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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEF Gene

protein-coding   GIFtS: 54
GCID: GC22P041763

thyrotrophic embryonic factor

 Explore 21 diseases affiliated with
TEF via our new
 Human Malady Compendium 
Biological research products
for TEF
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thyrotrophic Embryonic Factor1 2
KIAA16551 3
Thyrotroph Embryonic Factor2

External Ids:    HGNC: 117221   Entrez Gene: 70082   Ensembl: ENSG000001670747   OMIM: 1885955   UniProtKB: Q105873   

Export aliases for TEF gene to outside databases

Previous GC identifers: GC22P038392 GC22P040006 GC22P040021 GC22P040102 GC22P024729


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TEF:
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper
(bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during
embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident
with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB
promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription
factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken
vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the
subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587
Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding
sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'

Gene Wiki entry for TEF


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEF gene promoter:
         CREB   AhR   p53   AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TEF promoter sequence
   Search SABiosciences Chromatin IP Primers for TEF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

TEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P041763:  view genomic region     (about GC identifiers)

Start:
41,763,337 bp from pter      End:
41,795,330 bp from pter
Size:
31,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587 (See protein sequence)
Recommended Name: Thyrotroph embryonic factor  
Size: 303 amino acids; 33248 Da
Subunit: Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP
Subcellular location: Nucleus
Sequence caution: Sequence=AAA81373.1; Type=Erroneous initiation;
Secondary accessions: B0QYS8 B2RC22 Q15729 Q7Z3J7 Q8IU94 Q96TG4
Alternative splicing: 2 isoforms:  Q10587-1   Q10587-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEF: NX_Q10587

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q10587

  • TEF Protein expression data from MOPED and PaxDb:    About this image 
    TEF Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138870.1  NP_003207.1  

    ENSEMBL proteins: 
     ENSP00000385256   ENSP00000266304   ENSP00000411170   ENSP00000400221  

    Human Recombinant Protein Products for TEF: 
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    Novus Biologicals TEF Proteins
    Novus Biologicals TEF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TEF

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TEF for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TEF


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TEF for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q10587

    ProtoNet protein and cluster: Q10587

    UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587
    Similarity: Belongs to the bZIP family. PAR subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEF_HUMAN, Q10587
    Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding
    sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'
    Induction: Accumulates according to a robust circadian rhythm (By similarity)

         Genatlas biochemistry entry for TEF:
    thyrotroph embryonic factor,accumulating in liver and kidney,according to a robust circadian rythm

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TEF for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TEF:
     Decreased melanin production  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tef):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    TEF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TEF 

    miRNA
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    OriGene 3'-UTR Clone (see all 2): TEF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEF
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TEF (see all 33):
    hsa-miR-1197 hsa-miR-25 hsa-miR-4325 hsa-miR-92b hsa-miR-4257 hsa-miR-433 hsa-miR-4324 hsa-miR-595
    SwitchGear 3'UTR luciferase reporter plasmidTEF 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEF (see all 6)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEF

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/8 Interacting proteins for TEF (Q105873 ENSP000002663044) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBPQ105863, ENSP000002221224I2D: score=3 STRING: ENSP00000222122
    BATFQ165203I2D: score=1 
    BATF3Q9NR553I2D: score=1 
    CEBPGP535673I2D: score=1 
    DDIT3P356383I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7835883
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0048511rhythmic process IEA--

    TEF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TEF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEF
    1 Novoseek chemical compound relationship for TEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 51.5 2 1386162 (1)

    Search CenterWatch for drugs/clinical trials and news about TEF 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TEF gene (2 alternative transcripts): 
    NM_001145398.2  NM_003216.3  

    Unigene Cluster for TEF:

    Thyrotrophic embryonic factor
    Hs.181159  [show with all ESTs]
    Unigene Representative Sequence: NM_003216
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406644(uc003azx.3) ENST00000266304(uc021wqe.1 uc003azy.3 uc011apa.2)
    ENST00000413942 ENST00000433913

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEF
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TEF (see all 33):
    hsa-miR-1197 hsa-miR-25 hsa-miR-4325 hsa-miR-92b hsa-miR-4257 hsa-miR-433 hsa-miR-4324 hsa-miR-595
    SwitchGear 3'UTR luciferase reporter plasmidTEF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEF (see all 7)
    OriGene shRNA RFP: TEF
    OriGene siRNA: TEF
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TEF 
    Clone
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    Additional cDNA sequence: 

    AK295595.1 AK314906.1 AL122101.1 BC021980.2 BC039258.1 BC042476.2 BX537848.1 CR456592.1 
    CR541827.1 HM370396.1 U06935.1 U44059.1 

    2 DOTS entries:

    DT.95273592  DT.97781569 

    24/179 AceView cDNA sequences (see all 179):

    BF351880 AI656365 BU732572 CB853105 CD723293 BX537848 CB134388 AI808514 
    AW263707 BC021980 AA889997 CD172302 CB128001 AA318265 BF223523 AA983452 
    BG054516 BQ448238 BU176621 BQ649994 BU950269 CD519424 BQ017178 BM712249 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TEF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
    SP1:        -     -           -                       -                     
    SP2:        -                 -                                             
    SP3:              -           -                                             
    SP4:                                                  -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for TEF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGTGATA
    TEF Expression
    About this image
    See TEF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEF

    SOURCE GeneReport for Unigene cluster: Hs.181159
        SABiosciences Expression via Pathway-Focused PCR Array including TEF: 

              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TEF gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TEF1 thyrotrophic embryonic factor 77.78(n)
    85.77(a)
      396342  NM_205382.1  NP_990713.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEF6
    --
    76(a)
    1 ↔ 1
    5(26392150-26401913)
    African clawed frog
    (Xenopus laevis)
    Amphibia tef-prov2 thyrotrophic embryonic factor 79.22(n)    BC054981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tef2 thyrotroph embryonic factor 81.26(n)   30674  NM_131400.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdp16
    PAR-domain protein 1
    16(a)
    1 → many
    3L(7805015-7860469)


    ENSEMBL Gene Tree for TEF (if available)
    TreeFam Gene Tree for TEF (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEF gene
    DBP2  HLF2  
    2 SIMAP similar genes for TEF using alignment to 4 protein entries:     TEF_HUMAN (see all proteins):
    HLF    DBP

    TEF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/594 NCBI SNPs in TEF are shown (see all 594    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609923861,2
    C--24730866(+) CATCAC/TCAGGT 1 -- us2k12Minor allele frequency- T:0.11WA 120
    rs738857811,2
    C--24730887(+) GTCCCC/TGCAGG 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1126926061,2
    --24731631(+) GCTGGT/ACTGTG 1 -- spd12Minor allele frequency- A:0.17CSA WA 120
    rs60023551,2
    C,F,H--24732174(+) TGACTC/GTGGGT 1 -- int18Minor allele frequency- G:0.13NS EA NA WA 530
    rs126282251,2
    C,F,H--24732307(+) CTTTGG/CATGAC 1 -- int16Minor allele frequency- C:0.01NS EA 598
    rs1118488671,2
    --24732879(+) GGTGCC/AACGTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1885942421,2
    --41761348(+) CTCTGC/GTGGTC 1 -- us2k10--------
    rs1136206411,2
    C--41761383(+) ATGTTTGTG/-  
            
    TGTGT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2012088161,2
    C--41761383(+) AATGTG/TTGTGT 1 -- us2k10--------
    rs1395760991,2
    C--41761384(+) ATGTT-/TGTGTG
            
    TGTGT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEF (41763337 - 41795330 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TEF
         4 CNVs: 5188 50867 50866 5189

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TEF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TEF for disorders           About GeneDecksing

    OMIM gene information: 188595    OMIM disorders: --

    20/21 diseases for TEF (see all 21):    About MalaCards
    newborn respiratory distress syndrome    imperforate anus    congenital diaphragmatic hernia    hepatitis
    vacterl association    gastroesophageal reflux disease    thyroiditis    leukemia
    tracheal stenosis    megaesophagus    edwards syndrome    dextrocardia
    polyhydramnios    esophageal atresia    hernia    pneumothorax
    sleep disorder    pituitary adenoma    adenoma    esophagitis

    7 diseases from the University of Copenhagen DISEASES database for TEF:
    Esophageal atresia     Tracheal stenosis     Gastroesophageal reflux disease     VACTERL association
    Imperforate anus     Congenital diaphragmatic hernia     Pneumonia

    1 Novoseek disease relationship for TEF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 35.6 2 12609830 (1), 8639829 (1)

    Human Genome Epidemiology (HuGE) Navigator: TEF (3 documents)

    Export disorders for TEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEF gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PubMed id 7835883)1, 2, 3, 9 Khatib Z.A.... Look A.T. (1994)
    2. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PubMed id 8639829)1, 2, 9 Hunger S.P.... Cleary M.L. (1996)
    3. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. (PubMed id 15665112)1, 3 Inukai T....Nakazawa S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease. (PubMed id 22257907)1 Hua P....Xiao H. (2012)
    9. A novel pathway of TEF regulation mediated by microRNA -125b contributes to the control of actin distribution and cell shape in fibrobl asts. (PubMed id 21347262)1 Gutierrez O....Fernandez-Luna J.L. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7008 HGNC: 11722 AceView: TEF Ensembl:ENSG00000167074 euGenes: HUgn7008
    ECgene: TEF H-InvDB: TEF

    (According to HUGE)
    About This Section
    HUGE: KIAA1655

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TEF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TEF gene:
    Search GeneIP for patents involving TEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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