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Aliases for TEK Gene

Aliases for TEK Gene

  • TEK Tyrosine Kinase, Endothelial 2 3
  • VMCM 3 4 6
  • TIE2 3 4 6
  • Tyrosine Kinase With Ig And EGF Homology Domains-2 3 4
  • Tunica Interna Endothelial Cell Kinase 3 4
  • Tyrosine-Protein Kinase Receptor TIE-2 3 4
  • Tyrosine-Protein Kinase Receptor TEK 3 4
  • Endothelial Tyrosine Kinase 3 4
  • EC 2.7.10.1 4 64
  • VMCM1 3 4
  • Venous Malformations, Multiple Cutaneous And Mucosal 2
  • Angiopoietin-1 Receptor 3
  • CD202b Antigen 4
  • EC 2.7.10 64
  • P140 TEK 4
  • CD202B 3
  • TIE-2 3
  • HTIE2 4

External Ids for TEK Gene

Previous Symbols for TEK Gene

  • VMCM

Summaries for TEK Gene

Entrez Gene Summary for TEK Gene

  • This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

GeneCards Summary for TEK Gene

TEK (TEK Tyrosine Kinase, Endothelial) is a Protein Coding gene. Diseases associated with TEK include venous malformations, multiple cutaneous and mucosal and intramuscular hemangioma. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include receptor activity and protein tyrosine kinase activity. An important paralog of this gene is STYK1.

UniProtKB/Swiss-Prot for TEK Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.

Gene Wiki entry for TEK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEK Gene

Genomics for TEK Gene

Genomic Location for TEK Gene

Start:
27,109,141 bp from pter
End:
27,230,175 bp from pter
Size:
121,035 bases
Orientation:
Plus strand

Genomic View for TEK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEK Gene

Regulatory Elements for TEK Gene

Proteins for TEK Gene

  • Protein details for TEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02763-TIE2_HUMAN
    Recommended name:
    Angiopoietin-1 receptor
    Protein Accession:
    Q02763
    Secondary Accessions:
    • A8K6W0
    • B4DH20
    • B4DHD3
    • D3DRK5
    • E7EWI2
    • Q5TCU2
    • Q8IV34

    Protein attributes for TEK Gene

    Size:
    1124 amino acids
    Molecular mass:
    125830 Da
    Quaternary structure:
    • Homodimer. Heterodimer with TIE1. Interacts with ANGPT1, ANGPT2 and ANGPT4. At cell-cell contacts in quiescent cells, forms a signaling complex composed of ANGPT1 plus TEK molecules from two adjoining cells. In the absence of endothelial cell-cell contacts, interaction with ANGPT1 mediates contacts with the extracellular matrix. Interacts with PTPRB; this promotes endothelial cell-cell adhesion. Interacts with DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2. Colocalizes with DOK2 at contacts with the extracellular matrix in migrating cells. Interacts (tyrosine phosphorylated) with TNIP2. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain).

    Three dimensional structures from OCA and Proteopedia for TEK Gene

    Alternative splice isoforms for TEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEK Gene

Proteomics data for TEK Gene at MOPED

Post-translational modifications for TEK Gene

  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-992 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at Tyr-1108 and at additional tyrosine residues. ANGPT1-induced phosphorylation is impaired during hypoxia, due to increased expression of ANGPT2. Phosphorylation is important for interaction with GRB14, PIK3R1 and PTPN11. Phosphorylation at Tyr-1102 is important for interaction with SHC1, GRB2 and GRB7. Phosphorylation at Tyr-1108 is important for interaction with DOK2 and for coupling to downstream signal transduction pathways in endothelial cells. Dephosphorylated by PTPRB.
  • Proteolytic processing leads to the shedding of the extracellular domain (soluble TIE-2 alias sTIE-2).
  • Ubiquitinated. The phosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn140, Asn158, Asn399, Asn438, Asn464, Asn560, Asn596, Asn649, and Asn691

Other Protein References for TEK Gene

Domains for TEK Gene

Gene Families for TEK Gene

HGNC:
  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

TIE2_HUMAN
Domain:
  • The soluble extracellular domain is functionally active in angiopoietin binding and can modulate the activity of the membrane-bound form by competing for angiopoietins.:
    • Q02763
  • Contains 3 EGF-like domains.:
    • Q02763
  • Contains 3 fibronectin type-III domains.:
    • Q02763
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q02763
  • Contains 1 protein kinase domain.:
    • Q02763
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.:
    • Q02763
genes like me logo Genes that share domains with TEK: view

Function for TEK Gene

Molecular function for TEK Gene

GENATLAS Biochemistry: endothelial cell specific receptor tyrosine kinase,with extracellular immunoglobulin,epidermal growth factor,fibronectin-type III homology domains,involved in angiogenesis (in maintenance and/or remodeling of the adult vasculature)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-992 on the kinase activation loop. Inhibited by staurosporine, K252a, PP2, damnacanthal, SB203580, CEP-11207, CEP-11981 and CE-245677. Inhibited by triazine, thienopyrimidine and thiazolopyrimidine derivatives.
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.

Enzyme Numbers (IUBMB) for TEK Gene

Gene Ontology (GO) - Molecular Function for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8382358
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0004872 receptor activity TAS 10766762
GO:0005515 protein binding IPI 19167335
genes like me logo Genes that share ontologies with TEK: view
genes like me logo Genes that share phenotypes with TEK: view

Animal Models for TEK Gene

MGI Knock Outs for TEK:

miRNA for TEK Gene

miRTarBase miRNAs that target TEK

No data available for Transcription Factor Targeting and HOMER Transcription for TEK Gene

Localization for TEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEK Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEK Gene COMPARTMENTS Subcellular localization image for TEK gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IDA 18425119
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm --
GO:0005884 colocalizes_with actin filament IDA 18425119
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TEK: view

Pathways for TEK Gene

genes like me logo Genes that share pathways with TEK: view

Pathways by source for TEK Gene

Gene Ontology (GO) - Biological Process for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001666 response to hypoxia IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 18425120
GO:0001935 endothelial cell proliferation ISS --
GO:0001938 positive regulation of endothelial cell proliferation TAS 18425120
genes like me logo Genes that share ontologies with TEK: view

Compounds for TEK Gene

(2) HMDB Compounds for TEK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Drugbank Compounds for TEK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
target
Ponatinib
943319-70-8 target inhibitor
Regorafenib
755037-03-7 target inhibitor
Vandetanib
  • 4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
443913-73-3 target inhibitor

(2) IUPHAR Ligand for TEK Gene

Ligand Type Action Affinity Pubmed IDs
angiopoietin-4 None None
angiopoietin-1 None None

(16) Novoseek inferred chemical compound relationships for TEK Gene

Compound -log(P) Hits PubMed IDs
vegf 84.1 191
tyrosine 75.7 106
matrigel 51.7 4
tween 33.5 2
phosphatidylinositol 18.9 4
genes like me logo Genes that share compounds with TEK: view

Transcripts for TEK Gene

Unigene Clusters for TEK Gene

TEK tyrosine kinase, endothelial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2: -
SP3:

Relevant External Links for TEK Gene

GeneLoc Exon Structure for
TEK
ECgene alternative splicing isoforms for
TEK

Expression for TEK Gene

mRNA expression in normal human tissues for TEK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEK Gene

SOURCE GeneReport for Unigene cluster for TEK Gene Hs.89640

mRNA Expression by UniProt/SwissProt for TEK Gene

Q02763-TIE2_HUMAN
Tissue specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
genes like me logo Genes that share expressions with TEK: view

Orthologs for TEK Gene

This gene was present in the common ancestor of animals.

Orthologs for TEK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEK 36
  • 96.59 (n)
  • 96.17 (a)
TEK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEK 36
  • 91.04 (n)
  • 95.37 (a)
TEK 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEK 36
  • 91.9 (n)
  • 95.91 (a)
TEK 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tek 36
  • 88.95 (n)
  • 93.14 (a)
Tek 16
Tek 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEK 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEK 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tek 36
  • 89.4 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves TEK 36
  • 71.62 (n)
  • 74 (a)
TEK 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEK 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398263 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15681 36
tek 36
  • 66.22 (n)
  • 67.38 (a)
zebrafish
(Danio rerio)
Actinopterygii tek 36
  • 57.18 (n)
  • 54.29 (a)
tek 37
  • 53 (a)
OneToOne
tie2 36
fruit fly
(Drosophila melanogaster)
Insecta Tie 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-30 37
  • 24 (a)
ManyToMany
T22B11.3 37
  • 22 (a)
ManyToMany
R151.4 38
  • 38 (a)
R09D1.13 38
  • 31 (a)
kin-9 38
  • 37 (a)
F09G2.1 38
  • 31 (a)
Y38H6C.20 38
  • 30 (a)
old-1 38
  • 29 (a)
Y50D4B.6 38
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for TEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEK Gene

ENSEMBL:
Gene Tree for TEK (if available)
TreeFam:
Gene Tree for TEK (if available)

Paralogs for TEK Gene

Paralogs for TEK Gene

Selected SIMAP similar genes for TEK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TEK: view

Variants for TEK Gene

Sequence variations from dbSNP and Humsavar for TEK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs857 -- 27,229,788(+) GTCCC(A/C/G)TTTCA utr-variant-3-prime
rs1049 -- 27,229,776(+) CTGTA(A/G)CATGC utr-variant-3-prime
rs472647 -- 27,158,166(-) CACCT(C/G)CCCAA intron-variant
rs473205 -- 27,222,186(+) aaaaa(A/G)taatg intron-variant
rs474135 -- 27,222,284(+) aaaac(A/C)ctctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEK Gene

Variant ID Type Subtype PubMed ID
nsv517269 CNV Gain 19592680
nsv892862 CNV Gain 21882294
nsv892863 CNV Gain 21882294
nsv6512 CNV Loss 18451855
nsv892864 CNV Gain 21882294
esv1009235 CNV Deletion 20482838
nsv466336 CNV Gain 19166990
nsv471294 CNV Gain 18288195
esv23509 CNV Gain 19812545
nsv824895 CNV Loss 20364138
nsv892865 CNV Gain 21882294

Relevant External Links for TEK Gene

HapMap Linkage Disequilibrium report
TEK
Human Gene Mutation Database (HGMD)
TEK

Disorders for TEK Gene

(1) OMIM Diseases for TEK Gene (600221)

UniProtKB/Swiss-Prot

TIE2_HUMAN
  • Dominantly inherited venous malformations (VMCM) [MIM:600195]: An error of vascular morphogenesis characterized by dilated, serpiginous channels. {ECO:0000269 PubMed:10369874, ECO:0000269 PubMed:19888299, ECO:0000269 PubMed:8980225}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=May play a role in a range of diseases with a vascular component, including neovascularization of tumors, psoriasis and inflammation.

(65) Novoseek inferred disease relationships for TEK Gene

Disease -log(P) Hits PubMed IDs
neovascularization 74.6 18
malformation venous 71.5 12
tumors 48.7 110
inflammatory breast cancer 48.1 2
corneal neovascularization 35.6 1

Relevant External Links for TEK

GeneTests
TEK
GeneReviews
TEK
Genetic Association Database (GAD)
TEK
Human Genome Epidemiology (HuGE) Navigator
TEK
genes like me logo Genes that share disorders with TEK: view

Publications for TEK Gene

  1. Allelic and locus heterogeneity in inherited venous malformations. (PMID: 10369874) Calvert J.T. … Marchuk D.A. (Hum. Mol. Genet. 1999) 3 4 23
  2. Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. (PMID: 11080633) Shewchuk L.M. … Moore J.T. (Structure 2000) 3 4 23
  3. Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. (PMID: 8382358) Ziegler S.F. … Baum P.R. (Oncogene 1993) 3 4 23
  4. Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho- Tie2. (PMID: 11513602) Murray B.W. … McTigue M.A. (Biochemistry 2001) 3 4 23
  5. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. (PMID: 12609966) Hughes D.P. … Brindle N.P. (Circ. Res. 2003) 3 4 23

Products for TEK Gene

Sources for TEK Gene

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