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Aliases for TENM3 Gene

Aliases for TENM3 Gene

  • Teneurin Transmembrane Protein 3 2 3 4
  • ODZ3 3 4 6
  • TNM3 3 4 6
  • Protein Odd Oz/Ten-M Homolog 3 3 4
  • Tenascin-M3 3 4
  • KIAA1455 4 6
  • MCOPCB9 3 6
  • Ten-M3 3 4
  • Ten-3 3 4
  • Odz, Odd Oz/Ten-M Homolog 3 (Drosophila) 2
  • Odz, Odd Oz/Ten-M Homolog 3 3
  • Odd Oz/Ten-M Homolog 3 3
  • ODZ3-Like Protein 3
  • Teneurin-3 3

External Ids for TENM3 Gene

Previous HGNC Symbols for TENM3 Gene

  • ODZ3

Previous GeneCards Identifiers for TENM3 Gene

  • GC04P183067

Summaries for TENM3 Gene

GeneCards Summary for TENM3 Gene

TENM3 (Teneurin Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with TENM3 include microphthalmia, isolated, with coloboma 9 and colobomatous microphthalmia. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is WIF1.

UniProtKB/Swiss-Prot for TENM3 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM3 Gene

Genomics for TENM3 Gene

Genomic Location for TENM3 Gene

Start:
182,143,987 bp from pter
End:
182,803,024 bp from pter
Size:
659,038 bases
Orientation:
Plus strand

Genomic View for TENM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TENM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM3 Gene

No data available for Regulatory Elements for TENM3 Gene

Proteins for TENM3 Gene

  • Protein details for TENM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P273-TEN3_HUMAN
    Recommended name:
    Teneurin-3
    Protein Accession:
    Q9P273
    Secondary Accessions:
    • Q5XUL9
    • Q96SY2
    • Q9NV77
    • Q9NVW1
    • Q9NZJ2

    Protein attributes for TENM3 Gene

    Size:
    2699 amino acids
    Molecular mass:
    300950 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAA91633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91879.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55138.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENM3 Gene

Proteomics data for TENM3 Gene at MOPED

Post-translational modifications for TENM3 Gene

  • Glycosylation at Asn345, Asn380, Asn419, Asn670, Asn860, Asn883, Asn1202, Asn1527, Asn1544, Asn1640, Asn1677, Asn1735, Asn1820, Asn1921, Asn2124, Asn2264, and Asn2576
  • Modification sites at PhosphoSitePlus

Other Protein References for TENM3 Gene

No data available for DME Specific Peptides for TENM3 Gene

Domains for TENM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P273

UniProtKB/Swiss-Prot:

TEN3_HUMAN :
  • Q9P273
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins
  • Contains 8 EGF-like domains.
  • Contains 1 teneurin N-terminal domain.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
Similarity:
  • Contains 5 NHL repeats.
  • Contains 23 YD repeats.
genes like me logo Genes that share domains with TENM3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TENM3 Gene

Function for TENM3 Gene

Molecular function for TENM3 Gene

UniProtKB/Swiss-Prot Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).

Gene Ontology (GO) - Molecular Function for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0009055 electron carrier activity --
GO:0020037 heme binding --
GO:0042803 protein homodimerization activity ISS --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with TENM3: view

Phenotypes for TENM3 Gene

MGI mutant phenotypes for TENM3:
inferred from 1 alleles
GenomeRNAi human phenotypes for TENM3:
genes like me logo Genes that share phenotypes with TENM3: view

Animal Models for TENM3 Gene

MGI Knock Outs for TENM3:

miRNA for TENM3 Gene

miRTarBase miRNAs that target TENM3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TENM3 Gene

Localization for TENM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon.

Gene Ontology (GO) - Cellular Components for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with TENM3: view

No data available for Subcellular locations from COMPARTMENTS for TENM3 Gene

Pathways for TENM3 Gene

SuperPathways for TENM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007165 signal transduction IEA --
GO:0010976 positive regulation of neuron projection development ISS --
GO:0048593 camera-type eye morphogenesis IMP 22766609
GO:0097264 self proteolysis IEA --
genes like me logo Genes that share ontologies with TENM3: view

No data available for Pathways by source for TENM3 Gene

Transcripts for TENM3 Gene

Unigene Clusters for TENM3 Gene

Teneurin transmembrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TENM3 Gene

No ASD Table

Relevant External Links for TENM3 Gene

GeneLoc Exon Structure for
TENM3
ECgene alternative splicing isoforms for
TENM3

Expression for TENM3 Gene

mRNA expression in normal human tissues for TENM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TENM3 Gene

SOURCE GeneReport for Unigene cluster for TENM3 Gene Hs.130438

mRNA Expression by UniProt/SwissProt for TENM3 Gene

Q9P273-TEN3_HUMAN
Tissue specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.
genes like me logo Genes that share expressions with TENM3: view

No data available for mRNA differential expression in normal tissues for TENM3 Gene

Orthologs for TENM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TENM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODZ3 35
  • 99.31 (n)
  • 99.74 (a)
TENM3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODZ3 35
  • 90.52 (n)
  • 98.85 (a)
TENM3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM3 35
  • 92.44 (n)
  • 98.67 (a)
TENM3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm3 35
  • 89 (n)
  • 98.33 (a)
Tenm3 16
Tenm3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TENM3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TENM3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenm3 35
  • 89.07 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves ODZ3 35
  • 84.24 (n)
  • 96.48 (a)
ODZ3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TENM3 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8506 35
zebrafish
(Danio rerio)
Actinopterygii odz3 35
tenm3 35
  • 73.95 (n)
  • 83.61 (a)
tenm3 36
  • 82 (a)
OneToMany
TENM3 (2 of 2) 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000461 35
  • 46.45 (n)
  • 36.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ten-a 35
  • 46.21 (n)
  • 35.17 (a)
Species with no ortholog for TENM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM3 Gene

ENSEMBL:
Gene Tree for TENM3 (if available)
TreeFam:
Gene Tree for TENM3 (if available)

Paralogs for TENM3 Gene

Paralogs for TENM3 Gene

Selected SIMAP similar genes for TENM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TENM3: view

Variants for TENM3 Gene

Sequence variations from dbSNP and Humsavar for TENM3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11223 -- 182,799,697(-) TGCGC(A/G)CCGCC reference, synonymous-codon
rs13790 -- 182,800,596(+) CAGAG(A/G)AAAAA utr-variant-3-prime
rs719629 -- 182,480,436(+) TCTAA(C/T)GATGT intron-variant
rs719630 -- 182,480,640(+) TTTGG(A/G)ACTCT intron-variant
rs727695 -- 182,451,993(-) TACTA(C/T)AAAAT intron-variant

Relevant External Links for TENM3 Gene

HapMap Linkage Disequilibrium report
TENM3
Human Gene Mutation Database (HGMD)
TENM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TENM3 Gene

Disorders for TENM3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TENM3 Gene including...

Search for TENM3 Gene in MalaCards »

(1) OMIM Diseases for TENM3 Gene (610083)

UniProtKB/Swiss-Prot

TEN3_HUMAN
  • Microphthalmia, isolated, with coloboma, 9 (MCOPCB9) [MIM:615145]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). {ECO:0000269 PubMed:22766609}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with TENM3: view

Publications for TENM3 Gene

  1. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PMID: 10625539) Ben-Zur T. … Wides R. (Dev. Biol. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Homozygous null mutation in ODZ3 causes microphthalmia in humans. (PMID: 22766609) Aldahmesh M.A. … Alkuraya F.S. (Genet. Med. 2012) 3 4

Products for TENM3 Gene

Sources for TENM3 Gene

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