Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEK Gene

Aliases for TEK Gene

  • TEK Receptor Tyrosine Kinase 2 3
  • TEK Tyrosine Kinase, Endothelial 2 3 5
  • Tyrosine Kinase With Ig And EGF Homology Domains-2 3 4
  • Tunica Interna Endothelial Cell Kinase 3 4
  • Tyrosine-Protein Kinase Receptor TIE-2 3 4
  • Tyrosine-Protein Kinase Receptor TEK 3 4
  • Endothelial Tyrosine Kinase 3 4
  • EC 2.7.10.1 4 63
  • VMCM1 3 4
  • VMCM 3 4
  • TIE2 3 4
  • Venous Malformations, Multiple Cutaneous And Mucosal 2
  • CD202b Antigen 4
  • EC 2.7.10 63
  • P140 TEK 4
  • CD202B 3
  • TIE-2 3
  • HTIE2 4

External Ids for TEK Gene

Previous HGNC Symbols for TEK Gene

  • VMCM

Previous GeneCards Identifiers for TEK Gene

  • GC09P027421
  • GC09P027278
  • GC09P027099

Summaries for TEK Gene

Entrez Gene Summary for TEK Gene

  • This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

GeneCards Summary for TEK Gene

TEK (TEK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TEK include Venous Malformations, Multiple Cutaneous And Mucosal and Pyogenic Granuloma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STYK1.

UniProtKB/Swiss-Prot for TEK Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.

Gene Wiki entry for TEK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEK Gene

Genomics for TEK Gene

Regulatory Elements for TEK Gene

Enhancers for TEK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TEK on UCSC Golden Path with GeneCards custom track

Promoters for TEK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TEK on UCSC Golden Path with GeneCards custom track

Genomic Location for TEK Gene

Chromosome:
9
Start:
27,109,141 bp from pter
End:
27,230,178 bp from pter
Size:
121,038 bases
Orientation:
Plus strand

Genomic View for TEK Gene

Genes around TEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEK Gene

Proteins for TEK Gene

  • Protein details for TEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02763-TIE2_HUMAN
    Recommended name:
    Angiopoietin-1 receptor
    Protein Accession:
    Q02763
    Secondary Accessions:
    • A8K6W0
    • B4DH20
    • B4DHD3
    • D3DRK5
    • E7EWI2
    • Q5TCU2
    • Q8IV34

    Protein attributes for TEK Gene

    Size:
    1124 amino acids
    Molecular mass:
    125830 Da
    Quaternary structure:
    • Homodimer. Heterodimer with TIE1. Interacts with ANGPT1, ANGPT2 and ANGPT4. At cell-cell contacts in quiescent cells, forms a signaling complex composed of ANGPT1 plus TEK molecules from two adjoining cells. In the absence of endothelial cell-cell contacts, interaction with ANGPT1 mediates contacts with the extracellular matrix. Interacts with PTPRB; this promotes endothelial cell-cell adhesion. Interacts with DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2. Colocalizes with DOK2 at contacts with the extracellular matrix in migrating cells. Interacts (tyrosine phosphorylated) with TNIP2. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain).

    Three dimensional structures from OCA and Proteopedia for TEK Gene

    Alternative splice isoforms for TEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEK Gene

Proteomics data for TEK Gene at MOPED

Post-translational modifications for TEK Gene

  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-992 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at Tyr-1108 and at additional tyrosine residues. ANGPT1-induced phosphorylation is impaired during hypoxia, due to increased expression of ANGPT2. Phosphorylation is important for interaction with GRB14, PIK3R1 and PTPN11. Phosphorylation at Tyr-1102 is important for interaction with SHC1, GRB2 and GRB7. Phosphorylation at Tyr-1108 is important for interaction with DOK2 and for coupling to downstream signal transduction pathways in endothelial cells. Dephosphorylated by PTPRB.
  • Proteolytic processing leads to the shedding of the extracellular domain (soluble TIE-2 alias sTIE-2).
  • Ubiquitinated. The phosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
  • Glycosylation at Asn 140, Asn 158, Asn 399, Asn 438, Asn 464, Asn 560, Asn 596, Asn 649, and Asn 691
  • Modification sites at PhosphoSitePlus

Other Protein References for TEK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TEK (TIE2)

Assay Products

  • Cloud-Clone Corp Assay Kits for TEK
  • Abcam assays for TIE2

Domains & Families for TEK Gene

Graphical View of Domain Structure for InterPro Entry

Q02763

UniProtKB/Swiss-Prot:

TIE2_HUMAN :
  • The soluble extracellular domain is functionally active in angiopoietin binding and can modulate the activity of the membrane-bound form by competing for angiopoietins.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Domain:
  • The soluble extracellular domain is functionally active in angiopoietin binding and can modulate the activity of the membrane-bound form by competing for angiopoietins.
  • Contains 3 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TEK: view

Function for TEK Gene

Molecular function for TEK Gene

GENATLAS Biochemistry:
endothelial cell specific receptor tyrosine kinase,with extracellular immunoglobulin,epidermal growth factor,fibronectin-type III homology domains,involved in angiogenesis (in maintenance and/or remodeling of the adult vasculature)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-992 on the kinase activation loop. Inhibited by staurosporine, K252a, PP2, damnacanthal, SB203580, CEP-11207, CEP-11981 and CE-245677. Inhibited by triazine, thienopyrimidine and thiazolopyrimidine derivatives.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.

Enzyme Numbers (IUBMB) for TEK Gene

Gene Ontology (GO) - Molecular Function for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with TEK: view
genes like me logo Genes that share phenotypes with TEK: view

Human Phenotype Ontology for TEK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEK Gene

MGI Knock Outs for TEK:
  • Tek tm1Sato
  • Tek tm1.1(icre/Esr1*)Hrr
  • Tek tm1Dmt

Animal Model Products

miRNA for TEK Gene

miRTarBase miRNAs that target TEK

No data available for Transcription Factor Targets and HOMER Transcription for TEK Gene

Localization for TEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEK Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEK Gene COMPARTMENTS Subcellular localization image for TEK gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IDA 18425119
genes like me logo Genes that share ontologies with TEK: view

Pathways & Interactions for TEK Gene

SuperPathways for TEK Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 GPCR Pathway
3 ERK Signaling
4 Nanog in Mammalian ESC Pluripotency
5 Actin Nucleation by ARP-WASP Complex
genes like me logo Genes that share pathways with TEK: view

SIGNOR curated interactions for TEK Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001525 angiogenesis ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 18425120
GO:0001935 endothelial cell proliferation ISS --
genes like me logo Genes that share ontologies with TEK: view

Drugs & Compounds for TEK Gene

(26) Drugs for TEK Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vandetanib Approved April 2011 Pharma Target, inhibitor VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
regorafenib Approved Pharma inhibitor, Target Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Ampicillin Approved Pharma Target 53
ponatinib Approved Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 30
Cometriq Approved November 2012 Pharma inhibitor, Biomarker RTK, HGFR, VEGFR2, KIT, Flt3, and Tie-2 inhibitor, cMET Inhibitors 0

(8) Additional Compounds for TEK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for TEK Gene

Compound Action Cas Number
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
MGCD-265 Met/Flt/Flk/Ron/Tie-2 inhibitor 875337-44-3
Tie2 kinase inhibitor Tie-2(Tie2 ) inhibitor 948557-43-5
genes like me logo Genes that share compounds with TEK: view

Transcripts for TEK Gene

Unigene Clusters for TEK Gene

TEK tyrosine kinase, endothelial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2: -
SP3:

Relevant External Links for TEK Gene

GeneLoc Exon Structure for
TEK
ECgene alternative splicing isoforms for
TEK

Expression for TEK Gene

mRNA expression in normal human tissues for TEK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TEK Gene

This gene is overexpressed in Placenta (45.8) and Lung (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEK Gene



SOURCE GeneReport for Unigene cluster for TEK Gene Hs.89640

mRNA Expression by UniProt/SwissProt for TEK Gene

Q02763-TIE2_HUMAN
Tissue specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
genes like me logo Genes that share expression patterns with TEK: view

Protein tissue co-expression partners for TEK Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TEK Gene

Orthologs for TEK Gene

This gene was present in the common ancestor of animals.

Orthologs for TEK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEK 35
  • 91.04 (n)
  • 95.37 (a)
TEK 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEK 35
  • 91.9 (n)
  • 95.91 (a)
TEK 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tek 35
  • 88.95 (n)
  • 93.14 (a)
Tek 16
Tek 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEK 35
  • 96.59 (n)
  • 96.17 (a)
TEK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tek 35
  • 89.4 (n)
  • 93.74 (a)
oppossum
(Monodelphis domestica)
Mammalia TEK 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEK 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEK 35
  • 71.62 (n)
  • 74 (a)
TEK 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEK 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15681 35
tek 35
  • 66.22 (n)
  • 67.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398263 35
zebrafish
(Danio rerio)
Actinopterygii tek 35
  • 57.18 (n)
  • 54.29 (a)
tie2 35
tek 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tie 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F09G2.1 37
  • 31 (a)
kin-9 37
  • 37 (a)
old-1 37
  • 29 (a)
R09D1.13 37
  • 31 (a)
R151.4 37
  • 38 (a)
Y38H6C.20 37
  • 30 (a)
Y50D4B.6 37
  • 31 (a)
kin-30 36
  • 24 (a)
ManyToMany
T22B11.3 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEK Gene

ENSEMBL:
Gene Tree for TEK (if available)
TreeFam:
Gene Tree for TEK (if available)

Paralogs for TEK Gene

Paralogs for TEK Gene

genes like me logo Genes that share paralogs with TEK: view

Variants for TEK Gene

Sequence variations from dbSNP and Humsavar for TEK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_006352 Dominantly inherited venous malformations (VMCM)
VAR_008716 Dominantly inherited venous malformations (VMCM)
rs1334811 - 27,190,657(+) AACCC(A/G)TTAAT reference, missense
VAR_035714 Breast cancer samples
rs35969327 - 27,168,573(+) ATTGA(C/T)TAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TEK Gene

Variant ID Type Subtype PubMed ID
nsv517269 CNV Gain 19592680
nsv892862 CNV Gain 21882294
nsv892863 CNV Gain 21882294
nsv6512 CNV Loss 18451855
nsv892864 CNV Gain 21882294
esv1009235 CNV Deletion 20482838
nsv466336 CNV Gain 19166990
nsv471294 CNV Gain 18288195
esv23509 CNV Gain 19812545
nsv824895 CNV Loss 20364138
nsv892865 CNV Gain 21882294

Variation tolerance for TEK Gene

Residual Variation Intolerance Score: 7.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEK Gene

Human Gene Mutation Database (HGMD)
TEK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEK Gene

Disorders for TEK Gene

MalaCards: The human disease database

(24) MalaCards diseases for TEK Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
venous malformations, multiple cutaneous and mucosal
  • multiple cutaneous and mucosal venous malformations
pyogenic granuloma
  • lobular capillary hemangioma
capillary hemangioma
  • cellular hemangioma of infancy
intramuscular hemangioma
  • intramuscular angioma
glomangioma
- elite association - COSMIC cancer census association via MalaCards
Search TEK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TIE2_HUMAN
  • Dominantly inherited venous malformations (VMCM) [MIM:600195]: An error of vascular morphogenesis characterized by dilated, serpiginous channels. {ECO:0000269 PubMed:10369874, ECO:0000269 PubMed:19888299, ECO:0000269 PubMed:8980225}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=May play a role in a range of diseases with a vascular component, including neovascularization of tumors, psoriasis and inflammation.

Relevant External Links for TEK

Genetic Association Database (GAD)
TEK
Human Genome Epidemiology (HuGE) Navigator
TEK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEK
genes like me logo Genes that share disorders with TEK: view

No data available for Genatlas for TEK Gene

Publications for TEK Gene

  1. Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho- Tie2. (PMID: 11513602) Murray B.W. … McTigue M.A. (Biochemistry 2001) 3 4 23 67
  2. The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients. (PMID: 19543148) van der Heijden M. … Groeneveld A.B. (Shock 2010) 3 23
  3. Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. (PMID: 19922791) Hansen T.M. … Brindle N.P. (Cell. Signal. 2010) 3 23
  4. A negative regulatory role for Y1111 on the Tie-2 RTK. (PMID: 20026268) Sturk C. … Dumont D.J. (Cell. Signal. 2010) 3 23
  5. An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells. (PMID: 20056911) Onimaru M. … Sueishi K. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 23

Products for TEK Gene

Sources for TEK Gene

Content