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Aliases for TEKT1 Gene

Aliases for TEKT1 Gene

  • Tektin 1 2 3 5
  • Tektin-1 3

External Ids for TEKT1 Gene

Previous GeneCards Identifiers for TEKT1 Gene

  • GC17M007092
  • GC17M007432
  • GC17M006645
  • GC17M006901
  • GC17M006644
  • GC17M006692

Summaries for TEKT1 Gene

Entrez Gene Summary for TEKT1 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT1 Gene

TEKT1 (Tektin 1) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT1 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Gene Wiki entry for TEKT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT1 Gene

Genomics for TEKT1 Gene

Regulatory Elements for TEKT1 Gene

Enhancers for TEKT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G006853 1.2 Ensembl ENCODE 11.5 -22.9 -22901 2.7 ELF3 ARID4B SIN3A DMAP1 THRB RAD21 ZBTB7B ZBTB40 YY1 ETS1 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 ALOX12P2 GC17M006868
GH17G006867 1 FANTOM5 ENCODE 11.4 -36.8 -36827 2.5 PKNOX1 JUN CEBPG BRCA1 CTBP1 GATA3 RCOR1 FOSL2 FOS KLF8 TEKT1 ALOX12P2 GC17M006868 GC17P006901
GH17G006800 0.6 ENCODE 17 +31.1 31145 0.2 CTCF TEAD4 MAX RAD21 YY1 CREB1 SMC3 RBFOX2 TEKT1 FBXO39
GH17G006668 0.9 ENCODE 10.5 +161.4 161432 3.2 ELF3 NFIB KLF17 THRB ZNF48 RARA IKZF2 EGR2 ZBTB2 NCOA1 SLC13A5 TXNDC17 KIAA0753 FBXO39 TEKT1 BCL6B ENSG00000261996 CTDNEP1 PIR54331 GC17P006673
GH17G006795 1 ENCODE 7.1 +35.1 35054 1.9 FOXA2 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 TCF12 SLC30A9 KLF7 DVL2 NLGN2 SNORD10 MIR497HG ENSG00000262089 SNORA48 TEKT1 FBXO39
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEKT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEKT1 Gene

Chromosome:
17
Start:
6,789,133 bp from pter
End:
6,831,761 bp from pter
Size:
42,629 bases
Orientation:
Minus strand

Genomic View for TEKT1 Gene

Genes around TEKT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT1 Gene

Proteins for TEKT1 Gene

  • Protein details for TEKT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V4-TEKT1_HUMAN
    Recommended name:
    Tektin-1
    Protein Accession:
    Q969V4
    Secondary Accessions:
    • D3DTM7

    Protein attributes for TEKT1 Gene

    Size:
    418 amino acids
    Molecular mass:
    48283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT1 Gene

Post-translational modifications for TEKT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT1 Gene

No data available for DME Specific Peptides for TEKT1 Gene

Domains & Families for TEKT1 Gene

Gene Families for TEKT1 Gene

Protein Domains for TEKT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V4

UniProtKB/Swiss-Prot:

TEKT1_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT1: view

Function for TEKT1 Gene

Molecular function for TEKT1 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Gene Ontology (GO) - Molecular Function for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT1: view
genes like me logo Genes that share phenotypes with TEKT1: view

Animal Model Products

CRISPR Products

miRNA for TEKT1 Gene

miRTarBase miRNAs that target TEKT1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEKT1 Gene

Localization for TEKT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TEKT1: view

Pathways & Interactions for TEKT1 Gene

SuperPathways for TEKT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility IBA --
GO:0060271 cilium assembly IBA --
GO:0060294 cilium movement involved in cell motility IBA --
genes like me logo Genes that share ontologies with TEKT1: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT1 Gene

Drugs & Compounds for TEKT1 Gene

No Compound Related Data Available

Transcripts for TEKT1 Gene

Unigene Clusters for TEKT1 Gene

Tektin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT1 Gene

No ASD Table

Relevant External Links for TEKT1 Gene

GeneLoc Exon Structure for
TEKT1
ECgene alternative splicing isoforms for
TEKT1

Expression for TEKT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEKT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT1 Gene

This gene is overexpressed in Testis (x16.4), Fallopian Tube (x7.4), Brain - Hypothalamus (x4.8), and Cervix - Endocervix (x4.7).

Protein differential expression in normal tissues from HIPED for TEKT1 Gene

This gene is overexpressed in Esophagus (47.0), Heart (8.3), and Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT1 Gene



Protein tissue co-expression partners for TEKT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEKT1 Gene:

TEKT1

SOURCE GeneReport for Unigene cluster for TEKT1 Gene:

Hs.462108

mRNA Expression by UniProt/SwissProt for TEKT1 Gene:

Q969V4-TEKT1_HUMAN
Tissue specificity: Predominantly expressed in testis.

Evidence on tissue expression from TISSUES for TEKT1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT1 Gene

Orthologs for TEKT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT1 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia TEKT1 34 35
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Tekt1 34
  • 81.82 (n)
mouse
(Mus musculus)
Mammalia Tekt1 34 16 35
  • 81.74 (n)
dog
(Canis familiaris)
Mammalia TEKT1 34 35
  • 81.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT1 34 35
  • 66.42 (n)
lizard
(Anolis carolinensis)
Reptilia TEKT1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt1 34
  • 65.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30012 34
zebrafish
(Danio rerio)
Actinopterygii tekt1 34 35
  • 57.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tektin-C 36 34
  • 46.8 (n)
Tektin-A 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007334 34
  • 46.8 (n)
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 34
  • 41.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9917 35
  • 56 (a)
OneToOne
Species where no ortholog for TEKT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT1 Gene

ENSEMBL:
Gene Tree for TEKT1 (if available)
TreeFam:
Gene Tree for TEKT1 (if available)

Paralogs for TEKT1 Gene

Paralogs for TEKT1 Gene

(5) SIMAP similar genes for TEKT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TEKT1: view

Variants for TEKT1 Gene

Sequence variations from dbSNP and Humsavar for TEKT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000010783 -- 6,826,105(+) TCTCC(G/T)TTCTT intron-variant
rs1000047301 -- 6,829,372(+) AATCC(A/G)TGGAT intron-variant
rs1000069478 -- 6,811,690(+) GGACA(C/G)GGATT intron-variant
rs1000145490 -- 6,828,903(+) TCCCA(C/G)ACTTT intron-variant
rs1000155024 -- 6,830,058(+) AGAAC(C/T)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2761942 CNV gain 21179565
esv3572387 CNV gain 25503493
esv3639846 CNV loss 21293372
nsv1059072 CNV loss 25217958

Variation tolerance for TEKT1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEKT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT1 Gene

Disorders for TEKT1 Gene

Relevant External Links for TEKT1

Genetic Association Database (GAD)
TEKT1
Human Genome Epidemiology (HuGE) Navigator
TEKT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEKT1

No disorders were found for TEKT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT1 Gene

Publications for TEKT1 Gene

  1. Cloning and characterization of a novel human TEKTIN1 gene. (PMID: 11606253) Xu M. … Mao Y. (Int. J. Biochem. Cell Biol. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PMID: 20442750) Newby P.R. … Gough S.C. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 64

Products for TEKT1 Gene

Sources for TEKT1 Gene

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