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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEKT5 Gene

protein-coding   GIFtS: 46
GCID: GC16M010721

Tektin 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tektin 51 2
tektin-52

External Ids:    HGNC: 265541   Entrez Gene: 1462792   Ensembl: ENSG000001530607   UniProtKB: Q96M293   

Export aliases for TEKT5 gene to outside databases

Previous GC identifer: GC16M010629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEKT5 Gene: 
TEKT5 (tektin 5) is a protein-coding gene. Diseases associated with TEKT5 include schizophrenia. An important paralog of this gene is ENSG00000215615.

UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29
Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
ciliary and flagellar microtubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEKT5 gene promoter:
         HOXA9B   HOXA9   SRF   SRF (504 AA)   XBP-1   MIF-1   GATA-1   AREB6   Chx10   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEKT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEKT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

TEKT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEKT5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M010721:  view genomic region     (about GC identifiers)

Start:
10,721,358 bp from pter      End:
10,788,802 bp from pter
Size:
67,445 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29 (See protein sequence)
Recommended Name: Tektin-5  
Size: 485 amino acids; 56294 Da
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellum
axoneme (By similarity)
Secondary accessions: A1L3Z3

Explore the universe of human proteins at neXtProt for TEKT5: NX_Q96M29

Explore proteomics data for TEKT5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96M29

  • TEKT5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEKT5 Protein Expression
    REFSEQ proteins: NP_653275.1  
    ENSEMBL proteins: 
     ENSP00000283025   ENSP00000458802  

    Human Recombinant Protein Products for TEKT5: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0035085cilium axoneme IEA--

    TEKT5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000435 Tektin

    Graphical View of Domain Structure for InterPro Entry Q96M29

    ProtoNet protein and cluster: Q96M29

    1 Blocks protein domain: IPB000435 Tektin signature

    UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29
    Similarity: Belongs to the tektin family


    TEKT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEKT5_HUMAN, Q96M29
    Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
    ciliary and flagellar microtubules (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for TEKT5:

     Decreased viability of wild-ty 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--

    TEKT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEKT5

    Search CenterWatch for drugs/clinical trials and news about TEKT5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for TEKT5 gene: 
    NM_144674.1  

    Unigene Cluster for TEKT5:

    Tektin 5
    Hs.143519  [show with all ESTs]
    Unigene Representative Sequence: AK057433
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574923 ENST00000283025(uc002czz.1) ENST00000576638
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT5

    Additional mRNA sequence: 

    AK057433.1 BC041081.1 BC130336.1 BC130338.1 

    3 DOTS entries:

    DT.95307260  DT.100744725  DT.92046643 

    13 AceView cDNA sequences:

    BC041081 NM_144674 BX090442 BE728010 AK057433 AI024399 BG478710 BP370921 
    BI828390 AI149878 BE387950 BE391867 BF373101 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEKT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTAAGACCT
    TEKT5 Expression
    About this image


    See TEKT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEKT5

    SOURCE GeneReport for Unigene cluster: Hs.143519
        SABiosciences Custom PCR Arrays for TEKT5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TEKT5 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tekt51 , 5 tektin 51, 5 82.69(n)1
    81.88(a)1
      16 (5.58 cM)5
    704261  NM_001099275.11  NP_001092745.11 
     103579485 
    chicken
    (Gallus gallus)
    Aves TEKT51 tektin 5 66.6(n)
    66.53(a)
      416635  XM_414934.2  XP_414934.2 
    lizard
    (Anolis carolinensis)
    Reptilia TEKT56
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343592.1(296721-309451)
    zebrafish
    (Danio rerio)
    Actinopterygii tekt36
    tektin 3
    51(a)
    1 → many
    12(38865946-38880343)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG174506
    CG328206
    (see all 3)
    --
    27(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(21476995-21479947)
    X(21482824-21486039)


    ENSEMBL Gene Tree for TEKT5 (if available)
    TreeFam Gene Tree for TEKT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEKT5 gene
    ENSG000002156152  TEKT42  TEKT22  ENSG000002157502  TEKT12  TEKT32  
    4 SIMAP similar genes for TEKT5 using alignment to 2 protein entries:     TEKT5_HUMAN (see all proteins):
    TEKT3    TEKT1    TEKT2    TEKT4

    TEKT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2486 SNPs in TEKT5 are shown (see all 2486)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390363241,2
    --10720866(+) CCGGAA/GGTGGA 1 -- ds50010--------
    rs1422282061,2
    C--10720867(+) CGGAGA/GTGGAG 1 -- ds50010--------
    rs1463721551,2
    C--10720868(+) GGAGGC/TGGAGG 1 -- ds50010--------
    rs1396665221,2
    C--10720891(+) AAGATG/TGCACC 1 -- ds50010--------
    rs1425726341,2
    --10720952(+) ATAAAC/TACTCC 1 -- ds50010--------
    rs1505261481,2
    C--10721113(+) TGTTCA/GAGGCC 1 -- ds50010--------
    rs1394659891,2
    --10721186(+) CACCAC/TGGTTT 1 -- ds50010--------
    rs71888341,2
    C,F,A,H--10721196(+) tacacC/TgtGCC 1 -- ds500130Minor allele frequency- T:0.47NS EA NA WA CSA 2775
    rs746699071,2
    C--10721221(+) CAGGTA/GATAGA 1 -- ds50010--------
    rs1469219241,2
    C--10721224(+) GTGAT-/AGAG  
            
    AGAGA
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TEKT5 (10721358 - 10788802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TEKT5 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2713964CNV Deletion23290073
    esv2674260CNV Deletion23128226
    esv2658677CNV Deletion23128226
    esv2674786CNV Deletion23128226
    esv1671601CNV Insertion17803354
    esv1298043CNV Insertion17803354
    esv1434518CNV Insertion17803354
    nsv827550CNV Loss20364138
    nsv522111CNV Loss19592680
    nsv833140CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TEKT5:    About MalaCards
    schizophrenia    


    TEKT5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TEKT5
    Human Genome Epidemiology (HuGE) Navigator: TEKT5 (1 document)

    Export disorders for TEKT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEKT5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEKT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)
    4. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
    5. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146279 HGNC: 26554 AceView: FLJ32871 Ensembl:ENSG00000153060 euGenes: HUgn146279
    ECgene: TEKT5 H-InvDB: TEKT5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEKT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEKT5 gene:
    Search GeneIP for patents involving TEKT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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