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Aliases for TEKT2 Gene

Aliases for TEKT2 Gene

  • Tektin 2 (Testicular) 2 3
  • Testicular Tektin B1-Like Protein 3 4
  • Tektin-B1 3 4
  • TEKTIN-T 3 4
  • TEKTB1 3 4
  • Testicular Tektin 4
  • H-Tektin-T 3
  • Tektin-2 3

External Ids for TEKT2 Gene

Previous GeneCards Identifiers for TEKT2 Gene

  • GC01P036371
  • GC01P035605
  • GC01P035976
  • GC01P035977
  • GC01P036218
  • GC01P036549
  • GC01P034666

Summaries for TEKT2 Gene

Entrez Gene Summary for TEKT2 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT2 Gene

TEKT2 (Tektin 2 (Testicular)) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT2 Gene

  • Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT2 Gene

Genomics for TEKT2 Gene

Regulatory Elements for TEKT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TEKT2 Gene

Start:
36,084,075 bp from pter
End:
36,088,276 bp from pter
Size:
4,202 bases
Orientation:
Plus strand

Genomic View for TEKT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEKT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT2 Gene

Proteins for TEKT2 Gene

  • Protein details for TEKT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIF3-TEKT2_HUMAN
    Recommended name:
    Tektin-2
    Protein Accession:
    Q9UIF3
    Secondary Accessions:
    • A6NIS6
    • O60638

    Protein attributes for TEKT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    49672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT2 Gene

Proteomics data for TEKT2 Gene at MOPED

Post-translational modifications for TEKT2 Gene

Other Protein References for TEKT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEKT2 Gene

Domains for TEKT2 Gene

Protein Domains for TEKT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIF3

UniProtKB/Swiss-Prot:

TEKT2_HUMAN :
  • Q9UIF3
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT2: view

No data available for Gene Families for TEKT2 Gene

Function for TEKT2 Gene

Molecular function for TEKT2 Gene

UniProtKB/Swiss-Prot Function: Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).

Phenotypes for TEKT2 Gene

genes like me logo Genes that share phenotypes with TEKT2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TEKT2 Gene

Localization for TEKT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT2 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In sperm, observed in a discontinuous punctate pattern in the flagellum and in the postacrosomal head region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT2 Gene COMPARTMENTS Subcellular localization image for TEKT2 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TEKT2: view

Pathways for TEKT2 Gene

SuperPathways for TEKT2 Gene

No Data Available

Interacting Proteins for TEKT2 Gene

Selected Interacting proteins: Q9UIF3-TEKT2_HUMAN for TEKT2 Gene via I2D

Gene Ontology (GO) - Biological Process for TEKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030317 sperm motility IEA --
GO:0036159 inner dynein arm assembly IEA --
genes like me logo Genes that share ontologies with TEKT2: view

No data available for Pathways by source for TEKT2 Gene

Transcripts for TEKT2 Gene

mRNA/cDNA for TEKT2 Gene

Unigene Clusters for TEKT2 Gene

Tektin 2 (testicular):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - -
SP8:
SP9: -

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TEKT2 Gene

GeneLoc Exon Structure for
TEKT2
ECgene alternative splicing isoforms for
TEKT2

Expression for TEKT2 Gene

mRNA expression in normal human tissues for TEKT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT2 Gene

This gene is overexpressed in Testis (22.8) and Fallopian Tube (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TEKT2 Gene

SOURCE GeneReport for Unigene cluster for TEKT2 Gene Hs.127111

mRNA Expression by UniProt/SwissProt for TEKT2 Gene

Q9UIF3-TEKT2_HUMAN
Tissue specificity: Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney.
genes like me logo Genes that share expressions with TEKT2: view

In Situ Assay Products

Orthologs for TEKT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT2 35
  • 99.38 (n)
  • 99.07 (a)
TEKT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT2 35
  • 90.16 (n)
  • 91.4 (a)
TEKT2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT2 35
  • 84.58 (n)
  • 83.41 (a)
mouse
(Mus musculus)
Mammalia Tekt2 35
  • 83.92 (n)
  • 83.92 (a)
Tekt2 16
Tekt2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEKT2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt2 35
  • 83.61 (n)
  • 84.15 (a)
chicken
(Gallus gallus)
Aves TEKT2 35
  • 70.39 (n)
  • 69.3 (a)
TEKT2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT2 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52862 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt2 35
  • 67.21 (n)
  • 68.84 (a)
zebrafish
(Danio rerio)
Actinopterygii tekt2 35
  • 58.35 (n)
  • 52.12 (a)
tekt2 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008275 35
  • 47.83 (n)
  • 33.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3085 35
  • 47.02 (n)
  • 32.49 (a)
CG3085 36
  • 31 (a)
OneToOne
CG3085 37
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3656 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8168 36
  • 60 (a)
OneToOne
Species with no ortholog for TEKT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT2 Gene

ENSEMBL:
Gene Tree for TEKT2 (if available)
TreeFam:
Gene Tree for TEKT2 (if available)

Paralogs for TEKT2 Gene

Paralogs for TEKT2 Gene

Selected SIMAP similar genes for TEKT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEKT2: view

Variants for TEKT2 Gene

Sequence variations from dbSNP and Humsavar for TEKT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs408986 -- 36,086,294(+) CACCC(A/G)TTTGC intron-variant
rs413307 -- 36,085,508(+) ttttc(C/T)ttttt intron-variant
rs419653 - 36,085,894(+) GGCCA(C/T)TGAGT missense, reference
rs1555653 -- 36,082,686(-) CGGAG(G/T)TTGCA upstream-variant-2KB
rs2274122 -- 36,084,063(-) CCCTA(C/T)CCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEKT2 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834691 CNV Loss 17160897
nsv871804 CNV Loss 21882294
esv2669773 CNV Deletion 23128226

Relevant External Links for TEKT2 Gene

HapMap Linkage Disequilibrium report
TEKT2
Human Gene Mutation Database (HGMD)
TEKT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT2 Gene

Disorders for TEKT2 Gene

(1) University of Copenhagen DISEASES for TEKT2 Gene

genes like me logo Genes that share disorders with TEKT2: view

No data available for UniProtKB/Swiss-Prot for TEKT2 Gene

Publications for TEKT2 Gene

  1. Tektin B1 demonstrates flagellar localization in human sperm. (PMID: 11751288) Wolkowicz M.J. … Herr J.C. (Biol. Reprod. 2002) 2 3 4 23
  2. Cloning and characterization of the human tektin-t gene. (PMID: 12029069) Iguchi N. … Nishimune Y. (Mol. Hum. Reprod. 2002) 2 3 4 23
  3. A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report. (PMID: 18227105) Zuccarello D. … Foresta C. (Hum. Reprod. 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TEKT2 Gene

Sources for TEKT2 Gene

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