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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEKT4 Gene

protein-coding   GIFtS: 45
GCID: GC02P095537

Tektin 4

  Search for TEKT4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tektin 41 2
tektin-42

External Ids:    HGNC: 310121   Entrez Gene: 1504832   Ensembl: ENSG000001630607   UniProtKB: Q8WW243   

Export aliases for TEKT4 gene to outside databases

Previous GC identifers: GC02P094960 GC02P094900 GC02P089566


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TEKT4 Gene: 
TEKT4 (tektin 4) is a protein-coding gene. An important paralog of this gene is ENSG00000215615.

UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24
Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
ciliary and flagellar microtubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEKT4 gene promoter:
         Bach1   RFX1   p53   NRSF form 1   AP-4   NRSF form 2   POU2F1   POU2F1a   HSF2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEKT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEKT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q11.2

TEKT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEKT4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095537:  view genomic region     (about GC identifiers)

Start:
95,537,178 bp from pter      End:
95,542,574 bp from pter
Size:
5,397 bases      Orientation:
plus strand

1 alternative location:
Chr2+,NW_003571032 309,063-314,399     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24 (See protein sequence)
Recommended Name: Tektin-4  
Size: 435 amino acids; 50649 Da
Subcellular location: Cell projection, cilium, flagellum (By similarity). Cytoplasm, cytoskeleton, flagellum
axoneme (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Found in the abaxial
(convex) surface of outer dense fibers in sperm flagella (By similarity)

Explore the universe of human proteins at neXtProt for TEKT4: NX_Q8WW24

Explore proteomics data for TEKT4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WW24

  • TEKT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TEKT4 Protein Expression
    REFSEQ proteins: NP_653306.1  
    ENSEMBL proteins: 
     ENSP00000295201   ENSP00000407596  

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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for TEKT4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0035085cilium axoneme IEA--

    TEKT4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000435 Tektin

    Graphical View of Domain Structure for InterPro Entry Q8WW24

    ProtoNet protein and cluster: Q8WW24

    1 Blocks protein domain: IPB000435 Tektin signature

    UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24
    Similarity: Belongs to the tektin family


    TEKT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEKT4_HUMAN, Q8WW24
    Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
    ciliary and flagellar microtubules (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for TEKT4:

     Increased cell number in G2M,  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tekt4):
     reproductive system 

    TEKT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tekt4tm1Zuk for TEKT4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TEKT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TEKT4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TEKT4 (Q8WW242, 3 ENSP000002952014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-68108 I2D: score=4 STRING: ENSP00000254043
    MAGEA4P433582, 3, ENSP000002763444MINT-67802 I2D: score=4 STRING: ENSP00000276344
    IKZF3Q9UKT93I2D: score=1 
    PSMC5P621953I2D: score=1 
    SHARPINENSP000003816984STRING: ENSP00000381698
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0030030cell projection organization IEA--

    TEKT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEKT4

    Search CenterWatch for drugs/clinical trials and news about TEKT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEKT4 gene: 
    NM_144705.2  

    Unigene Cluster for TEKT4:

    Tektin 4
    Hs.631517  [show with all ESTs]
    Unigene Representative Sequence: AK097438
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468063(uc010fhr.1) ENST00000295201(uc002stw.1) ENST00000427593

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TEKT4
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TEKT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEKT4
    Clone
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    OriGene ORF clones in mouse, rat for TEKT4
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                         Customized lentivirus expression plasmids for stable overexpression of TEKT4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEKT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT4

    Additional mRNA sequence: 

    AK097438.1 AK296678.1 BC021716.2 

    4 DOTS entries:

    DT.87015880  DT.100811904  DT.100811905  DT.120970589 

    21 AceView cDNA sequences:

    CR596788 BC021716 AI811172 CR606432 CR599791 BX280755 NM_144705 BG718927 
    CA314318 AW132103 AK097438 CA944898 AA626939 BI832036 AI805950 AA705460 
    T85369 AW304428 BI826846 AA729676 AI277469 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEKT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCATCGTA
    TEKT4 Expression
    About this image


    See TEKT4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.631517
        SABiosciences Custom PCR Arrays for TEKT4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TEKT4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TEKT4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tekt41 , 5 tektin 41, 5 78.06(n)1
    77.14(a)1
      17 (12.60 cM)5
    718401  NM_027951.11  NP_082227.11 
     254715905 
    chicken
    (Gallus gallus)
    Aves TEKT41 tektin 4 65.82(n)
    67.9(a)
      416527  XM_414831.3  XP_414831.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    GL343263.1(1826071-1843131)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165452 Xenopus laevis transcribed sequence with weak similarity more 74.41(n)    48054347 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1628481 zgc:162848 60.89(n)
    53.63(a)
      559407  NM_001145690.1  NP_001139162.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tektin-A1 Tektin A 44.17(n)
    30(a)
      34934  NM_078853.3  NP_523577.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R02E12.46
    Protein R02E12.4
    15(a)
    1 → many
    X(4003532-4007634)


    ENSEMBL Gene Tree for TEKT4 (if available)
    TreeFam Gene Tree for TEKT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEKT4 gene
    ENSG000002156152  TEKT22  TEKT52  ENSG000002157502  TEKT12  TEKT32  
    5 SIMAP similar genes for TEKT4 using alignment to 2 protein entries:     TEKT4_HUMAN (see all proteins):
    LOC389833    TEKT3    TEKT1    TEKT5    TEKT2

    TEKT4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for TEKT4
    PGOHUM00000248692 PGOHUM00000238998 PGOHUM00000240298 PGOHUM00000233737


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in TEKT4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359414
    A breast cancer sample4--see VAR_0359412 C S mis40--------
    VAR_0290874
    ----see VAR_0290872 N K mis40--------
    VAR_0290854
    ----see VAR_0290852 T M mis40--------
    VAR_0621514
    ----see VAR_0621512 S G mis40--------
    VAR_0290864
    ----see VAR_0290862 K N mis40--------
    rs719885691,2
    ----89564600(+) CTCTG-/CTCTG 
            
    CCTAA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEKT4 (95537178 - 95542574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TEKT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv511796CNV Loss21212237
    nsv511795CNV Loss21212237
    esv6894CNV Loss19470904
    esv24702CNV Gain19812545
    nsv482052CNV Gain20164927
    nsv10089CNV Gain18304495
    essv23304CNV CNV17122850
    dgv1227e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEKT4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TEKT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. [Expression of TEKT4 protein decreases in the ejaculat ed spermatozoa of idiopathic asthenozoospermic men]. (PubMed id 22774605)1 Wu W.B....Feng X.X. (2012)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. (PubMed id 17244819)9 Roy A....Matzuk M.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150483 HGNC: 31012 AceView: MGC27019 Ensembl:ENSG00000163060 euGenes: HUgn150483
    ECgene: TEKT4 H-InvDB: TEKT4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEKT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEKT4 gene:
    Search GeneIP for patents involving TEKT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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