Aliases for TENM3 Gene
External Ids for TENM3 Gene
Previous HGNC Symbols for TENM3 Gene
Previous GeneCards Identifiers for TENM3 Gene
This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
GeneCards Summary for TENM3 Gene
TENM3 (Teneurin Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with TENM3 include Microphthalmia, Isolated, With Coloboma 9 and Colobomatous Microphthalmia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is TENM4.
UniProtKB/Swiss-Prot for TENM3 Gene
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).