DT.100654768 DT.100887098 DT.100699573 DT.100887099 DT.92449074

DT.99975006 DT.120666393 DT.120666414 DT.120666466 DT.95264203 DT.100662279 DT.100676787 DT.100836385

DT.100887097 DT.100887112 DT.120666356 DT.91683860 DT.95286125 DT.97859746 DT.100887108 DT.120666395

24/467 AceView cDNA sequences (see all 467 ):

AA617859 AA931557 BU734959 BC078171 AA434343 BQ424429 AV709151 BE695788

BG529655 AW292103 BI334411 BQ017033 BU682518 T16111 BQ222570 W19779

BC004465 AA447396 AI445177 BU687403 AW248587 BF149399 CR613478 AA382948

highest scoring ESTs for TERF2IP:

AA010763 AA011124 AA056043 AA113346 AA142859 AA164794 AA164795 AA164961 AA307828 AA310059

Unigene Cluster for TERF2IP:

Telomeric repeat binding factor 2, interacting protein

Hs.301419 [show with all ESTs]

Unigene Representative Sequence: AF289599

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TERF2IP

ExUns:	1a	·	1b	·	1c	^	2	^	3
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for TERF2IP

1 Ensembl transcript including schematic representation:

ENST00000300086

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TERF2IP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TERF2IP

¹ / ² / ³

4 probe-sets matching TERF2IP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78205_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.01	AI929142	0.80	1.00	0.91	1
38982_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.99	W28865	0.80	1.00	0.91	1
201174_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018975	0.60	1.00	0.82	1
201174_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAGGTGAGG

SOURCE GeneReport for Unigene cluster: Hs.301419
Expression variation in blood from EXPOLDB for TERF2IP
UniProtKB/Swiss-Prot: TE2IP_HUMAN, Q9NYB0
Tissue specificity: Ubiquitous. Highly expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TERF2IP gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TERF2IP¹	--	telomeric repeat binding factor 2, interacting protein	91.92(n) 93.69(a)	479643 XM_536776.2 XP_536776.2
cow (Bos taurus)	TERF2IP¹	--	telomeric repeat binding factor 2, interacting protein	90.34(n) 90.93(a)	509625 NM_001075412.1 NP_001068880.1
rat (Rattus norvegicus)	Terf2ip¹	--	telomeric repeat binding factor 2, interacting protein	86.17(n) 86.26(a)	307861 NM_001013143.1 NP_001013161.1
mouse (Mus musculus)	Terf2ip^{1, 5}	8⁵	telomeric repeat binding factor 2, interacting protein^{1, 5}	86.52(n)¹ 86.17(a)¹	57321¹ NM_020584.1¹ NP_065609.1¹ AB041557⁵ AB041559⁵ (see all 22)
chicken (Gallus gallus)	TERF2IP¹	--	telomeric repeat binding factor 2, interacting protein	58.91(n) 48.74(a)	395122 NM_204468.1 NP_989799.1

About this table Species with no ortholog for TERF2IP

ENSEMBL Gene Tree for TERF2IP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in TERF2IP are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4888444^1,2	C,F,H	74247780(+)	`TGGAGA/GAGTTT`	1	K/E	mis¹		8		EU EA WA	840
	rs11639771^1,2	C,F,H	74249153(+)	`ACTATC/TAGGAA`	1	--	ng3¹		11		EU EA WA NA	982
	rs11556641^1,2	C,F,H	74248478(-)	`ATAATC/ACGTGT`	1	--	ut3¹ ese³		7		NA EU EA WA	558
	rs10308^1,2	C	74248610(-)	`ACTGAG/TAAGGG`	1	--	ut3¹ ese³		1		MN	184
--	rs7195089^1,2	C,F,H	74244562(+)	`aatgtA/Gtcaat`	1	--	int¹		4		EU EA WA	358
	rs7193066^1,2	C,F,H	74247022(+)	`TCTCAA/CACATG`	1	--	int¹		16		EU EA WA NA	1468
	rs7186790^1,2	F,H	74243647(+)	`TACTAG/TCACAC`	1	--	int¹		4		EU EA WA	416
--	rs4888443^1,2	A,C	74243012(+)	`gaaccA/Ggggag`	1	--	int¹		0	--	--	--	--
	rs17764821^1,2	F,H	74243247(+)	`CAAAAT/CAGAAC`	1	--	int¹		7		NA EU EA WA	538
--	rs16941865^1,2	F	74245470(+)	`GAAGCA/GAGCAT`	1	--	int¹		3		NA	142

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HapMap Linkage Disequilibrium images for TERF2IP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605061

2 Novoseek disease relationships for TERF2IP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	8.25	2	12530079 (1), 15181449 (1)
tumors	0.00	5	17020976 (3), 9380414 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

36/74 PubMed articles for TERF2IP gene (see all 74 ):

Identification of human RAP1: implications for telomere evolution. (PubMed id 10850490)^{1, 2, 3, 4} Li B.... de Lange T. (2000)
NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. (PubMed id 11545594)^{1, 3, 4} Hanaoka S....Nishimura Y. (2001)
Shelterin: the protein complex that shapes and safeguards human telomeres. (PubMed id 16166375)^{1, 3, 4} de Lange T. (2005)
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. (PubMed id 15383534)^{1, 3, 4} Liu D....Songyang Z. (2004)
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. (PubMed id 15316005)^{1, 3, 4} Ye J.Z....de Lange T. (2004)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Rap1 affects the length and heterogeneity of human telomeres. (PubMed id 14565979)^{1, 3} Li B. and de Lange T. (2003)
The human Rap1 protein complex and modulation of telomere length. (PubMed id 15100233)^{1, 3} O'Connor M.S....Songyang Z. (2004)
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. (PubMed id 17499040)^{1, 3} Bae N.S. and Baumann P. (2007)
The cAMP/Epac1/Rap1 pathway in pancreatic carcinoma. (PubMed id 18580452)³ Lorenz R....Weber C.K. (2008)
Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine. (PubMed id 18922916)³ Till K.J....Cawley J.C. (2008)
Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. (PubMed id 15838871)³ Antoine K.... Goubin G. (2005)
Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach. (PubMed id 7654184)¹ Magnier C....Enouf J. (1995)
Telomere binding of the Rap1 protein is required for meiosis in fission yeast. (PubMed id 11676924)¹ Chikashige Y. and Hiraoka Y. (2001)
Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. (PubMed id 1881914)¹ Sussel L. and Shore D. (1991)
Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP. (PubMed id 14581536)¹ Deng Z....Lieberman P.M. (2003)
Alterations in the rap1 signaling pathway are common in human gliomas. (PubMed id 9380414)¹ Gutmann D.H....Guha A. (1997)
Rap1 is involved in the signal transduction of myelin-associated glycoprotein. (PubMed id 18049479)¹ Taniguchi J....Yamashita T. (2008)
Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas. (PubMed id 12007281)¹ Matsutani N....Yasui W. (2001)
Rap1p is a negative regulator of the RAP1 gene. (PubMed id 8660466)¹ Graham I.R. and Chambers A. (1996)
MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases. (PubMed id 12082090)¹ Klinger M....Sexl V. (2002)
Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. (PubMed id 16096639)¹ Miller K.M....Cooper J.P. (2005)
Analysis of the RAP1 protein binding to homogeneous telomeric repeats in Saccharomyces castellii. (PubMed id 11816032)¹ Wahlin J. and Cohn M. (2002)
Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1. (PubMed id 14576067)¹ Prevost N....Brass L.F. (2004)
The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. (PubMed id 14659874)¹ Tan M....Price C.M. (2003)
Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. (PubMed id 12198116)¹ Meng J. and Casey P.J. (2002)
spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. (PubMed id 11676925)¹ Kanoh J. and Ishikawa F. (2001)
Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. (PubMed id 19218462)¹ McAvoy T....Nairn A.C. (2009)
A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1. (PubMed id 18188096)¹ Shimonkevitz R....Bar-Or D. (2008)
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. (PubMed id 17237767)¹ Xin H....Songyang Z. (2007)
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms. (PubMed id 12660175)¹ Brevet V....Gilson E. (2003)
Clinicopathological and prognostic relevance of Rap1-GAP expression in melanocytic tumors. (PubMed id 9373716)¹ Weiss J....Jung E.G. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54386	HGNC: 19246	AceView: TERF2IP	Ensembl:ENSG00000166848	euGenes: HUgn54386
ECgene: TERF2IP	H-InvDB: TERF2IP

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TERF2IP	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TERF2IP
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TERF2IP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TERF2IP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TERF2IP		Antibodies for TERF2IP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TERF2IP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TERF2IP)
	Antibodies (TERF2IP)
	Chimera RNAi (TERF2IP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (RAP1)
	Antibodies (RAP1)

Search OriGene for TERF2IP

Search Tocris compounds for TERF2IP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TERF2IP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TERF2IP Gene at Home site.
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TERF2IP Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for TERF2IP

Summaries
for TERF2IP

Genomic Location
for TERF2IP

Proteins
for TERF2IP

Protein Domains/
Families
for TERF2IP

Gene Function
for TERF2IP

Pathways & Interactions
for TERF2IP

Drugs & Compounds
for TERF2IP

Transcripts
for TERF2IP

Expression
for TERF2IP

Orthologs
for TERF2IP

Paralogs
for TERF2IP

SNPs/Variants
for TERF2IP

Disorders & Mutations
for TERF2IP

Medical News
for TERF2IP

Publications
for TERF2IP

Search for TERF2IP

Genome Databases showing TERF2IP

Other Databases showing TERF2IP

Specialized Databases showing TERF2IP

Licensable Technologies
for TERF2IP

Services
for TERF2IP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TERF2IP Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor TERF2IP

Summariesfor TERF2IP

Genomic Locationfor TERF2IP

Proteinsfor TERF2IP

Protein Domains/Familiesfor TERF2IP

Gene Functionfor TERF2IP

Pathways & Interactionsfor TERF2IP

Drugs & Compoundsfor TERF2IP

Transcriptsfor TERF2IP

Expression for TERF2IP

Orthologsfor TERF2IP

Paralogsfor TERF2IP

SNPs/Variantsfor TERF2IP

Disorders & Mutationsfor TERF2IP

Medical Newsfor TERF2IP

Publicationsfor TERF2IP

Search for TERF2IP

Genome Databases showing TERF2IP

Other Databases showing TERF2IP

Specialized Databases showing TERF2IP

Licensable Technologiesfor TERF2IP

Servicesfor TERF2IP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TERF2IP

Summaries
for TERF2IP

Genomic Location
for TERF2IP

Proteins
for TERF2IP

Protein Domains/
Families
for TERF2IP

Gene Function
for TERF2IP

Pathways & Interactions
for TERF2IP

Drugs & Compounds
for TERF2IP

Transcripts
for TERF2IP

Expression
for TERF2IP

Orthologs
for TERF2IP

Paralogs
for TERF2IP

SNPs/Variants
for TERF2IP

Disorders & Mutations
for TERF2IP

Medical News
for TERF2IP

Publications
for TERF2IP

Licensable Technologies
for TERF2IP

Services
for TERF2IP