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TENC1 Gene

protein-coding   GIFtS: 55
GCID: GC12P053440

Tensin Like C1 Domain Containing Phosphatase (Tensin 2)

(Previous name: tensin like C1 domain-containing phosphatase)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tensin Like C1 Domain Containing Phosphatase (Tensin 2)1 2     C1TEN2 5
Tensin Like C1 Domain-Containing Phosphatase1 2     KIAA10753 5
Tensin 21 2     tensin-22
C1-TEN2 3     Tensin-Like C1 Domain-Containing Phosphatase2
TNS22 3     EC 3.1.3.-3
C1 Domain-Containing Phosphatase And Tensin Homolog2 3     Tensin-23

External Ids:    HGNC: 197371   Entrez Gene: 233712   Ensembl: ENSG000001110777   OMIM: 6077175   UniProtKB: Q63HR23   

Export aliases for TENC1 gene to outside databases

Previous GC identifers: GC12P053354 GC12P053157 GC12P051727 GC12P050483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TENC1 Gene:
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to
actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration.
Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have
been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for TENC1 Gene:
TENC1 (tensin like C1 domain containing phosphatase (tensin 2)) is a protein-coding gene. Diseases associated with TENC1 include kidney cancer, and ataxia. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is DNAJC6.

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
Lowers AKT1 kinase activity and interferes with AKT1 signaling

Gene Wiki entry for TENC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TENC1 gene promoter:
         CHOP-10   Ik-2   C/EBPalpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTENC1 promoter sequence
   Search Chromatin IP Primers for TENC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TENC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

TENC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053440:  view genomic region     (about GC identifiers)

Start:
53,440,753 bp from pter      End:
53,458,163 bp from pter
Size:
17,411 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2 (See protein sequence)
Recommended Name: Tensin-like C1 domain-containing phosphatase  
Size: 1409 amino acids; 152580 Da
Subunit: Interacts with AXL
Sequence caution: Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI31504.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA83027.2; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAH56176.1; Type=Miscellaneous discrepancy;
Note=Intron retention;
5 PDB 3D structures from and Proteopedia for TENC1:
2DKQ (3D)        2KNO (3D)        2L6K (3D)        2LOZ (3D)        3HQC (3D)    
Secondary accessions: A2VDF2 A2VDF3 A2VDI8 A5PKY4 Q2NL80 Q76MW6 Q7Z5T9 Q8NFF9 Q8NFG0 Q96P25
Q9NT29 Q9UPS7
Alternative splicing: 5 isoforms:  Q63HR2-1   Q63HR2-2   Q63HR2-4   Q63HR2-5   Q63HR2-6   

Explore the universe of human proteins at neXtProt for TENC1: NX_Q63HR2

Explore proteomics data for TENC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TENC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_056134.2  NP_736610.2  NP_938072.1  

    ENSEMBL proteins: 
     ENSP00000369232   ENSP00000319756   ENSP00000319684   ENSP00000449363   ENSP00000447021  
     ENSP00000449361   ENSP00000473388   ENSP00000449165   ENSP00000393362  

    TENC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TENC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for TENC1  (tensin 2)
    OriGene Antibodies for TENC1
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    Novus Biologicals TENC1 Antibodies
    Abcam antibodies for TENC1
    Browse Antibodies at Cloud-Clone Corp.
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    TENC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TENC1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    Selected InterPro protein domains (see all 8):
     IPR014019 Phosphatase_tensin-typ
     IPR013625 PTB
     IPR006020 PTB/PI_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q63HR2

    ProtoNet protein and cluster: Q63HR2

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    TENC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENC1_HUMAN, Q63HR2
    Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
    Lowers AKT1 kinase activity and interferes with AKT1 signaling

         Enzyme Number (IUBMB): EC 3.1.3.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding IPI16273093
    GO:0046872metal ion binding IEA--
         
    TENC1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tenc1):
     adipose tissue  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system 

    TENC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TENC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TENC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TENC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TENC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TENC1:
    hsa-mir-335-5p (MIRT018978), hsa-mir-26b-5p (MIRT030195)

    Block miRNA regulation of human, mouse, rat TENC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TENC1 (see all 12):
    hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTENC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TENC1
    Predesigned siRNA for gene silencing in human, mouse, rat TENC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TENC1

    Clone
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    OriGene clones in human, mouse for TENC1 (see all 17)
    OriGene ORF clones in mouse, rat for TENC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TENC1 (NM_198316)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TENC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TENC1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TENC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TENC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TENC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TENC1_HUMAN, Q63HR2: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Detected at the end of actin stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IDA16951145

    TENC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TENC1 About    
    See pathways by source

    SuperPathContained pathways About
    1PI3K / Akt Signaling
    PI3K / Akt Signaling
    2Cytoskeletal Signaling
    Cytoskeletal Signaling
    3Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for TENC1
        Cytoskeletal Signaling
    PI3K / Akt Signaling
    Adhesion



    TENC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TENC1: 
              Protein Phosphatases in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TENC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TENC1 (Q63HR21, 2, 3 ENSP000003197564) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-949753,EBI-641062 MINT-74780 MINT-74778 MINT-74781 MINT-74779 I2D: score=2 STRING: ENSP00000269571
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2870938 I2D: score=3 STRING: ENSP00000344782
    ITGB7P260102, 3, ENSP000002670824MINT-61567 I2D: score=3 STRING: ENSP00000267082
    ITGB5P180842, 3, ENSP000002961814MINT-61566 I2D: score=2 STRING: ENSP00000296181
    ITGB3P051062, 3MINT-61480 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0008285negative regulation of cell proliferation IMP16951145
    GO:0014850response to muscle activity IEA--
    GO:0019725cellular homeostasis IEA--
    GO:0032963collagen metabolic process IEA--

    TENC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TENC1

    Selected HMDB Compounds for TENC1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TENC1 gene (3 alternative transcripts): 
    NM_015319.2  NM_170754.2  NM_198316.1  

    Unigene Cluster for TENC1:

    Tensin like C1 domain containing phosphatase (tensin 2)
    Hs.6147  [show with all ESTs]
    Unigene Representative Sequence: BC150259
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000379902(uc001sbl.3) ENST00000314276(uc001sbn.3) ENST00000549498(uc001sbm.3)
    ENST00000551302 ENST00000314250(uc001sbp.3) ENST00000552403 ENST00000549311(uc001sbo.1 uc001sbr.3)
    ENST00000546602(uc001sbq.3) ENST00000552570(uc009zmr.3) ENST00000549700
    ENST00000551693 ENST00000549789 ENST00000547223 ENST00000602335 ENST00000546759
    ENST00000551583 ENST00000546772 ENST00000550660
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TENC1 (see all 12):
    hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTENC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TENC1
    Clone
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    OriGene clones in human, mouse for TENC1 (see all 17)
    OriGene ORF clones in mouse, rat for TENC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TENC1 (NM_198316)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TENC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TENC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TENC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TENC1
      QuantiTect SYBR Green Assays in human, mouse, rat TENC1
      QuantiFast Probe-based Assays in human, mouse, rat TENC1

    Additional mRNA sequence: 

    AB028998.2 AF417490.1 AF518728.1 AF518729.1 AK131320.1 AK172747.1 AL137564.1 BC054099.1 
    BC110854.1 BC129828.1 BC129829.1 BC131503.1 BC142668.1 BC142712.1 BC150259.1 BX647126.1 
    CR936725.1 

    20 DOTS entries:

    DT.100648283  DT.95295531  DT.95151181  DT.449115  DT.121118050  DT.40269374  DT.100651420  DT.101982588 
    DT.100724559  DT.91689288  DT.100648284  DT.92441328  DT.95151174  DT.97784943  DT.101961374  DT.121118477 
    DT.95101213  DT.121117936  DT.121118973  DT.92036991 

    Selected AceView cDNA sequences (see all 292):

    AF417490 AF518729 BM693074 BM015525 CD172215 BX647126 AI040475 BQ005265 
    CR614736 BQ681229 BQ774302 AW169055 CO247269 AW189936 AW292399 BU180302 
    BU616495 AK131320 BU736594 BE502630 BU521796 NM_198316 BE326739 BU074888 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TENC1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:        -     -     -     -     -     -           -                 -                 -                             -                                   -   
    SP2:                          -     -     -           -                 -                 -                             -                                   -   
    SP3:                                                  -                 -                 -                             -                                   -   
    SP4:                                                  -                 -                 -                             -                                   -   
    SP5:                                                                                                                                                        -   

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
    SP1:              -                                                     -     -                                   -                                 
    SP2:              -                                                     -     -                                   -                                 
    SP3:              -                                                     -     -                                   -                                 
    SP4:              -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:              -                       -                             -     -                                   -                                 


    ECgene alternative splicing isoforms for TENC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TENC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGGGGAA
    TENC1 Expression
    About this image


    TENC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)
             Rib
     
     Limb (Muscoskeletal System)
             Autopod
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    TENC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TENC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6147

    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and
    small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TENC1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TENC1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tenc11 , 5 tensin like C1 domain-containing phosphatase1, 5 86.28(n)1
    90.64(a)1
      15 (57.29 cM)5
    2090391  NM_153533.21  NP_705761.21 
     1021029885 
    lizard
    (Anolis carolinensis)
    Reptilia TENC16
    tensin like C1 domain containing phosphatase (tens...
    50(a)
    1 ↔ 1
    GL343212.1(2853076-2901698)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tenc11 tensin like C1 domain containing phosphatase (tensin more 60.15(n)
    59.45(a)
      100486792  XM_002936643.2  XP_002936689.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tenc1a1 tensin like C1 domain containing phosphatase a 60.96(n)
    60.74(a)
      799109  XM_001921008.2  XP_001921043.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    29(a)
    1 → many
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Protein TAG-163, isoform a (tag-163) mRNA, complet...
    24(a)
    1 → many
    I(5583405-5597332) WBGene00006508


    ENSEMBL Gene Tree for TENC1 (if available)
    TreeFam Gene Tree for TENC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TENC1 gene
    DNAJC62  PTEN2  TNS12  TPTE2  GAK2  TPTE22  TNS42  TNS32  
    4 SIMAP similar genes for TENC1 using alignment to 6 protein entries:     TENC1_HUMAN (see all proteins):
    DKFZp434G162    PTEN    TNS4    TNS3

    TENC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TENC1 (see all 342)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107835591,2
    C,F,A,H--53274744(+) TCTTTC/TTGCCT 1 -- us2k122Minor allele frequency- T:0.35NS EA NA CSA WA 2350
    rs748913011,2
    C,F--53274757(+) GTCCCG/TCCGGG 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs763594581,2
    C,F--53274768(+) TCAGGC/TTCTCC 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs2002923901,2
    C--53450424(+) GGACA-/CAAT  
            
    AATCA
    3 -- int10--------
    rs1384644991,2
    --53450458(+) CTTCAG/TTATGG 3 -- int10--------
    rs1426511171,2
    --53450584(+) TTTTAC/TAGATG 3 -- int10--------
    rs1502592851,2
    --53450592(+) ATGAAA/GAAACT 3 -- int10--------
    rs21397741,2
    C,F--53450625(-) tgttgG/Agcctc 3 -- int13Minor allele frequency- A:0.01NA 142
    rs1163764391,2
    F--53450678(+) CACTAC/TTCTGG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs2010492501,2
    --53450800(+) AGGGCA/GGACCA 6 A syn10--------

    HapMap Linkage Disequilibrium report for TENC1 (53440753 - 53458163 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TENC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899098CNV Loss21882294
    esv28917CNV Loss19812545
    nsv470294CNV Loss18288195
    nsv899099CNV Loss21882294
    nsv517066CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TENC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TENC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607717    OMIM disorders: --

    5 diseases for TENC1:    
    About MalaCards
    kidney cancer    ataxia    hepatocellular carcinoma    prostate cancer
    prostatitis


    TENC1 for disorders           About GeneDecksing


    Export disorders for TENC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TENC1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with TENC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PubMed id 15817639)1, 2 Hafizi S.... Dahlbaeck B. (FASEB J. 2005)
    2. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PubMed id 11792844)1, 2 Chen H.... Lo S.H. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (Biochem. Biophys. Res. Commun. 2002)
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    5. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PubMed id 20069572)1, 9 Clark K....Critchley D.R. (J. Cell. Biochem. 2010)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Interaction of DISC1 with the PTB domain of Tensin2. (PubMed id 23233134)1 Goudarzi S....Hafizi S. (Cell. Mol. Life Sci. 2013)
    8. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. (PubMed id 22019427)1 Moon K.D....Geahlen R.L. (Biochim. Biophys. Acta 2012)
    9. Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. (PubMed id 22645138)1 Chen L....Zhu G. (J. Biol. Chem. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23371 HGNC: 19737 AceView: TENC1 Ensembl:ENSG00000111077 euGenes: HUgn23371
    ECgene: TENC1 H-InvDB: TENC1

    (According to HUGE)
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    HUGE: KIAA1075

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TENC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TENC1 gene:
    Search GeneIP for patents involving TENC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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