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TEKT1 Gene

protein-coding   GIFtS: 51
GCID: GC17M006692

Tektin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tektin 11 2
tektin-12

External Ids:    HGNC: 155341   Entrez Gene: 836592   Ensembl: ENSG000001678587   OMIM: 6090025   UniProtKB: Q969V43   

Export aliases for TEKT1 gene to outside databases

Previous GC identifers: GC17M007092 GC17M007432 GC17M006645 GC17M006901 GC17M006644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEKT1 Gene:
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins
that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly
expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in
the seminiferous tubules, indicating that it may play a role in spermatogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEKT1 Gene:
TEKT1 (tektin 1) is a protein-coding gene. Diseases associated with TEKT1 include graves' disease, and malaria. An important paralog of this gene is ENSG00000215615.

UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4
Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
ciliary and flagellar microtubules

Gene Wiki entry for TEKT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEKT1 gene promoter:
         ISGF-3   AML1a   NF-AT   S8   NF-AT4   NF-AT2   FOXO4   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEKT1 promoter sequence
   Search Chromatin IP Primers for TEKT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEKT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

TEKT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEKT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006692:  view genomic region     (about GC identifiers)

Start:
6,692,452 bp from pter      End:
6,735,080 bp from pter
Size:
42,629 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4 (See protein sequence)
Recommended Name: Tektin-1  
Size: 418 amino acids; 48283 Da
Secondary accessions: D3DTM7

Explore the universe of human proteins at neXtProt for TEKT1: NX_Q969V4

Explore proteomics data for TEKT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEKT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_444515.1  
    ENSEMBL proteins: 
     ENSP00000460197   ENSP00000341346   ENSP00000460359   ENSP00000458518   ENSP00000444142  

    TEKT1 Human Recombinant Protein Products:

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    Novus Biologicals TEKT1 Lysates
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    Cloud-Clone Corp. Proteins for TEKT1

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    Cloud-Clone Corp. CLIAs for TEKT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000435 Tektin

    Graphical View of Domain Structure for InterPro Entry Q969V4

    ProtoNet protein and cluster: Q969V4

    1 Blocks protein domain: IPB000435 Tektin signature

    UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4
    Similarity: Belongs to the tektin family


    TEKT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEKT1_HUMAN, Q969V4
    Function: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of
    ciliary and flagellar microtubules

    Phenotypes:
         1 GenomeRNAi human phenotype for TEKT1:

     Bright nuclei 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEKT1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEKT1

    miRNA
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    miRTarBase miRNAs that target TEKT1:
    hsa-mir-335-5p (MIRT017741)

    Block miRNA regulation of human, mouse, rat TEKT1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TEKT1:
    hsa-miR-580
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TEKT1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEKT1_HUMAN, Q969V4: Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005929cilium IEA--

    TEKT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEKT1
    Interactions:

        Search GeneGlobe Interaction Network for TEKT1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TEKT1 (ENSP000003413464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TDRD1ENSP000002518644STRING: ENSP00000251864
    FAM109AENSP000003544614STRING: ENSP00000354461
    FAM109BENSP000003127534STRING: ENSP00000312753
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--

    TEKT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEKT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEKT1 gene: 
    NM_053285.1  

    Unigene Cluster for TEKT1:

    Tektin 1
    Hs.462108  [show with all ESTs]
    Unigene Representative Sequence: AK094836
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571744 ENST00000338694(uc002gdt.3) ENST00000575592(uc010vth.2)
    ENST00000572291 ENST00000573966 ENST00000535086
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TEKT1:
    hsa-miR-580
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TEKT1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEKT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEKT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TEKT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TEKT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEKT1
      QuantiTect SYBR Green Assays in human, mouse, rat TEKT1
      QuantiFast Probe-based Assays in human, mouse, rat TEKT1

    Additional mRNA sequence: 

    AF357879.1 AK094836.1 AK292818.1 AK304345.1 BC014599.2 

    3 DOTS entries:

    DT.101231  DT.95201810  DT.95366672 

    Selected AceView cDNA sequences (see all 50):

    BM973832 BM725244 AA994630 BC014599 BM677689 T17287 AI219651 BG545924 
    BU684424 NM_053285 BM973153 CA450315 AF357879 BI831036 BP369443 BG702745 
    BP369233 BP369998 BX104988 AA813745 BP370295 BI830979 BP369033 AI554187 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEKT1 expression in normal human tissues (normalized intensities)      TEKT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTCTGGGC
    TEKT1 Expression
    About this image


    TEKT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
    TEKT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEKT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462108

    UniProtKB/Swiss-Prot: TEKT1_HUMAN, Q969V4
    Tissue specificity: Predominantly expressed in testis

        Custom PCR Arrays for TEKT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEKT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEKT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tekt11 , 5 tektin 11, 5 81.74(n)1
    82.54(a)1
      11 (44.03 cM)5
    216891  NM_001282007.11  NP_001268936.11 
     723447225 
    chicken
    (Gallus gallus)
    Aves TEKT11 tektin 1 66.42(n)
    64.59(a)
      417686  XM_004946829.1  XP_004946886.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEKT16
    tektin 1
    62(a)
    1 ↔ 1
    GL344820.1(17148-20164)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.300122 Xenopus laevis transcribed sequence with moderate similarity more 71.28(n)    BJ050015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tekt11 tektin 1 57.74(n)
    48.23(a)
      492525  NM_001007397.1  NP_001007398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tektin-C1 , 3 microtubule-based process microtubule
    binding3
    Tektin C1
    32(a)
    (best of 2)3
    46.8(n)1
    31.82(a)1
      64E83
    386531  NM_001104050.21  NP_001097520.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R02E12.41 R02E12.4 41.67(n)
    26.42(a)
      187525  NM_076288.1  NP_508689.1 


    ENSEMBL Gene Tree for TEKT1 (if available)
    TreeFam Gene Tree for TEKT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEKT1 gene
    ENSG000002156152  TEKT42  TEKT22  TEKT52  ENSG000002157502  TEKT32  
    5 SIMAP similar genes for TEKT1 using alignment to 5 protein entries:     TEKT1_HUMAN (see all proteins):
    TEKT5    LOC389833    TEKT3    TEKT4    TEKT2

    TEKT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEKT1 (see all 886)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486560211,2
    C,Funtested16718542(+) TGAGCG/AAGAAG 2 /S /L mis12Minor allele frequency- A:0.01NA EU 5875
    rs557165501,2
    C--6702807(+) AGTGGG/AGACTA 1 -- ds50013Minor allele frequency- A:0.16WA NA 240
    rs788187911,2
    F--6702816(+) TATTGG/AAGGTC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs72128421,2
    C,F,A,H--6702837(+) ATGGCG/AGACTC 1 -- ds5001 ese326Minor allele frequency- A:0.37NA NS EA WA CSA 2484
    rs2015358601,2
    C--6702935(+) TAAGA-/AAAAAA 1 -- ds50010--------
    rs1822923921,2
    --6702985(+) AAGAGA/GAAGGT 1 -- ds50010--------
    rs99046651,2
    C,F,A,H--6703183(+) TAAGAA/GAAGAA 1 -- ds5001 trp326Minor allele frequency- G:0.41NA NS EA WA CSA 2497
    rs1477407511,2
    C--6703216(+) TGAGCA/GGGCTT 1 -- ds50010--------
    rs2004879741,2
    C--6703323(+) TTAATA/GAGAAT 1 -- ut310--------
    rs1994984721,2
    --6703366(+) AGGGCA/GGAGGC 2 R C mis10--------

    HapMap Linkage Disequilibrium report for TEKT1 (6692452 - 6735080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TEKT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv907630CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEKT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TEKT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609002    OMIM disorders: --

    3 diseases for TEKT1:    About MalaCards
    graves' disease    malaria    endotheliitis


    TEKT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TEKT1
    Human Genome Epidemiology (HuGE) Navigator: TEKT1 (2 documents)

    Export disorders for TEKT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEKT1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TEKT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human TEKTIN1 gene. (PubMed id 11606253)1, 2, 3 Xu M.... Mao Y. (Int. J. Biochem. Cell Biol. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PubMed id 20442750)1, 4 Newby P.R....Gough S.C. (Eur. J. Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Cloning and characterization of the human tektin-t gene. (PubMed id 12029069)1 Iguchi N....Nishimune Y. (Mol. Hum. Reprod. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83659 HGNC: 15534 AceView: TEKT1 Ensembl:ENSG00000167858 euGenes: HUgn83659
    ECgene: TEKT1 H-InvDB: TEKT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEKT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEKT1 gene:
    Search GeneIP for patents involving TEKT1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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