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Aliases for TEP1 Gene

Aliases for TEP1 Gene

  • Telomerase-Associated Protein 1 2 3 4
  • TP1 3 4 6
  • P80 Telomerase Homolog 3 4
  • Telomerase Protein 1 3 4
  • P240 3 4
  • TLP1 3 4
  • Telomerase Protein Component 1 3
  • TROVE Domain Family, Member 1 3
  • TROVE Domain Family 2
  • Member 1 2
  • TROVE1 3
  • VAULT2 3

External Ids for TEP1 Gene

Previous GeneCards Identifiers for TEP1 Gene

  • GC14M018206
  • GC14M014623
  • GC14M018826
  • GC14M019903
  • GC14M020833
  • GC14M000955

Summaries for TEP1 Gene

Entrez Gene Summary for TEP1 Gene

  • This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEP1 Gene

TEP1 (Telomerase-Associated Protein 1) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include RNA binding and telomerase activity. An important paralog of this gene is TBL3.

UniProtKB/Swiss-Prot for TEP1 Gene

  • Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).

Gene Wiki entry for TEP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEP1 Gene

Genomics for TEP1 Gene

Regulatory Elements for TEP1 Gene

Genomic Location for TEP1 Gene

Start:
20,365,667 bp from pter
End:
20,414,172 bp from pter
Size:
48,506 bases
Orientation:
Minus strand

Genomic View for TEP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEP1 Gene

Proteins for TEP1 Gene

  • Protein details for TEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99973-TEP1_HUMAN
    Recommended name:
    Telomerase protein component 1
    Protein Accession:
    Q99973
    Secondary Accessions:
    • A0AUV9

    Protein attributes for TEP1 Gene

    Size:
    2627 amino acids
    Molecular mass:
    290490 Da
    Quaternary structure:
    • Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity).

    Alternative splice isoforms for TEP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEP1 Gene

Proteomics data for TEP1 Gene at MOPED

Post-translational modifications for TEP1 Gene

  • Ubiquitination at Lys633
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TEP1 Gene

Domains for TEP1 Gene

Gene Families for TEP1 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TEP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99973

UniProtKB/Swiss-Prot:

TEP1_HUMAN :
  • Q99973
Domain:
  • Contains 1 NACHT domain.
  • Contains 1 TROVE domain.
Similarity:
  • Contains 4 TEP1 N-terminal repeats.
  • Contains 21 WD repeats.
genes like me logo Genes that share domains with TEP1: view

Function for TEP1 Gene

Molecular function for TEP1 Gene

GENATLAS Biochemistry: telomerase protein component 1
UniProtKB/Swiss-Prot Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).

Gene Ontology (GO) - Molecular Function for TEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003720 contributes_to telomerase activity IDA 12135483
GO:0003723 RNA binding ISS --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TEP1: view

Phenotypes for TEP1 Gene

MGI mutant phenotypes for TEP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for TEP1:
genes like me logo Genes that share phenotypes with TEP1: view

Animal Models for TEP1 Gene

MGI Knock Outs for TEP1:

Animal Model Products

CRISPR Products

miRNA for TEP1 Gene

miRTarBase miRNAs that target TEP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TEP1 Gene

Localization for TEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEP1 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEP1 Gene COMPARTMENTS Subcellular localization image for TEP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005697 telomerase holoenzyme complex IDA 12135483
GO:0005737 cytoplasm IDA 7876352
GO:0016363 nuclear matrix IDA 7876352
GO:0030529 ribonucleoprotein complex TAS 15701761
genes like me logo Genes that share ontologies with TEP1: view

Pathways for TEP1 Gene

genes like me logo Genes that share pathways with TEP1: view

Pathways by source for TEP1 Gene

1 Qiagen pathway for TEP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination IDA 10810353
GO:0006278 RNA-dependent DNA replication IDA 12135483
genes like me logo Genes that share ontologies with TEP1: view

Compounds for TEP1 Gene

(4) Novoseek inferred chemical compound relationships for TEP1 Gene

Compound -log(P) Hits PubMed IDs
tin(2+) 80.2 4
adpribose 47.2 4
retinoic acid 28.9 1
paraffin 0.753 2
genes like me logo Genes that share compounds with TEP1: view

Transcripts for TEP1 Gene

Unigene Clusters for TEP1 Gene

Telomerase-associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TEP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b · 49c ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54a · 54b · 54c ^ 55a · 55b ^ 56a · 56b · 56c ^ 57
SP1:
SP2: -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:

Relevant External Links for TEP1 Gene

GeneLoc Exon Structure for
TEP1
ECgene alternative splicing isoforms for
TEP1

Expression for TEP1 Gene

mRNA expression in normal human tissues for TEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEP1 Gene

SOURCE GeneReport for Unigene cluster for TEP1 Gene Hs.508835

mRNA Expression by UniProt/SwissProt for TEP1 Gene

Q99973-TEP1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TEP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TEP1 Gene

Orthologs for TEP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEP1 35
  • 99.15 (n)
  • 98.45 (a)
TEP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEP1 35
  • 84.45 (n)
  • 80.21 (a)
TEP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEP1 35
  • 78.19 (n)
  • 72.91 (a)
TEP1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tep1 35
  • 80.1 (n)
  • 75.82 (a)
Tep1 16
Tep1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEP1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEP1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tep1 35
  • 79.9 (n)
  • 75.36 (a)
lizard
(Anolis carolinensis)
Reptilia TEP1 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485265 35
  • 49.45 (n)
  • 41.03 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-284o19.1 35
  • 49.92 (n)
  • 41.12 (a)
TEP1 36
  • 24 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1671 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C12B.1 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP13 36
  • 14 (a)
OneToMany
Species with no ortholog for TEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEP1 Gene

ENSEMBL:
Gene Tree for TEP1 (if available)
TreeFam:
Gene Tree for TEP1 (if available)

Paralogs for TEP1 Gene

Paralogs for TEP1 Gene

genes like me logo Genes that share paralogs with TEP1: view

Variants for TEP1 Gene

Sequence variations from dbSNP and Humsavar for TEP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs872072 -- 20,390,854(+) GTATT(A/G)TCTGT intron-variant
rs872073 -- 20,390,925(+) GGGTG(C/T)TGAGT intron-variant
rs872074 -- 20,391,046(+) TGCTC(C/T)GCCCT synonymous-codon, reference, nc-transcript-variant
rs938886 - 20,369,542(+) CATAG(C/G)ATCCC reference, missense, nc-transcript-variant
rs938887 -- 20,379,043(+) AGTGT(A/G)TCATC synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TEP1 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Relevant External Links for TEP1 Gene

HapMap Linkage Disequilibrium report
TEP1
Human Gene Mutation Database (HGMD)
TEP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEP1 Gene

Disorders for TEP1 Gene

(23) Novoseek inferred disease relationships for TEP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 33.6 6
endometrial hyperplasia 33.5 1
cancer 33.3 9
gastric carcinoma 30.7 3
gastric cancer 30.5 2

Relevant External Links for TEP1

Genetic Association Database (GAD)
TEP1
Human Genome Epidemiology (HuGE) Navigator
TEP1
genes like me logo Genes that share disorders with TEP1: view

No data available for UniProtKB/Swiss-Prot for TEP1 Gene

Publications for TEP1 Gene

  1. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. (PMID: 11029039) Beattie T.L. … Harrington L. (Mol. Biol. Cell 2000) 3 4 23
  2. Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. (PMID: 9403057) Saito T. … Ishikawa F. (Genomics 1997) 2 3 23
  3. Vaults and telomerase share a common subunit, TEP1. (PMID: 10551828) Kickhoefer V.A. … Rome L.H. (J. Biol. Chem. 1999) 3 4 23
  4. A mammalian telomerase-associated protein. (PMID: 9020079) Harrington L. … Robinson M.O. (Science 1997) 3 4 23
  5. Genetic variation in five genes important in telomere biology and risk for breast cancer. (PMID: 17848914) Savage S.A. … Garcia-Closas M. (Br. J. Cancer 2007) 3 23 48

Products for TEP1 Gene

Sources for TEP1 Gene

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