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TEPP Gene

protein-coding   GIFtS: 41
GCID: GC16P058010

Testis, Prostate And Placenta Expressed

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis, Prostate And Placenta Expressed1 2
Testis, Prostate And Placenta-Expressed Protein2
Testis/Prostate/Placenta-Expressed Protein2

External Ids:    HGNC: 337451   Entrez Gene: 3747392   Ensembl: ENSG000001596487   OMIM: 6102645   UniProtKB: Q6URK83   

Export aliases for TEPP gene to outside databases

Previous GC identifers: GC16P057785 GC16P056567 GC16P043877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEPP Gene:
TEPP (testis, prostate and placenta expressed) is a protein-coding gene. Diseases associated with TEPP include prostatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEPP gene promoter:
         GATA-3   YY1   GATA-1   GATA-2   RORalpha1   SREBP-1a   FOXO4   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEPP promoter sequence
   Search Chromatin IP Primers for TEPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

TEPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEPP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058010:  view genomic region     (about GC identifiers)

Start:
58,010,339 bp from pter      End:
58,022,020 bp from pter
Size:
11,682 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TEPP_HUMAN, Q6URK8 (See protein sequence)
Recommended Name: Testis, prostate and placenta-expressed protein precursor  
Size: 271 amino acids; 30717 Da
Secondary accessions: Q6URK7
Alternative splicing: 2 isoforms:  Q6URK8-1   Q6URK8-2   

Explore the universe of human proteins at neXtProt for TEPP: NX_Q6URK8

Explore proteomics data for TEPP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_950247.2  NP_955535.2  

    ENSEMBL proteins: 
     ENSP00000290871   ENSP00000401917  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6URK8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for TEPP:
     Decreased viability of wild-ty  Proliferating cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTEPP 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEPP_HUMAN, Q6URK8: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    TEPP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEPP
    Interactions:

        Search GeneGlobe Interaction Network for TEPP

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEPP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEPP gene (2 alternative transcripts): 
    NM_199046.2  NM_199456.2  

    Unigene Cluster for TEPP:

    Testis, prostate and placenta expressed
    Hs.132976  [show with all ESTs]
    Unigene Representative Sequence: NM_199046
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290871(uc002emv.4) ENST00000441824(uc002emw.4) ENST00000569996
    ENST00000562915
    miRNA
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    hsa-miR-942 hsa-miR-185* hsa-miR-3151 hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidTEPP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AY363222.1 AY363223.1 BC104458.1 BC104459.1 

    4 DOTS entries:

    DT.405285  DT.40129532  DT.70102525  DT.92416901 

    16 AceView cDNA sequences:

    BX111631 NM_199456 NM_199046 BX647108 AI675324 AY363222 BX100493 BF447201 
    BE859006 AY363223 AI972582 AI028639 AA394194 BF980073 AA398110 AW183262 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TEPP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                      
    SP2:                                      -               
    SP3:              -                       -               


    ECgene alternative splicing isoforms for TEPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTTAAGC
    TEPP Expression
    About this image


    TEPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Testis (Reproductive System)
     
     Prostate (Endocrine System)
    TEPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEPP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132976

    UniProtKB/Swiss-Prot: TEPP_HUMAN, Q6URK8
    Tissue specificity: Expressed in testis, prostate and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEPP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TEPP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tepp1 , 5 testis, prostate and placenta expressed1, 5 81.79(n)1
    79.17(a)1
      8 (47.12 cM)5
    734071  NM_199455.21  NP_955534.11 
     953105665 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tepp1 testis, prostate and placenta expressed 52.79(n)
    45.41(a)
      100316910  NM_001170510.1  NP_001163981.1 


    ENSEMBL Gene Tree for TEPP (if available)
    TreeFam Gene Tree for TEPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEPP (see all 347)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493020631,2
    C--58008423(+) GTTTCA/GCCATG 2 -- us2k10--------
    rs778978821,2
    F--58008492(+) AAGGGC/TTGGAA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs772291761,2
    C,F--58008593(+) ATTCCC/TGTTGC 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs110762101,2
    C,F,A,H--58008617(+) ctcacG/Accaga 2 -- us2k115Minor allele frequency- A:0.19NS NA WA CSA EA 493
    rs110762111,2
    C,F,A,H--58008642(+) cattcG/Atacac 2 -- us2k128Minor allele frequency- A:0.50NS EA NA WA CSA 2765
    rs1152770791,2
    C,F--58008681(+) TTCTGC/TGTCTA 2 -- us2k11Minor allele frequency- T:0.10WA 118
    rs1861918991,2
    --58008729(+) CATACA/GATATG 2 -- us2k10--------
    rs1142218751,2
    C,F--58008762(+) TTGATG/ATAGCG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1137986821,2
    C--58008840(+) AGTATC/TGCATG 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs762344271,2
    C,F--58008855(+) AGACGC/AACCAC 2 -- us2k11Minor allele frequency- A:0.10WA 118

    HapMap Linkage Disequilibrium report for TEPP (58010339 - 58022020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TEPP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523659CNV Loss19592680
    dgv2875n71CNV Loss21882294
    nsv1816CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610264    OMIM disorders: --

    1 disease for TEPP:    
    About MalaCards
    prostatitis


    TEPP for disorders           About GeneDecksing


    Export disorders for TEPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEPP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. (PubMed id 14652002)1, 2, 3 Bera T.K.... Pastan I.H. (Biochem. Biophys. Res. Commun. 2003)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374739 HGNC: 33745 AceView: TEPP Ensembl:ENSG00000159648 euGenes: HUgn374739
    ECgene: TEPP H-InvDB: TEPP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEPP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEPP gene:
    Search GeneIP for patents involving TEPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     SwitchGear 3'UTR luciferase reporter plasmids for TEPP
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     Search ThermoFisher Antibodies for TEPP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEPP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEPP
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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