TEN1 Gene
protein-coding GIFtS: 34
GCID: GC17P073978
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TEN1 telomerase capping complex subunit homolog (S. cerevisiae)(Previous name: chromosome 17 open reading frame 106 )
(Previous symbol: C17orf106)
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Aliases
for TEN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| TEN1 Telomerase Capping Complex Subunit Homolog (S. Cerevisiae)1 2 | | FLJ397851 | | C17orf1061 2 3 5 | | Chromosome 17 Open Reading Frame 1061 | | Protein Telomeric Pathways With STN1 Homolog2 3 | | CST Complex Subunit TEN12 | | Telomere Length Regulation Protein TEN1 Homolog2 3 | | Telomeric Pathways In Association With Stn1, Number 12 |
| External Ids: | HGNC: 372421 | Entrez Gene: 1001349342 | Ensembl: ENSG000002579497 | OMIM: 6131305 | UniProtKB: Q86WV53 |
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| | ORGUL members: | |
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| NONCODE:n410542 | |
Export aliases for TEN1 gene to outside databases
Summaries
for TEN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TEN1:
C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1(C17ORF68; MIM 613129) (Miyake et al., 2009 (PubMed 19854130)).(supplied by OMIM, Nov 2009)
UniProtKB/Swiss-Prot: TEN1L_HUMAN, Q86WV5Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protecttelomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independentmanner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CSTcomplex has probably a more general role in DNA metabolism at non-telomeric sites
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Genomic Views
for TEN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TEN1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TEN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1TEN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P073978: view genomic region
(about GC identifiers)
Start:
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73,975,301 bp from pter |
End:
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73,996,667 bp from pter |
Size:
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21,367 bases |
Orientation:
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plus strand |
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Proteins
for TEN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TEN1L_HUMAN, Q86WV5 (See
protein sequence)Recommended Name: CST complex subunit TEN1 Size: 122 amino acids; 13725 Da
Subunit: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1/OBFC1. Interacts withSTN1/OBFC1; the interaction is direct
Subcellular location: Nucleus. Chromosome, telomereExplore the universe of human proteins at neXtProt for TEN1: NX_Q86WV5
TEN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001106795.2
ENSEMBL proteins: ENSP00000380762 ENSP00000465866 ENSP00000465299 ENSP00000464792 ENSP00000405279
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TEN1 for ontologies About GeneDecksing
TEN1 Antibody Products:
Assay Products for TEN1: |
Protein
Domains /
Families
for TEN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86WV5 UniProtKB/Swiss-Prot: TEN1L_HUMAN, Q86WV5Similarity: Belongs to the TEN1 family |
Function
for TEN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TEN1L_HUMAN, Q86WV5Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protecttelomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independentmanner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CSTcomplex has probably a more general role in DNA metabolism at non-telomeric sites
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TEN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEN1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TEN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for TEN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEN1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TEN1 (ENSP000004052794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TEN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TEN1
Search CenterWatch for drugs/clinical trials and news about TEN1 / TEN1L
|
Transcripts
for TEN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TEN1 gene: NM_001113324.2 Unigene Cluster for TEN1: TEN1 telomerase capping complex subunit homolog (S. cerevisiae) Hs.593566 [show with all ESTs]Unigene Representative Sequence: BQ0600946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397640 ENST00000588202 ENST00000590676 ENST00000586891 ENST00000585710
ENST00000416485
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TEN1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEN1 |
Additional cDNA sequence: BC047782.1 BX648576.1 FJ790671.1 7 DOTS entries: DT.92434871 DT.452082 DT.455141 DT.302659 DT.100025740 DT.410755 DT.95164072
GeneLoc Exon Structure
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Expression
for TEN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TEN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGTTCCA
About this image
See TEN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TEN1
SOURCE GeneReport for Unigene cluster: Hs.593566
SABiosciences Custom PCR Arrays for TEN1
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TEN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEN1 |
Orthologs
for TEN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TEN1 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for TEN1 (if available)
TreeFam Gene Tree for TEN1 (if available) |
Paralogs
for TEN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TEN1 gene
1 SIMAP similar gene for TEN1 using alignment to 6 protein entries: TEN1L_HUMAN (see all proteins):C8orf44
TEN1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TEN1
PGOHUM00000236658
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Genomic Variants
for TEN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TEN1 (73975301 - 73996667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TEN1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TEN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TEN1 for disorders About MalaCards
TEN1 for disorders About GeneDecksing
OMIM gene information: 613130
OMIM disorders: --
Export disorders for TEN1 gene to outside databases
|
Publications
for TEN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TEN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TEN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to si ngle-stranded DNA and protects telomeres independently of the Pot1 pathway. (PubMed id 19854130)1, 2, 3 Miyake Y....Ishikawa F. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The human CST complex is a terminator of telomerase ac tivity. (PubMed id 22763445)1 Chen L.Y....Lingner J. (2012)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for TEN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TEN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TEN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TEN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TEN1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TEN1 gene:
Search GeneIP for patents involving TEN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TEN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TEN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEN1 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TEN1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TEN1 | | OriGene Custom Protein Services for TEN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEN1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEN1 |
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 |  |  |  | |
| | | | Search Tocris compounds for TEN1 |
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 | | | TEN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TEN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEN1 |
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Last full update: 18 Mar 2013 -
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