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Aliases for TENM3 Gene

Aliases for TENM3 Gene

  • Teneurin Transmembrane Protein 3 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 3 3 4
  • Tenascin-M3 3 4
  • Ten-M3 3 4
  • Ten-3 3 4
  • ODZ3 3 4
  • TNM3 3 4
  • Odz, Odd Oz/Ten-M Homolog 3 (Drosophila) 2
  • Testicular Tissue Protein Li 195 3
  • Odz, Odd Oz/Ten-M Homolog 3 3
  • ODZ3-Like Protein 3
  • KIAA1455 4
  • MCOPCB9 3

External Ids for TENM3 Gene

Previous HGNC Symbols for TENM3 Gene

  • ODZ3

Previous GeneCards Identifiers for TENM3 Gene

  • GC04P183067

Summaries for TENM3 Gene

Entrez Gene Summary for TENM3 Gene

  • This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]

GeneCards Summary for TENM3 Gene

TENM3 (Teneurin Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with TENM3 include Microphthalmia, Isolated, With Coloboma 9 and Colobomatous Microphthalmia. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is WIF1.

UniProtKB/Swiss-Prot for TENM3 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM3 Gene

Genomics for TENM3 Gene

Regulatory Elements for TENM3 Gene

Enhancers for TENM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TENM3 on UCSC Golden Path with GeneCards custom track

Promoters for TENM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TENM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TENM3 Gene

Chromosome:
4
Start:
182,143,987 bp from pter
End:
182,803,024 bp from pter
Size:
659,038 bases
Orientation:
Plus strand

Genomic View for TENM3 Gene

Genes around TENM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM3 Gene

Proteins for TENM3 Gene

  • Protein details for TENM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P273-TEN3_HUMAN
    Recommended name:
    Teneurin-3
    Protein Accession:
    Q9P273
    Secondary Accessions:
    • Q5XUL9
    • Q96SY2
    • Q9NV77
    • Q9NVW1
    • Q9NZJ2

    Protein attributes for TENM3 Gene

    Size:
    2699 amino acids
    Molecular mass:
    300950 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAA91633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91879.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55138.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENM3 Gene

Proteomics data for TENM3 Gene at MOPED

Post-translational modifications for TENM3 Gene

  • Glycosylation at Asn 345, Asn 380, Asn 419, Asn 670, Asn 860, Asn 883, Asn 1202, Asn 1527, Asn 1544, Asn 1640, Asn 1677, Asn 1735, Asn 1820, Asn 1921, Asn 2124, Asn 2264, and Asn 2576
  • Modification sites at PhosphoSitePlus

Other Protein References for TENM3 Gene

No data available for DME Specific Peptides for TENM3 Gene

Domains & Families for TENM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P273

UniProtKB/Swiss-Prot:

TEN3_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
  • Contains 5 NHL repeats.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
  • Contains 8 EGF-like domains.
  • Contains 1 teneurin N-terminal domain.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
Similarity:
  • Contains 5 NHL repeats.
  • Contains 23 YD repeats.
genes like me logo Genes that share domains with TENM3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TENM3 Gene

Function for TENM3 Gene

Molecular function for TENM3 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).
genes like me logo Genes that share phenotypes with TENM3: view

Human Phenotype Ontology for TENM3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TENM3 Gene

MGI Knock Outs for TENM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TENM3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TENM3 Gene

Localization for TENM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TENM3 Gene COMPARTMENTS Subcellular localization image for TENM3 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TENM3 Gene

Pathways & Interactions for TENM3 Gene

SuperPathways for TENM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010976 positive regulation of neuron projection development ISS --
genes like me logo Genes that share ontologies with TENM3: view

No data available for Pathways by source and SIGNOR curated interactions for TENM3 Gene

Drugs & Compounds for TENM3 Gene

No Compound Related Data Available

Transcripts for TENM3 Gene

Unigene Clusters for TENM3 Gene

Teneurin transmembrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TENM3 Gene

No ASD Table

Relevant External Links for TENM3 Gene

GeneLoc Exon Structure for
TENM3
ECgene alternative splicing isoforms for
TENM3

Expression for TENM3 Gene

mRNA expression in normal human tissues for TENM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TENM3 Gene

This gene is overexpressed in Breast (44.3), Fetal Brain (12.3), and Placenta (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TENM3 Gene



SOURCE GeneReport for Unigene cluster for TENM3 Gene Hs.130438

mRNA Expression by UniProt/SwissProt for TENM3 Gene

Q9P273-TEN3_HUMAN
Tissue specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.
genes like me logo Genes that share expression patterns with TENM3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TENM3 Gene

Orthologs for TENM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TENM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ODZ3 35
  • 90.52 (n)
  • 98.85 (a)
TENM3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM3 35
  • 92.44 (n)
  • 98.67 (a)
TENM3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm3 35
  • 89 (n)
  • 98.33 (a)
Tenm3 16
Tenm3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ODZ3 35
  • 99.31 (n)
  • 99.74 (a)
TENM3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenm3 35
  • 89.07 (n)
  • 98.18 (a)
oppossum
(Monodelphis domestica)
Mammalia TENM3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TENM3 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ODZ3 35
  • 84.24 (n)
  • 96.48 (a)
ODZ3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TENM3 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8506 35
zebrafish
(Danio rerio)
Actinopterygii odz3 35
tenm3 35
  • 73.95 (n)
  • 83.61 (a)
tenm3 36
  • 82 (a)
OneToMany
TENM3 (2 of 2) 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000461 35
  • 46.45 (n)
  • 36.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ten-a 35
  • 46.21 (n)
  • 35.17 (a)
Species with no ortholog for TENM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM3 Gene

ENSEMBL:
Gene Tree for TENM3 (if available)
TreeFam:
Gene Tree for TENM3 (if available)

Paralogs for TENM3 Gene

Paralogs for TENM3 Gene

(7) SIMAP similar genes for TENM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TENM3: view

Variants for TENM3 Gene

Sequence variations from dbSNP and Humsavar for TENM3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3749509 - 182,673,047(+) AGATT(C/G)CGGAG reference, missense
rs869239 -- 182,531,886(-) GAGCA(C/G)CTCAC intron-variant
rs869240 -- 182,531,106(+) GTGAA(A/G)AAGGC intron-variant
rs874152 -- 182,353,520(-) TATAT(C/T)AGGAA intron-variant
rs978520 -- 182,496,428(-) AATGC(C/T)GTTCC intron-variant

Variation tolerance for TENM3 Gene

Residual Variation Intolerance Score: 1.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TENM3 Gene

Human Gene Mutation Database (HGMD)
TENM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TENM3 Gene

Disorders for TENM3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TENM3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microphthalmia, isolated, with coloboma 9
  • microphthalmia, isolated with coloboma 9
colobomatous microphthalmia
  • mac
coloboma
  • coloboma of eye
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards
Search TENM3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEN3_HUMAN
  • Microphthalmia, isolated, with coloboma, 9 (MCOPCB9) [MIM:615145]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). {ECO:0000269 PubMed:22766609}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TENM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TENM3
genes like me logo Genes that share disorders with TENM3: view

No data available for Genatlas for TENM3 Gene

Publications for TENM3 Gene

  1. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PMID: 10625539) Ben-Zur T. … Wides R. (Dev. Biol. 2000) 2 3 4 67
  2. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. (PMID: 10331952) Ben-Zur T. … Wides R. (Genomics 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  5. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3

Products for TENM3 Gene

Sources for TENM3 Gene

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