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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEKT2 Gene

protein-coding   GIFtS: 50
GCID: GC01P036549

tektin 2 (testicular)

 Explore 4 diseases affiliated with
TEKT2 via our new
 Human Malady Compendium 
Biological research products
for TEKT2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tektin 2 (Testicular)1 2     Tektin-21
TEKTB11 2 3     Tektin-B13
Testicular Tektin B1-Like Protein2 3     Tektin-B13
TEKTIN-T2     Tektin-T1
H-Tektin-T1     Testicular Tektin3

External Ids:    HGNC: 117251   Entrez Gene: 272852   Ensembl: ENSG000000928507   OMIM: 6089535   UniProtKB: Q9UIF33   

Export aliases for TEKT2 gene to outside databases

Previous GC identifers: GC01P036371 GC01P035605 GC01P035976 GC01P035977 GC01P036218 GC01P034666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEKT2:
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that
are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its
protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TEKT2_HUMAN, Q9UIF3
Function: Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of
the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of
ciliary and flagellar microtubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEKT2 gene promoter:
         HOXA9   HOXA9B   AREB6   AML1a   HTF   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEKT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEKT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

TEKT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEKT2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036549:  view genomic region     (about GC identifiers)

Start:
36,549,676 bp from pter      End:
36,553,876 bp from pter
Size:
4,201 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEKT2_HUMAN, Q9UIF3 (See protein sequence)
Recommended Name: Tektin-2  
Size: 430 amino acids; 49672 Da
Subcellular location: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm,
cytoskeleton, flagellum axoneme. Note=In sperm, observed in a discontinuous punctate pattern in the flagellum and in
the postacrosomal head region
Secondary accessions: A6NIS6 O60638

Explore the universe of human proteins at neXtProt for TEKT2: NX_Q9UIF3

Post-translational modifications:

  • Tyrosine phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UIF3

  • TEKT2 Protein expression data from MOPED and PaxDb:    About this image 
    TEKT2 Protein Expression
    REFSEQ proteins: NP_055281.2  
    ENSEMBL proteins: 
     ENSP00000207457   ENSP00000434183   ENSP00000432793  

    Human Recombinant Protein Products for TEKT2: 
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    Uscn Proteins for TEKT2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0035085cilium axoneme IEA--

    TEKT2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TEKT2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000435 Tektin

    Graphical View of Domain Structure for InterPro Entry Q9UIF3

    ProtoNet protein and cluster: Q9UIF3

    1 Blocks protein family: IPB000435 Tektin signature

    UniProtKB/Swiss-Prot: TEKT2_HUMAN, Q9UIF3
    Similarity: Belongs to the tektin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEKT2_HUMAN, Q9UIF3
    Function: Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of
    the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of
    ciliary and flagellar microtubules (By similarity)

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tekt2):

     reproductive system  respiratory system 

    TEKT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TEKT2 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT2

    5/8 Interacting proteins for TEKT2 (Q9UIF33) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APODP050903I2D: score=5 
    GNB4Q9HAV03I2D: score=5 
    KLC1Q078663I2D: score=5 
    NDUFS1P283313I2D: score=5 
    RPSAP088653I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001539ciliary or flagellar motility IEA--
    GO:0030030cell projection organization IEA--
    GO:0030317sperm motility IEA--

    TEKT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEKT2
    Search CenterWatch for drugs/clinical trials and news about TEKT2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEKT2 gene: 
    NM_014466.2  

    Unigene Cluster for TEKT2:

    Tektin 2 (testicular)
    Hs.127111  [show with all ESTs]
    Unigene Representative Sequence: BC022005
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000207457(uc001bzr.3) ENST00000469024(uc001bzs.3) ENST00000473120


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    Additional cDNA sequence: 

    AB033823.1 AF054910.1 AK313610.1 BC022005.1 BC035620.1 

    3 DOTS entries:

    DT.303710  DT.95160621  DT.91753069 

    23 AceView cDNA sequences:

    BE378408 NM_014466 AB033823 BC035620 BI818864 AI922175 BI827640 BC022005 
    BI831314 BV183333 BQ045351 BG720240 BI461321 AF054910 CB250682 AW769377 
    BU682715 CD705666 AI432521 CD697685 BI561479 T78294 AA936586 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TEKT2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:              -     -     -     -     -     -     -                             -     -                                                                     
    SP2:              -     -     -     -     -     -     -                             -     -     -                                                               
    SP3:                    -     -     -     -     -     -                             -     -                                                                     
    SP4:                                            -     -                             -                                                                           
    SP5:                                                  -                             -     -                                                                     

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TEKT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEKT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACACGCGGC
    TEKT2 Expression
    About this image

    TEKT2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See TEKT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEKT2

    SOURCE GeneReport for Unigene cluster: Hs.127111

    UniProtKB/Swiss-Prot: TEKT2_HUMAN, Q9UIF3
    Tissue specificity: Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary,
    pituitary, adult lung, fetal brain and fetal kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TEKT2 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TEKT21 tektin 2 (testicular) 70.47(n)
    69.46(a)
      419627  XM_417774.3  XP_417774.3 
    lizard
    (Anolis carolinensis)
    Reptilia TEKT26
    --
    75(a)
    1 ↔ 1
    GL343488.1(601164-608571)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528622 similar to tektin 2 (testicular) 74.82(n)    BC043740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tekt21 tektin 2 (testicular) 58.56(n)
    52.38(a)
      550629  NM_001017432.3  NP_001017432.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30851 , 3 CG30851 31(a)3
    46.97(n)1
    31.97(a)1
      59C33
    376631  NM_137908.21  NP_611752.11 


    ENSEMBL Gene Tree for TEKT2 (if available)
    TreeFam Gene Tree for TEKT2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEKT2 gene
    ENSG000002156152  TEKT42  TEKT52  ENSG000002157502  TEKT12  TEKT32  
    4 SIMAP similar genes for TEKT2 using alignment to 4 protein entries:     TEKT2_HUMAN (see all proteins):
    TEKT5    TEKT1    TEKT4    TEKT3

    TEKT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/175 NCBI SNPs in TEKT2 are shown (see all 175    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887293091,2
    --36547935(+) AGAGTA/GTCCTC 1 -- us2k10--------
    rs37540711,2
    C,F,A--36548081(+) TAGAAA/GTACTA 1 -- us2k15Minor allele frequency- G:0.15NA WA CSA EA 244
    rs1815318501,2
    --36548084(+) AAATAC/TTAGGC 1 -- us2k10--------
    rs1433835091,2
    --36548138(+) TTTTTC/TCCCTT 1 -- us2k10--------
    rs1127728401,2
    --36548237(+) GTCTCA/C/GTTCTG 1 -- us2k11CSA 2
    rs766727511,2
    F--36548266(+) AGAGGC/TGTGTT 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs15556531,2
    C,F,A--36548287(-) CGGAGG/TTTGCA 1 -- us2k17Minor allele frequency- T:0.37EA NA CSA 182
    rs37540731,2
    C--36548291(+) ACCTCC/TGCCTC 1 -- us2k13Minor allele frequency- T:0.14NA EA 124
    rs37540741,2
    C,F,A,H--36548354(+) GCGTGT/CGCCAC 1 -- us2k116Minor allele frequency- C:0.25EA NS NA CSA WA 1820
    rs773571611,2
    --36548380(+) CATACC/TCCAGT 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for TEKT2 (36549676 - 36553876 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TEKT2: --
    Human Gene Mutation Database (HGMD): TEKT2

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TEKT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TEKT2 for disorders           About GeneDecksing

    OMIM gene information: 608953    OMIM disorders: --

    4 diseases for TEKT2:    About MalaCards
    ciliary dyskinesia    primary ciliary dyskinesia    male infertility    infertility

    2 diseases from the University of Copenhagen DISEASES database for TEKT2:
    Primary ciliary dyskinesia     Male infertility

    Export disorders for TEKT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEKT2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TEKT2)
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    1. Cloning and characterization of the human tektin-t gene. (PubMed id 12029069)1, 2, 3, 9 Iguchi N....Nishimune Y. (2002)
    2. Tektin B1 demonstrates flagellar localization in human sperm. (PubMed id 11751288)1, 2, 3, 9 Wolkowicz M.J.... Herr J.C. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report. (PubMed id 18227105)1, 9 Zuccarello D....Foresta C. (2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. (PubMed id 15340058)1 Tanaka H....Nishimune Y. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Tektin B1 from ciliary microtubules: primary structure as deduced from the cDNA sequence and comparison with tektin A1. (PubMed id 8308073)9 Chen R....Linck R.W. (1993)
    10. Inhibition of tyrosine phosphorylation of sperm flage llar proteins, outer dense fiber protein-2 and tektin-2, is associated with imp aired motility during capacitation of hamster spermatozoa. (PubMed id 19953638)9 Mariappa D....Seshagiri P.B. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27285 HGNC: 11725 AceView: TEKT2 Ensembl:ENSG00000092850 euGenes: HUgn27285
    ECgene: TEKT2 H-InvDB: TEKT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEKT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEKT2 gene:
    Search GeneIP for patents involving TEKT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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