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Aliases for TEPP Gene

Aliases for TEPP Gene

  • Testis, Prostate And Placenta Expressed 2 3 5

External Ids for TEPP Gene

Previous GeneCards Identifiers for TEPP Gene

  • GC16P057785
  • GC16P056567
  • GC16P058010
  • GC16P043877

Summaries for TEPP Gene

GeneCards Summary for TEPP Gene

TEPP (Testis, Prostate And Placenta Expressed) is a Protein Coding gene.

Additional gene information for TEPP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEPP Gene

Genomics for TEPP Gene

Regulatory Elements for TEPP Gene

Enhancers for TEPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H057984 0.9 ENCODE 39.2 +8.9 8880 1 TBP HDGF ATF1 ZBTB40 EGR1 SCRT2 EGR2 SP3 SP5 ZBTB2 TEPP CFAP20 CNGB1 PIR35383 GC16M057997
GH16H057992 0.9 ENCODE 31.9 +18.0 17952 3 HDAC1 HDGF PKNOX1 RB1 ARID4B ZBTB40 RAD21 ATF7 CEBPB REST TEPP ZNF319 PIR35383 GC16M057997 CNGB1
GH16H057975 1 ENCODE 21.9 0.0 -45 0 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 FOS ATF7 NCOA1 REST TEPP GC16M057968
GH16H057998 1.1 ENCODE 19.8 +23.8 23779 4 HDGF ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 MXD4 REST TEPP ZNF319 USB1
GH16H058021 1.6 Ensembl ENCODE dbSUPER 13.3 +49.0 49025 7 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SP3 TEPP CNOT1 CFAP20 CNGB1 CSNK2A2 ZNF319 MMP15 GC16P058028
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEPP on UCSC Golden Path with GeneCards custom track

Genomic Location for TEPP Gene

Chromosome:
16
Start:
57,976,435 bp from pter
End:
57,988,354 bp from pter
Size:
11,920 bases
Orientation:
Plus strand

Genomic View for TEPP Gene

Genes around TEPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEPP Gene

Proteins for TEPP Gene

  • Protein details for TEPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6URK8-TEPP_HUMAN
    Recommended name:
    Testis, prostate and placenta-expressed protein
    Protein Accession:
    Q6URK8
    Secondary Accessions:
    • Q6URK7

    Protein attributes for TEPP Gene

    Size:
    271 amino acids
    Molecular mass:
    30717 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TEPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEPP Gene

Post-translational modifications for TEPP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEPP Gene

No data available for DME Specific Peptides for TEPP Gene

Domains & Families for TEPP Gene

Gene Families for TEPP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TEPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEPP: view

No data available for UniProtKB/Swiss-Prot for TEPP Gene

Function for TEPP Gene

Phenotypes From GWAS Catalog for TEPP Gene

Phenotypes for TEPP Gene

GenomeRNAi human phenotypes for TEPP:
genes like me logo Genes that share phenotypes with TEPP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEPP Gene

Localization for TEPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEPP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEPP gene
Compartment Confidence
extracellular 4
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TEPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TEPP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEPP Gene

Pathways & Interactions for TEPP Gene

No Data Available

Interacting Proteins for TEPP Gene

Gene Ontology (GO) - Biological Process for TEPP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEPP Gene

Drugs & Compounds for TEPP Gene

No Compound Related Data Available

Transcripts for TEPP Gene

mRNA/cDNA for TEPP Gene

Unigene Clusters for TEPP Gene

Testis, prostate and placenta expressed:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TEPP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -
SP3: - -

Relevant External Links for TEPP Gene

GeneLoc Exon Structure for
TEPP
ECgene alternative splicing isoforms for
TEPP

Expression for TEPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEPP Gene

This gene is overexpressed in Testis (x21.6) and Thyroid (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEPP Gene



Protein tissue co-expression partners for TEPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEPP Gene:

TEPP

SOURCE GeneReport for Unigene cluster for TEPP Gene:

Hs.132976

mRNA Expression by UniProt/SwissProt for TEPP Gene:

Q6URK8-TEPP_HUMAN
Tissue specificity: Expressed in testis, prostate and placenta.
genes like me logo Genes that share expression patterns with TEPP: view

Primer Products

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEPP Gene

Orthologs for TEPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEPP 33 34
  • 96.98 (n)
cow
(Bos Taurus)
Mammalia TEPP 33 34
  • 87.35 (n)
dog
(Canis familiaris)
Mammalia TEPP 33 34
  • 86.57 (n)
mouse
(Mus musculus)
Mammalia Tepp 33 16 34
  • 81.79 (n)
rat
(Rattus norvegicus)
Mammalia Tepp 33
  • 80.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TEPP 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEPP 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tepp 33
  • 52.79 (n)
Species where no ortholog for TEPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEPP Gene

ENSEMBL:
Gene Tree for TEPP (if available)
TreeFam:
Gene Tree for TEPP (if available)

Paralogs for TEPP Gene

No data available for Paralogs for TEPP Gene

Variants for TEPP Gene

Sequence variations from dbSNP and Humsavar for TEPP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000679874 -- 57,983,757(+) CAGTC(A/G)CGTGC intron-variant
rs1000710622 -- 57,983,643(+) GTCTC(A/G)CTCTG intron-variant
rs1001055620 -- 57,979,041(+) CCTCA(C/G)AGCCC intron-variant
rs1001097762 -- 57,977,465(+) AATAC(C/T)ACCTC intron-variant
rs1001311227 -- 57,977,097(+) TGCTG(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEPP Gene

Variant ID Type Subtype PubMed ID
nsv1063386 CNV gain 25217958
nsv1816 CNV deletion 18451855
nsv523659 CNV loss 19592680
nsv572759 CNV loss 21841781

Variation tolerance for TEPP Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEPP Gene

Disorders for TEPP Gene

Relevant External Links for TEPP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEPP

No disorders were found for TEPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEPP Gene

Publications for TEPP Gene

  1. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. (PMID: 14652002) Bera TK … Pastan IH (Biochemical and biophysical research communications 2003) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for TEPP Gene

Sources for TEPP Gene

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