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Aliases for TEDC2 Gene

Aliases for TEDC2 Gene

  • Tubulin Epsilon And Delta Complex 2 2 3
  • C16orf59 3 4 5
  • Chromosome 16 Open Reading Frame 59 2 5
  • Uncharacterized Protein C16orf59 3

External Ids for TEDC2 Gene

Previous HGNC Symbols for TEDC2 Gene

  • C16orf59

Summaries for TEDC2 Gene

GeneCards Summary for TEDC2 Gene

TEDC2 (Tubulin Epsilon And Delta Complex 2) is a Protein Coding gene.

Additional gene information for TEDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEDC2 Gene

Genomics for TEDC2 Gene

Regulatory Elements for TEDC2 Gene

Enhancers for TEDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002467 1.6 FANTOM5 ENCODE dbSUPER 3.8 +9.6 9615 5.4 HDGF ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF143 ZNF207 ZNF75A TSC2 ZNF213-AS1 ERVK13-1 ENSG00000226890 ENSG00000200059 CRAMP1 ENSG00000261240 ZNF263 TELO2
GH16H002459 1 ENCODE 0.7 +0.1 74 1.5 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 TELO2 ZNF263 SRRM2 SNORA64 CCNF ENSG00000260954 ENSG00000255513 LOC105371055 CRAMP1 ABCA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEDC2 on UCSC Golden Path with GeneCards custom track

Promoters for TEDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082477 120 801 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A ZNF2 GLIS2 ZNF143 ZNF548

Genomic Locations for TEDC2 Gene

Genomic Locations for TEDC2 Gene
chr16:2,460,080-2,464,963
(GRCh38/hg38)
Size:
4,884 bases
Orientation:
Plus strand
chr16:2,510,081-2,514,964
(GRCh37/hg19)

Genomic View for TEDC2 Gene

Genes around TEDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEDC2 Gene

Proteins for TEDC2 Gene

  • Protein details for TEDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2K0-CP059_HUMAN
    Recommended name:
    Uncharacterized protein C16orf59
    Protein Accession:
    Q7L2K0
    Secondary Accessions:
    • B4DXD7
    • Q96H61
    • Q9H872

    Protein attributes for TEDC2 Gene

    Size:
    433 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TEDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEDC2 Gene

Post-translational modifications for TEDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEDC2 Gene

Domains & Families for TEDC2 Gene

Gene Families for TEDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEDC2: view

No data available for UniProtKB/Swiss-Prot for TEDC2 Gene

Function for TEDC2 Gene

Gene Ontology (GO) - Molecular Function for TEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEDC2: view
genes like me logo Genes that share phenotypes with TEDC2: view

miRNA for TEDC2 Gene

miRTarBase miRNAs that target TEDC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEDC2 Gene

Localization for TEDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEDC2 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TEDC2 Gene

Pathways & Interactions for TEDC2 Gene

SuperPathways for TEDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEDC2 Gene

Drugs & Compounds for TEDC2 Gene

No Compound Related Data Available

Transcripts for TEDC2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEDC2 Gene

No ASD Table

Relevant External Links for TEDC2 Gene

GeneLoc Exon Structure for
TEDC2
ECgene alternative splicing isoforms for
TEDC2

Expression for TEDC2 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEDC2 Gene

Orthologs for TEDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf59 33
  • 98.69 (n)
C16orf59 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C25H16orf59 33
  • 79.76 (n)
C16orf59 34
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H16orf59 33
  • 78.38 (n)
C16orf59 34
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100158225 33
  • 73.11 (n)
mouse
(Mus musculus)
Mammalia 1600002H07Rik 33 34
  • 72.69 (n)
Tedc2 16
oppossum
(Monodelphis domestica)
Mammalia C16orf59 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16orf59 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C16orf59 34
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485766 33
  • 44.74 (n)
Species where no ortholog for TEDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEDC2 Gene

ENSEMBL:
Gene Tree for TEDC2 (if available)
TreeFam:
Gene Tree for TEDC2 (if available)

Paralogs for TEDC2 Gene

No data available for Paralogs for TEDC2 Gene

Variants for TEDC2 Gene

Sequence variations from dbSNP and Humsavar for TEDC2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000288682 -- 2,465,120(+) CACCA(C/T)GCCTG nc-transcript-variant, downstream-variant-500B
rs1000319816 -- 2,460,643(+) CCGGG(C/G)TTTGA upstream-variant-2KB, reference, missense
rs1000430269 -- 2,464,931(+) GAGCC(A/G)CTTGT downstream-variant-500B, utr-variant-3-prime
rs1000681638 -- 2,460,115(+) GAGGC(A/G)GCAAA upstream-variant-2KB, utr-variant-5-prime
rs1001729051 -- 2,461,507(+) AGGGC(A/G)TGGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TEDC2 Gene

Variant ID Type Subtype PubMed ID
nsv952903 CNV deletion 24416366
nsv833121 CNV loss 17160897
nsv827513 CNV gain 20364138
nsv571205 CNV gain 21841781
nsv1052260 CNV gain 25217958
esv2422427 CNV duplication 17116639
dgv4864n54 CNV loss 21841781

Variation tolerance for TEDC2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEDC2 Gene

Disorders for TEDC2 Gene

Relevant External Links for TEDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEDC2

No disorders were found for TEDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEDC2 Gene

Publications for TEDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TEDC2 Gene

Sources for TEDC2 Gene

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