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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TENC1 Gene

protein-coding   GIFtS: 55
GCID: GC12P053440

Tensin Like C1 Domain Containing Phosphatase (Tensin 2)

(Previous name: tensin like C1 domain-containing phosphatase)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tensin Like C1 Domain Containing Phosphatase (Tensin 2)1 2     C1TEN2 5
Tensin Like C1 Domain-Containing Phosphatase1 2     KIAA10753 5
Tensin 21 2     tensin-22
C1-TEN2 3     Tensin-Like C1 Domain-Containing Phosphatase2
TNS22 3     EC 3.1.3.-3
C1 Domain-Containing Phosphatase And Tensin Homolog2 3     Tensin-23

External Ids:    HGNC: 197371   Entrez Gene: 233712   Ensembl: ENSG000001110777   OMIM: 6077175   UniProtKB: Q63HR23   

Export aliases for TENC1 gene to outside databases

Previous GC identifers: GC12P053354 GC12P053157 GC12P051727 GC12P050483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TENC1 Gene:
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to
actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration.
Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have
been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for TENC1 Gene: 
TENC1 (tensin like C1 domain containing phosphatase (tensin 2)) is a protein-coding gene. Diseases associated with TENC1 include kidney cancer, and hepatocellular carcinoma. GO annotations related to this gene include phosphoprotein phosphatase activity and metal ion binding. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
Lowers AKT1 kinase activity and interferes with AKT1 signaling

Gene Wiki entry for TENC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TENC1 gene promoter:
         CHOP-10   Ik-2   C/EBPalpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTENC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TENC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TENC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

TENC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053440:  view genomic region     (about GC identifiers)

Start:
53,440,753 bp from pter      End:
53,458,163 bp from pter
Size:
17,411 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2 (See protein sequence)
Recommended Name: Tensin-like C1 domain-containing phosphatase  
Size: 1409 amino acids; 152580 Da
Subunit: Interacts with AXL
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Detected at the end of actin stress fibers
Sequence caution: Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI31504.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA83027.2; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAH56176.1; Type=Miscellaneous discrepancy;
Note=Intron retention;
5 PDB 3D structures from and Proteopedia for TENC1:
2DKQ (3D)        2KNO (3D)        2L6K (3D)        2LOZ (3D)        3HQC (3D)    
Secondary accessions: A2VDF2 A2VDF3 A2VDI8 A5PKY4 Q2NL80 Q76MW6 Q7Z5T9 Q8NFF9 Q8NFG0 Q96P25
Q9NT29 Q9UPS7
Alternative splicing: 5 isoforms:  Q63HR2-1   Q63HR2-2   Q63HR2-4   Q63HR2-5   Q63HR2-6   

Explore the universe of human proteins at neXtProt for TENC1: NX_Q63HR2

Explore proteomics data for TENC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q63HR2

  • TENC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TENC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_056134.2  NP_736610.2  NP_938072.1  

    ENSEMBL proteins: 
     ENSP00000369232   ENSP00000319756   ENSP00000319684   ENSP00000449363   ENSP00000447021  
     ENSP00000449361   ENSP00000473388   ENSP00000449165   ENSP00000393362  

    Human Recombinant Protein Products for TENC1: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IDA16951145

    TENC1 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    5/8 InterPro protein domains (see all 8):
     IPR014019 Phosphatase_tensin-typ
     IPR013625 PTB
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR006020 PTyr_interaction_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q63HR2

    ProtoNet protein and cluster: Q63HR2

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    TENC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENC1_HUMAN, Q63HR2
    Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
    Lowers AKT1 kinase activity and interferes with AKT1 signaling

         Enzyme Number (IUBMB): EC 3.1.3.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding IPI16273093
    GO:0046872metal ion binding IEA--
         
    TENC1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tenc1):
     adipose tissue  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system 

    TENC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TENC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TENC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TENC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TENC1 

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TENC1 (see all 12):
    hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTENC1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TENC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TENC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling
    2Adhesion
    Adhesion
    3PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for TENC1
        Cytoskeletal Signaling
    PI3K / Akt Signaling
    Adhesion



    TENC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TENC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for TENC1 (Q63HR22, 3 ENSP000003197564) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74780 MINT-74778 MINT-74781 MINT-74779 I2D: score=2 STRING: ENSP00000269571
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2870938 I2D: score=3 STRING: ENSP00000344782
    ITGB7P260102, 3, ENSP000002670824MINT-61567 I2D: score=3 STRING: ENSP00000267082
    ITGB5P180842, 3, ENSP000002961814MINT-61566 I2D: score=2 STRING: ENSP00000296181
    ITGB3P051062, 3MINT-61480 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0008285negative regulation of cell proliferation IMP16951145
    GO:0014850response to muscle activity IEA--
    GO:0019725cellular homeostasis IEA--
    GO:0032963collagen metabolic process IEA--

    TENC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TENC1

    10/843 HMDB Compounds for TENC1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about TENC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TENC1 gene (3 alternative transcripts): 
    NM_015319.2  NM_170754.2  NM_198316.1  

    Unigene Cluster for TENC1:

    Tensin like C1 domain containing phosphatase (tensin 2)
    Hs.6147  [show with all ESTs]
    Unigene Representative Sequence: BC150259
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000379902(uc001sbl.3) ENST00000314276(uc001sbn.3) ENST00000549498(uc001sbm.3)
    ENST00000551302 ENST00000314250(uc001sbp.3) ENST00000552403 ENST00000549311(uc001sbo.1 uc001sbr.3)
    ENST00000546602(uc001sbq.3) ENST00000552570(uc009zmr.3) ENST00000549700
    ENST00000551693 ENST00000549789 ENST00000547223 ENST00000602335 ENST00000546759
    ENST00000551583 ENST00000546772 ENST00000550660
    miRNA
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    hsa-miR-374b* hsa-miR-3679-3p hsa-miR-1178 hsa-miR-3607-5p hsa-miR-185* hsa-miR-767-3p hsa-miR-2278 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTENC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB028998.2 AF417490.1 AF518728.1 AF518729.1 AK131320.1 AK172747.1 AL137564.1 BC054099.1 
    BC110854.1 BC129828.1 BC129829.1 BC131503.1 BC142668.1 BC142712.1 BC150259.1 BX647126.1 
    CR936725.1 

    20 DOTS entries:

    DT.100648283  DT.95295531  DT.95151181  DT.449115  DT.121118050  DT.40269374  DT.100651420  DT.101982588 
    DT.100724559  DT.91689288  DT.100648284  DT.92441328  DT.95151174  DT.97784943  DT.101961374  DT.121118477 
    DT.95101213  DT.121117936  DT.121118973  DT.92036991 

    24/292 AceView cDNA sequences (see all 292):

    BM976564 CN479477 D30992 CO247269 AL137564 BX647126 CA427820 BU521796 
    CA390952 BU736594 BF941721 CR607439 BQ774302 BM693074 BM704273 AI767231 
    D31134 BU616495 BE502630 BF115185 CD172215 AW590137 BI768276 AF518729 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TENC1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:        -     -     -     -     -     -           -                 -                 -                             -                                   -   
    SP2:                          -     -     -           -                 -                 -                             -                                   -   
    SP3:                                                  -                 -                 -                             -                                   -   
    SP4:                                                  -                 -                 -                             -                                   -   
    SP5:                                                                                                                                                        -   

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
    SP1:              -                                                     -     -                                   -                                 
    SP2:              -                                                     -     -                                   -                                 
    SP3:              -                                                     -     -                                   -                                 
    SP4:              -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:              -                       -                             -     -                                   -                                 


    ECgene alternative splicing isoforms for TENC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TENC1 expression in normal human tissues (normalized intensities)      TENC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGGGGAA
    TENC1 Expression
    About this image


    TENC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Rib
             sensory organ/ear/inner ear   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   
     
     Heart (Cardiovascular System)
             atrial myocardium   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Limb (Muscoskeletal System)
             Autopod

    See TENC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TENC1

    SOURCE GeneReport for Unigene cluster: Hs.6147

    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and
    small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including TENC1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TENC1 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tenc11 , 5 tensin like C1 domain-containing phosphatase1, 5 86.28(n)1
    90.64(a)1
      15 (57.29 cM)5
    2090391  NM_153533.21  NP_705761.21 
     1021029885 
    lizard
    (Anolis carolinensis)
    Reptilia TENC16
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343212.1(2853076-2901698)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7991091 tensin-like C1 domain-containing phosphatase-like 56.3(n)
    54.6(a)
      799109  XM_001921008.1  XP_001921043.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    28(a)
    1 → many
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Protein TAG-163, isoform c
    20(a)
    1 → many
    I(5583405-5597332)


    ENSEMBL Gene Tree for TENC1 (if available)
    TreeFam Gene Tree for TENC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TENC1 gene
    PTEN2  DNAJC62  TNS12  TPTE2  TNS42  TNS32  GAK2  TPTE22  
    4 SIMAP similar genes for TENC1 using alignment to 6 protein entries:     TENC1_HUMAN (see all proteins):
    DKFZp434G162    PTEN    TNS4    TNS3

    TENC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 SNPs in TENC1 are shown (see all 342)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107835591,2
    C,F,A,H--53274744(+) TCTTTC/TTGCCT 1 -- us2k122Minor allele frequency- T:0.35NS EA NA CSA WA 2350
    rs748913011,2
    C,F--53274757(+) GTCCCG/TCCGGG 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs763594581,2
    C,F--53274768(+) TCAGGC/TTCTCC 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs2002923901,2
    C--53450424(+) GGACA-/CAAT  
            
    AATCA
    3 -- int10--------
    rs1384644991,2
    --53450458(+) CTTCAG/TTATGG 3 -- int10--------
    rs1426511171,2
    --53450584(+) TTTTAC/TAGATG 3 -- int10--------
    rs1502592851,2
    --53450592(+) ATGAAA/GAAACT 3 -- int10--------
    rs21397741,2
    C,F--53450625(-) tgttgG/Agcctc 3 -- int13Minor allele frequency- A:0.01NA 142
    rs1163764391,2
    F--53450678(+) CACTAC/TTCTGG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs2010492501,2
    --53450800(+) AGGGCA/GGACCA 6 A syn10--------

    HapMap Linkage Disequilibrium report for TENC1 (53440753 - 53458163 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TENC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899098CNV Loss21882294
    esv28917CNV Loss19812545
    nsv470294CNV Loss18288195
    nsv899099CNV Loss21882294
    nsv517066CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607717    OMIM disorders: --

    4 diseases for TENC1:    About MalaCards
    kidney cancer    hepatocellular carcinoma    prostate cancer    prostatitis


    TENC1 for disorders           About GeneDecksing


    Export disorders for TENC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TENC1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TENC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PubMed id 15817639)1, 2 Hafizi S.... Dahlbaeck B. (2005)
    2. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PubMed id 11792844)1, 2 Chen H.... Lo S.H. (2002)
    3. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    5. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PubMed id 20069572)1, 9 Clark K....Critchley D.R. (2010)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Interaction of DISC1 with the PTB domain of Tensin2. (PubMed id 23233134)1 Goudarzi S....Hafizi S. (2013)
    8. Solution structure of the phosphotyrosine binding (PTB ) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC 1) peptide reveals a novel peptide binding mode. (PubMed id 22645138)1 Chen L....Zhu G. (2012)
    9. The protein-tyrosine kinase Syk interacts with the C-t erminal region of tensin2. (PubMed id 22019427)1 Moon K.D....Geahlen R.L. (2012)
    10. Genome-wide association study identifies new prostate cancer susceptibility loci. (PubMed id 21743057)1 Schumacher F.R....Kraft P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23371 HGNC: 19737 AceView: TENC1 Ensembl:ENSG00000111077 euGenes: HUgn23371
    ECgene: TENC1 H-InvDB: TENC1

    (According to HUGE)
    About This Section
    HUGE: KIAA1075

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TENC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TENC1 gene:
    Search GeneIP for patents involving TENC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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