TEKT5 Gene

Aliases
for TEKT5 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifer: GC16M010629

Summaries
for TEKT5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TEKT5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NT_010393.17  NC_018927.2  

SwitchGear Promoter luciferase reporter plasmid: TEKT5 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEKT5

TEKT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M010721:  view genomic region     (about GC identifiers)

Proteins
for TEKT5 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TEKT5: NX_Q96M29

Explore proteomics data for TEKT5 at MOPED


See TEKT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

TEKT5 Human Recombinant Protein Products:

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	antibodies-online peptides for TEKT5

TEKT5 Antibody Products:

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TEKT5 Assay Products:

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	antibodies-online kits for TEKT5 (4 products)

Domains /
Families
for TEKT5 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96M29

Find genes that share domains with TEKT5           About GenesLikeMe

Function
for TEKT5 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     1 GenomeRNAi human phenotype for TEKT5:

genOway: Develop your customized and physiologically relevant rodent model for TEKT5

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		Search for qRT-PCR Assays for microRNAs that regulate TEKT5
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		Predesigned siRNA for gene silencing in human, mouse, rat TEKT5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TEKT5

Clone Products:		OriGene clones in human, mouse for TEKT5 (see all 5) OriGene ORF clones in mouse, rat for TEKT5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TEKT5 (NM_144674)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEKT5
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TEKT5
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5

Localization
for TEKT5 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	3
cytosol	2

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for TEKT5 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for TEKT5 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TEKT5 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TEKT5 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TEKT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CGTAAGACCT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TEKT5
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEKT5
		QuantiTect SYBR Green Assays in human, mouse, rat TEKT5
		QuantiFast Probe-based Assays in human, mouse, rat TEKT5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5

Orthologs
for TEKT5 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TEKT5 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TEKT5 gene

ENSG00000215615²  TEKT4²  TEKT2²  ENSG00000215750²  TEKT1²  TEKT3²  

4 SIMAP similar genes for TEKT5 using alignment to 2 protein entries:     TEKT5_HUMAN (see all proteins):

TEKT3    TEKT1    TEKT2    TEKT4

Find genes that share paralogs with TEKT5           About GenesLikeMe

Genomic Variants
for TEKT5 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TEKT5 (see all 2486)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1390363241,2		--	10720866(+)	CCGGAA/GGTGGA	1	--	ds5001		0	--	--	--	--
rs1422282061,2	C	--	10720867(+)	CGGAGA/GTGGAG	1	--	ds5001		0	--	--	--	--
rs1463721551,2	C	--	10720868(+)	GGAGGC/TGGAGG	1	--	ds5001		0	--	--	--	--
rs1396665221,2	C	--	10720891(+)	AAGATG/TGCACC	1	--	ds5001		0	--	--	--	--
rs1425726341,2		--	10720952(+)	ATAAAC/TACTCC	1	--	ds5001		0	--	--	--	--
rs1505261481,2	C	--	10721113(+)	TGTTCA/GAGGCC	1	--	ds5001		0	--	--	--	--
rs1394659891,2		--	10721186(+)	CACCAC/TGGTTT	1	--	ds5001		0	--	--	--	--
rs71888341,2	C,F,A,H	--	10721196(+)	tacacC/TgtGCC	1	--	ds5001		30		NS EA NA WA CSA	2775
rs746699071,2	C	--	10721221(+)	CAGGTA/GATAGA	1	--	ds5001		0	--	--	--	--
rs1469219241,2	C	--	10721224(+)	GTGAT-/AGAG           AGAGA	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for TEKT5 (10721358 - 10788802 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TEKT5 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2713964	CNV	Deletion	23290073
esv2674260	CNV	Deletion	23128226
esv2658677	CNV	Deletion	23128226
esv2674786	CNV	Deletion	23128226
esv1671601	CNV	Insertion	17803354
esv1298043	CNV	Insertion	17803354
esv1434518	CNV	Insertion	17803354
nsv827550	CNV	Loss	20364138
nsv522111	CNV	Loss	19592680
nsv833140	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TEKT5

DNA2.0 Custom Variant and Variant Library Synthesis for TEKT5

Disorders / Diseases
for TEKT5 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TEKT5 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TEKT5 gene integrated from 10 sources: (articles sorted by number of sources associating them with TEKT5)

Utopia: connect your pdf to the dynamic world of online information

1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Genetic variants associated with disordered eating. (PubMed id 23568457)¹ Wade T.D....Martin N.G. (Int J Eat Disord 2013)
4. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)¹ Xu B....Karayiorgou M. (Nat. Genet. 2011)
5. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)⁴ Paterson A.D....Bull S.B. (Diabetes 2010)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for TEKT5 gene

Genome Databases showing TEKT5 gene

Other Databases showing TEKT5 gene

Specialized Databases showing TEKT5 gene

Products
for TEKT5 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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