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TEKT5 Gene(Protein Coding)

Tektin 5

GCID:
GC16M010627
GIFtS:
41
Genes Participants
UDN Logo

Aliases for TEKT5 Gene

Aliases for TEKT5 Gene

  • Tektin 5 2 3 5
  • Tektin-5 3
  • CT149 3

External Ids for TEKT5 Gene

Previous GeneCards Identifiers for TEKT5 Gene

  • GC16M010629
  • GC16M010721

Summaries for TEKT5 Gene

GeneCards Summary for TEKT5 Gene

TEKT5 (Tektin 5) is a Protein Coding gene. An important paralog of this gene is TEKT3.

UniProtKB/Swiss-Prot for TEKT5 Gene

  • May be a structural component of the sperm flagellum.

Additional gene information for TEKT5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT5 Gene

Genomics for TEKT5 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TEKT5 Gene

Promoters and enhancers for TEKT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16I010743 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.8 -2.0 -1967 3.5 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B TEKT5 NUBP1 HNRNPCP4 CIITA ENSG00000256013 SOCS1 PIR44837 GC16P010485
GH16I010742 Enhancer 0.6 Ensembl 550.8 +0.3 315 0.2 NFIA ZFP64 ZEB2 ZNF592 NFIC GABPB1 RCOR1 ZNF600 HNF4A MGA NUBP1 TEKT5 ENSG00000256013 GC16P010738 GC16P010485
GH16I010694 Promoter 0.6 EPDnew 550.2 +47.5 47466 0.1 NFE2 TEKT5 LOC105371079 MTCYBP33 GC16P010485
GH16I010690 Enhancer 0.4 FANTOM5 71 +51.6 51620 0.2 CREB1 LOC105371079 TEKT5 CLEC16A EMP2 GC16P010485
GH16I010736 Enhancer 1.3 Ensembl ENCODE 7.5 +4.3 4297 2.9 HDGF FOXA2 PKNOX1 ARID4B IRF4 YY1 ZNF143 ZNF207 FOS KLF13 GC16P010738 ENSG00000256013 HNRNPCP4 TEKT5 TVP23A MTATP6P24 GC16P010485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEKT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEKT5 gene promoter:

Genomic Locations for TEKT5 Gene

Genomic Locations for TEKT5 Gene
chr16:10,581,369-10,742,416
(GRCh38/hg38)
Size:
161,048 bases
Orientation:
Minus strand
chr16:10,721,358-10,788,802
(GRCh37/hg19)

Genomic View for TEKT5 Gene

Genes around TEKT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TEKT5 Gene

Proteins for TEKT5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TEKT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M29-TEKT5_HUMAN
    Recommended name:
    Tektin-5
    Protein Accession:
    Q96M29
    Secondary Accessions:
    • A1L3Z3

    Protein attributes for TEKT5 Gene

    Size:
    485 amino acids
    Molecular mass:
    56294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT5 Gene

Protein Expression for TEKT5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TEKT5 Gene

No Post-translational modifications

Other Protein References for TEKT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEKT5 Gene

Domains & Families for TEKT5 Gene

Gene Families for TEKT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M29

UniProtKB/Swiss-Prot:

TEKT5_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT5: view

Function for TEKT5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TEKT5 Gene

UniProtKB/Swiss-Prot Function:
May be a structural component of the sperm flagellum.

Phenotypes From GWAS Catalog for TEKT5 Gene

Gene Ontology (GO) - Molecular Function for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT5: view
genes like me logo Genes that share phenotypes with TEKT5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT5 Gene

Localization for TEKT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT5 Gene

Cell projection, cilium, flagellum. Note=Appears to be associated with flagellar accessory structures and not the axoneme. {ECO:0000250 UniProtKB:G5E8A8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT5 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005929 cilium IEA --
GO:0036126 sperm flagellum IBA,IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TEKT5: view

Pathways & Interactions for TEKT5 Gene

SuperPathways for TEKT5 Gene

PathCards logo More details on SuperPathways for TEKT5
No Data Available

Gene Ontology (GO) - Biological Process for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility IBA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT5: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT5 Gene

Drugs & Compounds for TEKT5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TEKT5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TEKT5 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEKT5 Gene

Tektin 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT5 Gene

No ASD Table

Relevant External Links for TEKT5 Gene

GeneLoc Exon Structure for
TEKT5
ECgene alternative splicing isoforms for
TEKT5

Expression for TEKT5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT5 Gene

mRNA expression in normal human tissues for TEKT5 Gene
mRNA expression by GTEx for TEKT5 GenemRNA expression by BioGPS for TEKT5 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT5 Gene

This gene is overexpressed in Testis (x40.0).

Protein differential expression in normal tissues from HIPED for TEKT5 Gene

This gene is overexpressed in Tlymphocyte (42.1) and Testis (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT5 Gene



Protein tissue co-expression partners for TEKT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT5 Gene:

TEKT5

SOURCE GeneReport for Unigene cluster for TEKT5 Gene:

Hs.143519

Evidence on tissue expression from TISSUES for TEKT5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT5 Gene

Orthologs for TEKT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TEKT5 33 34
  • 98.35 (n)
dog
(Canis familiaris)
 Mammalia TEKT5 33 34
  • 88.73 (n)
cow
(Bos Taurus)
 Mammalia TEKT5 33 34
  • 87.54 (n)
mouse
(Mus musculus)
 Mammalia Tekt5 33 16 34
  • 82.69 (n)
rat
(Rattus norvegicus)
 Mammalia Tekt5 33
  • 82.47 (n)
oppossum
(Monodelphis domestica)
 Mammalia TEKT5 34
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TEKT5 34
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TEKT5 33 34
  • 66.53 (n)
lizard
(Anolis carolinensis)
 Reptilia TEKT5 34
  • 69 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG17450 34
  • 29 (a)
 ManyToMany
CG32819 34
  • 29 (a)
 ManyToMany
CG32820 34
  • 29 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 52 (a)
 OneToOne
Species where no ortholog for TEKT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEKT5 Gene

ENSEMBL:
Gene Tree for TEKT5 (if available)
TreeFam:
Gene Tree for TEKT5 (if available)

Paralogs for TEKT5 Gene

Paralogs for TEKT5 Gene

(4) SIMAP similar genes for TEKT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TEKT5: view

Variants for TEKT5 Gene

Sequence variations from dbSNP and Humsavar for TEKT5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000013000 -- 10,720,669(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000028954 -- 10,638,622(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000053760 -- 10,723,612(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000092528 -- 10,634,036(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000122237 -- 10,659,046(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT5 Gene

Variant ID Type Subtype PubMed ID
esv1298043 CNV insertion 17803354
esv1434518 CNV insertion 17803354
esv1671601 CNV insertion 17803354
esv2658677 CNV deletion 23128226
esv2674260 CNV deletion 23128226
esv2674786 CNV deletion 23128226
esv2713964 CNV deletion 23290073
esv3351950 CNV insertion 20981092
esv3376019 CNV insertion 20981092
esv3418682 CNV insertion 20981092
esv3582009 CNV loss 25503493
esv3637908 CNV loss 21293372
esv3637909 CNV loss 21293372
esv3637910 CNV loss 21293372
esv3637911 CNV loss 21293372
esv3637912 CNV loss 21293372
esv3892791 CNV loss 25118596
esv5815 CNV loss 19470904
nsv1040428 CNV gain 25217958
nsv1051030 CNV loss 25217958
nsv1071263 CNV deletion 25765185
nsv522111 CNV loss 19592680
nsv827550 CNV loss 20364138
nsv833140 CNV loss 17160897
nsv958203 CNV deletion 24416366

Variation tolerance for TEKT5 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT5 Gene

Human Gene Mutation Database (HGMD)
TEKT5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT5 Gene

Disorders for TEKT5 Gene

Additional Disease Information for TEKT5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TEKT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT5 Gene

Publications for TEKT5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 58
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58

Products for TEKT5 Gene

Sources for TEKT5 Gene

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