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Aliases for TEKT4 Gene

Aliases for TEKT4 Gene

  • Tektin 4 2 3 5

External Ids for TEKT4 Gene

Previous GeneCards Identifiers for TEKT4 Gene

  • GC02P094960
  • GC02P095537
  • GC02P089566

Summaries for TEKT4 Gene

GeneCards Summary for TEKT4 Gene

TEKT4 (Tektin 4) is a Protein Coding gene. An important paralog of this gene is TEKT5.

UniProtKB/Swiss-Prot for TEKT4 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT4 Gene

Genomics for TEKT4 Gene

Regulatory Elements for TEKT4 Gene

Enhancers for TEKT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TEKT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEKT4 Gene

Chromosome:
2
Start:
94,867,767 bp from pter
End:
94,876,829 bp from pter
Size:
9,063 bases
Orientation:
Plus strand

Genomic View for TEKT4 Gene

Genes around TEKT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT4 Gene

Proteins for TEKT4 Gene

  • Protein details for TEKT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW24-TEKT4_HUMAN
    Recommended name:
    Tektin-4
    Protein Accession:
    Q8WW24

    Protein attributes for TEKT4 Gene

    Size:
    435 amino acids
    Molecular mass:
    50649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT4 Gene

Proteomics data for TEKT4 Gene at MOPED

Post-translational modifications for TEKT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEKT4 Gene

Domains & Families for TEKT4 Gene

Gene Families for TEKT4 Gene

Protein Domains for TEKT4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WW24

UniProtKB/Swiss-Prot:

TEKT4_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT4: view

Function for TEKT4 Gene

Molecular function for TEKT4 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Phenotypes for TEKT4 Gene

genes like me logo Genes that share phenotypes with TEKT4: view

Animal Models for TEKT4 Gene

MGI Knock Outs for TEKT4:

Animal Model Products

miRNA for TEKT4 Gene

miRTarBase miRNAs that target TEKT4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEKT4 Gene

Localization for TEKT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT4 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT4 Gene COMPARTMENTS Subcellular localization image for TEKT4 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TEKT4: view

Pathways & Interactions for TEKT4 Gene

SuperPathways for TEKT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEKT4 Gene

Drugs & Compounds for TEKT4 Gene

(12) Drugs for TEKT4 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1910
Epirubicin Approved Pharma 366
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2655
Vinblastine Approved Pharma 396
Vinorelbine Approved, Investigational Pharma 357
genes like me logo Genes that share compounds with TEKT4: view

Transcripts for TEKT4 Gene

mRNA/cDNA for TEKT4 Gene

Unigene Clusters for TEKT4 Gene

Tektin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT4 Gene

No ASD Table

Relevant External Links for TEKT4 Gene

GeneLoc Exon Structure for
TEKT4
ECgene alternative splicing isoforms for
TEKT4

Expression for TEKT4 Gene

mRNA expression in normal human tissues for TEKT4 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT4 Gene

This gene is overexpressed in Testis (x27.6) and Fallopian Tube (x6.2).

Protein differential expression in normal tissues from HIPED for TEKT4 Gene

This gene is overexpressed in Testis (62.2) and Ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT4 Gene



SOURCE GeneReport for Unigene cluster for TEKT4 Gene Hs.631517

genes like me logo Genes that share expression patterns with TEKT4: view

Protein tissue co-expression partners for TEKT4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TEKT4 Gene

Orthologs for TEKT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEKT4 35
  • 85.76 (n)
  • 83.6 (a)
TEKT4 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC490081 35
  • 85.3 (n)
  • 81.06 (a)
-- 36
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tekt4 35
  • 78.06 (n)
  • 77.14 (a)
Tekt4 16
Tekt4 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TEKT4 35
  • 98.93 (n)
  • 99.08 (a)
TEKT4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt4 35
  • 77.21 (n)
  • 75.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves TEKT4 35
  • 65.82 (n)
  • 67.9 (a)
-- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt4 35
  • 64.2 (n)
  • 61.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16545 35
zebrafish
(Danio rerio)
Actinopterygii tekt4 35
  • 60.89 (n)
  • 53.63 (a)
tekt4 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tektin-A 36
  • 22 (a)
ManyToMany
Tektin-C 36
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for TEKT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT4 Gene

ENSEMBL:
Gene Tree for TEKT4 (if available)
TreeFam:
Gene Tree for TEKT4 (if available)

Paralogs for TEKT4 Gene

Paralogs for TEKT4 Gene

(5) SIMAP similar genes for TEKT4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TEKT4 Gene

genes like me logo Genes that share paralogs with TEKT4: view

Variants for TEKT4 Gene

Sequence variations from dbSNP and Humsavar for TEKT4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_029085 -
VAR_029086 -
VAR_029087 -
VAR_035941 A breast cancer sample
VAR_062151 -

Structural Variations from Database of Genomic Variants (DGV) for TEKT4 Gene

Variant ID Type Subtype PubMed ID
essv23304 CNV CNV 17122850
dgv1227e1 CNV Complex 17122850
esv24702 CNV Gain 19812545
nsv511795 CNV Loss 21212237
nsv10089 CNV Gain 18304495
nsv511796 CNV Loss 21212237
esv6894 CNV Loss 19470904
nsv482052 CNV Gain 20164927

Variation tolerance for TEKT4 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.16; 96.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT4 Gene

HapMap Linkage Disequilibrium report
TEKT4
Human Gene Mutation Database (HGMD)
TEKT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT4 Gene

Disorders for TEKT4 Gene

Relevant External Links for TEKT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT4

No disorders were found for TEKT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT4 Gene

Publications for TEKT4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Enriched variations in TEKT4 and breast cancer resistance to paclitaxel. (PMID: 24823476) Jiang Y.Z. … Shao Z.M. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. [Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men]. (PMID: 22774605) Wu W.B. … Feng X.X. (Zhonghua Nan Ke Xue 2012) 3

Products for TEKT4 Gene

Sources for TEKT4 Gene

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