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Aliases for TEKT2 Gene

Aliases for TEKT2 Gene

  • Tektin 2 2 3 5
  • Testicular Tektin B1-Like Protein 3 4
  • Tektin 2 (Testicular) 2 3
  • Tektin-B1 3 4
  • TEKTIN-T 3 4
  • TEKTB1 3 4
  • Testicular Tektin 4
  • H-Tektin-T 3
  • Tektin-2 3

External Ids for TEKT2 Gene

Previous GeneCards Identifiers for TEKT2 Gene

  • GC01P036371
  • GC01P035605
  • GC01P035976
  • GC01P035977
  • GC01P036218
  • GC01P036549
  • GC01P034666

Summaries for TEKT2 Gene

Entrez Gene Summary for TEKT2 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT2 Gene

TEKT2 (Tektin 2) is a Protein Coding gene. An important paralog of this gene is TEKT1.

UniProtKB/Swiss-Prot for TEKT2 Gene

  • Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT2 Gene

Genomics for TEKT2 Gene

Regulatory Elements for TEKT2 Gene

Enhancers for TEKT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G035935 1.3 Ensembl ENCODE 18.5 -147.8 -147834 2.3 PKNOX1 CREB3L1 ZFP64 SIN3A ARID4B DMAP1 CBX5 ZNF143 KLF13 SP3 TEKT2 LOC100128093 ADPRHL2 AGO1 C1orf216 AGO3 ENSG00000271914 LOC105378647
GH01G036114 1.3 Ensembl ENCODE dbSUPER 18.3 +31.9 31862 3.1 BCOR ZSCAN4 ZMYM3 ZIC2 ZNF48 ZNF664 E2F1 EGR1 POLR2A SMARCA5 TEKT2 ADPRHL2 LOC100128093 MAP7D1 TRAPPC3 LOC105378647 COL8A2
GH01G036169 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +90.6 90573 10.1 BCOR CTCF MXI1 PTBP1 JUN ZSCAN4 ZMYM3 RBBP5 BMI1 ZIC2 MAP7D1 ENSG00000116883 COL8A2 ADPRHL2 LOC100128093 TEKT2 SH3D21 EVA1B LSM10 RNU4-27P
GH01G036299 1.6 Ensembl ENCODE dbSUPER 10.3 +219.7 219709 8.8 HDGF PKNOX1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 STK40 ENSG00000201448 OSCP1 MAP7D1 TRAPPC3 LSM10 RNU4-27P TEKT2 LOC100128093 ADPRHL2
GH01G036133 1.4 Ensembl ENCODE dbSUPER 11.5 +51.7 51683 4.8 HDAC1 RB1 INSM2 RAD21 ZNF121 GATA2 ZNF143 FOS ZNF263 ZNF654 TRAPPC3 MAP7D1 ENSG00000271914 TFAP2E ADPRHL2 TEKT2 LOC100128093 AGO1 LSM10 COL8A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEKT2 on UCSC Golden Path with GeneCards custom track

Promoters for TEKT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004735 125 801 CTCF MXI1 KLF1 RBBP5 EBF1 BMI1 ZIC2 GLIS2 POLR2A PATZ1

Genomic Location for TEKT2 Gene

Chromosome:
1
Start:
36,084,075 bp from pter
End:
36,088,276 bp from pter
Size:
4,202 bases
Orientation:
Plus strand

Genomic View for TEKT2 Gene

Genes around TEKT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT2 Gene

Proteins for TEKT2 Gene

  • Protein details for TEKT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIF3-TEKT2_HUMAN
    Recommended name:
    Tektin-2
    Protein Accession:
    Q9UIF3
    Secondary Accessions:
    • A6NIS6
    • O60638

    Protein attributes for TEKT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    49672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT2 Gene

Post-translational modifications for TEKT2 Gene

Other Protein References for TEKT2 Gene

No data available for DME Specific Peptides for TEKT2 Gene

Domains & Families for TEKT2 Gene

Gene Families for TEKT2 Gene

Protein Domains for TEKT2 Gene

Suggested Antigen Peptide Sequences for TEKT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIF3

UniProtKB/Swiss-Prot:

TEKT2_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT2: view

Function for TEKT2 Gene

Molecular function for TEKT2 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).
genes like me logo Genes that share phenotypes with TEKT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TEKT2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT2 Gene

Localization for TEKT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT2 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In sperm, observed in a discontinuous punctate pattern in the flagellum and in the postacrosomal head region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center ISS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TEKT2: view

Pathways & Interactions for TEKT2 Gene

SuperPathways for TEKT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030317 flagellated sperm motility IBA,IEA --
GO:0036159 inner dynein arm assembly IEA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT2: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT2 Gene

Drugs & Compounds for TEKT2 Gene

No Compound Related Data Available

Transcripts for TEKT2 Gene

Unigene Clusters for TEKT2 Gene

Tektin 2 (testicular):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - -
SP8:
SP9: -

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TEKT2 Gene

GeneLoc Exon Structure for
TEKT2
ECgene alternative splicing isoforms for
TEKT2

Expression for TEKT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT2 Gene

This gene is overexpressed in Testis (x22.8) and Fallopian Tube (x5.3).

Protein differential expression in normal tissues from HIPED for TEKT2 Gene

This gene is overexpressed in Cervix (58.0) and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT2 Gene



Protein tissue co-expression partners for TEKT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT2 Gene:

TEKT2

SOURCE GeneReport for Unigene cluster for TEKT2 Gene:

Hs.127111

mRNA Expression by UniProt/SwissProt for TEKT2 Gene:

Q9UIF3-TEKT2_HUMAN
Tissue specificity: Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney.

Evidence on tissue expression from TISSUES for TEKT2 Gene

  • Nervous system(4.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with TEKT2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT2 Gene

Orthologs for TEKT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT2 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia TEKT2 34 35
  • 90.16 (n)
dog
(Canis familiaris)
Mammalia TEKT2 34
  • 84.58 (n)
mouse
(Mus musculus)
Mammalia Tekt2 34 16 35
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Tekt2 34
  • 83.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TEKT2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT2 34 35
  • 70.39 (n)
lizard
(Anolis carolinensis)
Reptilia TEKT2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt2 34
  • 67.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52862 34
zebrafish
(Danio rerio)
Actinopterygii tekt2 34 35
  • 58.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008275 34
  • 47.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3085 36 34 35
  • 47.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8168 35
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3656 34
Species where no ortholog for TEKT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT2 Gene

ENSEMBL:
Gene Tree for TEKT2 (if available)
TreeFam:
Gene Tree for TEKT2 (if available)

Paralogs for TEKT2 Gene

Paralogs for TEKT2 Gene

(4) SIMAP similar genes for TEKT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEKT2: view

Variants for TEKT2 Gene

Sequence variations from dbSNP and Humsavar for TEKT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000996105 -- 36,083,629(+) CATTT(G/T)GGGAG upstream-variant-2KB
rs1001092611 -- 36,084,048(+) GGCCG(C/T)GGGGG upstream-variant-2KB
rs1001320526 -- 36,083,356(+) GTCTC(A/G)GCCTC upstream-variant-2KB
rs1001783980 -- 36,083,964(+) GGCCG(-/C)CCCTC upstream-variant-2KB
rs1003238165 -- 36,087,126(+) TGGCC(C/T)CCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEKT2 Gene

Variant ID Type Subtype PubMed ID
esv2669773 CNV deletion 23128226
esv3585729 CNV loss 21293372
nsv834691 CNV loss 17160897

Variation tolerance for TEKT2 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT2 Gene

Human Gene Mutation Database (HGMD)
TEKT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT2 Gene

Disorders for TEKT2 Gene

Relevant External Links for TEKT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT2

No disorders were found for TEKT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT2 Gene

Publications for TEKT2 Gene

  1. Tektin B1 demonstrates flagellar localization in human sperm. (PMID: 11751288) Wolkowicz M.J. … Herr J.C. (Biol. Reprod. 2002) 2 3 4 22 64
  2. Cloning and characterization of the human tektin-t gene. (PMID: 12029069) Iguchi N. … Nishimune Y. (Mol. Hum. Reprod. 2002) 2 3 4 22 64
  3. A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report. (PMID: 18227105) Zuccarello D. … Foresta C. (Hum. Reprod. 2008) 3 22 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TEKT2 Gene

Sources for TEKT2 Gene

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