V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TEP1 Gene

protein-coding GIFtS: 62

GC14M019903

telomerase-associated protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TLP1 ^¹, ², ³
TP1 ^¹, ², ³, ⁵
TROVE1 ^¹, ²
VAULT2 ^¹, ²
p240 ^¹, ², ³

Descriptions
TROVE domain family, member 1 ^²
Telomerase protein 1 ^³
p80 telomerase homolog ^², ³
telomerase protein component 1 ^²
telomerase-associated protein 1 ^², ³

External Ids
HGNC: 11726¹
Entrez Gene: 7011²
UniProtKB: Q99973³
Ensembl: ENSG00000129566⁷

Search outside databases for aliases for TEP1 gene

Previous GC identifers: GC14M018206 GC14M014623 GC14M018826

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TEP1:

This gene product is a component of the ribonucleoprotein complex responsible for telomerase

activity which catalyzes the addition of new telomeres on the chromosome ends. The

telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq]

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Function: Component of the telomerase ribonucleoprotein complex that is essential for the

replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a

multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing

and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to

TERC (By similarity)

Gene Wiki entry for TEP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TEP1 gene

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

TEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M019903: (about GC identifiers)

Start:	19,905,766 bp from pter
End:	19,951,420 bp from pter
Size:	45,655 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973 (See protein sequence)

Recommended Name: Telomerase protein component 1

Size: 2627 amino acids; 290490 Da

Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1,

WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).

Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more

vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity)

Subcellular location: Nucleus (Probable). Telomere

Secondary accessions: A0AUV9

Alternative splicing: 2 isoforms: Q99973-1 Q99973-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_009041.2

ENSEMBL proteins:

ENSP00000262715 ENSP00000352180

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TEP1)
	Human Recombinant Proteins from Abnova (TEP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000781	chromosome, telomeric region	IEA	--
GO:0005625	soluble fraction	ISS	--
GO:0005634	nucleus	IEA	--
GO:0005694	chromosome	IEA	--
GO:0005697	telomerase holoenzyme complex	IDA	12135483

About this table

Antibodies for TEP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TEP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TEP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TEP1)
	Novus Biologicals Antibodies for TEP1

Assays for TEP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99973

ProtoNet protein and cluster: Q99973

2 Blocks protein families:

IPB001680 G-protein beta WD-40 repeat signature

IPB008858 TROVE

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Similarity: Contains 1 NACHT domain

Similarity: Contains 4 TEP1 N-terminal repeats

Similarity: Contains 1 TROVE domain

Similarity: Contains 21 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TEP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TEP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007110

Applied Biosystems Silencer® siRNAs for TEP1

Sigma-Aldrich siRNA and siRNA Panels for TEP1

Sigma-Aldrich shRNA for TEP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007110
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007110
untagged cDNA clone in CMV expression vector: NM_007110

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007110

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Function: Component of the telomerase ribonucleoprotein complex that is essential for the

replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a

multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing

and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to

TERC (By similarity)

Genatlas biochemistry entry for TEP1:

telomerase protein component 1

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tep1):

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003720	contributes to telomerase activity	IDA	12135483
GO:0003723	RNA binding	ISS	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TEP1

5/8 Interacting proteins for TEP1 (ENSP00000262715³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TERT	ENSP00000309572³	STRING (score=.996)
PRKCA	ENSP00000284384³	STRING (score=.96)
ADAM29	ENSP00000352177³	STRING (score=.899)
IGHG4	ENSP00000374984³	STRING (score=.899)
TNKS	ENSP00000311579³	STRING (score=.899)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000722	telomere maintenance via recombination	IDA	10810353

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TEP1
1 Novoseek chemical compound relationship for TEP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	81.43	4	12007281 (2), 11494028 (1), 17616810 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TEP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TEP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007110

Sigma-Aldrich siRNA and siRNA Panels for TEP1

Sigma-Aldrich shRNA for TEP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007110

REFSEQ mRNAs for TEP1 gene:

NM_007110.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007110

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007110
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007110
                                 untagged cDNA clone in CMV expression vector: NM_007110

Additional cDNA sequence:

AB209669.1 AK124360.1 AK303307.1 BC126107.1 BC143812.1 BC143815.1 BX640983.1 U86136.2

9 DOTS entries:

DT.40117791 DT.99991901 DT.97845575 DT.86848766 DT.100659440 DT.92422291 DT.40192344 DT.92050248

DT.95245860

24/114 AceView cDNA sequences (see all 114 ):

BM555079 AI040596 BM676849 BQ021178 AK124360 BM555913 AI476293 CA422831

BM556823 BM556329 CK823973 BF197089 BM810250 AI867200 BQ304178 BU543910

BQ957505 AW054694 N58857 BE739840 NM_007110 AA722421 BU521152 CF147492

highest scoring ESTs for TEP1:

U86136 AI819204 AL703869 AW025109 AW752002 BE207462 BE739840 BE825654 BE933739 BE940121

Unigene Cluster for TEP1:

Telomerase-associated protein 1

Hs.508835 [show with all ESTs]

Unigene Representative Sequence: NM_007110

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TEP1 (see all 8 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39a	·	39b	^	40a	·	40b	^	41	^	42	^	43	^	44	^	45	^
SP1:
SP2:											-
SP3:
SP4:																																							-
SP5:

ExUns:	46	^	47	^	48	^	49a	·	49b	·	49c	^	50	^	51a	·	51b	^	52	^	53	^	54a	·	54b	·	54c	^	55a	·	55b	^	56a	·	56b	·	56c	^	57
SP1:
SP2:																													-
SP3:																							-												-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TEP1

2 Ensembl transcripts including schematic representations:

ENST00000262715 ENST00000359243

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TEP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TEP1

¹ / ² / ³

6 probe-sets matching TEP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90203_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.37	AI819204	0.60	1.00	0.82	1
1701_at²^{, 3}	U95-A	1	0.94	1.00	0.74	0.64	U86136	1.00	1.00	1.00	1
205727_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007110	0.60	1.00	0.82	1
228670_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BF197089	0.40	1.00	0.76	1
205727_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228670_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACTAGTGCC

SOURCE GeneReport for Unigene cluster: Hs.508835
Expression variation in blood from EXPOLDB for TEP1
UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TEP1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TEP1¹	--	telomerase-associated protein 1	78.21(n) 72.83(a)	482555 XM_539672.2 XP_539672.2
chimpanzee (Pan troglodytes)	TEP1¹	--	telomerase-associated protein 1	99.15(n) 98.48(a)	465198 XM_001137917.1 XP_001137917.1
cow (Bos taurus)	TEP1¹	--	telomerase-associated protein 1	84.74(n) 80.68(a)	505802 XM_582150.3 XP_582150.3
rat (Rattus norvegicus)	Tep1¹	--	telomerase associated protein 1	79.85(n) 75.36(a)	64523 NM_022591.1 NP_072113.1
mouse (Mus musculus)	Tep1⁵ Tep1¹	14 (13.50 cM)⁵	telomerase associated protein 1^{1, 5}	80.1(n)¹ 75.82(a)¹	21745¹ NM_009351.2¹ NP_033377.1¹ AB035264⁵ AF005885⁵ (see all 16)

About this table Species with no ortholog for TEP1

ENSEMBL Gene Tree for TEP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/314 NCBI SNPs in TEP1 are shown (see all 314 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 145)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs938886^1,2	A,C,F,H,O	19907541(+)	`CATAGC/GATCCC`	1	I/M	mis¹ ese³		26	NA EA MN EU WA	2032
	rs1760898^1,2	A,C,F,H,O	19942721(-)	`AATAAC/AATCTT`	1	K/N	mis¹ ese³		24	EA NA MN CSAM EU WA	3492
	rs1713456^1,2	A,C,F,H	19919933(+)	`CGAGGC/TAGGCA`	1	C/Y	mis¹ ese³		17	EA NA MN EU WA	1496
	rs4246977^1,2	A,C,F,H	19952431(+)	`tggtaT/Cttagg`	1	--	ng3¹		8	EU EA WA	836
	rs2228035^1,2	C,F,H,O	19941813(-)	`GGACAA/GATTTG`	1	K/R	mis¹ ese³		14	MN NA EA EU WA	1162
	rs1760903^1,2	A,C,F,H	19922657(-)	`CCGCAT/CGTCGG`	1	C/R	mis¹ ese³		12	MN EA EU WA NA	2630
	rs1760904^1,2	A,C,F,H	19921869(-)	`TGGCAC/TCATTA`	1	S/P	mis¹ ese³		16	MN EA CSAM NA EU WA	2784
	rs2104978^1,2	A,C,F,H	19906873(-)	`CCTCCA/GTGTGC`	1	H/R	mis¹ ese³		13	EU EA WA MN NA	1102
	rs1713449^1,2	C,F,H,O	19911547(+)	`CCCGAC/TGGTTA`	1	V/I	mis¹		21	MN EA CSAM NA EU WA	3246
	rs1760890^1,2	C,F,H,O	19951629(-)	`AAGGCT/GGCAGG`	1	--	ng3¹ tfbs³		7	EU EA WA NA	546

About this table

HapMap Linkage Disequilibrium images for TEP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601686

10/23 Novoseek disease relationships for TEP1 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
endometrial hyperplasia	34.85	1	11820598 (1)
cancer	34.30	9	9537264 (2), 14621192 (1), 9676833 (1), 10568811 (1) (see all 8)
tumors	33.62	6	11494028 (1), 9935231 (1), 12943625 (1), 12970299 (1) (see all 6)
gastric cancer	32.33	3	11343177 (1), 16696344 (1)
gastric carcinoma	31.99	3	11494028 (1), 12007281 (1), 9914776 (1)
carcinoma squamous cell	27.02	6	8425208 (1), 11167139 (1), 15112252 (1), 10568811 (1) (see all 5)
benign tumor	24.21	1	12440093 (1)
leukemia	22.93	3	9753073 (1), 15165114 (1), 11877056 (1)
glioblastoma	22.71	2	9874800 (1), 17196947 (1)
acute leukemia	20.34	1	11877056 (1)

About this table

Human Genome Epidemiology Navigator: TEP1 (45 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

13/121 PubMed articles for TEP1 gene (see all 121 ):

Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. (PubMed id 9403057)^{1, 2, 3} Saito T....Ishikawa F. (1997)
Vaults and telomerase share a common subunit, TEP1. (PubMed id 10551828)^{1, 3, 4} Kickhoefer V.A....Rome L.H. (1999)
A mammalian telomerase-associated protein. (PubMed id 9020079)^{1, 3, 4} Harrington L.... Robinson M.O. (1997)
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. (PubMed id 11029039)^{1, 3, 4} Beattie T.L.... Harrington L. (2000)
Human telomerase contains evolutionarily conserved catalytic and structural subunits. (PubMed id 9389643)^{3, 4} Harrington L.... Robinson M.O. (1997)
Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. (PubMed id 14606063)^{1, 3} Li C....Wu X.Y. (2003)
Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. (PubMed id 10810353)^{1, 3} Koyanagi Y....Watanabe N. (2000)
Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. (PubMed id 10597287)^{1, 3} Li H....Liu J.P. (1999)
Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. (PubMed id 18938767)^{1, 3} Sipos F....Tulassay Z. (2008)
Genetic variation in five genes important in telomere biology and risk for breast cancer. (PubMed id 17848914)^{1, 3} Savage S.A....Garcia-Closas M. (2007)
Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines. (PubMed id 12792796)¹ Miracco C....Tosi P. (2003)
Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopoietic cells. (PubMed id 10613358)¹ Uchida N....Niho Y. (1999)
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. (PubMed id 11149928)¹ Kickhoefer V.A....Rome L.H. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7011	HGNC: 11726	AceView: TEP1	Ensembl:ENSG00000129566	euGenes: HUgn7011
ECgene: TEP1	H-InvDB: TEP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TEP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TEP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TEP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TEP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TEP1		Antibodies for TEP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TEP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TEP1)
	Antibodies (TEP1)
	Chimera RNAi (TEP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TEP1)
	Antibodies (TEP1)

Search OriGene for TEP1

Search Tocris compounds for TEP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TEP1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TEP1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

TEP1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TEP1

Summaries
for TEP1

Genomic Location
for TEP1

Proteins
for TEP1

Protein Domains/
Families
for TEP1

Gene Function
for TEP1

Pathways & Interactions
for TEP1

Drugs & Compounds
for TEP1

Transcripts
for TEP1

Expression
for TEP1

Orthologs
for TEP1

Paralogs
for TEP1

SNPs/Variants
for TEP1

Disorders & Mutations
for TEP1

Medical News
for TEP1

Publications
for TEP1

Search for TEP1

Genome Databases showing TEP1

Other Databases showing TEP1

Specialized Databases showing TEP1

Licensable Technologies
for TEP1

Services
for TEP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TEP1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TEP1

Summariesfor TEP1

Genomic Locationfor TEP1

Proteinsfor TEP1

Protein Domains/Familiesfor TEP1

Gene Functionfor TEP1

Pathways & Interactionsfor TEP1

Drugs & Compoundsfor TEP1

Transcriptsfor TEP1

Expression for TEP1

Orthologsfor TEP1

Paralogsfor TEP1

SNPs/Variantsfor TEP1

Disorders & Mutationsfor TEP1

Medical Newsfor TEP1

Publicationsfor TEP1

Search for TEP1

Genome Databases showing TEP1

Other Databases showing TEP1

Specialized Databases showing TEP1

Licensable Technologiesfor TEP1

Servicesfor TEP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TEP1

Summaries
for TEP1

Genomic Location
for TEP1

Proteins
for TEP1

Protein Domains/
Families
for TEP1

Gene Function
for TEP1

Pathways & Interactions
for TEP1

Drugs & Compounds
for TEP1

Transcripts
for TEP1

Expression
for TEP1

Orthologs
for TEP1

Paralogs
for TEP1

SNPs/Variants
for TEP1

Disorders & Mutations
for TEP1

Medical News
for TEP1

Publications
for TEP1

Licensable Technologies
for TEP1

Services
for TEP1