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TENM3 Gene

protein-coding   GIFtS: 45
GCID: GC04P183067

Teneurin Transmembrane Protein 3

(Previous names: odz, odd Oz/ten-m homolog 3 (Drosophila))
(Previous symbol: ODZ3)
  See TENM3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Teneurin Transmembrane Protein 31 2 3     Odd Oz/Ten-M Homolog 32
ODZ31 2 3 5     Odz, Odd Oz/Ten-M Homolog 32
TNM32 3 5     ODZ3-Like Protein2
Protein Odd Oz/Ten-M Homolog 32 3     ten-32
Ten-m32 3     tenascin-M32
MCOPCB92 5     teneurin-32
KIAA14553 5     Ten-33
Odz, Odd Oz/Ten-M Homolog 3 (Drosophila)1     Tenascin-M33

External Ids:    HGNC: 299441   Entrez Gene: 557142   Ensembl: ENSG000002183367   OMIM: 6100835   UniProtKB: Q9P2733   

Export aliases for TENM3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TENM3 Gene:
TENM3 (teneurin transmembrane protein 3) is a protein-coding gene. Diseases associated with TENM3 include matthew-wood syndrome. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is TENM2.

UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous
system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual
pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus
(dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in
the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal
transducer (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TENM3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TENM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TENM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q34.3   HGNC cytogenetic band: 4q35

TENM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENM3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P183067:  view genomic region     (about GC identifiers)

Start:
183,065,140 bp from pter      End:
183,724,177 bp from pter
Size:
659,038 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273 (See protein sequence)
Recommended Name: Teneurin-3  
Size: 2699 amino acids; 300950 Da
Subunit: Homodimer; disulfide-linked (Probable)
Sequence caution: Sequence=BAA91633.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91879.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55138.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5XUL9 Q96SY2 Q9NV77 Q9NVW1 Q9NZJ2

Explore the universe of human proteins at neXtProt for TENM3: NX_Q9P273

Explore proteomics data for TENM3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn345, Asn380, Asn419, Asn670, Asn860, Asn883, Asn1202, Asn1527, Asn1544, Asn1640,
                                 Asn1677, Asn1735, Asn1820, Asn1921, Asn2124, Asn2264, Asn2576
  • Modification sites at PhosphoSitePlus

  • See TENM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073946.1  
    ENSEMBL proteins: 
     ENSP00000421320   ENSP00000424226   ENSP00000426914   ENSP00000385276  

    TENM3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TENM3

     
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    Search eBioscience for ELISAs for TENM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR022385 Rhs_assc_core
     IPR000742 EG-like_dom
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013032 EGF-like_CS
     IPR008969 CarboxyPept-like_regulatory

    Graphical View of Domain Structure for InterPro Entry Q9P273

    ProtoNet protein and cluster: Q9P273

    1 Blocks protein domain: IPB011070 Globular protein

    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
    Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of
    intermolecular disulfide bonds
    Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins
    Similarity: Belongs to the tenascin family. Teneurin subfamily
    Similarity: Contains 8 EGF-like domains
    Similarity: Contains 5 NHL repeats
    Similarity: Contains 1 teneurin N-terminal domain
    Similarity: Contains 23 YD repeats


    Find genes that share domains with TENM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEN3_HUMAN, Q9P273
    Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous
    system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual
    pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus
    (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in
    the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal
    transducer (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0009055electron carrier activity ----
    GO:0020037heme binding ----
    GO:0042803protein homodimerization activity ISS--
    GO:0046982protein heterodimerization activity ISS--
         
    Find genes that share ontologies with TENM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TENM3:
     Increased G2M DNA content, inc 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tenm3):
     behavior/neurological  mortality/aging  nervous system 

    Find genes that share phenotypes with TENM3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tenm3tm1Cal for TENM3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TENM3
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    miRTarBase miRNAs that target TENM3:
    hsa-let-7b-5p (MIRT052084), hsa-mir-10a-5p (MIRT047712), hsa-mir-10b-5p (MIRT047456)

    Block miRNA regulation of human, mouse, rat TENM3 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat TENM3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEN3_HUMAN, Q9P273: Membrane; Single-pass membrane protein (Probable). Cell projection, axon (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ISS--
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--

    Find genes that share ontologies with TENM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TENM3
    Interactions:

        Search GeneGlobe Interaction Network for TENM3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for TENM3 (Q9P2732, 3 ENSP000003852764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3MINT-61956 I2D: score=3 
    GABARAPL1Q9H0R83I2D: score=1 
    IRS1P355683I2D: score=1 
    MTERFQ995513I2D: score=1 
    PDPK1O155303I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS--
    GO:0007165signal transduction IEA--
    GO:0010976positive regulation of neuron projection development ISS--

    Find genes that share ontologies with TENM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TENM3 (TEN3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TENM3 gene: 
    NM_001080477.2  

    Unigene Cluster for TENM3:

    Teneurin transmembrane protein 3
    Hs.130438  [show with all ESTs]
    Unigene Representative Sequence: NM_001080477
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513201(uc010irv.1) ENST00000512480 ENST00000511685(uc021xux.1 uc003ivd.1)
    ENST00000510504 ENST00000502950(uc003ive.1) ENST00000507737 ENST00000406950

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TENM3
      QuantiFast Probe-based Assays in human, mouse, rat TENM3

    Additional mRNA sequence: 

    AB040888.2 AF195420.1 AK001336.1 AK001748.1 AK027473.1 AK125869.1 AK308489.1 AY726602.1 
    HE578284.1 HE578285.1 

    9 DOTS entries:

    DT.414355  DT.91653058  DT.40205558  DT.91692138  DT.121272674  DT.102829045  DT.97763390  DT.75106953 
    DT.95260704 

    Selected AceView cDNA sequences (see all 92):

    BE382393 AI820014 AU124680 CA454304 AB040888 AU119743 AA903519 AA236806 
    AK027473 CB106684 AI191088 AI288227 BM931190 AU133387 BM670316 BM712036 
    AK125869 CA777388 AU126844 AA449172 AI080208 F07757 BQ892798 Z40842 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TENM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TENM3 Expression
    About this image


    TENM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Heart (Cardiovascular System)
     
     Fibroblasts (Uncategorized)
    TENM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TENM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130438

    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
    Tissue specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and
    intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was
    high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TENM3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tenm31 , 5 odd Oz/ten-m homolog 3 (Drosophila)5
    teneurin transmembrane protein 31
    89(n)1
    98.33(a)1
      8 (27.02 cM)5
    239651  NM_001145937.11  NP_001139409.11 
     482276825 
    chicken
    (Gallus gallus)
    Aves ODZ31 odz, odd Oz/ten-m homolog 3 (Drosophila) 84.24(n)
    96.48(a)
      422557  NM_001198537.1  NP_001185466.1 
    lizard
    (Anolis carolinensis)
    Reptilia TENM36
    teneurin transmembrane protein 3
    94(a)
    1 ↔ 1
    GL343510.1(133873-391034)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85062 Xenopus laevis transcribed sequence with weak similarity more 72.58(n)    AW158470.1 
    zebrafish
    (Danio rerio)
    Actinopterygii odz32 odd Oz/ten-m homolog 3 76.29(n)   30155  AB026979.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ten-a1 Tenascin accessory 46.21(n)
    35.17(a)
      32183  NM_001258712.1  NP_001245641.1 


    ENSEMBL Gene Tree for TENM3 (if available)
    TreeFam Gene Tree for TENM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TENM3 gene
    TENM22  WIF12  TENM12  TENM42  VWDE2  
    7 SIMAP similar genes for TENM3 using alignment to 3 protein entries:     TEN3_HUMAN (see all proteins):
    ODZ3    TENM4    TENM2    ODZ2    TENM1    ODZ4
    ODZ1

    Find genes that share paralogs with TENM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TENM3 (see all 10445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118515311,2
    C--179441958(+) AAAAA-/AGAAAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs285624991,2
    C,F--183243184(+) CCTTTG/TGTATA 1 -- us2k13Minor allele frequency- T:0.19WA NA EA 358
    rs284793241,2
    C,F--183243354(+) TTTTTA/TAAATA 1 -- us2k13Minor allele frequency- T:0.18WA NA EA 358
    rs284508141,2
    C,F--183243364(+) AAAAAC/TCAAAT 1 -- us2k13Minor allele frequency- T:0.18WA NA EA 358
    rs1163704741,2
    F--183243409(+) ATATAT/ATCCAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1455435521,2
    --183243415(+) TCCAAA/GACTAA 1 -- us2k10--------
    rs68159631,2
    C,F--183243416(+) CCAAGA/CCTAAA 1 -- us2k14Minor allele frequency- C:0.15NA WA 242
    rs1903225091,2
    --183243472(+) ATATCA/GGTATT 1 -- us2k10--------
    rs779194761,2
    C,F--183243494(+) AAATAT/CGGAAC 1 -- us2k11Minor allele frequency- C:0.14WA 118
    rs1381020921,2
    C--183243504(+) CCCCAA/CAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TENM3 (183065140 - 183315140 bp, first 250kb of TENM3)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TENM3: --
    Human Gene Mutation Database (HGMD): TENM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TENM3
    DNA2.0 Custom Variant and Variant Library Synthesis for TENM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610083   
    OMIM disorders: 615145  
    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
  • Microphthalmia, isolated, with coloboma, 9 (MCOPCB9) [MIM:615145]: A disorder of eye formation, ranging
    from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like
    opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
    Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and
    the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 1 disease for TENM3:    
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    matthew-wood syndrome


    Find genes that share disorders with TENM3           About GenesLikeMe


    Export disorders for TENM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TENM3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TENM3)
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    1. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PubMed id 10625539)1, 2, 3 Ben-Zur T.... Wides R. (Dev. Biol. 2000)
    2. Homozygous null mutation in ODZ3 causes microphthalmia in humans. (PubMed id 22766609)1, 2 Aldahmesh M.A.... Alkuraya F.S. (Genet. Med. 2012)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. (PubMed id 10331952)1, 3 Ben-Zur T. and Wides R. (Genomics 1999)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. (PubMed id 24058526)1 Bhatnagar P....Arking D.E. (PLoS ONE 2013)
    9. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (PLoS ONE 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55714 HGNC: 29944 AceView: ODZ3 Ensembl:ENSG00000218336 euGenes: HUgn55714
    ECgene: TENM3 H-InvDB: TENM3

    (According to HUGE)
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    HUGE: KIAA1455

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TENM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TENM3 gene:
    Search GeneIP for patents involving TENM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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