TEKT1 Gene
protein-coding GIFtS : 48
GCID: GC17 M006692
tektin 1
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Aliasesfor TEKT1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tektin 1 1 2 Tektin-11
Export aliases for TEKT1 gene to outside databases Previous GC identifers: GC17M007092 GC17M007432 GC17M006645 GC17M006901 GC17M006644
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Summariesfor TEKT1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TEKT1 : This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4 Function : Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules Gene Wiki entry for TEKT1
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Genomic Viewsfor TEKT1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TEKT1 gene promoter: ISGF-3 AML1a NF-AT S8 NF-AT4 NF-AT2 FOXO4 NF-AT3 NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for TEKT1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.2 TEKT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M006692: view genomic region
(about GC identifiers )
Start:
6,692,452 bp from pter
End:
6,735,080 bp from pter
Size:
42,629 bases
Orientation:
minus strand
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Proteinsfor TEKT1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4 (See
protein sequence )Recommended Name: Tektin-1 Size : 418 amino acids; 48283 Da
Subcellular location : Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme
Secondary accessions : D3DTM7Explore the universe of human proteins at neXtProt for TEKT1: NX_Q969V4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q969V4 TEKT1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_444515.1 ENSEMBL proteins: ENSP00000460197 ENSP00000341346 ENSP00000460359 ENSP00000458518 ENSP00000444142 Human Recombinant Protein Products for TEKT1: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TEKT1 for ontologies About GeneDecksing TEKT1 Antibody Products: Assay Products for TEKT1:
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Protein
Domains / Familiesfor TEKT1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TEKT1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q969V4 ProtoNet protein and cluster: Q969V4
1 Blocks protein family : IPB000435 Tektin signature UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4 Similarity : Belongs to the tektin family
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Functionfor TEKT1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TEKT1_HUMAN, Q969V4 Function : Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls ofciliary and flagellar microtubules Phenotypes: 1 GenomeRNAi human phenotype for TEKT1 :
Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TEKT1 (NM_053285 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEKT1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT1
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Pathways & Interactionsfor TEKT1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEKT1 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000226 microtubule cytoskeleton organization
IEA --
TEKT1 for ontologies About GeneDecksing
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Drugs & Compoundsfor TEKT1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TEKT1 Search CenterWatch for drugs/clinical trials and news about TEKT1
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Transcriptsfor TEKT1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TEKT1 gene: NM_053285.1 Unigene Cluster for TEKT1:
Tektin 1 Hs.462108 [show with all ESTs ] Unigene Representative Sequence: AK094836 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000571744 ENST00000338694 (uc002gdt.3 ) ENST00000575592 (uc010vth.2 )ENST00000572291 ENST00000573966 ENST00000535086 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TEKT1 (NM_053285 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TEKT1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEKT1
Additional cDNA sequence: AF357879.1 AK094836.1 AK292818.1 AK304345.1 BC014599.2
3 DOTS entries : DT.101231 DT.95201810
DT.95366672 24/50 AceView cDNA sequences (see all 50 ):
BM725244 BM973153 BM973832 CA450315 BC014599 NM_053285 BG545924 BU684424 AF357879 AA994630 AI219651 T17287 BM677689 BM998386 BI831036 CF455699 BG702745 BI461320 BP369033 BM559817 CA311610 BQ045232 BE856305 BP370281 GeneLoc Exon Structure
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Expression for TEKT1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TEKT1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGGTCTGGGCAbout this image TEKT1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See TEKT1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TEKT1 SOURCE GeneReport for Unigene cluster: Hs.462108 UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4 Tissue specificity : Predominantly expressed in testis SABiosciences Custom PCR Arrays for TEKT1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TEKT1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TEKT1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TEKT1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TEKT1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT1
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Orthologsfor TEKT1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TEKT1 gene from 6/20 species (see all 20 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
TEKT11
tektin 1
66.75(n) 65.24(a)
 
417686 XM_415931.2 XP_415931.2
lizard (Anolis carolinensis)
Reptilia
TEKT16
--
60(a)
1 ↔ 1
GL344820.1(17516-20164)
African clawed frog (Xenopus laevis)
Amphibia
Xl.300122
Xenopus laevis transcribed sequence with moderate similarity more
71.28(n)
 
BJ050015.1
zebrafish (Danio rerio)
Actinopterygii
zgc:1017971
zgc:101797
57.87(n) 48.48(a)
 
492525 NM_001007397.1 NP_001007398.1
fruit fly (Drosophila melanogaster)
Insecta
Tektin-C1 , 3
microtubule-based process microtubule binding3 Tektin C1
32(a) (best of 2)3 47.04(n) 1 32.39(a) 1
 
64E83 38653 1 NM_001104050.1 1 NP_001097520.1 1
worm (Caenorhabditis elegans)
Secernentea
R02E12.41
Protein R02E12.4
40.7(n) 25.26(a)
 
187525 NM_076288.1 NP_508689.1
ENSEMBL Gene Tree for TEKT1 (if available)TreeFam Gene Tree for TEKT1 (if available)
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Paralogsfor TEKT1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TEKT1 gene ENSG00000215615 2 TEKT4 2 TEKT5 2 TEKT2 2 ENSG00000215750 2 TEKT3 2 5 SIMAP similar genes for TEKT1 using alignment to 5 protein entries: TEKT1_HUMAN (see all proteins ):TEKT5 LOC389833 TEKT3 TEKT4 TEKT2
TEKT1 for paralogs About GeneDecksing
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Genomic Variantsfor TEKT1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TEKT1 (6692452 - 6735080 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TEKT1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TEKT1
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Disorders
/ Diseasesfor TEKT1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TEKT1 for disorders About GeneDecksing
OMIM gene information: 609002
OMIM disorders : --1 disease for TEKT1 : About MalaCards graves' disease Human Genome Epidemiology (HuGE) Navigator: TEKT1 (2 documents) Export disorders for TEKT1 gene to outside databases
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Publicationsfor TEKT1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TEKT1 gene integrated from 9 sources : (articles sorted by number of sources associating them with TEKT1) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of a novel human TEKTIN1 gene. (PubMed id 11606253) 1 , 2 , 3 Xu M.... Mao Y. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Follow-up of potential novel Graves' disease suscepti bility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PubMed id 20442750) 1 Newby P.R....Gough S.C. (2010) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Cloning and characterization of the human tektin-t gene. (PubMed id 12029069) 1 Iguchi N....Nishimune Y. (2002)
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External Searches for TEKT1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TEKT1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TEKT1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TEKT1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TEKT1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TEKT1 gene: Search GeneIP for patents involving TEKT1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TEKT1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TEKT1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TEKT1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TEKT1 OriGene Protein Over-expression Lysate for TEKT1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TEKT1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TEKT1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TEKT1 OriGene Custom Protein Services for TEKT1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TEKT1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TEKT1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEKT1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TEKT1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TEKT1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TEKT1
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TEKT1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT1
ThermoFisher Antibodies for TEKT1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TEKT1
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Aliases for TEKT1
Databases for TEKT1
Disorders / Diseases for TEKT1
Domains / Families for TEKT1
Drugs / Compounds for TEKT1
Expression for TEKT1
Function for TEKT1
Genomic Views for TEKT1
Intellectual Property for TEKT1
Orthologs for TEKT1
Paralogs for TEKT1
Pathways / Interactions for TEKT1
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Proteins for TEKT1
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Summaries for TEKT1
Transcripts for TEKT1
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