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Aliases for TENM3 Gene

Aliases for TENM3 Gene

  • Teneurin Transmembrane Protein 3 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 3 3 4
  • Tenascin-M3 3 4
  • Ten-M3 3 4
  • Ten-3 3 4
  • ODZ3 3 4
  • TNM3 3 4
  • Odz, Odd Oz/Ten-M Homolog 3 (Drosophila) 2
  • Testicular Tissue Protein Li 195 3
  • Odz, Odd Oz/Ten-M Homolog 3 3
  • ODZ3-Like Protein 3
  • Teneurin-3 3
  • KIAA1455 4
  • MCOPCB9 3

External Ids for TENM3 Gene

Previous HGNC Symbols for TENM3 Gene

  • ODZ3

Previous GeneCards Identifiers for TENM3 Gene

  • GC04P183067

Summaries for TENM3 Gene

Entrez Gene Summary for TENM3 Gene

  • This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]

GeneCards Summary for TENM3 Gene

TENM3 (Teneurin Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with TENM3 include Microphthalmia, Isolated, With Coloboma 9 and Colobomatous Microphthalmia. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is TENM4.

UniProtKB/Swiss-Prot for TENM3 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM3 Gene

Genomics for TENM3 Gene

Regulatory Elements for TENM3 Gene

Enhancers for TENM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G182189 1.6 FANTOM5 Ensembl ENCODE 11.2 +45.9 45883 1.5 PKNOX1 FOXA2 MLX SIN3A ARID4B FEZF1 GLIS2 FOS KLF7 SP3 MIR1305 LOC90768 TENM3 ENSG00000248266 PIR41729 GC04P182170
GH04G182206 1 Ensembl ENCODE 11.1 +64.1 64083 3.4 NFIB JUN MAX RAD21 YY1 GATA3 GATA2 ZNF366 FOS MAFK TENM3 LOC90768 ENSG00000248266 LOC105377572 PIR41729
GH04G182179 0.6 Ensembl 11.3 +35.3 35314 0.2 ZNF335 JUND SMARCA4 CHD1 MAFK ZBTB7A NFE2L2 EZH2 LOC90768 ENSG00000248266 TENM3 GC04P182170 PIR41729
GH04G182554 1 Ensembl ENCODE 6.6 +411.9 411897 3.0 FOXA2 HINFP ZSCAN4 TEAD4 FEZF1 CEBPG CHD7 ZNF664 ZFHX2 ZNF316 TENM3 GC04P182552 GC04M182598
GH04G182560 1 Ensembl ENCODE 5.7 +416.6 416571 1.1 CTCF TEAD4 CHD7 ZIC2 ETS1 OSR2 JUND PRDM6 HDAC2 BCL11A TENM3 GC04P182552 GC04M182598
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TENM3 on UCSC Golden Path with GeneCards custom track

Promoters for TENM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176671 213 2801 FOXA2 ZNF493 ZNF133 GLI4 ZNF2 ZNF48 GLIS2 KLF7 ZNF263 SP3

Genomic Location for TENM3 Gene

Chromosome:
4
Start:
182,143,987 bp from pter
End:
182,803,024 bp from pter
Size:
659,038 bases
Orientation:
Plus strand

Genomic View for TENM3 Gene

Genes around TENM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM3 Gene

Proteins for TENM3 Gene

  • Protein details for TENM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P273-TEN3_HUMAN
    Recommended name:
    Teneurin-3
    Protein Accession:
    Q9P273
    Secondary Accessions:
    • Q5XUL9
    • Q96SY2
    • Q9NV77
    • Q9NVW1
    • Q9NZJ2

    Protein attributes for TENM3 Gene

    Size:
    2699 amino acids
    Molecular mass:
    300950 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAA91633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91879.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55138.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENM3 Gene

Post-translational modifications for TENM3 Gene

  • Glycosylation at Asn345, Asn380, Asn419, Asn670, isoforms=860, isoforms=883, isoforms=1202, posLast=15271527, Asn1544, Asn1640, isoforms=1677, isoforms=1735, posLast=18201820, Asn1921, Asn2124, Asn2264, and Asn2576
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TENM3 Gene

Domains & Families for TENM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P273

UniProtKB/Swiss-Prot:

TEN3_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
genes like me logo Genes that share domains with TENM3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TENM3 Gene

Function for TENM3 Gene

Molecular function for TENM3 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).

Gene Ontology (GO) - Molecular Function for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity ISS --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with TENM3: view
genes like me logo Genes that share phenotypes with TENM3: view

Human Phenotype Ontology for TENM3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TENM3 Gene

MGI Knock Outs for TENM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TENM3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TENM3 Gene

Localization for TENM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENM3 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TENM3: view

Pathways & Interactions for TENM3 Gene

SuperPathways for TENM3 Gene

No Data Available

Interacting Proteins for TENM3 Gene

Gene Ontology (GO) - Biological Process for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007165 signal transduction IEA --
GO:0010976 positive regulation of neuron projection development ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TENM3: view

No data available for Pathways by source and SIGNOR curated interactions for TENM3 Gene

Drugs & Compounds for TENM3 Gene

No Compound Related Data Available

Transcripts for TENM3 Gene

Unigene Clusters for TENM3 Gene

Teneurin transmembrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENM3 Gene

No ASD Table

Relevant External Links for TENM3 Gene

GeneLoc Exon Structure for
TENM3
ECgene alternative splicing isoforms for
TENM3

Expression for TENM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TENM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TENM3 Gene

This gene is overexpressed in Breast (44.3), Fetal Brain (12.3), and Placenta (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TENM3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TENM3 Gene:

TENM3

SOURCE GeneReport for Unigene cluster for TENM3 Gene:

Hs.130438

mRNA Expression by UniProt/SwissProt for TENM3 Gene:

Q9P273-TEN3_HUMAN
Tissue specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.

Evidence on tissue expression from TISSUES for TENM3 Gene

  • Nervous system(4.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TENM3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • skull
Thorax:
  • aorta
  • diaphragm
  • heart
  • heart valve
  • lung
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • testicle
  • ureter
  • uterus
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with TENM3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TENM3 Gene

Orthologs for TENM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TENM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODZ3 34
  • 99.31 (n)
TENM3 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TENM3 35
  • 98 (a)
OneToOne
ODZ3 34
  • 90.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TENM3 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM3 34 35
  • 92.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TENM3 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenm3 34
  • 89.07 (n)
mouse
(Mus musculus)
Mammalia Tenm3 34 16 35
  • 89 (n)
chicken
(Gallus gallus)
Aves ODZ3 34 35
  • 84.24 (n)
lizard
(Anolis carolinensis)
Reptilia TENM3 35
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8506 34
zebrafish
(Danio rerio)
Actinopterygii tenm3 34 35
  • 73.95 (n)
TENM3 (2 of 2) 35
  • 70 (a)
OneToMany
odz3 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000461 34
  • 46.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ten-a 34
  • 46.21 (n)
Species where no ortholog for TENM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM3 Gene

ENSEMBL:
Gene Tree for TENM3 (if available)
TreeFam:
Gene Tree for TENM3 (if available)

Paralogs for TENM3 Gene

Paralogs for TENM3 Gene

(7) SIMAP similar genes for TENM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TENM3: view

Variants for TENM3 Gene

Sequence variations from dbSNP and Humsavar for TENM3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs587776950 Pathogenic 182,688,213(+) GGGGA(-/A)CGTGT reference, frameshift-variant
rs886037853 Pathogenic 182,736,806(+) AACTT(A/T)GGTAC splice-acceptor-variant
rs375491156 Likely benign 182,751,938(+) GAAGT(C/T)GTCGC reference, synonymous-codon
rs571803780 Likely benign 182,792,585(+) TATGA(C/T)GAAAC reference, synonymous-codon
rs10866256 Benign 182,731,022(+) AATGA(C/T)ATTCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TENM3 Gene

Variant ID Type Subtype PubMed ID
dgv1049e214 CNV loss 21293372
dgv9411n54 CNV loss 21841781
dgv9412n54 CNV loss 21841781
dgv9413n54 CNV loss 21841781
dgv9414n54 CNV loss 21841781
esv1557171 CNV deletion 17803354
esv25967 CNV loss 19812545
esv2665003 CNV deletion 23128226
esv2666259 CNV deletion 23128226
esv2668164 CNV deletion 23128226
esv2668715 CNV deletion 23128226
esv2672888 CNV deletion 23128226
esv2728846 CNV deletion 23290073
esv2728847 CNV deletion 23290073
esv2759307 CNV loss 17122850
esv2762489 CNV loss 21179565
esv3305031 CNV mobile element insertion 20981092
esv3328475 CNV insertion 20981092
esv3367190 CNV insertion 20981092
esv3381724 CNV insertion 20981092
esv3430870 CNV insertion 20981092
esv3565130 CNV deletion 23714750
esv3569850 CNV loss 25503493
esv3603422 CNV loss 21293372
esv3603423 CNV loss 21293372
esv3603426 CNV loss 21293372
esv3603428 CNV loss 21293372
esv5240 CNV loss 18987735
esv7165 CNV loss 19470904
nsv1016288 CNV loss 25217958
nsv1020394 CNV loss 25217958
nsv10620 CNV loss 18304495
nsv10621 CNV loss 18304495
nsv1137512 CNV deletion 24896259
nsv290381 CNV deletion 16902084
nsv461857 CNV loss 19166990
nsv4626 CNV deletion 18451855
nsv509027 CNV insertion 20534489
nsv517941 CNV loss 19592680
nsv518484 CNV loss 19592680
nsv518587 CNV gain 19592680
nsv520498 CNV loss 19592680
nsv520838 CNV loss 19592680
nsv524982 CNV loss 19592680
nsv528891 CNV loss 19592680
nsv596310 CNV loss 21841781
nsv596311 CNV loss 21841781
nsv596312 CNV loss 21841781
nsv596313 CNV loss 21841781
nsv819047 CNV gain 19587683
nsv822869 CNV gain 20364138
nsv822870 CNV loss 20364138
nsv822871 CNV gain 20364138
nsv980499 CNV deletion 23825009

Variation tolerance for TENM3 Gene

Residual Variation Intolerance Score: 1.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TENM3 Gene

Human Gene Mutation Database (HGMD)
TENM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENM3 Gene

Disorders for TENM3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TENM3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microphthalmia, isolated, with coloboma 9
  • microphthalmia, isolated with coloboma 9
colobomatous microphthalmia
  • mac
lacrimal system cancer
  • lacrimal system neoplasm
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards
Search TENM3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEN3_HUMAN
  • Microphthalmia, isolated, with coloboma, 9 (MCOPCB9) [MIM:615145]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). {ECO:0000269 PubMed:22766609}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TENM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TENM3
genes like me logo Genes that share disorders with TENM3: view

No data available for Genatlas for TENM3 Gene

Publications for TENM3 Gene

  1. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PMID: 10625539) Ben-Zur T. … Wides R. (Dev. Biol. 2000) 2 3 4 64
  2. Homozygous null mutation in ODZ3 causes microphthalmia in humans. (PMID: 22766609) Aldahmesh M.A. … Alkuraya F.S. (Genet. Med. 2012) 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for TENM3 Gene

Sources for TENM3 Gene

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