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Aliases for TEKT3 Gene

Aliases for TEKT3 Gene

  • Tektin 3 2 3 5
  • Testicular Microtubules-Related Protein 3
  • Tektin-3 3

External Ids for TEKT3 Gene

Previous GeneCards Identifiers for TEKT3 Gene

  • GC17M015573
  • GC17M016322
  • GC17M015150
  • GC17M015407
  • GC17M015147
  • GC17M015207
  • GC17M015100

Summaries for TEKT3 Gene

Entrez Gene Summary for TEKT3 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT3 Gene

TEKT3 (Tektin 3) is a Protein Coding gene. Diseases associated with TEKT3 include Pelvic Varices. An important paralog of this gene is TEKT5.

UniProtKB/Swiss-Prot for TEKT3 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT3 Gene

Genomics for TEKT3 Gene

Regulatory Elements for TEKT3 Gene

Enhancers for TEKT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G015289 1.1 Ensembl ENCODE 19.2 +52.1 52051 1.2 TBP FOXA2 NFIB SREBF2 ZNF133 SIN3A YY1 RFX5 GTF3C2 POLR3A ENSG00000266538 TEKT3 LOC649873 RNU6-799P TBC1D26 RPS18P12 PIR38288 GC17M015300 PIR33019
GH17G015305 0.8 Ensembl ENCODE 22.1 +35.0 35021 3.4 HLF CEBPG MAFK NFE2L2 GABPA TEKT3 GC17P015309 PIR38288 GC17M015300
GH17G016312 1.4 ENCODE dbSUPER 12 -971.8 -971827 1.6 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZSWIM7 CENPV UPF3AP1 TEKT3 MIR1288 LRRC75A-AS1 LRRC75A TTC19 GC17M016316
GH17G015429 1.5 Ensembl ENCODE dbSUPER 11.1 -92.9 -92925 9.9 ATF1 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 GATA2 FOS LOC649873 CDRT4 TEKT3 RNU6-799P ENSG00000266538 GC17M015428 RPL9P2
GH17G015657 1.5 Ensembl ENCODE dbSUPER 10.1 -316.9 -316929 3.5 ATF1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 ENSG00000266538 TEKT3 ZNF624 CDRT1 CENPV CDRT4 MEIS3P1 ENSG00000251537 ZNF29P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEKT3 on UCSC Golden Path with GeneCards custom track

Promoters for TEKT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091611 388 600 PKNOX1 ATF1 KLF17 SIN3A BMI1 GLIS2 CREM SP3 NFYA ZEB2

Genomic Location for TEKT3 Gene

Chromosome:
17
Start:
15,303,811 bp from pter
End:
15,341,889 bp from pter
Size:
38,079 bases
Orientation:
Minus strand

Genomic View for TEKT3 Gene

Genes around TEKT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT3 Gene

Proteins for TEKT3 Gene

  • Protein details for TEKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXF9-TEKT3_HUMAN
    Recommended name:
    Tektin-3
    Protein Accession:
    Q9BXF9
    Secondary Accessions:
    • B2RAS7
    • D3DTT0
    • Q8N5R5
    • Q96M48

    Protein attributes for TEKT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    56636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT3 Gene

Post-translational modifications for TEKT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEKT3 Gene

Domains & Families for TEKT3 Gene

Gene Families for TEKT3 Gene

Protein Domains for TEKT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXF9

UniProtKB/Swiss-Prot:

TEKT3_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT3: view

Function for TEKT3 Gene

Molecular function for TEKT3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).

Gene Ontology (GO) - Molecular Function for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT3: view
genes like me logo Genes that share phenotypes with TEKT3: view

Animal Models for TEKT3 Gene

MGI Knock Outs for TEKT3:

Animal Model Products

miRNA for TEKT3 Gene

miRTarBase miRNAs that target TEKT3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEKT3 Gene

Localization for TEKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT3 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TEKT3: view

Pathways & Interactions for TEKT3 Gene

SuperPathways for TEKT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility ISS,IBA --
GO:0060271 cilium assembly ISS,IBA --
GO:0060294 cilium movement involved in cell motility IBA --
GO:0080154 regulation of fertilization ISS --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT3 Gene

Drugs & Compounds for TEKT3 Gene

No Compound Related Data Available

Transcripts for TEKT3 Gene

Unigene Clusters for TEKT3 Gene

Tektin 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for TEKT3 Gene

GeneLoc Exon Structure for
TEKT3
ECgene alternative splicing isoforms for
TEKT3

Expression for TEKT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT3 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT3 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for TEKT3 Gene

This gene is overexpressed in Plasma (55.8) and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT3 Gene



Protein tissue co-expression partners for TEKT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT3 Gene:

TEKT3

SOURCE GeneReport for Unigene cluster for TEKT3 Gene:

Hs.414648

Evidence on tissue expression from TISSUES for TEKT3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT3 Gene

Orthologs for TEKT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT3 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TEKT3 34 35
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia TEKT3 34 35
  • 87.62 (n)
mouse
(Mus musculus)
Mammalia Tekt3 34 16 35
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Tekt3 34
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia TEKT3 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT3 34 35
  • 73.01 (n)
lizard
(Anolis carolinensis)
Reptilia TEKT3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt3 34
  • 67.76 (n)
Str.15141 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68964 34
zebrafish
(Danio rerio)
Actinopterygii tekt3 34 35
  • 62.77 (n)
wufc88h09 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000219 34
  • 52.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17450 36 34 35
  • 50.58 (n)
Tektin-A 36
  • 30 (a)
CG32819 35
  • 30 (a)
ManyToMany
CG32820 35
  • 30 (a)
ManyToMany
Tektin-C 36
  • 26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1706 34
Species where no ortholog for TEKT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT3 Gene

ENSEMBL:
Gene Tree for TEKT3 (if available)
TreeFam:
Gene Tree for TEKT3 (if available)

Paralogs for TEKT3 Gene

Paralogs for TEKT3 Gene

(4) SIMAP similar genes for TEKT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEKT3: view

Variants for TEKT3 Gene

Sequence variations from dbSNP and Humsavar for TEKT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041739 -- 15,316,412(+) GAACA(C/G)TGGTT intron-variant
rs1000050600 -- 15,322,278(+) ACAGC(C/T)CTGGT intron-variant, utr-variant-3-prime
rs1000291032 -- 15,310,246(+) GTGCA(C/T)GTCTT intron-variant
rs1000314703 -- 15,307,240(+) CAAAT(C/G)AGATC intron-variant
rs1000353338 -- 15,304,361(+) CCCAG(A/G)AGATA intron-variant

Variation tolerance for TEKT3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.82; 93.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TEKT3 Gene

Disorders for TEKT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEKT3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search TEKT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TEKT3

Genetic Association Database (GAD)
TEKT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT3
genes like me logo Genes that share disorders with TEKT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEKT3 Gene

Publications for TEKT3 Gene

  1. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. (PMID: 14735490) Roy A. … Matzuk M.M. (Mol. Reprod. Dev. 2004) 2 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K. … Birren B. (Genome Res. 2001) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for TEKT3 Gene

Sources for TEKT3 Gene

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