Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TEP1 Gene

protein-coding GIFtS: 57
GCID: GC14M020833

telomerase-associated protein 1

Explore 41 diseases affiliated with
TEP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Telomerase-Associated Protein 1¹ ² ³		VAULT2¹ ²
TP1¹ ² ³ ⁵		Telomerase Protein 1² ³
TLP1¹ ² ³		P80 Telomerase Homolog² ³
P240¹		Telomerase Protein Component 1²
TROVE1¹ ²		TROVE Domain Family, Member 1²

External Ids:	HGNC: 11726¹	Entrez Gene: 7011²	Ensembl: ENSG00000129566⁷	OMIM: 601686⁵	UniProtKB: Q99973³

Export aliases for TEP1 gene to outside databases

Previous GC identifers: GC14M018206 GC14M014623 GC14M018826 GC14M019903 GC14M000955

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEP1:

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes

the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates

to humans. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome

termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in

nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault

ribonucleoprotein particle. Binds to TERC (By similarity)

Gene Wiki entry for TEP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TEP1 gene promoter:
E2F-3a E2F-4 Elk-1 E2F-5 AML1a Pax-5 E2F-2 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEP1 promoter sequence

Search SABiosciences Chromatin IP Primers for TEP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

TEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEP1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M020833: view genomic region (about GC identifiers)

Start:	20,833,826 bp from pter	End:	20,881,588 bp from pter
Size:	47,763 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973 (See protein sequence)

Recommended Name: Telomerase protein component 1

Size: 2627 amino acids; 290490 Da

Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2,

GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein

particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and

VAULTRC4/hvg4 vRNAs (By similarity)

Subcellular location: Nucleus (Probable). Chromosome, telomere

Secondary accessions: A0AUV9

Alternative splicing: 2 isoforms: Q99973-1 Q99973-2 (May be due to an exon inclusion)

Explore the universe of human proteins at neXtProt for TEP1: NX_Q99973

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99973

TEP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_009041.2

ENSEMBL proteins:

ENSP00000450475 ENSP00000262715 ENSP00000450541 ENSP00000451634 ENSP00000452574

ENSP00000450508 ENSP00000450830 ENSP00000451409 ENSP00000451919 ENSP00000452240

ENSP00000438849

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TEP1
	GenScript Custom Purified and Recombinant Proteins Services for TEP1
	Novus Biologicals TEP1 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TEP1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000781	chromosome, telomeric region	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005697	telomerase holoenzyme complex	IDA	12135483
GO:0005737	cytoplasm	IDA	7876352
GO:0016363	nuclear matrix	IDA	7876352

TEP1 for ontologies About GeneDecksing

TEP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TEP1 OriGene Custom Antibody Services for TEP1
	GenScript Custom Superior Antibodies Services for TEP1
	Novus Biologicals TEP1 Antibodies
	Search for Antibodies for TEP1 at Abcam
	Uscn Antibodies for TEP1
	ThermoFisher Antibodies for TEP1

Assay Products for TEP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TEP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TEP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TEP1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR007111 NACHT_NTPase

IPR008850 TEP1_N

IPR019775 WD40_repeat_CS

IPR008858 TROVE

IPR001680 WD40_repeat

Graphical View of Domain Structure for InterPro Entry Q99973

ProtoNet protein and cluster: Q99973

2 Blocks protein families:

IPB001680 G-protein beta WD-40 repeat signature

IPB008858 TROVE

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Similarity: Contains 1 NACHT domain

Similarity: Contains 4 TEP1 N-terminal repeats

Similarity: Contains 1 TROVE domain

Similarity: Contains 21 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome

termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in

nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault

ribonucleoprotein particle. Binds to TERC (By similarity)

Genatlas biochemistry entry for TEP1:

telomerase protein component 1

miRNA Products:		OriGene 3'-UTR Clone: TEP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEP1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TEP1 (see all 12):
		hsa-miR-148b* hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-554 hsa-miR-624 hsa-miR-628-3p hsa-miR-3155 hsa-miR-484

		SwitchGear 3'UTR luciferase reporter plasmid: TEP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEP1 (see all 7) OriGene shRNA RFP: TEP1 OriGene siRNA: TEP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TEP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TEP1 (NM_007110)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TEP1
		Search LifeMap BioReagents cell lines for TEP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEP1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003720	contributes to telomerase activity	IDA	12135483
GO:0003723	RNA binding	ISS	--
GO:0005524	ATP binding	IEA	--

TEP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TEP1:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Tep1^tm1Leah for TEP1
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tep1):

normal

TEP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

Telomerase Components in Cell Signaling

0.72

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TEP1

Telomerase Components in Cell Signaling

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TEP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for TEP1 (Q99973³ ENSP00000262715⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637³, ENSP00000269305⁴	I2D: score=3 STRING: ENSP00000269305
TERT	O14746³, ENSP00000309572⁴	I2D: score=2 STRING: ENSP00000309572
PRKCA	P17252³, ENSP00000284384⁴	I2D: score=2 STRING: ENSP00000284384
ATN1	P54259³, ENSP00000349076⁴	I2D: score=2 STRING: ENSP00000349076
CAV1	ENSP00000339191⁴	STRING: ENSP00000339191

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000722	telomere maintenance via recombination	IDA	10810353

TEP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TEP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TEP1
4 Novoseek chemical compound relationships for TEP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	80.2	4	12007281 (2), 11494028 (1), 17616810 (1)
adpribose	47.2	4	11494028 (1), 18759128 (1), 12007281 (1), 11085454 (1)
retinoic acid	28.9	2	11777343 (1)
paraffin	0.753	2	17066600 (1), 8605397 (1)

Search CenterWatch for drugs/clinical trials and news about TEP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TEP1 gene:

NM_007110.4

Unigene Cluster for TEP1:

Telomerase-associated protein 1

Hs.508835 [show with all ESTs]

Unigene Representative Sequence: NM_007110

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553365 ENST00000262715(uc010ahj.1 uc010ahk.3 uc001vxe.3 uc010tlf.1 uc010tlg.1)

ENST00000555008(uc010tlh.1) ENST00000555727 ENST00000556935 ENST00000553984

ENST00000557314 ENST00000556488 ENST00000471684 ENST00000557627 ENST00000556549

ENST00000545983

miRNA Products:		OriGene 3'-UTR Clone: TEP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEP1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TEP1 (see all 12):
		hsa-miR-148b* hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-554 hsa-miR-624 hsa-miR-628-3p hsa-miR-3155 hsa-miR-484

		SwitchGear 3'UTR luciferase reporter plasmid: TEP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEP1 (see all 7) OriGene shRNA RFP: TEP1 OriGene siRNA: TEP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TEP1 (NM_007110)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TEP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEP1

Additional cDNA sequence:

AB209669.1 AK124360.1 AK303307.1 BC126107.1 BC143812.1 BC143815.1 BX640983.1 U86136.2

10 DOTS entries:

DT.40117791 DT.99991901 DT.97845575 DT.86848766 DT.100659440 DT.92422291 DT.40192344 DT.92050248

DT.92009363 DT.95245860

24/114 AceView cDNA sequences (see all 114):

BM810250 AI476293 BU521152 BM556823 BM555079 BU543910 AI867200 CA422831

AA722421 CF147492 BQ304178 BM555913 BM676849 BQ957505 AK124360 N58857

BF197089 CK823973 BM556329 BE739840 BQ021178 NM_007110 AW054694 AI040596

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TEP1 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39a	·	39b	^	40a	·	40b	^	41	^	42	^	43	^	44	^	45	^
SP1:
SP2:											-
SP3:
SP4:																																							-
SP5:

ExUns:	46	^	47	^	48	^	49a	·	49b	·	49c	^	50	^	51a	·	51b	^	52	^	53	^	54a	·	54b	·	54c	^	55a	·	55b	^	56a	·	56b	·	56c	^	57
SP1:
SP2:																													-
SP3:																							-												-		-
SP4:
SP5:

ECgene alternative splicing isoforms for TEP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TEP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTAGTGCC

About this image

TEP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

ES-J1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Long-time differentiated EBs (Derivation of embryo...)

See TEP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TEP1

SOURCE GeneReport for Unigene cluster: Hs.508835

UniProtKB/Swiss-Prot: TEP1_HUMAN, Q99973

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including TEP1:

Cancer PathwayFinder in human mouse rat

Telomeres & Telomerase in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TEP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TEP1 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tep1^{1 , 5}	telomerase associated protein 1^{1, 5}	80.1(n)¹ 75.82(a)¹		14 (26.26 cM)⁵ 21745¹ NM_009351.2¹ NP_033377.1¹ 93267257⁵
lizard (Anolis carolinensis)	Reptilia	TEP1⁶	--	42(a)	1 ↔ 1	GL343220.1(1075028-1115951)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-284o19.1¹	si:ch211-284o19.1	48.26(n) 39.87(a)		100321823 XM_002660857.2 XP_002660903.2

ENSEMBL Gene Tree for TEP1 (if available)
TreeFam Gene Tree for TEP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TEP1 gene

TBL3²

2 SIMAP similar genes for TEP1 using alignment to 12 protein entries: TEP1_HUMAN (see all proteins):

GNB5 POC1B

TEP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139150954^1,2	C,	--	20833427(+)	`CTTTC-/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs1760911^1,2	A	--	20833434(-)	`aaaagA/Gaaaaa`	1	--	ds500¹		0	--	--	--	--
rs8014515^1,2	C,F,H,	--	20833462(+)	`agtttC/Gattct`	1	--	ds500¹		4		NS EA	416
rs190909161^1,2		--	20833496(+)	`GATGCA/GATCTC`	1	--	ds500¹		0	--	--	--	--
rs8014644^1,2	C,	--	20833515(+)	`gcaacA/Ctctgc`	1	--	ds500¹		0	--	--	--	--
rs8007377^1,2	C,	--	20833525(+)	`cccccC/Tgagtt`	1	--	ds500¹		0	--	--	--	--
rs8018816^1,2	C,	--	20833526(+)	`cccctA/Gagttc`	1	--	ds500¹		0	--	--	--	--
rs191784339^1,2		--	20833625(+)	`GACGGG/TGTTTC`	1	--	ds500¹		0	--	--	--	--
rs144403421^1,2		--	20833653(+)	`CGCCTC/TGAACT`	1	--	ds500¹		0	--	--	--	--
rs8018974^1,2	C,F,H,	--	20833654(+)	`gcctcG/Aaactc`	1	--	ds500¹		5		NS EA WA	534

HapMap Linkage Disequilibrium report for TEP1 (20833826 - 20881588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TEP1
1 CNV: 71865
Human Gene Mutation Database (HGMD): TEP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEP1

DNA2.0 Custom Variant and Variant Library Synthesis for TEP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TEP1 for disorders           About GeneDecksing

OMIM gene information: 601686    OMIM disorders: --

20/41 diseases for TEP1 (see all 41):    About MalaCards

bannayan-riley-ruvalcaba syndrome ruvalcaba syndrome squamous cell carcinoma urinary bladder cancer

oral squamous cell carcinoma esophageal squamous cell carcinoma benign tumors cowden disease

chronic lymphocytic leukemia intrahepatic cholangiocarcinoma lymphocytic leukemia pituitary adenoma

ulcerative colitis malignant glioma endometrial cancer cerebrovascular disease

hepatocellular carcinoma keratosis gastric cancer carcinoma

10/23 Novoseek disease relationships for TEP1 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	33.6	6	11494028 (1), 9935231 (1), 12943625 (1), 12970299 (1) (see all 6)
endometrial hyperplasia	33.5	1	11820598 (1)
cancer	33.3	9	9537264 (2), 14621192 (1), 9676833 (1), 10568811 (1) (see all 8)
gastric carcinoma	30.7	3	11494028 (1), 12007281 (1), 9914776 (1)
gastric cancer	30.5	3	11343177 (1), 16696344 (1)
carcinoma squamous cell	25.4	6	8425208 (1), 11167139 (1), 15112252 (1), 10568811 (1) (see all 5)
leukemia	25.3	3	9753073 (1), 15165114 (1), 11877056 (1)
benign tumor	22.6	1	12440093 (1)
glioblastoma	20.4	2	9874800 (1), 17196947 (1)
acute leukemia	18.9	1	11877056 (1)

Human Genome Epidemiology (HuGE) Navigator: TEP1 (95 documents)

Export disorders for TEP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TEP1 gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with TEP1)

Utopia: connect your pdf to the dynamic
world of online information

Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. (PubMed id 9403057)^{1, 3, 9} Saito T....Ishikawa F. (1997)
Vaults and telomerase share a common subunit, TEP1. (PubMed id 10551828)^{1, 2, 9} Kickhoefer V.A....Rome L.H. (1999)
A mammalian telomerase-associated protein. (PubMed id 9020079)^{1, 2, 9} Harrington L.... Robinson M.O. (1997)
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. (PubMed id 11029039)^{1, 2, 9} Beattie T.L.... Harrington L. (2000)
Human telomerase contains evolutionarily conserved catalytic and structural subunits. (PubMed id 9389643)^{1, 2} Harrington L.... Robinson M.O. (1997)
Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. (PubMed id 14606063)^{1, 9} Li C....Wu X.Y. (2003)
Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. (PubMed id 10810353)^{1, 9} Koyanagi Y....Watanabe N. (2000)
Telomerase-associated Protein 1, HSP90, and Topoisomerase II{alpha} Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates. (PubMed id 19329795)^{1, 9} Bhattacharyya S....Groden J. (2009)
Polymorphisms in telomere-associated genes, breast ca ncer susceptibility and prognosis. (PubMed id 19766477)^{1, 9} Varadi V....FAPrsti A. (2009)
Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. (PubMed id 10597287)^{1, 9} Li H....Liu J.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7011	HGNC: 11726	AceView: TEP1	Ensembl:ENSG00000129566	euGenes: HUgn7011
ECgene: TEP1	H-InvDB: TEP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TEP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TEP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TEP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TEP1 gene:
Search GeneIP for patents involving TEP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TEP1		OriGene shRNA RFP for TEP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEP1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TEP1		OriGene 3'-UTR Clone for TEP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TEP1		OriGene Custom Protein Services for TEP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEP1

	GenScript Custom Purified and Recombinant Proteins Services for TEP1		GenScript cDNA clones with any tag delivered in your preferred vector for TEP1
	GenScript Custom Assay Services for TEP1		GenScript Custom Superior Antibodies Services for TEP1
	GenScript Custom overexpressing Cell Line Services for TEP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TEP1 promoter
	Search Chromatin IP Primers for TEP1
	RT² qPCR Primer Assay in human, mouse, rat TEP1
	GNC Network for TEP1
	SABiosciences PCR Arrays including human, mouse, rat TEP1

Search Tocris compounds for TEP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TEP1 antibodies
	TEP1 proteins

	Search for Antibodies for TEP1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TEP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TEP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TEP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEP1

	SwitchGear 3'UTR luciferase reporter plasmids for TEP1
	SwitchGear Promoter luciferase reporter plasmids for TEP1

ThermoFisher Antibodies for TEP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEP1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TEP1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TEP1 Gene

telomerase-associated protein 1

Aliases
for TEP1 gene

Summaries
for TEP1 gene

Genomic Views
for TEP1 gene

Proteins
for TEP1 gene

Protein Domains /
Families
for TEP1 gene

Function
for TEP1 gene

Pathways & Interactions
for TEP1 gene

Drugs & Compounds
for TEP1 gene

Transcripts
for TEP1 gene

Expression
for TEP1 gene

Orthologs
for TEP1 gene

Paralogs
for TEP1 gene

Genomic Variants
for TEP1 gene

Disorders / Diseases
for TEP1 gene

Publications
for TEP1 gene

External Searches for TEP1 gene

Genome Databases showing TEP1 gene

Other Databases showing TEP1 gene

Specialized Databases showing TEP1 gene

Intellectual Property
for TEP1 gene

Products
for TEP1 gene

View Random Gene

Lymphoma
Gastric Cancer
GASTRIC CARCINOMA
bladder cancer
Glioma
Inflammation
benign tumor
dysplasia
Carcinoma
Carcinoma Squamous Cell
ACUTE LEUKEMIA
Leukemia
Breast Cancer
Tumors
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
Endometrial Hyperplasia
Cancer
Glioblastoma
premalignant
Pancreatic Cancer
Cancer Lung
Endometrial Cancer

Advanced Search

Export list of displayed genes

TEP1 Gene

telomerase-associated protein 1

Aliasesfor TEP1 gene

Summariesfor TEP1 gene

Genomic Viewsfor TEP1 gene

Proteinsfor TEP1 gene

Protein Domains /Familiesfor TEP1 gene

Functionfor TEP1 gene

Pathways & Interactionsfor TEP1 gene

Drugs & Compoundsfor TEP1 gene

Transcriptsfor TEP1 gene

Expression for TEP1 gene

Orthologsfor TEP1 gene

Paralogsfor TEP1 gene

Genomic Variantsfor TEP1 gene

Disorders / Diseasesfor TEP1 gene

Publicationsfor TEP1 gene

External Searches for TEP1 gene

Genome Databases showing TEP1 gene

Other Databases showing TEP1 gene

Specialized Databases showing TEP1 gene

Intellectual Propertyfor TEP1 gene

Productsfor TEP1 gene

View Random Gene

Aliases
for TEP1 gene

Summaries
for TEP1 gene

Genomic Views
for TEP1 gene

Proteins
for TEP1 gene

Protein Domains /
Families
for TEP1 gene

Function
for TEP1 gene

Pathways & Interactions
for TEP1 gene

Drugs & Compounds
for TEP1 gene

Transcripts
for TEP1 gene

Expression
for TEP1 gene

Orthologs
for TEP1 gene

Paralogs
for TEP1 gene

Genomic Variants
for TEP1 gene

Disorders / Diseases
for TEP1 gene

Publications
for TEP1 gene

Intellectual Property
for TEP1 gene

Products
for TEP1 gene