TEKT5 Gene
protein-coding GIFtS: 45
GCID: GC16M010721
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tektin 5
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Aliases
for TEKT5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tektin 51 2 | | FLJ328711 | | Tektin-51 |
Export aliases for TEKT5 gene to outside databasesPrevious GC identifer: GC16M010629 |
Summaries
for TEKT5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules (By similarity)
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Genomic Views
for TEKT5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TEKT5 gene promoter:
HOXA9B HOXA9 SRF SRF (504 AA) XBP-1 MIF-1 GATA-1 AREB6 Chx10 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TEKT5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13TEKT5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M010721: view genomic region
(about GC identifiers)
Start:
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10,721,358 bp from pter |
End:
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10,788,802 bp from pter |
Size:
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67,445 bases |
Orientation:
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minus strand |
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Proteins
for TEKT5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29 (See
protein sequence)Recommended Name: Tektin-5 Size: 485 amino acids; 56294 Da
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellumaxoneme (By similarity)
Secondary accessions: A1L3Z3Explore the universe of human proteins at neXtProt for TEKT5: NX_Q96M29
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M29
TEKT5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653275.1
ENSEMBL proteins: ENSP00000283025 ENSP00000458802
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TEKT5 for ontologies About GeneDecksing
TEKT5 Antibody Products:
Assay Products for TEKT5: |
Protein
Domains /
Families
for TEKT5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TEKT5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96M29ProtoNet protein and cluster: Q96M29 1 Blocks protein family: IPB000435 Tektin signature
UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29Similarity: Belongs to the tektin family |
Function
for TEKT5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TEKT5_HUMAN, Q96M29Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TEKT5 (NM_144674) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5 |
1 GenomeRNAi human phenotype for TEKT5:
|
Pathways & Interactions
for TEKT5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000226 | microtubule cytoskeleton organization |
IEA | -- |
TEKT5 for ontologies About GeneDecksing
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Drugs & Compounds
for TEKT5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TEKT5
Search CenterWatch for drugs/clinical trials and news about TEKT5
|
Transcripts
for TEKT5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TEKT5 gene: NM_144674.1 Unigene Cluster for TEKT5: Tektin 5 Hs.143519 [show with all ESTs]Unigene Representative Sequence: AK0574333 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574923 ENST00000283025(uc002czz.1) ENST00000576638
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TEKT5 (NM_144674) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT5 |
Additional cDNA sequence: AK057433.1 BC041081.1 BC130336.1 BC130338.1 3 DOTS entries: DT.95307260 DT.100744725 DT.92046643 13 AceView cDNA sequences: BC041081 BX090442 AK057433 BE728010 NM_144674 AI149878 BG478710 BI828390 AI024399 BP370921 BE387950 BE391867 BF373101
GeneLoc Exon Structure
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Expression
for TEKT5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TEKT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTAAGACCT
About this image
See TEKT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TEKT5
SOURCE GeneReport for Unigene cluster: Hs.143519
SABiosciences Custom PCR Arrays for TEKT5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEKT5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TEKT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEKT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5 |
Orthologs
for TEKT5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TEKT5 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for TEKT5 (if available)
TreeFam Gene Tree for TEKT5 (if available) |
Paralogs
for TEKT5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TEKT5 gene
- ENSG000002156152 TEKT42 TEKT22 ENSG000002157502 TEKT12 TEKT32
4 SIMAP similar genes for TEKT5 using alignment to 2 protein entries: TEKT5_HUMAN (see all proteins):TEKT3 TEKT1 TEKT2 TEKT4
TEKT5 for paralogs About GeneDecksing
|
Genomic Variants
for TEKT5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TEKT5 (10721358 - 10788802 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TEKT5
4 Indels: 61492 77181 87961 77180 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEKT5 |
|
Disorders
/ Diseases
for TEKT5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TEKT5 for disorders About GeneDecksing
1  disease for TEKT5: About MalaCardsschizophrenia
Human Genome Epidemiology (HuGE) Navigator: TEKT5 (1 document)
Export disorders for TEKT5 gene to outside databases
|
Publications
for TEKT5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TEKT5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TEKT5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TEKT5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TEKT5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TEKT5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TEKT5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TEKT5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TEKT5 gene:
Search GeneIP for patents involving TEKT5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TEKT5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TEKT5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEKT5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEKT5 | | | OriGene Protein Over-expression Lysate for TEKT5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TEKT5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TEKT5 | | OriGene Custom Protein Services for TEKT5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEKT5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEKT5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEKT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEKT5 |
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 |  |  |  | |
| | | | Search Tocris compounds for TEKT5 |
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 | | | TEKT5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT5 |
|  |  |  | | | | ThermoFisher Antibodies for TEKT5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT5 |
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