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Aliases for TEF Gene

Aliases for TEF Gene

  • Thyrotrophic Embryonic Factor 2 3
  • KIAA1655 4

External Ids for TEF Gene

Previous GeneCards Identifiers for TEF Gene

  • GC22P038392
  • GC22P040006
  • GC22P040021
  • GC22P040102
  • GC22P041763
  • GC22P024729

Summaries for TEF Gene

Entrez Gene Summary for TEF Gene

  • This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for TEF Gene

TEF (Thyrotrophic Embryonic Factor) is a Protein Coding gene. Diseases associated with TEF include tracheal stenosis and imperforate anus. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DBP.

UniProtKB/Swiss-Prot for TEF Gene

  • Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5-[TC][AG][AG]TTA[TC][AG]-3

Gene Wiki entry for TEF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEF Gene

Genomics for TEF Gene

Regulatory Elements for TEF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TEF Gene

Start:
41,367,333 bp from pter
End:
41,399,328 bp from pter
Size:
31,996 bases
Orientation:
Plus strand

Genomic View for TEF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEF Gene

Proteins for TEF Gene

  • Protein details for TEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10587-TEF_HUMAN
    Recommended name:
    Thyrotroph embryonic factor
    Protein Accession:
    Q10587
    Secondary Accessions:
    • B0QYS8
    • B2RC22
    • Q15729
    • Q7Z3J7
    • Q8IU94
    • Q96TG4

    Protein attributes for TEF Gene

    Size:
    303 amino acids
    Molecular mass:
    33248 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP
    SequenceCaution:
    • Sequence=AAA81373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEF Gene

Proteomics data for TEF Gene at MOPED

Post-translational modifications for TEF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEF Gene

No data available for DME Specific Peptides for TEF Gene

Domains for TEF Gene

Gene Families for TEF Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for TEF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEF Gene

Graphical View of Domain Structure for InterPro Entry

Q10587

UniProtKB/Swiss-Prot:

TEF_HUMAN :
  • Q10587
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with TEF: view

Function for TEF Gene

Molecular function for TEF Gene

GENATLAS Biochemistry: thyrotroph embryonic factor,accumulating in liver and kidney,according to a robust circadian rythm
UniProtKB/Swiss-Prot Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5-[TC][AG][AG]TTA[TC][AG]-3
UniProtKB/Swiss-Prot Induction: Accumulates according to a robust circadian rhythm.

Gene Ontology (GO) - Molecular Function for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TEF: view
genes like me logo Genes that share phenotypes with TEF: view

Animal Model Products

CRISPR Products

miRNA for TEF Gene

miRTarBase miRNAs that target TEF

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TEF Gene

Localization for TEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEF Gene COMPARTMENTS Subcellular localization image for TEF gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TEF: view

Pathways for TEF Gene

SuperPathways for TEF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7835883
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with TEF: view

No data available for Pathways by source for TEF Gene

Compounds for TEF Gene

(1) Novoseek inferred chemical compound relationships for TEF Gene

Compound -log(P) Hits PubMed IDs
leucine 51.5 1
genes like me logo Genes that share compounds with TEF: view

Transcripts for TEF Gene

Unigene Clusters for TEF Gene

Thyrotrophic embryonic factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEF

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TEF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for TEF Gene

GeneLoc Exon Structure for
TEF
ECgene alternative splicing isoforms for
TEF

Expression for TEF Gene

mRNA expression in normal human tissues for TEF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TEF Gene

SOURCE GeneReport for Unigene cluster for TEF Gene Hs.181159

genes like me logo Genes that share expressions with TEF: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TEF Gene

Orthologs for TEF Gene

This gene was present in the common ancestor of animals.

Orthologs for TEF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEF 35
  • 99.89 (n)
  • 100 (a)
TEF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEF 35
  • 92.72 (n)
  • 97.68 (a)
TEF 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEF 35
  • 92.3 (n)
  • 97.36 (a)
TEF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tef 35
  • 91.14 (n)
  • 96.68 (a)
Tef 16
Tef 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEF 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEF 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tef 35
  • 90.7 (n)
  • 97.01 (a)
chicken
(Gallus gallus)
Aves TEF 35
  • 76.58 (n)
  • 83.27 (a)
TEF 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEF 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tef-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tef 35
  • 66.42 (n)
  • 67.54 (a)
zebrafish
(Danio rerio)
Actinopterygii tef 35
tefa 36
  • 55 (a)
OneToMany
tefb 35
  • 63.45 (n)
  • 62.61 (a)
tefb 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 36
  • 10 (a)
OneToMany
Species with no ortholog for TEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEF Gene

ENSEMBL:
Gene Tree for TEF (if available)
TreeFam:
Gene Tree for TEF (if available)

Paralogs for TEF Gene

Paralogs for TEF Gene

Selected SIMAP similar genes for TEF Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEF: view

Variants for TEF Gene

Sequence variations from dbSNP and Humsavar for TEF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738499 -- 41,381,096(+) GTGTT(G/T)ATCTG intron-variant, upstream-variant-2KB
rs767593 -- 41,383,967(+) TCTCA(G/T)TTGGT intron-variant
rs2073167 -- 41,395,532(+) CACCA(C/T)GTAAC intron-variant
rs2234052 -- 41,381,237(+) GGCTA(A/G)GCTCA intron-variant, upstream-variant-2KB
rs2234053 -- 41,381,311(+) CTCCC(G/T)CCCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEF Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990
nsv516925 CNV Loss 19592680
nsv834207 CNV Loss 17160897
nsv915154 CNV Loss 21882294
nsv834208 CNV Loss 17160897

Relevant External Links for TEF Gene

HapMap Linkage Disequilibrium report
TEF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEF Gene

Disorders for TEF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TEF Gene including...

Search for TEF Gene in MalaCards »

(1) Novoseek inferred disease relationships for TEF Gene

Disease -log(P) Hits PubMed IDs
leukemia 35.6 2

Relevant External Links for TEF

Human Genome Epidemiology (HuGE) Navigator
TEF
genes like me logo Genes that share disorders with TEF: view

No data available for UniProtKB/Swiss-Prot for TEF Gene

Publications for TEF Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib Z.A. … Look A.T. (Genomics 1994) 2 3 4 23
  2. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PMID: 8639829) Hunger S.P. … Cleary M.L. (Blood 1996) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TEF Gene

Sources for TEF Gene

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