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Aliases for TEF Gene

Aliases for TEF Gene

  • TEF, PAR BZIP Transcription Factor 2 3
  • Thyrotrophic Embryonic Factor 2 5
  • KIAA1655 4

External Ids for TEF Gene

Previous GeneCards Identifiers for TEF Gene

  • GC22P038392
  • GC22P040006
  • GC22P040021
  • GC22P040102
  • GC22P041763
  • GC22P024729

Summaries for TEF Gene

Entrez Gene Summary for TEF Gene

  • This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for TEF Gene

TEF (TEF, PAR BZIP Transcription Factor) is a Protein Coding gene. Diseases associated with TEF include Trachea Leiomyoma and Esophageal Disease. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DBP.

UniProtKB/Swiss-Prot for TEF Gene

  • Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5-[TC][AG][AG]TTA[TC][AG]-3.

Gene Wiki entry for TEF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEF Gene

Genomics for TEF Gene

Regulatory Elements for TEF Gene

Enhancers for TEF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TEF on UCSC Golden Path with GeneCards custom track

Promoters for TEF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TEF on UCSC Golden Path with GeneCards custom track

Genomic Location for TEF Gene

41,367,333 bp from pter
41,399,328 bp from pter
31,996 bases
Plus strand

Genomic View for TEF Gene

Genes around TEF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEF Gene

Proteins for TEF Gene

  • Protein details for TEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyrotroph embryonic factor
    Protein Accession:
    Secondary Accessions:
    • B0QYS8
    • B2RC22
    • Q15729
    • Q7Z3J7
    • Q8IU94
    • Q96TG4

    Protein attributes for TEF Gene

    303 amino acids
    Molecular mass:
    33248 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.
    • Sequence=AAA81373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEF Gene


neXtProt entry for TEF Gene

Proteomics data for TEF Gene at MOPED

Post-translational modifications for TEF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEF Gene

No data available for DME Specific Peptides for TEF Gene

Domains & Families for TEF Gene

Gene Families for TEF Gene

Protein Domains for TEF Gene


Suggested Antigen Peptide Sequences for TEF Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with TEF: view

Function for TEF Gene

Molecular function for TEF Gene

GENATLAS Biochemistry:
thyrotroph embryonic factor,accumulating in liver and kidney,according to a robust circadian rythm
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5-[TC][AG][AG]TTA[TC][AG]-3.
UniProtKB/Swiss-Prot Induction:
Accumulates according to a robust circadian rhythm.

Gene Ontology (GO) - Molecular Function for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEF: view
genes like me logo Genes that share phenotypes with TEF: view

Animal Models for TEF Gene

MGI Knock Outs for TEF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEF Gene

Localization for TEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEF Gene


Subcellular locations from

Jensen Localization Image for TEF Gene COMPARTMENTS Subcellular localization image for TEF gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TEF Gene

Pathways & Interactions for TEF Gene

SuperPathways for TEF Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TEF: view

No data available for Pathways by source and SIGNOR curated interactions for TEF Gene

Drugs & Compounds for TEF Gene

(1) Drugs for TEF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TEF: view

Transcripts for TEF Gene

Unigene Clusters for TEF Gene

Thyrotrophic embryonic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for TEF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEF Gene

mRNA expression in normal human tissues for TEF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TEF Gene

This gene is overexpressed in Heart (62.0) and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEF Gene

SOURCE GeneReport for Unigene cluster for TEF Gene Hs.181159

genes like me logo Genes that share expression patterns with TEF: view

Protein tissue co-expression partners for TEF Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TEF Gene

Orthologs for TEF Gene

This gene was present in the common ancestor of animals.

Orthologs for TEF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TEF 35
  • 92.72 (n)
  • 97.68 (a)
TEF 36
  • 95 (a)
(Canis familiaris)
Mammalia TEF 35
  • 92.3 (n)
  • 97.36 (a)
TEF 36
  • 95 (a)
(Mus musculus)
Mammalia Tef 35
  • 91.14 (n)
  • 96.68 (a)
Tef 16
Tef 36
  • 98 (a)
(Pan troglodytes)
Mammalia TEF 35
  • 99.89 (n)
  • 100 (a)
TEF 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tef 35
  • 90.7 (n)
  • 97.01 (a)
(Monodelphis domestica)
Mammalia TEF 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TEF 36
  • 92 (a)
(Gallus gallus)
Aves TEF 35
  • 76.58 (n)
  • 83.27 (a)
TEF 36
  • 76 (a)
(Anolis carolinensis)
Reptilia TEF 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tef 35
  • 66.42 (n)
  • 67.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia tef-prov 35
(Danio rerio)
Actinopterygii tef 35
tefb 35
  • 63.45 (n)
  • 62.61 (a)
tefa 36
  • 55 (a)
tefb 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 36
  • 10 (a)
Species with no ortholog for TEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEF Gene

Gene Tree for TEF (if available)
Gene Tree for TEF (if available)

Paralogs for TEF Gene

Paralogs for TEF Gene

(2) SIMAP similar genes for TEF Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEF: view

Variants for TEF Gene

Sequence variations from dbSNP and Humsavar for TEF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2234060 -- 41,393,496(+) tcatg(C/T)ctgta intron-variant
rs2234061 -- 41,394,309(+) CGACG(C/T)GCAGA reference, missense
rs2234062 -- 41,395,986(+) GGGGT(A/G)CTGCC utr-variant-3-prime
rs2273071 -- 41,394,496(+) AGTCA(C/T)GTGGC intron-variant
rs34086189 -- 41,392,041(+) CCAGG(-/GA)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEF Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990
nsv516925 CNV Loss 19592680
nsv834207 CNV Loss 17160897
nsv915154 CNV Loss 21882294
nsv834208 CNV Loss 17160897

Variation tolerance for TEF Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TEF Gene

Disorders for TEF Gene

MalaCards: The human disease database

(4) MalaCards diseases for TEF Gene - From: DISEASES

Disorder Aliases PubMed IDs
trachea leiomyoma
  • tracheal neoplasm
esophageal disease
  • esophageal ulcer
diaphragm disease
  • disease of diaphragm
diaphragmatic eventration
- elite association - COSMIC cancer census association via MalaCards
Search TEF in MalaCards View complete list of genes associated with diseases

Relevant External Links for TEF

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TEF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEF Gene

Publications for TEF Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib Z.A. … Look A.T. (Genomics 1994) 2 3 4 23 67
  2. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. (PMID: 15665112) Inukai T. … Nakazawa S. (Blood 2005) 2 3
  3. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PMID: 8639829) Hunger S.P. … Cleary M.L. (Blood 1996) 3 23
  4. Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. (PMID: 24581835) Hua P. … Kuo S.H. (J Affect Disord 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TEF Gene

Sources for TEF Gene