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Aliases for TENM1 Gene

Aliases for TENM1 Gene

  • Teneurin Transmembrane Protein 1 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 1 3 4
  • TEN-M1 3 4
  • Ten-1 3 4
  • ODZ1 3 4
  • TNM1 3 4
  • Odz, Odd Oz/Ten-M Homolog 1 (Drosophila) 2
  • Odz (Odd Oz/Ten-M, Drosophila) Homolog 3 3
  • Odz, Odd Oz/Ten-M Homolog 1(Drosophila) 3
  • Odz, Odd Oz/Ten-M Homolog 1 3
  • Tenascin M1 3
  • Tenascin-M1 4
  • Tenascin M 2
  • Teneurin-1 3
  • ODZ3 3
  • TNM 3

External Ids for TENM1 Gene

Previous HGNC Symbols for TENM1 Gene

  • ODZ3
  • TNM
  • ODZ1

Previous GeneCards Identifiers for TENM1 Gene

  • GC0XM123511

Summaries for TENM1 Gene

Entrez Gene Summary for TENM1 Gene

  • The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for TENM1 Gene

TENM1 (Teneurin Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with TENM1 include Anal Margin Carcinoma and Lacrimal Gland Carcinoma. GO annotations related to this gene include protein homodimerization activity and heparin binding. An important paralog of this gene is TENM4.

UniProtKB/Swiss-Prot for TENM1 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).

  • Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).

  • Ten-1 intracellular domain: Induces gene transcription activation.

Gene Wiki entry for TENM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM1 Gene

Genomics for TENM1 Gene

Regulatory Elements for TENM1 Gene

Enhancers for TENM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF125394 0.7 Ensembl ENCODE 10.5 -190.8 -190760 2.2 ZNF316 EMSY TENM1 LOC392536 PIR59618
GH0XF125382 0.4 ENCODE 10.2 -178.0 -177971 0.5 POLR2A TENM1 LOC392536 PIR59618
GH0XF124554 0.4 ENCODE 7 +649.2 649188 1.6 ATF2 TENM1 RPS26P57 LOC105373331
GH0XF124593 0.5 ENCODE 4.8 +610.2 610151 1.2 ARID1B JUND ZBTB40 GABPA TENM1 RPS26P57 LOC105373331
GH0XF125203 0.7 ENCODE 0.8 -0.5 -527 3.5 CTCF RAD21 ZNF316 POLR2A PRDM10 E2F6 MAFK EZH2 ZNF263 RNF2 TENM1 TEX13C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TENM1 on UCSC Golden Path with GeneCards custom track

Promoters for TENM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001918790 -543 3000 CTCF RAD21 ZNF316 PRDM10 E2F6 MAFK EZH2 ZNF263 RNF2 MAFG

Genomic Location for TENM1 Gene

Chromosome:
X
Start:
124,375,903 bp from pter
End:
125,204,358 bp from pter
Size:
828,456 bases
Orientation:
Minus strand

Genomic View for TENM1 Gene

Genes around TENM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM1 Gene

Proteins for TENM1 Gene

  • Protein details for TENM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKZ4-TEN1_HUMAN
    Recommended name:
    Teneurin-1
    Protein Accession:
    Q9UKZ4
    Secondary Accessions:
    • B2RTR5
    • Q5JZ17

    Protein attributes for TENM1 Gene

    Size:
    2725 amino acids
    Molecular mass:
    305011 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer with either TENM2 or TENM3. May also form heterodimer with TENM4. Ten-1 ICD interacts with SORBS1 (via third SH3 domain). Interacts with MBD1 (By similarity).
    Miscellaneous:
    • Teneurin C-terminal-associated peptide: Binds to the plasma membrane and may be internalized by a receptor- and caveolae-mediated endocytosis manner to reach cytosolic compartments in a dynamin-dependent manner.

    Alternative splice isoforms for TENM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TENM1 Gene

Post-translational modifications for TENM1 Gene

  • Teneurin C-terminal-associated peptide: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).
  • Glycosylation at Asn 433, Asn 905, Asn 1084, Asn 1550, Asn 1567, Asn 1663, Asn 1699, Asn 1757, Asn 1781, Asn 1842, Asn 2145, Asn 2285, and Asn 2602
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TENM1 Gene

Domains & Families for TENM1 Gene

Suggested Antigen Peptide Sequences for TENM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKZ4

UniProtKB/Swiss-Prot:

TEN1_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
  • Contains 5 NHL repeats.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
  • Contains 8 EGF-like domains.
  • Contains 1 teneurin N-terminal domain.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
Similarity:
  • Contains 5 NHL repeats.
  • Contains 23 YD repeats.
genes like me logo Genes that share domains with TENM1: view

No data available for Gene Families for TENM1 Gene

Function for TENM1 Gene

Molecular function for TENM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
UniProtKB/Swiss-Prot Function:
Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
UniProtKB/Swiss-Prot Function:
Ten-1 intracellular domain: Induces gene transcription activation.

Gene Ontology (GO) - Molecular Function for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding TAS 10341219
GO:0042803 protein homodimerization activity IEA,ISS --
GO:0046982 protein heterodimerization activity IEA,ISS --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with TENM1: view

Phenotypes for TENM1 Gene

genes like me logo Genes that share phenotypes with TENM1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TENM1 Gene

Localization for TENM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM1 Gene

Cell membrane; Single-pass membrane protein.
Ten-1 intracellular domain: Nucleus. Nucleus speckle. Nucleus matrix. Cytoplasm, cytoskeleton.
Teneurin C-terminal-associated peptide: Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENM1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
extracellular 4
cytoskeleton 4
golgi apparatus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10341219
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with TENM1: view

Pathways & Interactions for TENM1 Gene

SuperPathways for TENM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter ISS --
GO:0006955 immune response TAS 10556288
genes like me logo Genes that share ontologies with TENM1: view

No data available for Pathways by source and SIGNOR curated interactions for TENM1 Gene

Transcripts for TENM1 Gene

Unigene Clusters for TENM1 Gene

Teneurin transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENM1 Gene

No ASD Table

Relevant External Links for TENM1 Gene

GeneLoc Exon Structure for
TENM1
ECgene alternative splicing isoforms for
TENM1

Expression for TENM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TENM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TENM1 Gene

This gene is overexpressed in Brain - Cerebellum (x9.9) and Brain - Cerebellar Hemisphere (x8.4).

Protein differential expression in normal tissues from HIPED for TENM1 Gene

This gene is overexpressed in Fetal gut (36.0) and Lung (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TENM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TENM1 Gene:

TENM1

SOURCE GeneReport for Unigene cluster for TENM1 Gene:

Hs.23796

mRNA Expression by UniProt/SwissProt for TENM1 Gene:

Q9UKZ4-TEN1_HUMAN
Tissue specificity: Expressed in fetal brain.
genes like me logo Genes that share expression patterns with TENM1: view

Primer Products

No data available for Protein tissue co-expression partners for TENM1 Gene

Orthologs for TENM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TENM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TENM1 35
  • 100 (a)
OneToOne
ODZ1 34
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia TENM1 35
  • 98 (a)
OneToOne
ODZ1 34
  • 92.93 (n)
dog
(Canis familiaris)
Mammalia TENM1 34 35
  • 94.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tenm1 34 16 35
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TENM1 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenm1 34
  • 90.04 (n)
chicken
(Gallus gallus)
Aves ODZ1 34 35
  • 80.15 (n)
lizard
(Anolis carolinensis)
Reptilia TENM1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tenm1 34
  • 75.25 (n)
zebrafish
(Danio rerio)
Actinopterygii tenm1 35
  • 67 (a)
OneToOne
LOC563094 34
  • 64.38 (n)
Species where no ortholog for TENM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM1 Gene

ENSEMBL:
Gene Tree for TENM1 (if available)
TreeFam:
Gene Tree for TENM1 (if available)

Paralogs for TENM1 Gene

Paralogs for TENM1 Gene

(4) SIMAP similar genes for TENM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TENM1: view

Variants for TENM1 Gene

Sequence variations from dbSNP and Humsavar for TENM1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs137882910 A breast cancer sample 124,497,065(+) CCTTA(C/T)AAAAT reference, missense
VAR_036596 A breast cancer sample
VAR_036598 A colorectal cancer sample
VAR_036599 A breast cancer sample
VAR_036600 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for TENM1 Gene

Variant ID Type Subtype PubMed ID
nsv7072 CNV insertion 18451855
nsv7071 CNV insertion 18451855
nsv524603 CNV gain 19592680
nsv523165 CNV gain 19592680
nsv478132 CNV novel sequence insertion 20440878
nsv1119360 CNV duplication 24896259
esv3577244 CNV gain 25503493
esv3574529 CNV loss 25503493
esv3574527 CNV loss 25503493
esv3574526 CNV loss 25503493
esv3559291 CNV deletion 23714750
esv3559289 CNV deletion 23714750
esv3396173 CNV insertion 20981092
esv3386317 CNV insertion 20981092
esv3306367 CNV mobile element insertion 20981092
esv2740449 CNV deletion 23290073
esv2662713 CNV deletion 23128226
esv22719 CNV loss 19812545
dgv2422e212 CNV loss 25503493

Variation tolerance for TENM1 Gene

Residual Variation Intolerance Score: 4.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.13; 69.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TENM1 Gene

Human Gene Mutation Database (HGMD)
TENM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENM1 Gene

Disorders for TENM1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TENM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anal margin carcinoma
  • carcinoma of anal margin
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
lacrimal system cancer
  • lacrimal system neoplasm
anal canal carcinoma
  • anal canal and perianal gland carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TENM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TENM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TENM1
genes like me logo Genes that share disorders with TENM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TENM1 Gene

Publications for TENM1 Gene

  1. Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain. (PMID: 10341219) Minet A.D. … Chiquet-Ehrismann R. (J. Cell Sci. 1999) 2 3 4 22 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. (PMID: 15777793) Nunes S.M. … Chiquet-Ehrismann R. (Exp. Cell Res. 2005) 3 22 64
  4. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. (PMID: 10331952) Ben-Zur T. … Wides R. (Genomics 1999) 2 3 64
  5. Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP). (PMID: 10556288) Brandau O. … Meindl A. (Hum. Mol. Genet. 1999) 3 4 64

Products for TENM1 Gene

Sources for TENM1 Gene

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