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Aliases for TEKT3 Gene

Aliases for TEKT3 Gene

  • Tektin 3 2 3 5
  • Testicular Microtubules-Related Protein 3
  • Tektin-3 3

External Ids for TEKT3 Gene

Previous GeneCards Identifiers for TEKT3 Gene

  • GC17M015573
  • GC17M016322
  • GC17M015150
  • GC17M015407
  • GC17M015147
  • GC17M015207
  • GC17M015100

Summaries for TEKT3 Gene

Entrez Gene Summary for TEKT3 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT3 Gene

TEKT3 (Tektin 3) is a Protein Coding gene. Diseases associated with TEKT3 include Charcot-Marie-Tooth Disease, Type 1E. An important paralog of this gene is TEKT5.

UniProtKB/Swiss-Prot for TEKT3 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

Additional gene information for TEKT3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT3 Gene

Genomics for TEKT3 Gene

Regulatory Elements for TEKT3 Gene

Enhancers for TEKT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H015289 1.1 Ensembl ENCODE 19.2 +52.1 52051 1 TBP FOXA2 NFIB JUN ZNF133 CHD4 SIN3A CEBPG YY1 RFX5 NCOR1 TEKT3 ENSG00000266538 PIGL PPIAP53 RNU6-799P ZNF286A TTC19 RPS18P12 TVP23C
GH17H015305 0.8 Ensembl ENCODE 22.1 +35.0 35021 3 HLF CEBPG MAFK GABPA TEKT3 GC17P015309 GC17M015300 PIR38288
GH17H015429 1.4 Ensembl ENCODE dbSUPER 11.2 -92.9 -92925 9 FOXA2 ARID4B DMAP1 YY1 FOS REST PPARG ZNF518A KAT8 NFIL3 CDRT4 TEKT3 RNU6-799P PPIAP53 GC17M015428 RPL9P2
GH17H016212 1.4 Ensembl ENCODE 10.6 -873.6 -873639 5 MLX DMAP1 YY1 ZNF143 SP3 ZC3H11A ZFP41 MEF2D SSRP1 GLIS1 ZSWIM7 PIGL MPRIP-AS1 PPIAP53 UPF3AP1 ZNF286A TVP23C ENSG00000266538 LRRC75A-AS1 TEKT3
GH17H015272 1.2 Ensembl ENCODE dbSUPER 8.7 +68.5 68498 2 ESRRA SIN3A FOSL1 CTBP1 FOS NR2F6 NFE2 MAFK MAFG USF2 TEKT3 ENSG00000230971 GC17M015273
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEKT3 on UCSC Golden Path with GeneCards custom track

Promoters for TEKT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091611 388 600 PKNOX1 ATF1 KLF17 SIN3A BMI1 RFX5 GLIS2 CREM SP3 ZEB2

Genomic Location for TEKT3 Gene

Chromosome:
17
Start:
15,303,811 bp from pter
End:
15,341,889 bp from pter
Size:
38,079 bases
Orientation:
Minus strand

Genomic View for TEKT3 Gene

Genes around TEKT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT3 Gene

Proteins for TEKT3 Gene

  • Protein details for TEKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXF9-TEKT3_HUMAN
    Recommended name:
    Tektin-3
    Protein Accession:
    Q9BXF9
    Secondary Accessions:
    • B2RAS7
    • D3DTT0
    • Q8N5R5
    • Q96M48

    Protein attributes for TEKT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    56636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT3 Gene

Post-translational modifications for TEKT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEKT3 Gene

Domains & Families for TEKT3 Gene

Gene Families for TEKT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXF9

UniProtKB/Swiss-Prot:

TEKT3_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT3: view

Function for TEKT3 Gene

Molecular function for TEKT3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

Phenotypes From GWAS Catalog for TEKT3 Gene

Gene Ontology (GO) - Molecular Function for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT3: view
genes like me logo Genes that share phenotypes with TEKT3: view

Animal Models for TEKT3 Gene

MGI Knock Outs for TEKT3:

Animal Model Products

CRISPR Products

miRNA for TEKT3 Gene

miRTarBase miRNAs that target TEKT3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEKT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEKT3 Gene

Localization for TEKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT3 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEKT3 Gene

Pathways & Interactions for TEKT3 Gene

SuperPathways for TEKT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility ISS,IBA --
GO:0060271 cilium assembly ISS,IBA --
GO:0060294 cilium movement involved in cell motility IBA --
GO:0080154 regulation of fertilization ISS --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT3 Gene

Drugs & Compounds for TEKT3 Gene

No Compound Related Data Available

Transcripts for TEKT3 Gene

Unigene Clusters for TEKT3 Gene

Tektin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TEKT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for TEKT3 Gene

GeneLoc Exon Structure for
TEKT3
ECgene alternative splicing isoforms for
TEKT3

Expression for TEKT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT3 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT3 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for TEKT3 Gene

This gene is overexpressed in Plasma (55.8) and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT3 Gene



Protein tissue co-expression partners for TEKT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT3 Gene:

TEKT3

SOURCE GeneReport for Unigene cluster for TEKT3 Gene:

Hs.414648

Evidence on tissue expression from TISSUES for TEKT3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT3 Gene

Orthologs for TEKT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT3 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TEKT3 33 34
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia TEKT3 33 34
  • 87.62 (n)
mouse
(Mus musculus)
Mammalia Tekt3 33 16 34
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Tekt3 33
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia TEKT3 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT3 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT3 33 34
  • 73.01 (n)
lizard
(Anolis carolinensis)
Reptilia TEKT3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt3 33
  • 67.76 (n)
Str.15141 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68964 33
zebrafish
(Danio rerio)
Actinopterygii tekt3 33 34
  • 62.77 (n)
wufc88h09 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000219 33
  • 52.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17450 33 34 35
  • 50.58 (n)
Tektin-A 35
  • 30 (a)
CG32819 34
  • 30 (a)
ManyToMany
CG32820 34
  • 30 (a)
ManyToMany
Tektin-C 35
  • 26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1706 33
Species where no ortholog for TEKT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT3 Gene

ENSEMBL:
Gene Tree for TEKT3 (if available)
TreeFam:
Gene Tree for TEKT3 (if available)

Paralogs for TEKT3 Gene

Paralogs for TEKT3 Gene

(4) SIMAP similar genes for TEKT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEKT3: view

Variants for TEKT3 Gene

Sequence variations from dbSNP and Humsavar for TEKT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041739 -- 15,316,412(+) GAACA(C/G)TGGTT intron-variant
rs1000050600 -- 15,322,278(+) ACAGC(C/T)CTGGT intron-variant, utr-variant-3-prime
rs1000291032 -- 15,310,246(+) GTGCA(C/T)GTCTT intron-variant
rs1000314703 -- 15,307,240(+) CAAAT(C/G)AGATC intron-variant
rs1000353338 -- 15,304,361(+) CCCAG(A/G)AGATA intron-variant

Variation tolerance for TEKT3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.82; 93.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TEKT3 Gene

Disorders for TEKT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEKT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 1e
  • charcot-marie-tooth disease type 1
- elite association - COSMIC cancer census association via MalaCards
Search TEKT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TEKT3

Genetic Association Database (GAD)
TEKT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT3
genes like me logo Genes that share disorders with TEKT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEKT3 Gene

Publications for TEKT3 Gene

  1. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. (PMID: 14735490) Roy A … Matzuk MM (Molecular reproduction and development 2004) 2 3 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K … Birren B (Genome research 2001) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TEKT3 Gene

Sources for TEKT3 Gene

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