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Aliases for TEKT1 Gene

Aliases for TEKT1 Gene

  • Tektin 1 2 3
  • Tektin-1 3

External Ids for TEKT1 Gene

Previous GeneCards Identifiers for TEKT1 Gene

  • GC17M007092
  • GC17M007432
  • GC17M006645
  • GC17M006901
  • GC17M006644
  • GC17M006692

Summaries for TEKT1 Gene

Entrez Gene Summary for TEKT1 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT1 Gene

TEKT1 (Tektin 1) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT1 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules

Gene Wiki entry for TEKT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT1 Gene

Genomics for TEKT1 Gene

Regulatory Elements for TEKT1 Gene

Genomic Location for TEKT1 Gene

Start:
6,789,133 bp from pter
End:
6,831,761 bp from pter
Size:
42,629 bases
Orientation:
Minus strand

Genomic View for TEKT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEKT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT1 Gene

Proteins for TEKT1 Gene

  • Protein details for TEKT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V4-TEKT1_HUMAN
    Recommended name:
    Tektin-1
    Protein Accession:
    Q969V4
    Secondary Accessions:
    • D3DTM7

    Protein attributes for TEKT1 Gene

    Size:
    418 amino acids
    Molecular mass:
    48283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT1 Gene

Proteomics data for TEKT1 Gene at MOPED

Post-translational modifications for TEKT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT1 Gene

No data available for DME Specific Peptides for TEKT1 Gene

Domains for TEKT1 Gene

Protein Domains for TEKT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V4

UniProtKB/Swiss-Prot:

TEKT1_HUMAN :
  • Q969V4
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT1: view

No data available for Gene Families for TEKT1 Gene

Function for TEKT1 Gene

Molecular function for TEKT1 Gene

UniProtKB/Swiss-Prot Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules

Gene Ontology (GO) - Molecular Function for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT1: view

Phenotypes for TEKT1 Gene

GenomeRNAi human phenotypes for TEKT1:
genes like me logo Genes that share phenotypes with TEKT1: view

Animal Model Products

CRISPR Products

miRNA for TEKT1 Gene

miRTarBase miRNAs that target TEKT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TEKT1 Gene

Localization for TEKT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEKT1 Gene COMPARTMENTS Subcellular localization image for TEKT1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with TEKT1: view

Pathways for TEKT1 Gene

SuperPathways for TEKT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT1 Gene

None

No data available for Pathways by source for TEKT1 Gene

Transcripts for TEKT1 Gene

Unigene Clusters for TEKT1 Gene

Tektin 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEKT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT1 Gene

No ASD Table

Relevant External Links for TEKT1 Gene

GeneLoc Exon Structure for
TEKT1
ECgene alternative splicing isoforms for
TEKT1

Expression for TEKT1 Gene

mRNA expression in normal human tissues for TEKT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT1 Gene

This gene is overexpressed in Testis (16.4), Fallopian Tube (7.4), Brain - Hypothalamus (4.8), and Cervix - Endocervix (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEKT1 Gene

SOURCE GeneReport for Unigene cluster for TEKT1 Gene Hs.462108

mRNA Expression by UniProt/SwissProt for TEKT1 Gene

Q969V4-TEKT1_HUMAN
Tissue specificity: Predominantly expressed in testis.
genes like me logo Genes that share expressions with TEKT1: view

In Situ Assay Products

Orthologs for TEKT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT1 35
  • 99.2 (n)
  • 98.8 (a)
TEKT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT1 35
  • 87.08 (n)
  • 86.36 (a)
TEKT1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT1 35
  • 81.64 (n)
  • 82.37 (a)
TEKT1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tekt1 35
  • 81.74 (n)
  • 82.54 (a)
Tekt1 16
Tekt1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt1 35
  • 81.82 (n)
  • 82.78 (a)
chicken
(Gallus gallus)
Aves TEKT1 35
  • 66.42 (n)
  • 64.59 (a)
TEKT1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT1 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30012 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt1 35
  • 65.5 (n)
  • 68.67 (a)
zebrafish
(Danio rerio)
Actinopterygii tekt1 35
  • 57.74 (n)
  • 48.23 (a)
tekt1 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007334 35
  • 46.8 (n)
  • 33.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tektin-C 35
  • 46.8 (n)
  • 31.82 (a)
Tektin-C 37
  • 32 (a)
Tektin-A 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 35
  • 41.67 (n)
  • 26.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9917 36
  • 56 (a)
OneToOne
Species with no ortholog for TEKT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT1 Gene

ENSEMBL:
Gene Tree for TEKT1 (if available)
TreeFam:
Gene Tree for TEKT1 (if available)

Paralogs for TEKT1 Gene

Paralogs for TEKT1 Gene

Selected SIMAP similar genes for TEKT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TEKT1: view

Variants for TEKT1 Gene

Sequence variations from dbSNP and Humsavar for TEKT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1228492 -- 6,829,756(-) AGATT(A/T)CAACA intron-variant
rs2136282 -- 6,800,954(+) AAAAA(A/G)GATTA intron-variant
rs2271233 - 6,800,802(+) TGCGA(C/T)ATCAC missense, reference
rs2271234 -- 6,800,872(+) GCTGG(C/T)CCTTC synonymous-codon, reference
rs3209162 -- 6,800,760(-) TCACC(C/G)ACAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TEKT1 Gene

Variant ID Type Subtype PubMed ID
nsv907630 CNV Gain 21882294
esv2422288 CNV Deletion 17116639

Relevant External Links for TEKT1 Gene

HapMap Linkage Disequilibrium report
TEKT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT1 Gene

Disorders for TEKT1 Gene

Relevant External Links for TEKT1

Genetic Association Database (GAD)
TEKT1
Human Genome Epidemiology (HuGE) Navigator
TEKT1
genes like me logo Genes that share disorders with TEKT1: view

No data available for UniProtKB/Swiss-Prot for TEKT1 Gene

Publications for TEKT1 Gene

  1. Cloning and characterization of a novel human TEKTIN1 gene. (PMID: 11606253) Xu M. … Mao Y. (Int. J. Biochem. Cell Biol. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PMID: 20442750) Newby P.R. … Gough S.C. (Eur. J. Hum. Genet. 2010) 3 48
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for TEKT1 Gene

Sources for TEKT1 Gene

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