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Aliases &
Descriptions
for TERC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| SCARNA19 1, 2 | | TR 1, 2, 5 | | TRC3 1, 2, 5 | | hTR 1, 2 |
| | | Descriptions |
|---|
| telomerase RNA component 2 |
|
| |
Search outside databases for aliases for TERC genePrevious GC identifers: GC03U990074 GC03M170803 |
Summaries
for TERC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TERC:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the
telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase
activity, and an RNA component, encoded by this gene, that serves as a template for the telomere
repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in
postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of
telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest
that telomerase also participates in chromosomal repair, since de novo synthesis of telomere
repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant
dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided
by RefSeq]
Gene Wiki entry for TERC (Telomerase_RNA_component) |
Genomic Location
for TERC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the TERC gene 
Entrez Gene cytogenetic band: 3q26 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26.2TERC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M170965:
(about GC identifiers)
Start:
|
170,965,092 bp from pter |
End:
|
170,965,542 bp from pter |
Size:
|
451 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins
for TERC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
|
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for TERC:
Assays for TERC: | Protein
Domains/
Families
for TERC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- | Gene Function
for TERC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
 Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Browse Origene for untagged/tagged cDNA clones in CMV expression vector
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NR_001566
Genatlas biochemistry entry for TERC:telomerase RNA component,involved in telomere maintenance as template in telomeric DNA
synthesis,transcription up-regulated by endogeneous TERT,strongly expressed in embryonic tissues
(undifferentialed neuroepithelium,epithelium,mesenchymes) absent in differentiated tissues except
dividing cells (testis,lymphoid follicles,regenerative epithelia)15/23 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Terc) (see all 23
):
| Pathways & Interactions
for TERC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for TERC
-- |
Drugs & Compounds
for TERC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TERC
10/14  Novoseek chemical compound relationships for TERC gene (see all 14
)
About this table
|
Transcripts
for TERC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Browse Origene for untagged/tagged cDNA clones in CMV expression vector
Additional cDNA sequence: BC128029.1 1 DOTS entry: DT.70100349 6 AceView cDNA sequences:NR_001566 AW207347 AI825849 AW293800 AI380754 AW136367 1 RNAdb entry of non coding RNAs:
LIT2117
 highest scoring ESTs for TERC:AI825849 AI380754 AW136367 AW207347 AW293800 BC128029 Unigene Cluster for TERC: Telomerase RNA component Hs.436182 [show with all ESTs]Unigene Representative Sequence: BC128029
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000363312(ncrna:misc_RNA)
|
Expression
for TERC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TERC expression in normal and diseased human tissues
 Applied Biosystems TaqMan ® Gene Expression Assays for TERC
1 / 2 / 3 1 probe-set matching TERC gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.436182
|
Orthologs
for TERC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TERC gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Terc5 |
3 |
telomerase RNA component |
-- |
AK085092 |
About this table Species with no ortholog for TERC
ENSEMBL Gene Tree for TERC | Paralogs
for TERC(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for TERC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for TERC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602322 disorders: 127550 609135 10/93 Novoseek disease relationships for TERC gene (see all 93
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dyskeratosis congenita |
94.04 |
32 |
15886322 (2), 14630445 (2), 16470156 (1), 17206847 (1) (see all 26) |
| dyskeratosis congenita, autosomal dominant |
93.00 |
14 |
17206847 (1), 16284252 (1), 17392301 (1), 12676774 (1) (see all 11) |
| hoyeraal-hreidarsson syndrome |
79.42 |
1 |
12833411 (1) |
| anemia aplastic |
63.80 |
20 |
16825992 (3), 12676774 (2), 15319288 (2), 18710936 (1) (see all 12) |
| cancer |
60.70 |
107 |
18562689 (4), 11866885 (3), 15847061 (3), 11768258 (2) (see all 57) |
| tumors |
48.82 |
138 |
10091748 (4), 9094971 (4), 9329458 (3), 15043789 (3) (see all 63) |
| cervical dysplasia |
42.31 |
1 |
14507648 (1) |
| germ-line mutation |
38.75 |
4 |
18753630 (1), 17392301 (1), 17913752 (1) |
| carcinoma |
37.99 |
51 |
16133023 (7), 15043789 (5), 12487901 (5), 15481329 (2) (see all 20) |
| precancerous lesions |
36.55 |
3 |
10547577 (1), 10863406 (1), 11748453 (1) |
About this table
GeneTests: TERC
Familial Pulmonary Fibrosis
Human Gene Mutation Database: TERC
Genetic Association Database: TERC
Human Genome Epidemiology Navigator: TERC (13 documents)
|
Medical News
for TERC(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for TERC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/428 PubMed articles for TERC gene (see all 428
):- Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. (PubMed id 16319170)1, 2, 3 Jady B.E....Kiss T. (2006)
- Lack of mutations in the human telomerase RNA component (hTERC) gene in Fanconi's anemia. (PubMed id 15339688)1, 3, 6 Calado R.T....Zago M.A. (2004)
- The RNA component of human telomerase. (PubMed id 7544491)1, 2, 3 Feng J....Yu J. (1995)
- TERC is not a major gene in human neural tube defects. (PubMed id 15329831)3, 6 Benz L.P....George T.M. (2004)
- Association between aplastic anaemia and mutations in telomerase RNA. (PubMed id 12090986)3, 6 Vulliamy T....Mason P.J. (2002)
- The polymorphism of telomerase RNA component gene in patients with systemic sclerosis. (PubMed id 12174094)3, 6 Ohtsuka T....Yamazaki S. (2002)
- TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. (PubMed id 18931339)1, 3 Du H.Y....Bessler M. (2008)
- Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations. (PubMed id 17640862)1, 3 Marrone A....Dokal I. (2007)
- Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation. (PubMed id 15481329)1, 3 Nakamura A....Aoyagi Y. (2004)
- Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation. (PubMed id 15753647)1, 3 Cerone M.A....Autexier C. (2005)
|
Search for TERC
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TERC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TERC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TERC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for TERC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for TERC:
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