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Aliases for TEKT1 Gene

Aliases for TEKT1 Gene

  • Tektin 1 2 3 5

External Ids for TEKT1 Gene

Previous GeneCards Identifiers for TEKT1 Gene

  • GC17M007092
  • GC17M007432
  • GC17M006645
  • GC17M006901
  • GC17M006644
  • GC17M006692

Summaries for TEKT1 Gene

Entrez Gene Summary for TEKT1 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT1 Gene

TEKT1 (Tektin 1) is a Protein Coding gene. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot for TEKT1 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Gene Wiki entry for TEKT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEKT1 Gene

Genomics for TEKT1 Gene

Regulatory Elements for TEKT1 Gene

Enhancers for TEKT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TEKT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEKT1 Gene

6,789,133 bp from pter
6,831,761 bp from pter
42,629 bases
Minus strand

Genomic View for TEKT1 Gene

Genes around TEKT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT1 Gene

Proteins for TEKT1 Gene

  • Protein details for TEKT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DTM7

    Protein attributes for TEKT1 Gene

    418 amino acids
    Molecular mass:
    48283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT1 Gene

Proteomics data for TEKT1 Gene at MOPED

Post-translational modifications for TEKT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT1 Gene

No data available for DME Specific Peptides for TEKT1 Gene

Domains & Families for TEKT1 Gene

Gene Families for TEKT1 Gene

Protein Domains for TEKT1 Gene


Suggested Antigen Peptide Sequences for TEKT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tektin family.
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT1: view

Function for TEKT1 Gene

Molecular function for TEKT1 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
genes like me logo Genes that share phenotypes with TEKT1: view

Animal Model Products

miRNA for TEKT1 Gene

miRTarBase miRNAs that target TEKT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEKT1 Gene

Localization for TEKT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

Jensen Localization Image for TEKT1 Gene COMPARTMENTS Subcellular localization image for TEKT1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IEA --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with TEKT1: view

Pathways & Interactions for TEKT1 Gene

SuperPathways for TEKT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TEKT1 Gene

Drugs & Compounds for TEKT1 Gene

No Compound Related Data Available

Transcripts for TEKT1 Gene

Unigene Clusters for TEKT1 Gene

Tektin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT1 Gene

No ASD Table

Relevant External Links for TEKT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEKT1 Gene

mRNA expression in normal human tissues for TEKT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT1 Gene

This gene is overexpressed in Testis (x16.4), Fallopian Tube (x7.4), Brain - Hypothalamus (x4.8), and Cervix - Endocervix (x4.7).

Protein differential expression in normal tissues from HIPED for TEKT1 Gene

This gene is overexpressed in Esophagus (47.0), Heart (8.3), and Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEKT1 Gene

SOURCE GeneReport for Unigene cluster for TEKT1 Gene Hs.462108

mRNA Expression by UniProt/SwissProt for TEKT1 Gene

Tissue specificity: Predominantly expressed in testis.
genes like me logo Genes that share expression patterns with TEKT1: view

Protein tissue co-expression partners for TEKT1 Gene

Primer Products

Orthologs for TEKT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TEKT1 35
  • 87.08 (n)
  • 86.36 (a)
TEKT1 36
  • 86 (a)
(Canis familiaris)
Mammalia TEKT1 35
  • 81.64 (n)
  • 82.37 (a)
TEKT1 36
  • 81 (a)
(Mus musculus)
Mammalia Tekt1 35
  • 81.74 (n)
  • 82.54 (a)
Tekt1 16
Tekt1 36
  • 83 (a)
(Pan troglodytes)
Mammalia TEKT1 35
  • 99.2 (n)
  • 98.8 (a)
TEKT1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tekt1 35
  • 81.82 (n)
  • 82.78 (a)
(Ornithorhynchus anatinus)
Mammalia TEKT1 36
  • 71 (a)
(Gallus gallus)
Aves TEKT1 35
  • 66.42 (n)
  • 64.59 (a)
TEKT1 36
  • 65 (a)
(Anolis carolinensis)
Reptilia TEKT1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt1 35
  • 65.5 (n)
  • 68.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30012 35
(Danio rerio)
Actinopterygii tekt1 35
  • 57.74 (n)
  • 48.23 (a)
tekt1 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tektin-A 37
  • 30 (a)
Tektin-C 37
  • 32 (a)
Tektin-C 35
  • 46.8 (n)
  • 31.82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007334 35
  • 46.8 (n)
  • 33.59 (a)
(Caenorhabditis elegans)
Secernentea R02E12.4 35
  • 41.67 (n)
  • 26.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9917 36
  • 56 (a)
Species with no ortholog for TEKT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT1 Gene

Gene Tree for TEKT1 (if available)
Gene Tree for TEKT1 (if available)

Paralogs for TEKT1 Gene

Paralogs for TEKT1 Gene

(5) SIMAP similar genes for TEKT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TEKT1: view

Variants for TEKT1 Gene

Sequence variations from dbSNP and Humsavar for TEKT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3744395 - 6,812,923(+) CTTGC(A/G)CAGAT reference, missense
rs2271233 - 6,800,802(+) TGCGA(C/T)ATCAC intron-variant, reference, missense
rs34431552 - 6,815,883(-) AGGGC(A/G)TTATG reference, missense
rs1228492 -- 6,829,756(-) AGATT(A/T)CAACA intron-variant
rs2136282 -- 6,800,954(+) AAAAA(A/C/G)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEKT1 Gene

Variant ID Type Subtype PubMed ID
nsv907630 CNV Gain 21882294
esv2422288 CNV Deletion 17116639

Variation tolerance for TEKT1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TEKT1 Gene

Disorders for TEKT1 Gene

Relevant External Links for TEKT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TEKT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEKT1 Gene

Publications for TEKT1 Gene

  1. Cloning and characterization of a novel human TEKTIN1 gene. (PMID: 11606253) Xu M. … Mao Y. (Int. J. Biochem. Cell Biol. 2001) 2 3 4 67
  2. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TEKT1 Gene

Sources for TEKT1 Gene