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Aliases for TERC Gene

Subcategory (RNA class) for TERC Gene

telomerase RNA

Quality Score for this RNA gene is

8

Aliases for TERC Gene

  • Telomerase RNA Component 2 3
  • Small Cajal Body-Specific RNA 19 2 3
  • PFBMFT2 3 6
  • DKCA1 3 6
  • TRC3 3 6
  • TR 3 6
  • SCARNA19 3
  • HTR 3

External Ids for TERC Gene

Summaries for TERC Gene

Entrez Gene Summary for TERC Gene

  • Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TERC Gene

TERC (Telomerase RNA Component) is a RNA Gene, and belongs to telomerase RNA RNA class. Diseases associated with TERC include cervical intraepithelial neoplasia and terc-related dyskeratosis congenita.

Gene Wiki entry for TERC Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TERC Gene

Genomics for TERC Gene

Genomic Location for TERC Gene

Start:
169,764,520 bp from pter
End:
169,765,060 bp from pter
Size:
541 bases
Orientation:
Minus strand

Genomic View for TERC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TERC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TERC Gene

Regulatory Elements for TERC Gene

ORGUL Member Location for TERC Gene

ORGUL Member Location for TERC gene

Proteins for TERC Gene

Post-translational modifications for TERC Gene

No Post-translational modifications

No data available for DME Specific Peptides for TERC Gene

Domains for TERC Gene

Gene Families for TERC Gene

HGNC:
  • MISCRNA :ncRNAs / Small misc ncRNAs
genes like me logo Genes that share domains with TERC: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for TERC Gene

Function for TERC Gene

Molecular function for TERC Gene

GENATLAS Biochemistry: telomerase RNA component,involved in telomere maintenance as template in telomeric DNA synthesis,transcription up-regulated by endogeneous TERT,strongly expressed in embryonic tissues (undifferentialed neuroepithelium,epithelium,mesenchymes) absent in differentiated tissues except dividing cells (testis,lymphoid follicles,regenerative epithelia)
genes like me logo Genes that share phenotypes with TERC: view

Animal Models for TERC Gene

MGI Knock Outs for TERC:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for TERC Gene

Localization for TERC Gene

No data available for Gene Ontology (GO) - Cellular Components for TERC Gene

Pathways for TERC Gene

SuperPathways for TERC Gene

No Data Available

Interacting Proteins for TERC Gene

Gene Ontology (GO) - Biological Process for TERC Gene

None

No data available for Pathways by source for TERC Gene

Compounds for TERC Gene

(32) Novoseek inferred chemical compound relationships for TERC Gene

Compound -log(P) Hits PubMed IDs
tin(2+) 73.8 6
pseudouridine 51.4 2
2,5-oligoadenylate 48.6 7
oligonucleotide 41.2 15
lipofectamine 30.1 1
genes like me logo Genes that share compounds with TERC: view

Transcripts for TERC Gene

mRNA/cDNA for TERC Gene

(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TERC Gene

Telomerase RNA component:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TERC Gene

No ASD Table

Relevant External Links for TERC Gene

GeneLoc Exon Structure for
TERC
ECgene alternative splicing isoforms for
TERC

Expression for TERC Gene

mRNA expression in normal human tissues for TERC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TERC Gene

This gene is overexpressed in Testis (4.1).

SOURCE GeneReport for Unigene cluster for TERC Gene Hs.436182

genes like me logo Genes that share expressions with TERC: view

Orthologs for TERC Gene

This gene was present in the common ancestor of chordates.

Orthologs for TERC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia Telomerase-vert 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia Telomerase-vert 37
  • 83 (a)
OneToMany
Telomerase-vert 37
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia Telomerase-vert 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm24413 37
  • 63 (a)
OneToMany
Terc 16
Terc 37
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia Telomerase-vert 37
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves Telomerase-vert 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia Telomerase-vert 37
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Telomerase-vert 37
  • 48 (a)
OneToOne
Species with no ortholog for TERC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TERC Gene

ENSEMBL:
Gene Tree for TERC (if available)
TreeFam:
Gene Tree for TERC (if available)

Paralogs for TERC Gene

No data available for Paralogs for TERC Gene

Variants for TERC Gene

Sequence variations from dbSNP and Humsavar for TERC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2293607 -- 169,764,547(-) CGGCA(A/G)TGGGG downstream-variant-500B
rs35073794 -- 169,764,347(-) CTCTG(C/T)AGATT downstream-variant-500B
rs35103076 -- 169,764,760(+) CTCTT(-/T)CGCGG nc-transcript-variant
rs35421373 -- 169,764,321(-) CTTCT(C/G)CCAAG downstream-variant-500B
rs58465486 -- 169,765,773(+) GATGG(-/G)AGTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TERC Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
esv2422204 CNV Deletion 17116639

Relevant External Links for TERC Gene

HapMap Linkage Disequilibrium report
TERC
Human Gene Mutation Database (HGMD)
TERC
Locus Specific Mutation Databases (LSDB)
TERC

Disorders for TERC Gene

(3) OMIM Diseases for TERC Gene (602322)

(94) Novoseek inferred disease relationships for TERC Gene

Disease -log(P) Hits PubMed IDs
dyskeratosis congenita 94.6 30
dyskeratosis congenita, autosomal dominant 92.6 11
hoyeraal-hreidarsson syndrome 77.5 1
anemia aplastic 65.9 16
cancer 60 81

Relevant External Links for TERC

GeneTests
TERC
GeneReviews
TERC
Genetic Association Database (GAD)
TERC
Human Genome Epidemiology (HuGE) Navigator
TERC
genes like me logo Genes that share disorders with TERC: view

No data available for UniProtKB/Swiss-Prot for TERC Gene

Publications for TERC Gene

  1. The RNA component of human telomerase. (PMID: 7544491) Feng J. … Yu J. (Science 1995) 2 3 23
  2. Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. (PMID: 16319170) JA!dy B.E. … Kiss T. (Mol. Biol. Cell 2006) 2 3 23
  3. Lack of mutations in the human telomerase RNA component (hTERC) gene in Fanconi's anemia. (PMID: 15339688) Calado R.T. … Zago M.A. (Haematologica 2004) 3 23 49
  4. Telomere shortening in familial and sporadic pulmonary fibrosis. (PMID: 18635888) Cronkhite J.T. … Garcia C.K. (Am. J. Respir. Crit. Care Med. 2008) 3 23 49
  5. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. (PMID: 18931339) Du H.Y. … Bessler M. (Blood 2009) 3 23 49

Products for TERC Gene

  • Copy Number PCR Panels: for TERC
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TERC
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TERC
    • Block miRNA regulation of TERC using miScript Target Protectors

    Sources for TERC Gene

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