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Aliases for TEKT2 Gene

Aliases for TEKT2 Gene

  • Tektin 2 2 3 5
  • Testicular Tektin B1-Like Protein 3 4
  • Tektin 2 (Testicular) 2 3
  • Tektin-B1 3 4
  • TEKTIN-T 3 4
  • TEKTB1 3 4
  • Testicular Tektin 4
  • H-Tektin-T 3
  • Tektin-2 3

External Ids for TEKT2 Gene

Previous GeneCards Identifiers for TEKT2 Gene

  • GC01P036371
  • GC01P035605
  • GC01P035976
  • GC01P035977
  • GC01P036218
  • GC01P036549
  • GC01P034666

Summaries for TEKT2 Gene

Entrez Gene Summary for TEKT2 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT2 Gene

TEKT2 (Tektin 2) is a Protein Coding gene. An important paralog of this gene is TEKT1.

UniProtKB/Swiss-Prot for TEKT2 Gene

  • Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Additional gene information for TEKT2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT2 Gene

Genomics for TEKT2 Gene

GeneHancer (GH) Regulatory Elements for TEKT2 Gene

Promoters and enhancers for TEKT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I036083 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 557.1 +0.0 42 1.2 MXI1 KLF1 SIN3A EBF1 BMI1 ZIC2 GLIS2 POLR2A PATZ1 VEZF1 TEKT2 LOC100128093 LOC105378647 AGO3 MAP7D1 ADPRHL2
GH01I036299 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.3 +219.7 219708 8.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SH3D21 STK40 SNORA63C OSCP1 TRAPPC3 MAP7D1 LSM10 RNU4-27P LOC100128093 TEKT2
GH01I036222 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +140.3 140317 4.7 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 THRAP3 MAP7D1 TRAPPC3 COL8A2 ADPRHL2 LOC100128093 TEKT2 LSM10 RNU4-27P SNORA63C
GH01I035882 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 -198.4 -198404 6.2 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 KLF13 AGO1 AGO3 ZMYM4 LOC100128093 TEKT2 ADPRHL2 C1orf216 ENSG00000271164 PIR56740 GC01P035916
GH01I036114 Enhancer 1 Ensembl ENCODE dbSUPER 18.3 +31.9 31862 3.1 SMARCA5 BCOR ZBTB6 ZMYM3 ZNF16 ZIC2 ZNF48 KAT8 ZNF664 E2F1 TEKT2 SFPQ ADPRHL2 RPL5P4 LOC100128093 MAP7D1 TRAPPC3 LOC105378647 COL8A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEKT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEKT2 gene promoter:

Genomic Locations for TEKT2 Gene

Genomic Locations for TEKT2 Gene
chr1:36,084,075-36,088,276
(GRCh38/hg38)
Size:
4,202 bases
Orientation:
Plus strand
chr1:36,549,676-36,553,876
(GRCh37/hg19)

Genomic View for TEKT2 Gene

Genes around TEKT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT2 Gene

Proteins for TEKT2 Gene

  • Protein details for TEKT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIF3-TEKT2_HUMAN
    Recommended name:
    Tektin-2
    Protein Accession:
    Q9UIF3
    Secondary Accessions:
    • A6NIS6
    • O60638

    Protein attributes for TEKT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    49672 Da
    Quaternary structure:
    • May interact with CCDC172.

neXtProt entry for TEKT2 Gene

Post-translational modifications for TEKT2 Gene

Other Protein References for TEKT2 Gene

No data available for DME Specific Peptides for TEKT2 Gene

Domains & Families for TEKT2 Gene

Gene Families for TEKT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIF3

UniProtKB/Swiss-Prot:

TEKT2_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT2: view

Function for TEKT2 Gene

Molecular function for TEKT2 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
genes like me logo Genes that share phenotypes with TEKT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT2 Gene

Localization for TEKT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT2 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Colocalized with CCDC172 at the perinuclear region. {ECO:0000250 UniProtKB:Q922G7}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA,ISS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TEKT2: view

Pathways & Interactions for TEKT2 Gene

SuperPathways for TEKT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030317 flagellated sperm motility IBA,IEA --
GO:0036159 inner dynein arm assembly IEA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT2: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT2 Gene

Drugs & Compounds for TEKT2 Gene

No Compound Related Data Available

Transcripts for TEKT2 Gene

Unigene Clusters for TEKT2 Gene

Tektin 2 (testicular):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - -
SP8:
SP9: -

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TEKT2 Gene

GeneLoc Exon Structure for
TEKT2
ECgene alternative splicing isoforms for
TEKT2

Expression for TEKT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT2 Gene

This gene is overexpressed in Testis (x22.8) and Fallopian Tube (x5.3).

Protein differential expression in normal tissues from HIPED for TEKT2 Gene

This gene is overexpressed in Cervix (58.0) and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT2 Gene



Protein tissue co-expression partners for TEKT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEKT2 Gene:

TEKT2

SOURCE GeneReport for Unigene cluster for TEKT2 Gene:

Hs.127111

mRNA Expression by UniProt/SwissProt for TEKT2 Gene:

Q9UIF3-TEKT2_HUMAN
Tissue specificity: Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney.

Evidence on tissue expression from TISSUES for TEKT2 Gene

  • Nervous system(4.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with TEKT2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT2 Gene

Orthologs for TEKT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT2 33 34
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia TEKT2 33 34
  • 90.16 (n)
dog
(Canis familiaris)
Mammalia TEKT2 33
  • 84.58 (n)
mouse
(Mus musculus)
Mammalia Tekt2 33 16 34
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Tekt2 33
  • 83.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TEKT2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT2 33 34
  • 70.39 (n)
lizard
(Anolis carolinensis)
Reptilia TEKT2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt2 33
  • 67.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52862 33
zebrafish
(Danio rerio)
Actinopterygii tekt2 33 34
  • 58.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008275 33
  • 47.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3085 35 33 34
  • 47.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8168 34
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3656 33
Species where no ortholog for TEKT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT2 Gene

ENSEMBL:
Gene Tree for TEKT2 (if available)
TreeFam:
Gene Tree for TEKT2 (if available)

Paralogs for TEKT2 Gene

Paralogs for TEKT2 Gene

(4) SIMAP similar genes for TEKT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEKT2: view

Variants for TEKT2 Gene

Sequence variations from dbSNP and Humsavar for TEKT2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000996105 -- 36,083,629(+) T/G upstream_transcript_variant
rs1001092611 -- 36,084,048(+) C/T upstream_transcript_variant
rs1001320526 -- 36,083,356(+) G/A upstream_transcript_variant
rs1001783980 -- 36,083,964(+) CCCC/CCC upstream_transcript_variant
rs1003238165 -- 36,087,126(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT2 Gene

Variant ID Type Subtype PubMed ID
esv2669773 CNV deletion 23128226
esv3585729 CNV loss 21293372
nsv834691 CNV loss 17160897

Variation tolerance for TEKT2 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT2 Gene

Human Gene Mutation Database (HGMD)
TEKT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT2 Gene

Disorders for TEKT2 Gene

Additional Disease Information for TEKT2

No disorders were found for TEKT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT2 Gene

Publications for TEKT2 Gene

  1. Tektin B1 demonstrates flagellar localization in human sperm. (PMID: 11751288) Wolkowicz MJ … Herr JC (Biology of reproduction 2002) 2 3 4 22 58
  2. Cloning and characterization of the human tektin-t gene. (PMID: 12029069) Iguchi N … Nishimune Y (Molecular human reproduction 2002) 2 3 4 22 58
  3. A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report. (PMID: 18227105) Zuccarello D … Foresta C (Human reproduction (Oxford, England) 2008) 3 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TEKT2 Gene

Sources for TEKT2 Gene

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