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Aliases for TEKT3 Gene

Aliases for TEKT3 Gene

  • Tektin 3 2 3

External Ids for TEKT3 Gene

Previous GeneCards Identifiers for TEKT3 Gene

  • GC17M015573
  • GC17M016322
  • GC17M015150
  • GC17M015407
  • GC17M015147
  • GC17M015207
  • GC17M015100

Summaries for TEKT3 Gene

Entrez Gene Summary for TEKT3 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT3 Gene

TEKT3 (Tektin 3) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT3 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT3 Gene

Genomics for TEKT3 Gene

Regulatory Elements for TEKT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TEKT3 Gene

Chromosome:
17
Start:
15,303,811 bp from pter
End:
15,341,889 bp from pter
Size:
38,079 bases
Orientation:
Minus strand

Genomic View for TEKT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT3 Gene

Proteins for TEKT3 Gene

  • Protein details for TEKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXF9-TEKT3_HUMAN
    Recommended name:
    Tektin-3
    Protein Accession:
    Q9BXF9
    Secondary Accessions:
    • B2RAS7
    • D3DTT0
    • Q8N5R5
    • Q96M48

    Protein attributes for TEKT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    56636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT3 Gene

Proteomics data for TEKT3 Gene at MOPED

Post-translational modifications for TEKT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT3 Gene

No data available for DME Specific Peptides for TEKT3 Gene

Domains & Families for TEKT3 Gene

Gene Families for TEKT3 Gene

Protein Domains for TEKT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXF9

UniProtKB/Swiss-Prot:

TEKT3_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT3: view

Function for TEKT3 Gene

Molecular function for TEKT3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

Gene Ontology (GO) - Molecular Function for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT3: view

Phenotypes for TEKT3 Gene

genes like me logo Genes that share phenotypes with TEKT3: view

Animal Models for TEKT3 Gene

MGI Knock Outs for TEKT3:

Animal Model Products

miRNA for TEKT3 Gene

miRTarBase miRNAs that target TEKT3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TEKT3 Gene

Localization for TEKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT3 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT3 Gene COMPARTMENTS Subcellular localization image for TEKT3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005874 microtubule IEA --
GO:0036126 sperm flagellum ISS --
genes like me logo Genes that share ontologies with TEKT3: view

Pathways & Interactions for TEKT3 Gene

SuperPathways for TEKT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 sperm motility ISS --
GO:0060271 cilium morphogenesis ISS --
GO:0080154 regulation of fertilization ISS --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT3 Gene

Drugs & Compounds for TEKT3 Gene

No Compound Related Data Available

Transcripts for TEKT3 Gene

Unigene Clusters for TEKT3 Gene

Tektin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for TEKT3 Gene

GeneLoc Exon Structure for
TEKT3
ECgene alternative splicing isoforms for
TEKT3

Expression for TEKT3 Gene

mRNA expression in normal human tissues for TEKT3 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT3 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for TEKT3 Gene

This gene is overexpressed in Plasma (55.8) and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT3 Gene



SOURCE GeneReport for Unigene cluster for TEKT3 Gene Hs.414648

genes like me logo Genes that share expression patterns with TEKT3: view

Protein tissue co-expression partners for TEKT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TEKT3 Gene

Orthologs for TEKT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEKT3 35
  • 87.62 (n)
  • 91.84 (a)
TEKT3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT3 35
  • 89.73 (n)
  • 91.43 (a)
TEKT3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tekt3 35
  • 83.47 (n)
  • 83.47 (a)
Tekt3 16
Tekt3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEKT3 35
  • 99.52 (n)
  • 98.98 (a)
TEKT3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt3 35
  • 82.79 (n)
  • 83.47 (a)
oppossum
(Monodelphis domestica)
Mammalia TEKT3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT3 35
  • 73.01 (n)
  • 78.12 (a)
TEKT3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15141 35
tekt3 35
  • 67.76 (n)
  • 70.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68964 35
zebrafish
(Danio rerio)
Actinopterygii tekt3 35
  • 62.77 (n)
  • 64.07 (a)
wufc88h09 35
tekt3 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17450 37
  • 27 (a)
Tektin-A 37
  • 30 (a)
Tektin-C 37
  • 26 (a)
CG17450 35
  • 50.58 (n)
  • 40.18 (a)
CG17450 36
  • 30 (a)
ManyToMany
CG32819 36
  • 30 (a)
ManyToMany
CG32820 36
  • 30 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000219 35
  • 52.92 (n)
  • 44.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1706 35
Species with no ortholog for TEKT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT3 Gene

ENSEMBL:
Gene Tree for TEKT3 (if available)
TreeFam:
Gene Tree for TEKT3 (if available)

Paralogs for TEKT3 Gene

Paralogs for TEKT3 Gene

(4) SIMAP similar genes for TEKT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEKT3: view

Variants for TEKT3 Gene

Sequence variations from dbSNP and Humsavar for TEKT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs190159 -- 15,321,264(-) TGGGA(A/G)GCCGA intron-variant
rs230887 -- 15,321,170(-) TAGCC(A/G)GGCAT intron-variant
rs230888 -- 15,320,554(-) AGGTG(A/C)GTAAT intron-variant
rs230889 -- 15,320,165(-) TCACA(C/T)TGGTG intron-variant
rs230890 -- 15,318,565(-) AGAGA(C/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT3 Gene

Variant ID Type Subtype PubMed ID
nsv907703 CNV Gain 21882294

Variation tolerance for TEKT3 Gene

Residual Variation Intolerance Score: 83.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.82; 93.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT3 Gene

HapMap Linkage Disequilibrium report
TEKT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT3 Gene

Disorders for TEKT3 Gene

Relevant External Links for TEKT3

Genetic Association Database (GAD)
TEKT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT3
genes like me logo Genes that share disorders with TEKT3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT3 Gene

Publications for TEKT3 Gene

  1. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. (PMID: 14735490) Roy A. … Matzuk M.M. (Mol. Reprod. Dev. 2004) 2 23 67
  2. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K. … Birren B. (Genome Res. 2001) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 67
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 67

Products for TEKT3 Gene

Sources for TEKT3 Gene

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