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Aliases for TEKT4 Gene

Aliases for TEKT4 Gene

  • Tektin 4 2 3 5
  • Tektin-4 3

External Ids for TEKT4 Gene

Previous GeneCards Identifiers for TEKT4 Gene

  • GC02P094960
  • GC02P095537
  • GC02P089566

Summaries for TEKT4 Gene

GeneCards Summary for TEKT4 Gene

TEKT4 (Tektin 4) is a Protein Coding gene. An important paralog of this gene is TEKT3.

UniProtKB/Swiss-Prot for TEKT4 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Additional gene information for TEKT4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT4 Gene

Genomics for TEKT4 Gene

GeneHancer (GH) Regulatory Elements for TEKT4 Gene

Promoters and enhancers for TEKT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I094871 Promoter 0.7 EPDnew 550.8 +3.7 3722 0.1 RFX1 EZH2 PIR50745 TEKT4 PIR62504 PIR46911 GC02M094907 CYP4F32P LOC442028
GH02I095073 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.5 +207.8 207825 4.4 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF143 SP3 REST ZNF592 SSRP1 LOC105373488 KCNIP3 ENSG00000231062 TEKT4 MRPS5
GH02I095115 Enhancer 0.8 ENCODE 4.3 +247.8 247754 0.1 ELF3 FOXA2 ARID4B ZSCAN9 RAD21 SLC30A9 ZNF143 BCLAF1 RUNX3 THAP11 TEKT4 MRPS5 LOC105373488
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEKT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEKT4 gene promoter:

Genomic Locations for TEKT4 Gene

Genomic Locations for TEKT4 Gene
chr2:94,867,767-94,876,829
(GRCh38/hg38)
Size:
9,063 bases
Orientation:
Plus strand
chr2:95,537,178-95,542,574
(GRCh37/hg19)

Genomic View for TEKT4 Gene

Genes around TEKT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT4 Gene

Proteins for TEKT4 Gene

  • Protein details for TEKT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW24-TEKT4_HUMAN
    Recommended name:
    Tektin-4
    Protein Accession:
    Q8WW24

    Protein attributes for TEKT4 Gene

    Size:
    435 amino acids
    Molecular mass:
    50649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT4 Gene

Post-translational modifications for TEKT4 Gene

No Post-translational modifications

Other Protein References for TEKT4 Gene

No data available for DME Specific Peptides for TEKT4 Gene

Domains & Families for TEKT4 Gene

Gene Families for TEKT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WW24

UniProtKB/Swiss-Prot:

TEKT4_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT4: view

Function for TEKT4 Gene

Molecular function for TEKT4 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Gene Ontology (GO) - Molecular Function for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEKT4: view
genes like me logo Genes that share phenotypes with TEKT4: view

Animal Models for TEKT4 Gene

MGI Knock Outs for TEKT4:

Animal Model Products

CRISPR Products

miRNA for TEKT4 Gene

miRTarBase miRNAs that target TEKT4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEKT4 Gene

Localization for TEKT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT4 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TEKT4: view

Pathways & Interactions for TEKT4 Gene

SuperPathways for TEKT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030317 flagellated sperm motility IBA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT4: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT4 Gene

Drugs & Compounds for TEKT4 Gene

(11) Drugs for TEKT4 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2141
Epirubicin Approved Pharma 426
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 3027
Vinblastine Approved Pharma 439
Vinorelbine Approved, Investigational Pharma 396
genes like me logo Genes that share compounds with TEKT4: view

Transcripts for TEKT4 Gene

mRNA/cDNA for TEKT4 Gene

Unigene Clusters for TEKT4 Gene

Tektin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT4 Gene

No ASD Table

Relevant External Links for TEKT4 Gene

GeneLoc Exon Structure for
TEKT4
ECgene alternative splicing isoforms for
TEKT4

Expression for TEKT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT4 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT4 Gene

This gene is overexpressed in Testis (x27.6) and Fallopian Tube (x6.2).

Protein differential expression in normal tissues from HIPED for TEKT4 Gene

This gene is overexpressed in Testis (62.2) and Ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT4 Gene



Protein tissue co-expression partners for TEKT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT4 Gene:

TEKT4

SOURCE GeneReport for Unigene cluster for TEKT4 Gene:

Hs.631517

Evidence on tissue expression from TISSUES for TEKT4 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with TEKT4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT4 Gene

Orthologs for TEKT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT4 33 34
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia TEKT4 33 34
  • 85.76 (n)
dog
(Canis familiaris)
Mammalia LOC490081 33
  • 85.3 (n)
-- 34
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tekt4 33 16 34
  • 78.06 (n)
rat
(Rattus norvegicus)
Mammalia Tekt4 33
  • 77.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves TEKT4 33
  • 65.82 (n)
-- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt4 33
  • 64.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16545 33
zebrafish
(Danio rerio)
Actinopterygii tekt4 33 34
  • 60.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tektin-C 34
  • 26 (a)
ManyToMany
Tektin-A 34
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for TEKT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT4 Gene

ENSEMBL:
Gene Tree for TEKT4 (if available)
TreeFam:
Gene Tree for TEKT4 (if available)

Paralogs for TEKT4 Gene

Paralogs for TEKT4 Gene

(5) SIMAP similar genes for TEKT4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TEKT4 Gene

genes like me logo Genes that share paralogs with TEKT4: view

Variants for TEKT4 Gene

Sequence variations from dbSNP and Humsavar for TEKT4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_035941 A breast cancer sample p.Cys272Ser
rs10165220 -- 94,871,255(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs10174668 -- 94,871,296(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs10180591 -- 94,872,591(+) C/T intron_variant
rs10185133 -- 94,877,043(+) G/A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT4 Gene

Variant ID Type Subtype PubMed ID
dgv4007n100 CNV gain 25217958
esv24702 CNV gain 19812545
esv2759075 CNV gain 17122850
esv3591652 OTHER inversion 21293372
esv3591659 CNV gain 21293372
esv6894 CNV loss 19470904
nsv1001915 CNV gain 25217958
nsv10089 CNV gain 18304495
nsv482052 CNV gain 20164927
nsv511795 CNV loss 21212237
nsv511796 CNV loss 21212237
nsv953476 CNV deletion 24416366
nsv961617 CNV duplication 23825009

Variation tolerance for TEKT4 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.16; 96.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT4 Gene

Human Gene Mutation Database (HGMD)
TEKT4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT4 Gene

Disorders for TEKT4 Gene

Additional Disease Information for TEKT4

No disorders were found for TEKT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT4 Gene

Publications for TEKT4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TEKT4 Gene

Sources for TEKT4 Gene

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