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TEF Gene

protein-coding   GIFtS: 55
GCID: GC22P041763

Thyrotrophic Embryonic Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyrotrophic Embryonic Factor1 2
Thyrotroph Embryonic Factor2
KIAA16553

External Ids:    HGNC: 117221   Entrez Gene: 70082   Ensembl: ENSG000001670747   OMIM: 1885955   UniProtKB: Q105873   

Export aliases for TEF gene to outside databases

Previous GC identifers: GC22P038392 GC22P040006 GC22P040021 GC22P040102 GC22P024729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEF Gene:
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine
zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals,
however, during embryonic development, TEF expression appears to be restricted to the developing anterior
pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind
to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the
PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic
leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken
homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and
transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for TEF Gene:
TEF (thyrotrophic embryonic factor) is a protein-coding gene. Diseases associated with TEF include megaesophagus, and newborn respiratory distress syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DBP.

UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587
Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding
sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'

Gene Wiki entry for TEF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEF gene promoter:
         CREB   AhR   p53   AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TEF promoter sequence
   Search Chromatin IP Primers for TEF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

TEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P041763:  view genomic region     (about GC identifiers)

Start:
41,763,337 bp from pter      End:
41,795,330 bp from pter
Size:
31,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587 (See protein sequence)
Recommended Name: Thyrotroph embryonic factor  
Size: 303 amino acids; 33248 Da
Subunit: Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP
Sequence caution: Sequence=AAA81373.1; Type=Erroneous initiation;
Secondary accessions: B0QYS8 B2RC22 Q15729 Q7Z3J7 Q8IU94 Q96TG4
Alternative splicing: 2 isoforms:  Q10587-1   Q10587-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEF: NX_Q10587

Explore proteomics data for TEF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TEF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138870.1  NP_003207.1  

    ENSEMBL proteins: 
     ENSP00000385256   ENSP00000266304   ENSP00000411170  

    TEF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TEF
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for TEF
    Novus Biologicals TEF Proteins
    Novus Biologicals TEF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TEF
    Cloud-Clone Corp. Proteins for TEF

    TEF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for TEF at Abcam
    Cloud-Clone Corp. Antibodies for TEF
    Search ThermoFisher Antibodies for TEF
    LSBio Antibodies in human, mouse, rat for TEF

    TEF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TEF
    Cloud-Clone Corp. CLIAs for TEF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q10587

    ProtoNet protein and cluster: Q10587

    UniProtKB/Swiss-Prot: TEF_HUMAN, Q10587
    Similarity: Belongs to the bZIP family. PAR subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    TEF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEF_HUMAN, Q10587
    Function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding
    sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'
    Induction: Accumulates according to a robust circadian rhythm (By similarity)

         Genatlas biochemistry entry for TEF:
    thyrotroph embryonic factor,accumulating in liver and kidney,according to a robust circadian rythm

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TEF for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TEF:
     Decreased melanin production  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tef):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    TEF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEF

    miRNA
    Products:
        
    miRTarBase miRNAs that target TEF:
    hsa-mir-186-5p (MIRT021130), hsa-mir-125b-5p (MIRT046057)

    Block miRNA regulation of human, mouse, rat TEF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEF (see all 33):
    hsa-miR-1197 hsa-miR-25 hsa-miR-4325 hsa-miR-92b hsa-miR-4257 hsa-miR-433 hsa-miR-4324 hsa-miR-595
    SwitchGear 3'UTR luciferase reporter plasmidTEF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TEF
    Predesigned siRNA for gene silencing in human, mouse, rat TEF

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TEF (NM_003216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEF

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TEF
    Browse ESI BIO Cell Lines and PureStem Progenitors for TEF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEF_HUMAN, Q10587: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    chloroplast1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TEF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TEF: 
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TEF

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for TEF (Q105873 ENSP000002663044) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBPQ105863, ENSP000002221224I2D: score=3 STRING: ENSP00000222122
    HES6Q96HZ43, ENSP000002729374I2D: score=1 STRING: ENSP00000272937
    BATFQ165203I2D: score=1 
    BATF3Q9NR553I2D: score=1 
    CEBPGP535673I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7835883
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0048511rhythmic process IEA--

    TEF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEF

    1 Novoseek inferred chemical compound relationship for TEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 51.5 2 1386162 (1)



    TEF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEF gene (2 alternative transcripts): 
    NM_001145398.2  NM_003216.3  

    Unigene Cluster for TEF:

    Thyrotrophic embryonic factor
    Hs.181159  [show with all ESTs]
    Unigene Representative Sequence: NM_003216
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406644(uc003azx.3) ENST00000266304(uc021wqe.1 uc003azy.3 uc011apa.2)
    ENST00000413942
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TEF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEF (see all 33):
    hsa-miR-1197 hsa-miR-25 hsa-miR-4325 hsa-miR-92b hsa-miR-4257 hsa-miR-433 hsa-miR-4324 hsa-miR-595
    SwitchGear 3'UTR luciferase reporter plasmidTEF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TEF
    Predesigned siRNA for gene silencing in human, mouse, rat TEF
    Clone
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    OriGene clones in human, mouse for TEF (see all 11)
    OriGene ORF clones in mouse, rat for TEF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TEF (NM_003216)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEF
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TEF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEF
      QuantiTect SYBR Green Assays in human, mouse, rat TEF
      QuantiFast Probe-based Assays in human, mouse, rat TEF

    Additional mRNA sequence: 

    AK295595.1 AK314906.1 AL122101.1 BC021980.2 BC039258.1 BC042476.2 BX537848.1 CR456592.1 
    CR541827.1 HM370396.1 U06935.1 U44059.1 

    2 DOTS entries:

    DT.95273592  DT.97781569 

    Selected AceView cDNA sequences (see all 179):

    BU161067 BU732572 CD369566 AA889997 CB158120 CB155521 AA318265 CD723293 
    CB853105 AI656365 CD172302 BG819891 BX537848 BC042476 AA757332 AW050863 
    BQ448238 CD519424 AI808514 BE019540 BU950269 BG054516 AW263707 BU176621 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TEF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
    SP1:        -     -           -                       -                     
    SP2:        -                 -                                             
    SP3:              -           -                                             
    SP4:                                                  -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for TEF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTGATA
    TEF Expression
    About this image


    TEF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Cardiac progenitor cells
    TEF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181159
        Pathway & Disease-focused RT2 Profiler PCR Array including TEF: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TEF
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    QuantiFast Probe-based Assays in human, mouse, rat TEF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tef1 , 5 thyrotroph embryonic factor1, 5 91.14(n)1
    96.68(a)1
      15 (38.25 cM)5
    216851  NM_017376.31  NP_059072.11 
     818024215 
    chicken
    (Gallus gallus)
    Aves TEF1 thyrotrophic embryonic factor 76.58(n)
    83.27(a)
      396342  NM_205382.1  NP_990713.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEF6
    thyrotrophic embryonic factor
    78(a)
    1 ↔ 1
    5(26391587-26401913)
    African clawed frog
    (Xenopus laevis)
    Amphibia tef-prov2 thyrotrophic embryonic factor 79.22(n)    BC054981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tef2 thyrotroph embryonic factor 81.26(n)   30674  NM_131400.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdp16
    PAR-domain protein 1
    16(a)
    1 → many
    3L(7805015-7860469)


    ENSEMBL Gene Tree for TEF (if available)
    TreeFam Gene Tree for TEF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEF gene
    DBP2  HLF2  
    2 SIMAP similar genes for TEF using alignment to 4 protein entries:     TEF_HUMAN (see all proteins):
    HLF    DBP

    TEF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEF (see all 662)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48204371,2
    C,F,A,H--24727795(+) CAGGGC/TTCTGG 1 -- us2k120Minor allele frequency- T:0.42NS EA NA WA CSA 2342
    rs1840005941,2
    --24727821(+) AGGGGG/TTCTCT 1 -- us2k10--------
    rs1885942421,2
    --41761348(+) CTCTGC/GTGGTC 1 -- us2k10--------
    rs1136206411,2
    C--41761383(+) ATGTTTGTG/-  
            
    TGTGT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2012088161,2
    C--41761383(+) AATGTG/TTGTGT 1 -- us2k10--------
    rs676172871,2
    C--41761384(+) TGTTT-/TGTG  
     
    /TGTGTG
    GTGTG
    2 -- us2k1 cds10--------
    rs1395760991,2
    C--41761384(+) ATGTT-/TGTGTG
            
    TGTGT
    1 -- us2k10--------
    rs105221821,2
    C--41761386(+) TGTGT-/GTGT  
     
    /GTGTGT
    CATAA
    2 -- us2k1 cds10--------
    rs666231241,2
    C--41761397(+) TGTGT-/GT/   
      GTGTGT
    CATAA
    1 -- us2k12NA 4
    rs1928334391,2
    --41761504(+) TTCCTC/TGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEF (41763337 - 41795330 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TEF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834208CNV Loss17160897
    nsv915154CNV Loss21882294
    nsv516925CNV Loss19592680
    nsv834207CNV Loss17160897
    nsv915119CNV Loss21882294
    nsv524585CNV Loss19592680
    nsv459888CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEF
    DNA2.0 Custom Variant and Variant Library Synthesis for TEF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188595    OMIM disorders: --

    Selected diseases for TEF (see all 21):    
    About MalaCards
    megaesophagus    newborn respiratory distress syndrome    edwards syndrome    vacterl association
    tracheal stenosis    dextrocardia    imperforate anus    sleep disorder
    esophageal atresia    polyhydramnios    pneumothorax    congenital diaphragmatic hernia
    gastroesophageal reflux disease    hepatitis    thyroiditis    pituitary adenoma
    leukemia    parkinson's disease    adenoma    pneumonia

    7 diseases from the University of Copenhagen DISEASES database for TEF:
    Esophageal atresia     Tracheal stenosis     Gastroesophageal reflux disease     VACTERL association
    Imperforate anus     Congenital diaphragmatic hernia     Pneumonia

    TEF for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TEF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 35.6 2 12609830 (1), 8639829 (1)

    Human Genome Epidemiology (HuGE) Navigator: TEF (3 documents)

    Export disorders for TEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEF gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PubMed id 7835883)1, 2, 3, 9 Khatib Z.A.... Look A.T. (Genomics 1994)
    2. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PubMed id 8639829)1, 2, 9 Hunger S.P.... Cleary M.L. (Blood 1996)
    3. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. (PubMed id 15665112)1, 3 Inukai T....Nakazawa S. (Blood 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    8. Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease. (PubMed id 22257907)1 Hua P....Xiao H. (Sleep Med. 2012)
    9. Association of Tef polymorphism with depression in Parkinson disease. (PubMed id 23138696)1 Hua P....Wu T. (Mov. Disord. 2012)
    10. A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts. (PubMed id 21347262)1 Gutierrez O....Fernandez-Luna J.L. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7008 HGNC: 11722 AceView: TEF Ensembl:ENSG00000167074 euGenes: HUgn7008
    ECgene: TEF H-InvDB: TEF

    (According to HUGE)
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    HUGE: KIAA1655

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TEF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEF gene:
    Search GeneIP for patents involving TEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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