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TENM2 Gene

protein-coding   GIFtS: 43
GCID: GC05P166711

Teneurin Transmembrane Protein 2

(Previous names: odz, odd Oz/ten-m homolog 2 (Drosophila))
(Previous symbol: ODZ2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Teneurin Transmembrane Protein 21 2 3     Odz, Odd Oz/Ten-M Homolog 22
ODZ21 2 3 5     ten-22
TNM22 3 5     tenascin-M22
Protein Odd Oz/Ten-M Homolog 22 3     Teneurin 22
KIAA11273 5     teneurin-22
Odz, Odd Oz/Ten-M Homolog 2 (Drosophila)1     Ten-23
TEN-M22     Ten-m23
Neurestin Alpha2     Tenascin-M23
Odd Oz/Ten-M Homolog 22     

External Ids:    HGNC: 299431   Entrez Gene: 574512   Ensembl: ENSG000001459347   OMIM: 6101195   UniProtKB: Q9NT683   

Export aliases for TENM2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


GeneCards Summary for TENM2 Gene:
TENM2 (teneurin transmembrane protein 2) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is WIF1.

UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68
Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous
system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic
cell-cell adhesion (By similarity). May function as a cellular signal transducer
Function: Isoform 2: Acts as a ligand of the LPHN1 receptor. Mediates axon guidance and heterophilic cell-cell
adhesion
Function: Ten-2 intracellular domain: Induces gene transcription inhibition (By similarity)

Gene Wiki entry for TENM2 (ODZ2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TENM2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TENM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TENM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q35

TENM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENM2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P166711:  view genomic region     (about GC identifiers)

Start:
166,711,804 bp from pter      End:
167,691,162 bp from pter
Size:
979,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68 (See protein sequence)
Recommended Name: Teneurin-2  
Size: 2774 amino acids; 307787 Da
Subunit: Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer
with TENM4 (By similarity). Isoform 2 (C-terminal globular domain) interacts with LPHN1 isoform 2
Secondary accessions: Q9ULU2
Alternative splicing: 2 isoforms:  Q9NT68-1   Q9NT68-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TENM2: NX_Q9NT68

Explore proteomics data for TENM2 at MOPED

Post-translational modifications: 

  • Ten-2, soluble form: Derives from the membrane form by proteolytic processing (By similarity)1
  • Ten-2 intracellular domain: Derives from the plasma membrane form by proteolytic cleavage and translocates to the
    nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and
    release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity)1
  • Glycosylation2 at Asn443, Asn482, Asn925, Asn948, Asn1267, Asn1616, Asn1712, Asn1749, Asn1773, Asn1807,
                                 Asn1892, Asn1993, Asn2197, Asn2337, Asn2648
  • Modification sites at PhosphoSitePlus

  • See TENM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001116151.1  
    ENSEMBL proteins: 
     ENSP00000429430   ENSP00000428964   ENSP00000427874   ENSP00000438635   ENSP00000384905  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    Selected InterPro protein domains (see all 9):
     IPR022385 Rhs_assc_core
     IPR000742 EG-like_dom
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013032 EGF-like_CS
     IPR008969 CarboxyPept-like_regulatory

    Graphical View of Domain Structure for InterPro Entry Q9NT68

    ProtoNet protein and cluster: Q9NT68

    UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68
    Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of
    intermolecular disulfide bonds
    Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins
    Similarity: Belongs to the tenascin family. Teneurin subfamily
    Similarity: Contains 8 EGF-like domains
    Similarity: Contains 5 NHL repeats
    Similarity: Contains 1 teneurin N-terminal domain
    Similarity: Contains 23 YD repeats


    Find genes that share domains with TENM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEN2_HUMAN, Q9NT68
    Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous
    system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic
    cell-cell adhesion (By similarity). May function as a cellular signal transducer
    Function: Isoform 2: Acts as a ligand of the LPHN1 receptor. Mediates axon guidance and heterophilic cell-cell
    adhesion
    Function: Ten-2 intracellular domain: Induces gene transcription inhibition (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity ISS--
    GO:0046982protein heterodimerization activity ISS--
         
    Find genes that share ontologies with TENM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TENM2:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tenm2):
     nervous system  vision/eye 

    Find genes that share phenotypes with TENM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tenm2tm1Cal for TENM2

       genOway: Develop your customized and physiologically relevant rodent model for TENM2

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    TEN2_HUMAN, Q9NT68: Cell membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (By
    similarity). Golgi apparatus (By similarity). Cell junction, synapse (By similarity). Cell projection, dendritic
    spine (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity).
    Cell junction, synapse, postsynaptic cell membrane; Single-pass membrane protein (By similarity). Cell junction,
    synapse, synaptosome (By similarity). Note=Colocalizes with LPHN1 across intercellular junctions (By similarity)
    TEN2_HUMAN, Q9NT68: Isoform 2: Cell membrane. Note=Colocalizes with LPHN1 across intercellular junctions
    TEN2_HUMAN, Q9NT68: Ten-2 intracellular domain: Nucleus, PML body (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005794Golgi apparatus ISS--
    GO:0005886plasma membrane ISS--
    GO:0005887integral component of plasma membrane IEA--

    Find genes that share ontologies with TENM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section






        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TENM2
    Interactions:

        Search GeneGlobe Interaction Network for TENM2

    1 Interacting protein for TENM2 (Q9NT683) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007157heterophilic cell-cell adhesion IDA--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance IDA--

    Find genes that share ontologies with TENM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TENM2 (TEN2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for TENM2 gene (6 alternative transcripts): 
    NM_001080428.2  NM_001122679.1  XM_005265950.1  XM_005265952.1  XM_006714897.1  XM_006714898.1  

    Unigene Cluster for TENM2:

    Teneurin transmembrane protein 2
    Hs.631957  [show with all ESTs]
    Unigene Representative Sequence: NM_001122679
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518659 ENST00000520393 ENST00000519204(uc003lzq.2 uc003lzr.4 uc003lzt.4)
    ENST00000520394 ENST00000517586 ENST00000518693 ENST00000522488 ENST00000521126
    ENST00000517941 ENST00000545108(uc021yhi.1) ENST00000403607(uc010jjd.3 uc010jje.3)

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    Additional mRNA sequence: 

    AB032953.2 AK056053.1 AK293262.1 AK302302.1 AL137500.1 BX648178.1 CR936703.1 HE578282.1 
    HE578283.1 HE610428.1 JN857072.1 JN857073.1 JN857074.1 JN857075.1 JN857076.1 

    6 DOTS entries:

    DT.434490  DT.101978854  DT.100659003  DT.95210375  DT.100023662  DT.120843028 

    9 AceView cDNA sequences:

    AL710285 BX953759 AK056053 AL710528 AL598057 BM017187 AL710634 BX648178 
    BF363040 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TENM2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -                                                                                                         
    SP2:                                                                                                                        


    ECgene alternative splicing isoforms for TENM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TENM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TENM2 Expression
    About this image


    TENM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
    TENM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TENM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631957

    UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68
    Tissue specificity: Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly
    expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal
    liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals.

    Orthologs for TENM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tenm21 , 5 odd Oz/ten-m homolog 2 (Drosophila)5
    teneurin transmembrane protein 21
    90.58(n)1
    98.63(a)1
      11 (21.96 cM)5
    239641  NM_011856.31  NP_035986.31 
     360066565 
    chicken
    (Gallus gallus)
    Aves ODZ21 odz, odd Oz/ten-m homolog 2 (Drosophila) 81.01(n)
    94.32(a)
      373854  NM_204097.2  NP_989428.2 
    lizard
    (Anolis carolinensis)
    Reptilia TENM26
    teneurin transmembrane protein 2
    94(a)
    1 ↔ 1
    1(111675566-112384664)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tenm21 teneurin transmembrane protein 2 76.8(n)
    89.98(a)
      100486468  XM_002934361.2  XP_002934407.2 
    zebrafish
    (Danio rerio)
    Actinopterygii odz21 odz, odd Oz/ten-m homolog 2 (Drosophila) 71.89(n)
    79.19(a)
      563197  XM_686559.6  XP_691651.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ten-m1 Tenascin major 48.19(n)
    37.09(a)
      40464  NM_079491.3  NP_524215.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ten-11 ten-1 41.22(n)
    30.67(a)
      175953  NM_001027552.3  NP_001022723.2 


    ENSEMBL Gene Tree for TENM2 (if available)
    TreeFam Gene Tree for TENM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for TENM2 gene
    WIF12  TENM12  TENM42  TENM32  VWDE2  
    10 SIMAP similar genes for TENM2 using alignment to 5 protein entries:     TEN2_HUMAN (see all proteins):
    ODZ2    TENM3    TENM4    TENM1    ODZ1    JAG1
    ITGB3    HMGA2/WIF1 fusion    ODZ4    ODZ3

    Find genes that share paralogs with TENM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for TENM2 (see all 19830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58730771,2
    C--162474073(+) CTATC-/GT/TG 
            
    TTAAT
    1 -- int10--------
    rs30565601,2
    C--162474075(+) TATCT-/GTTAATA 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs724529591,2
    C--162530214(+) TTAAG-/AAAAAAC 1 -- int10--------
    rs1897051551,2
    C--166709954(+) AGAGAC/TTCCAG 1 -- us2k10--------
    rs1471096261,2
    C--166709978(+) GCTAC-/TTGCTT 1 -- us2k10--------
    rs170682401,2
    C,F,H--166710003(+) GCAACT/GGAGGC 1 -- us2k111Minor allele frequency- G:0.07NA NS EA WA 916
    rs1823766581,2
    --166710111(+) ATGGCA/GGATCT 1 -- us2k10--------
    rs747550661,2
    C--166710196(+) GGTGCC/ACGCCA 1 -- us2k14Minor allele frequency- A:0.07NA WA EA 360
    rs1404336671,2
    --166710234(+) TTTTCA/TGTAGA 1 -- us2k10--------
    rs1465140301,2
    --166710420(+) TACACA/GTAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TENM2 (166711804 - 166961804 bp, first 250kb of TENM2)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TENM2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TENM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 610119    OMIM disorders: --


    Find genes that share disorders with TENM2           About GenesLikeMe


    Export disorders for TENM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for TENM2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TENM2)

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    2. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PubMed id 10625539)1, 3 Ben-Zur T.... Wides R. (Dev. Biol. 2000)
    3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    4. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. (PubMed id 12783990)1, 9 Bagutti C....Chiquet-Ehrismann R. (J. Cell. Sci. 2003)
    5. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. (PubMed id 23636237)1 Tanaka T....Nettleton J.A. (Am. J. Clin. Nutr. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PubMed id 22229870)1 Karns R....Deka R. (Ann. Hum. Genet. 2012)
    8. Genome-wide association study of periodontal pathogen colonization. (PubMed id 22699663)1 Divaris K....Offenbacher S. (J. Dent. Res. 2012)
    9. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    10. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high- affinity transsynaptic receptor pair with signaling capabilities. (PubMed id 21724987)2 Silva J.P.... Ushkaryov Y.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57451 HGNC: 29943 AceView: ODZ2 Ensembl:ENSG00000145934 euGenes: HUgn57451
    ECgene: TENM2 H-InvDB: TENM2

    (According to HUGE)
    About This Section
    HUGE: KIAA1127

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TENM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TENM2 gene:
    Search GeneIP for patents involving TENM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    CRISPR knockouts from OriGene)
    About This Section


     
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