Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TERF2 Gene

protein-coding   GIFtS: 63
GCID: GC16M069389

Telomeric Repeat Binding Factor 2


(Previous symbol: TRBF2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Telomeric Repeat Binding Factor 21 2     TTAGGG Repeat-Binding Factor 22 3
TRBF21 2 3     Telomeric Repeat Binding Protein 22
TRF22 3 5     Telomeric Repeat-Binding Factor 22
Telomeric DNA-Binding Protein2 3     

External Ids:    HGNC: 117291   Entrez Gene: 70142   Ensembl: ENSG000001326047   OMIM: 6020275   UniProtKB: Q155543   

Export aliases for TERF2 gene to outside databases

Previous GC identifers: GC16M060074 GC16M069767 GC16M069124 GC16M069165 GC16M067947 GC16M055267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TERF2 Gene:
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex.
This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere
length and plays a key role in the protective activity of telomeres. While having similar telomere binding
activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TERF2 Gene:
TERF2 (telomeric repeat binding factor 2) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and protein homodimerization activity. An important paralog of this gene is TERF1.

UniProtKB/Swiss-Prot: TERF2_HUMAN, Q15554
Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance
and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required
to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex,
TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation
of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added
by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from
the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together
with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded
overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and
repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of
DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to
control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork
passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to
repressing homology-directed repair (HDR), which can affect telomere length

Gene Wiki entry for TERF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TERF2 gene promoter:
         AML1a   GATA-1   Meis-1b   GATA-2   FOXC1   HOXA5   SEF-1 (1)   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTERF2 promoter sequence
   Search Chromatin IP Primers for TERF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TERF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

TERF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TERF2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069389:  view genomic region     (about GC identifiers)

Start:
69,389,464 bp from pter      End:
69,442,474 bp from pter
Size:
53,011 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TERF2_HUMAN, Q15554 (See protein sequence)
Recommended Name: Telomeric repeat-binding factor 2  
Size: 500 amino acids; 55551 Da
Subunit: Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1,
ACD and POT1. Interacts with TERF2IP. Interacts with NBN. Interacts with SLX4/BTBD12. Interacts with
DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct
Selected PDB 3D structures from and Proteopedia for TERF2 (see all 10):
1H6P (3D)        1VF9 (3D)        1VFC (3D)        1W0U (3D)        1XG1 (3D)        3BU8 (3D)    
Alternative splicing: 3 isoforms:  Q15554-1   Q15554-2   Q15554-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TERF2: NX_Q15554

Explore proteomics data for TERF2 at MOPED

Post-translational modifications: 

  • Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and
    rapidly localizes to damage sites1
  • Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control
    association with telomeres1
  • Ubiquitination2 at Lys293
  • Modification sites at PhosphoSitePlus

  • See TERF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005643.2  
    ENSEMBL proteins: 
     ENSP00000254942   ENSP00000463079   ENSP00000475507   ENSP00000456022   ENSP00000462726  
     ENSP00000457094   ENSP00000462523   ENSP00000454955   ENSP00000456062   ENSP00000476905  
     ENSP00000474453  
    Reactome Protein details: Q15554

    TERF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TERF2
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for TERF2
    OriGene Custom Protein Services for TERF2
    GenScript Custom Purified and Recombinant Proteins Services for TERF2
    Novus Biologicals TERF2 Protein
    Novus Biologicals TERF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TERF2

     
    Search eBioscience for Proteins for TERF2 

    TERF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TERF2
    R&D Systems Antibodies for TERF2 (TRF-2)
    Cell Signaling Technology (CST) Antibodies for TERF2  (TRF2)
    OriGene Antibodies for TERF2
    OriGene Custom Antibody Services for TERF2
    Novus Biologicals TERF2 Antibodies
    Abcam antibodies for TERF2
    Cloud-Clone Corp. Antibodies for TERF2
    ThermoFisher Antibodies for TERF2
    LSBio Antibodies in human, mouse, rat for TERF2

    TERF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TERF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TERF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TERF2
    Cloud-Clone Corp. CLIAs for TERF2
    Search eBioscience for ELISAs for TERF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR017357 Telomere_repeat-bd-1/2
     IPR013867 Telomere_rpt-bd_fac_dimer_dom
     IPR001005 SANT/Myb
     IPR009057 Homeodomain-like
     IPR017930 Myb_dom

    Graphical View of Domain Structure for InterPro Entry Q15554

    ProtoNet protein and cluster: Q15554

    1 Blocks protein domain: IPB013867 Telomere repeat binding factor

    UniProtKB/Swiss-Prot: TERF2_HUMAN, Q15554
    Domain: The TRFH dimerization region mediates the interaction with DCLRE1B/Apollo but not TINF2
    Domain: The HTH domain is an independent structural unit and mediates binding to telomeric DNA
    Similarity: Contains 1 HTH myb-type DNA-binding domain


    Find genes that share domains with TERF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TERF2_HUMAN, Q15554
    Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance
    and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required
    to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex,
    TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation
    of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added
    by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from
    the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together
    with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded
    overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and
    repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of
    DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to
    control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork
    passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to
    repressing homology-directed repair (HDR), which can affect telomere length

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003691double-stranded telomeric DNA binding ISS9326950
    GO:0005515protein binding IPI10984620
    GO:0008022protein C-terminus binding IPI12181313
         
    Find genes that share ontologies with TERF2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Terf2):
     cellular  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with TERF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Terf2tm1.1Tdl for TERF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TERF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TERF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TERF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TERF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TERF2:
    hsa-mir-92a-3p (MIRT049699), hsa-mir-96-5p (MIRT048736), hsa-mir-15b-5p (MIRT046463), hsa-mir-766-3p (MIRT039036), hsa-mir-26b-5p (MIRT030265), hsa-mir-124-3p (MIRT023208)

    Block miRNA regulation of human, mouse, rat TERF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TERF2 (see all 17):
    hsa-miR-548v hsa-miR-221 hsa-miR-29b-1* hsa-miR-570 hsa-miR-214* hsa-miR-3154 hsa-miR-497* hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidTERF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TERF2
    Predesigned siRNA for gene silencing in human, mouse, rat TERF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TERF2

    Clone
    Products:
         
    OriGene clones in human, mouse for TERF2 (see all 8)
    OriGene ORF clones in mouse, rat for TERF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TERF2 (NM_005652)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TERF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TERF2
    Addgene plasmids for TERF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TERF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TERF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TERF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TERF2_HUMAN, Q15554: Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase cells and
    is located at chromosome ends during metaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA12768206
    GO:0000783nuclear telomere cap complex IDA15181449
    GO:0000784nuclear chromosome, telomeric region ----
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus IDA--

    Find genes that share ontologies with TERF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TERF2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Telomere Maintenance0.64
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    DNA Damage/Telomere Stress Induced Senescence0.65
    2Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    4Cell Cycle, Mitotic
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74


    Find genes that share SuperPaths with TERF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TERF2
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    2 Cell Signaling Technology (CST) Pathways for TERF2
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 BioSystems Pathway for TERF2
        Regulation of Telomerase

    3 Reactome Pathways for TERF2
        Packaging Of Telomere Ends
    Meiotic synapsis
    DNA Damage/Telomere Stress Induced Senescence


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TERF2: 
              Telomeres & Telomerase in human mouse rat
              Cellular Senescence in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TERF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TERF2 (Q155541, 2, 3 ENSP000002549424) via UniProtKB, MINT, STRING, and/or I2D (see all 283)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC2Q134161, 2, 3, ENSP000002342964EBI-706637,EBI-374957 MINT-2831336 MINT-2831672 MINT-2831554 I2D: score=2 STRING: ENSP00000234296
    ORC1Q134151, 2, 3, ENSP000003606214EBI-706637,EBI-374847 MINT-2831781 MINT-2831892 I2D: score=2 STRING: ENSP00000360621
    TOP3AQ134722, 3, ENSP000003216364MINT-6743829 MINT-6744175 MINT-6744122 MINT-6743896 MINT-6744078 I2D: score=1 STRING: ENSP00000321636
    H2AFXP161042, 3, ENSP000003643104MINT-8202883 MINT-8303424 I2D: score=1 STRING: ENSP00000364310
    BLMP541321, 3, ENSP000003472324EBI-706637,EBI-621372 I2D: score=5 STRING: ENSP00000347232
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0001309age-dependent telomere shortening NAS17395247
    GO:0001701in utero embryonic development IEA--
    GO:0007004telomere maintenance via telomerase IC15657433
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with TERF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TERF2

    7 Novoseek inferred chemical compound relationships for TERF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 97.7 65 15316005 (5), 15292264 (5), 12530079 (4), 15383534 (4) (see all 26)
    telomestatin 68.9 6 16302000 (3), 17409236 (2)
    arsenite 31.7 5 15904916 (3), 17643074 (1), 16129045 (1)
    adpribose 17.2 1 11494028 (1)
    oligonucleotide 11 4 19139067 (2)
    oxygen 2.44 1 15904916 (1)
    retinoic acid 0 1 14741354 (1)



    Find genes that share compounds with TERF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TERF2 gene: 
    NM_005652.4  

    Unigene Cluster for TERF2:

    Telomeric repeat binding factor 2
    Hs.63335  [show with all ESTs]
    Unigene Representative Sequence: NM_005652
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254942(uc002exd.3) ENST00000566051 ENST00000567130 ENST00000569584
    ENST00000566750 ENST00000569542 ENST00000566257 ENST00000564982 ENST00000569611
    ENST00000567296(uc002exe.3) ENST00000569280 ENST00000567841 ENST00000603068

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TERF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TERF2 (see all 17):
    hsa-miR-548v hsa-miR-221 hsa-miR-29b-1* hsa-miR-570 hsa-miR-214* hsa-miR-3154 hsa-miR-497* hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidTERF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TERF2
    Predesigned siRNA for gene silencing in human, mouse, rat TERF2
    Clone
    Products:
         
    OriGene clones in human, mouse for TERF2 (see all 8)
    OriGene ORF clones in mouse, rat for TERF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TERF2 (NM_005652)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TERF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TERF2
    Addgene plasmids for TERF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TERF2
    OriGene qSTAR qPCR primer pairs in human, mouse for TERF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TERF2
      QuantiTect SYBR Green Assays in human, mouse, rat TERF2
      QuantiFast Probe-based Assays in human, mouse, rat TERF2

    Additional mRNA sequence: 

    AF002999.1 BC024890.1 U95970.1 X93512.1 

    12 DOTS entries:

    DT.305481  DT.65287728  DT.95159827  DT.414733  DT.120681268  DT.92007747  DT.95159831  DT.97854670 
    DT.120681281  DT.92429428  DT.100811930  DT.95284783 

    Selected AceView cDNA sequences (see all 170):

    AW204639 CA424128 BE786175 BU751974 BM725371 BM475660 CB114373 BM725435 
    CB147579 CA445383 AA456985 NM_005652 AI350271 BE409049 BM999823 AI343840 
    BQ064661 BM460697 AA384904 BX090758 AI278205 F18285 AI366853 AA897198 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TERF2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                                -                       -                     
    SP2:                                                                              
    SP3:                                -                                             


    ECgene alternative splicing isoforms for TERF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TERF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTGAACC
    TERF2 Expression
    About this image


    TERF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H1 (WA01)
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TERF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TERF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.63335

    UniProtKB/Swiss-Prot: TERF2_HUMAN, Q15554
    Tissue specificity: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine,
    colon and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TERF2: 
              Telomeres & Telomerase in human mouse rat
              Cellular Senescence in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TERF2
    OriGene qSTAR qPCR primer pairs in human, mouse for TERF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TERF2
    QuantiTect SYBR Green Assays in human, mouse, rat TERF2
    QuantiFast Probe-based Assays in human, mouse, rat TERF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TERF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TERF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Terf21 , 5 telomeric repeat binding factor 21, 5 87.66(n)1
    85.5(a)1
      8 (53.59 cM)5
    217501  NM_009353.21  NP_033379.21 
     1070694005 
    chicken
    (Gallus gallus)
    Aves TERF21 telomeric repeat binding factor 2 64.4(n)
    54.99(a)
      395598  NM_001271892.1  NP_001258821.1 
    lizard
    (Anolis carolinensis)
    Reptilia TERF26
    telomeric repeat binding factor 2
    25(a)
    1 ↔ 1
    GL343643.1(55815-67414)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia terf21 telomeric repeat binding factor 2 53.24(n)
    44.84(a)
      100233217  NM_001143926.1  NP_001137398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii terfa1 telomeric repeat binding factor a 47.11(n)
    36.44(a)
      192316  NM_173243.1  NP_775350.1 


    ENSEMBL Gene Tree for TERF2 (if available)
    TreeFam Gene Tree for TERF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TERF2 gene
    TERF12  
    1 SIMAP similar gene for TERF2 using alignment to 9 protein entries:     TERF2_HUMAN (see all proteins):
    TERF1

    Find genes that share paralogs with TERF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TERF2 (see all 609)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925684631,2
    C--69389046(+) CACCAC/TGCCCA 1 -- int10--------
    rs1448986371,2
    --69389053(+) CCCAGA/CTAATT 1 -- int10--------
    rs1490211011,2
    --69389096(+) TTGGCC/TGCGCT 1 -- int10--------
    rs1438306581,2
    C--69389230(+) CCTTGC/GCTTTC 1 -- int10--------
    rs1509930991,2
    C--69389404(+) GCAAA-/GTTT  
            
    GTTTA
    1 -- int10--------
    rs759788371,2
    C,F--69389618(+) AAGCAC/AAACAC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs115392871,2
    C--69389662(-) CGTGTC/TTTGCA 1 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1848524921,2
    C--69389738(+) TATTCA/CATCGG 1 -- ut310--------
    rs1399668481,2
    C--69389741(+) CAATC-/AGGATT 1 -- ut310--------
    rs775465241,2
    C,F--69389784(+) GGGAAT/CTGGGA 1 -- ut311Minor allele frequency- C:0.07EA 120

    HapMap Linkage Disequilibrium report for TERF2 (69389464 - 69442474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TERF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509629CNV Insertion20534489
    esv269474CNV Insertion20981092
    esv272592CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TERF2
    DNA2.0 Custom Variant and Variant Library Synthesis for TERF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602027    OMIM disorders: --


    Find genes that share disorders with TERF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TERF2 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    werner syndrome 64.6 2 14712220 (1), 15200954 (1)
    promyelocytic leukemia 53.8 1 11082050 (1)
    nijmegen breakage syndrome 44.1 1 10888888 (1)
    bloom syndrome 37.9 1 12181313 (1)
    ataxia telangiectasia 36.5 1 19398584 (1)
    cancer 35.6 34 16302000 (3), 15905204 (2), 17643074 (2), 16142233 (2) (see all 19)
    acute leukemia 17.1 6 11179492 (3), 11123427 (1), 11481865 (1)
    gastric cancer 14.5 18 19399616 (6), 12530079 (2), 16760674 (2), 12148588 (1) (see all 5)
    tumors 12.4 35 20046894 (3), 12943625 (2), 17822315 (2), 17020976 (2) (see all 14)
    burkitt lymphoma 8.84 1 15476325 (1)

    Genetic Association Database (GAD): TERF2
    Human Genome Epidemiology (HuGE) Navigator: TERF2 (16 documents)

    Export disorders for TERF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TERF2 gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with TERF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. (PubMed id 9326950)1, 2, 3, 9 Broccoli D.... de Lange T. (Nat. Genet. 1997)
    2. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. (PubMed id 15316005)1, 2, 9 Ye J.Z.-S.... de Lange T. (J. Biol. Chem. 2004)
    3. Arginine methylation regulates telomere length and stability. (PubMed id 19596784)1, 2, 9 Mitchell T.R.... Zhu X.D. (Mol. Cell. Biol. 2009)
    4. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. (PubMed id 10888888)1, 2, 9 Zhu X.-D.... de Lange T. (Nat. Genet. 2000)
    5. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. (PubMed id 15383534)1, 2, 9 Liu D.... Songyang Z. (J. Biol. Chem. 2004)
    6. DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. (PubMed id 16223874)1, 2, 9 Tanaka H.... Gilley D. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. TRF2 protects human telomeres from end-to-end fusions. (PubMed id 9476899)1, 2, 9 van Steensel B.... de Lange T. (Cell 1998)
    8. Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse. (PubMed id 10226653)1, 3, 9 Sakaguchi A.Y....Giambernardi T.A. (Somat. Cell Mol. Genet. 1998)
    9. How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures. (PubMed id 15608617)1, 2, 9 Court R.... Rhodes D. (EMBO Rep. 2005)
    10. The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. (PubMed id 16730175)1, 2, 9 Lenain C....Gilson E. (Curr. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7014 HGNC: 11729 AceView: TERF2 Ensembl:ENSG00000132604 euGenes: HUgn7014
    ECgene: TERF2 H-InvDB: TERF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TERF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TERF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TERF2 gene:
    Search GeneIP for patents involving TERF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TERF2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TERF2 (TRF-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TERF2   OriGene RNAi products in human, mouse, rat for TERF2  
     OriGene qPCR primer pairs and template standards for TERF2   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for TERF2   OriGene clones in human, mouse for TERF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TERF2   OriGene Purified Protein for TERF2  
     OriGene ORF clones in mouse, rat for TERF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TERF2   OriGene Custom Protein Services for TERF2  

     
     
     Block miRNA regulation of human, mouse, rat TERF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TERF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TERF2 Predesigned siRNA for gene silencing in human, mouse, rat TERF2
     QuantiFast Probe-based Assays in human, mouse, rat TERF2 QuantiTect SYBR Green Assays in human, mouse, rat TERF2
     PCR Arrays including human, mouse, rat TERF2 Search Chromatin IP Primers for TERF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TERF2  GeneGlobe Interaction Network for TERF2
     Regulatory tfbs in TERF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TERF2 GenScript cDNA clones with any tag delivered in your preferred vector for TERF2
     GenScript Custom Assay Services for TERF2 GenScript Custom overexpressing Cell Line Services for TERF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TERF2  (TRF2)

     Search Tocris compounds for TERF2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TERF2 antibodies
     TERF2 proteins
     TERF2 lysates
     Antibodies for TERF2
     See all of Abcam's Antibodies, Kits and Proteins for TERF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TERF2
     Antibodies for TERF2
     ELISAs for TERF2
     CLIAs for TERF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TERF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TERF2
     SwitchGear 3'UTR luciferase reporter plasmids for TERF2
     SwitchGear Promoter luciferase reporter plasmids for TERF2
     ThermoFisher Antibodies for TERF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TERF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TERF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TERF2
     LSBio Antibodies in human, mouse, rat for TERF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TERF2
      Search eBioscience for proteins for TERF2
      Search eBioscience for elisas for TERF2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TERF2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4