External Ids for TEF Gene
Previous GeneCards Identifiers for TEF Gene
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for TEF Gene
TEF (Thyrotrophic Embryonic Factor) is a Protein Coding gene. Diseases associated with TEF include tracheal stenosis and imperforate anus. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DBP.
UniProtKB/Swiss-Prot for TEF Gene
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5-[TC][AG][AG]TTA[TC][AG]-3