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Aliases for TEKT4 Gene

Aliases for TEKT4 Gene

  • Tektin 4 2 3
  • Tektin-4 3

External Ids for TEKT4 Gene

Summaries for TEKT4 Gene

GeneCards Summary for TEKT4 Gene

TEKT4 (Tektin 4) is a Protein Coding gene. Diseases associated with TEKT4 include colorectal cancer. An important paralog of this gene is TEKT5.

UniProtKB/Swiss-Prot for TEKT4 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT4 Gene

Genomics for TEKT4 Gene

Genomic Location for TEKT4 Gene

Start:
94,871,433 bp from pter
End:
94,876,829 bp from pter
Size:
5,397 bases
Orientation:
Plus strand

Genomic View for TEKT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEKT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT4 Gene

Regulatory Elements for TEKT4 Gene

Proteins for TEKT4 Gene

  • Protein details for TEKT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW24-TEKT4_HUMAN
    Recommended name:
    Tektin-4
    Protein Accession:
    Q8WW24
    Secondary Accessions:

    Protein attributes for TEKT4 Gene

    Size:
    435 amino acids
    Molecular mass:
    50649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT4 Gene

Proteomics data for TEKT4 Gene at MOPED

Post-translational modifications for TEKT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEKT4 Gene

Domains for TEKT4 Gene

Protein Domains for TEKT4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TEKT4_HUMAN
Family:
  • Belongs to the tektin family.:
    • Q8WW24
genes like me logo Genes that share domains with TEKT4: view

No data available for Gene Families for TEKT4 Gene

Function for TEKT4 Gene

Molecular function for TEKT4 Gene

UniProtKB/Swiss-Prot Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Gene Ontology (GO) - Molecular Function for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT4: view

Phenotypes for TEKT4 Gene

MGI mutant phenotypes for TEKT4:
inferred from 1 alleles
GenomeRNAi human phenotypes for TEKT4:
genes like me logo Genes that share phenotypes with TEKT4: view

Animal Models for TEKT4 Gene

MGI Knock Outs for TEKT4:

miRNA for TEKT4 Gene

miRTarBase miRNAs that target TEKT4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TEKT4 Gene

Localization for TEKT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT4 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT4 Gene COMPARTMENTS Subcellular localization image for TEKT4 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TEKT4: view

Pathways for TEKT4 Gene

SuperPathways for TEKT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with TEKT4: view

No data available for Pathways by source for TEKT4 Gene

Transcripts for TEKT4 Gene

mRNA/cDNA for TEKT4 Gene

Unigene Clusters for TEKT4 Gene

Tektin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT4 Gene

No ASD Table

Relevant External Links for TEKT4 Gene

GeneLoc Exon Structure for
TEKT4
ECgene alternative splicing isoforms for
TEKT4

Expression for TEKT4 Gene

mRNA expression in normal human tissues for TEKT4 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT4 Gene

This gene is overexpressed in Testis (27.6) and Fallopian Tube (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEKT4 Gene

SOURCE GeneReport for Unigene cluster for TEKT4 Gene Hs.631517

genes like me logo Genes that share expressions with TEKT4: view

Orthologs for TEKT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT4 36
  • 98.93 (n)
  • 99.08 (a)
TEKT4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT4 36
  • 85.76 (n)
  • 83.6 (a)
TEKT4 37
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 68 (a)
OneToMany
LOC490081 36
  • 85.3 (n)
  • 81.06 (a)
mouse
(Mus musculus)
Mammalia Tekt4 36
  • 78.06 (n)
  • 77.14 (a)
Tekt4 16
Tekt4 37
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tekt4 36
  • 77.21 (n)
  • 75.98 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 64 (a)
OneToMany
TEKT4 36
  • 65.82 (n)
  • 67.9 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 68 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16545 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt4 36
  • 64.2 (n)
  • 61.2 (a)
zebrafish
(Danio rerio)
Actinopterygii tekt4 36
  • 60.89 (n)
  • 53.63 (a)
tekt4 37
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tektin-A 37
  • 22 (a)
ManyToMany
Tektin-C 37
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 37
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for TEKT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT4 Gene

ENSEMBL:
Gene Tree for TEKT4 (if available)
TreeFam:
Gene Tree for TEKT4 (if available)

Paralogs for TEKT4 Gene

Paralogs for TEKT4 Gene

Selected SIMAP similar genes for TEKT4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TEKT4 Gene

genes like me logo Genes that share paralogs with TEKT4: view

Variants for TEKT4 Gene

Sequence variations from dbSNP and Humsavar for TEKT4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_029085 -
VAR_029086 -
VAR_029087 -
VAR_035941 A breast cancer sample
VAR_062151 -

Structural Variations from Database of Genomic Variants (DGV) for TEKT4 Gene

Variant ID Type Subtype PubMed ID
essv23304 CNV CNV 17122850
dgv1227e1 CNV Complex 17122850
esv24702 CNV Gain 19812545
nsv511795 CNV Loss 21212237
nsv10089 CNV Gain 18304495
nsv511796 CNV Loss 21212237
esv6894 CNV Loss 19470904
nsv482052 CNV Gain 20164927

Relevant External Links for TEKT4 Gene

HapMap Linkage Disequilibrium report
TEKT4
Human Gene Mutation Database (HGMD)
TEKT4

Disorders for TEKT4 Gene

(1) MalaCards Diseases for TEKT4 Gene

Search for TEKT4 Gene in MalaCards »
genes like me logo Genes that share disorders with TEKT4: view

No data available for UniProtKB/Swiss-Prot for TEKT4 Gene

Publications for TEKT4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for TEKT4 Gene

Sources for TEKT4 Gene

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