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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TENC1 Gene

protein-coding GIFtS: 56
GCID: GC12P053440

tensin like C1 domain containing phosphatase (tensin 2)

(Previous name: tensin like C1 domain-containing phosphatase )

Explore 5 diseases affiliated with
TENC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tensin Like C1 Domain Containing Phosphatase (Tensin 2)¹ ²		C1TEN² ⁵
C1-TEN¹ ² ³		Tensin 2²
TNS2¹ ² ³		Tensin-2³
KIAA1075¹ ³ ⁵		Tensin-Like C1 Domain-Containing Phosphatase²
Tensin Like C1 Domain-Containing Phosphatase¹ ²		EC 3.1.3.-³
C1 Domain-Containing Phosphatase And Tensin Homolog² ³		Tensin-2³

External Ids:	HGNC: 19737¹	Entrez Gene: 23371²	Ensembl: ENSG00000111077⁷	OMIM: 607717⁵	UniProtKB: Q63HR2³

Export aliases for TENC1 gene to outside databases

Previous GC identifers: GC12P053354 GC12P053157 GC12P051727 GC12P050483

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TENC1:

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin

filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative

splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2

Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.

Lowers AKT1 kinase activity and interferes with AKT1 signaling

Gene Wiki entry for TENC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TENC1 gene promoter:
CHOP-10 Ik-2 C/EBPalpha E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TENC1 promoter sequence

Search SABiosciences Chromatin IP Primers for TENC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TENC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13

TENC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENC1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P053440: view genomic region (about GC identifiers)

Start:	53,440,753 bp from pter	End:	53,458,163 bp from pter
Size:	17,411 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2 (See protein sequence)

Recommended Name: Tensin-like C1 domain-containing phosphatase

Size: 1409 amino acids; 152580 Da

Subunit: Interacts with AXL

Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Note=Detected at the end of actin stress fibers

Sequence caution: Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI31504.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA83027.2; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention;

5 PDB 3D structures from and Proteopedia for TENC1:

2DKQ (3D)

2KNO (3D)

2L6K (3D)

2LOZ (3D)

3HQC (3D)

Secondary accessions: A2VDF2 A2VDF3 A2VDI8 A5PKY4 Q2NL80 Q76MW6 Q7Z5T9 Q8NFF9 Q8NFG0 Q96P25 Q9NT29

Q9UPS7

Alternative splicing: 5 isoforms: Q63HR2-1 Q63HR2-2 Q63HR2-4 Q63HR2-5 Q63HR2-6

Explore the universe of human proteins at neXtProt for TENC1: NX_Q63HR2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q63HR2

TENC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_056134.2 NP_736610.2 NP_938072.1

ENSEMBL proteins:

ENSP00000369232 ENSP00000319756 ENSP00000319684 ENSP00000446586 ENSP00000449363

ENSP00000447021 ENSP00000449361 ENSP00000449165 ENSP00000393362

Human Recombinant Protein Products for TENC1:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TENC1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IDA	16951145

TENC1 for ontologies About GeneDecksing

TENC1 Antibody Products:

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	Uscn ELISAs and CLIAs for TENC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TENC1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR014019 Phosphatase_tensin-typ

IPR013625 PTB

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR006020 PTyr_interaction_dom

IPR002219 Prot_Kinase_C-like_PE/DAG-bd

Graphical View of Domain Structure for InterPro Entry Q63HR2

ProtoNet protein and cluster: Q63HR2

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB013625 Tensin phosphotyrosine-binding domain

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2

Similarity: Contains 1 C2 tensin-type domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 phosphatase tensin-type domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TENC1_HUMAN, Q63HR2

Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.

Lowers AKT1 kinase activity and interferes with AKT1 signaling

Enzyme Number (IUBMB): EC 3.1.3.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	IEA	--
GO:0005515	protein binding	IPI	17190795
GO:0046872	metal ion binding	IEA	--

TENC1 for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tenc1):

adipose tissue	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	renal/urinary system	reproductive system

TENC1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TENC1

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		hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: TENC1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TENC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Adhesion

Adhesion

1.00

PI3K / Akt Signaling

PI3K / Akt Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Cell Signaling Technology (CST) Pathways for TENC1

	Cytoskeletal Signaling
	PI3K / Akt Signaling
	Adhesion

TENC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TENC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/14 Interacting proteins for TENC1 (Q63HR2^{2, 3} ENSP00000319756⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74780 MINT-74778 MINT-74781 MINT-74779 I2D: score=2 STRING: ENSP00000269571
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2870938 I2D: score=3 STRING: ENSP00000344782
ITGB7	P26010²^,³, ENSP00000267082⁴	MINT-61567 I2D: score=3 STRING: ENSP00000267082
ITGB5	P18084²^,³, ENSP00000296181⁴	MINT-61566 I2D: score=2 STRING: ENSP00000296181
ERBB3	P21860²^,³, ENSP00000267101⁴	MINT-74782 MINT-74783 MINT-74784 I2D: score=2 STRING: ENSP00000267101

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEA	--
GO:0008285	negative regulation of cell proliferation	IMP	16951145
GO:0014850	response to muscle activity	IEA	--
GO:0019725	cellular homeostasis	IEA	--
GO:0032963	collagen metabolic process	IEA	--

TENC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TENC1

10/843 HMDB Compounds for TENC1 (see all 843) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--
DG(14:0/18:3(6Z,9Z,12Z)/0:0)	Diacylglycerol(14:0/18:3n6) (see all 16)	--	--

Search CenterWatch for drugs/clinical trials and news about TENC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TENC1 gene (3 alternative transcripts):

NM_015319.2 NM_170754.2 NM_198316.1

Unigene Cluster for TENC1:

Tensin like C1 domain containing phosphatase (tensin 2)

Hs.6147 [show with all ESTs]

Unigene Representative Sequence: BC150259

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000379902(uc001sbl.3) ENST00000314276(uc001sbn.3) ENST00000549498(uc001sbm.3)

ENST00000551302 ENST00000314250(uc001sbp.3) ENST00000552403 ENST00000549311(uc001sbo.1 uc001sbr.3)

ENST00000546602(uc001sbq.3) ENST00000552570(uc009zmr.3) ENST00000549700

ENST00000551693 ENST00000549789 ENST00000547223 ENST00000546759 ENST00000551583

ENST00000546772 ENST00000550660 ENST00000552168

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		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TENC1 (see all 12):
		hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: TENC1 3' UTR sequence

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Additional cDNA sequence:

AB028998.2 AF417490.1 AF518728.1 AF518729.1 AK131320.1 AK172747.1 AL137564.1 BC054099.1

BC110854.1 BC129828.1 BC129829.1 BC131503.1 BC142668.1 BC142712.1 BC150259.1 BX647126.1

CR936725.1

20 DOTS entries:

DT.100648283 DT.95295531 DT.95151181 DT.449115 DT.121118050 DT.40269374 DT.100651420 DT.101982588

DT.100724559 DT.91689288 DT.100648284 DT.92441328 DT.95151174 DT.97784943 DT.101961374 DT.121118477

DT.95101213 DT.121117936 DT.121118973 DT.92036991

24/292 AceView cDNA sequences (see all 292):

NM_015319 BU074600 AI767231 BM704273 AI206151 H97675 CO247269 CR607439

BU736594 D31134 CA434026 BE502630 BQ681229 AI040475 CD172215 AW590137

AW169055 BF941721 CN479477 BM669797 BX647126 AW292399 NM_198316 AA700778

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TENC1 (see all 14) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18a	·
SP1:			-		-		-		-		-		-				-						-						-										-												-
SP2:									-		-		-				-						-						-										-												-
SP3:																	-						-						-										-												-
SP4:																	-						-						-										-												-
SP5:																																																			-

ExUns:	18b	^	19a	·	19b	^	20a	·	20b	·	20c	·	20d	^	21	^	22	^	23	^	24	^	25a	·	25b	·	25c	·	25d	^	26	^	27	^	28a	·	28b	^	29a	·	29b	·	29c	^	30	^	31
SP1:					-																		-		-												-
SP2:					-																		-		-												-
SP3:					-																		-		-												-
SP4:					-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:					-								-										-		-												-

ECgene alternative splicing isoforms for TENC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TENC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAGGGGAA

About this image

TENC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Bone

Cartilage

Cartilage

Rostral Chondrocranium

Cartilage

Rostral Synchondroses

Cartilage

Cartilage

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TENC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TENC1

SOURCE GeneReport for Unigene cluster: Hs.6147

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2

Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small

intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including TENC1:

Protein Phosphatases in human mouse rat

Focal Adhesions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TENC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TENC1 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TENC1⁶	--	62(a)	1 ↔ 1	GL343212.1(2853076-2901522)
zebrafish (Danio rerio)	Actinopterygii	LOC799109¹	tensin-like C1 domain-containing phosphatase-like	56.3(n) 54.6(a)		799109 XM_001921008.1 XP_001921043.1
honey bee (Apis mellifera)	Insecta	--	--	30(a)	1 → many	Group13.7(501651-513471)
worm (Caenorhabditis elegans)	Secernentea	tag-83⁶	Putative protein phosphatase tag-83	26(a)	1 → many	I(5600672-5603484)
thale cress (Arabidopsis thaliana)	eudicotyledons	PEN3⁶ PEN2⁶	phosphatidylinositol-3,4,5-trisphosphate 3-phospha... phosphatidylinositol-3,4,5-trisphosphate 3-phospha...	14(a) 14(a)	possible ortholog possible ortholog	3(18580609-18584535) 3(6731376-6735623)
rice (Oryza sativa)	Liliopsida	--	PTEN, putative, expressed	12(a)	possible ortholog	12(12318999-12327551)

ENSEMBL Gene Tree for TENC1 (if available)
TreeFam Gene Tree for TENC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TENC1 gene

TNS1² DNAJC6² PTEN² TPTE² TNS4² TNS3² GAK² TPTE2²

5 SIMAP similar genes for TENC1 using alignment to 6 protein entries: TENC1_HUMAN (see all proteins):

DKFZp434G162 PTEN TNS3 TNS4 TNS1

TENC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74891301^1,2	F	--	50483826(+)	`GTCCCG/TCCGGG`	1	--	us2k¹		1		WA	118
rs76359458^1,2	C,F	--	50483837(+)	`TCAGGC/TTCTCC`	1	--	us2k¹		1		WA	118
rs146666753^1,2		--	53438949(+)	`GAGCCC/TAGCCA`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs140213231^1,2		--	53438970(+)	`GGAATA/GCTGGG`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs183100106^1,2		--	53439003(+)	`TGGTTA/GAAGGC`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs200461801^1,2		--	53439026(+)	`AACAC-/ACTT AATTA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs187693346^1,2		--	53439042(+)	`TCATGA/TTTCTC`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs190939564^1,2		--	53439043(+)	`CATGAA/TTCTCG`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs184032561^1,2		--	53439054(+)	`ATTACA/TTAATC`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs145234257^1,2		--	53439099(+)	`CTTGCC/TCTTTC`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TENC1 (53440753 - 53458163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TENC1
6 CNVs: 49091 49090 49094 49089 49092 49093
1 Indel: 71512

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TENC1 for disorders           About GeneDecksing

OMIM gene information: 607717    OMIM disorders: --

5 diseases for TENC1:    About MalaCards

kidney cancer liver cancer hepatocellular carcinoma ataxia

carcinoma

Export disorders for TENC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TENC1 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with TENC1)

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C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PubMed id 15817639)^{1, 2} Hafizi S.... Dahlbaeck B. (2005)
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PubMed id 11792844)^{1, 2} Chen H.... Lo S.H. (2002)
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)^{1, 2} Hafizi S.... Dahlbaeck B. (2002)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PubMed id 20069572)^{1, 9} Clark K....Critchley D.R. (2010)
Solution structure of the phosphotyrosine binding (PTB ) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC 1) peptide reveals a novel peptide binding mode. (PubMed id 22645138)¹ Chen L....Zhu G. (2012)
The protein-tyrosine kinase Syk interacts with the C-t erminal region of tensin2. (PubMed id 22019427)¹ Moon K.D....Geahlen R.L. (2012)
Genome-wide association study identifies new prostate cancer susceptibility loci. (PubMed id 21743057)¹ Schumacher F.R....Kraft P. (2011)
Tensin2 is a novel mediator in thrombopoietin (TPO)-i nduced cellular proliferation by promoting Akt signaling. (PubMed id 21527831)¹ Jung A.S....Kaushansky K. (2011)
Solution structure of tensin2 SH2 domain and its phos photyrosine-independent interaction with DLC-1. (PubMed id 21765928)¹ Dai K....Tu X. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23371	HGNC: 19737	AceView: TENC1	Ensembl:ENSG00000111077	euGenes: HUgn23371
ECgene: TENC1	H-InvDB: TENC1

(According to HUGE)
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HUGE: KIAA1075

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TENC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TENC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TENC1 gene:
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GeneCards and IP:
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tensin like C1 domain containing phosphatase (tensin 2)

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tensin like C1 domain containing phosphatase (tensin 2)

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