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Set Analyses:

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TEKT5 Gene

protein-coding GIFtS: 46
GCID: GC16M010721

Tektin 5

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tektin 5¹ ²
CT149²
tektin-5²

External Ids:	HGNC: 26554¹	Entrez Gene: 146279²	Ensembl: ENSG00000153060⁷	UniProtKB: Q96M29³

Export aliases for TEKT5 gene to outside databases

Previous GC identifer: GC16M010629

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEKT5 Gene:

TEKT5 (tektin 5) is a protein-coding gene. Diseases associated with TEKT5 include type 1 diabetes, and schizophrenia. An important paralog of this gene is ENSG00000215615.

UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29

Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of

ciliary and flagellar microtubules (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NT_010393.17 NC_018927.2

Regulatory elements:

Regulatory transcription factor binding sites in the TEKT5 gene promoter:
HOXA9B HOXA9 SRF SRF (504 AA) XBP-1 MIF-1 GATA-1 AREB6 Chx10 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEKT5 promoter sequence

Search Chromatin IP Primers for TEKT5

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEKT5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13

TEKT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEKT5 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M010721: view genomic region (about GC identifiers)

Start:	10,721,358 bp from pter	End:	10,788,802 bp from pter
Size:	67,445 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29 (See protein sequence)

Recommended Name: Tektin-5

Size: 485 amino acids; 56294 Da

Secondary accessions: A1L3Z3

Explore the universe of human proteins at neXtProt for TEKT5: NX_Q96M29

Explore proteomics data for TEKT5 at MOPED

See TEKT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653275.1

ENSEMBL proteins:

ENSP00000283025 ENSP00000458802

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR000435 Tektin

Graphical View of Domain Structure for InterPro Entry Q96M29

ProtoNet protein and cluster: Q96M29

1 Blocks protein domain: IPB000435 Tektin signature

UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29

Similarity: Belongs to the tektin family

TEKT5 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TEKT5_HUMAN, Q96M29

Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of

ciliary and flagellar microtubules (By similarity)

Phenotypes:
1 GenomeRNAi human phenotype for TEKT5:

Decreased viability of wild-ty

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TEKT5_HUMAN, Q96M29: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellum

axoneme (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	3
cytosol	2

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0005929	cilium	IEA	--

TEKT5 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

Search GeneGlobe Interaction Network for TEKT5

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--

TEKT5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TEKT5 gene:

NM_144674.1

Unigene Cluster for TEKT5:

Tektin 5

Hs.143519 [show with all ESTs]

Unigene Representative Sequence: AK057433

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000574923 ENST00000283025(uc002czz.1) ENST00000576638

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Additional mRNA sequence:

AK057433.1 BC041081.1 BC130336.1 BC130338.1

3 DOTS entries:

DT.95307260 DT.100744725 DT.92046643

13 AceView cDNA sequences:

NM_144674 AK057433 BX090442 BE728010 BC041081 AI149878 AI024399 BG478710

BP370921 BI828390 BE387950 BE391867 BF373101

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEKT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CGTAAGACCT

About this image

TEKT5 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TEKT5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.143519

Custom PCR Arrays for TEKT5

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TEKT5 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tekt5^{1 , 5}	tektin 5^{1, 5}	82.69(n)¹ 81.88(a)¹		16 (5.58 cM)⁵ 70426¹ NM_001099275.1¹ NP_001092745.1¹ 10357948⁵
chicken (Gallus gallus)	Aves	TEKT5¹	tektin 5	66.53(n) 66.32(a)		416635 XM_414934.3 XP_414934.3
lizard (Anolis carolinensis)	Reptilia	TEKT5⁶	tektin 5	69(a)	1 ↔ 1	GL343592.1(296721-309451)
fruit fly (Drosophila melanogaster)	Insecta	CG32819⁶ CG17450⁶ (see all 3)	--	29(a) 29(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(21488916-21492131) X(21476995-21479947)

ENSEMBL Gene Tree for TEKT5 (if available)
TreeFam Gene Tree for TEKT5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TEKT5 gene

ENSG00000215615² TEKT4² TEKT2² ENSG00000215750² TEKT1² TEKT3²

4 SIMAP similar genes for TEKT5 using alignment to 2 protein entries: TEKT5_HUMAN (see all proteins):

TEKT3 TEKT1 TEKT2 TEKT4

TEKT5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139036324^1,2		--	10720866(+)	`CCGGAA/GGTGGA`	1	--	ds500¹		0	--	--	--	--
rs142228206^1,2	C	--	10720867(+)	`CGGAGA/GTGGAG`	1	--	ds500¹		0	--	--	--	--
rs146372155^1,2	C	--	10720868(+)	`GGAGGC/TGGAGG`	1	--	ds500¹		0	--	--	--	--
rs139666522^1,2	C	--	10720891(+)	`AAGATG/TGCACC`	1	--	ds500¹		0	--	--	--	--
rs142572634^1,2		--	10720952(+)	`ATAAAC/TACTCC`	1	--	ds500¹		0	--	--	--	--
rs150526148^1,2	C	--	10721113(+)	`TGTTCA/GAGGCC`	1	--	ds500¹		0	--	--	--	--
rs139465989^1,2		--	10721186(+)	`CACCAC/TGGTTT`	1	--	ds500¹		0	--	--	--	--
rs7188834^1,2	C,F,A,H	--	10721196(+)	`tacacC/TgtGCC`	1	--	ds500¹		30		NS EA NA WA CSA	2775
rs74669907^1,2	C	--	10721221(+)	`CAGGTA/GATAGA`	1	--	ds500¹		0	--	--	--	--
rs146921924^1,2	C	--	10721224(+)	`GTGAT-/AGAG AGAGA`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TEKT5 (10721358 - 10788802 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TEKT5 (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
esv2713964	CNV	Deletion	23290073
esv2674260	CNV	Deletion	23128226
esv2658677	CNV	Deletion	23128226
esv2674786	CNV	Deletion	23128226
esv1671601	CNV	Insertion	17803354
esv1298043	CNV	Insertion	17803354
esv1434518	CNV	Insertion	17803354
nsv827550	CNV	Loss	20364138
nsv522111	CNV	Loss	19592680
nsv833140	CNV	Loss	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for TEKT5:
About MalaCards

type 1 diabetes schizophrenia

TEKT5 for disorders About GeneDecksing

Genetic Association Database (GAD): TEKT5
Human Genome Epidemiology (HuGE) Navigator: TEKT5 (1 document)

Export disorders for TEKT5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TEKT5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TEKT5)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Genetic variants associated with disordered eating. (PubMed id 23568457)¹ Wade T.D....Martin N.G. (Int J Eat Disord 2013)
Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)¹ Xu B....Karayiorgou M. (Nat. Genet. 2011)
A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)⁴ Paterson A.D....Bull S.B. (Diabetes 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146279	HGNC: 26554	AceView: FLJ32871	Ensembl:ENSG00000153060	euGenes: HUgn146279
ECgene: TEKT5	H-InvDB: TEKT5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TEKT5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TEKT5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TEKT5 gene:
Search GeneIP for patents involving TEKT5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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ThermoFisher Antibodies for TEKT5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT5

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEKT5
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEKT5

LSBio Antibodies in human, mouse, rat for TEKT5

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TEKT5 gene at Home site.

Version: 3.12.142 28 July 2014
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TEKT5 Gene

Tektin 5

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TEKT5 Gene

Tektin 5

Aliasesfor TEKT5 gene

Summariesfor TEKT5 gene

Genomic Viewsfor TEKT5 gene

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TEKT5 Human Recombinant Protein Products:

TEKT5 Antibody Products:

TEKT5 Assay Products:

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Functionfor TEKT5 gene

Localizationfor TEKT5 gene

Pathways & Interactionsfor TEKT5 gene

Drugs & Compoundsfor TEKT5 gene

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Expression for TEKT5 gene

Orthologsfor TEKT5 gene

Paralogsfor TEKT5 gene

Genomic Variantsfor TEKT5 gene

Disorders / Diseasesfor TEKT5 gene

Publicationsfor TEKT5 gene

External Searches for TEKT5 gene

Genome Databases showing TEKT5 gene

Other Databases showing TEKT5 gene

Specialized Databases showing TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

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for TEKT5 gene

Drugs & Compounds
for TEKT5 gene

Transcripts
for TEKT5 gene

Expression
for TEKT5 gene

Orthologs
for TEKT5 gene

Paralogs
for TEKT5 gene

Genomic Variants
for TEKT5 gene

Disorders / Diseases
for TEKT5 gene

Publications
for TEKT5 gene

Intellectual Property
for TEKT5 gene

Products
for TEKT5 gene