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Aliases for TEKT3 Gene

Aliases for TEKT3 Gene

  • Tektin 3 2 3
  • Testicular Microtubules-Related Protein 3
  • Tektin-3 3

External Ids for TEKT3 Gene

Summaries for TEKT3 Gene

Entrez Gene Summary for TEKT3 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT3 Gene

TEKT3 (Tektin 3) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT3 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT3 Gene

Genomics for TEKT3 Gene

Genomic Location for TEKT3 Gene

Start:
15,303,811 bp from pter
End:
15,341,641 bp from pter
Size:
37,831 bases
Orientation:
Minus strand

Genomic View for TEKT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT3 Gene

Regulatory Elements for TEKT3 Gene

Proteins for TEKT3 Gene

  • Protein details for TEKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXF9-TEKT3_HUMAN
    Recommended name:
    Tektin-3
    Protein Accession:
    Q9BXF9
    Secondary Accessions:
    • B2RAS7
    • D3DTT0
    • Q8N5R5
    • Q96M48

    Protein attributes for TEKT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    56636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT3 Gene

Proteomics data for TEKT3 Gene at MOPED

Post-translational modifications for TEKT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT3 Gene

No data available for DME Specific Peptides for TEKT3 Gene

Domains for TEKT3 Gene

Protein Domains for TEKT3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TEKT3_HUMAN
Family:
  • Belongs to the tektin family.:
    • Q9BXF9
genes like me logo Genes that share domains with TEKT3: view

No data available for Gene Families for TEKT3 Gene

Function for TEKT3 Gene

Molecular function for TEKT3 Gene

UniProtKB/Swiss-Prot Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

Gene Ontology (GO) - Molecular Function for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT3: view

Phenotypes for TEKT3 Gene

MGI mutant phenotypes for TEKT3:
inferred from 1 alleles
GenomeRNAi human phenotypes for TEKT3:
genes like me logo Genes that share phenotypes with TEKT3: view

Animal Models for TEKT3 Gene

MGI Knock Outs for TEKT3:

miRNA for TEKT3 Gene

miRTarBase miRNAs that target TEKT3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TEKT3 Gene

Localization for TEKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT3 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT3 Gene COMPARTMENTS Subcellular localization image for TEKT3 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005874 microtubule IEA --
GO:0036126 sperm flagellum ISS --
genes like me logo Genes that share ontologies with TEKT3: view

Pathways for TEKT3 Gene

SuperPathways for TEKT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 sperm motility ISS --
GO:0060271 cilium morphogenesis ISS --
GO:0080154 regulation of fertilization ISS --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Pathways by source for TEKT3 Gene

Transcripts for TEKT3 Gene

Unigene Clusters for TEKT3 Gene

Tektin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for TEKT3 Gene

GeneLoc Exon Structure for
TEKT3
ECgene alternative splicing isoforms for
TEKT3

Expression for TEKT3 Gene

mRNA expression in normal human tissues for TEKT3 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT3 Gene

This gene is overexpressed in Testis (26.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEKT3 Gene

SOURCE GeneReport for Unigene cluster for TEKT3 Gene Hs.414648

genes like me logo Genes that share expressions with TEKT3: view

Orthologs for TEKT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT3 36
  • 99.52 (n)
  • 98.98 (a)
TEKT3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT3 36
  • 87.62 (n)
  • 91.84 (a)
TEKT3 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT3 36
  • 89.73 (n)
  • 91.43 (a)
TEKT3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tekt3 36
  • 83.47 (n)
  • 83.47 (a)
Tekt3 16
Tekt3 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEKT3 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT3 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt3 36
  • 82.79 (n)
  • 83.47 (a)
chicken
(Gallus gallus)
Aves TEKT3 36
  • 73.01 (n)
  • 78.12 (a)
TEKT3 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT3 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68964 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15141 36
tekt3 36
  • 67.76 (n)
  • 70.82 (a)
zebrafish
(Danio rerio)
Actinopterygii tekt3 36
  • 62.77 (n)
  • 64.07 (a)
tekt3 37
  • 64 (a)
OneToOne
wufc88h09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000219 36
  • 52.92 (n)
  • 44.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17450 36
  • 50.58 (n)
  • 40.18 (a)
CG17450 37
  • 30 (a)
ManyToMany
CG32819 37
  • 30 (a)
ManyToMany
CG32820 37
  • 30 (a)
ManyToMany
Tektin-C 38
  • 26 (a)
CG17450 38
  • 27 (a)
Tektin-A 38
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1706 36
Species with no ortholog for TEKT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT3 Gene

ENSEMBL:
Gene Tree for TEKT3 (if available)
TreeFam:
Gene Tree for TEKT3 (if available)

Paralogs for TEKT3 Gene

Paralogs for TEKT3 Gene

Selected SIMAP similar genes for TEKT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEKT3: view

Variants for TEKT3 Gene

Sequence variations from dbSNP and Humsavar for TEKT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13961 -- 15,304,047(-) GCCAC(A/C)CTCGA reference, synonymous-codon
rs190159 -- 15,321,264(-) TGGGA(A/G)GCCGA intron-variant
rs230887 -- 15,321,170(-) TAGCC(A/G)GGCAT intron-variant
rs230888 -- 15,320,554(-) AGGTG(A/C)GTAAT intron-variant
rs230889 -- 15,320,165(-) TCACA(C/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT3 Gene

Variant ID Type Subtype PubMed ID
nsv907703 CNV Gain 21882294

Relevant External Links for TEKT3 Gene

HapMap Linkage Disequilibrium report
TEKT3

Disorders for TEKT3 Gene

(1) University of Copenhagen DISEASES for TEKT3 Gene

Relevant External Links for TEKT3

Genetic Association Database (GAD)
TEKT3
genes like me logo Genes that share disorders with TEKT3: view

No data available for UniProtKB/Swiss-Prot for TEKT3 Gene

Publications for TEKT3 Gene

  1. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. (PMID: 14735490) Roy A. … Matzuk M.M. (Mol. Reprod. Dev. 2004) 2 3 23
  2. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K. … Birren B. (Genome Res. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for TEKT3 Gene

Sources for TEKT3 Gene

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