TEKT5 Gene(Protein Coding)

Tektin 5

GCID:: GC16M010627

GIFtS:: 48

Genes Participants

Aliases for TEKT5 Gene

Tektin 5 ² ³ ⁵
CT149 ³

External Ids for TEKT5 Gene

HGNC: 26554
Entrez Gene: 146279
Ensembl: ENSG00000153060
UniProtKB: Q96M29

Previous GeneCards Identifiers for TEKT5 Gene

GC16M010629
GC16M010721

Export aliases for TEKT5 gene to outside databases

Summaries for TEKT5 Gene

GeneCards Summary for TEKT5 Gene

TEKT5 (Tektin 5) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT5 Gene

TEKT5_HUMAN,Q96M29

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT5 Gene

Genomics for TEKT5 Gene

Regulatory Elements for TEKT5 Gene

Enhancers for TEKT5 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around TEKT5 on UCSC Golden Path with GeneCards custom track

Promoters for TEKT5 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around TEKT5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TEKT5 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for TEKT5 Gene

Chromosome:: 16

Start:: 10,581,369 bp from pter
End:: 10,742,416 bp from pter

Size:: 161,048 bases
Orientation:: Minus strand

Genomic View for TEKT5 Gene

Genes around TEKT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

16p13.13 by Ensembl
16p13.13 by Entrez Gene
16p13.13 by HGNC

TEKT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for TEKT5 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TEKT5 Gene

Proteins for TEKT5 Gene

Protein details for TEKT5 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q96M29-TEKT5_HUMAN

Recommended name:

Tektin-5

Protein Accession:

Q96M29

Secondary Accessions:
- A1L3Z3
Protein attributes for TEKT5 Gene

Size:

485 amino acids

Molecular mass:

56294 Da

Quaternary structure:

No Data Available

neXtProt entry for TEKT5 Gene

Proteomics data for TEKT5 Gene at MOPED

Protein Expression for TEKT5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TEKT5 Gene

Modification sites at PhosphoSitePlus
- Q96M29
Modification sites at neXtProt
- NX_Q96M29

Other Protein References for TEKT5 Gene

ENSEMBL proteins:

REFSEQ proteins:

NP_653275.1

Antibody Products

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies

Browse R&D Systems for Antibodies

OriGene Antibodies for TEKT5
- TA320111
- TA322046
- TA322047
- TA333511
Custom Antibody Services

Novus Biologicals Antibodies for TEKT5

Abcam antibodies for TEKT5

Browse Antibodies at Cloud-Clone Corp.

Invitrogen Antibodies for TEKT5

antibodies-online Antibodies for TEKT5: See all 37

GeneTex TEKT5 antibody for TEKT5

ProSci Antibodies for TEKT5
- TEKT5 Antibody
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for TEKT5
- Tektin 5 (T-20)
- Tektin 5 (S-20)

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

Browse R&D Systems for Human Recombinant Proteins

Browse Enzo Life Sciences for proteins

OriGene Purified Proteins for TEKT5
- NM_144674
- NM_144674
Search Origene for MassSpec and Protein Over-expression Lysates for TEKT5
Origene Custom Protein Services for TEKT5

GenScript Custom Purified and Recombinant Proteins Services for TEKT5

Novus Biologicals proteins and lysates for TEKT5

Browse ProSpec Recombinant Proteins

Browse Proteins at Cloud-Clone Corp.

Search eBioscience for TEKT5 related proteins

antibodies-online Proteins for TEKT5: See all 4
Search antibodies-online for peptides

Search GeneTex for Proteins for TEKT5

Search for Proteins for TEKT5 at Abcam

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for TEKT5

Browse Enzo Life Sciences for kits & assays

Browse Assay Kits at Cloud-Clone Corp.

Search eBioscience for TEKT5 related elisas

Search antibodies-online for kits

Search for Assays for TEKT5 at Abcam

No data available for DME Specific Peptides for TEKT5 Gene

Domains & Families for TEKT5 Gene

Gene Families for TEKT5 Gene

HGNC:

949 : Tektins

Protein Domains for TEKT5 Gene

InterPro:

Tektin

Blocks:

Tektin signature

ProtoNet:

Q96M29

Suggested Antigen Peptide Sequences for TEKT5 Gene

GenScript: Design optimal peptide antigens:

Tektin-5 (TEKT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96M29

UniProtKB/Swiss-Prot:

TEKT5_HUMAN :

Belongs to the tektin family.

Family:

Belongs to the tektin family.

Function for TEKT5 Gene

Molecular function for TEKT5 Gene

UniProtKB/Swiss-Prot Function:

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

TEKT5_HUMAN,Q96M29

Phenotypes for TEKT5 Gene

GenomeRNAi human phenotypes for TEKT5:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT5 Gene

Localization for TEKT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT5 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Q96M29-TEKT5_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for TEKT5 Gene

Compartment	Confidence
nucleus	5
cytoskeleton	4
cytosol	2

Gene Ontology (GO) - Cellular Components for TEKT5 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005929	cilium	IEA	--

Pathways & Interactions for TEKT5 Gene

SuperPathways for TEKT5 Gene

More details on SuperPathways for TEKT5

No Data Available

Interacting Proteins for TEKT5 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283025%0d%0a9606.ENSP00000319756%0d%0a9606.ENSP00000321475%0d%0a — STRING Interaction Network Preview (showing 2 interactants - click image to see details)

Selected Interacting proteins: ENSP00000283025 Q96M29-TEKT5_HUMAN for TEKT5 Gene via STRING UniProtKB

Symbol	External ID(s)	Details
KLHL38	ENSP00000321475 ²⁰ Q2WGJ6 ⁴	STRING: ENSP00000321475 EBI-10239812, EBI-6426443
TNS2	ENSP00000319756 ²⁰ Q63HR2 ⁴	STRING: ENSP00000319756 EBI-10239812, EBI-949753

Gene Ontology (GO) - Biological Process for TEKT5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEKT5 Gene

Drugs & Compounds for TEKT5 Gene

No Compound Related Data Available

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TEKT5

Browse compounds at ApexBio

Transcripts for TEKT5 Gene

mRNA/cDNA for TEKT5 Gene

(9) REFSEQ mRNAs :

(4) Additional mRNA sequences :

(13) Selected AceView cDNA sequences:

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEKT5 Gene

Tektin 5:

Hs.143519

Representative Sequences:

AK057433

CRISPR Products

OriGene CRISPR knockouts for TEKT5
- KN214595
- KN317402

Santa Cruz Biotechnology (SCBT) CRISPR for TEKT5

GenScript: Design CRISPR guide RNA sequences for TEKT5

miRNA Products

Search ViGene Biosciences for TEKT5

Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhibitory RNA Products

Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TEKT5
Browse OriGene Inhibitory RNA Products For TEKT5

ViGene Biosciences ready-to-package AAV shRNAs for TEKT5 gene
- SH838238

Search Santa Cruz Biotechnology (SCBT) for TEKT5 siRNA/shRNA

Clone Products

OriGene clones in human for TEKT5
OriGene ORF clones in human,mouse,rat for TEKT5
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector

Browse Sino Biological cDNA Clones

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for TEKT5

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT5 Gene

No ASD Table

Relevant External Links for TEKT5 Gene

GeneLoc Exon Structure for: TEKT5
ECgene alternative splicing isoforms for: TEKT5

Expression for TEKT5 Gene

mRNA expression in normal human tissues for TEKT5 Gene

mRNA expression by BioGPS for TEKT5 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT5 Gene

This gene is overexpressed in Testis (x40.0).

Protein differential expression in normal tissues from HIPED for TEKT5 Gene

This gene is overexpressed in Tlymphocyte (42.1) and Testis (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEKT5 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for TEKT5 Gene

SOURCE GeneReport for Unigene cluster for TEKT5 Gene Hs.143519

Protein tissue co-expression partners for TEKT5 Gene

- Elite partner

Primer Products

OriGene qPCR primer pairs for TEKT5
- HP217255

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TEKT5 Gene

Orthologs for TEKT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT5 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	TEKT5 ³⁵	87.54 (n) 85.59 (a)		521940 NM_001046259.2 NP_001039724.1
cow (Bos Taurus)	Mammalia	TEKT5 ³⁶	81 (a)	OneToOne	25:9423862-9474899
dog (Canis familiaris)	Mammalia	TEKT5 ³⁵	88.73 (n) 88.87 (a)		479851 XM_536976.4 XP_536976.2
dog (Canis familiaris)	Mammalia	TEKT5 ³⁶	88 (a)	OneToOne	6:31936653-31976074
mouse (Mus musculus)	Mammalia	Tekt5 ³⁵	82.69 (n) 81.88 (a)		70426 NM_001099275.1 NP_001092745.1
		Tekt5 ¹⁶			10357948
		Tekt5 ³⁶	82 (a)	OneToOne	16:10357948-10395490
chimpanzee (Pan troglodytes)	Mammalia	TEKT5 ³⁵	98.35 (n) 97.73 (a)		453911 XM_510810.3 XP_510810.2
chimpanzee (Pan troglodytes)	Mammalia	TEKT5 ³⁶	98 (a)	OneToOne	16:10781772-10854623
rat (Rattus norvegicus)	Mammalia	Tekt5 ³⁵	82.47 (n) 82.89 (a)		363538 NM_001014224.2 NP_001014246.1
oppossum (Monodelphis domestica)	Mammalia	TEKT5 ³⁶	76 (a)	OneToOne	6:110797808-110876900
platypus (Ornithorhynchus anatinus)	Mammalia	TEKT5 ³⁶	64 (a)	OneToOne	2:30218489-30289490
chicken (Gallus gallus)	Aves	TEKT5 ³⁵	66.53 (n) 66.32 (a)		416635 XM_414934.3 XP_414934.3
chicken (Gallus gallus)	Aves	TEKT5 ³⁶	65 (a)	OneToOne	14:9115588-9136174
lizard (Anolis carolinensis)	Reptilia	TEKT5 ³⁶	69 (a)	OneToOne	GL343592.1:296721-309451
fruit fly (Drosophila melanogaster)	Insecta	CG17450 ³⁶	29 (a)	ManyToMany	X:21476995-21479947
		CG32819 ³⁶	29 (a)	ManyToMany	X:21488916-21492131
		CG32820 ³⁶	29 (a)	ManyToMany	X:21482824-21486039
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁶	52 (a)	OneToOne	reftig_31:204843-209463

Species with no ortholog for TEKT5:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
tropical clawed frog (Silurana tropicalis)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)
zebrafish (Danio rerio)

Evolution for TEKT5 Gene

ENSEMBL:: Gene Tree for TEKT5 (if available)
TreeFam:: Gene Tree for TEKT5 (if available)

Paralogs for TEKT5 Gene

(4) SIMAP similar genes for TEKT5 Gene using alignment to 2 proteins:

Variants for TEKT5 Gene

Sequence variations from dbSNP and Humsavar for TEKT5 Gene

SNP ID	Clin	Chr 16 pos	Sequence Context	Type
rs16957557	-	10,694,699(+)	GTTGG(C/T)TATCT	intron-variant, nc-transcript-variant, reference, missense
VAR_053723	-
VAR_053724	-
rs2719710	-	10,676,101(+)	GCAGC(C/T)GGATG	nc-transcript-variant, reference, missense
rs4028384	--	10,723,165(-)	CCTAG(A/T)ATTTG	intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT5 Gene

Variant ID	Type	Subtype	PubMed ID
esv2658677	CNV	Deletion	23128226
esv2674260	CNV	Deletion	23128226
esv1434518	CNV	Insertion	17803354
nsv833140	CNV	Loss	17160897
nsv522111	CNV	Loss	19592680
nsv827550	CNV	Loss	20364138
esv2713964	CNV	Deletion	23290073
esv5815	CNV	Loss	19470904
esv2674786	CNV	Deletion	23128226
esv1298043	CNV	Insertion	17803354
esv1671601	CNV	Insertion	17803354
nsv905342	CNV	Loss	21882294

Variation tolerance for TEKT5 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT5 Gene

Human Gene Mutation Database (HGMD): TEKT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT5 Gene

Disorders for TEKT5 Gene

Relevant External Links for TEKT5

Genetic Association Database (GAD): TEKT5
Human Genome Epidemiology (HuGE) Navigator: TEKT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: TEKT5

No disorders were found for TEKT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT5 Gene

Publications for TEKT5 Gene

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) ³ ⁴⁸ ⁶⁷
A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) ³
Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) ³
Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) ³
Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) ³