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Aliases for TEKT5 Gene

Aliases for TEKT5 Gene

  • Tektin 5 2 3 5
  • Tektin-5 3
  • CT149 3

External Ids for TEKT5 Gene

Previous GeneCards Identifiers for TEKT5 Gene

  • GC16M010629
  • GC16M010721

Summaries for TEKT5 Gene

GeneCards Summary for TEKT5 Gene

TEKT5 (Tektin 5) is a Protein Coding gene. An important paralog of this gene is TEKT3.

UniProtKB/Swiss-Prot for TEKT5 Gene

  • May be a structural component of the sperm flagellum.

Additional gene information for TEKT5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT5 Gene

Genomics for TEKT5 Gene

Regulatory Elements for TEKT5 Gene

Enhancers for TEKT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H010690 0.4 FANTOM5 71 +51.6 51621 0 TEKT5 CLEC16A LOC105371079 EMP2
GH16H010736 1.3 Ensembl ENCODE 7.5 +4.3 4298 2 HDGF FOXA2 PKNOX1 ARID4B YY1 ZNF143 ZNF207 FOS JUNB REST ENSG00000256013 HNRNPCP4 TEKT5 TVP23A GC16P010738 MTATP6P24
GH16H010752 1.4 FANTOM5 Ensembl ENCODE 6.8 -11.0 -10991 1 TBL1XR1 RB1 EBF1 RELA FOXK2 EED ETV6 RUNX3 CREM IKZF2 CIITA NUBP1 TEKT5 PIR44837
GH16H010743 1.1 ENCODE 6.8 -2.0 -1968 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 HNRNPCP4 CIITA ENSG00000256013 SOCS1 TEKT5 NUBP1 PIR44837
GH16H010729 0.8 ENCODE 6.8 +12.5 12508 0 CTCF JUN ZSCAN4 INSM2 MAX SIN3A KLF17 RAD21 RFX5 CTBP1 TEKT5 MTATP6P24 GC16P010738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEKT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEKT5 Gene

10,581,369 bp from pter
10,742,416 bp from pter
161,048 bases
Minus strand

Genomic View for TEKT5 Gene

Genes around TEKT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT5 Gene

Proteins for TEKT5 Gene

  • Protein details for TEKT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L3Z3

    Protein attributes for TEKT5 Gene

    485 amino acids
    Molecular mass:
    56294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT5 Gene

Post-translational modifications for TEKT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEKT5 Gene

Domains & Families for TEKT5 Gene

Gene Families for TEKT5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT5 Gene


Suggested Antigen Peptide Sequences for TEKT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tektin family.
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT5: view

Function for TEKT5 Gene

Molecular function for TEKT5 Gene

UniProtKB/Swiss-Prot Function:
May be a structural component of the sperm flagellum.

Phenotypes From GWAS Catalog for TEKT5 Gene

Gene Ontology (GO) - Molecular Function for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT5: view
genes like me logo Genes that share phenotypes with TEKT5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEKT5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT5 Gene

Localization for TEKT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT5 Gene

Cell projection, cilium, flagellum. Note=Appears to be associated with flagellar accessory structures and not the axoneme. {ECO:0000250 UniProtKB:G5E8A8}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT5 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005929 cilium IEA --
GO:0036126 sperm flagellum IBA,IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TEKT5: view

Pathways & Interactions for TEKT5 Gene

SuperPathways for TEKT5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility IBA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT5: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT5 Gene

Drugs & Compounds for TEKT5 Gene

No Compound Related Data Available

Transcripts for TEKT5 Gene

mRNA/cDNA for TEKT5 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEKT5 Gene

Tektin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEKT5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT5 Gene

No ASD Table

Relevant External Links for TEKT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEKT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT5 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT5 Gene

This gene is overexpressed in Testis (x40.0).

Protein differential expression in normal tissues from HIPED for TEKT5 Gene

This gene is overexpressed in Tlymphocyte (42.1) and Testis (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT5 Gene

Protein tissue co-expression partners for TEKT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT5 Gene:


SOURCE GeneReport for Unigene cluster for TEKT5 Gene:


Evidence on tissue expression from TISSUES for TEKT5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT5 Gene

Orthologs for TEKT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TEKT5 33 34
  • 98.35 (n)
(Canis familiaris)
Mammalia TEKT5 33 34
  • 88.73 (n)
(Bos Taurus)
Mammalia TEKT5 33 34
  • 87.54 (n)
(Mus musculus)
Mammalia Tekt5 33 16 34
  • 82.69 (n)
(Rattus norvegicus)
Mammalia Tekt5 33
  • 82.47 (n)
(Monodelphis domestica)
Mammalia TEKT5 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia TEKT5 34
  • 64 (a)
(Gallus gallus)
Aves TEKT5 33 34
  • 66.53 (n)
(Anolis carolinensis)
Reptilia TEKT5 34
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17450 34
  • 29 (a)
CG32819 34
  • 29 (a)
CG32820 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Species where no ortholog for TEKT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEKT5 Gene

Gene Tree for TEKT5 (if available)
Gene Tree for TEKT5 (if available)

Paralogs for TEKT5 Gene

Paralogs for TEKT5 Gene

(4) SIMAP similar genes for TEKT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TEKT5: view

Variants for TEKT5 Gene

Sequence variations from dbSNP and Humsavar for TEKT5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000013000 -- 10,720,669(+) CATAA(C/T)GTGAA intron-variant
rs1000028954 -- 10,638,622(+) TCATC(A/G)GCTCC intron-variant
rs1000053760 -- 10,723,612(+) ATTTT(A/T)TGGAG intron-variant
rs1000092528 -- 10,634,036(+) TCTAG(A/C)AGTGG intron-variant
rs1000122237 -- 10,659,046(+) GGTAT(A/C)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT5 Gene

Variant ID Type Subtype PubMed ID
esv1298043 CNV insertion 17803354
esv1434518 CNV insertion 17803354
esv1671601 CNV insertion 17803354
esv2658677 CNV deletion 23128226
esv2674260 CNV deletion 23128226
esv2674786 CNV deletion 23128226
esv2713964 CNV deletion 23290073
esv3351950 CNV insertion 20981092
esv3376019 CNV insertion 20981092
esv3418682 CNV insertion 20981092
esv3582009 CNV loss 25503493
esv3637908 CNV loss 21293372
esv3637909 CNV loss 21293372
esv3637910 CNV loss 21293372
esv3637911 CNV loss 21293372
esv3637912 CNV loss 21293372
esv3892791 CNV loss 25118596
esv5815 CNV loss 19470904
nsv1040428 CNV gain 25217958
nsv1051030 CNV loss 25217958
nsv1071263 CNV deletion 25765185
nsv522111 CNV loss 19592680
nsv827550 CNV loss 20364138
nsv833140 CNV loss 17160897
nsv958203 CNV deletion 24416366

Variation tolerance for TEKT5 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT5 Gene

Disorders for TEKT5 Gene

Relevant External Links for TEKT5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TEKT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT5 Gene

Publications for TEKT5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 60
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 60

Products for TEKT5 Gene

Sources for TEKT5 Gene

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