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Aliases for TEN1 Gene

Aliases for TEN1 Gene

  • TEN1 CST Complex Subunit 2 3
  • Telomere Length Regulation Protein TEN1 Homolog 3 4
  • Protein Telomeric Pathways With STN1 Homolog 3 4
  • C17orf106 3 4
  • TEN1 Telomerase Capping Complex Subunit Homolog (S. Cerevisiae) 2
  • Telomeric Pathways In Association With Stn1, Number 1 3
  • TEN1 Telomerase Capping Complex Subunit Homolog 3
  • Chromosome 17 Open Reading Frame 106 2
  • CST Complex Subunit TEN1 3
  • C17orf106, 6

External Ids for TEN1 Gene

Previous Symbols for TEN1 Gene

  • C17orf106

Summaries for TEN1 Gene

Entrez Gene Summary for TEN1 Gene

  • C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

GeneCards Summary for TEN1 Gene

TEN1 (TEN1 CST Complex Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TEN1 Gene

  • Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEN1 Gene

Genomics for TEN1 Gene

Genomic Location for TEN1 Gene

Start:
75,979,217 bp from pter
End:
76,000,586 bp from pter
Size:
21,370 bases
Orientation:
Plus strand

Genomic View for TEN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEN1 Gene

No data available for Regulatory Elements for TEN1 Gene

Proteins for TEN1 Gene

  • Protein details for TEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WV5-TEN1L_HUMAN
    Recommended name:
    CST complex subunit TEN1
    Protein Accession:
    Q86WV5
    Secondary Accessions:
    • I3L0C7

    Protein attributes for TEN1 Gene

    Size:
    123 amino acids
    Molecular mass:
    13856 Da
    Quaternary structure:
    • Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1/OBFC1. Interacts with STN1/OBFC1; the interaction is direct.
    SequenceCaution:
    • Sequence=AAH47782.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEN1 Gene

neXtProt entry for TEN1 Gene

Proteomics data for TEN1 Gene at MOPED

Post-translational modifications for TEN1 Gene

No Post-translational modifications

Other Protein References for TEN1 Gene

No data available for DME Specific Peptides for TEN1 Gene

Domains for TEN1 Gene

Protein Domains for TEN1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TEN1L_HUMAN
Domain:
  • Contains 1 OB DNA-binding domain.:
    • Q86WV5
Family:
  • Belongs to the TEN1 family.:
    • Q86WV5
genes like me logo Genes that share domains with TEN1: view

No data available for Gene Families for TEN1 Gene

Function for TEN1 Gene

Molecular function for TEN1 Gene

UniProtKB/Swiss-Prot Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.

Gene Ontology (GO) - Molecular Function for TEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 19854130
genes like me logo Genes that share ontologies with TEN1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TEN1 Gene

Localization for TEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEN1 Gene

Nucleus. Chromosome, telomere.

Gene Ontology (GO) - Cellular Components for TEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19854130
GO:0005634 nucleus IDA 19854130
GO:0070188 Stn1-Ten1 complex ISS --
genes like me logo Genes that share ontologies with TEN1: view

Pathways for TEN1 Gene

SuperPathways for TEN1 Gene

No Data Available

Interacting Proteins for TEN1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380762%0d%0a9606.ENSP00000224950%0d%0a9606.ENSP00000313759%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000380762 Q86WV5-TEN1L_HUMAN for TEN1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TEN1 Gene

None

No data available for Pathways by source for TEN1 Gene

Transcripts for TEN1 Gene

mRNA/cDNA for TEN1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEN1 Gene

TEN1 telomerase capping complex subunit homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEN1 Gene

No ASD Table

Relevant External Links for TEN1 Gene

GeneLoc Exon Structure for
TEN1
ECgene alternative splicing isoforms for
TEN1

Expression for TEN1 Gene

mRNA expression in normal human tissues for TEN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEN1 Gene

SOURCE GeneReport for Unigene cluster for TEN1 Gene Hs.593566

genes like me logo Genes that share expressions with TEN1: view

Orthologs for TEN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEN1 36
  • 98.64 (n)
  • 100 (a)
TEN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEN1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEN1 36
  • 82.92 (n)
  • 81.82 (a)
TEN1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ten1 36
  • 72.6 (n)
  • 64.41 (a)
Ten1 16
Ten1 37
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEN1 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEN1 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ten1 36
  • 77.12 (n)
  • 69.49 (a)
chicken
(Gallus gallus)
Aves C18H17ORF106 36
  • 65.81 (n)
  • 61.54 (a)
C18H17ORF106 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEN1 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ten1 36
  • 59.44 (n)
  • 53.33 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-89i1.2 36
  • 50.71 (n)
  • 43.59 (a)
TEN1 37
  • 32 (a)
OneToOne
Species with no ortholog for TEN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEN1 Gene

ENSEMBL:
Gene Tree for TEN1 (if available)
TreeFam:
Gene Tree for TEN1 (if available)

Paralogs for TEN1 Gene

Selected SIMAP similar genes for TEN1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TEN1 Gene

genes like me logo Genes that share paralogs with TEN1: view

No data available for Paralogs for TEN1 Gene

Variants for TEN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEN1 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv908825 CNV Loss 21882294
nsv908826 CNV Loss 21882294

Relevant External Links for TEN1 Gene

HapMap Linkage Disequilibrium report
TEN1

No data available for Sequence variations from dbSNP and Humsavar for TEN1 Gene

Disorders for TEN1 Gene

No disorders were found for TEN1 Gene.

No data available for UniProtKB/Swiss-Prot for TEN1 Gene

Publications for TEN1 Gene

  1. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. (PMID: 19854130) Miyake Y. … Ishikawa F. (Mol. Cell 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Structure of the human telomeric Stn1-Ten1 capping complex. (PMID: 23826127) Bryan C. … Skordalakes E. (PLoS ONE 2013) 3 4
  4. CST for the grand finale of telomere replication. (PMID: 23851344) Chen L.Y. … Lingner J. (Nucleus 2013) 3
  5. Human TEN1 maintains telomere integrity and functions in genome-wide replication restart. (PMID: 24025336) Kasbek C. … Price C.M. (J. Biol. Chem. 2013) 3

Products for TEN1 Gene

Sources for TEN1 Gene

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