TEKT4 Gene
protein-coding GIFtS: 45
GCID: GC02P095537
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tektin 4
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Aliases
for TEKT4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tektin 41 2 | | MGC270191 | | Tektin-41 |
Export aliases for TEKT4 gene to outside databasesPrevious GC identifers: GC02P094960 GC02P094900 GC02P089566 |
Summaries
for TEKT4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules (By similarity)
|
Genomic Views
for TEKT4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TEKT4 gene promoter:
Bach1 RFX1 p53 NRSF form 1 AP-4 NRSF form 2 POU2F1 POU2F1a HSF2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TEKT4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.1 Ensembl cytogenetic band: 2q11.1 HGNC cytogenetic band: 2q11.2TEKT4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P095537: view genomic region
(about GC identifiers)
Start:
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95,537,178 bp from pter |
End:
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95,542,574 bp from pter |
Size:
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5,397 bases |
Orientation:
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plus strand |
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Proteins
for TEKT4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24 (See
protein sequence)Recommended Name: Tektin-4 Size: 435 amino acids; 50649 Da
Subcellular location: Cell projection, cilium, flagellum (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme(By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Found in the abaxial (convex) surfaceof outer dense fibers in sperm flagella (By similarity)Explore the universe of human proteins at neXtProt for TEKT4: NX_Q8WW24
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WW24
TEKT4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653306.1
ENSEMBL proteins: ENSP00000295201 ENSP00000407596
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TEKT4 for ontologies About GeneDecksing
TEKT4 Antibody Products:
Assay Products for TEKT4: |
Protein
Domains /
Families
for TEKT4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TEKT4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WW24ProtoNet protein and cluster: Q8WW24 1 Blocks protein family: IPB000435 Tektin signature
UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24Similarity: Belongs to the tektin family |
Function
for TEKT4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TEKT4_HUMAN, Q8WW24Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TEKT4 (NM_144705) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT4 |
1 GenomeRNAi human phenotype for TEKT4:
Animal Models:
Mouse knock-out Tekt4tm1Zuk for TEKT4
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tekt4):
TEKT4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TEKT4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for TEKT4 (Q8WW242, 3 ENSP000002952014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000226 | microtubule cytoskeleton organization |
IEA | -- | | GO:0030030 | cell projection organization |
IEA | -- |
TEKT4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TEKT4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TEKT4
Search CenterWatch for drugs/clinical trials and news about TEKT4
|
Transcripts
for TEKT4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TEKT4 gene: NM_144705.2 Unigene Cluster for TEKT4: Tektin 4 Hs.631517 [show with all ESTs]Unigene Representative Sequence: AK0974383 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468063(uc010fhr.1) ENST00000295201(uc002stw.1) ENST00000427593
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TEKT4 (NM_144705) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT4 |
Additional cDNA sequence: AK097438.1 AK296678.1 BC021716.2 4 DOTS entries: DT.87015880 DT.100811904 DT.100811905 DT.120970589 21 AceView cDNA sequences: AI811172 BC021716 BX280755 NM_144705 CR599791 CR606432 CR596788 CA944898 AK097438 AW132103 BI832036 CA314318 AA626939 BG718927 AI805950 AA705460 T85369 AW304428 AA729676 BI826846 AI277469
GeneLoc Exon Structure
|
Expression
for TEKT4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TEKT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCATCGTA
About this image
See TEKT4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.631517
SABiosciences Custom PCR Arrays for TEKT4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEKT4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TEKT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEKT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT4 |
Orthologs
for TEKT4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TEKT4 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for TEKT4 (if available)
TreeFam Gene Tree for TEKT4 (if available) |
Paralogs
for TEKT4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TEKT4 gene
- ENSG000002156152 TEKT52 TEKT22 ENSG000002157502 TEKT12 TEKT32
5 SIMAP similar genes for TEKT4 using alignment to 2 protein entries: TEKT4_HUMAN (see all proteins):LOC389833 TEKT3 TEKT1 TEKT5 TEKT2
TEKT4 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for TEKT4
PGOHUM00000248692 PGOHUM00000238998 PGOHUM00000240298 PGOHUM00000233737
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Genomic Variants
for TEKT4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TEKT4 (95537178 - 95542574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TEKT4
7 CNVs: 61797 74158 2401 30978 74161 3376 74160 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEKT4 |
|
Disorders
/ Diseases
for TEKT4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TEKT4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TEKT4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TEKT4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [Expression of TEKT4 protein decreases in the ejaculat ed spermatozoa of idiopathic asthenozoospermic men]. (PubMed id 22774605)1 Wu W.B....Feng X.X. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. (PubMed id 17244819)9 Roy A....Matzuk M.M. (2007)
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External Searches for TEKT4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TEKT4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TEKT4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TEKT4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TEKT4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TEKT4 gene:
Search GeneIP for patents involving TEKT4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TEKT4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TEKT4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEKT4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TEKT4 | | | OriGene Protein Over-expression Lysate for TEKT4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TEKT4 | | OriGene 3'-UTR Clone for TEKT4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEKT4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEKT4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEKT4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEKT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEKT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEKT4 |
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 |  |  |  | |
| | | | Search Tocris compounds for TEKT4 |
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 | | | TEKT4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT4 |
|  |  |  | | | | ThermoFisher Antibodies for TEKT4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT4 |
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