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Aliases for TEKT5 Gene

Aliases for TEKT5 Gene

  • Tektin 5 2 3 5
  • CT149 3

External Ids for TEKT5 Gene

Previous GeneCards Identifiers for TEKT5 Gene

  • GC16M010629
  • GC16M010721

Summaries for TEKT5 Gene

GeneCards Summary for TEKT5 Gene

TEKT5 (Tektin 5) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT5 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT5 Gene

Genomics for TEKT5 Gene

Regulatory Elements for TEKT5 Gene

Promoters for TEKT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TEKT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEKT5 Gene

Chromosome:
16
Start:
10,581,369 bp from pter
End:
10,742,416 bp from pter
Size:
161,048 bases
Orientation:
Minus strand

Genomic View for TEKT5 Gene

Genes around TEKT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT5 Gene

Proteins for TEKT5 Gene

  • Protein details for TEKT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M29-TEKT5_HUMAN
    Recommended name:
    Tektin-5
    Protein Accession:
    Q96M29
    Secondary Accessions:
    • A1L3Z3

    Protein attributes for TEKT5 Gene

    Size:
    485 amino acids
    Molecular mass:
    56294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT5 Gene

Proteomics data for TEKT5 Gene at MOPED

Post-translational modifications for TEKT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TEKT5 Gene

Domains & Families for TEKT5 Gene

Gene Families for TEKT5 Gene

Protein Domains for TEKT5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M29

UniProtKB/Swiss-Prot:

TEKT5_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT5: view

Function for TEKT5 Gene

Molecular function for TEKT5 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Phenotypes for TEKT5 Gene

genes like me logo Genes that share phenotypes with TEKT5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT5 Gene

Localization for TEKT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT5 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT5 Gene COMPARTMENTS Subcellular localization image for TEKT5 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TEKT5: view

Pathways & Interactions for TEKT5 Gene

SuperPathways for TEKT5 Gene

No Data Available

Interacting Proteins for TEKT5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283025%0d%0a9606.ENSP00000319756%0d%0a9606.ENSP00000321475%0d%0a
Selected Interacting proteins: Q96M29-TEKT5_HUMAN ENSP00000283025 for TEKT5 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for TEKT5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEKT5 Gene

Drugs & Compounds for TEKT5 Gene

No Compound Related Data Available

Transcripts for TEKT5 Gene

mRNA/cDNA for TEKT5 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEKT5 Gene

Tektin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT5 Gene

No ASD Table

Relevant External Links for TEKT5 Gene

GeneLoc Exon Structure for
TEKT5
ECgene alternative splicing isoforms for
TEKT5

Expression for TEKT5 Gene

mRNA expression in normal human tissues for TEKT5 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT5 Gene

This gene is overexpressed in Testis (x40.0).

Protein differential expression in normal tissues from HIPED for TEKT5 Gene

This gene is overexpressed in Tlymphocyte (42.1) and Testis (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT5 Gene



SOURCE GeneReport for Unigene cluster for TEKT5 Gene Hs.143519

genes like me logo Genes that share expression patterns with TEKT5: view

Protein tissue co-expression partners for TEKT5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TEKT5 Gene

Orthologs for TEKT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEKT5 35
  • 87.54 (n)
  • 85.59 (a)
TEKT5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT5 35
  • 88.73 (n)
  • 88.87 (a)
TEKT5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tekt5 35
  • 82.69 (n)
  • 81.88 (a)
Tekt5 16
Tekt5 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEKT5 35
  • 98.35 (n)
  • 97.73 (a)
TEKT5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt5 35
  • 82.47 (n)
  • 82.89 (a)
oppossum
(Monodelphis domestica)
Mammalia TEKT5 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT5 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT5 35
  • 66.53 (n)
  • 66.32 (a)
TEKT5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT5 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17450 36
  • 29 (a)
ManyToMany
CG32819 36
  • 29 (a)
ManyToMany
CG32820 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for TEKT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEKT5 Gene

ENSEMBL:
Gene Tree for TEKT5 (if available)
TreeFam:
Gene Tree for TEKT5 (if available)

Paralogs for TEKT5 Gene

Paralogs for TEKT5 Gene

(4) SIMAP similar genes for TEKT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TEKT5: view

Variants for TEKT5 Gene

Sequence variations from dbSNP and Humsavar for TEKT5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs16957557 - 10,694,699(+) GTTGG(C/T)TATCT intron-variant, nc-transcript-variant, reference, missense
VAR_053723 -
VAR_053724 -
rs2719710 - 10,676,101(+) GCAGC(C/T)GGATG nc-transcript-variant, reference, missense
rs1074725 -- 10,600,719(+) CTGCC(G/T)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT5 Gene

Variant ID Type Subtype PubMed ID
esv2658677 CNV Deletion 23128226
esv2674260 CNV Deletion 23128226
esv1434518 CNV Insertion 17803354
nsv833140 CNV Loss 17160897
nsv522111 CNV Loss 19592680
nsv827550 CNV Loss 20364138
esv2713964 CNV Deletion 23290073
esv5815 CNV Loss 19470904
esv2674786 CNV Deletion 23128226
esv1298043 CNV Insertion 17803354
esv1671601 CNV Insertion 17803354
nsv905342 CNV Loss 21882294

Variation tolerance for TEKT5 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT5 Gene

HapMap Linkage Disequilibrium report
TEKT5
Human Gene Mutation Database (HGMD)
TEKT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT5 Gene

Disorders for TEKT5 Gene

Relevant External Links for TEKT5

Genetic Association Database (GAD)
TEKT5
Human Genome Epidemiology (HuGE) Navigator
TEKT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT5

No disorders were found for TEKT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT5 Gene

Publications for TEKT5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3

Products for TEKT5 Gene

Sources for TEKT5 Gene

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