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Aliases for TENM1 Gene

Aliases for TENM1 Gene

  • Teneurin Transmembrane Protein 1 2 3 4
  • ODZ1 3 4 6
  • TNM1 3 4 6
  • Protein Odd Oz/Ten-M Homolog 1 3 4
  • Tenascin-M1 3 4
  • TEN-M1 3 4
  • Ten-1 3 4
  • Odz, Odd Oz/Ten-M Homolog 1 (Drosophila) 2
  • Odz (Odd Oz/Ten-M, Drosophila) Homolog 3 3
  • Odz, Odd Oz/Ten-M Homolog 1(Drosophila) 3
  • Odz, Odd Oz/Ten-M Homolog 1 3
  • Tenascin M1 3
  • Tenascin M 2
  • Teneurin 1 3
  • Teneurin-1 3
  • ODZ3 3
  • TNM 3

External Ids for TENM1 Gene

Previous Symbols for TENM1 Gene

  • ODZ3
  • TNM
  • ODZ1

Summaries for TENM1 Gene

Entrez Gene Summary for TENM1 Gene

  • The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for TENM1 Gene

TENM1 (Teneurin Transmembrane Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and heparin binding. An important paralog of this gene is WIF1.

UniProtKB/Swiss-Prot for TENM1 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).

  • Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).

  • Ten-1 intracellular domain: Induces gene transcription activation.

Gene Wiki entry for TENM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM1 Gene

Genomics for TENM1 Gene

Genomic Location for TENM1 Gene

Start:
124,375,903 bp from pter
End:
124,963,817 bp from pter
Size:
587,915 bases
Orientation:
Minus strand

Genomic View for TENM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TENM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM1 Gene

No data available for Regulatory Elements for TENM1 Gene

Proteins for TENM1 Gene

  • Protein details for TENM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKZ4-TEN1_HUMAN
    Recommended name:
    Teneurin-1
    Protein Accession:
    Q9UKZ4
    Secondary Accessions:
    • B2RTR5
    • Q5JZ17

    Protein attributes for TENM1 Gene

    Size:
    2725 amino acids
    Molecular mass:
    305011 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer with either TENM2 or TENM3. May also form heterodimer with TENM4. Ten-1 ICD interacts with SORBS1 (via third SH3 domain). Interacts with MBD1 (By similarity).
    Miscellaneous:
    • Teneurin C-terminal-associated peptide: Binds to the plasma membrane and may be internalized by a receptor- and caveolae-mediated endocytosis manner to reach cytosolic compartments in a dynamin-dependent manner.

    Alternative splice isoforms for TENM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TENM1 Gene

Proteomics data for TENM1 Gene at MOPED

Post-translational modifications for TENM1 Gene

  • Teneurin C-terminal-associated peptide: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn433, Asn905, Asn1084, Asn1550, Asn1567, Asn1663, Asn1699, Asn1757, Asn1781, Asn1842, Asn2145, Asn2285, and Asn2602

Other Protein References for TENM1 Gene

No data available for DME Specific Peptides for TENM1 Gene

Domains for TENM1 Gene

Protein Domains for TENM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKZ4

UniProtKB/Swiss-Prot:

TEN1_HUMAN
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds:
    • Q9UKZ4
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins:
    • Q9UKZ4
  • Contains 8 EGF-like domains.:
    • Q9UKZ4
  • Contains 1 teneurin N-terminal domain.:
    • Q9UKZ4
Family:
  • Belongs to the tenascin family. Teneurin subfamily.:
    • Q9UKZ4
Similarity:
  • Contains 5 NHL repeats.:
    • Q9UKZ4
  • Contains 23 YD repeats.:
    • Q9UKZ4
genes like me logo Genes that share domains with TENM1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TENM1 Gene

Function for TENM1 Gene

Molecular function for TENM1 Gene

UniProtKB/Swiss-Prot Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
UniProtKB/Swiss-Prot Function: Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
UniProtKB/Swiss-Prot Function: Ten-1 intracellular domain: Induces gene transcription activation.

Gene Ontology (GO) - Molecular Function for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008201 heparin binding TAS 10341219
GO:0042803 protein homodimerization activity ISS --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with TENM1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TENM1 Gene

Localization for TENM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM1 Gene

Cell membrane; Single-pass membrane protein.
Ten-1 intracellular domain: Nucleus. Nucleus speckle. Nucleus matrix. Cytoplasm, cytoskeleton.
Teneurin C-terminal-associated peptide: Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10341219
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with TENM1: view

No data available for Subcellular locations from COMPARTMENTS for TENM1 Gene

Pathways for TENM1 Gene

SuperPathways for TENM1 Gene

No Data Available

Interacting Proteins for TENM1 Gene

Gene Ontology (GO) - Biological Process for TENM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter ISS --
GO:0006950 response to stress --
GO:0006955 immune response TAS 10556288
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TENM1: view

No data available for Pathways by source for TENM1 Gene

Transcripts for TENM1 Gene

Unigene Clusters for TENM1 Gene

Teneurin transmembrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TENM1 Gene

No ASD Table

Relevant External Links for TENM1 Gene

GeneLoc Exon Structure for
TENM1
ECgene alternative splicing isoforms for
TENM1

Expression for TENM1 Gene

mRNA expression in normal human tissues for TENM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TENM1 Gene

This gene is overexpressed in Brain - Cerebellum (9.9) and Brain - Cerebellar Hemisphere (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TENM1 Gene

SOURCE GeneReport for Unigene cluster for TENM1 Gene Hs.23796

mRNA Expression by UniProt/SwissProt for TENM1 Gene

Q9UKZ4-TEN1_HUMAN
Tissue specificity: Expressed in fetal brain.
genes like me logo Genes that share expressions with TENM1: view

Orthologs for TENM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TENM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODZ1 35
  • 98.6 (n)
  • 98.38 (a)
TENM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODZ1 35
  • 92.93 (n)
  • 97.97 (a)
TENM1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM1 35
  • 94.01 (n)
  • 98.43 (a)
TENM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm1 35
  • 91.33 (n)
  • 97 (a)
Tenm1 16
Tenm1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TENM1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tenm1 35
  • 90.04 (n)
  • 95.46 (a)
chicken
(Gallus gallus)
Aves ODZ1 35
  • 80.15 (n)
  • 89.91 (a)
ODZ1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TENM1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tenm1 35
  • 75.25 (n)
  • 83 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563094 35
  • 64.38 (n)
  • 66.49 (a)
tenm1 36
  • 67 (a)
OneToOne
Species with no ortholog for TENM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM1 Gene

ENSEMBL:
Gene Tree for TENM1 (if available)
TreeFam:
Gene Tree for TENM1 (if available)

Paralogs for TENM1 Gene

Paralogs for TENM1 Gene

Selected SIMAP similar genes for TENM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TENM1: view

Variants for TENM1 Gene

Sequence variations from dbSNP and Humsavar for TENM1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs586 -- 124,502,923(-) CTAAG(A/G)GATCC intron-variant
rs2186 -- 124,547,449(+) GAATG(C/T)GATGA intron-variant
rs15910 -- 124,377,345(-) TTATC(G/T)AGAAG utr-variant-3-prime
rs16298 -- 124,686,197(-) gctat(-/T)atcac intron-variant
rs16299 -- 124,686,117(-) atgat(-/T)aggcc intron-variant

Relevant External Links for TENM1 Gene

HapMap Linkage Disequilibrium report
TENM1
Human Gene Mutation Database (HGMD)
TENM1
Locus Specific Mutation Databases (LSDB)
TENM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TENM1 Gene

Disorders for TENM1 Gene

No disorders were found for TENM1 Gene.

No data available for UniProtKB/Swiss-Prot for TENM1 Gene

Publications for TENM1 Gene

  1. Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain. (PMID: 10341219) Minet A.D. … Chiquet-Ehrismann R. (J. Cell Sci. 1999) 2 3 4 23
  2. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. (PMID: 15777793) Nunes S.M. … Chiquet-Ehrismann R. (Exp. Cell Res. 2005) 3 23
  3. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. (PMID: 10331952) Ben-Zur T. … Wides R. (Genomics 1999) 2 3
  4. Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP). (PMID: 10556288) Brandau O. … Meindl A. (Hum. Mol. Genet. 1999) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for TENM1 Gene

Sources for TENM1 Gene

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