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Aliases for TELO2 Gene

Aliases for TELO2 Gene

  • Telomere Maintenance 2 2 3
  • Protein Clk-2 Homolog 3 4
  • KIAA0683 4 6
  • HCLK2 4 6
  • TEL2 3 6
  • CLK2 3 6
  • TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) 2
  • Telomere Length Regulation Protein TEL2 Homolog 3
  • TEL2, Telomere Maintenance 2, Homolog 3
  • EC 1.1.1.27 64
  • EC 2.7.11.1 64

External Ids for TELO2 Gene

Summaries for TELO2 Gene

Entrez Gene Summary for TELO2 Gene

  • This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]

GeneCards Summary for TELO2 Gene

TELO2 (Telomere Maintenance 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Fanconi anemia pathway (KEGG). GO annotations related to this gene include protein complex binding and protein complex scaffold.

UniProtKB/Swiss-Prot for TELO2 Gene

  • Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.

Gene Wiki entry for TELO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TELO2 Gene

Genomics for TELO2 Gene

Genomic Location for TELO2 Gene

Start:
1,493,344 bp from pter
End:
1,510,459 bp from pter
Size:
17,116 bases
Orientation:
Plus strand

Genomic View for TELO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TELO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TELO2 Gene

Regulatory Elements for TELO2 Gene

Proteins for TELO2 Gene

  • Protein details for TELO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4R8-TELO2_HUMAN
    Recommended name:
    Telomere length regulation protein TEL2 homolog
    Protein Accession:
    Q9Y4R8
    Secondary Accessions:
    • D3DU73
    • O75168
    • Q7LDV4
    • Q9BR21

    Protein attributes for TELO2 Gene

    Size:
    837 amino acids
    Molecular mass:
    91747 Da
    Quaternary structure:
    • Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Component of the mTORC1 and mTORC2 complexes.
    Miscellaneous:
    • Cells overexpressing TELO2 are hypersensitive to hydroxyurea (HU) and undergo apoptotic death in response to treatment with HU
    SequenceCaution:
    • Sequence=BAA31658.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TELO2 Gene

neXtProt entry for TELO2 Gene

Proteomics data for TELO2 Gene at MOPED

Selected DME Specific Peptides for TELO2 Gene

Post-translational modifications for TELO2 Gene

  • Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage.
  • Phosphorylated at Ser-485 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein.
  • Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36, Lys51, Lys159, and Lys392

Other Protein References for TELO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TELO2 Gene

Protein Domains for TELO2 Gene

UniProtKB/Swiss-Prot:

TELO2_HUMAN
Family:
  • Belongs to the TEL2 family.:
    • Q9Y4R8
genes like me logo Genes that share domains with TELO2: view

No data available for Gene Families for TELO2 Gene

Function for TELO2 Gene

Molecular function for TELO2 Gene

UniProtKB/Swiss-Prot Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.

Enzyme Numbers (IUBMB) for TELO2 Gene

Gene Ontology (GO) - Molecular Function for TELO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 18160036
GO:0032403 protein complex binding IDA 20864032
GO:0032947 protein complex scaffold IEA --
genes like me logo Genes that share ontologies with TELO2: view

Phenotypes for TELO2 Gene

genes like me logo Genes that share phenotypes with TELO2: view

Animal Models for TELO2 Gene

MGI Knock Outs for TELO2:

miRNA for TELO2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for TELO2 Gene

Localization for TELO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TELO2 Gene

Cytoplasm. Membrane. Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TELO2 Gene COMPARTMENTS Subcellular localization image for TELO2 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TELO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TELO2: view

Pathways for TELO2 Gene

genes like me logo Genes that share pathways with TELO2: view

Pathways by source for TELO2 Gene

1 BioSystems pathway for TELO2 Gene
1 KEGG pathway for TELO2 Gene

Gene Ontology (GO) - Biological Process for TELO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032006 regulation of TOR signaling IMP 23263282
genes like me logo Genes that share ontologies with TELO2: view

Transcripts for TELO2 Gene

Unigene Clusters for TELO2 Gene

TEL2, telomere maintenance 2, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TELO2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: - -
SP8: -
SP9:
SP10: -

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TELO2 Gene

GeneLoc Exon Structure for
TELO2
ECgene alternative splicing isoforms for
TELO2

Expression for TELO2 Gene

mRNA expression in normal human tissues for TELO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TELO2 Gene

SOURCE GeneReport for Unigene cluster for TELO2 Gene Hs.271044

genes like me logo Genes that share expressions with TELO2: view

Orthologs for TELO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TELO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TELO2 36
  • 98.56 (n)
  • 97.92 (a)
TELO2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TELO2 36
  • 81.66 (n)
  • 77.21 (a)
TELO2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TELO2 36
  • 80.13 (n)
  • 76.56 (a)
TELO2 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Telo2 36
  • 78.89 (n)
  • 75.15 (a)
Telo2 16
Telo2 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TELO2 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Telo2 36
  • 78.82 (n)
  • 75.69 (a)
chicken
(Gallus gallus)
Aves TELO2 36
  • 65.98 (n)
  • 62.62 (a)
TELO2 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TELO2 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia telo2 36
  • 56.07 (n)
  • 52 (a)
zebrafish
(Danio rerio)
Actinopterygii telo2 36
  • 54.9 (n)
  • 48.01 (a)
telo2 37
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10836 37
  • 24 (a)
OneToOne
Species with no ortholog for TELO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TELO2 Gene

ENSEMBL:
Gene Tree for TELO2 (if available)
TreeFam:
Gene Tree for TELO2 (if available)

Paralogs for TELO2 Gene

No data available for Paralogs for TELO2 Gene

Variants for TELO2 Gene

Sequence variations from dbSNP and Humsavar for TELO2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2235624 - 1,495,447(+) GACGC(A/G)GCCCG reference, missense, nc-transcript-variant
rs2235625 -- 1,496,607(+) GGCCC(C/T)TCCCG intron-variant
rs2235626 -- 1,496,611(+) CCTCC(C/T)GGTTC intron-variant
rs2235627 -- 1,496,631(+) CCTGG(A/C)GTGCG intron-variant
rs2235628 -- 1,496,729(+) CCAAC(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TELO2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2505n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
dgv2527n71 CNV Loss 21882294
dgv2528n71 CNV Loss 21882294
dgv2531n71 CNV Loss 21882294
nsv819259 CNV Gain 19587683
nsv905004 CNV Loss 21882294
dgv2535n71 CNV Loss 21882294
nsv905007 CNV Gain 21882294
nsv457332 CNV Loss 19166990
nsv905008 CNV Loss 21882294
dgv2536n71 CNV Loss 21882294
nsv905015 CNV Loss 21882294
dgv2537n71 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv905018 CNV Loss 21882294
esv2750345 CNV Deletion 23290073
esv2741194 CNV Deletion 23290073
esv2750346 CNV Deletion 23290073
esv1008115 CNV Deletion 20482838

Relevant External Links for TELO2 Gene

HapMap Linkage Disequilibrium report
TELO2
Human Gene Mutation Database (HGMD)
TELO2

Disorders for TELO2 Gene

No disorders were found for TELO2 Gene.

No data available for UniProtKB/Swiss-Prot for TELO2 Gene

Publications for TELO2 Gene

  1. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. (PMID: 12670948) Jiang N. … Hekimi S. (J. Biol. Chem. 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. (PMID: 20427287) Kaizuka T. … Mizushima N. (J. Biol. Chem. 2010) 3 4

Products for TELO2 Gene

  • Addgene plasmids for TELO2

Sources for TELO2 Gene

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